Author: "Giordano, J" / Database: OAIster - Searchworks@Jio Institute Digital Library Search Results

13 results on '"Giordano, J"'

1. The incremental yield of prenatal exome sequencing over chromosome microarray for congenital heart abnormalities:A systematic review and meta-analysis

Author: Reilly, K., Sonner, S., McCay, N., Rolnik, D. L., Casey, F., Seale, A. N., Watson, C. J., Kan, A., Lai, T. H. T., Chung, B. H. Y., Diderich, K. E. M., Srebniak, M. I., Dempsey, E., Drury, S., Giordano, J., Wapner, R., Kilby, M. D., Chitty, L. S., Mone, F., Reilly, K., Sonner, S., McCay, N., Rolnik, D. L., Casey, F., Seale, A. N., Watson, C. J., Kan, A., Lai, T. H. T., Chung, B. H. Y., Diderich, K. E. M., Srebniak, M. I., Dempsey, E., Drury, S., Giordano, J., Wapner, R., Kilby, M. D., Chitty, L. S., and Mone, F.
Abstract: ObjectivesTo determine the incremental yield of prenatal exome sequencing (PES) over standard testing in fetuses with an isolated congenital heart abnormality (CHA), CHA associated with extra-cardiac malformations (ECMs) and CHA dependent upon anatomical subclassification.MethodsA systematic review of the literature was performed using MEDLINE, EMBASE, Web of Science and grey literature January 2010-February 2023. Studies were selected if they included greater than 20 cases of prenatally diagnosed CHA when standard testing (QF-PCR/chromosome microarray/karyotype) was negative. Pooled incremental yield was determined. PROSPERO CRD 42022364747.ResultsOverall, 21 studies, incorporating 1957 cases were included. The incremental yield of PES (causative pathogenic and likely pathogenic variants) over standard testing was 17.4% (95% CI, 13.5%-21.6%), 9.3% (95% CI, 6.6%-12.3%) and 35.9% (95% CI, 21.0%-52.3%) for all CHAs, isolated CHAs and CHAs associated with ECMs. The subgroup with the greatest yield was complex lesions/heterotaxy; 35.2% (95% CI 9.7%-65.3%). The most common syndrome was Kabuki syndrome (31/256, 12.1%) and most pathogenic variants occurred de novo and in autosomal dominant (monoallelic) disease causing genes (114/224, 50.9%).ConclusionThe likelihood of a monogenic aetiology in fetuses with multi-system CHAs is high. Clinicians must consider the clinical utility of offering PES in selected isolated cardiac lesions.What is already known?Congenital heart abnormalities are the most commonly occurring congenital anomalies and can be associated with chromosomal or monogenic conditions. With the increasing use of fetal sequencing, there is a need to define the association between monogenic conditions and specific cardiac abnormalities, particularly when isolated to facilitate triaging for prenatal sequencing.What does this study add?The incremental yield of prenatal exome sequencing over and above chromosome microarray for congenital heart abnormalities is 9.3% i
Published: 2024

2. Combining Metacognitive Therapy and tDCS: preliminary results in patients with Major Depressive Disorder

Author: Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Vergallito, A, Schiena, G, Maggioni, E, Sciortino, D, Casiraghi, L, Vedani, A, Melloni, M, Caselli, G, Maria Ruggiero, G, Sassaroli, S, Brambilla, P, ROMERO LAURO, L, Alessandra Vergallito, Giandomenico Schiena, Eleonora Maggioni, Domenico Sciortino, Letizia Casiraghi, Anna Vedani, Maria Costanza Melloni, Gabriele Caselli, Giovanni Maria Ruggiero, Sandra Sassaroli, Paolo Brambilla, Leonor Josefina Romero Lauro, Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Vergallito, A, Schiena, G, Maggioni, E, Sciortino, D, Casiraghi, L, Vedani, A, Melloni, M, Caselli, G, Maria Ruggiero, G, Sassaroli, S, Brambilla, P, ROMERO LAURO, L, Alessandra Vergallito, Giandomenico Schiena, Eleonora Maggioni, Domenico Sciortino, Letizia Casiraghi, Anna Vedani, Maria Costanza Melloni, Gabriele Caselli, Giovanni Maria Ruggiero, Sandra Sassaroli, Paolo Brambilla, and Leonor Josefina Romero Lauro
Abstract: Background and aim: Transcranial direct current stimulation (tDCS) and metacognitive therapy (MCT) can reduce depressive symptoms as monotherapies or associated with pharmacological treatment. Here, we investigated the effectiveness of combining these treatments in a group of patients with major depressive disorder (MDD). Methods: So far, fourteen participants (10 females, Mage 43 ± 12) out of N= 54 estimated sample size were recruited at the Department of Neuroscience and Mental Health – Fondazione IRRCS Ca’ Granda Ospedale Maggiore Policlinico of Milano. All participants were under pharmacological treatment. They were randomly assigned to three groups receiving (i) real tDCS + sham MCT (n= 7); (ii) sham tDCS + MCT (n = 6) (iii) real tDCS + MCT (n= 1). The treatment lasted eight weeks, in which participants had one weekly MCT (groups ii and iii) or clinical interview session (group i) following the tDCS. TDCS was combined with attentional training (20 minutes, 1.5 mA, anode over the left dorsolateral prefrontal cortex) and took place three times a week for the first three weeks and then once a week. Clinical standardized questionnaires measuring depressive symptoms, anxiety, worry, rumination, and meta-beliefs were administered before and after the treatment, two weeks, three, six, and twelve months after treatment’s end. Results: Due to sampling distribution, mixed effects models were run, including time and only two groups as fixed factors (i and ii) and participants’ random intercept. Outcome measures revealed an effect of time, showing symptoms reduction after the treatment. Crucially, our results suggested a more robust reduction of worry and negative beliefs in the group receiving MCT compared to the one receiving only tDCS. Conclusions: despite preliminary, our results suggest that MCT can effectively reduce core symptoms contributing to the development and maintenance of MDD. Completing data collection will allow disentangling whether tDCS can boost this ef
Published: 2023

3. Neural plasticity in schizophrenia: an integrated approach for rehabilitation by means of TMS and cognitive remediation training

Author: Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Torriero, S, Gesi, C, Vergallito, A, Mencacci, C, Dell'Osso, B, Sara Torriero, Camilla Gesi, Alessandra Vergallito, Claudio Mencacci, Bernardo Dell'Osso, Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Torriero, S, Gesi, C, Vergallito, A, Mencacci, C, Dell'Osso, B, Sara Torriero, Camilla Gesi, Alessandra Vergallito, Claudio Mencacci, and Bernardo Dell'Osso
Abstract: Schizophrenia is a severe and disabling psychiatric disorder probably based on complex pathophysiological mechanisms of reduced inhibition, impaired connectivity and reduced plasticity in neural networks. Beside clinical symptomatology, a core feature of schizophrenia is a global cognitive and social disability, which strongly affect patients’ lives and their quality of life. The cognitive impairment involves memory, attention, executive functions, language, facial emotion recognition and theory of mind abilities. Cognitive remediation strategies, in addition to pharmacological and psychological treatments, has received increasing attention in recent years , as well as the use of non-invasive brain stimulation techniques such as TMS, which have demonstrated promising therapeutic potential. In order to evaluate the efficacy of TMS to induce improvements in cognitive functioning in schizophrenia, 16 patients were submitted to effective or sham iTBS over the left dorsolateral prefrontal cortex during 3 consecutive weeks. In half of patients the neuromodulation was combined with daily cognitive remediation training (Cogpack software), administered immediately after the application of TMS. Clinical, cognitive and social functioning were tested at baseline and at different timepoints after conclusion of the rehabilitation protocol (immediately after the 3 weeks protocol, and after 1, 3 and 6 months). The preliminary results indicate that the proposed TMS protocol induced significant improvements in global cognition, in particular in the domains subserved by the prefrontal cortex and the interconnected regions. In addition, patients submitted to TMS showed major benefits after 1 month from brain stimulation, suggesting that TMS induced long-lasting plastic changes.
Published: 2023

4. The efficacy of Non-invasive Brain Stimulation techniques on Chronic Primary Pain disorders: a systematic review and meta-analysis

Author: Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Telesca, A, Vergallito, A, Gallucci, A, Romero Lauro, L, Alessandra Telesca, Alessandra Vergallito, Alessia Gallucci, Leonor J. Romero Lauro, Fecteau, S, Bikson, M, Chandler, J, Giordano, J, Telesca, A, Vergallito, A, Gallucci, A, Romero Lauro, L, Alessandra Telesca, Alessandra Vergallito, Alessia Gallucci, and Leonor J. Romero Lauro
Abstract: Background: Chronic Primary Pain (CPP) is characterized by an intense pain, not explained by lesions/damage to the nervous system, lasting for more than three months. Not all CPP patients benefit from standard pharmacological therapies nor are suitable for invasive neurosurgery treatments. Non-invasive brain stimulation (NIBS) uses cortical stimulation to reduce pain by directly altering brain activity, and its effects in treating CPP is still unclear. Objectives: We aimed at evaluating NIBS effects on CPP patients. Methods: A PRISMA systematic review was performed in PubMed, Embase, Scopus and Web of Science in May 2021. English-written, original studies measuring the effects of NIBS on pain perception were considered. The quality of studies was assessed with the Cochrane Risk of Bias and the Robins-I. The meta-analysis was conducted only on sham-controlled double-blinded studies. The pain intensity, measured through visual or numerical rating scales, was used as outcome of interest. Results:134 studies were included, comprising 2444 patients and 5 different Primary Pain conditions. The meta-analysis was run on a preliminary cohort of 42 studies. When compared to sham effects, real NIBS induced a significant decrease of pain intensity (SMD −0.59 [CI: −0.85, −0.34]; p < 0.001). Meta-regression analysis did not show any effect of type of NIBS (i.e., rTMS vs tDCS), target region (i.e., DLPFC, M1, S1, dACC, PFC, VC) and protocol type (i.e., excitatory vs inhibitory). Discussions: Our findings show a reduction of perceived pain after real vs sham stimulation. This result was confirmed also separately for tDCS and TMS. The target region, as well as the protocol intensity didn’t influence the results. This suggests that NIBS can be used as an alternative or as a combined approach in CPP treatment, but more randomized clinical trials are needed to further explore the mechanisms underlying its effects.
Published: 2023

5. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Author: Ruffino, M. A., Chan, S., Coughlin, P., Awopetu, A., Stather, P., Lane, T., Theodosiou, D., Ahmed, M. A., Vasudevan, T., Ibrahim, M., Al Maadany, F., Eljareh, M., Alkhafeefi, F. S., Coscas, R., Unal, E. U., Pulli, R., Zaca, S., Angiletta, D., Kotsis, T., Moawad, M., Tozzi, M., Patelis, N., Lazaris, A. M., Chuen, J., Croo, A., Tsolaki, E., Zenunaj, G., Kamal, D., Tolba, M. M., Maresch, M., Khetarpaul, V., Mills, J., Gangwani, G., Elahwal, M., Khalil, R., Azab, M. A., Mahomed, A., Whiston, R., Contractor, U., Esposito, D., Pratesi, C., Giacomelli, E., Troncoso, M. V., Elkouri, S., Johansson, F. G., Dodos, I., Benezit, M., Vidoedo, J., Rocha-Neves, J., Pereira-Neves, A. H., Dias-Neto, M. F., Campos Jacome, A. F., Loureiro, L., Silva, I., Garza-Herrera, R., Canata, V., Bezard, C., Bowser, K., Tobar, J. F., Vera, C. G., Parra, C. S., Lopez, E., Serra, Y. G., Varela, J., Rubio, V., Victoria, G., Johnson, A., O'Banion, L. A., Makar, R., Tantawy, T. G., Storck, M., Jongkind, V., Falah, O., Mcbride, O., Isik, A., Papaioannou, A., Ocke Reis, P. E., Bracale, U. M., Atkins, E., Tinelli, Giovanni, Scott, E., Wales, L., Sivaharan, A., Priona, G., Nesbitt, C., Grainger, T., Shelmerdine, L., Chong, P., Bajwa, A., Arwynck, L., Hadjievangelou, N., Elbasty, A., Rubio, O., Ricardo, M., Ulloa, J. H., Tarazona, M., Pabon, M., Pitoulias, G., Corless, K., Ioannidis, O., Friedrich, O., Van Herzeele, I., Vijaynagar, B., Cohnert, T., Bell, R., Moore, H., Saha, P., Gifford, E., Laine, M., Barkat, A., Karkos, C., Binti Safri, L. S., Buitron, G., Del Castillo, J., Carrera, P., Salinas, N., Biagioni, R. B., Benites, S., Mafla, C. A., Pian, P. M., Albino, P., Serrano, E., Marin, A., Gonzalez, M., Foreroga, M., Russo, A., Reyes, A., Guglielmone, D., Grillo, L., Flumignan, R., Palones, F. G., Silveira, P. G., Ramely, R. B., Edeiken, S., Chetter, I., Green, L., Sudarsanam, A., Lyons, O., Lemmon, G., Neville, R., Castelli, M., Hinojosa, C. A., Carvajal, R. R., Rivera, A., Wong, P., Drudi, L., Perkins, J., Sieunarine, K., Attia, D., Atef, M., Eftychios, L., Weaver, F., Ren, L. C., Alomari, M., Jamjoom, R., Aljarrah, Q., Abbas, A., Alomran, F., Kumar, A., Altoijri, A., Elsanhoury, K. T., Alhumaid, A., Fekry, T., Sekhar, R., Theodoridis, P., Panagiotis, T., Roditis, K., Tsiantoula, P., Antoniou, A., Soler, R., Hasemaki, N., Baili, E., Mpaili, E., Huasen, B., Wallace, T., Duncan, A., Metcalfe, M., Mannoia, K., Bechara, C. F., Tsilimparis, N., Aranson, N., Riding, D., Palena, M., Mcdonnell, C., Mouawad, N. J., Banegas, S., Rossi, P., Oshodi, T., Diaz, R., Afifi, R., Dindyal, S., Thapar, A., Kordzadeh, A., Pullas, G., Lin, S., Davies, C., Darvall, K., Kodama, A., Gooneratne, T., Gunawansa, N., Munoz, A., Jie, N. J., Bradley, N., Al-Jundi, W., Meyer, F., Lee, C., Malina, M., Renton, S., Lui, D., Batchelder, A., Oszkinis, G., Freyrie, A., Giordano, J., Saratzis, N., Tigkiropoulos, K., Kyriakos, S., Popov, G., Cheema, M. U., Lapolla, P., Ling Patricia, Y. C., Ennab, R., Ullery, B. W., Pasenidou, K., Tam, J., Sidel, G., Jayaprakash, V. V., Bennett, L., Hardy, S., Davies, E., Baker, S., Wijesinghe, L., Tam, A., Mccune, K., Chana, M., Lowe, C., Goh, A., Powezka, K., Kyrou, I., Altaf, N., Harkin, D., Travers, H., Cragg, J., Sharif, A., Akhtar, T., Chavez, J. A., Ordonez, C., Mazzurco, M., Choke, E., Asghar, I., Summerour, V., Dunlop, P., Morley, R., Hardy, T., Bevis, P., Cuff, R., Stavroulakis, K., Beropoulis, E., Argyriou, A., Loftus, I., Azhar, B., Sheth, S., Usai, M. V., Choudhry, A., Nicole, K., Boyle, E., Joyce, D., Abdelaty Hassan, M. H., Saltiel, A., Frahm-Jensen, G., Antoniou, G., Elhadi, M., Kimyaghalam, A., Malgor, R., Telve, D., Isaak, A., Schmidli, J., Mckevitt, K., Siddiqui, T., Asciutto, G., Floros, N., Papadopoulos, G., Kafetzakis, A., Koutsias, S. G., Nana, P., Giannoukas, A., Kakkos, S., Moulakakis, K. G., Shafique, N., Jawien, A., Popplewell, M., Imray, C., Abayasekara, K., Rowlands, T., Kuhan, G., Rajagopalan, S., Jaipersad, A., Sadia, U., Kobe, I., Mittapalli, D., Enemosah, I., Behrendt, C. -A., Beck, A., Almudhafer, M., Ancetti, S., Jacobs, D., Jayakumar, P., Malekpour, F., Shalhub, S., Keldiyorov, B., Simon, M., Khashram, M., Rich, N., Shepherd, A., Meecham, L., Doherty, D., Benson, R. A., Tinelli G. (ORCID:0000-0002-2212-3226), Ruffino, M. A., Chan, S., Coughlin, P., Awopetu, A., Stather, P., Lane, T., Theodosiou, D., Ahmed, M. A., Vasudevan, T., Ibrahim, M., Al Maadany, F., Eljareh, M., Alkhafeefi, F. S., Coscas, R., Unal, E. U., Pulli, R., Zaca, S., Angiletta, D., Kotsis, T., Moawad, M., Tozzi, M., Patelis, N., Lazaris, A. M., Chuen, J., Croo, A., Tsolaki, E., Zenunaj, G., Kamal, D., Tolba, M. M., Maresch, M., Khetarpaul, V., Mills, J., Gangwani, G., Elahwal, M., Khalil, R., Azab, M. A., Mahomed, A., Whiston, R., Contractor, U., Esposito, D., Pratesi, C., Giacomelli, E., Troncoso, M. V., Elkouri, S., Johansson, F. G., Dodos, I., Benezit, M., Vidoedo, J., Rocha-Neves, J., Pereira-Neves, A. H., Dias-Neto, M. F., Campos Jacome, A. F., Loureiro, L., Silva, I., Garza-Herrera, R., Canata, V., Bezard, C., Bowser, K., Tobar, J. F., Vera, C. G., Parra, C. S., Lopez, E., Serra, Y. G., Varela, J., Rubio, V., Victoria, G., Johnson, A., O'Banion, L. A., Makar, R., Tantawy, T. G., Storck, M., Jongkind, V., Falah, O., Mcbride, O., Isik, A., Papaioannou, A., Ocke Reis, P. E., Bracale, U. M., Atkins, E., Tinelli, Giovanni, Scott, E., Wales, L., Sivaharan, A., Priona, G., Nesbitt, C., Grainger, T., Shelmerdine, L., Chong, P., Bajwa, A., Arwynck, L., Hadjievangelou, N., Elbasty, A., Rubio, O., Ricardo, M., Ulloa, J. H., Tarazona, M., Pabon, M., Pitoulias, G., Corless, K., Ioannidis, O., Friedrich, O., Van Herzeele, I., Vijaynagar, B., Cohnert, T., Bell, R., Moore, H., Saha, P., Gifford, E., Laine, M., Barkat, A., Karkos, C., Binti Safri, L. S., Buitron, G., Del Castillo, J., Carrera, P., Salinas, N., Biagioni, R. B., Benites, S., Mafla, C. A., Pian, P. M., Albino, P., Serrano, E., Marin, A., Gonzalez, M., Foreroga, M., Russo, A., Reyes, A., Guglielmone, D., Grillo, L., Flumignan, R., Palones, F. G., Silveira, P. G., Ramely, R. B., Edeiken, S., Chetter, I., Green, L., Sudarsanam, A., Lyons, O., Lemmon, G., Neville, R., Castelli, M., Hinojosa, C. A., Carvajal, R. R., Rivera, A., Wong, P., Drudi, L., Perkins, J., Sieunarine, K., Attia, D., Atef, M., Eftychios, L., Weaver, F., Ren, L. C., Alomari, M., Jamjoom, R., Aljarrah, Q., Abbas, A., Alomran, F., Kumar, A., Altoijri, A., Elsanhoury, K. T., Alhumaid, A., Fekry, T., Sekhar, R., Theodoridis, P., Panagiotis, T., Roditis, K., Tsiantoula, P., Antoniou, A., Soler, R., Hasemaki, N., Baili, E., Mpaili, E., Huasen, B., Wallace, T., Duncan, A., Metcalfe, M., Mannoia, K., Bechara, C. F., Tsilimparis, N., Aranson, N., Riding, D., Palena, M., Mcdonnell, C., Mouawad, N. J., Banegas, S., Rossi, P., Oshodi, T., Diaz, R., Afifi, R., Dindyal, S., Thapar, A., Kordzadeh, A., Pullas, G., Lin, S., Davies, C., Darvall, K., Kodama, A., Gooneratne, T., Gunawansa, N., Munoz, A., Jie, N. J., Bradley, N., Al-Jundi, W., Meyer, F., Lee, C., Malina, M., Renton, S., Lui, D., Batchelder, A., Oszkinis, G., Freyrie, A., Giordano, J., Saratzis, N., Tigkiropoulos, K., Kyriakos, S., Popov, G., Cheema, M. U., Lapolla, P., Ling Patricia, Y. C., Ennab, R., Ullery, B. W., Pasenidou, K., Tam, J., Sidel, G., Jayaprakash, V. V., Bennett, L., Hardy, S., Davies, E., Baker, S., Wijesinghe, L., Tam, A., Mccune, K., Chana, M., Lowe, C., Goh, A., Powezka, K., Kyrou, I., Altaf, N., Harkin, D., Travers, H., Cragg, J., Sharif, A., Akhtar, T., Chavez, J. A., Ordonez, C., Mazzurco, M., Choke, E., Asghar, I., Summerour, V., Dunlop, P., Morley, R., Hardy, T., Bevis, P., Cuff, R., Stavroulakis, K., Beropoulis, E., Argyriou, A., Loftus, I., Azhar, B., Sheth, S., Usai, M. V., Choudhry, A., Nicole, K., Boyle, E., Joyce, D., Abdelaty Hassan, M. H., Saltiel, A., Frahm-Jensen, G., Antoniou, G., Elhadi, M., Kimyaghalam, A., Malgor, R., Telve, D., Isaak, A., Schmidli, J., Mckevitt, K., Siddiqui, T., Asciutto, G., Floros, N., Papadopoulos, G., Kafetzakis, A., Koutsias, S. G., Nana, P., Giannoukas, A., Kakkos, S., Moulakakis, K. G., Shafique, N., Jawien, A., Popplewell, M., Imray, C., Abayasekara, K., Rowlands, T., Kuhan, G., Rajagopalan, S., Jaipersad, A., Sadia, U., Kobe, I., Mittapalli, D., Enemosah, I., Behrendt, C. -A., Beck, A., Almudhafer, M., Ancetti, S., Jacobs, D., Jayakumar, P., Malekpour, F., Shalhub, S., Keldiyorov, B., Simon, M., Khashram, M., Rich, N., Shepherd, A., Meecham, L., Doherty, D., Benson, R. A., and Tinelli G. (ORCID:0000-0002-2212-3226)
Abstract: Objective: To document the recovery of vascular services in Europe following the first COVID-19 pandemic peak. Methods: An online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March – May 2020, “period 1”), and then again between May and June (“period 2”) and June and July 2020 (“period 3”). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume. Results: The impact of the pandemic continued to be felt well after countries’ first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence. Conclusion: Centres reported a broad return of services approaching pre-pandemic “normal” by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries.
Published: 2022

6. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial

Author: Ray, K, Colhoun, H, Szarek, M, Baccara-Dinet, M, Bhatt, D, Bittner, V, Budaj, A, Diaz, R, Goodman, S, Hanotin, C, Harrington, R, Jukema, J, Loizeau, V, Lopes, R, Moryusef, A, Murin, J, Pordy, R, Ristic, A, Roe, M, Tunon, J, White, H, Zeiher, A, Schwartz, G, Steg, P, Tricoci, P, Mahaffey, K, Edelberg, J, Lecorps, G, Sasiela, W, Tamby, J, Aylward, P, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, N, Prieto, J, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Ostadal, P, Viigimaa, M, Nieminen, M, Chumburidze, V, Marx, N, Danchin, N, Liberopoulos, E, Montenegro Valdovinos, P, Tse, H, Kiss, R, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, H, Kim, S, Erglis, A, Laucevicius, A, Kedev, S, Yusoff, K, Ramos Lopez, G, Alings, M, Halvorsen, S, Correa Flores, R, Morais, J, Dorobantu, M, Karpov, Y, Chua, T, Fras, Z, Dalby, A, de Silva, H, Hagstrom, E, Landmesser, U, Chiang, C, Sritara, P, Guneri, S, Parkhomenko, A, Moriarty, P, Vogel, R, Chaitman, B, Kelsey, S, Olsson, A, Rouleau, J, Simoons, M, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, E, Alexander, J, Armaganijan, L, Bagai, A, Bahit, M, Brennan, J, Clifton, S, Devore, A, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, R, Hess, C, Hlatky, M, Jordan, J, Knowles, J, Kolls, B, Kong, D, Leonardi, S, Lillis, L, Maron, D, Marcus, J, Mathews, R, Mehta, R, Mentz, R, Moreira, H, Patel, C, Bernardez-Pereira, S, Perkins, L, Povsic, T, Puymirat, E, Schuyler Jones, W, Shah, B, Sherwood, M, Stringfellow, K, Sujjavanich, D, Toma, M, Trotter, C, Van Diepen, S, Wilson, M, Yan, A, Schiavi, L, Garrido, M, Alvarisqueta, A, Sassone, S, Bordonava, A, Alves De Lima, A, Schmidberg, J, Duronto, E, Caruso, O, Novaretto, L, Hominal, M, Montana, O, Caccavo, A, Gomez Vilamajo, O, Lorenzatti, A, Cartasegna, L, Paterlini, G, Mackinnon, I, Caime, G, Amuchastegui, M, Salomone, O, Codutti, O, Jure, H, Bono, J, Hrabar, A, Vallejos, J, Ahuad Guerrero, R, Novoa, F, Patocchi, C, Zaidman, C, Giuliano, M, Dran, R, Vico, M, Carnero, G, Guzman, P, Medrano Allende, J, Garcia Brasca, D, Bustamante Labarta, M, Nani, S, Blumberg, E, Colombo, H, Liberman, A, Fuentealba, V, Luciardi, H, Waisman, G, Berli, M, Garcia Duran, R, Cestari, H, Luquez, H, Giordano, J, Saavedra, S, Zapata, G, Costamagna, O, Llois, S, Waites, J, Collins, N, Soward, A, Hii, C, Shaw, J, Arstall, M, Horowitz, J, Ninio, D, Rogers, J, Colquhoun, D, Oqueli Flores, R, Roberts-Thomson, P, Raffel, O, Lehman, S, Aroney, C, Coverdale, S, Garrahy, P, Starmer, G, Sader, M, Carroll, P, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Delle-Karth, G, Frey, B, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, M, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Kulic, M, Durak-Nalbantic, A, Vulic, D, Muslibegovic, A, Goronja, B, Reis, G, Sousa, L, Nicolau, J, Giorgeto, F, Silva, R, Nigro Maia, L, Rech, R, Rossi, P, Cerqueira, M, Duda, N, Kalil, R, Kormann, A, Abrantes, J, Pimentel Filho, P, Soggia, A, de Santos, M, Neuenschwander, F, Bodanese, L, Michalaros, Y, Eliaschewitz, F, Vidotti, M, Leaes, P, Botelho, R, Kaiser, S, Manenti, E, Precoma, D, Moura Jorge, J, de B Silva, P, Silveira, J, Saporito, W, Marin-Neto, J, Feitosa, G, Ritt, L, de Souza, J, Costa, F, Souza, W, Reis, H, Machado, L, Ayoub, J, Todorov, G, Nikolov, F, Velcheva, E, Tzekova, M, Benov, H, Petranov, S, Tumbev, H, Shehova-Yankova, N, Markov, D, Raev, D, Mollov, M, Kichukov, K, Ilieva-Pandeva, K, Ivanova, R, Gospodinov, M, Mincheva, V, Lazov, P, Dimov, B, Senaratne, M, Stone, J, Kornder, J, Pearce, S, Dion, D, Savard, D, Pesant, Y, Pandey, A, Robinson, S, Gosselin, G, Vizel, S, Hoag, G, Bourgeois, R, Morisset, A, Sabbah, E, Sussex, B, Kouz, S, Macdonald, P, Diaz, A, Michaud, N, Fell, D, Leung, R, Vuurmans, T, Lai, C, Nigro, F, Davies, R, Nogareda, G, Vijayaraghavan, R, Ducas, J, Lepage, S, Mehta, S, Cha, J, Dupuis, R, Fong, P, Lutchmedial, S, Rodes-Cabau, J, Fadlallah, H, Cleveland, D, Huynh, T, Bata, I, Hameed, A, Pincetti, C, Potthoff, S, Acevedo, M, Aguirre, A, Vejar, M, Yanez, M, Araneda, G, Fernandez, M, Perez, L, Varleta, P, Florenzano, F, Huidobro, L, Raffo, C, Olivares, C, Nahuelpan, L, Montecinos, H, Chen, J, Dong, Y, Huang, W, Wang, J, Huang, S, Yao, Z, Li, X, Cui, L, Lin, W, Sun, Y, Li, J, Zhang, X, Zhu, H, Chen, D, Huang, L, Dong, S, Su, G, Xu, B, Su, X, Cheng, X, Lin, J, Zong, W, Li, H, Feng, Y, Xu, D, Yang, X, Ke, Y, Lin, X, Zhang, Z, Zheng, Z, Luo, Z, Chen, Y, Ding, C, Zhong, Y, Zheng, Y, Peng, D, Zhao, S, Li, Y, Liu, X, Wei, M, Liu, S, Yu, Y, Qu, B, Jiang, W, Zhou, Y, Zhao, X, Yuan, Z, Guo, Y, Xu, X, Shi, X, Ge, J, Fu, G, Bai, F, Fang, W, Shou, X, Xiang, M, Lu, Q, Zhang, R, Zhu, J, Xu, Y, Fan, Z, Li, T, Wu, C, Jaramillo, N, Sanchez Vallejo, G, Luna Botia, D, Botero Lopez, R, Molina De Salazar, D, Cadena Bonfanti, A, Cotes Aroca, C, Diego Higuera, J, Blanquicett, M, Barrera Silva, S, Garcia Lozada, H, Coronel Arroyo, J, Accini Mendoza, J, Fernandez Ruiz, R, Quintero Ossa, A, Manzur Jatin, F, Sotomayor Herazo, A, Castellanos Parada, J, Suarez Arambula, R, Urina Triana, M, Fernandez Trujillo, A, Strozzi, M, Car, S, Jeric, M, Milicic, D, Bencic, M, Pintaric, H, Prvulovic, D, Sikic, J, Persic, V, Mileta, D, Stambuk, K, Babic, Z, Tomulic, V, Lukenda, J, Mejic-Krstulovic, S, Starcevic, B, Spinar, J, Horak, D, Velicka, Z, Stasek, J, Alan, D, Machova, V, Linhart, A, Novotny, V, Kaucak, V, Rokyta, R, Naplava, R, Coufal, Z, Adamkova, V, Podpera, I, Zizka, J, Motovska, Z, Marusincova, I, Svab, P, Heinc, P, Kuchar, J, Povolny, P, Matuska, J, Poulsen, S, Raungaard, B, Clemmensen, P, Bang, L, May, O, Bottcher, M, Hove, J, Frost, L, Gislason, G, Larsen, J, Betton Johansen, P, Hald, F, Johansen, P, Jeppesen, J, Nielsen, T, Kristensen, K, Walichiewicz, P, Lomholdt, J, Klausen, I, Nielsen, P, Davidsen, F, Videbaek, L, Soots, M, Vahula, V, Hedman, A, Soopold, U, Martsin, K, Jurgenson, T, Kristjan, A, Helsinki, J, Vikman, S, Huikuri, H, Airaksinen, J, Coste, P, Ferrari, E, Morel, O, Montalescot, G, Machecourt, J, Barone-Rochette, G, Mansourati, J, Cottin, Y, Leclercq, F, Belhassane, A, Delarche, N, Boccara, F, Paganelli, F, Clerc, J, Schiele, F, Aboyans, V, Probst, V, Berland, J, Lefevre, T, Citron, B, Khintibidze, I, Shaburishvili, T, Pagava, Z, Ghlonti, R, Lominadze, Z, Khabeishvili, G, Hemetsberger, R, Edward, K, Rauch-Krohnert, U, Stratmann, M, Appel, K, Schmidt, E, Omran, H, Stellbrink, C, Dorsel, T, Lianopoulos, E, Vohringer, H, Marx, R, Zirlik, A, Schellenberg, D, Heitzer, T, Laufs, U, Werner, C, Gielen, S, Nuding, S, Winkelmann, B, Behrens, S, Sydow, K, Karakas, M, Simonis, G, Muenzel, T, Werner, N, Leggewie, S, Bocker, D, Braun-Dullaeus, R, Toursarkissian, N, Jeserich, M, Weissbrodt, M, Schaeufele, T, Weil, J, Voller, H, Waltenberger, J, Natour, M, Schmitt, S, Muller-Wieland, D, Steiner, S, Heidenreich, L, Offers, E, Gremmler, U, Killat, H, Rieker, W, Patsilinakos, S, Kartalis, A, Manolis, A, Sionis, D, Chachalis, G, Skoumas, I, Athyros, V, Vardas, P, Parthenakis, F, Alexopoulos, D, Hahalis, G, Lekakis, J, Hatzitolios, A, Fausto Ovando, S, Arango Benecke, J, Rodriguez De Leon, E, Yan, B, Siu, D, Turi, T, Merkely, B, Ungi, I, Lupkovics, G, Nagy, L, Katona, A, Edes, I, Muller, G, Horvath, I, Kapin, T, Szigeti, Z, Falukozy, J, Kumbla, M, Sandhu, M, Annam, S, Proddutur, N, Regella, R, Premchand, R, Mahajan, A, Pawar, S, Abhyanakar, A, Kerkar, P, Govinda, R, Oomman, A, Sinha, D, Patil, S, Kahali, D, Sawhney, J, Joshi, A, Chaudhary, S, Harkut, P, Guha, S, Porwal, S, Jujjuru, S, Pothineni, R, Monteiro, M, Khan, A, Iyengar, S, Grewal, J, Chopda, M, Fulwani, M, Patange, A, Sachin, P, Chopra, V, Goyal, N, Shinde, R, Manakshe, G, Patki, N, Sethi, S, Munusamy, V, Karna, S, Thanvi, S, Adhyapak, S, Patil, C, Pandurangi, U, Mathur, R, Gupta, J, Kalashetti, S, Bhagwat, A, Raghuraman, B, Yerra, S, Bhansali, P, Borse, R, Rahul, P, Das, S, Kumar, V, Abdullakutty, J, Saathe, S, Palimkar, P, Sathe, S, Atar, S, Shechter, M, Mosseri, M, Arbel, Y, Ehud, C, Ofer, H, Lotan, C, Rosenschein, U, Katz, A, Henkin, Y, Francis, A, Klutstein, M, Nikolsky, E, Zukermann, R, Turgeman, Y, Halabi, M, Marmor, A, Kornowski, R, Jonas, M, Amir, O, Hasin, Y, Rozenman, Y, Fuchs, S, Zvi, V, Hussein, O, Gavish, D, Vered, Z, Caraco, Y, Elias, M, Tov, N, Wolfovitz, E, Lishner, M, Elias, N, Piovaccari, G, De Pellegrin, A, Garbelotto, R, Guardigli, G, Marco, V, Licciardello, G, Auguadro, C, Scalise, F, Cuccia, C, Salvioni, A, Musumeci, G, Senni, M, Calabro, P, Novo, S, Faggiano, P, Metra, M, De Cesare, N, Berti, S, Cavallini, C, Puccioni, E, Galvani, M, Tespili, M, Piatti, P, Palvarini, M, De Luca, G, Violini, R, De Leo, A, Olivari, Z, Perrone Filardi, P, Ferratini, M, Racca, V, Dai, K, Shimatani, Y, Kamiya, H, Ando, K, Takeda, Y, Morino, Y, Hata, Y, Kimura, K, Kishi, K, Michishita, I, Uehara, H, Higashikata, T, Hirayama, A, Hirooka, K, Doi, Y, Sakagami, S, Taguchi, S, Koike, A, Fujinaga, H, Koba, S, Kozuma, K, Kawasaki, T, Ono, Y, Shimizu, M, Katsuda, Y, Wada, A, Shinke, T, Ako, J, Fujii, K, Takahashi, T, Sakamoto, T, Nakao, K, Furukawa, Y, Sugino, H, Tamura, R, Mano, T, Uematsu, M, Utsu, N, Ito, K, Haraguchi, T, Sato, K, Ueda, Y, Nishibe, A, Fujimoto, K, Masutani, M, Yoon, J, Park, H, Chae, I, Kim, M, Jeong, M, Rha, S, Kim, C, Hong, T, Tahk, S, Kim, Y, Busmane, A, Pontaga, N, Strelnieks, A, Mintale, I, Sime, I, Petrulioniene, Z, Kavaliauskiene, R, Jurgaitiene, R, Sakalyte, G, Slapikas, R, Norkiene, S, Misonis, N, Kibarskis, A, Kubilius, R, Bojovski, S, Lozance, N, Kjovkaroski, A, Doncovska, S, Ong, T, Kasim, S, Maskon, O, Kandasamy, B, Liew, H, Wan Mohamed, W, Garcia Castillo, A, Carrillo Calvillo, J, Fajardo Campos, P, Nunez Fragoso, J, Bayram Llamas, E, Alcocer Gamba, M, Carranza Madrigal, J, Gonzalez Salas, L, Lopez Rosas, E, Gonzalez Diaz, B, Salcido Vazquez, E, Nacoud 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Y., Tang I-Shing J., Micko K., Nociar J., Pella D., Fulop P., Hranai M., Palka J., Mazur J., Majercak I., Dzupina A., Fazekas F., Gonsorcik J., Bugan V., Selecky J., Kamensky G., Strbova J., Smik R., Dukat A., Zuran I., Poklukar J., Cernic Suligoj N., Cevc M., Cyster H. P., Ranjith N., Corbett C., Bayat J., Makotoko E. M., du Toit Theron H., Kapp I. E., de V Basson M. M., Lottering H., Van Aswegen D., Van Zyl L. J., Sebastian P. J., Pillay T., Saaiman J. A., Commerford P. J., Cassimjee S., Riaz G., Ebrahim I. O., Sarvan M., Mynhardt J. H., Reuter H., Moodley R., Vida M., Cequier Fillat A. R., Bodi Peris V., Fuentes Jimenez F., Marin F., Cruz Fernandez J. M., Hidalgo Urbano R. J., Gil-Extremera B., Toledo P., Worner Diz F., Garcia-Dorado D., Iniguez A., Gonzalez-Juanatey J. R., Fernandez Portales J., Civeira Murillo F., Matas Pericas L., Zamorano J. L., De Mora Martin M., Bruguera Cortada J., Alonso Martin J. J., Serrano Antolin J. M., De Berrazueta Fernandez J. R., Vazquez de Prada J. A., Diaz Fernandez J. F., Garcia Lledo J. A., Cosin Sales J., Botas Rodriguez J., Gusi Tragant G., Benedicto A., Gonzalez-Juanatey C., Camprubi Potau M., Plaza Perez I., De La Tassa C. M., Loma-Osorio Rincon P., Balaguer Recena J., Escudier J. M., Payeras A. C., Alonso Orcajo N., Valdivielso P., Constantine G., Haniffa R., Tissera N., Amarasekera S., Ponnamperuma C., Fernando N., Fernando K., Jayawardena J., Wijeyasingam S., Ranasinghe G., Ekanayaka R., Mendis S., Senaratne V., Mayurathan G., Sirisena T., Rajapaksha A., Herath J. I., Amarasena N., Berglund S., Rasmanis G., Vedin O., Witt N., Mourtzinis G., Nicol P., Hansen O., Romeo S., Agergaard Jensen S., Torstensson I., Ahremark U., Sundelin T., Moccetti T., Muller C., Mach F., Binde R., Tsai W. -C., Ueng K. -C., Lai W. -T., Liu M. -E., Hwang J. -J., Yin W. -H., Hsieh I. -C., Hsieh M. -J., Lin W. H., Kuo J. -Y., Huang T. -Y., Fang C. -Y., Kaewsuwanna P., Soonfuang W., Jintapakorn W., Sukonthasarn A., Wongpraparut N., Sastravaha K., Sansanayudh N., Kehasukcharoen W., Piyayotai D., Chotnoparatpat P., Camsari A., Kultursay H., Mutlu B., Ersanli M., Demirtas M., Kirma C., Ural E., Koldas L., Karpenko O., Prokhorov A., Vakaluyk I., Myshanych H., Reshotko D., Batushkin V., Rudenko L., Kovalskyi I., Kushnir M., Tseluyko V., Mostovoy Y., Stanislavchuk M., Kyiak Y., Karpenko Y., Malynovsky Y., Klantsa A., Kutniy O., Amosova E., Tashchuk V., Leshchuk O., Rishko M., Kopytsya M., Yagensky A., Vatutin M., Bagriy A., Barna O. M., Ushakov O., Dzyak G., Goloborodko B., Rudenko A., Zheleznyy V., Trevelyan J., Zaman A., Lee K., Moriarty A., Aggarwal R. K., Clifford P., Wong Y. -K., Iqbal S. M., Subkovas E., Braganza D., Sarkar D., Storey R., Griffiths H., McClure S., Muthusamy R., Smith S., Kurian J., Levy T., Barr C., Kadr H., Gerber R., Simaitis A., Soran H., Mathur A., Brodison A., Ayaz M., Cheema M., Oliver R., Thackray S., Mudawi T., Rahman G., Sultan A., Sharman D., Sprigings D., Butler R., Wilkinson P., Lip G. Y., Halcox J., Gallagher S., Ossei-Gerning N., Vardi G., Baldari D., Brabham D., Treasure II C., Dahl C., Palmer B., Wiseman A., Puri S., Mohart A. E., Ince C., Flores E., Wright S., Cheng S. -C., Rosenberg M., Rogers W., Kosinski E., Forgosh L., Waltman J., Khan M., Shoukfeh M., Dagher G., Cambier P., Lieber I., Kumar P., East C., Krichmar P., Hasan M., White L., Knickelbine T., Haldis T., Gillespie E., Amidon T., Suh D., Arif I., Abdallah M., Akhter F., Carlson E., D'Urso M., El-Ahdab F., Nelson W., Moriarty K., Harris B., Cohen S., Carter L., Doty D., Sabatino K., Haddad T., Malik A., Rao S., Mulkay A., Jovin I., Klancke K., Malhotra V., Devarapalli S. K., Koren M., Chandna H., Dodds III G., Goraya T., Bengston J., Janik M., Moran J., Sumner A., Kobayashi J., Davis W., Yazdani S., Pasquini J., Thakkar M., Vedere A., Leimbach W., Rider J., Fenton S., Singh N., Shah A. V., Janosik D., Pepine C., Berman B., Gelormini J., Daniels C., Richard K., Keating F., Kondo N. I., Shetty S., Levite H., Waider W., Takata T., Abu-Fadel M., Shah V., Aggarwal R., Izzo M., Kumar A., Hattler B., Do R., Link C., Bortnick A., Kinzfogl III G., Ghitis A., Larry J., Teufel E., Kuhlman P., Mclaurin B., Zhang W., Thew S., Abbas J., White M., Islam O., Subherwal S., Ranadive N., Vakili B., Gring C., Henderson D., Schuchard T., Farhat N., Kline G., Mahal S., Whitaker J., Speirs S., Andersen R., Daboul N., Horwitz P., Zahr F., Ponce G., Jafar Z., Mcgarvey J., Panchal V., Voyce S., Blok T., Sheldon W., Azizad M. M., Schmalfuss C., Picone M., Pederson R., Herzog W., Friedman K., Lindsey J., Nowins R., Timothy E., Leonard P., Lepor N., El Shahawy M., Weintraub H., Irimpen A., Alonso A., May W., Christopher D., Galski T., Chu A., Mody F., Ramin E., Hodes Z., Rossi J., Rose G., Fairlamb J., Lambert C., Raisinghani A., Abbate A., Vetrovec G., King M., Carey C., Gerber J., Younis L., Park H. T., Vidovich M., Knutson T., Friedman D., Chaleff F., Loussararian A., Rozeman P., Kimmelstiel C., Kuvin J., Silver K., Foster M., Tonnessen G., Espinoza A., Amlani M., Wali A., Malozzi C., Jong G. T., Massey C., Wattanakit K., O'Donnell P. J., Singal D., Jaffrani N., Banuru S., Fisher D., Xenakis M., Perlmutter N., Bhagwat R., Strader J., Blonder R., Akyea-Djamson A., Labroo A., Marais H. J., Claxton E., Weiss R., Kathryn R., Berk M., Rossi P., Joshi P., Khera A., Khaira A. S., Kumkumian G., Lupovitch S., Purow J., Welka S., Hoffman D., Fischer S., Soroka E., Eagerton D., Pancholy S., Ray M., Erenrich N., Farrar M., Pollock S., French W. J., Diamantis S., Guy D., Gimple L., Neustel M., Schwartz S., Pereira E., Albert S., Spriggs D., Strain J., Mittal S., Vo A., Chane M., Hall J., Vijay N., Lotun K., Lester F. M., Nahhas A., Pope T., Nager P., Vohra R., Sharma M., Bashir R., Ahmed H., Berlowitz M., Fishberg R., Barrucco R., Yang E., Radin M., Sporn D., Stapleton D., Eisenberg S., Landzberg J., Mcgough M., Turk S., Schwartz M., Sundram P. S., Jain D., Zainea M., Bayron C., Karlsberg R., Dohad S., Lui H., Keen W., Westerhausen D., Khurana S., Agarwal H., Birchem J., Penny W., Chang M., Murphy S., Henry J., Schifferdecker B., Gilbert J. M., Chalavarya G., Eaton C., Schmedtje J. F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. 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F., Christenson S., Dotani I., Denham D., Macdonell A., Gibson P., Rahman A., Al Joundi T., Assi N., Conrad G., Kotha P., Love M., Giesler G., Rubenstein H., Gamil D., Akright L., Krawczyk J., Cobler J., Wells T., Welker J., Foster R., Gilmore R., Anderson J., Jacoby D., Gardner G., Dandillaya R., Vora K., Kostis J., Hunter J., Laxson D., Ball E., Lopes R., Egydio F., Kawakami A., Oliveira J., Wozniak J., Matthews A., Ratky C., Valiris J., Berdan L., Hepditch A., Quintero K., Rorick T., Westbrook M., Pascual A., Rovito C., Bezault M., Drouet E., Simon T., Alsweiler C., Luyten A., Butters J., Griffith L., Shaw M., Grunberg L., Islam S., Bregeault M. -F., Bougon N., Faustino D., Fontecave S., Murphy J., Verrier M., Agnetti V., Andersen D., Badreddine E., Bekkouche M., Bouancheau C., Brigui I., Brocklehurst M., Cianciarulo J., Devaul D., Domokos S., Gache C., Gobillot C., Guillou S., Healy J., Heath M., Jaiwal G., Javierre C., Labeirie J., Monier M., Morales U., Mrabti A., Mthombeni B., Okan B., Smith L., Sheller J., Sopena S., Pellan V., Benbernou F., Bengrait N., Lamoureux M., Kralova K., Scemama M., Bejuit R., Coulange A., Berthou C., Repincay J., Lorenzato C., Etienne A., Gouet V., Normand M., Ourliac A., Rondel C., Adamo A., Beltran P., Barraud P., Dubois-Gache H., Halle B., Metwally L., Mourgues M., Sotty M., Vincendet M., Cotruta R., Chengyue Z., Fournie-Lloret D., Morrello C., Perthuis A., Picault P., Zobouyan I., Dempsey M. A., and McClanahan M. A.
Abstract: Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring
Published: 2019

7. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

Author: Ramirez-Zamora, A, Giordano, J, Gunduz, A, Alcantara, J, Cagle, JN, Cernera, S, Difuntorum, P, Eisinger, RS, Gomez, J, Long, S, Parks, B, Wong, JK, Chiu, S, Patel, B, Grill, WM, Walker, HC, Little, SJ, Gilron, R, Tinkhauser, G, Thevathasan, W, Sinclair, NC, Lozano, AM, Foltynie, T, Fasano, A, Sheth, SA, Scangos, K, Sanger, TD, Miller, J, Brumback, AC, Rajasethupathy, P, McIntyre, C, Schlachter, L, Suthana, N, Kubu, C, Sankary, LR, Herrera-Ferra, K, Goetz, S, Cheeran, B, Steinke, GK, Hess, C, Almeida, L, Deeb, W, Foote, KD, Okun, MS, Ramirez-Zamora, A, Giordano, J, Gunduz, A, Alcantara, J, Cagle, JN, Cernera, S, Difuntorum, P, Eisinger, RS, Gomez, J, Long, S, Parks, B, Wong, JK, Chiu, S, Patel, B, Grill, WM, Walker, HC, Little, SJ, Gilron, R, Tinkhauser, G, Thevathasan, W, Sinclair, NC, Lozano, AM, Foltynie, T, Fasano, A, Sheth, SA, Scangos, K, Sanger, TD, Miller, J, Brumback, AC, Rajasethupathy, P, McIntyre, C, Schlachter, L, Suthana, N, Kubu, C, Sankary, LR, Herrera-Ferra, K, Goetz, S, Cheeran, B, Steinke, GK, Hess, C, Almeida, L, Deeb, W, Foote, KD, and Okun, MS
Abstract: The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and utility of complex neurophysiological signals for development of adaptive neurostimulation to improve clinical outcomes; (2) Advancements in recent neuromodulation techniques to treat neuropsychiatric disorders; (3) New developments in optogenetics and DBS; (4) The use of augmented Virtual reality (VR) and neuromodulation; (5) commercially available technologies; and (6) ethical issues arising in and from research and use of DBS. These advances serve as both "markers of progress" and challenges and opportunities for ongoing address, engagement, and deliberation as we move to improve the functional capabilities and translational value of DBS. It is in this light that these proceedings are presented to inform the field and initiate ongoing discourse. As consistent with the intent, and spirit of this, and prior DBS Think Tanks, the overarching goal is to continue to develop multidisciplinary collaborations to rapidly advance the field and ultimately improve patient outcomes.
Published: 2020

8. Global impact of the first coronavirus disease 2019 (COVID-19) pandemic wave on vascular services

Author: Benson, R. A., Sudarsanam, A., Tam, A., Beck, A. W., Barkat, A., Bajwa, A., Elbasty, A., Awopetu, A. I., Kodama, A., Rivera, A. G., Munoz, A., Saltiel, A., Russo, A., Rolls, A., Kafetzakis, A., Kimyaghalam, A., Kordzadeh, A., Shepherd, A., Singh, A., Mingoli, A., Lazaris, A. M., Isaak, A., Marin, A., Valdivia, A. R., Batchelder, A., Duncan, A., Argyriou, A., Jaipersad, A. S., Freyrie, A., Pereira-Neves, A., Mahomed, A., Isik, A., Jawien, A., Choudhry, A. J., Sivaharan, A., Giannoukas, A., Papaioannou, A., Saratzis, A., Abbas, A., Christos, B., Akkaya, B. B., Huasen, B., Patrice, B., Mwipatayi, Azhar, B., Keldiyorov, B., Ullery, B. W., Pratesi, C., Hinojosa, C. A., Bechara, C. F., Parra, C. S., Alexandros, C., Bezard, C., Lee, C. J., Davies, C., Behrendt, C. -A., Lowe, C., Karkos, C. D., Yih, C. L. P., Mcdonnell, C., Ordonez, C., Nesbitt, C., Alexander, C., Guglielmone, D., Doherty, D. T., Riding, D. M., Esposito, D., Harkin, D., Lui, D. H., Kamal, D. M., Telve, D., Theodosiou, D., Angiletta, D., Jacobs, D., Choke, E., Gifford, E. D., Beropoulis, E., Lostoridis, E., Atkins, E., Giacomelli, E., Tsolaki, E., Davies, E., Scott, E., Katsogridakis, E., Serrano, E., Unal, E. U., Lopez, E., Mpaili, E., Minelli, Fabrizio, Malekpour, F., Mousa, F., Meyer, F., Tobar, F., Filipa, J., Johansson, F. G., Weaver, F., Proano, G. A. B., Sidel, G., Kuhan, G., Lemmon, G., Antoniou, G. A., Papadopoulos, G., Pitoulias, G., Sotirios, G., Victoria, G., Frahm-Jensen, G., Tinelli, Giovanni, Asciutto, G., Zenunaj, G., Eduardo, G. V. C., Pullas, G., Oszkinis, G., Popov, G., Iscan, H. Z., Travers, H. C., Barakat, H., Mavioglu, H. L., Chetter, I., Loftus, I., Dodos, I., Asghar, I., Van Herzeele, I., Giordano, J., Cragg, J., Chuen, J., Orrego, J. D. C., Perkins, J., Rocha-Neves, J., Ulloa, J. H., Chavez, J. A., Vidoedo, J., Faraj, J., Mills, J., Varela, J., Ng, J. J., Schmidli, J., Kiriaki, K., Powezka, K., Bowser, K., Darvall, K., Mccune, K., Pasenidou, K., Corless, K., Mckevitt, K., Long, K. N., Moulakakis, K. G., Roditis, K., Stavroulakis, K., Tigkiropoulos, K., Mannoia, K., Abayasekara, K., Jayakumar, L., Wijesinghe, L., Drudi, L., Shelmerdine, L., O'Banion, L. A., Meecham, L., Bennett, L. F., Grillo, L., Green, L., Wales, L., Loureiro, L., Palena, L. M., Tolba, M. M. H., Khashram, M., Chana, M., Pabon, M., Gonzalez, M., Usai, M. V., Tarazona, M., Ruffino, M. A., Castelli, M., Benezit, M., Dias-Neto, M., Malina, M., Maresch, M., Mazzurco, M., Storck, M., Troncoso, M. V., Popplewell, M., Tozzi, M., Metcalfe, M., Laine, M., Rawhi, M., Ricardo, M., Goh, M. A., Ahmed, M. A., Ibrahim, M., Alomari, M., Almudhafer, M., Elhadi, M., Gunawansa, N., Hadjievangelou, N., Hasemaki, N., Shafique, N., Aranson, N., Bradley, N., Mouawad, N. J., Rich, N. C., Floros, N., Patelis, N., Saratzis, N., Tsilimparis, N., Salinas, N., Altaf, N., Friedrich, O., Lyons, O., Mcbride, O. M. B., Ioannidis, O., Falah, O., Theodoridis, P., Sapienza, P., Tsiantoula, P., Chong, P., Coughlin, P., Bevis, P., Carrera, P., Dunlop, P., Wong, P. F., Albino, P., Rossi, P., Nana, P., Stather, P. W., Lapolla, P., Silveira, P. G., Saha, P., Somaiya, P., Pian, P. M., Morley, R. L., Bell, R., Ennab, R. M., Malgor, R., Pulli, R., Makar, R., Sekhar, R., Afifi, R., Coscas, R., Soler, R., Cuff, R. F., Diaz, R., Biagioni, R., Ramely, R. B., Carvajal, R. R., Jhajj, S., Edeiken, S., Benites, S., Zaca, S., Paravastu, S., Chan, S., Sheth, S., Shalhub, S., Dindyal, S., Banegas, S., Hardy, S., Sica, Simona, Tam, S. C., Premnath, S., Renton, S., Rajagopalan, S., Kyriakos, S., Kakkos, S., Ancetti, S., Elkouri, S., Lin, S., Cheng, S. W. K., Koutsias, S. G., Grainger, T., Fekry, T., Tantawy, T. G., Siddiqui, T., Oshodi, T., Akhtar, T., Hardy, T. J., Kotsis, T., Gooneratne, T., Rowlands, T., Cohnert, T. U., Wallace, T., Lane, T. R. A., Bracale, U. M., Cheema, U., Sadia, U., Rubio, V., Canata, V., Jongkind, V., Khetarpaul, V., Summerour, V., Dorigo, W., Al-Jundi, W., Luo, X., Tshomba, Yamume, Serra, Y. G., Minelli F., Tinelli G. (ORCID:0000-0002-2212-3226), Sica S., Tshomba Y. (ORCID:0000-0001-7304-7553), Benson, R. A., Sudarsanam, A., Tam, A., Beck, A. W., Barkat, A., Bajwa, A., Elbasty, A., Awopetu, A. I., Kodama, A., Rivera, A. G., Munoz, A., Saltiel, A., Russo, A., Rolls, A., Kafetzakis, A., Kimyaghalam, A., Kordzadeh, A., Shepherd, A., Singh, A., Mingoli, A., Lazaris, A. M., Isaak, A., Marin, A., Valdivia, A. R., Batchelder, A., Duncan, A., Argyriou, A., Jaipersad, A. S., Freyrie, A., Pereira-Neves, A., Mahomed, A., Isik, A., Jawien, A., Choudhry, A. J., Sivaharan, A., Giannoukas, A., Papaioannou, A., Saratzis, A., Abbas, A., Christos, B., Akkaya, B. B., Huasen, B., Patrice, B., Mwipatayi, Azhar, B., Keldiyorov, B., Ullery, B. W., Pratesi, C., Hinojosa, C. A., Bechara, C. F., Parra, C. S., Alexandros, C., Bezard, C., Lee, C. J., Davies, C., Behrendt, C. -A., Lowe, C., Karkos, C. D., Yih, C. L. P., Mcdonnell, C., Ordonez, C., Nesbitt, C., Alexander, C., Guglielmone, D., Doherty, D. T., Riding, D. M., Esposito, D., Harkin, D., Lui, D. H., Kamal, D. M., Telve, D., Theodosiou, D., Angiletta, D., Jacobs, D., Choke, E., Gifford, E. D., Beropoulis, E., Lostoridis, E., Atkins, E., Giacomelli, E., Tsolaki, E., Davies, E., Scott, E., Katsogridakis, E., Serrano, E., Unal, E. U., Lopez, E., Mpaili, E., Minelli, Fabrizio, Malekpour, F., Mousa, F., Meyer, F., Tobar, F., Filipa, J., Johansson, F. G., Weaver, F., Proano, G. A. B., Sidel, G., Kuhan, G., Lemmon, G., Antoniou, G. A., Papadopoulos, G., Pitoulias, G., Sotirios, G., Victoria, G., Frahm-Jensen, G., Tinelli, Giovanni, Asciutto, G., Zenunaj, G., Eduardo, G. V. C., Pullas, G., Oszkinis, G., Popov, G., Iscan, H. Z., Travers, H. C., Barakat, H., Mavioglu, H. L., Chetter, I., Loftus, I., Dodos, I., Asghar, I., Van Herzeele, I., Giordano, J., Cragg, J., Chuen, J., Orrego, J. D. C., Perkins, J., Rocha-Neves, J., Ulloa, J. H., Chavez, J. A., Vidoedo, J., Faraj, J., Mills, J., Varela, J., Ng, J. J., Schmidli, J., Kiriaki, K., Powezka, K., Bowser, K., Darvall, K., Mccune, K., Pasenidou, K., Corless, K., Mckevitt, K., Long, K. N., Moulakakis, K. G., Roditis, K., Stavroulakis, K., Tigkiropoulos, K., Mannoia, K., Abayasekara, K., Jayakumar, L., Wijesinghe, L., Drudi, L., Shelmerdine, L., O'Banion, L. A., Meecham, L., Bennett, L. F., Grillo, L., Green, L., Wales, L., Loureiro, L., Palena, L. M., Tolba, M. M. H., Khashram, M., Chana, M., Pabon, M., Gonzalez, M., Usai, M. V., Tarazona, M., Ruffino, M. A., Castelli, M., Benezit, M., Dias-Neto, M., Malina, M., Maresch, M., Mazzurco, M., Storck, M., Troncoso, M. V., Popplewell, M., Tozzi, M., Metcalfe, M., Laine, M., Rawhi, M., Ricardo, M., Goh, M. A., Ahmed, M. A., Ibrahim, M., Alomari, M., Almudhafer, M., Elhadi, M., Gunawansa, N., Hadjievangelou, N., Hasemaki, N., Shafique, N., Aranson, N., Bradley, N., Mouawad, N. J., Rich, N. C., Floros, N., Patelis, N., Saratzis, N., Tsilimparis, N., Salinas, N., Altaf, N., Friedrich, O., Lyons, O., Mcbride, O. M. B., Ioannidis, O., Falah, O., Theodoridis, P., Sapienza, P., Tsiantoula, P., Chong, P., Coughlin, P., Bevis, P., Carrera, P., Dunlop, P., Wong, P. F., Albino, P., Rossi, P., Nana, P., Stather, P. W., Lapolla, P., Silveira, P. G., Saha, P., Somaiya, P., Pian, P. M., Morley, R. L., Bell, R., Ennab, R. M., Malgor, R., Pulli, R., Makar, R., Sekhar, R., Afifi, R., Coscas, R., Soler, R., Cuff, R. F., Diaz, R., Biagioni, R., Ramely, R. B., Carvajal, R. R., Jhajj, S., Edeiken, S., Benites, S., Zaca, S., Paravastu, S., Chan, S., Sheth, S., Shalhub, S., Dindyal, S., Banegas, S., Hardy, S., Sica, Simona, Tam, S. C., Premnath, S., Renton, S., Rajagopalan, S., Kyriakos, S., Kakkos, S., Ancetti, S., Elkouri, S., Lin, S., Cheng, S. W. K., Koutsias, S. G., Grainger, T., Fekry, T., Tantawy, T. G., Siddiqui, T., Oshodi, T., Akhtar, T., Hardy, T. J., Kotsis, T., Gooneratne, T., Rowlands, T., Cohnert, T. U., Wallace, T., Lane, T. R. A., Bracale, U. M., Cheema, U., Sadia, U., Rubio, V., Canata, V., Jongkind, V., Khetarpaul, V., Summerour, V., Dorigo, W., Al-Jundi, W., Luo, X., Tshomba, Yamume, Serra, Y. G., Minelli F., Tinelli G. (ORCID:0000-0002-2212-3226), Sica S., and Tshomba Y. (ORCID:0000-0001-7304-7553)
Abstract: This online structured survey has demonstrated the global impact of the COVID-19 pandemic on vascular services. The majority of centres have documented marked reductions in operating and services provided to vascular patients. In the months during recovery from the resource restrictions imposed during the pandemic peaks, there will be a significant vascular disease burden awaiting surgeons. One of the most affected specialties
Published: 2020

9. Reproductive performance of dairy cows resynchronized after pregnancy diagnosis at 31 (±3 days) after artificial insemination (AI) compared with resynchronization at 31 (±3 days) after AI with pregnancy diagnosis at 38 (±3 days) after AI.

Author: Caixeta, L, Caixeta, L, Giordano, J, Guard, C, Bicalho, R, Pereira, Richard, Caixeta, L, Caixeta, L, Giordano, J, Guard, C, Bicalho, R, and Pereira, Richard
Abstract: An important part of reproductive management programs on dairy farms is identification of nonpregnant cows and early re-insemination to achieve higher pregnancy rates. The objective of this study was to compare the effect on reproductive performance and pregnancy loss of 2 pregnancy diagnosis protocols: (1) pregnancy diagnosis performed 31±3 d after artificial insemination (AI) by ultrasonography (ULTRA), and (2) resynchronization started 31±3 d after AI but with pregnancy diagnosis performed 38±3 d after AI by palpation per rectum (PALP). Cows were randomly allocated into 1 of the 2 management programs. For cows enrolled in ULTRA, the initial pregnancy diagnosis (P1) was performed by transrectal ultrasonography at 31±3 d after AI, and nonpregnant cows were enrolled in the Ovsynch protocol for resynchronization of ovulation to receive timed AI (TAI). For cows enrolled in PALP, the Ovsynch protocol for resynchronization of ovulation to receive TAI was initiated at 31±3 d after AI regardless of pregnancy status, with the initial pregnancy diagnosis (P1) performed by palpation per rectum at 38±3 d after AI. For both groups, reconfirmation of pregnancy was performed by palpation per rectum at 63±3 d after AI (P2). Cows were inseminated after detection of estrus by use of activity monitors at any time during the study. Two levels of activity were used as a reference for cows AI after detection of estrus based on activity: an activity level of ≥2 when a cow was coded in DairyComp 305 (Valley Agricultural Software, Tulare, CA) as open (nonpregnant) and an activity level of ≥3 when the pregnancy status of the cow was unknown. Our findings showed that the odds of pregnancy loss cows in ULTRA was 2 times higher between P1 and P2 compared with that of cows in PALP. Furthermore, pregnancy diagnosis method (ULTRA vs. PALP) did not have a significant effect on the Cox proportional hazard of pregnancy at P2. The occurrence of assisted parturition, metritis, or retained placenta wa
Published: 2013

10. The Utility of the BANA Test for Monitoring Anaerobic Infections due to Spirochetes (Treponema denticola) in Periodontal Disease

Author: The University of Michigan School of Dentistry, Ann Arbor, Michigan 48109-1078, Loesche, W. J., Giordano, J., Hujoel, P. P., The University of Michigan School of Dentistry, Ann Arbor, Michigan 48109-1078, Loesche, W. J., Giordano, J., and Hujoel, P. P.
Abstract: Treponema denticola, Porphyromonas gingivalis, and Bacteroides forsythus each possesses an enzyme(s) that hydrolyzes the synthetic substrate benzoyl-DL-arginine-naphthylamide (BANA). The presence of these organisms in a subgingival plaque sample can be determined by the ability of the plaque to hydrolyze BANA. In the present study, we describe the usefulness of the BANA test at various stages of a clinical trial of the efficacy of metronidazole in the treatment of periodontal disease. A BANA-positive test was significantly associated with high levels and proportions of spirochetes in the plaque, so that it provided information comparable with that which could be obtained by a microscopic examination of the plaque. Patients with such anaerobic spirochetal infections were randomly assigned to a group receiving either metronidazole or placebo (250 mg, three times a day) for one week and whose teeth were scaled and root-planed. The advantages of the decision that metronidazole be used were apparent from the comparison with the results obtained in the patients who received only the scaling and root planing. The initially BANA-positive teeth in the patients treated with metronidazole, scaling, and root planing gained attachment and exhibited a significant reduction in the need for periodontal surgery, when compared with the BANA-positive teeth in the patients who received only placebo, scaling, and root planing. After the conclusion of this therapy, those teeth with persistent BANA-positive plaques had significantly higher proportions and levels of spirochetes than did the teeth with BANA-negative plaques. A tooth site which tested BANA-positive after the initial therapy lost significantly more attachment in the year following active treatment than did a tooth site that tested BANA-negative, i.e., a mean difference of 0.48 mm per year. The ability of the BANA test to detect an anaerobic infection due to the BANA-positive species and possibly to predict future attachment l
Published: 2010

11. Magnetization collapse in polycrystalline YBCO under transport current cycles

Author: Giordano, J. L., Luzuriaga, J., Badía-Majós, A., Nieva, G., Ruíz-Tagle, I., Giordano, J. L., Luzuriaga, J., Badía-Majós, A., Nieva, G., and Ruíz-Tagle, I.
Abstract: We report measurements of the hysteretic magnetization of YBCO under superimposed transport current cycles, together with numerical simulations of magnetization and current density profiles in the corresponding parallel configuration. Field cooled (FC) and zero-field-cooled (ZFC) experiments were carried out on polycrystalline YBa2Cu3O7−x cylinders, with both the applied magnetic field and transport current in the axial direction, and the current cycled several times, around and above the dissipative threshold. As in previously reported multicomponent field configuration experiments, the magnetization is seen to collapse to a more stable state both in FC and ZFC, because of the interplay between the shielding and transport currents. The results of our numerical simulations are in good qualitative agreement with the measurements, and the competition between shielding and transport due to vortex-pinning interactions and equilibrium magnetization effects are shown to play an important role in the range of our experiments.
Published: 2006

12. AI (Artificial Intelligence) Gas Turbine Rotor Diagnostics.

Author: MECHANICAL TECHNOLOGY INC LATHAM N Y, Aggarwal,B., Tecza,J., Giordano,J., Brunner,R., MECHANICAL TECHNOLOGY INC LATHAM N Y, Aggarwal,B., Tecza,J., Giordano,J., and Brunner,R.
Abstract: With increased emphasis on improving the reliability and maintainability of gas turbine engines in the U.S. Air Force inventory and the need to operate aircraft from austere forward bases, new diagnostic tools are required. Such tools must provide reliable, consistent diagnoses and minimize training requirements for maintenance personnel. Knowledge-based diagnostic systems have the potential to meet these needs by improving the productivity of USAF maintenance personnel, affecting a standardized diagnostic approach at all maintenance facilities, and providing a wider dissemination of the benefits of accumulated USAF experience in gas turbine vibration diagnostics. Typical rotordynamic faults observed in gas turbine engines were surveyed to assess the extent of knowledge to diagnose rotordynamic faults. A set of generic rotordynamic faults was selected and a diagnostic strategy was developed for those faults. System configuration for a typical knowledge-based rotordynamic diagnostic system was defined based on the requirements identified during the survey. The diagnostic concepts developed were demonstrated using a laboratory test rig capable of having faults implanted in it. Five faults were selected: unbalance, misalignment, rub, increased support flexibility and accessory vibrations. The diagnostic logic for the five faults was implemented as a knowledge-based system (KBS) using the HARVEST fault tree analyzer. The KBS was interfaced to a data acquisition system to acquire vibration data for diagnosis. The integrated system was used successfully to diagnose all faults implanted in the test rig.
Published: 1986

13. Squeeze Film Damper Technology. Part 3. Experimental Investigation of Squeeze Film Dampers.

Author: MECHANICAL TECHNOLOGY INC LATHAM N Y, Walton,J., Pinkus,O., Zorzi,E., Tecza,J., Giordano,J., MECHANICAL TECHNOLOGY INC LATHAM N Y, Walton,J., Pinkus,O., Zorzi,E., Tecza,J., and Giordano,J.
Abstract: A test rig was constructed and proper instrumentation provided for measuring the performance of squeeze film dampers. The tests provided both conceptual understanding of the mechanism of damper operation by providing data on the viscous and inertia components of the fluid film, and on the modalities of oil delivery via the feeding holes and grooves, for both sealed and unsealed dampers. Quantitative data were then provided for the entire gamut of variables attending the design of squeeze film dampers and these were then compared with theoretical predictions. A particularly important part of the test was the visual documentation via both still and motion pictures of cavitation which is still not a fully understood phenomenon under dynamic conditions. Failure tests were conducted to simulate damper response to extreme loadings such as resulting form loss of a turbine blade. While the correlation with theory was shown to be generally valid up to the upper ranges of speeds, the quality of correlation was much affected by the encountered variation of boundary conditions in the feed grooves. The latter thus emerges as an aspect of squeeze film damper mechanics which needs further study.
Published: 1986

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13 results on '"Giordano, J"'

1. The incremental yield of prenatal exome sequencing over chromosome microarray for congenital heart abnormalities:A systematic review and meta-analysis

2. Combining Metacognitive Therapy and tDCS: preliminary results in patients with Major Depressive Disorder

3. Neural plasticity in schizophrenia: an integrated approach for rehabilitation by means of TMS and cognitive remediation training

4. The efficacy of Non-invasive Brain Stimulation techniques on Chronic Primary Pain disorders: a systematic review and meta-analysis

5. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

6. Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial

7. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

8. Global impact of the first coronavirus disease 2019 (COVID-19) pandemic wave on vascular services

9. Reproductive performance of dairy cows resynchronized after pregnancy diagnosis at 31 (±3 days) after artificial insemination (AI) compared with resynchronization at 31 (±3 days) after AI with pregnancy diagnosis at 38 (±3 days) after AI.

10. The Utility of the BANA Test for Monitoring Anaerobic Infections due to Spirochetes (Treponema denticola) in Periodontal Disease

11. Magnetization collapse in polycrystalline YBCO under transport current cycles

12. AI (Artificial Intelligence) Gas Turbine Rotor Diagnostics.

13. Squeeze Film Damper Technology. Part 3. Experimental Investigation of Squeeze Film Dampers.

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