1. Detection of tris-(2,3-dibromopropyl) isocyanurate as a neuronal toxicant in environmental samples using neuronal toxicity-directed analysis
- Author
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GuangBo, Qu, JianBo, Shi, ZhuoNa, Li, Ting, Ruan, JianJie, Fu, Pu, Wang, Wang, Thanh, GuiBin, Jiang, GuangBo, Qu, JianBo, Shi, ZhuoNa, Li, Ting, Ruan, JianJie, Fu, Pu, Wang, Wang, Thanh, and GuiBin, Jiang
- Abstract
Neuronal toxic pollutants in environment possess hazards to human health. It is essential to determine the causative neuronal toxicants in environmental samples. In the present study, viability of primary cultured cerebellar granule neurons (CGNs), combined with sample extraction, chemical fractionation and identification, was applied for screening acid-resistant neuronal toxic substances in environmental samples. River sediments and agricultural soils along the river near a brominated flame retardant (BFR) manufacturing plant in South China were collected to screen the key neuronal toxicants. The results indicated that the manufacturing plant was a source of neuronal toxicity risks. In the sediment and soil near the plant, one of the causative toxicants was identified as tris-(2,3-dibromopropyl) isocyanurate (TBC) using HPLC-MS/MS. In addition, an unknown chemical possibly causing significant neuronal toxicity was isolated from all the soil samples in the region., Funding Agencies:National Basic Research Program of China 2009CB421605National Natural Science Foundation of China 20890111 20921063 20931160427Ministry of Science and Technology of China 2008IM041300
- Published
- 2011
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