Search

Your search keyword '"Goh, Brian K. P."' showing total 4 results
Start Over Author "Goh, Brian K. P." Database OAIster
4 results on '"Goh, Brian K. P."'

1. The road to tailored adjuvant chemotherapy for all four non-pancreatic periampullary cancers: An international multimethod cohort study

Author

Uijterwijk, Bas A., Lemmers, Daniel H., Ghidini, Michele, Wilmink, Johanna W., Zaniboni, Alberto, Fusai, Giuseppe Kito, Zerbi, Alessandro, Koerkamp, Bas Groot, Luyer, Misha, Ghorbani, Poya, Salvia, Roberto, White, Steven, Ielpo, Benedetto, Goh, Brian K. P., Boggi, Ugo, Kazemier, Geert, House, Michael G., Mavroeidis, Vasileios K., Björnsson, Bergthor, Mazzola, Michele, Serradilla, Mario, Korkolis, Dimitris, Alseidi, Adnan, Roberts, Keith J., Soonawalla, Zahir, Pessaux, Patrick, Fisher, William E., Koek, Sharnice, Kent, Tara S., Vladimirov, Miljana, Bolm, Louisa, Jamieson, Nigel, Dalla Valle, Raffaele, Kleeff, Jorg, Mazzotta, Alessandro, Munoz, Miguel Angel Suarez, Cabus, Santiago Sanchez, Ball, Chad G., Berger, Adam C., Ferarri, Clarissa, Besselink, Marc G., Hilal, Mohammed Abu, Uijterwijk, Bas A., Lemmers, Daniel H., Ghidini, Michele, Wilmink, Johanna W., Zaniboni, Alberto, Fusai, Giuseppe Kito, Zerbi, Alessandro, Koerkamp, Bas Groot, Luyer, Misha, Ghorbani, Poya, Salvia, Roberto, White, Steven, Ielpo, Benedetto, Goh, Brian K. P., Boggi, Ugo, Kazemier, Geert, House, Michael G., Mavroeidis, Vasileios K., Björnsson, Bergthor, Mazzola, Michele, Serradilla, Mario, Korkolis, Dimitris, Alseidi, Adnan, Roberts, Keith J., Soonawalla, Zahir, Pessaux, Patrick, Fisher, William E., Koek, Sharnice, Kent, Tara S., Vladimirov, Miljana, Bolm, Louisa, Jamieson, Nigel, Dalla Valle, Raffaele, Kleeff, Jorg, Mazzotta, Alessandro, Munoz, Miguel Angel Suarez, Cabus, Santiago Sanchez, Ball, Chad G., Berger, Adam C., Ferarri, Clarissa, Besselink, Marc G., and Hilal, Mohammed Abu

Abstract

Background: Despite differences in tumour behaviour and characteristics between duodenal adenocarcinoma (DAC), the intestinal (AmpIT) and pancreatobiliary (AmpPB) subtype of ampullary adenocarcinoma and distal cholangiocarcinoma (dCCA), the effect of adjuvant chemotherapy (ACT) on these cancers, as well as the optimal ACT regimen, has not been comprehensively assessed. This study aims to assess the influence of tailored ACT on DAC, dCCA, AmpIT, and AmpPB. Patients and methods: Patients after pancreatoduodenectomy for non-pancreatic periampullary adenocarcinoma were identified and collected from 36 tertiary centres between 2010 - 2021. Per non-pancreatic periampullary tumour type, the effect of adjuvant chemotherapy and the main relevant regimens of adjuvant chemotherapy were compared. The primary outcome was overall survival (OS). Results: The study included a total of 2866 patients with DAC (n = 330), AmpIT (n = 765), AmpPB (n = 819), and dCCA (n = 952). Among them, 1329 received ACT, and 1537 did not. ACT was associated with significant improvement in OS for AmpPB (P = 0.004) and dCCA (P < 0.001). Moreover, for patients with dCCA, capecitabine mono ACT provided the greatest OS benefit compared to gemcitabine (P = 0.004) and gemcitabine - cisplatin (P = 0.001). For patients with AmpPB, no superior ACT regime was found (P > 0.226). ACT was not associated with improved OS for DAC and AmpIT (P = 0.113 and P = 0.445, respectively). Discussion: Patients with resected AmpPB and dCCA appear to benefit from ACT. While the optimal ACT for AmpPB remains undetermined, it appears that dCCA shows the most favourable response to capecitabine monotherapy. Tailored adjuvant treatments are essential for enhancing prognosis across all four non-pancreatic periampullary adenocarcinomas.

Published
2024
Full Text
View/download PDF

2. Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review

Author

Uijterwijk, Bas A., Lemmers, Daniel H., Fusai, Giuseppe Kito, Zerbi, Alessandro, Salvia, Roberto, Sparrelid, Ernesto, White, Steven, Björnsson, Bergthor, Mavroeidis, Vasileios K., Roberts, Keith J., Mazzola, Michele, Cabus, Santiago Sanchez, Soonawalla, Zahir, Korkolis, Dimitris, Serradilla, Mario, Pessaux, Patrick, Luyer, Misha, Mowbray, Nicholas, Ielpo, Benedetto, Mazzotta, Alessandro, Kleeff, Jorg, Boggi, Ugo, Munoz, Miguel Angel Suarez, Goh, Brian K. P., Andreotti, Elena, Wilmink, Hanneke, Ghidini, Michele, Zaniboni, Alberto, Verbeke, Caroline, Adsay, Volkan, Bianchi, Denise, Besselink, Marc G., Abu Hilal, Mohammed, International Study Group on Non-Pancreatic Periampullary Cancer (ISGACA), Uijterwijk, Bas A., Lemmers, Daniel H., Fusai, Giuseppe Kito, Zerbi, Alessandro, Salvia, Roberto, Sparrelid, Ernesto, White, Steven, Björnsson, Bergthor, Mavroeidis, Vasileios K., Roberts, Keith J., Mazzola, Michele, Cabus, Santiago Sanchez, Soonawalla, Zahir, Korkolis, Dimitris, Serradilla, Mario, Pessaux, Patrick, Luyer, Misha, Mowbray, Nicholas, Ielpo, Benedetto, Mazzotta, Alessandro, Kleeff, Jorg, Boggi, Ugo, Munoz, Miguel Angel Suarez, Goh, Brian K. P., Andreotti, Elena, Wilmink, Hanneke, Ghidini, Michele, Zaniboni, Alberto, Verbeke, Caroline, Adsay, Volkan, Bianchi, Denise, Besselink, Marc G., Abu Hilal, Mohammed, and International Study Group on Non-Pancreatic Periampullary Cancer (ISGACA)

Abstract

Background: Standard lymphadenectomy for pancreatoduodenectomy is defined for pancreatic ductal adenocarcinoma and adopted for patients with non-pancreatic periampullary cancer (NPPC), ampullary adenocarcinoma (AAC), distal cholangiocarcinoma (dCCA), or duodenal adenocarcinoma (DAC). This study aimed to compare the patterns of lymph node metastases among the different NPPCs in a large series and in a systematic review to guide the discussion on surgical lymphadenectomy and pathology assessment. Methods: This retrospective cohort study included patients after pancreatoduodenectomy for NPPC with at least one lymph node metastasis (2010-2021) from 24 centers in nine countries. The primary outcome was identification of lymph node stations affected in case of a lymph node metastasis per NPPC. A separate systematic review included studies on lymph node metastases patterns of AAC, dCCA, and DAC. Results: The study included 2367 patients, of whom 1535 had AAC, 616 had dCCA, and 216 had DAC. More patients with pancreatobiliary type AAC had one or more lymph node metastasis (67.2% vs 44.8%; P < 0.001) compared with intestinal-type, but no differences in metastasis pattern were observed. Stations 13 and 17 were most frequently involved (95%, 94%, and 90%). Whereas dCCA metastasized more frequently to station 12 (13.0% vs 6.4% and 7.0%, P = 0.005), DAC metastasized more frequently to stations 6 (5.0% vs 0% and 2.7%; P < 0.001) and 14 (17.0% vs 8.4% and 11.7%, P = 0.015). Conclusion: This study is the first to comprehensively demonstrate the differences and similarities in lymph node metastases spread among NPPCs, to identify the existing research gaps, and to underscore the importance of standardized lymphadenectomy and pathologic assessment for AAC, dCCA, and DAC.

Published
2024
Full Text
View/download PDF

3. Different Periampullary Types and Subtypes Leading to Different Perioperative Outcomes of Pancreatoduodenectomy: Reality and Not a Myth; An International Multicenter Cohort Study

Author

Uijterwijk, Bas A., Lemmers, Daniel H., Fusai, Giuseppe Kito, Koerkamp, Bas Groot, Koek, Sharnice, Zerbi, Alessandro, Sparrelid, Ernesto, Boggi, Ugo, Luyer, Misha, Ielpo, Benedetto, Salvia, Roberto, Goh, Brian K. P., Kazemier, Geert, Björnsson, Bergthor, Serradilla-Martin, Mario, Mazzola, Michele, Mavroeidis, Vasileios K., Sanchez-Cabus, Santiago, Pessaux, Patrick, White, Steven, Alseidi, Adnan, Valle, Raffaele Dalla, Korkolis, Dimitris, Bolm, Louisa R., Soonawalla, Zahir, Roberts, Keith J., Vladimirov, Miljana, Mazzotta, Alessandro, Kleeff, Jorg, Suarez Munoz, Miguel Angel, Besselink, Marc G., Hilal, Mohammed Abu, Uijterwijk, Bas A., Lemmers, Daniel H., Fusai, Giuseppe Kito, Koerkamp, Bas Groot, Koek, Sharnice, Zerbi, Alessandro, Sparrelid, Ernesto, Boggi, Ugo, Luyer, Misha, Ielpo, Benedetto, Salvia, Roberto, Goh, Brian K. P., Kazemier, Geert, Björnsson, Bergthor, Serradilla-Martin, Mario, Mazzola, Michele, Mavroeidis, Vasileios K., Sanchez-Cabus, Santiago, Pessaux, Patrick, White, Steven, Alseidi, Adnan, Valle, Raffaele Dalla, Korkolis, Dimitris, Bolm, Louisa R., Soonawalla, Zahir, Roberts, Keith J., Vladimirov, Miljana, Mazzotta, Alessandro, Kleeff, Jorg, Suarez Munoz, Miguel Angel, Besselink, Marc G., and Hilal, Mohammed Abu

Abstract

Simple Summary: For cancer in the periampullary region, surgical resection with pancreatoduodenectomy remains the main curative treatment. Variations in prognosis suggest distinct growth patterns and tissue reactions, potentially influencing complications and perioperative mortality. This study aims to explore the impact of the type of periampullary adenocarcinoma on the perioperative hospital course. This international multicenter cohort study included 30 centers. Patients with duodenal adenocarcinoma (DAC), intestinal-type (AmpIT) and pancreatobiliary-type (AmpPB) ampullary adenocarcinoma, distal cholangiocarcinoma (dCCA), and pancreatic ductal adenocarcinoma (PDAC) were included. The primary outcome was 30-day or in-hospital mortality, and secondary outcomes were major morbidity (Clavien-Dindo 3b >=), clinically relevant post-operative pancreatic fistula (CR-POPF), and length of hospital stay (LOS). Results: Overall, 3622 patients were included in the study (370 DAC, 811 AmpIT, 895 AmpPB, 1083 dCCA, and 463 PDAC). Mortality rates were comparable between DAC, AmpIT, AmpPB, and dCCA (ranging from 3.7% to 5.9%), while lower for PDAC (1.5%, p = 0.013). Major morbidity rate was the lowest in PDAC (4.4%) and the highest for DAC (19.9%, p < 0.001). The highest rates of CR-POPF were observed in DAC (27.3%), AmpIT (25.5%), and dCCA (27.6%), which were significantly higher compared to AmpPB (18.5%, p = 0.001) and PDAC (8.3%, p < 0.001). The shortest LOS was found in PDAC (11 d vs. 14-15 d, p < 0.001). Discussion: In conclusion, this study shows significant variations in perioperative mortality, post-operative complications, and hospital stay among different periampullary cancers, and between the ampullary subtypes. Further research should assess the biological characteristics and tissue reactions associated with each type of periampullary cancer, including subtypes, in order to improve patient management and personalized treatment.

Published
2024
Full Text
View/download PDF

4. Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries

Author

Fusai, Giuseppe Kito, Ferrone, Cristina, Raptis, Dimitri Aristotle, Abu Hilal, Mohamed, Bassi, Claudio, Besselink, Marc, Conlon, Kevin, Davidson, Brian, Del Chiaro, Marco, Dervenis, Christos, Frigerio, Isabella, Falconi, Massimo, Hackert, Thilo, Harrison, Ewen M., Shrikhande, Shailesh V, Siriwardena, Ajith, Smith, Martin, Wolfgang, Christopher, Borakati, Aditya, Balci, Deniz, Elhadi, Muhammed, Salinas, Camila Hidalgo, Machairas, Nikolaos, Marchegiani, Giovanni, Oba, Atsushi, Oberkofler, Christian, Passas, Ioannis, Ravikumar, Reena, Sanchez Velazquez, Patricia, de Santibanes, Martin, Schnitzbauer, Andreas Anton, Soggiu, Fiammetta, Tamburrino, Domenico, Tinguely, Pascale, Wei, Alice, Zachiotis, Marinos, Bentabak, Kamel, Kacimi, Salah Eddine, Nikfarjam, Mehrdad, Shcherba, Aliaksei, Sergeant, Gregory, Coelho, Gustavo, Torres, Orlando, Belev, Nikolay, Fabrice, Burundi, Tang, Ephraim, Martin, Janet, Diaz, Christian, Devaud, Nicolas, Wei, Kongyuan, Hendi, Maher, Mikulic, Danko, Gouvas, Nikolaos, Christophides, Thalis, Nikov, Andrej, Fathallah, Dalia, Saad, Mahmoud, Tammik, Olav, Huhta, Heikki, Sulpice, Laurent, Lupinacci, Renato, Demetrashvili, Zaza, Stavrou, Gregor A., Felekouras, Evangelos, Papaziogas, Vasileios, Misra, Sanjeev, Diponegoro, Erik Prabowo, Hashim, Hashim Talib, Al-Sader, Maytham Al-Juaifari, Satoi, Sohei, Obeidat, Khaled, Mohsen, Maram, Fakhradiyev, Ildar, Han, Ho-Seong, Khalife, Mohamad, Dulskas, Audrius, Bong, Jin, Ghani, Shahi, Eduardo Padilla, Alejandro, Melchor-Ruan, Javier, Erdene, Sarnai, Benkabbou, Amine, Nashidengo, Pueya, Koea, Jonathan, Adeyeye, Ademola, Alatise, Olusegun, Ullah, Sami, Abu Jayyab, Mustafa, Amro, Sarah, Alnammourah, Walaa Mohammed, The, Catherine, Pedziwiatr, Michal, Polkowski, Wojciech, Barbu, Sorin Traian, Karamarkovic, Aleksandar, Galun, Daniel, Goh, Brian K. P., Trotovsek, Blaz, Omoshoro-Jones, Jones, Ielpo, Benedetto, Abdelmageed, Abdelfatah, Sandström, Per A, Cristaudi, Alessandra, Gloor, Beat, Kuemmerli, Christoph, Tishreen, Alaa Hamdan, Chaaban, Mohammad Karam, Wu, Chien Hui, Jen, Po-Chih Yang Fu, Houssem, Ammar, Baraket, Oussama, Coker, Ahmet, Taylor, Mark, Jamieson, Nigel, Iype, Satheesh, Giorgakis, Emmanouil, Qadan, Motaz, Ganai, Sabha, Al-Naggar, Hamza, Chihaka, Onesai, Fusai, Giuseppe Kito, Ferrone, Cristina, Raptis, Dimitri Aristotle, Abu Hilal, Mohamed, Bassi, Claudio, Besselink, Marc, Conlon, Kevin, Davidson, Brian, Del Chiaro, Marco, Dervenis, Christos, Frigerio, Isabella, Falconi, Massimo, Hackert, Thilo, Harrison, Ewen M., Shrikhande, Shailesh V, Siriwardena, Ajith, Smith, Martin, Wolfgang, Christopher, Borakati, Aditya, Balci, Deniz, Elhadi, Muhammed, Salinas, Camila Hidalgo, Machairas, Nikolaos, Marchegiani, Giovanni, Oba, Atsushi, Oberkofler, Christian, Passas, Ioannis, Ravikumar, Reena, Sanchez Velazquez, Patricia, de Santibanes, Martin, Schnitzbauer, Andreas Anton, Soggiu, Fiammetta, Tamburrino, Domenico, Tinguely, Pascale, Wei, Alice, Zachiotis, Marinos, Bentabak, Kamel, Kacimi, Salah Eddine, Nikfarjam, Mehrdad, Shcherba, Aliaksei, Sergeant, Gregory, Coelho, Gustavo, Torres, Orlando, Belev, Nikolay, Fabrice, Burundi, Tang, Ephraim, Martin, Janet, Diaz, Christian, Devaud, Nicolas, Wei, Kongyuan, Hendi, Maher, Mikulic, Danko, Gouvas, Nikolaos, Christophides, Thalis, Nikov, Andrej, Fathallah, Dalia, Saad, Mahmoud, Tammik, Olav, Huhta, Heikki, Sulpice, Laurent, Lupinacci, Renato, Demetrashvili, Zaza, Stavrou, Gregor A., Felekouras, Evangelos, Papaziogas, Vasileios, Misra, Sanjeev, Diponegoro, Erik Prabowo, Hashim, Hashim Talib, Al-Sader, Maytham Al-Juaifari, Satoi, Sohei, Obeidat, Khaled, Mohsen, Maram, Fakhradiyev, Ildar, Han, Ho-Seong, Khalife, Mohamad, Dulskas, Audrius, Bong, Jin, Ghani, Shahi, Eduardo Padilla, Alejandro, Melchor-Ruan, Javier, Erdene, Sarnai, Benkabbou, Amine, Nashidengo, Pueya, Koea, Jonathan, Adeyeye, Ademola, Alatise, Olusegun, Ullah, Sami, Abu Jayyab, Mustafa, Amro, Sarah, Alnammourah, Walaa Mohammed, The, Catherine, Pedziwiatr, Michal, Polkowski, Wojciech, Barbu, Sorin Traian, Karamarkovic, Aleksandar, Galun, Daniel, Goh, Brian K. P., Trotovsek, Blaz, Omoshoro-Jones, Jones, Ielpo, Benedetto, Abdelmageed, Abdelfatah, Sandström, Per A, Cristaudi, Alessandra, Gloor, Beat, Kuemmerli, Christoph, Tishreen, Alaa Hamdan, Chaaban, Mohammad Karam, Wu, Chien Hui, Jen, Po-Chih Yang Fu, Houssem, Ammar, Baraket, Oussama, Coker, Ahmet, Taylor, Mark, Jamieson, Nigel, Iype, Satheesh, Giorgakis, Emmanouil, Qadan, Motaz, Ganai, Sabha, Al-Naggar, Hamza, and Chihaka, Onesai

Abstract

Background: Pancreatic surgery remains associated with high morbidity rates. Although postoperative mortality appears to have improved with specialization, the outcomes reported in the literature reflect the activity of highly specialized centres. The aim of this study was to evaluate the outcomes following pancreatic surgery worldwide. Methods: This was an international, prospective, multicentre, cross-sectional snapshot study of consecutive patients undergoing pancreatic operations worldwide in a 3-month interval in 2021. The primary outcome was postoperative mortality within 90 days of surgery. Multivariable logistic regression was used to explore relationships with Human Development Index (HDI) and other parameters. Results: A total of 4223 patients from 67 countries were analysed. A complication of any severity was detected in 68.7 percent of patients (2901 of 4223). Major complication rates (Clavien-Dindo grade at least IIIa) were 24, 18, and 27 percent, and mortality rates were 10, 5, and 5 per cent in low-to-middle-, high-, and very high-HDI countries respectively. The 90-day postoperative mortality rate was 5.4 per cent (229 of 4223) overall, but was significantly higher in the low-to-middle-HDI group (adjusted OR 2.88, 95 per cent c.i. 1.80 to 4.48). The overall failure-to-rescue rate was 21 percent; however, it was 41 per cent in low-to-middle-compared with 19 per cent in very high-HDI countries. Conclusion: Excess mortality in low-to-middle-HDI countries could be attributable to failure to rescue of patients from severe complications. The authors call for a collaborative response from international and regional associations of pancreatic surgeons to address management related to death from postoperative complications to tackle the global disparities in the outcomes of pancreatic surgery (NCT04652271; ISRCTN95140761)., Funding Agencies|Fiorina Royal Free Charity, London, UK; Swiss Pancreas Foundation, Berne, Switzerland

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results