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During the 1970s members of the British Interplanetary Society embarked on a landmark theoretical engineering design study to send a probe to Barnard's star. Project Daedalus was a two-stage vehicle employing electron beam driven inertial confinement fusion engines to reach its target destination. This paper sets out the proposal for a successor interstellar design study called Project Icarus. This is an attempt to redesign the Daedalus vehicle with similar terms of reference. The aim of this study is to evolve an improved engineering design and move us closer to achieving interstellar exploration. Although this paper does not discuss prematurely what design modification are likely to occur some indications are given from the nature of the discussions. This paper is a submission of the Project Icarus Study Group., Comment: 20 pages, 4 figures, 5 tables

We examine the effect of giant planet migration on the formation of inner terrestrial planet systems. We consider situations in which the giant planet halts migration at semi-major axes in the range 0.13 - 1.7 AU due to gas disk dispersal. An N-body code is employed that is linked to a viscous gas disk algorithm capable of simulating: gas loss via accretion onto the central star and photoevaporation; gap formation by the giant planet; type II migration of the giant; optional type I migration of protoplanets; gas drag on planetesimals. We find that most of the inner system planetary building blocks survive the passage of the giant planet, either by being shepherded inward or scattered into exterior orbits. Systems of one or more hot-Earths are predicted to form and remain interior to the giant planet, especially if type II migration has been limited, or where type I migration has affected protoplanetary dynamics. Habitable planets in low eccentricity warm-Jupiter systems appear possible if the giant planet makes a limited incursion into the outer regions of the habitable zone (HZ), or traverses its entire width and ceases migrating at a radial distance of less than half that of the HZ's inner edge. We conclude that Type II migration does not prevent terrestrial planet formation., Comment: Accepted for publication in A&A; 18 pages, 12 figures, 2 tables

We examine the effect of giant planet migration on the formation of inner terrestrial planet systems. We consider situations in which the giant planet halts migration at semi-major axes in the range 0.13 - 1.7 AU due to gas disk dispersal. An N-body code is employed that is linked to a viscous gas disk algorithm capable of simulating: gas loss via accretion onto the central star and photoevaporation; gap formation by the giant planet; type II migration of the giant; optional type I migration of protoplanets; gas drag on planetesimals. We find that most of the inner system planetary building blocks survive the passage of the giant planet, either by being shepherded inward or scattered into exterior orbits. Systems of one or more hot-Earths are predicted to form and remain interior to the giant planet, especially if type II migration has been limited, or where type I migration has affected protoplanetary dynamics. Habitable planets in low eccentricity warm-Jupiter systems appear possible if the giant planet makes a limited incursion into the outer regions of the habitable zone (HZ), or traverses its entire width and ceases migrating at a radial distance of less than half that of the HZ's inner edge. We conclude that Type II migration does not prevent terrestrial planet formation., Comment: Accepted for publication in A&A; 18 pages, 12 figures, 2 tables

The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high-throughput technologies for the efficient structure determination of proteins of biomedical importance, such as those of bacterial and viral pathogens linked to human health. Despite the challenging nature of some of these targets, 175 novel pathogen protein structures (approximately 220 including complexes) have been determined to date. Here the impact of several technologies on the structural determination of proteins from human pathogens is illustrated with selected examples, including the parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens.

The implementation of high- throughput ( HTP) cloning and expression screening in Escherichia coli by 14 laboratories in the Structural Proteomics In Europe ( SPINE) consortium is described. Cloning efficiencies of greater than 80% have been achieved for the three non- ligation- based cloning techniques used, namely Gateway, ligation- indendent cloning of PCR products ( LIC- PCR) and In- Fusion, with LIC- PCR emerging as the most cost- effective. On average, two constructs have been made for each of the approximately 1700 protein targets selected by SPINE for protein production. Overall, HTP expression screening in E. coli has yielded 32% soluble constructs, with at least one for 70% of the targets. In addition to the implementation of HTP cloning and expression screening, the development of two novel technologies is described, namely library- based screening for soluble constructs and parallel small- scale high- density fermentation.