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2. One-way membrane trafficking of SOS in receptor-triggered Ras activation

Author

Roose, Jeroen, Roose, Jeroen, Christensen, SM, Tu, HL, Jun, JE, Alvarez, S, Triplet, MG, Iwig, JS, Yadav, KK, Bar-Sagi, D, Roose, JP, Groves, JT, Roose, Jeroen, Roose, Jeroen, Christensen, SM, Tu, HL, Jun, JE, Alvarez, S, Triplet, MG, Iwig, JS, Yadav, KK, Bar-Sagi, D, Roose, JP, and Groves, JT

Abstract

SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2-SOS binding kinetics. However, SOS has multiple

Published
2016

3. One-way membrane trafficking of SOS in receptor-triggered Ras activation

Author

Roose, Jeroen, Roose, Jeroen, Christensen, SM, Tu, HL, Jun, JE, Alvarez, S, Triplet, MG, Iwig, JS, Yadav, KK, Bar-Sagi, D, Roose, JP, Groves, JT, Roose, Jeroen, Roose, Jeroen, Christensen, SM, Tu, HL, Jun, JE, Alvarez, S, Triplet, MG, Iwig, JS, Yadav, KK, Bar-Sagi, D, Roose, JP, and Groves, JT

Abstract

SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced by rapidly reversible Grb2-SOS binding kinetics. However, SOS has multiple

Published
2016

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