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6 results on '"Gulisano, Walter"'

1. Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer’s disease

Author

Natale, Francesca, Spinelli, Matteo, Rinaudo, Marco, Gulisano, Walter, Nifo Sarrapochiello, Ida, Aceto, Giuseppe, Puzzo, Daniela, Fusco, Salvatore, Grassi, Claudio, Natale, Francesca (ORCID:0000-0001-7856-930X), Rinaudo, Marco (ORCID:0000-0002-6130-7335), Aceto, Giuseppe (ORCID:0000-0002-7530-6835), Fusco, Salvatore (ORCID:0000-0003-3294-0016), Grassi, Claudio (ORCID:0000-0001-7253-1685), Natale, Francesca, Spinelli, Matteo, Rinaudo, Marco, Gulisano, Walter, Nifo Sarrapochiello, Ida, Aceto, Giuseppe, Puzzo, Daniela, Fusco, Salvatore, Grassi, Claudio, Natale, Francesca (ORCID:0000-0001-7856-930X), Rinaudo, Marco (ORCID:0000-0002-6130-7335), Aceto, Giuseppe (ORCID:0000-0002-7530-6835), Fusco, Salvatore (ORCID:0000-0003-3294-0016), and Grassi, Claudio (ORCID:0000-0001-7253-1685)

Published
2024

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Author

Puzzo, Daniela, Piacentini, Roberto, Fá, Mauro, Gulisano, Walter, Li Puma, Domenica Donatella, Staniszewski, Agne, Zhang, Hong, Tropea, Maria Rosaria, Cocco, Sara, Palmeri, Agostino, Fraser, Paul, D'Adamio, Luciano, Grassi, Claudio, Arancio, Ottavio, Piacentini, Roberto (ORCID:0000-0003-4215-1643), Li Puma, Domenica Donatella (ORCID:0000-0001-6729-6967), Grassi, Claudio (ORCID:0000-0001-7253-1685), Puzzo, Daniela, Piacentini, Roberto, Fá, Mauro, Gulisano, Walter, Li Puma, Domenica Donatella, Staniszewski, Agne, Zhang, Hong, Tropea, Maria Rosaria, Cocco, Sara, Palmeri, Agostino, Fraser, Paul, D'Adamio, Luciano, Grassi, Claudio, Arancio, Ottavio, Piacentini, Roberto (ORCID:0000-0003-4215-1643), Li Puma, Domenica Donatella (ORCID:0000-0001-6729-6967), and Grassi, Claudio (ORCID:0000-0001-7253-1685)

Published
2017

3. Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Author

Prickaerts, Jos, Prickaerts, Jos, Van Goethem, Nick P., Gulisano, Walter, Argyrousi, Elentina K., Palmeri, Agostino, Puzzo, Daniela, Prickaerts, Jos, Prickaerts, Jos, Van Goethem, Nick P., Gulisano, Walter, Argyrousi, Elentina K., Palmeri, Agostino, and Puzzo, Daniela

Abstract

The response of a biological system to an endogenous or exogenous molecule depends upon the dose. For this reason, performing dose-response curves is crucial to understand physiological and pathophysiological phenomena, and to predict the effect of a drug. Most of the studies in pharmacological research have been performed according to the classical threshold model, focusing on higher doses able to ensure a biological effect. However, recent evidences pointed out the need to investigate the effect of low doses. Indeed, several molecules behave in a hormetic fashion, i.e. low-doses stimulate whereas high-doses inhibit a biological response. This is particularly interesting in CNS, where several physiological molecules involved in neuronal transmission during learning and memory have shown a biphasic effect that might represent the link between physiology and pathology.In this review we will focus on cholinergic, glutamatergic and nitrinergic transmission, because of their central role in learning and memory and their impairment in neurodegenerative disorders such as Alzheimer's disease.Pre-clinical studies performed on healthy adult animals and aged animals, as well as transgenic animal models of AD, have suggested a biphasic DR for acetylcholine, glutamate and nitric oxide. This stresses the relevance to perform DR curves when studying the mechanisms underlying synaptic plasticity and memory, the pharmacological profile of cognitive-enhancing drugs acting on these systems, and the possibility to combine low/ineffective doses of drugs that might have additive/synergistic effects, reducing the unwanted side effects associated to the high doses.

Published
2017

4. Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Author

Prickaerts, Jos, Van Goethem, Nick P., Gulisano, Walter, Argyrousi, Elentina K., Palmeri, Agostino, Puzzo, Daniela, Prickaerts, Jos, Van Goethem, Nick P., Gulisano, Walter, Argyrousi, Elentina K., Palmeri, Agostino, and Puzzo, Daniela

Abstract

The response of a biological system to an endogenous or exogenous molecule depends upon the dose. For this reason, performing dose-response curves is crucial to understand physiological and pathophysiological phenomena, and to predict the effect of a drug. Most of the studies in pharmacological research have been performed according to the classical threshold model, focusing on higher doses able to ensure a biological effect. However, recent evidences pointed out the need to investigate the effect of low doses. Indeed, several molecules behave in a hormetic fashion, i.e. low-doses stimulate whereas high-doses inhibit a biological response. This is particularly interesting in CNS, where several physiological molecules involved in neuronal transmission during learning and memory have shown a biphasic effect that might represent the link between physiology and pathology.In this review we will focus on cholinergic, glutamatergic and nitrinergic transmission, because of their central role in learning and memory and their impairment in neurodegenerative disorders such as Alzheimer's disease.Pre-clinical studies performed on healthy adult animals and aged animals, as well as transgenic animal models of AD, have suggested a biphasic DR for acetylcholine, glutamate and nitric oxide. This stresses the relevance to perform DR curves when studying the mechanisms underlying synaptic plasticity and memory, the pharmacological profile of cognitive-enhancing drugs acting on these systems, and the possibility to combine low/ineffective doses of drugs that might have additive/synergistic effects, reducing the unwanted side effects associated to the high doses.

Published
2017

5. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

Author

Fa', Mauro, Puzzo, Daniela, Piacentini, Roberto, Staniszewski, Agnieszka, Zhang, Hong, Baltrons, Maria Antonia, Li Puma, Domenica Donatella, Chatterjee, Ishita, Li, Jin, Saeed, Faisal, Berman, Hanna, Ripoli, Cristian, Gulisano, Walter, Gonzalez, Juana, Tian, Huilai, Costa, Jonathon, Lopez, Patricia, Davidowitz, Eliot, Yu, Wai Haung, Haroutunian, Vahram, Brown, Lewi, Palmeri, Agostino, Sigurdsson, Einar, Duff, Karen, Teich, Andrew Franklin, Honig, Lawrence, Sierks, Michael, Moe, Jame, D’Adamio, Luciano, Grassi, Claudio, Kanaan, Nichola, Fraser, Paul, Arancio, Ottavio, Piacentini, Roberto (ORCID:0000-0003-4215-1643), Li Puma, Domenica Donatella (ORCID:0000-0001-6729-6967), Ripoli, Cristian (ORCID:0000-0002-5315-0163), Grassi, Claudio (ORCID:0000-0001-7253-1685), Fa', Mauro, Puzzo, Daniela, Piacentini, Roberto, Staniszewski, Agnieszka, Zhang, Hong, Baltrons, Maria Antonia, Li Puma, Domenica Donatella, Chatterjee, Ishita, Li, Jin, Saeed, Faisal, Berman, Hanna, Ripoli, Cristian, Gulisano, Walter, Gonzalez, Juana, Tian, Huilai, Costa, Jonathon, Lopez, Patricia, Davidowitz, Eliot, Yu, Wai Haung, Haroutunian, Vahram, Brown, Lewi, Palmeri, Agostino, Sigurdsson, Einar, Duff, Karen, Teich, Andrew Franklin, Honig, Lawrence, Sierks, Michael, Moe, Jame, D’Adamio, Luciano, Grassi, Claudio, Kanaan, Nichola, Fraser, Paul, Arancio, Ottavio, Piacentini, Roberto (ORCID:0000-0003-4215-1643), Li Puma, Domenica Donatella (ORCID:0000-0001-6729-6967), Ripoli, Cristian (ORCID:0000-0002-5315-0163), and Grassi, Claudio (ORCID:0000-0001-7253-1685)

Published
2016

6. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

Author

FA', MAURO, PUZZO, DANIELA, PIACENTINI, ROBERTO, STANISZEWSKI, AGNIESZKA, ZHANG, HONG, BALTRONS, MARIA ANTONIA, LI PUMA, DOMENICA DONATELLA, CHATTERJEE, ISHITA, LI, JIN, SAEED, FAISAL, BERMAN, HANNA, RIPOLI, CRISTIAN, GULISANO, WALTER, GONZALEZ, JUANA, TIAN, HUILAI, COSTA, JONATHON, LOPEZ, PATRICIA, DAVIDOWITZ, ELIOT, YU, WAI HAUNG, HAROUTUNIAN, VAHRAM, BROWN, LEWIS, PALMERI, AGOSTINO, SIGURDSSON, EINAR, DUFF, KAREN, TEICH, ANDREW FRANKLIN, HONIG, LAWRENCE, SIERKS, MICHAEL, MOE, JAMES, D’ADAMIO, LUCIANO, GRASSI, CLAUDIO, KANAAN, NICHOLAS, FRASER, PAUL, ARANCIO, OTTAVIO, FA', MAURO, PUZZO, DANIELA, PIACENTINI, ROBERTO, STANISZEWSKI, AGNIESZKA, ZHANG, HONG, BALTRONS, MARIA ANTONIA, LI PUMA, DOMENICA DONATELLA, CHATTERJEE, ISHITA, LI, JIN, SAEED, FAISAL, BERMAN, HANNA, RIPOLI, CRISTIAN, GULISANO, WALTER, GONZALEZ, JUANA, TIAN, HUILAI, COSTA, JONATHON, LOPEZ, PATRICIA, DAVIDOWITZ, ELIOT, YU, WAI HAUNG, HAROUTUNIAN, VAHRAM, BROWN, LEWIS, PALMERI, AGOSTINO, SIGURDSSON, EINAR, DUFF, KAREN, TEICH, ANDREW FRANKLIN, HONIG, LAWRENCE, SIERKS, MICHAEL, MOE, JAMES, D’ADAMIO, LUCIANO, GRASSI, CLAUDIO, KANAAN, NICHOLAS, FRASER, PAUL, and ARANCIO, OTTAVIO

Published
2016

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