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1,104 results on '"FACCHINI A."'

1. Early skeletal outcomes after hematopoietic stem and progenitor cell gene therapy for Hurler syndrome

Author: Consiglieri, G, Tucci, F, De Pellegrin, M, Guerrini, B, Cattoni, A, Risca, G, Scarparo, S, Sarzana, M, Pontesilli, S, Mellone, R, Gasperini, S, Galimberti, S, Silvani, P, Filisetti, C, Darin, S, Forni, G, Miglietta, S, Santi, L, Facchini, M, Corti, A, Fumagalli, F, Cicalese, M, Calbi, V, Migliavacca, M, Barzaghi, F, Ferrua, F, Gallo, V, Recupero, S, Canarutto, D, Doglio, M, Tedesco, L, Volpi, N, Rovelli, A, la Marca, G, Valsecchi, M, Zancan, S, Ciceri, F, Naldini, L, Baldoli, C, Parini, R, Gentner, B, Aiuti, A, Bernardo, M, Consiglieri, Giulia, Tucci, Francesca, De Pellegrin, Maurizio, Guerrini, Barbara, Cattoni, Alessandro, Risca, Giulia, Scarparo, Stefano, Sarzana, Marina, Pontesilli, Silvia, Mellone, Renata, Gasperini, Serena, Galimberti, Stefania, Silvani, Paolo, Filisetti, Chiara, Darin, Silvia, Forni, Giulia, Miglietta, Simona, Santi, Ludovica, Facchini, Marcella, Corti, Ambra, Fumagalli, Francesca, Cicalese, Maria Pia, Calbi, Valeria, Migliavacca, Maddalena, Barzaghi, Federica, Ferrua, Francesca, Gallo, Vera, Recupero, Salvatore, Canarutto, Daniele, Doglio, Matteo, Tedesco, Lucia, Volpi, Nicola, Rovelli, Attilio, la Marca, Giancarlo, Valsecchi, Maria Grazia, Zancan, Stefano, Ciceri, Fabio, Naldini, Luigi, Baldoli, Cristina, Parini, Rossella, Gentner, Bernhard, Aiuti, Alessandro, Bernardo, Maria Ester, Consiglieri, G, Tucci, F, De Pellegrin, M, Guerrini, B, Cattoni, A, Risca, G, Scarparo, S, Sarzana, M, Pontesilli, S, Mellone, R, Gasperini, S, Galimberti, S, Silvani, P, Filisetti, C, Darin, S, Forni, G, Miglietta, S, Santi, L, Facchini, M, Corti, A, Fumagalli, F, Cicalese, M, Calbi, V, Migliavacca, M, Barzaghi, F, Ferrua, F, Gallo, V, Recupero, S, Canarutto, D, Doglio, M, Tedesco, L, Volpi, N, Rovelli, A, la Marca, G, Valsecchi, M, Zancan, S, Ciceri, F, Naldini, L, Baldoli, C, Parini, R, Gentner, B, Aiuti, A, Bernardo, M, Consiglieri, Giulia, Tucci, Francesca, De Pellegrin, Maurizio, Guerrini, Barbara, Cattoni, Alessandro, Risca, Giulia, Scarparo, Stefano, Sarzana, Marina, Pontesilli, Silvia, Mellone, Renata, Gasperini, Serena, Galimberti, Stefania, Silvani, Paolo, Filisetti, Chiara, Darin, Silvia, Forni, Giulia, Miglietta, Simona, Santi, Ludovica, Facchini, Marcella, Corti, Ambra, Fumagalli, Francesca, Cicalese, Maria Pia, Calbi, Valeria, Migliavacca, Maddalena, Barzaghi, Federica, Ferrua, Francesca, Gallo, Vera, Recupero, Salvatore, Canarutto, Daniele, Doglio, Matteo, Tedesco, Lucia, Volpi, Nicola, Rovelli, Attilio, la Marca, Giancarlo, Valsecchi, Maria Grazia, Zancan, Stefano, Ciceri, Fabio, Naldini, Luigi, Baldoli, Cristina, Parini, Rossella, Gentner, Bernhard, Aiuti, Alessandro, and Bernardo, Maria Ester
Abstract: Mucopolysaccharidosis type I Hurler (MPSIH) is characterized by severe and progressive skeletal dysplasia that is not fully addressed by allogeneic hematopoietic stem cell transplantation (HSCT). Autologous hematopoietic stem progenitor cell-gene therapy (HSPC-GT) provides superior metabolic correction in patients with MPSIH compared with HSCT; however, its ability to affect skeletal manifestations is unknown. Eight patients with MPSIH (mean age at treatment: 1.9 years) received lentiviral-based HSPC-GT in a phase 1/2 clinical trial (NCT03488394). Clinical (growth, measures of kyphosis and genu velgum), functional (motor function, joint range of motion), and radiological [acetabular index (AI), migration percentage (MP) in hip x-rays and MRIs and spine MRI score] parameters of skeletal dysplasia were evaluated at baseline and multiple time points up to 4 years after treatment. Specific skeletal measures were retrospectively compared with an external cohort of HSCT-treated patients. At a median follow-up of 3.78 years after HSPC-GT, all patients treated with HSPC-GT exhibited longitudinal growth within WHO reference ranges and a median height gain greater than that observed in patients treated with HSCT after 3-year follow-up. Patients receiving HSPC-GT experienced complete and earlier normalization of joint mobility compared with patients treated with HSCT. Mean AI and MP showed progressive decreases after HSPC-GT, suggesting a reduction in acetabular dysplasia. Typical spine alterations measured through a spine MRI score stabilized after HSPC-GT. Clinical, functional, and radiological measures suggested an early beneficial effect of HSPC-GT on MPSIH-typical skeletal features. Longer follow-up is needed to draw definitive conclusions on HSPC-GT's impact on MPSIH skeletal dysplasia.
Published: 2024

2. The Swedish Model as a way to the full development of nations. A game, some history and some empirical evidence

Author: Facchini, Davide and Facchini, Davide
Published: 2024

3. The SPHERE view of the Taurus star-forming region : The full census of planet-forming disks with GTO and DESTINYS programs

Author: Garufi, A., Ginski, C., van Holstein, R. G., Benisty, M., Manara, C. F., Pérez, S., Pinilla, P., Ribas, Á., Weber, P., Williams, J., Cieza, L., Dominik, C., Facchini, S., Huang, J., Zurlo, A., Bae, J., Hagelberg, J., Henning, Th., Hogerheijde, M. R., Janson, Markus, Ménard, F., Messina, S., Meyer, M. R., Pinte, C., Quanz, S. P., Rigliaco, E., Roccatagliata, V., Schmid, H. M., Szulágyi, J., van Boekel, R., Wahhaj, Z., Antichi, J., Baruffolo, A., Moulin, T., Garufi, A., Ginski, C., van Holstein, R. G., Benisty, M., Manara, C. F., Pérez, S., Pinilla, P., Ribas, Á., Weber, P., Williams, J., Cieza, L., Dominik, C., Facchini, S., Huang, J., Zurlo, A., Bae, J., Hagelberg, J., Henning, Th., Hogerheijde, M. R., Janson, Markus, Ménard, F., Messina, S., Meyer, M. R., Pinte, C., Quanz, S. P., Rigliaco, E., Roccatagliata, V., Schmid, H. M., Szulágyi, J., van Boekel, R., Wahhaj, Z., Antichi, J., Baruffolo, A., and Moulin, T.
Abstract: The sample of planet-forming disks observed by high-contrast imaging campaigns over the last decade is mature enough to enable the demographical analysis of individual star-forming regions. We present the full census of Taurus sources with VLT/SPHERE polarimetric images available. The whole sample sums up to 43 targets (of which 31 have not been previously published) corresponding to one-fifth of the Class II population in Taurus and about half of such objects that are observable. A large fraction of the sample is apparently made up of isolated faint disks (equally divided between small and large self-shadowed disks). Ambient signal is visible in about one-third of the sample. This probes the interaction with the environment and with companions or the outflow activity of the system. The central portion of the Taurus region almost exclusively hosts faint disks, while the periphery also hosts bright disks interacting with their surroundings. The few bright disks are found around apparently older stars. The overall picture is that the Taurus region is in an early evolutionary stage of planet formation. Yet, some objects are discussed individually, as in an intermediate or exceptional stage of the disk evolution. This census provides a first benchmark for the comparison of the disk populations in different star forming regions.
Published: 2024
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4. A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

Author: Cortese, A, Beecroft, SJ, Facchini, S, Curro, R, Cabrera-Serrano, M, Stevanovski, I, Chintalaphani, SR, Gamaarachchi, H, Weisburd, B, Folland, C, Monahan, G, Scriba, CK, Dofash, L, Johari, M, Grosz, BR, Ellis, M, Fearnley, LG, Tankard, R, Read, J, Merve, A, Dominik, N, Vegezzi, E, Schnekenberg, RP, Fernandez-Eulate, G, Masingue, M, Giovannini, D, Delatycki, MB, Storey, E, Gardner, M, Amor, DJ, Nicholson, G, Vucic, S, Henderson, RD, Robertson, T, Dyke, J, Fabian, V, Mastaglia, F, Davis, MR, Kennerson, M, Quinlivan, R, Hammans, S, Tucci, A, Bahlo, M, McLean, CA, Laing, NG, Stojkovic, T, Houlden, H, Hanna, MG, Deveson, IW, Lockhart, PJ, Lamont, PJ, Fahey, MC, Bugiardini, E, Ravenscroft, G, Oflazer, P, Basak, NA, Kayserili, H, Yesil, G, Malfatti, E, Lilliker, JB, Wicklund, M, Pitceathly, RDS, Brady, S, Brais, B, Pellerin, D, Zuchner, S, Danzi, MC, Grandis, M, Comi, GP, Corti, SP, Abati, E, Toscano, A, Manini, A, Ghia, A, Tassorelli, C, Quartesan, I, Simone, R, Rossor, AM, Reilly, MM, Carroll, L, Straub, V, Udd, B, Chen, Z, Bonne, G, Cortese, A, Beecroft, SJ, Facchini, S, Curro, R, Cabrera-Serrano, M, Stevanovski, I, Chintalaphani, SR, Gamaarachchi, H, Weisburd, B, Folland, C, Monahan, G, Scriba, CK, Dofash, L, Johari, M, Grosz, BR, Ellis, M, Fearnley, LG, Tankard, R, Read, J, Merve, A, Dominik, N, Vegezzi, E, Schnekenberg, RP, Fernandez-Eulate, G, Masingue, M, Giovannini, D, Delatycki, MB, Storey, E, Gardner, M, Amor, DJ, Nicholson, G, Vucic, S, Henderson, RD, Robertson, T, Dyke, J, Fabian, V, Mastaglia, F, Davis, MR, Kennerson, M, Quinlivan, R, Hammans, S, Tucci, A, Bahlo, M, McLean, CA, Laing, NG, Stojkovic, T, Houlden, H, Hanna, MG, Deveson, IW, Lockhart, PJ, Lamont, PJ, Fahey, MC, Bugiardini, E, Ravenscroft, G, Oflazer, P, Basak, NA, Kayserili, H, Yesil, G, Malfatti, E, Lilliker, JB, Wicklund, M, Pitceathly, RDS, Brady, S, Brais, B, Pellerin, D, Zuchner, S, Danzi, MC, Grandis, M, Comi, GP, Corti, SP, Abati, E, Toscano, A, Manini, A, Ghia, A, Tassorelli, C, Quartesan, I, Simone, R, Rossor, AM, Reilly, MM, Carroll, L, Straub, V, Udd, B, Chen, Z, and Bonne, G
Abstract: Oculopharyngodistal myopathy (OPDM) is an inherited myopathy manifesting with ptosis, dysphagia and distal weakness. Pathologically it is characterised by rimmed vacuoles and intranuclear inclusions on muscle biopsy. In recent years CGG • CCG repeat expansion in four different genes were identified in OPDM individuals in Asian populations. None of these have been found in affected individuals of non-Asian ancestry. In this study we describe the identification of CCG expansions in ABCD3, ranging from 118 to 694 repeats, in 35 affected individuals across eight unrelated OPDM families of European ancestry. ABCD3 transcript appears upregulated in fibroblasts and skeletal muscle from OPDM individuals, suggesting a potential role of over-expression of CCG repeat containing ABCD3 transcript in progressive skeletal muscle degeneration. The study provides further evidence of the role of non-coding repeat expansions in unsolved neuromuscular diseases and strengthens the association between the CGG • CCG repeat motif and a specific pattern of muscle weakness.
Published: 2024

5. L’Iter Gallicum come opera storica

Author: Saraceno, Lorenzo, D'Acunto, Nicolangelo, Facchini, Ugo, Manco, Antonio, manco (ORCID:0000-0002-0794-8692), Saraceno, Lorenzo, D'Acunto, Nicolangelo, Facchini, Ugo, Manco, Antonio, and manco (ORCID:0000-0002-0794-8692)
Abstract: La prima traduzione edita dell'Iter Gallicum, opera composta da un anonimo discepolo di Pier Damiani e compagno di viaggio nel corso della missione in Gallia. Qui Pier Damiani è ospite dei monaci cluniacensi e si adopera in prima persona per risolvere le controversie tra Cluny e il vescovo di Macon. Un'introduzione analizza non solo la tradizione manoscritta e le controversie sull'anomimo autore, ma analizza anche la figura dell'eremita di Fonte Avellana che traspare dall'opera.
Published: 2024

6. Security or Human Rights? An analysis of the Cannabis legalization process in Uruguay

Author: Facchini da Silva, Allana, Moreira de Souza Rodrigues, Thiago, Facchini da Silva, Allana, and Moreira de Souza Rodrigues, Thiago
Abstract: Considering the Cannabis legalization process in Uruguay, we worked on the hypothesisthat the country’s strategy was based on a security logic, in contrast to global pro-cannabisdiscourses. Using qualitative analysis techniques and the theoretical-methodological frameworkof the Drug Policy Framework, we concluded that the appeal to the security logic was theway to change the legal status of cannabis, because, in the dimension of moral values, thedefense of human rights would not mobilize legal transformations. The main contradictionin this process is that historically and internationally, security arguments underpin drugprohibition and its repressive policies., Considerando el proceso de legalización del Cannabis en Uruguay, trabajamos sobre lahipótesis de que la estrategia del país se basó en una lógica de seguridad, en contrastecon los discursos globales pro-cannabis. Utilizando técnicas de análisis cualitativo y elmarco teórico-metodológico del Drug Policy Framework, concluimos que la apelación ala lógica de seguridad fue el camino para cambiar el status legal del cannabis, porque, enla dimensión de los valores morales, la defensa de los derechos humanos no movilizaríatransformaciones legales. La principal contradicción de este proceso es que, histórica einternacionalmente, los argumentos de seguridad sustentan la prohibición de las drogasy sus políticas represivas., Considerando o processo de legalização da Cannabis no Uruguai, trabalhamos a hipótese de que a estratégia operada pelo país se fundamentou numa lógica securitária, em contraste com os discursos pró-canábicos globais. Utilizando-nos de técnicas de análises qualitativas e do marco teórico-metodológico do Drug Policy Framework, concluímos que o apelo à lógica securitária foi a via para alterar o status jurídico da Cannabis, pois, na dimensão dos valores morais, a defesa dos direitos humanos não mobilizaria transformações legais. A principal contradição deste processo é que os argumentos securitários, histórica e internacionalmente, fundamentam a proibição das drogas e suas políticas repressivas.
Published: 2024

7. Educational tracking and social inequalities in long-term labor market outcomes:Six countries in comparison

Author: Schindler, Steffen, Bar-Haim, Yair, Barone, Carlo, Birkelund, Jesper Fels, Boliver, Vikki, Capsada-Munsech, Queralt, Erola, Jani, Facchini, Marta, Feniger, Yariv, Heiskala, Laura, Herbaut, Estelle, Ichou, ‪Mathieu, Karlson, Kristian Bernt, Kleinert, Corina, Reimer, David, Traini, Claudia, Triventi, Moris, Vallet, Louis-André, Schindler, Steffen, Bar-Haim, Yair, Barone, Carlo, Birkelund, Jesper Fels, Boliver, Vikki, Capsada-Munsech, Queralt, Erola, Jani, Facchini, Marta, Feniger, Yariv, Heiskala, Laura, Herbaut, Estelle, Ichou, ‪Mathieu, Karlson, Kristian Bernt, Kleinert, Corina, Reimer, David, Traini, Claudia, Triventi, Moris, and Vallet, Louis-André
Abstract: In this country-comparative study, we ask to what extent differentiation in secondary education accounts for the association between social origins and social destinations in adult age. We go beyond the widely applied formal definitions of educational tracking and particularly pay attention to country-specific approaches to educational differentiation. Our main expectation is that once we factor in these particularities, the degree to which educational differentiation accounts for social reproduction is quite similar across countries. Our analyses are based on national individual-level life-course data from six European countries that span from secondary education to occupational maturity. Our findings show that educational differentiation mediates the association between social origins and social destinations to a substantial degree in all countries. However, we still find some differences between countries in the extent to which educational differentiation accounts for social reproduction.
Published: 2024

8. Kaleidoscope of irradiated disks: MUSE observations of proplyds in the Orion Nebula Cluster. I. Sample presentation and ionization front sizes

Author: Aru, Mari-Liis, Mauco, Karina, Manara, Carlo F., Haworth, Thomas J., Facchini, Stefano, McLeod, Anna F., Miotello, Anna, Petr-Gotzens, Monika G., Robberto, Massimo, Rosotti, Giovanni P., Vicente, Silvia, Winter, Andrew, Ansdell, Megan, Aru, Mari-Liis, Mauco, Karina, Manara, Carlo F., Haworth, Thomas J., Facchini, Stefano, McLeod, Anna F., Miotello, Anna, Petr-Gotzens, Monika G., Robberto, Massimo, Rosotti, Giovanni P., Vicente, Silvia, Winter, Andrew, and Ansdell, Megan
Abstract: In the Orion Nebula Cluster (ONC), protoplanetary disks exhibit ionized gas clouds in the form of a striking teardrop shape as massive stars irradiate the disk material. We present the first spatially and spectrally resolved observations of 12 proplyds, using Integral Field Spectroscopy observations performed with the MUSE instrument in Narrow Field Mode (NFM) on the VLT. We present the morphology of the proplyds in seven emission lines and measure the radius of the ionization front (I-front) of the targets in four tracers, covering transitions of different ionization states for the same element. We also derive stellar masses for the targets. The measurements follow a consistent trend of increasing I-front radius for a decreasing strength of the far-UV radiation as expected from photoevaporation models. By analyzing the ratios of the I-front radii as measured in the emission lines of Ha, [OI] 6300, [OII] 7330, and [OIII] 5007, we observe the ionization stratification, that is, the most ionized part of the flow being the furthest from the disk (and closest to the UV source). The ratios of I-front radii scale in the same way for all proplyds in our sample regardless of the incident radiation. We show that the stratification can help constrain the densities near the I-front by using a 1D photoionization model. We derive the upper limits of photoevaporative mass-loss rates by assuming ionization equilibrium, and estimate values decreasing towards lower impinging radiation. We do not find a correlation between Mloss and stellar mass. The highest mass-loss rate is for the proplyd 244-440. These values of Mloss, combined with estimates of the disk mass with ALMA, confirm previous estimates of the short lifetime of these proplyds. This work demonstrates the potential of this dataset and offers a new set of observables to be used to test current and future models of external photoevaporation., Comment: Submitted to A&A on December 18, 2023. Accepted on April 2, 2024
Published: 2024

9. Survival of the long-lived inner disk of PDS 70

Author: Pinilla, Paola, Benisty, Myriam, Waters, Rens, Bae, Jaehan, Facchini, Stefano, Pinilla, Paola, Benisty, Myriam, Waters, Rens, Bae, Jaehan, and Facchini, Stefano
Abstract: The K7 T Tauri star PDS 70 remains the best laboratory for investigating the influence of giant planet formation on the structure of the parental disk. One of the most intriguing discoveries is the detection of a resolved inner disk from ALMA observations that extends up to the orbit of PDS 70b. It is challenging to explain this inner disk because most of the dust particles are expected to be trapped at the outer edge of the gap opened by PDS 70b and PDS 70c. By performing dust evolution models in combination with radiative transfer simulations that match the gas disk masses obtained from recent thermo-chemical models of PDS 70, we find that when the minimum grain size in the models is larger than 0.1$\mu$m, there is an efficient filtration of dust particles, and the inner disk is depleted during the first million year of dust evolution. To maintain an inner disk, the minimum grain size in the models therefore needs to be smaller than 0.1$\mu$m. Only when grains are that small are they diffused and dragged along with the gas throughout the gap opened by the planets. The small grains transported in the inner disk grow and drift into it, but the constant reservoir of dust particles that are trapped at the outer edge of the gap and that continuously fragment allows the inner disk to refill on million-year timescales. Our flux predictions at millimeter wavelength of these models agree with ALMA observations. These models predict a spectral index of 3.2 in the outer and 3.6 in the inner disk. Our simple analytical calculations show that the water emission in the inner disk that was recently observed with the James Webb Space Telescope may originate from these ice-coated small grains that flow through the gap, grow, and drift toward the innermost disk regions to reach the water snowline., Comment: Accepted for publication in A&A. Final version after language edition
Published: 2024

10. The SPHERE view of the Chamaeleon I star-forming region

Author: Ginski, C., Garufi, A., Benisty, M., Tazaki, R., Dominik, C., Ribas, A., Engler, N., Birnstiel, T., Chauvin, G., Columba, G., Facchini, S., Goncharov, A., Hagelberg, J., Henning, T., Hogerheijde, M., van Holstein, R. G., Huang, J., Muto, T., Pinilla, P., Kanagawa, K., Kim, S., Kurtovic, N., Langlois, M., Manara, C., Milli, J., Momose, M., Orihara, R., Pawellek, N., Pinte, C., Rab, C., Schmidt, T. O. B., Snik, F., Wahhaj, Z., Williams, J., Zurlo, A., Ginski, C., Garufi, A., Benisty, M., Tazaki, R., Dominik, C., Ribas, A., Engler, N., Birnstiel, T., Chauvin, G., Columba, G., Facchini, S., Goncharov, A., Hagelberg, J., Henning, T., Hogerheijde, M., van Holstein, R. G., Huang, J., Muto, T., Pinilla, P., Kanagawa, K., Kim, S., Kurtovic, N., Langlois, M., Manara, C., Milli, J., Momose, M., Orihara, R., Pawellek, N., Pinte, C., Rab, C., Schmidt, T. O. B., Snik, F., Wahhaj, Z., Williams, J., and Zurlo, A.
Abstract: We used VLT/SPHERE to observe 20 systems in the Cha I cloud in polarized scattered light in the near-infrared. We combined the scattered light observations with existing literature data on stellar properties and with archival ALMA continuum data to study trends with system age and dust mass. We also connected resolved near-infrared observations with the spectral energy distributions of the systems. In 13 of the 20 systems included in this study we detected resolved scattered light signals from circumstellar dust. For the CR Cha, CT Cha, CV Cha, SY Cha, SZ Cha, and VZ Cha systems we present the first detailed descriptions of the disks in scattered light. The observations found typically smooth or faint disks, often with little substructure, with the notable exceptions of SZ Cha, which shows an extended multiple-ringed disk, and WW Cha, which shows interaction with the cloud environment. New high S/N K- band observations of the HD 97048 system in our survey reveal a significant brightness asymmetry that may point to disk misalignment and subsequent shadowing of outer disk regions, possibly related to the suggested planet candidate in the disk. We resolve for the first time the stellar binary in the CS Cha system. Multiple wavelength observations of the disk around CS Cha have revealed that the system contains small, compact dust grains that may be strongly settled, consistent with numerical studies of circumbinary disks. We find in our sample that there is a strong anti-correlation between the presence of a (close) stellar companion and the detection of circumstellar material with five of our seven nondetections located in binary systems., Comment: Accepted by A&A
Published: 2024

11. The SPHERE view of the Taurus star-forming region

Author: Garufi, A., Ginski, C., van Holstein, R. G., Benisty, M., Manara, C. F., Pérez, S., Pinilla, P., Ribas, Á., Weber, P., Williams, J., Cieza, L., Dominik, C., Facchini, S., Huang, J., Zurlo, A., Bae, J., Hagelberg, J., Henning, Th., Hogerheijde, M. R., Janson, M., Ménard, F., Messina, S., Meyer, M. R., Pinte, C., Quanz, S. P., Rigliaco, E., Roccatagliata, V., Schmid, H. M., Szulágyi, J., van Boekel, R., Wahhaj, Z., Antichi, J., Baruffolo, A., Moulin, T., Garufi, A., Ginski, C., van Holstein, R. G., Benisty, M., Manara, C. F., Pérez, S., Pinilla, P., Ribas, Á., Weber, P., Williams, J., Cieza, L., Dominik, C., Facchini, S., Huang, J., Zurlo, A., Bae, J., Hagelberg, J., Henning, Th., Hogerheijde, M. R., Janson, M., Ménard, F., Messina, S., Meyer, M. R., Pinte, C., Quanz, S. P., Rigliaco, E., Roccatagliata, V., Schmid, H. M., Szulágyi, J., van Boekel, R., Wahhaj, Z., Antichi, J., Baruffolo, A., and Moulin, T.
Abstract: The sample of planet-forming disks observed by high-contrast imaging campaigns over the last decade is mature enough to enable the demographical analysis of individual star-forming regions. We present the full census of Taurus sources with VLT/SPHERE polarimetric images available. The whole sample sums up to 43 targets (of which 31 have not been previously published) corresponding to one-fifth of the Class II population in Taurus and about half of such objects that are observable. A large fraction of the sample is apparently made up of isolated faint disks (equally divided between small and large self-shadowed disks). Ambient signal is visible in about one-third of the sample. This probes the interaction with the environment and with companions or the outflow activity of the system. The central portion of the Taurus region almost exclusively hosts faint disks, while the periphery also hosts bright disks interacting with their surroundings. The few bright disks are found around apparently older stars. The overall picture is that the Taurus region is in an early evolutionary stage of planet formation. Yet, some objects are discussed individually, as in an intermediate or exceptional stage of the disk evolution. This census provides a first benchmark for the comparison of the disk populations in different star forming regions., Comment: Accepted by A&A
Published: 2024

12. The SPHERE view of the Orion star-forming region

Author: Valegard, P. -G., Ginski, C., Derkink, A., Garufi, A., Dominik, C., Ribas, A., Williams, J. P., Benisty, M., Birnstiel, T., Facchini, S., Columba, G., Hogerheijde, M., Van Holstein, R. G., Huang, J., Kenworthy, M., Manara, C. F., Pinilla, P., Rab, Ch., Sulaiman, R., Zurlo, A., Valegard, P. -G., Ginski, C., Derkink, A., Garufi, A., Dominik, C., Ribas, A., Williams, J. P., Benisty, M., Birnstiel, T., Facchini, S., Columba, G., Hogerheijde, M., Van Holstein, R. G., Huang, J., Kenworthy, M., Manara, C. F., Pinilla, P., Rab, Ch., Sulaiman, R., and Zurlo, A.
Abstract: We present SPHERE/IRDIS H-band data for a sample of 23 stars in the Orion Star forming region observed within the DESTINYS (Disk Evolution Study Through Imaging of Nearby Young Stars) program. We use polarization differential imaging in order to detect scattered light from circumstellar dust. From the scattered light observations we characterize the disk orientation, radius and contrast. We analyse the disks in context of the stellar parameters and the environment of the Orion star-forming region. We use ancillary X-shooter spectroscopic observations to characterize the central stars in the systems. We furthermore use a combination of new and archival ALMA mm-continuum observations to characterize the dust masses present in the circumstellar disks. Within our sample we detect extended circumstellar disks in 10 of 23 systems. Of these, three are exceptionally extended (V351 Ori, V599 Ori and V1012 Ori) and show scattered light asymmetries which may indicate perturbations by embedded planets or (in the case of V599 Ori) by an outer stellar companion. Our high resolution imaging observations are also sensitive to close (sub)stellar companions and we detect 9 such objects in our sample of which 5 were previously unknown. We find in particular a possible sub-stellar companion (either a very low mass star or a high mass brown dwarf) 137 au from the star RY Ori. We find a strong anti-correlation between disk detection and multiplicity, with only 2 of our 10 disk detections located in stellar multiple systems. We also find a correlation between scattered light contrast and the millimetre flux suggesting that disks that have a high dust content are typically bright in near-infrared scattered light. Conversely we do not find significant correlations between scattered light contrast of the disks and the stellar mass or age., Comment: Accepted by A&A
Published: 2024

13. Resolved ALMA observations of water in the inner astronomical units of the HL Tau disk

Author: Facchini, Stefano, Testi, Leonardo, Humphreys, Elizabeth, Donckt, Mathieu Vander, Isella, Andrea, Wrzosek, Ramon, Baudry, Alain, Gray, Malcom D., Richards, Anita M. S., Vlemmmings, Wouter, Facchini, Stefano, Testi, Leonardo, Humphreys, Elizabeth, Donckt, Mathieu Vander, Isella, Andrea, Wrzosek, Ramon, Baudry, Alain, Gray, Malcom D., Richards, Anita M. S., and Vlemmmings, Wouter
Abstract: The water molecule is a key ingredient in the formation of planetary systems, with the water snowline being a favourable location for the growth of massive planetary cores. Here we present Atacama Large Millimeter/ submillimeter Array data of the ringed protoplanetary disk orbiting the young star HL Tauri that show centrally peaked, bright emission arising from three distinct transitions of the main water isotopologue. The spatially and spectrally resolved water content probes gas in a thermal range down to the water sublimation temperature. Our analysis implies a stringent lower limit of 3.7 Earth oceans of water vapour available within the inner 17 astronomical units of the system. We show that our observations are limited to probing the water content in the atmosphere of the disk, due to the high dust column density and absorption, and indicate that the main water isotopologue is the best tracer to spatially resolve water vapour in protoplanetary disks., Comment: Published in Nature Astronomy (2024), arXiv version presents text and figures before proofing
Published: 2024
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14. Rotation curves in protoplanetary disks with thermal stratification

Author: Martire, Paola, Longarini, Cristiano, Lodato, Giuseppe, Rosotti, Giovanni P., Winter, Andrew, Facchini, Stefano, Hardiman, Caitlyn, Benisty, Myriam, Stadler, Jochen, Izquierdo, Andrés F., Testi, Leonardo, Martire, Paola, Longarini, Cristiano, Lodato, Giuseppe, Rosotti, Giovanni P., Winter, Andrew, Facchini, Stefano, Hardiman, Caitlyn, Benisty, Myriam, Stadler, Jochen, Izquierdo, Andrés F., and Testi, Leonardo
Abstract: In recent years the gas kinematics probed by molecular lines detected with ALMA has opened a new window to study protoplanetary disks. High spatial and spectral resolution observations have revealed the complexity of protoplanetary disk structure and correctly interpreting these data allow us to gain a better comprehension of the planet formation process. We investigate the impact of thermal stratification on the azimuthal velocity of protoplanetary disks. High resolution gas observations are showing velocity differences between CO isotopologues, which cannot be adequately explained with vertically isothermal models. The aim of this work is to determine whether a stratified model can explain this discrepancy. We analytically solve the hydrostatic equilibrium for a stratified disk and we derive the azimuthal velocity. We test the model with SPH numerical simulations and then we use it to fit for star mass, disk mass and scale radius of the sources in the MAPS sample. In particular, we use 12CO and 13CO datacubes., Comment: 16 pages, 12 figures, accepted for publication on A&A
Published: 2024

15. Mapping the Vertical Gas Structure of the Planet-hosting PDS 70 Disk

Author: Law, Charles J., Benisty, Myriam, Facchini, Stefano, Teague, Richard, Bae, Jaehan, Isella, Andrea, Kamp, Inga, Öberg, Karin I., Portilla-Revelo, Bayron, Rampinelli, Luna, Law, Charles J., Benisty, Myriam, Facchini, Stefano, Teague, Richard, Bae, Jaehan, Isella, Andrea, Kamp, Inga, Öberg, Karin I., Portilla-Revelo, Bayron, and Rampinelli, Luna
Abstract: PDS 70 hosts two massive, still-accreting planets and the inclined orientation of its protoplanetary disk presents a unique opportunity to directly probe the vertical gas structure of a planet-hosting disk. Here, we use high-spatial-resolution (${\approx}$0."1;10 au) observations in a set of CO isotopologue lines and HCO$^+$ J=4-3 to map the full 2D $(r,z)$ disk structure from the disk atmosphere, as traced by $^{12}$CO, to closer to the midplane, as probed by less abundant isotopologues and HCO$^+$. In the PDS 70 disk, $^{12}$CO traces a height of $z/r\approx0.3$, $^{13}$CO is found at $z/r\approx0.1$, and C$^{18}$O originates at, or near, the midplane. The HCO$^+$ surface arises from $z/r\approx0.2$ and is one of the few non-CO emission surfaces constrained with high fidelity in disks to date. In the $^{12}$CO J=3-2 line, we resolve a vertical dip and steep rise in height at the cavity wall, making PDS 70 the first transition disk where this effect is directly seen in line emitting heights. In the outer disk, the CO emission heights of PDS 70 appear typical for its stellar mass and disk size and are not substantially altered by the two inner embedded planets. By combining CO isotopologue and HCO$^+$ lines, we derive the 2D gas temperature structure and estimate a midplane CO snowline of ${\approx}$56-85 au. This implies that both PDS 70b and 70c are located interior to the CO snowline and are likely accreting gas with a high C/O ratio of ${\approx}$1.0, which provides context for future planetary atmospheric measurements from, e.g., JWST, and for properly modeling their formation histories., Comment: 24 pages, 14 figures, accepted for publication in ApJ
Published: 2024

16. Addressing Social Misattributions of Large Language Models: An HCXAI-based Approach

Author: Ferrario, Andrea, Termine, Alberto, Facchini, Alessandro, Ferrario, Andrea, Termine, Alberto, and Facchini, Alessandro
Abstract: Human-centered explainable AI (HCXAI) advocates for the integration of social aspects into AI explanations. Central to the HCXAI discourse is the Social Transparency (ST) framework, which aims to make the socio-organizational context of AI systems accessible to their users. In this work, we suggest extending the ST framework to address the risks of social misattributions in Large Language Models (LLMs), particularly in sensitive areas like mental health. In fact LLMs, which are remarkably capable of simulating roles and personas, may lead to mismatches between designers' intentions and users' perceptions of social attributes, risking to promote emotional manipulation and dangerous behaviors, cases of epistemic injustice, and unwarranted trust. To address these issues, we propose enhancing the ST framework with a fifth 'W-question' to clarify the specific social attributions assigned to LLMs by its designers and users. This addition aims to bridge the gap between LLM capabilities and user perceptions, promoting the ethically responsible development and use of LLM-based technology., Comment: Extended version of the manuscript accepted for the ACM CHI Workshop on Human-Centered Explainable AI 2024 (HCXAI24)
Published: 2024

17. Designing for Complementarity: A Conceptual Framework to Go Beyond the Current Paradigm of Using XAI in Healthcare

Author: Rubegni, Elisa, Ayoub, Omran, Rizzo, Stefania Maria Rita, Barbero, Marco, Bernegger, Guenda, Faraci, Francesca, Mangili, Francesca, Soldini, Emiliano, Trimboli, Pierpaolo, Facchini, Alessandro, Rubegni, Elisa, Ayoub, Omran, Rizzo, Stefania Maria Rita, Barbero, Marco, Bernegger, Guenda, Faraci, Francesca, Mangili, Francesca, Soldini, Emiliano, Trimboli, Pierpaolo, and Facchini, Alessandro
Abstract: The widespread use of Artificial Intelligence-based tools in the healthcare sector raises many ethical and legal problems, one of the main reasons being their black-box nature and therefore the seemingly opacity and inscrutability of their characteristics and decision-making process. Literature extensively discusses how this can lead to phenomena of over-reliance and under-reliance, ultimately limiting the adoption of AI. We addressed these issues by building a theoretical framework based on three concepts: Feature Importance, Counterexample Explanations, and Similar-Case Explanations. Grounded in the literature, the model was deployed within a case study in which, using a participatory design approach, we designed and developed a high-fidelity prototype. Through the co-design and development of the prototype and the underlying model, we advanced the knowledge on how to design AI-based systems for enabling complementarity in the decision-making process in the healthcare domain. Our work aims at contributing to the current discourse on designing AI systems to support clinicians' decision-making processes.
Published: 2024

18. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author: Tài, Pham, Leo, Heunk, Giacomo, Bellani, Fabiana, Madotto, Irene, Aragao, Gaëtan, Beduneau, Ewan C, Goligher, Giacomo, Grasselli, Jon Henrik, Laake, Jordi, Mancebo, Oscar, Peñuela, Lise, Piquilloud, Antonio, Pesenti, Hannah, Wunsch, Frank, van Haren, Laurent, Brochard, John G, Laffey, Abrough, Fekri, P Acharya, Subhash, Amin, Pravin, Arabi, Yaseen, Aragao, Irene, Bauer, Philippe, Beduneau, Gaëtan, Beitler, Jeremy, Berkius, Johan, Bugedo, Guillermo, Camporota, Luigi, Cerny, Vladimir, Cho, Young-Jae, Clarkson, Kevin, Estenssoro, Elisa, Goligher, Ewan, Grasselli, Giacomo, Gritsan, Alexey, Mohammadreza Hashemian, Seyed, Hermans, Greet, M Heunks, Leo, Jovanovic, Bojan, Kurahashi, Kiyoyasu, Henrik Laake, Jon, Matamis, Dimitrio, Moerer, Onnen, Molnar, Zsolt, Ozyilmaz, Ezgi, Panka, Bernardo, Papali, Alfred, Peñuelas, Óscar, Perbet, Sébastien, Piquilloud, Lise, Qiu, Haibo, Abdel Razek, Assem, Rittayamai, Nuttapol, Roldan, Rollin, Serpa Neto, Ary, Szuldrzynski, Konstanty, Talmor, Daniel, Tomescu, Dana, Van Haren, Frank, Villagomez, Asisclo, Ali Zeggwagh, Amine, Abe, Toshikazu, Aboshady, Abdelrhman, Acampo-de Jong, Melanie, Acharya, Subhash, Adderley, Jane, Adiguzel, Nalan, Kumar Agrawal, Vijay, Aguilar, Gerardo, Aguirre, Gaston, Aguirre-Bermeo, Hernan, Ahlström, Björn, Akbas, Türkay, Akker, Mustafa, Al Sadeh, Ghamdan, Alamri, Sultan, Algaba, Angela, Ali, Muneeb, Aliberti, Anna, Manuel Allegue, Jose, Alvarez, Diana, Amador, Joaquin, H Andersen, Finn, Ansari, Sharique, Apichatbutr, Yutthana, Apostolopoulou, Olympia, Arellano, Daniel, Arica, Mestanza, Arikan, Huseyin, Arinaga, Koichi, Arnal, Jean-Michel, Asano, Kengo, Asín-Corrochano, Marta, Milagrito Avalos Cabrera, Jesu, Avila Fuentes, Silvia, Aydemir, Semih, Aygencel, Gulbin, Azevedo, Luciano, Bacakoglu, Feza, Badie, Julio, Baedorf Kassis, Elia, Bai, Gabriela, Balaraj, Govindan, Ballico, Bruno, Banner-Goodspeed, Valerie, Banwarie, Preveen, Barbieri, Rosella, Baronia, Arvind, Barrett, Jonathan, Barrot, Loïc, Emilio Barrueco-Francioni, Jesu, Barry, Jeffrey, Bawangade, Harshal, Beavis, Sarah, Beck, Eduardo, Beehre, Nina, Belenguer Muncharaz, Alberto, Bellani, Giacomo, Belliato, Mirko, Bellissima, Agrippino, Beltramelli, Rodrigo, Ben Souissi, Asma, Benitez-Cano, Adela, Benlamin, Mohamed, Benslama, Abdellatif, Bento, Lui, Benvenuti, Daniela, Bernabe, Laura, Bersten, Andrew, Berta, Giacomo, Bertini, Pietro, Bertram-Ralph, Elliot, Besbes, Mohamed, Roberto Bettini, Lisandro, Beuret, Pascal, Bewley, Jeremy, Bezzi, Marco, Bhakhtiani, Lakshay, Bhandary, Rakesh, Bhowmick, Kaushik, Bihari, Shailesh, Bissett, Bernie, Blythe, David, Bocher, Simon, Boedjawan, Narain, M Bojanowski, Christine, Boni, Elisa, Boraso, Sabrina, Borelli, Massimo, Borello, Silvina, Borislavova, Margarita, J Bosma, Karen, Bottiroli, Maurizio, Boyd, Owen, Bozbay, Suha, Briva, Arturo, Brochard, Laurent, Bruel, Cédric, Bruni, Andrea, Buehner, Ulrike, Bulpa, Pierre, Burt, Karen, Buscot, Mathieu, Buttera, Stefania, Cabrera, Jorge, Caccese, Roberta, Caironi, Pietro, Canchos Gutierrez, Ivan, Canedo, Nancy, Cani, Alma, Cappellini, Iacopo, Carazo, Jesu, Pablo Cardonnet, Lui, Carpio, David, Carriedo, Demetrio, Carrillo, Ramón, Carvalho, João, Caser, Eliana, Castelli, Antonio, Castillo Quintero, Manuel, Castro, Heloisa, Catorze, Nuno, Cengiz, Melike, Cereijo, Enrique, Ceunen, Helga, Chaintoutis, Christo, Chang, Youjin, Chaparro, Gustavogcha, Chapman, Carmel, Chau, Simon, Eugenia Chavez, Cecilia, Chelazzi, Cosimo, Chelly, Jonathan, Chemouni, Frank, Chen, Kai, Chena, Ariel, Chiarandini, Paolo, Chilton, Phil, Chiumello, Davide, Chou-Lie, Yvette, Chudeau, Nicola, Cinel, Ismail, Cinnella, Gilda, Clark, Michele, Clark, Thoma, Clementi, Stefano, Coaguila, Lui, Jaspe Codecido, Alexi, Collins, Amy, Colombo, Riccardo, Conde, Juan, Consales, Guglielmo, Cook, Tim, Coppadoro, Andrea, Cornejo, Rodrigo, Cortegiani, Andrea, Coxo, Cristina, Neville Cracchiolo, Andrea, Crespo Ramirez, Mónica, Crova, Philippe, Cruz, José, Cubattoli, Lucia, Çukurova, Zafer, Curto, Francesco, Czempik, Piotr, D'Andrea, Rocco, da Silva Ramos, Fernando, Dangers, Laurence, Danguy des Déserts, Marc, Danin, Pierre-Eric, Dantas, Fabianne, Daubin, Cédric, Dawei, Wu, de Haro, Candelaria, de Jesus Montelongo, Felipe, De Mendoza, Diego, de Pablo, Raúl, De Pascale, Gennaro, De Rosa, Silvia, Decavèle, Maxen, Declercq, Pierre-Loui, Deicas, Alberto, Del Carmen Campos Moreno, María, Dellamonica, Jean, Delmas, Benjamin, Demirkiran, Oktay, Demirkiran, Hilmi, Dendane, Tarek, di Mussi, Rossella, Diakaki, Chrysi, Diaz, Anatilde, Diaz, Willy, Dikmen, Yalim, Dimoula, Aikaterini, Doble, Patricia, Doha, Nagwa, Domingos, Guilherme, Dres, Martin, Dries, David, Duggal, Abhijit, Duke, Graeme, Dunts, Pavel, Dybwik, Knut, Dykyy, Maksym, Eckert, Philippe, Efe, Serdar, Elatrous, Souheil, Elay, Gülseren, S Elmaryul, Abubaker, Elsaadany, Mohamed, Elsayed, Hany, Elsayed, Samar, Emery, Malo, Ena, Sébastien, Eng, Kevin, A Englert, Joshua, Erdogan, Elif, Ergin Ozcan, Perihan, Eroglu, Ege, Escobar, Miguel, Esen, Figen, Esen Tekeli, Arzu, Esquivel, Alejandro, Esquivel Gallegos, Helbert, Ezzouine, Hanane, Facchini, Alberto, Faheem, Mohammad, Fanelli, Vito, Fernanda Farina, Maria, Fartoukh, Muriel, Fehrle, Lutz, Feng, Feng, Feng, Yufeng, Fernandez, Irene, Fernandez, Borja, Lorena Fernandez-Rodriguez, Maria, Ferrando, Carlo, João Ferreira da Silva, Maria, Ferreruela, Mireia, Ferrier, Janet, Jesús Flamm Zamorano, Matia, Flood, Laura, Floris, Leda, Fluckiger, Martin, Forteza, Catalina, Fortunato, Antonella, Frans, Eric, Frattari, Antonella, Fredes, Sebastian, Frenzel, Tim, Fumagalli, Roberto, Andres Furche, Mariano, Fusari, Maurizio, Fysh, Edward, Luis Galeas-Lopez, Juan, Galerneau, Louis-Marie, Garcia, Analía, Fernanda Garcia, María, Garcia, Elisabet, Garcia Olivares, Pablo, Garlicki, Jaroslaw, Garnero, Aude, Garofalo, Eugenio, Gautam, Prabha, Gazenkampf, Andrey, Gelinotte, Stéphanie, Gelormini, Domenico, Ghrenassia, Etienne, Giacomucci, Angelo, Giannoni, Robert, Gigante, Andrea, Glober, Nancy, Gnesin, Paolo, Gollo, Yari, Gomaa, Dina, Gomero Paredes, Rosita, Gomes, Rui, Alejandro Gomez, Raúl, Gomez, Oscar, Gomez, Aroa, Gondim, Louise, Gonzalez, Manuel, Gonzalez, Isabel, Gonzalez-Castro, Alejandro, Gordillo Romero, Orlando, Gordo, Federico, Gouin, Philippe, Graf Santos, Jerónimo, Grainne, Rooney, Grando, Matilde, Granov Grabovica, Sanja, Grasso, Salvatore, Grasso, Rinaldo, Grimmer, Lisa, Grissom, Colin, Gu, Qing, Guan, Xiang-Dong, Guarracino, Fabio, Guasch, Neu, Guatteri, Luca, Gueret, Renaud, Guérin, Claude, Guerot, Emmanuel, Guitard, Pierre-Gilda, Gül, Fethi, Gumus, Ayca, Gurjar, Mohan, Gutierrez, Patricia, Hachimi, Abdelhamid, Hadzibegovic, Adi, Hagan, Samantha, Hammel, Clare, Han Song, Joo, Hanlon, Gabrielle, Heines, Serge, Henriksson, Johanna, Herbrecht, Jean-Etienne, Omar Heredia Orbegoso, Gabriel, Hermon, Andrew, Hernandez, Rosana, Hernandez, Carmen, Herrera, Lui, Herrera-Gutierrez, Manuel, Heunks, Leo, Hidalgo, Juan, Hill, Dianne, Holmquist, Dagmar, Homez, Marcela, Hongtao, Xia, Hormis, Anil, Horner, Daniel, Carmen Hornos, M, Hou, Meihong, House, Stacy, Housni, Brahim, Hugill, Keith, Humphreys, Sally, Humbert, Loui, Hunter, Stephanie, Hwa Young, Lee, Iezzi, Nicola, Ilutovich, Santiago, Inal, Volkan, Innes, Richard, Ioannides, Panagioti, Antonio Iotti, Giorgio, Ippolito, Mariachiara, Irie, Hiromasa, Iriyama, Hiroki, Itagaki, Taiga, Izura, Javier, Izza, Santiago, Jabeen, Rakhshanda, Jamaati, Hamidreza, Jamadarkhana, Sunil, Jamoussi, Amira, Jankowski, Milosz, Alberto Jaramillo, Lui, Jeon, Kyeongman, Jeong Lee, Seok, Jeswani, Deepak, Jha, Simant, Jiang, Liangyan, Jing, Chen, Jochmans, Sébastien, Anders Johnstad, Bror, Jongmin, Lee, Joret, Aurélie, Junhasavasdikul, Detajin, Teresa Jurado, Maria, Kam, Elisa, Kamohara, Hidenobu, Kane, Caroline, Kara, Iskender, Karakurt, Sait, Karnjanarachata, Cherdkiat, Kataoka, Jun, Katayama, Shinshu, Kaushik, Shuchi, Kelebek Girgin, Nermin, Kerr, Kathryn, Kerslake, Ian, Khairnar, Prakash, Khalid, Abidi, Khan, Akram, K Khanna, Ashish, Khorasanee, Reza, Kienhorst, Dieneke, Kirakli, Cenk, Knafelj, Rihard, Kol Kol, Mark, Kongpolprom, Napplika, Kopitko, Csaba, Korkmaz Ekren, Pervin, Kubisz-Pudelko, Agnieszka, Kulcsar, Zoltan, Kumasawa, Junji, Kuriyama, Akira, Kutchak, Fernanda, Labarca, Eduardo, Labat, Françoise, Laborda, César, Alberto Laca Barrera, Manuel, Lagache, Laurie, Landaverde Lopez, Antonio, Lanspa, Michael, Lascari, Valeria, Le Meur, Matthieu, Hwan Lee, Su, Ju Lee, Young, Lee, Jinwoo, Lee, Won-Yeon, Lee, Jarone, Legernaes, Terje, Leiner, Tamaa, Lemiale, Virginie, Leonor, Tiago, M Lepper, Philipp, Li, Dahuan, Li, Hongbin, Li, Oleg, Raquel Lima, Ana, Lind, Dan, Litton, Edward, Liu, Ning, Liu, Ling, Liu, Jialin, Llitjos, Jean-Françoi, Llorente, Beatriz, Lopez, Rodolfo, Elizabeth Lopez, Claudia, Lopez Nava, Claudia, Lovazzano, Pablo, Lu, Min, Lucchese, Francesca, Lugano, Manuela, Lugo Goytia, Gustavo, Luo, Hua, Lynch, Ceri, Macheda, Sebastiano, Hugo Madrigal Robles, Victor, Maurizio Maggiore, Salvatore, Magret Iglesias, Mònica, Malaga, Peter, Mallapura Maheswarappa, Harish, Malpartida, Guillermo, Malyarchikov, Andrey, Mansson, Helena, Manzano, Anaid, Marey, Ismael, Marin, Nathalie, Del Carmen Marin, Maria, Markman, Eliana, Martin, Felix, Martin, Alex, Martin Dal Gesso, Cristina, Martinez, Felipe, Martínez-Fidalgo, Conchita, Martin-Loeches, Ignacio, Mas, Arantxa, Masaaki, Sakuraya, Maseda, Emilio, Massa, Eleni, Mattsson, Anna, Maugeri, Jessica, Mccredie, Victoria, Mccullough, Jame, Mcguinness, Shay, Mckown, Andrew, Medve, László, Mei, Chengqing, Mellado Artigas, Ricard, Mendes, Vitor, Khalaf Ebraheim Mervat, Mohamed, Michaux, Isabelle, Mikhaeil, Michael, Milagros, Olga, Milet, Igor, Teresa Millan, Maria, Minwei, Zhang, Mirabella, Lucia, Mishra, Sanghamitra, Mistraletti, Giovanni, Mochizuki, Katsunori, Moghal, Arif, Mojoli, Francesco, Molin, Alexandre, Montiel, Raquel, Montini, Luca, Monza, Gianmario, Mora Aznar, Maria, Morakul, Sunthiti, Morales, Maria, Moreno Torres, Daniel, Rolando Morocho Tutillo, Diego, Motherway, Catherine, Mouhssine, Doumiri, Mouloudi, Eleni, Muñoz, Tapia, Munoz de Cabo, Carlo, Mustafa, Mohamed, Muthuchellappan, Radhakrishnan, Muthukrishnan, Muraleekrishnan, Muttini, Stefano, Nagata, Isao, Nahar, Dick, Nakanishi, Misuzu, Nakayama, Izumi, Antonio Namendys-Silva, Silvio, Nanchal, Rahul, Nandakumar, Sivakumar, Nasi, Alessandra, Nasir, Kamal, Navalesi, Paolo, Naz Aslam, Tayyba, Nga Phan, Thuy, Nichol, Alistair, Niiyama, Shuhei, Nikolakopoulou, Sofia, Nikolic, Elena, Nitta, Kenichi, Noc, Marko, Nonas, Stephanie, Nseir, Saad, Nur Soyturk, Ayse, Obata, Yukako, Oeckler, Richard, Oguchi, Moe, Ohshimo, Shinichiro, Oikonomou, Marina, Ojados, Agueda, Teresa Oliveira, Maria, Oliveira Filho, Wilson, Oliveri, Carlo, Olmos, Aitor, Omura, Kazuya, Cristina Orlandi, Maria, Orsenigo, Francesca, Ortiz-Ruiz De Gordoa, Laura, Ota, Kei, Ovalle Olmos, Rainier, Öveges, Nándo, Oziemski, Peter, Ozkan Kuscu, Ozlem, Özyilmaz, Ezgi, Pachas Alvarado, Fernando, Pagella, Gonzalo, Palaniswamy, Vijayanand, Luis Palazon Sanchez, Eugenio, Palmese, Salvatore, Pan, Guojun, Pan, Wensen, Papanikolaou, Metaxia, Papavasilopoulou, Theonymfi, Parekh, Ameet, Parke, Rachael, J Parrilla, Francisco, Parrilla, Dácil, Pasha, Taha, Pasin, Laura, Patão, Lui, Patel, Mayur, Patel, Grisma, Kumar Pati, Basanta, Patil, Jayaprakash, Pattnaik, Saroj, Paul, Daniel, Pavesi, Maurizio, Alejandra Pavlotsky, Vanesa, Paz, Graciela, Paz, Enrique, Pecci, Elisabetta, Pellegrini, Carlo, Gabriela Peña Padilla, Andrea, Perchiazzi, Gaetano, Pereira, Tiago, Pereira, Vera, Perez, Manuel, Perez Calvo, Cesar, Perez Cheng, Meisy, Perez Maita, Ronald, Pérez-Araos, Rodrigo, Perez-Teran, Purificación, Perez-Torres, David, Perkins, Gavin, Persona, Paolo, Petnak, Tananchai, Petrova, Marina, Pham, Tai, Philippart, Françoi, Picetti, Edoardo, Pierucci, Elisabetta, Piervincenzi, Edoardo, Pinciroli, Riccardo, Pintado, Maria-Consuelo, Piraino, Thoma, Piras, Stephanie, Piras, Claudio, Pirompanich, Pattarin, Pisani, Luigi, Platas, Enrique, Plotnikow, Gustavo, Porras, Willy, Porta, Virginia, Portilla, Mariana, Portugal, José, Povoa, Pedro, Prat, Gwenael, Pratto, Romina, Preda, Gabriel, Prieto, Isidro, Prol-Silva, Estefania, Pugh, Richard, Qi, Yupeng, Qian, Chuanyun, Qin, Tiehe, Qu, Hongping, Quintana, Teobaldo, Quispe Sierra, Rosari, Quispe Soto, Rocio, Rabbani, Raihan, Rabee, Mohamed, Rabie, Ahmed, Augusta Rahe Pereira, Maria, Rai, Ashish, Raj Ashok, Sundar, Rajab, Mostafa, Ramdhani, Navin, Ramey, Elizabeth, Ranieri, Marco, Rathod, Darshana, Ray, Banambar, Mahmud Redwanul Huq, Shihan, Regli, Adrian, Reina, Rosa, Resano Sarmiento, Natalia, Reynaud, Faustine, Rialp, Gemma, Ricart, Pilar, Rice, Todd, Richardson, Angu, Rieder, Marcelo, Rinket, Martin, Rios, Fernando, Risso Vazquez, Alejandro, Riva, Ivano, Rivette, Monaly, Roca, Oriol, Roche-Campo, Ferran, Rodriguez, Covadonga, Rodriguez, Gabriel, Rodriguez Gonzalez, Daniel, Yanina Rodriguez Tucto, Xandra, Rogers, Angela, Elena Romano, María, Rørtveit, Linda, Rose, Alastair, Roux, Damien, Rouze, Anahita, Nahuel Rubatto Birri, Paolo, Ruilan, Wang, Ruiz Robledo, Aldana, Luis Ruiz-Aguilar, Antonio, Sadahiro, Tomohito, Saez, Ignacio, Sagardia, Judith, Saha, Rajnish, Saha, Rohit, Saiphoklang, Narongkorn, Saito, Shigeki, Salem, Maie, Sales, Gabriele, Salgado, Patricia, Samavedam, Sriniva, Sami Mebazaa, Mhamed, Samuelsson, Line, San Juan Roman, Nandyelly, Sanchez, Patricia, Sanchez-Ballesteros, Jesu, Sandoval, Yazcitk, Sani, Emanuele, Santos, Martin, Santos, Carla, Sanui, Masamitsu, Saravanabavan, Lakshmikanthcharan, Sari, Sema, Sarkany, Agne, Sauneuf, Bertrand, Savioli, Monica, Sazak, Hilal, Scano, Riccardo, Schneider, Franci, Schortgen, Frédérique, J Schultz, Marcu, Leonie Schwarz, Gabriele, Seçkin Yücesoy, Faruk, Seely, Andrew, Seiler, Frederik, Seker Tekdos, Yasemin, Seok Chan, Kim, Serano, Luca, Serednicki, Wojciech, Setten, Mariano, Shah, Asim, Shah, Bhagyesh, Shang, You, Shanmugasundaram, Pradeep, Shapovalov, Konstantin, Shebl, Eman, Shiga, Takuya, Shime, Nobuaki, Shin, Phil, Short, Jack, Shuhua, Chen, Siddiqui, Sughrat, Ignacio Silesky Jimenez, Juan, Silva, Daniel, Silva Sales, Betania, Simons, Koen, Ågot Sjøbø, Brit, Slessor, David, Smiechowicz, Jakub, Smischney, Nathan, Smith, Paul, Smith, Tim, Smith, Mark, Snape, Sarah, Snyman, Lindi, Soetens, Filiep, Sook Hong, Kyung, Ángel Sosa Medellin, Miguel, Soto, Giovanna, Souloy, Xavier, Sousa, Elsa, Sovatzis, Stefania, Sozutek, Didem, Spadaro, Savino, Spagnoli, Marco, Spångfors, Martin, Spittle, Nick, Spivey, Mike, Stapleton, Andrew, Stefanovic, Branislava, Stephenson, Lorraine, Stevenson, Elizabeth, Strand, Kristian, Teresa Strano, Maria, Straus, Slavenka, Sun, Chenliang, Sun, Rongqing, Sundaram, Venkat, Sunpark, Tai, Surlemont, Elisabeth, Sutherasan, Yuda, Szabo, Zsuzsanna, Tainter, Christopher, Takaba, Akihiro, Tallott, 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Maseda, Eleni Massa, Anna Mattsson, Jessica Maugeri, Victoria McCredie, James McCullough, Shay McGuinness, Andrew McKown, László Medve, Chengqing Mei, Ricard Mellado Artigas, Vitor Mendes, Mohamed Khalaf Ebraheim Mervat, Isabelle Michaux, Michael Mikhaeil, Olga Milagros, Igor Milet, Maria Teresa Millan, Zhang Minwei, Lucia Mirabella, Sanghamitra Mishra, Giovanni Mistraletti, Katsunori Mochizuki, Arif Moghal, Francesco Mojoli, Alexandre Molin, Raquel Montiel, Luca Montini (ORCID:0000-0003-4602-5134), Gianmario Monza, Maria Mora Aznar, Sunthiti Morakul, Maria Morales, Daniel Moreno Torres, Diego Rolando Morocho Tutillo, Catherine Motherway, Doumiri Mouhssine, Eleni Mouloudi, Tapia Muñoz, Carlos Munoz de Cabo, Mohamed Mustafa, Radhakrishnan Muthuchellappan, Muraleekrishnan Muthukrishnan, Stefano Muttini, Isao Nagata, Dick Nahar, Misuzu Nakanishi, Izumi Nakayama, Silvio Antonio Namendys-Silva, Rahul Nanchal, Sivakumar Nandakumar, Alessandra Nasi, Kamal Nasir, Paolo Navalesi, Tayyba Naz 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Kassis, Gabriela Bai, Govindan Balaraj, Bruno Ballico, Valerie Banner-Goodspeed, Preveen Banwarie, Rosella Barbieri, Arvind Baronia, Jonathan Barrett, Loïc Barrot, Jesus Emilio Barrueco-Francioni, Jeffrey Barry, Harshal Bawangade, Sarah Beavis, Eduardo Beck, Nina Beehre, Alberto Belenguer Muncharaz, Giacomo Bellani, Mirko Belliato, Agrippino Bellissima, Rodrigo Beltramelli, Asma Ben Souissi, Adela Benitez-Cano, Mohamed Benlamin, Abdellatif Benslama, Luis Bento, Daniela Benvenuti, Laura Bernabe, Andrew Bersten, Giacomo Berta, Pietro Bertini, Elliot Bertram-Ralph, Mohamed Besbes, Lisandro Roberto Bettini, Pascal Beuret, Jeremy Bewley, Marco Bezzi, Lakshay Bhakhtiani, Rakesh Bhandary, Kaushik Bhowmick, Shailesh Bihari, Bernie Bissett, David Blythe, Simon Bocher, Narain Boedjawan, Christine M Bojanowski, Elisa Boni, Sabrina Boraso, Massimo Borelli, Silvina Borello, Margarita Borislavova, Karen J Bosma, Maurizio Bottiroli, Owen Boyd, Suha Bozbay, Arturo Briva, Laurent Brochard, Cédric Bruel, Andrea Bruni, Ulrike Buehner, Pierre Bulpa, Karen Burt, Mathieu Buscot, Stefania Buttera, Jorge Cabrera, Roberta Caccese, Pietro Caironi, Ivan Canchos Gutierrez, Nancy Canedo, Alma Cani, Iacopo Cappellini, Jesus Carazo, Luis Pablo Cardonnet, David Carpio, Demetrio Carriedo, Ramón Carrillo, João Carvalho, Eliana Caser, Antonio Castelli, Manuel Castillo Quintero, Heloisa Castro, Nuno Catorze, Melike Cengiz, Enrique Cereijo, Helga Ceunen, Christos Chaintoutis, Youjin Chang, Gustavogcha Chaparro, Carmel Chapman, Simon Chau, Cecilia Eugenia Chavez, Cosimo Chelazzi, Jonathan Chelly, Frank Chemouni, Kai Chen, Ariel Chena, Paolo Chiarandini, Phil Chilton, Davide Chiumello, Yvette Chou-Lie, Nicolas Chudeau, Ismail Cinel, Gilda Cinnella, Michele Clark, Thomas Clark, Stefano Clementi, Luis Coaguila, Alexis Jaspe Codecido, Amy Collins, Riccardo Colombo, Juan Conde, Guglielmo Consales, Tim Cook, Andrea Coppadoro, Rodrigo Cornejo, Andrea Cortegiani, Cristina Coxo, Andrea Neville Cracchiolo, Mónica Crespo Ramirez, Philippe Crova, José Cruz, Lucia Cubattoli, Zafer Çukurova, Francesco Curto, Piotr Czempik, Rocco D'Andrea, Fernando da Silva Ramos, Laurence Dangers, Marc Danguy des Déserts, Pierre-Eric Danin, Fabianne Dantas, Cédric Daubin, Wu Dawei, Candelaria de Haro, Felipe de Jesus Montelongo, Diego De Mendoza, Raúl de Pablo, Gennaro De Pascale, Silvia De Rosa, Maxens Decavèle, Pierre-Louis Declercq, Alberto Deicas, María Del Carmen Campos Moreno, Jean Dellamonica, Benjamin Delmas, Oktay Demirkiran, Hilmi Demirkiran, Tarek Dendane, Rossella di Mussi, Chrysi Diakaki, Anatilde Diaz, Willy Diaz, Yalim Dikmen, Aikaterini Dimoula, Patricia Doble, Nagwa Doha, Guilherme Domingos, Martin Dres, David Dries, Abhijit Duggal, Graeme Duke, Pavel Dunts, Knut Dybwik, Maksym Dykyy, Philippe Eckert, Serdar Efe, Souheil Elatrous, Gülseren Elay, Abubaker S Elmaryul, Mohamed Elsaadany, Hany Elsayed, Samar Elsayed, Malo Emery, Sébastien Ena, Kevin Eng, Joshua A Englert, Elif Erdogan, Perihan Ergin Ozcan, Ege Eroglu, Miguel Escobar, Figen Esen, Arzu Esen Tekeli, Alejandro Esquivel, Helbert Esquivel Gallegos, Hanane Ezzouine, Alberto Facchini, Mohammad Faheem, Vito Fanelli, Maria Fernanda Farina, Muriel Fartoukh, Lutz Fehrle, Feng Feng, Yufeng Feng, Irene Fernandez, Borja Fernandez, Maria Lorena Fernandez-Rodriguez, Carlos Ferrando, Maria João Ferreira da Silva, Mireia Ferreruela, Janet Ferrier, Matias Jesús Flamm Zamorano, Laura Flood, Leda Floris, Martin Fluckiger, Catalina Forteza, Antonella Fortunato, Eric Frans, Antonella Frattari, Sebastian Fredes, Tim Frenzel, Roberto Fumagalli, Mariano Andres Furche, Maurizio Fusari, Edward Fysh, Juan Luis Galeas-Lopez, Louis-Marie Galerneau, Analía Garcia, María Fernanda Garcia, Elisabet Garcia, Pablo Garcia Olivares, Jaroslaw Garlicki, Aude Garnero, Eugenio Garofalo, Prabha Gautam, Andrey Gazenkampf, Stéphanie Gelinotte, Domenico Gelormini, Etienne Ghrenassia, Angelo Giacomucci, Robert Giannoni, Andrea Gigante, Nancy Glober, Paolo Gnesin, Yari Gollo, Dina Gomaa, Rosita Gomero Paredes, Rui Gomes, Raúl Alejandro Gomez, Oscar Gomez, Aroa Gomez, Louise Gondim, Manuel Gonzalez, Isabel Gonzalez, Alejandro Gonzalez-Castro, Orlando Gordillo Romero, Federico Gordo, Philippe Gouin, Jerónimo Graf Santos, Rooney Grainne, Matilde Grando, Sanja Granov Grabovica, Salvatore Grasso, Rinaldo Grasso, Lisa Grimmer, Colin Grissom, Qing Gu, Xiang-Dong Guan, Fabio Guarracino, Neus Guasch, Luca Guatteri, Renaud Gueret, Claude Guérin, Emmanuel Guerot, Pierre-Gildas Guitard, Fethi Gül, Ayca Gumus, Mohan Gurjar, Patricia Gutierrez, Abdelhamid Hachimi, Adi Hadzibegovic, Samantha Hagan, Clare Hammel, Joo Han Song, Gabrielle Hanlon, Serge Heines, Johanna Henriksson, Jean-Etienne Herbrecht, Gabriel Omar Heredia Orbegoso, Andrew Hermon, Rosana Hernandez, Carmen Hernandez, Luis Herrera, Manuel Herrera-Gutierrez, Leo Heunks, Juan Hidalgo, Dianne Hill, Dagmar Holmquist, Marcela Homez, Xia Hongtao, Anil Hormis, Daniel Horner, M Carmen Hornos, Meihong Hou, Stacy House, Brahim Housni, Keith Hugill, Sally Humphreys, Louis Humbert, Stephanie Hunter, Lee Hwa Young, Nicolas Iezzi, Santiago Ilutovich, Volkan Inal, Richard Innes, Panagiotis Ioannides, Giorgio Antonio Iotti, Mariachiara Ippolito, Hiromasa Irie, Hiroki Iriyama, Taiga Itagaki, Javier Izura, Santiago Izza, Rakhshanda Jabeen, Hamidreza Jamaati, Sunil Jamadarkhana, Amira Jamoussi, Milosz Jankowski, Luis Alberto Jaramillo, Kyeongman Jeon, Seok Jeong Lee, Deepak Jeswani, Simant Jha, Liangyan Jiang, Chen Jing, Sébastien Jochmans, Bror Anders Johnstad, Lee Jongmin, Aurélie Joret, Detajin Junhasavasdikul, Maria Teresa Jurado, Elisa Kam, Hidenobu Kamohara, Caroline Kane, Iskender Kara, Sait Karakurt, Cherdkiat Karnjanarachata, Jun Kataoka, Shinshu Katayama, Shuchi Kaushik, Nermin Kelebek Girgin, Kathryn Kerr, Ian Kerslake, Prakash Khairnar, Abidi Khalid, Akram Khan, Ashish K Khanna, Reza Khorasanee, Dieneke Kienhorst, Cenk Kirakli, Rihard Knafelj, Mark Kol Kol, Napplika Kongpolprom, Csaba Kopitko, Pervin Korkmaz Ekren, Agnieszka Kubisz-Pudelko, Zoltan Kulcsar, Junji Kumasawa, Akira Kuriyama, Fernanda Kutchak, Eduardo Labarca, Françoise Labat, César Laborda, Manuel Alberto Laca Barrera, Laurie Lagache, Antonio Landaverde Lopez, Michael Lanspa, Valeria Lascari, Matthieu Le Meur, Su Hwan Lee, Young Ju Lee, Jinwoo Lee, Won-Yeon Lee, Jarone Lee, Terje Legernaes, Tamaas Leiner, Virginie Lemiale, Tiago Leonor, Philipp M Lepper, Dahuan Li, Hongbin Li, Oleg Li, Ana Raquel Lima, Dan Lind, Edward Litton, Ning Liu, Ling Liu, Jialin Liu, Jean-François Llitjos, Beatriz Llorente, Rodolfo Lopez, Claudia Elizabeth Lopez, Claudia Lopez Nava, Pablo Lovazzano, Min Lu, Francesca Lucchese, Manuela Lugano, Gustavo Lugo Goytia, Hua Luo, Ceri Lynch, Sebastiano Macheda, Victor Hugo Madrigal Robles, Salvatore Maurizio Maggiore, Mònica Magret Iglesias, Peter Malaga, Harish Mallapura Maheswarappa, Guillermo Malpartida, Andrey Malyarchikov, Helena Mansson, Anaid Manzano, Ismael Marey, Nathalie Marin, Maria Del Carmen Marin, Eliana Markman, Felix Martin, Alex Martin, Cristina Martin Dal Gesso, Felipe Martinez, Conchita Martínez-Fidalgo, Ignacio Martin-Loeches, Arantxa Mas, Sakuraya Masaaki, Emilio Maseda, Eleni Massa, Anna Mattsson, Jessica Maugeri, Victoria McCredie, James McCullough, Shay McGuinness, Andrew McKown, László Medve, Chengqing Mei, Ricard Mellado Artigas, Vitor Mendes, Mohamed Khalaf Ebraheim Mervat, Isabelle Michaux, Michael Mikhaeil, Olga Milagros, Igor Milet, Maria Teresa Millan, Zhang Minwei, Lucia Mirabella, Sanghamitra Mishra, Giovanni Mistraletti, Katsunori Mochizuki, Arif Moghal, Francesco Mojoli, Alexandre Molin, Raquel Montiel, Luca Montini (ORCID:0000-0003-4602-5134), Gianmario Monza, Maria Mora Aznar, Sunthiti Morakul, Maria Morales, Daniel Moreno Torres, Diego Rolando Morocho Tutillo, Catherine Motherway, Doumiri Mouhssine, Eleni Mouloudi, Tapia Muñoz, Carlos Munoz de Cabo, Mohamed Mustafa, Radhakrishnan Muthuchellappan, Muraleekrishnan Muthukrishnan, Stefano Muttini, Isao Nagata, Dick Nahar, Misuzu Nakanishi, Izumi Nakayama, Silvio Antonio Namendys-Silva, Rahul Nanchal, Sivakumar Nandakumar, Alessandra Nasi, Kamal Nasir, Paolo Navalesi, Tayyba Naz Aslam, Thuy Nga Phan, Alistair Nichol, Shuhei Niiyama, Sofia Nikolakopoulou, Elena Nikolic, Kenichi Nitta, Marko Noc, Stephanie Nonas, Saad Nseir, Ayse Nur Soyturk, Yukako Obata, Richard Oeckler, Moe Oguchi, Shinichiro Ohshimo, Marina Oikonomou, Agueda Ojados, Maria Teresa Oliveira, Wilson Oliveira Filho, Carlo Oliveri, Aitor Olmos, Kazuya Omura, Maria Cristina Orlandi, Francesca Orsenigo, Laura Ortiz-Ruiz De Gordoa, Kei Ota, Rainier Ovalle Olmos, Nándo Öveges, Peter Oziemski, Ozlem Ozkan Kuscu, Ezgi Özyilmaz, Fernando Pachas Alvarado, Gonzalo Pagella, Vijayanand Palaniswamy, Eugenio Luis Palazon Sanchez, Salvatore Palmese, Guojun Pan, Wensen Pan, Metaxia Papanikolaou, Theonymfi Papavasilopoulou, Ameet Parekh, Rachael Parke, Francisco J Parrilla, Dácil Parrilla, Taha Pasha, Laura Pasin, Luis Patão, Mayur Patel, Grisma Patel, Basanta Kumar Pati, Jayaprakash Patil, Saroj Pattnaik, Daniel Paul, Maurizio Pavesi, Vanesa Alejandra Pavlotsky, Graciela Paz, Enrique Paz, Elisabetta Pecci, Carlos Pellegrini, Andrea Gabriela Peña Padilla, Gaetano Perchiazzi, Tiago Pereira, Vera Pereira, Manuel Perez, Cesar Perez Calvo, Meisy Perez Cheng, Ronald Perez Maita, Rodrigo Pérez-Araos, Purificación Perez-Teran, David Perez-Torres, Gavin Perkins, Paolo Persona, Tananchai Petnak, Marina Petrova, Tai Pham, François Philippart, Edoardo Picetti, Elisabetta Pierucci, Edoardo Piervincenzi, Riccardo Pinciroli, Maria-Consuelo Pintado, Thomas Piraino, Stephanie Piras, Claudio Piras, Pattarin Pirompanich, Luigi Pisani, Enrique Platas, Gustavo Plotnikow, Willy Porras, Virginia Porta, Mariana Portilla, José Portugal, Pedro Povoa, Gwenael Prat, Romina Pratto, Gabriel Preda, Isidro Prieto, Estefania Prol-Silva, Richard Pugh, Yupeng Qi, Chuanyun Qian, Tiehe Qin, Hongping Qu, Teobaldo Quintana, Rosari Quispe Sierra, Rocio Quispe Soto, Raihan Rabbani, Mohamed Rabee, Ahmed Rabie, Maria Augusta Rahe Pereira, Ashish Rai, Sundar Raj Ashok, Mostafa Rajab, Navin Ramdhani, Elizabeth Ramey, Marco Ranieri, Darshana Rathod, Banambar Ray, Shihan Mahmud Redwanul Huq, Adrian Regli, Rosa Reina, Natalia Resano Sarmiento, Faustine Reynaud, Gemma Rialp, Pilar Ricart, Todd Rice, Angus Richardson, Marcelo Rieder, Martin Rinket, Fernando Rios, Alejandro Risso Vazquez, Ivano Riva, Monaly Rivette, Oriol Roca, Ferran Roche-Campo, Covadonga Rodriguez, Gabriel Rodriguez, Daniel Rodriguez Gonzalez, Xandra Yanina Rodriguez Tucto, Angela Rogers, María Elena Romano, Linda Rørtveit, Alastair Rose, Damien Roux, Anahita Rouze, Paolo Nahuel Rubatto Birri, Wang Ruilan, Aldana Ruiz Robledo, Antonio Luis Ruiz-Aguilar, Tomohito Sadahiro, Ignacio Saez, Judith Sagardia, Rajnish Saha, Rohit Saha, Narongkorn Saiphoklang, Shigeki Saito, Maie Salem, Gabriele Sales, Patricia Salgado, Srinivas Samavedam, Mhamed Sami Mebazaa, Line Samuelsson, Nandyelly San Juan Roman, Patricia Sanchez, Jesus Sanchez-Ballesteros, Yazcitk Sandoval, Emanuele Sani, Martin Santos, Carla Santos, Masamitsu Sanui, Lakshmikanthcharan Saravanabavan, Sema Sari, Agnes Sarkany, Bertrand Sauneuf, Monica Savioli, Hilal Sazak, Riccardo Scano, Francis Schneider, Frédérique Schortgen, Marcus J Schultz, Gabriele Leonie Schwarz, Faruk Seçkin Yücesoy, Andrew Seely, Frederik Seiler, Yasemin Seker Tekdos, Kim Seok Chan, Luca Serano, Wojciech Serednicki, Mariano Setten, Asim Shah, Bhagyesh Shah, You Shang, Pradeep Shanmugasundaram, Konstantin Shapovalov, Eman Shebl, Takuya Shiga, Nobuaki Shime, Phil Shin, Jack Short, Chen Shuhua, Sughrat Siddiqui, Juan Ignacio Silesky Jimenez, Daniel Silva, Betania Silva Sales, Koen Simons, Brit Ågot Sjøbø, David Slessor, Jakub Smiechowicz, Nathan Smischney, Paul Smith, Tim Smith, Mark Smith, Sarah Snape, Lindi Snyman, Filiep Soetens, Kyung Sook Hong, Miguel Ángel Sosa Medellin, Giovanna Soto, Xavier Souloy, Elsa Sousa, Stefania Sovatzis, Didem Sozutek, Savino Spadaro, Marco Spagnoli, Martin Spångfors, Nick Spittle, Mike Spivey, Andrew Stapleton, Branislava Stefanovic, Lorraine Stephenson, Elizabeth Stevenson, Kristian Strand, Maria Teresa Strano, Slavenka Straus, Chenliang Sun, Rongqing Sun, Venkat Sundaram, Tai SunPark, Elisabeth Surlemont, Yuda Sutherasan, Zsuzsanna Szabo, Christopher Tainter, Akihiro Takaba, Mandy Tallott, Tamasato Tamasato, Zhanhong Tang, Viratch Tangsujaritvijit, Leandro Taniguchi, Daisuke Taniguchi, Fabio Tarantino, Krittika Teerapuncharoen, Susana Temprano, Pierpaolo Terragni, Nicolas Terzi, Anand Thakur, Pongdhep Theerawit, Arnaud W Thille, Matt Thomas, Poungrat Thungtitigul, Martial Thyrault, Nejla Tilouch, Karina Timenetsky, Juna Tirapu, Manuel Todeschini, Roser Tomas, Christian Tomaszewski, Tommaso Tonetti, Alexandre Tonnelier, John Trinder, Konlawij Trongtrakul, Jonathon Truwit, Betty Tsuei, Aiman Tulaimat, Sema Turan, Melda Turkoglu, Sanjeev Tyagi, Alejandro Ubeda, Federica Vagginelli, María Florencia Valenti, Imma Vallverdu, Alisha Van Axel, Ingrid van den Hul, Hans van der Hoeven, Nardo Van Der Meer, Marc Vanhoof, Mónica Vargas-Ordoñez, Rosanna Vaschetto, Ettore Vascotto, Maria Vatsik, Ana Vaz, Antonia Vazquez-Sanchez, Sara Ventura, Jan Wytze Vermeijden, Anxela Vidal, Jocyelle Vieira, Bruno Vilela Costa Pinto, Ana Villagra, Cristina Villegas Succar, Ole Georg Vinorum, Giovanni Vitale, Ramesh Vj, Ana Vochin, Guillaume Voiriot, Carlo Alberto Volta, Magnus von Seth, Maazouzi Wajdi, Don Walsh, Shouhong Wang, Gabriel Wardi, Nils Christian Ween-Velken, Bi-Lin Wei, Dolf Weller, Deborah Welsh, Ingeborg Welters, Michael Wert, Simon Whiteley, Elizabeth Wilby, Erin Williams, Karen Williams, Antoinette Wilson, Jadwiga Wojtas, Jin Won Huh, David Wrathall, Christopher Wright, Jian-Feng Wu, Guo Xi, Zheng-Jiang Xing, Hongyang Xu, Kotaro Yamamoto, Jie Yan, Julio Yáñez, Xiaobo Yang, Elliot Yates, Ozlem Yazicioglu Mocin, Zhenglong Ye, Fatma Yildirim, Norifumi Yoshida, Hector Higo Leon Yoshido, Bo Young Lee, Rongguo Yu, Gong Yu, Tao Yu, Boyun Yuan, Nadwipa Yuangtrakul, Tetsuya Yumoto, Xie Yun, Graciela Zakalik, Ahmad Zaki, Begoña Zalba-Etayo, Massimo Zambon, Bin Zang, Gianluca Zani, Jonathan Zarka, Simone Maria Zerbi, Avsar Zerman, Harald Zetterquist, Jiuzhi Zhang, Hongwen Zhang, Wei Zhang, Guoxiu Zhang, Weixin Zhang, Hongsheng Zhao, Jia Zheng, Bin Zhu, and Ronald Zumaran
Abstract: Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0-4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d
Published: 2023

19. AVALON: The Italian cohort study on real-life efficacy of hypomethylating agents plus venetoclax in newly diagnosed or relapsed/refractory patients with acute myeloid leukemia

Author: Todisco, E, Papayannidis, C, Fracchiolla, N, Petracci, E, Zingaretti, C, Vetro, C, Martelli, M, Zappasodi, P, Di Renzo, N, Gallo, S, Audisio, E, Griguolo, D, Cerchione, C, Selleri, C, Mattei, D, Bernardi, M, Fumagalli, M, Rizzuto, G, Facchini, L, Basilico, C, Manfra, I, Borlenghi, E, Cairoli, R, Salutari, P, Gottardi, M, Molteni, A, Martini, V, Lunghi, M, Fianchi, L, Cilloni, D, Lanza, F, Abruzzese, E, Cascavilla, N, Rivellini, F, Ferrara, F, Maurillo, L, Nanni, J, Romano, A, Cardinali, V, Gigli, F, Roncoroni, E, Federico, V, Marconi, G, Volpi, R, Sciumè, M, Tarella, C, Rossi, G, Martinelli, G, Todisco E, Papayannidis C, Fracchiolla N, Petracci E, Zingaretti C, Vetro C, Martelli MP, Zappasodi P, Di Renzo N, Gallo S, Audisio E, Griguolo D, Cerchione C, Selleri C, Mattei D, Bernardi M, Fumagalli M, Rizzuto G, Facchini L, Basilico CM, Manfra I, Borlenghi E, Cairoli R, Salutari P, Gottardi M, Molteni A, Martini V, Lunghi M, Fianchi L, Cilloni D, Lanza F, Abruzzese E, Cascavilla N, Rivellini F, Ferrara F, Maurillo L, Nanni J, Romano A, Cardinali V, Gigli F, Roncoroni E, Federico V, Marconi G, Volpi R, Sciumè M, Tarella C, Rossi G, Martinelli G, Todisco, E, Papayannidis, C, Fracchiolla, N, Petracci, E, Zingaretti, C, Vetro, C, Martelli, M, Zappasodi, P, Di Renzo, N, Gallo, S, Audisio, E, Griguolo, D, Cerchione, C, Selleri, C, Mattei, D, Bernardi, M, Fumagalli, M, Rizzuto, G, Facchini, L, Basilico, C, Manfra, I, Borlenghi, E, Cairoli, R, Salutari, P, Gottardi, M, Molteni, A, Martini, V, Lunghi, M, Fianchi, L, Cilloni, D, Lanza, F, Abruzzese, E, Cascavilla, N, Rivellini, F, Ferrara, F, Maurillo, L, Nanni, J, Romano, A, Cardinali, V, Gigli, F, Roncoroni, E, Federico, V, Marconi, G, Volpi, R, Sciumè, M, Tarella, C, Rossi, G, Martinelli, G, Todisco E, Papayannidis C, Fracchiolla N, Petracci E, Zingaretti C, Vetro C, Martelli MP, Zappasodi P, Di Renzo N, Gallo S, Audisio E, Griguolo D, Cerchione C, Selleri C, Mattei D, Bernardi M, Fumagalli M, Rizzuto G, Facchini L, Basilico CM, Manfra I, Borlenghi E, Cairoli R, Salutari P, Gottardi M, Molteni A, Martini V, Lunghi M, Fianchi L, Cilloni D, Lanza F, Abruzzese E, Cascavilla N, Rivellini F, Ferrara F, Maurillo L, Nanni J, Romano A, Cardinali V, Gigli F, Roncoroni E, Federico V, Marconi G, Volpi R, Sciumè M, Tarella C, Rossi G, and Martinelli G
Abstract: Background: Venetoclax in combination with hypomethylating agents (HMA) is revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large sets of patients is lacking, especially in relapsed or refractory leukemia. Methods: AVALON is a multicentric cohort study that was conducted in Italy on patients with AML who received venetoclax-based therapies from 2015 to 2020. The study was approved by the ethics committee of the participating institution and was conducted in accordance with the Declaration of Helsinki. The effectiveness and toxicity of venetoclax + HMA in 190 (43 newly diagnosed, 68 refractory, and 79 relapsed) patients with AML are reported here. Results: In the newly diagnosed AML, the overall response rate and survival confirmed the brilliant results demonstrated in VIALE-A. In the relapsed or refractory AML, the combination demonstrated a surprisingly complete remission rate (44.1% in refractory and 39.7% in relapsed evaluable patients) and conferred to treated patients a good expectation of survival. Toxicities were overall manageable, and most incidents occurred in the first 60 days of therapy. Infections were confirmed as the most common nonhematologic adverse event. Conclusions: Real-life data show that the combination of venetoclax and HMA offers an expectation of remission and long-term survival to elderly, newly diagnosed patients, and to relapsed or chemoresistant AML, increasing the chance of cure through a different mechanism of action. The venetoclax + HMA combination is expected to constitute the base for triplet combinations and integration of target therapies. Our data contribute to ameliorate the understanding of venetoclax + HMA effectiveness and toxicities in real life.
Published: 2023

20. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study

Author: Pham, T, Heunks, L, Bellani, G, Madotto, F, Aragao, I, Beduneau, G, Goligher, E, Grasselli, G, Laake, J, Mancebo, J, Penuelas, O, Piquilloud, L, Pesenti, A, Wunsch, H, van Haren, F, Brochard, L, Laffey, J, Abrough, F, Acharya, S, Amin, P, Arabi, Y, Bauer, P, Beitler, J, Berkius, J, Bugedo, G, Camporota, L, Cerny, V, Cho, Y, Clarkson, K, Estenssoro, E, Gritsan, A, Hashemian, S, Hermans, G, Jovanovic, B, Kurahashi, K, Matamis, D, Moerer, O, Molnar, Z, Ozyilmaz, E, Panka, B, Papali, A, Perbet, S, Qiu, H, Razek, A, Rittayamai, N, Roldan, R, Serpa Neto, A, Szuldrzynski, K, Talmor, D, Tomescu, D, Villagomez, A, Zeggwagh, A, Abe, T, Aboshady, A, Acampo-de Jong, M, Adderley, J, Adiguzel, N, Agrawal, V, Aguilar, G, Aguirre, G, Aguirre-Bermeo, H, Ahlstrom, B, Akbas, T, Akker, M, Al Sadeh, G, Alamri, S, Algaba, A, Ali, M, Aliberti, A, Allegue, J, Alvarez, D, Amador, J, Andersen, F, Ansari, S, Apichatbutr, Y, Apostolopoulou, O, Arellano, D, Arica, M, Arikan, H, Arinaga, K, Arnal, J, Asano, K, Asin-Corrochano, M, Avalos Cabrera, J, Avila Fuentes, S, Aydemir, S, Aygencel, G, Azevedo, L, Bacakoglu, F, Badie, J, Baedorf Kassis, E, Bai, G, Balaraj, G, Ballico, B, Banner-Goodspeed, V, Banwarie, P, Barbieri, R, Baronia, A, Barrett, J, Barrot, L, Barrueco-Francioni, J, Barry, J, Bawangade, H, Beavis, S, Beck, E, Beehre, N, Belenguer Muncharaz, A, Belliato, M, Bellissima, A, Beltramelli, R, Ben Souissi, A, Benitez-Cano, A, Benlamin, M, Benslama, A, Bento, L, Benvenuti, D, Bernabe, L, Bersten, A, Berta, G, Bertini, P, Bertram-Ralph, E, Besbes, M, Bettini, L, Beuret, P, Bewley, J, Bezzi, M, Bhakhtiani, L, Bhandary, R, Bhowmick, K, Bihari, S, Bissett, B, Blythe, D, Bocher, S, Boedjawan, N, Bojanowski, C, Boni, E, Boraso, S, Borelli, M, Borello, S, Borislavova, M, Bosma, K, Bottiroli, M, Boyd, O, Bozbay, S, Briva, A, Bruel, C, Bruni, A, Buehner, U, Bulpa, P, Burt, K, Buscot, M, Buttera, S, Cabrera, J, Caccese, R, Caironi, P, Canchos Gutierrez, I, Canedo, N, Cani, A, Cappellini, I, Carazo, J, Cardonnet, L, Carpio, D, Carriedo, D, Carrillo, R, Carvalho, J, Caser, E, Castelli, A, Castillo Quintero, M, Castro, H, Catorze, N, Cengiz, M, Cereijo, E, Ceunen, H, Chaintoutis, C, Chang, Y, Chaparro, G, Chapman, C, Chau, S, Chavez, C, Chelazzi, C, Chelly, J, Chemouni, F, Chen, K, Chena, A, Chiarandini, P, Chilton, P, Chiumello, D, Chou-Lie, Y, Chudeau, N, Cinel, I, Cinnella, G, Clark, M, Clark, T, Clementi, S, Coaguila, L, Codecido, A, Collins, A, Colombo, R, Conde, J, Consales, G, Cook, T, Coppadoro, A, Cornejo, R, Cortegiani, A, Coxo, C, Cracchiolo, A, Crespo Ramirez, M, Crova, P, Cruz, J, Cubattoli, L, Cukurova, Z, Curto, F, Czempik, P, D'Andrea, R, da Silva Ramos, F, Dangers, L, Danguy des Deserts, M, Danin, P, Dantas, F, Daubin, C, Dawei, W, de Haro, C, de Jesus Montelongo, F, De Mendoza, D, de Pablo, R, De Pascale, G, De Rosa, S, Decavele, M, Declercq, P, Deicas, A, del Carmen Campos Moreno, M, Dellamonica, J, Delmas, B, Demirkiran, O, Demirkiran, H, Dendane, T, di Mussi, R, Diakaki, C, Diaz, A, Diaz, W, Dikmen, Y, Dimoula, A, Doble, P, Doha, N, Domingos, G, Dres, M, Dries, D, Duggal, A, Duke, G, Dunts, P, Dybwik, K, Dykyy, M, Eckert, P, Efe, S, Elatrous, S, Elay, G, Elmaryul, A, Elsaadany, M, Elsayed, H, Elsayed, S, Emery, M, Ena, S, Eng, K, Englert, J, Erdogan, E, Ergin Ozcan, P, Eroglu, E, Escobar, M, Esen, F, Esen Tekeli, A, Esquivel, A, Esquivel Gallegos, H, Ezzouine, H, Facchini, A, Faheem, M, Fanelli, V, Farina, M, Fartoukh, M, Fehrle, L, Feng, F, Feng, Y, Fernandez, I, Fernandez, B, Fernandez-Rodriguez, M, Ferrando, C, Ferreira da Silva, M, Ferreruela, M, Ferrier, J, Flamm Zamorano, M, Flood, L, Floris, L, Fluckiger, M, Forteza, C, Fortunato, A, Frans, E, Frattari, A, Fredes, S, Frenzel, T, Fumagalli, R, Furche, M, Fusari, M, Fysh, E, Galeas-Lopez, J, Galerneau, L, Garcia, A, Garcia, M, Garcia, E, Garcia Olivares, P, Garlicki, J, Garnero, A, Garofalo, E, Gautam, P, Gazenkampf, A, Gelinotte, S, Gelormini, D, Ghrenassia, E, Giacomucci, A, Giannoni, R, Gigante, A, Glober, N, Gnesin, P, Gollo, Y, Gomaa, D, Gomero Paredes, R, Gomes, R, Gomez, R, Gomez, O, Gomez, A, Gondim, L, Gonzalez, M, Gonzalez, I, Gonzalez-Castro, A, Gordillo Romero, O, Gordo, F, Gouin, P, Graf Santos, J, Grainne, R, Grando, M, Granov Grabovica, S, Grasso, S, Grasso, R, Grimmer, L, Grissom, C, Gu, Q, Guan, X, Guarracino, F, Guasch, N, Guatteri, L, Gueret, R, Guerin, C, Guerot, E, Guitard, P, Gul, F, Gumus, A, Gurjar, M, Gutierrez, P, Hachimi, A, Hadzibegovic, A, Hagan, S, Hammel, C, Han Song, J, Hanlon, G, Heines, S, Henriksson, J, Herbrecht, J, Heredia Orbegoso, G, Hermon, A, Hernandez, R, Hernandez, C, Herrera, L, Herrera-Gutierrez, M, Hidalgo, J, Hill, D, Holmquist, D, Homez, M, Hongtao, X, Hormis, A, Horner, D, Hornos, M, Hou, M, House, S, Housni, B, Hugill, K, Humphreys, S, Humbert, L, Hunter, S, Hwa Young, L, Iezzi, N, Ilutovich, S, Inal, V, Innes, R, Ioannides, P, Iotti, G, Ippolito, M, Irie, H, Iriyama, H, Itagaki, T, Izura, J, Izza, S, Jabeen, R, Jamaati, H, Jamadarkhana, S, Jamoussi, A, Jankowski, M, Jaramillo, L, Jeon, K, Jeong Lee, S, Jeswani, D, Jha, S, Jiang, L, Jing, C, Jochmans, S, Johnstad, B, Jongmin, L, Joret, A, Junhasavasdikul, D, Jurado, M, Kam, E, Kamohara, H, Kane, C, Kara, I, Karakurt, S, Karnjanarachata, C, Kataoka, J, Katayama, S, Kaushik, S, Kelebek Girgin, N, Kerr, K, Kerslake, I, Khairnar, P, Khalid, A, Khan, A, Khanna, A, Khorasanee, R, Kienhorst, D, Kirakli, C, Knafelj, R, Kol, M, Kongpolprom, N, Kopitko, C, Korkmaz Ekren, P, Kubisz-Pudelko, A, Kulcsar, Z, Kumasawa, J, Kuriyama, A, Kutchak, F, Labarca, E, Labat, F, Laborda, C, Laca Barrera, M, Lagache, L, Landaverde Lopez, A, Lanspa, M, Lascari, V, Le Meur, M, Lee, S, Lee, Y, Lee, J, Lee, W, Legernaes, T, Leiner, T, Lemiale, V, Leonor, T, Lepper, P, Li, D, Li, H, Li, O, Lima, A, Lind, D, Litton, E, Liu, N, Liu, L, Liu, J, Llitjos, J, Llorente, B, Lopez, R, Lopez, C, Lopez Nava, C, Lovazzano, P, Lu, M, Lucchese, F, Lugano, M, Lugo Goytia, G, Luo, H, Lynch, C, Macheda, S, Madrigal Robles, V, Maggiore, S, Magret Iglesias, M, Malaga, P, Mallapura Maheswarappa, H, Malpartida, G, Malyarchikov, A, Mansson, H, Manzano, A, Marey, I, Marin, N, Marin, M, Markman, E, Martin, F, Martin, A, Martin Dal Gesso, C, Martinez, F, Martinez-Fidalgo, C, Martin-Loeches, I, Mas, A, Masaaki, S, Maseda, E, Massa, E, Mattsson, A, Maugeri, J, Mccredie, V, Mccullough, J, Mcguinness, S, Mckown, A, Medve, L, Mei, C, Mellado Artigas, R, Mendes, V, Mervat, M, Michaux, I, Mikhaeil, M, Milagros, O, Milet, I, Millan, M, Minwei, Z, Mirabella, L, Mishra, S, Mistraletti, G, Mochizuki, K, Moghal, A, Mojoli, F, Molin, A, Montiel, R, Montini, L, Monza, G, Mora Aznar, M, Morakul, S, Morales, M, Moreno Torres, D, Morocho Tutillo, D, Motherway, C, Mouhssine, D, Mouloudi, E, Munoz, T, Munoz de Cabo, C, Mustafa, M, Muthuchellappan, R, Muthukrishnan, M, Muttini, S, Nagata, I, Nahar, D, Nakanishi, M, Nakayama, I, Namendys-Silva, S, Nanchal, R, Nandakumar, S, Nasi, A, Nasir, K, Navalesi, P, Naz Aslam, T, Nga Phan, T, Nichol, A, Niiyama, S, Nikolakopoulou, S, Nikolic, E, Nitta, K, Noc, M, Nonas, S, Nseir, S, Nur Soyturk, A, Obata, Y, Oeckler, R, Oguchi, M, Ohshimo, S, Oikonomou, M, Ojados, A, Oliveira, M, Oliveira Filho, W, Oliveri, C, Olmos, A, Omura, K, Orlandi, M, Orsenigo, F, Ortiz-Ruiz De Gordoa, L, Ota, K, Ovalle Olmos, R, Oveges, N, Oziemski, P, Ozkan Kuscu, O, Pachas Alvarado, F, Pagella, G, Palaniswamy, V, Palazon Sanchez, E, Palmese, S, Pan, G, Pan, W, Papanikolaou, M, Papavasilopoulou, T, Parekh, A, Parke, R, Parrilla, F, Parrilla, D, Pasha, T, Pasin, L, Patao, L, Patel, M, Patel, G, Pati, B, Patil, J, Pattnaik, S, Paul, D, Pavesi, M, Pavlotsky, V, Paz, G, Paz, E, Pecci, E, Pellegrini, C, Pena Padilla, A, Perchiazzi, G, Pereira, T, Pereira, V, Perez, M, Perez Calvo, C, Perez Cheng, M, Perez Maita, R, Perez-Araos, R, Perez-Teran, P, Perez-Torres, D, Perkins, G, Persona, P, Petnak, T, Petrova, M, Philippart, F, Picetti, E, Pierucci, E, Piervincenzi, E, Pinciroli, R, Pintado, M, Piraino, T, Piras, S, Piras, C, Pirompanich, P, Pisani, L, Platas, E, Plotnikow, G, Porras, W, Porta, V, Portilla, M, Portugal, J, Povoa, P, Prat, G, Pratto, R, Preda, G, Prieto, I, Prol-Silva, E, Pugh, R, Qi, Y, Qian, C, Qin, T, Qu, H, Quintana, T, Quispe Sierra, R, Quispe Soto, R, Rabbani, R, Rabee, M, Rabie, A, Rahe Pereira, M, Rai, A, Raj Ashok, S, Rajab, M, Ramdhani, N, Ramey, E, Ranieri, M, Rathod, D, Ray, B, Redwanul Huq, S, Regli, A, Reina, R, Resano Sarmiento, N, Reynaud, F, Rialp, G, Ricart, P, Rice, T, Richardson, A, Rieder, M, Rinket, M, Rios, F, Risso Vazquez, A, Riva, I, Rivette, M, Roca, O, Roche-Campo, F, Rodriguez, C, Rodriguez, G, Rodriguez Gonzalez, D, Rodriguez Tucto, X, Rogers, A, Romano, M, Rortveit, L, Rose, A, Roux, D, Rouze, A, Rubatto Birri, P, Ruilan, W, Ruiz Robledo, A, Ruiz-Aguilar, A, Sadahiro, T, Saez, I, Sagardia, J, Saha, R, Saiphoklang, N, Saito, S, Salem, M, Sales, G, Salgado, P, Samavedam, S, Sami Mebazaa, M, Samuelsson, L, San Juan Roman, N, Sanchez, P, Sanchez-Ballesteros, J, Sandoval, Y, Sani, E, Santos, M, Santos, C, Sanui, M, Saravanabavan, L, Sari, S, Sarkany, A, Sauneuf, B, Savioli, M, Sazak, H, Scano, R, Schneider, F, Schortgen, F, Schultz, M, Schwarz, G, Seckin Yucesoy, F, Seely, A, Seiler, F, Seker Tekdos, Y, Seok Chan, K, Serano, L, Serednicki, W, Setten, M, Shah, A, Shah, B, Shang, Y, Shanmugasundaram, P, Shapovalov, K, Shebl, E, Shiga, T, Shime, N, Shin, P, Short, J, Shuhua, C, Siddiqui, S, Silesky Jimenez, J, Silva, D, Silva Sales, B, Simons, K, Sjobo, B, Slessor, D, Smiechowicz, J, Smischney, N, Smith, P, Smith, T, Smith, M, Snape, S, Snyman, L, Soetens, F, Sook Hong, K, Sosa Medellin, M, Soto, G, Souloy, X, Sousa, E, Sovatzis, S, Sozutek, D, Spadaro, S, Spagnoli, M, Spangfors, M, Spittle, N, Spivey, M, Stapleton, A, Stefanovic, B, Stephenson, L, Stevenson, E, Strand, K, Strano, M, Straus, S, Sun, C, Sun, R, Sundaram, V, Sunpark, T, Surlemont, E, Sutherasan, Y, Szabo, Z, Tainter, C, Takaba, A, Tallott, M, Tamasato, T, Tang, Z, Tangsujaritvijit, V, Taniguchi, L, Taniguchi, D, Tarantino, F, Teerapuncharoen, K, Temprano, S, Terragni, P, Terzi, N, Thakur, A, Theerawit, P, Thille, A, Thomas, M, Thungtitigul, P, Thyrault, M, Tilouch, N, Timenetsky, K, Tirapu, J, Todeschini, M, Tomas, R, Tomaszewski, C, Tonetti, T, Tonnelier, A, Trinder, J, Trongtrakul, K, Truwit, J, Tsuei, B, Tulaimat, A, Turan, S, Turkoglu, M, Tyagi, S, Ubeda, A, Vagginelli, F, Valenti, M, Vallverdu, I, Van Axel, A, van den Hul, I, van der Hoeven, H, Van Der Meer, N, Vanhoof, M, Vargas-Ordonez, M, Vaschetto, R, Vascotto, E, Vatsik, M, Vaz, A, Vazquez-Sanchez, A, Ventura, S, Vermeijden, J, Vidal, A, Vieira, J, Vilela Costa Pinto, B, Villagra, A, Villegas Succar, C, Vinorum, O, Vitale, G, Vj, R, Vochin, A, Voiriot, G, Volta, C, von Seth, M, Wajdi, M, Walsh, D, Wang, S, Wardi, G, Ween-Velken, N, Wei, B, Weller, D, Welsh, D, Welters, I, Wert, M, Whiteley, S, Wilby, E, Williams, E, Williams, K, Wilson, A, Wojtas, J, Won Huh, J, Wrathall, D, Wright, C, Wu, J, Xi, G, Xing, Z, Xu, H, Yamamoto, K, Yan, J, Yanez, J, Yang, X, Yates, E, Yazicioglu Mocin, O, Ye, Z, Yildirim, F, Yoshida, N, Yoshido, H, Young Lee, B, Yu, R, Yu, G, Yu, T, Yuan, B, Yuangtrakul, N, Yumoto, T, Yun, X, Zakalik, G, Zaki, A, Zalba-Etayo, B, Zambon, M, Zang, B, Zani, G, Zarka, J, Zerbi, S, Zerman, A, Zetterquist, H, Zhang, J, Zhang, H, Zhang, W, Zhang, G, Zhao, H, Zheng, J, Zhu, B, Zumaran, R, Pham T., Heunks L., Bellani G., Madotto F., Aragao I., Beduneau G., Goligher E. C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. H., Ansari S., Apichatbutr Y., Apostolopoulou O., Arellano D., Arica M., Arikan H., Arinaga K., Arnal J. -M., Asano K., Asin-Corrochano M., Avalos Cabrera J. M., Avila Fuentes S., Aydemir S., Aygencel G., Azevedo L., Bacakoglu F., Badie J., Baedorf Kassis E., Bai G., Balaraj G., Ballico B., Banner-Goodspeed V., Banwarie P., Barbieri R., Baronia A., Barrett J., Barrot L., Barrueco-Francioni J. E., Barry J., Bawangade H., Beavis S., Beck E., Beehre N., Belenguer Muncharaz A., Belliato M., Bellissima A., Beltramelli R., Ben Souissi A., Benitez-Cano A., Benlamin M., Benslama A., Bento L., Benvenuti D., Bernabe L., Bersten A., Berta G., Bertini P., Bertram-Ralph E., Besbes M., Bettini L. R., Beuret P., Bewley J., Bezzi M., Bhakhtiani L., Bhandary R., Bhowmick K., Bihari S., Bissett B., Blythe D., Bocher S., Boedjawan N., Bojanowski C. M., Boni E., Boraso S., Borelli M., Borello S., Borislavova M., Bosma K. J., Bottiroli M., Boyd O., Bozbay S., Briva A., Bruel C., Bruni A., Buehner U., Bulpa P., Burt K., Buscot M., Buttera S., Cabrera J., Caccese R., Caironi P., Canchos Gutierrez I., Canedo N., Cani A., Cappellini I., Carazo J., Cardonnet L. P., Carpio D., Carriedo D., Carrillo R., Carvalho J., Caser E., Castelli A., Castillo Quintero M., Castro H., Catorze N., Cengiz M., Cereijo E., Ceunen H., Chaintoutis C., Chang Y., Chaparro G., Chapman C., Chau S., Chavez C. E., Chelazzi C., Chelly J., Chemouni F., Chen K., Chena A., Chiarandini P., Chilton P., Chiumello D., Chou-Lie Y., Chudeau N., Cinel I., Cinnella G., Clark M., Clark T., Clementi S., Coaguila L., Codecido A. J., Collins A., Colombo R., Conde J., Consales G., Cook T., Coppadoro A., Cornejo R., Cortegiani A., Coxo C., Cracchiolo A. N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. 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M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. 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W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. 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C., Grasselli G., Laake J. H., Mancebo J., Penuelas O., Piquilloud L., Pesenti A., Wunsch H., van Haren F., Brochard L., Laffey J. G., Abrough F., Acharya S. P., Amin P., Arabi Y., Bauer P., Beitler J., Berkius J., Bugedo G., Camporota L., Cerny V., Cho Y. -J., Clarkson K., Estenssoro E., Goligher E., Gritsan A., Hashemian S. M., Hermans G., Heunks L. M., Jovanovic B., Kurahashi K., Matamis D., Moerer O., Molnar Z., Ozyilmaz E., Panka B., Papali A., Perbet S., Qiu H., Razek A. A., Rittayamai N., Roldan R., Serpa Neto A., Szuldrzynski K., Talmor D., Tomescu D., Villagomez A., Zeggwagh A. A., Abe T., Aboshady A., Acampo-de Jong M., Acharya S., Adderley J., Adiguzel N., Agrawal V. K., Aguilar G., Aguirre G., Aguirre-Bermeo H., Ahlstrom B., Akbas T., Akker M., Al Sadeh G., Alamri S., Algaba A., Ali M., Aliberti A., Allegue J. M., Alvarez D., Amador J., Andersen F. H., Ansari S., Apichatbutr Y., Apostolopoulou O., Arellano D., Arica M., Arikan H., Arinaga K., Arnal J. -M., Asano K., Asin-Corrochano M., Avalos Cabrera J. M., Avila Fuentes S., Aydemir S., Aygencel G., Azevedo L., Bacakoglu F., Badie J., Baedorf Kassis E., Bai G., Balaraj G., Ballico B., Banner-Goodspeed V., Banwarie P., Barbieri R., Baronia A., Barrett J., Barrot L., Barrueco-Francioni J. E., Barry J., Bawangade H., Beavis S., Beck E., Beehre N., Belenguer Muncharaz A., Belliato M., Bellissima A., Beltramelli R., Ben Souissi A., Benitez-Cano A., Benlamin M., Benslama A., Bento L., Benvenuti D., Bernabe L., Bersten A., Berta G., Bertini P., Bertram-Ralph E., Besbes M., Bettini L. R., Beuret P., Bewley J., Bezzi M., Bhakhtiani L., Bhandary R., Bhowmick K., Bihari S., Bissett B., Blythe D., Bocher S., Boedjawan N., Bojanowski C. M., Boni E., Boraso S., Borelli M., Borello S., Borislavova M., Bosma K. J., Bottiroli M., Boyd O., Bozbay S., Briva A., Bruel C., Bruni A., Buehner U., Bulpa P., Burt K., Buscot M., Buttera S., Cabrera J., Caccese R., Caironi P., Canchos Gutierrez I., Canedo N., Cani A., Cappellini I., Carazo J., Cardonnet L. P., Carpio D., Carriedo D., Carrillo R., Carvalho J., Caser E., Castelli A., Castillo Quintero M., Castro H., Catorze N., Cengiz M., Cereijo E., Ceunen H., Chaintoutis C., Chang Y., Chaparro G., Chapman C., Chau S., Chavez C. E., Chelazzi C., Chelly J., Chemouni F., Chen K., Chena A., Chiarandini P., Chilton P., Chiumello D., Chou-Lie Y., Chudeau N., Cinel I., Cinnella G., Clark M., Clark T., Clementi S., Coaguila L., Codecido A. J., Collins A., Colombo R., Conde J., Consales G., Cook T., Coppadoro A., Cornejo R., Cortegiani A., Coxo C., Cracchiolo A. N., Crespo Ramirez M., Crova P., Cruz J., Cubattoli L., Cukurova Z., Curto F., Czempik P., D'Andrea R., da Silva Ramos F., Dangers L., Danguy des Deserts M., Danin P. -E., Dantas F., Daubin C., Dawei W., de Haro C., de Jesus Montelongo F., De Mendoza D., de Pablo R., De Pascale G., De Rosa S., Decavele M., Declercq P. -L., Deicas A., del Carmen Campos Moreno M., Dellamonica J., Delmas B., Demirkiran O., Demirkiran H., Dendane T., di Mussi R., Diakaki C., Diaz A., Diaz W., Dikmen Y., Dimoula A., Doble P., Doha N., Domingos G., Dres M., Dries D., Duggal A., Duke G., Dunts P., Dybwik K., Dykyy M., Eckert P., Efe S., Elatrous S., Elay G., Elmaryul A. S., Elsaadany M., Elsayed H., Elsayed S., Emery M., Ena S., Eng K., Englert J. A., Erdogan E., Ergin Ozcan P., Eroglu E., Escobar M., Esen F., Esen Tekeli A., Esquivel A., Esquivel Gallegos H., Ezzouine H., Facchini A., Faheem M., Fanelli V., Farina M. F., Fartoukh M., Fehrle L., Feng F., Feng Y., Fernandez I., Fernandez B., Fernandez-Rodriguez M. L., Ferrando C., Ferreira da Silva M. J., Ferreruela M., Ferrier J., Flamm Zamorano M. J., Flood L., Floris L., Fluckiger M., Forteza C., Fortunato A., Frans E., Frattari A., Fredes S., Frenzel T., Fumagalli R., Furche M. A., Fusari M., Fysh E., Galeas-Lopez J. L., Galerneau L. -M., Garcia A., Garcia M. F., Garcia E., Garcia Olivares P., Garlicki J., Garnero A., Garofalo E., Gautam P., Gazenkampf A., Gelinotte S., Gelormini D., Ghrenassia E., Giacomucci A., Giannoni R., Gigante A., Glober N., Gnesin P., Gollo Y., Gomaa D., Gomero Paredes R., Gomes R., Gomez R. A., Gomez O., Gomez A., Gondim L., Gonzalez M., Gonzalez I., Gonzalez-Castro A., Gordillo Romero O., Gordo F., Gouin P., Graf Santos J., Grainne R., Grando M., Granov Grabovica S., Grasso S., Grasso R., Grimmer L., Grissom C., Gu Q., Guan X. -D., Guarracino F., Guasch N., Guatteri L., Gueret R., Guerin C., Guerot E., Guitard P. -G., Gul F., Gumus A., Gurjar M., Gutierrez P., Hachimi A., Hadzibegovic A., Hagan S., Hammel C., Han Song J., Hanlon G., Heines S., Henriksson J., Herbrecht J. -E., Heredia Orbegoso G. O., Hermon A., Hernandez R., Hernandez C., Herrera L., Herrera-Gutierrez M., Hidalgo J., Hill D., Holmquist D., Homez M., Hongtao X., Hormis A., Horner D., Hornos M. C., Hou M., House S., Housni B., Hugill K., Humphreys S., Humbert L., Hunter S., Hwa Young L., Iezzi N., Ilutovich S., Inal V., Innes R., Ioannides P., Iotti G. A., Ippolito M., Irie H., Iriyama H., Itagaki T., Izura J., Izza S., Jabeen R., Jamaati H., Jamadarkhana S., Jamoussi A., Jankowski M., Jaramillo L. A., Jeon K., Jeong Lee S., Jeswani D., Jha S., Jiang L., Jing C., Jochmans S., Johnstad B. A., Jongmin L., Joret A., Junhasavasdikul D., Jurado M. T., Kam E., Kamohara H., Kane C., Kara I., Karakurt S., Karnjanarachata C., Kataoka J., Katayama S., Kaushik S., Kelebek Girgin N., Kerr K., Kerslake I., Khairnar P., Khalid A., Khan A., Khanna A. K., Khorasanee R., Kienhorst D., Kirakli C., Knafelj R., Kol M. K., Kongpolprom N., Kopitko C., Korkmaz Ekren P., Kubisz-Pudelko A., Kulcsar Z., Kumasawa J., Kuriyama A., Kutchak F., Labarca E., Labat F., Laborda C., Laca Barrera M. A., Lagache L., Landaverde Lopez A., Lanspa M., Lascari V., Le Meur M., Lee S. H., Lee Y. J., Lee J., Lee W. -Y., Legernaes T., Leiner T., Lemiale V., Leonor T., Lepper P. M., Li D., Li H., Li O., Lima A. R., Lind D., Litton E., Liu N., Liu L., Liu J., Llitjos J. -F., Llorente B., Lopez R., Lopez C. E., Lopez Nava C., Lovazzano P., Lu M., Lucchese F., Lugano M., Lugo Goytia G., Luo H., Lynch C., Macheda S., Madrigal Robles V. H., Maggiore S. M., Magret Iglesias M., Malaga P., Mallapura Maheswarappa H., Malpartida G., Malyarchikov A., Mansson H., Manzano A., Marey I., Marin N., Marin M. D. C., Markman E., Martin F., Martin A., Martin Dal Gesso C., Martinez F., Martinez-Fidalgo C., Martin-Loeches I., Mas A., Masaaki S., Maseda E., Massa E., Mattsson A., Maugeri J., McCredie V., McCullough J., McGuinness S., McKown A., Medve L., Mei C., Mellado Artigas R., Mendes V., Mervat M. K. E., Michaux I., Mikhaeil M., Milagros O., Milet I., Millan M. T., Minwei Z., Mirabella L., Mishra S., Mistraletti G., Mochizuki K., Moghal A., Mojoli F., Molin A., Montiel R., Montini L., Monza G., Mora Aznar M., Morakul S., Morales M., Moreno Torres D., Morocho Tutillo D. R., Motherway C., Mouhssine D., Mouloudi E., Munoz T., Munoz de Cabo C., Mustafa M., Muthuchellappan R., Muthukrishnan M., Muttini S., Nagata I., Nahar D., Nakanishi M., Nakayama I., Namendys-Silva S. A., Nanchal R., Nandakumar S., Nasi A., Nasir K., Navalesi P., Naz Aslam T., Nga Phan T., Nichol A., Niiyama S., Nikolakopoulou S., Nikolic E., Nitta K., Noc M., Nonas S., Nseir S., Nur Soyturk A., Obata Y., Oeckler R., Oguchi M., Ohshimo S., Oikonomou M., Ojados A., Oliveira M. T., Oliveira Filho W., Oliveri C., Olmos A., Omura K., Orlandi M. C., Orsenigo F., Ortiz-Ruiz De Gordoa L., Ota K., Ovalle Olmos R., Oveges N., Oziemski P., Ozkan Kuscu O., Pachas Alvarado F., Pagella G., Palaniswamy V., Palazon Sanchez E. L., Palmese S., Pan G., Pan W., Papanikolaou M., Papavasilopoulou T., Parekh A., Parke R., Parrilla F. J., Parrilla D., Pasha T., Pasin L., Patao L., Patel M., Patel G., Pati B. K., Patil J., Pattnaik S., Paul D., Pavesi M., Pavlotsky V. A., Paz G., Paz E., Pecci E., Pellegrini C., Pena Padilla A. G., Perchiazzi G., Pereira T., Pereira V., Perez M., Perez Calvo C., Perez Cheng M., Perez Maita R., Perez-Araos R., Perez-Teran P., Perez-Torres D., Perkins G., Persona P., Petnak T., Petrova M., Philippart F., Picetti E., Pierucci E., Piervincenzi E., Pinciroli R., Pintado M. -C., Piraino T., Piras S., Piras C., Pirompanich P., Pisani L., Platas E., Plotnikow G., Porras W., Porta V., Portilla M., Portugal J., Povoa P., Prat G., Pratto R., Preda G., Prieto I., Prol-Silva E., Pugh R., Qi Y., Qian C., Qin T., Qu H., Quintana T., Quispe Sierra R., Quispe Soto R., Rabbani R., Rabee M., Rabie A., Rahe Pereira M. A., Rai A., Raj Ashok S., Rajab M., Ramdhani N., Ramey E., Ranieri M., Rathod D., Ray B., Redwanul Huq S. M., Regli A., Reina R., Resano Sarmiento N., Reynaud F., Rialp G., Ricart P., Rice T., Richardson A., Rieder M., Rinket M., Rios F., Risso Vazquez A., Riva I., Rivette M., Roca O., Roche-Campo F., Rodriguez C., Rodriguez G., Rodriguez Gonzalez D., Rodriguez Tucto X. Y., Rogers A., Romano M. E., Rortveit L., Rose A., Roux D., Rouze A., Rubatto Birri P. N., Ruilan W., Ruiz Robledo A., Ruiz-Aguilar A. L., Sadahiro T., Saez I., Sagardia J., Saha R., Saiphoklang N., Saito S., Salem M., Sales G., Salgado P., Samavedam S., Sami Mebazaa M., Samuelsson L., San Juan Roman N., Sanchez P., Sanchez-Ballesteros J., Sandoval Y., Sani E., Santos M., Santos C., Sanui M., Saravanabavan L., Sari S., Sarkany A., Sauneuf B., Savioli M., Sazak H., Scano R., Schneider F., Schortgen F., Schultz M. J., Schwarz G. L., Seckin Yucesoy F., Seely A., Seiler F., Seker Tekdos Y., Seok Chan K., Serano L., Serednicki W., Setten M., Shah A., Shah B., Shang Y., Shanmugasundaram P., Shapovalov K., Shebl E., Shiga T., Shime N., Shin P., Short J., Shuhua C., Siddiqui S., Silesky Jimenez J. I., Silva D., Silva Sales B., Simons K., Sjobo B. A., Slessor D., Smiechowicz J., Smischney N., Smith P., Smith T., Smith M., Snape S., Snyman L., Soetens F., Sook Hong K., Sosa Medellin M. A., Soto G., Souloy X., Sousa E., Sovatzis S., Sozutek D., Spadaro S., Spagnoli M., Spangfors M., Spittle N., Spivey M., Stapleton A., Stefanovic B., Stephenson L., Stevenson E., Strand K., Strano M. T., Straus S., Sun C., Sun R., Sundaram V., SunPark T., Surlemont E., Sutherasan Y., Szabo Z., Tainter C., Takaba A., Tallott M., Tamasato T., Tang Z., Tangsujaritvijit V., Taniguchi L., Taniguchi D., Tarantino F., Teerapuncharoen K., Temprano S., Terragni P., Terzi N., Thakur A., Theerawit P., Thille A. W., Thomas M., Thungtitigul P., Thyrault M., Tilouch N., Timenetsky K., Tirapu J., Todeschini M., Tomas R., Tomaszewski C., Tonetti T., Tonnelier A., Trinder J., Trongtrakul K., Truwit J., Tsuei B., Tulaimat A., Turan S., Turkoglu M., Tyagi S., Ubeda A., Vagginelli F., Valenti M. F., Vallverdu I., Van Axel A., van den Hul I., van der Hoeven H., Van Der Meer N., Vanhoof M., Vargas-Ordonez M., Vaschetto R., Vascotto E., Vatsik M., Vaz A., Vazquez-Sanchez A., Ventura S., Vermeijden J. W., Vidal A., Vieira J., Vilela Costa Pinto B., Villagra A., Villegas Succar C., Vinorum O. G., Vitale G., Vj R., Vochin A., Voiriot G., Volta C. A., von Seth M., Wajdi M., Walsh D., Wang S., Wardi G., Ween-Velken N. C., Wei B. -L., Weller D., Welsh D., Welters I., Wert M., Whiteley S., Wilby E., Williams E., Williams K., Wilson A., Wojtas J., Won Huh J., Wrathall D., Wright C., Wu J. -F., Xi G., Xing Z. -J., Xu H., Yamamoto K., Yan J., Yanez J., Yang X., Yates E., Yazicioglu Mocin O., Ye Z., Yildirim F., Yoshida N., Yoshido H. H. L., Young Lee B., Yu R., Yu G., Yu T., Yuan B., Yuangtrakul N., Yumoto T., Yun X., Zakalik G., Zaki A., Zalba-Etayo B., Zambon M., Zang B., Zani G., Zarka J., Zerbi S. M., Zerman A., Zetterquist H., Zhang J., Zhang H., Zhang W., Zhang G., Zhao H., Zheng J., Zhu B., and Zumaran R.
Abstract: Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 d
Published: 2023

21. Specific immunosuppressive role of nanodrugs targeting calcineurin in innate myeloid cells

Author: Colombo, M, Marongiu, L, Mingozzi, F, Marzi, R, Cigni, C, Facchini, F, Rotem, R, Valache, M, Stucchi, G, Rocca, G, Gornati, L, Rizzuto, M, Salvioni, L, Zanoni, I, Gori, A, Prosperi, D, Granucci, F, Colombo M., Marongiu L., Mingozzi F., Marzi R., Cigni C., Facchini F. A., Rotem R., Valache M., Stucchi G., Rocca G., Gornati L., Rizzuto M. A., Salvioni L., Zanoni I., Gori A., Prosperi D., Granucci F., Colombo, M, Marongiu, L, Mingozzi, F, Marzi, R, Cigni, C, Facchini, F, Rotem, R, Valache, M, Stucchi, G, Rocca, G, Gornati, L, Rizzuto, M, Salvioni, L, Zanoni, I, Gori, A, Prosperi, D, Granucci, F, Colombo M., Marongiu L., Mingozzi F., Marzi R., Cigni C., Facchini F. A., Rotem R., Valache M., Stucchi G., Rocca G., Gornati L., Rizzuto M. A., Salvioni L., Zanoni I., Gori A., Prosperi D., and Granucci F.
Abstract: Calcineurin (CN) inhibitors currently used to avoid transplant rejection block the activation of adaptive immune responses but also prevent the development of tolerance toward the graft, by directly inhibiting T cells. CN, through the transcription factors of the NFAT family, plays an important role also in the differentiation dendritic cells (DCs), the main cells responsible for the activation of T lymphocytes. Therefore, we hypothesized that the inhibition of CN only in DCs and not in T cells could be sufficient to prevent T cell responses, while allowing for the development of tolerance. Here, we show that inhibition of CN/NFAT pathway in innate myeloid cells, using a new nanoconjugate capable of selectively targeting phagocytes in vivo, protects against graft rejection and induces a longer graft acceptance compared to common CN inhibitors. We propose a new generation of nanoparticles-based selective immune suppressive agents for a better control of transplant acceptance.
Published: 2022

22. Maturation signatures of conventional dendritic cell subtypes in COVID-19 suggest direct viral sensing

Author: Marongiu, L, Protti, G, Facchini, F, Valache, M, Mingozzi, F, Ranzani, V, Putignano, A, Salviati, L, Bevilacqua, V, Curti, S, Crosti, M, Sarnicola, M, D'Angio, M, Bettini, L, Biondi, A, Nespoli, L, Tamini, N, Clementi, N, Mancini, N, Abrignani, S, Spreafico, R, Granucci, F, Marongiu L., Protti G., Facchini F. A., Valache M., Mingozzi F., Ranzani V., Putignano A. R., Salviati L., Bevilacqua V., Curti S., Crosti M., Sarnicola M. L., D'Angio M., Bettini L. R., Biondi A., Nespoli L., Tamini N., Clementi N., Mancini N., Abrignani S., Spreafico R., Granucci F., Marongiu, L, Protti, G, Facchini, F, Valache, M, Mingozzi, F, Ranzani, V, Putignano, A, Salviati, L, Bevilacqua, V, Curti, S, Crosti, M, Sarnicola, M, D'Angio, M, Bettini, L, Biondi, A, Nespoli, L, Tamini, N, Clementi, N, Mancini, N, Abrignani, S, Spreafico, R, Granucci, F, Marongiu L., Protti G., Facchini F. A., Valache M., Mingozzi F., Ranzani V., Putignano A. R., Salviati L., Bevilacqua V., Curti S., Crosti M., Sarnicola M. L., D'Angio M., Bettini L. R., Biondi A., Nespoli L., Tamini N., Clementi N., Mancini N., Abrignani S., Spreafico R., and Granucci F.
Abstract: Growing evidence suggests that conventional dendritic cells (cDCs) undergo aberrant maturation in COVID-19, which negatively affects T-cell activation. The presence of effector T cells in patients with mild disease and dysfunctional T cells in severely ill patients suggests that adequate T-cell responses limit disease severity. Understanding how cDCs cope with SARS-CoV-2 can help elucidate how protective immune responses are generated. Here, we report that cDC2 subtypes exhibit similar infection-induced gene signatures, with the upregulation of IFN-stimulated genes and IL-6 signaling pathways. Furthermore, comparison of cDCs between patients with severe and mild disease showed severely ill patients to exhibit profound downregulation of genes encoding molecules involved in antigen presentation, such as MHCII, TAP, and costimulatory proteins, whereas we observed the opposite for proinflammatory molecules, such as complement and coagulation factors. Thus, as disease severity increases, cDC2s exhibit enhanced inflammatory properties and lose antigen presentation capacity. Moreover, DC3s showed upregulation of anti-apoptotic genes and accumulated during infection. Direct exposure of cDC2s to the virus in vitro recapitulated the activation profile observed in vivo. Our findings suggest that SARS-CoV-2 interacts directly with cDC2s and implements an efficient immune escape mechanism that correlates with disease severity by downregulating crucial molecules required for T-cell activation.
Published: 2022

23. Lung Ultrasound in Patients With SARS-COV-2 Pneumonia: Correlations With Chest Computed Tomography, Respiratory Impairment, and Inflammatory Cascade

Author: Fratianni, G, Malfatto, G, Perger, E, Facchetti, L, Pini, L, Bosco, M, Cernigliaro, F, Perego, G, Facchini, M, Badano, L, Parati, G, Fratianni G., Malfatto G., Perger E., Facchetti L., Pini L., Bosco M., Cernigliaro F., Perego G. B., Facchini M., Badano L., Parati G., Fratianni, G, Malfatto, G, Perger, E, Facchetti, L, Pini, L, Bosco, M, Cernigliaro, F, Perego, G, Facchini, M, Badano, L, Parati, G, Fratianni G., Malfatto G., Perger E., Facchetti L., Pini L., Bosco M., Cernigliaro F., Perego G. B., Facchini M., Badano L., and Parati G.
Abstract: Objectives: Lung ultrasound (LUS) might be comparable to chest computed tomography (CT) in detecting parenchymal and pleural pathology, and in monitoring interstitial lung disease. We aimed to describe LUS characteristics of patients during the hospitalization for COVID-19 pneumonia, and to compare the extent of lung involvement at LUS and chest-CT with inflammatory response and the severity of respiration impairment. Methods: During a 2-week period, we performed LUS and chest CT in hospitalized patients affected by COVID-19 pneumonia. Dosages of high sensitivity C-reactive protein (HS-CRP), d-dimer, and interleukin-6 (IL-6) were also obtained. The index of lung function (P/F ratio) was calculated from the blood gas test. LUS and CT scoring were assessed using previously validated scores. Results: Twenty-six consecutive patients (3 women) underwent LUS 34 ± 14 days from the early symptoms. Among them, 21 underwent CT on the same day of LUS. A fair association was found between LUS and CT scores (R = 0.45, P =.049), which became stronger if the B-lines score on LUS was not considered (R = 0.57, P =.024). LUS B-lines score correlated with IL-6 levels (R = 0.75, P =.011), and the number of involved lung segments detected by LUS correlated with the P/F ratio (R = 0.60, P =.019) but not with HS-CRP and d-Dimer levels. No correlations were found between CT scores and inflammations markers or P/F. Conclusion: In patients with COVID-19 pneumonia, LUS was correlated with both the extent of the inflammatory response and the P/F ratio.
Published: 2022

24. Da “onda rosa” à “maré azul”: : crise e mudança no sistema partidário uruguaio (2005-2019)

Author: de Freixo, Adriano, da Silva, Allana Facchini, de Freixo, Adriano, and da Silva, Allana Facchini
Abstract: In this article, we propose to analyze the transformations that occurred in Uruguay’s party system between 2005 and 2019, placing them within the Latin American context of the rise and decline of the so-called “pink wave” and the subsequent outline of a “blue tide”. Thus, we seek to understand the conditions under which the decline of traditional uruguayan political parties took place; the growth, the electoral victories and the cycle of governments of the Frente Amplio; the rearticulation and renewal of the traditional right and; the emergence and strengthening of a new far-right party, the Cabildo Abierto. Finally, we seek to discuss and problematize the need to update the theoretical debate on the Uruguayan party system, in view of the greater fragmentation resulting from the 2019 elections., Neste artigo, nos propomos a analisar as transformações ocorridas no sistema partidário uruguaio entre 2005 e 2019, situando-as dentro do contexto latino-americano de ascensão e declínio da chamada “onda rosa” e do posterior esboço de uma “maré azul”. Assim, buscamos entender as condições nas quais se deram o declínio dos partidos políticos uruguaios tradicionais; o crescimento, as vitórias eleitorais e o ciclo de governos da Frente Ampla; a rearticulação e renovação da direita tradicional e; o surgimento e fortalecimento de um novo partido de extrema-direita, o Cabildo Abierto. Finalmente, procuramos discutir e problematizar a necessidade de atualização do debate teórico sobre o sistema partidário uruguaio, tendo em vista o quadro de maior fragmentação decorrente das eleições de 2019.
Published: 2023

25. Le novità legislative in materia di diritto di asilo in Italia nel 2023

Author: Bolzoni, M, Bonetti, P, Ciurlo, A, Düsch-Wehr, K, Efficace, S, Facchini, D, Godio, G, Ciriano, E, J, G, Hasnain, S, Iannaccone, A, Kibeida, Y, Marchetti, C, Micallef, R, M, Milani, J, Molfetta, M, Pagnotta,I, Rossi, M, Schiavone, G, Sozzi, M, Stege, U, Bolzoni, M, Bonetti, P, Ciurlo, A, Düsch-Wehr, K, Efficace, S, Facchini, D, Godio, G, Ciriano, E, J, G, Hasnain, S, Iannaccone, A, Kibeida, Y, Marchetti, C, Micallef, R, M, Milani, J, Molfetta, M, Pagnotta,I, Rossi, M, Schiavone, G, Sozzi, M, and Stege, U
Published: 2023

26. Protoplanetary disks in $K_s$-band total intensity and polarized light

Author: Ren, Bin B., Benisty, Myriam, Ginski, Christian, Tazaki, Ryo, Wallack, Nicole L., Milli, Julien, Garufi, Antonio, Bae, Jaehan, Facchini, Stefano, Ménard, François, Pinilla, Paola, Swastik, C., Teague, Richard, Wahhaj, Zahed, Ren, Bin B., Benisty, Myriam, Ginski, Christian, Tazaki, Ryo, Wallack, Nicole L., Milli, Julien, Garufi, Antonio, Bae, Jaehan, Facchini, Stefano, Ménard, François, Pinilla, Paola, Swastik, C., Teague, Richard, and Wahhaj, Zahed
Abstract: Diverse protoplanetary disk morphology can result from planet-disk interaction, suggesting planetary presence. To date, most scattered light imaging campaigns have probed polarized light, which is only a fraction of the total light and not very sensitive to planets. To observe and characterize protoplanetary disk systems in the near-infrared in both polarized and total intensity light, we carried out an unprecedented study of scattering properties of disks, as well as of any planetary companions. Using SPHERE with star-hopping at the Very Large Telescope, we observed 29 disk hosts and their reference stars in $K_s$-band polarized light. We extracted disks in total intensity by adopting the data imputation concept with sequential non-negative matrix factorization (DI-sNMF). We obtained high-quality disk images in total intensity for 15 systems and in polarized light for 23. For well-recovered disks in polarized light and total intensity, we parameterized the polarization fraction phase functions using scaled beta distribution: the peak of polarization fraction tentatively correlates with the peak scattering angle, which could be reproduced using certain compact dust, yet more detailed modeling studies are needed. We investigated the empirical DI-sNMF detectability of disks using logistic regression: total intensity detectability of disks primarily depends on host star brightness. For disks with SPHERE data in $Y$-/$J$-/$H$-band, we summarized their polarized color at ~90 deg scattering angle: most of disks are blue in polarized $J-K_s$ color, and they are relatively redder as stellar luminosity increases, indicating larger scatterers. High-quality disk imagery in both total intensity and polarized light thus allows for disk characterization in polarization fraction, and reduces the confusion between disk and planetary signals., Comment: 25 pages, 16 figures, 3 tables, A&A accepted. Data files in FITS format will be publicly available
Published: 2023
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27. Protoplanetary Disk Chemistry

Author: Öberg, Karin I., Facchini, Stefano, Anderson, Dana E., Öberg, Karin I., Facchini, Stefano, and Anderson, Dana E.
Abstract: Planets form in disks of gas and dust around young stars. The disk molecular reservoirs and their chemical evolution affect all aspects of planet formation, from the coagulation of dust grains into pebbles, to the elemental and molecular compositions of the mature planet. Disk chemistry also enables unique probes of disk structures and dynamics, including those directly linked to ongoing planet formation. Here we review the protoplanetary disk chemistry of the volatile elements HOCNSP, the associated observational and theoretical methods, and the links between disk and planet chemical compositions. Three takeaways from this review are: (1) The disk chemical composition, including the organic reservoirs, is set by both inheritance and in situ chemistry. (2) Disk gas and solid O/C/N/H elemental ratios often deviate from stellar values due to a combination of condensation of molecular carriers, chemistry, and dynamics. (3) Chemical, physical, and dynamical processes in disks are closely linked, which complicates disk chemistry modeling, but these links also present an opportunity to develop chemical probes of different aspects of disk evolution and planet formation., Comment: Invited review published in Annual Reviews of Astronomy and Astrophysics; 44 pages, 12 figures
Published: 2023
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28. Testing external photoevaporation in the $\sigma$-Orionis cluster with spectroscopy and disk mass measurements

Author: Maucó, K., Manara, C. F., Ansdell, M., Bettoni, G., Claes, R., Alcala, J., Miotello, A., Facchini, S., Haworth, T. J., Lodato, G., Williams, J. P., Maucó, K., Manara, C. F., Ansdell, M., Bettoni, G., Claes, R., Alcala, J., Miotello, A., Facchini, S., Haworth, T. J., Lodato, G., and Williams, J. P.
Abstract: The evolution of protoplanetary disks is regulated by an interplay of several processes, either internal to the system or related to the environment. As most of the stars and planets have formed in massive stellar clusters, studying the effects of UV radiation on disk evolution is of paramount importance. Here we test the impact of external photoevaporation on the evolution of disks in the $\sigma$ Orionis cluster by conducting the first combined large-scale UV to IR spectroscopic and mm-continuum survey of this region. We study a sample of 50 targets located at increasing distances from the central, OB system $\sigma$ Ori. We combine new VLT/X-Shooter spectra with new and previously published ALMA measurements of disk dust and gas fluxes and masses. We confirm the previously found decrease of $M_{\rm dust}$ in the inner $\sim$0.5 pc of the cluster. This is particularly evident when considering the disks around the more massive stars ($\ge$ 0.4 $M_{\odot}$), where those located in the inner part ($<$ 0.5 pc) have $M_{\rm dust}$ about an order of magnitude lower than the more distant ones. About half of the sample is located in the region of the $\dot{M}_{\rm acc}$ vs $M_{\rm disk}$ expected by models of external photoevaporation, namely showing shorter disk lifetimes. These are observed for all targets with projected separation from $\sigma$ Ori $<$ 0.5 pc, proving that the presence of a massive stellar system affects disk evolution. External photoevaporation is a viable mechanism to explain the observed shorter disk lifetimes and lower $M_{\rm dust}$ in the inner $\sim$0.5 pc of the cluster. Follow-up observations of the low stellar mass targets are crucial to confirm the dependence of the external photoevaporation process with stellar host mass. This work confirms that the effects of external photoevaporation are significant down to impinging radiation as low as $\sim 10^{4}$ G$_0$., Comment: Accepted for publication on Astronomy & Astrophysics. 13 pages, 7 figures + appendix. Abstract abridged to meet arXiv requirements
Published: 2023
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29. A magnetically driven disc wind in the inner disc of PDS 70

Author: Campbell-White, Justyn, Manara, Carlo F., Benisty, Myriam, Natta, Antonella, Claes, Rik A. B., Frasca, Antonio, Bae, Jaehan, Facchini, Stefano, Isella, Andrea, Pérez, Laura, Pinilla, Paola, Sicilia-Aguilar, Aurora, Teague, Richard, Campbell-White, Justyn, Manara, Carlo F., Benisty, Myriam, Natta, Antonella, Claes, Rik A. B., Frasca, Antonio, Bae, Jaehan, Facchini, Stefano, Isella, Andrea, Pérez, Laura, Pinilla, Paola, Sicilia-Aguilar, Aurora, and Teague, Richard
Abstract: PDS 70 is so far the only young disc where multiple planets have been detected by direct imaging. The disc has a large cavity when seen at sub-mm and NIR wavelengths, which hosts two massive planets. This makes PDS 70 the ideal target to study the physical conditions in a strongly depleted inner disc shaped by two giant planets, and in particular to test whether disc winds can play a significant role in its evolution. Using X-Shooter and HARPS spectra, we detected for the first time the wind-tracing [O I] 6300AA line, and confirm the low-moderate value of mass-accretion rate in the literature. The [O I] line luminosity is high with respect to the accretion luminosity when compared to a large sample of discs with cavities in nearby star-forming regions. The FWHM and blue-shifted peak of the [O I] line suggest an emission in a region very close to the star, favouring a magnetically driven wind as the origin. We also detect wind emission and high variability in the He I 10830AA line, which is unusual for low-accretors. We discuss that, although the cavity of PDS 70 was clearly carved out by the giant planets, the substantial inner disc wind could also have had a significant contribution to clearing the inner-disc., Comment: 13 pages, 7 figures, accepted for publication in ApJ
Published: 2023

30. MagAO-X and HST high-contrast imaging of the AS209 disk at H$\alpha$

Author: Cugno, Gabriele, Zhou, Yifan, Thanathibodee, Thanawuth, Calissendorff, Per, Meyer, Michael R., Edwards, Suzan, Bae, Jaehan, Benisty, Myriam, Bergin, Edwin, De Furio, Matthew, Facchini, Stefano, Males, Jared R., Close, Laird M., Teague, Richard D., Guyon, Olivier, Haffert, Sebastiaan Y., Hedglen, Alexander D., Kautz, Maggie, Izquierdo, Andrés, Long, Joseph D., Lumbres, Jennifer, McLeod, Avalon L., Pearce, Logan A., Schatz, Lauren, Van Gorkom, Kyle, Cugno, Gabriele, Zhou, Yifan, Thanathibodee, Thanawuth, Calissendorff, Per, Meyer, Michael R., Edwards, Suzan, Bae, Jaehan, Benisty, Myriam, Bergin, Edwin, De Furio, Matthew, Facchini, Stefano, Males, Jared R., Close, Laird M., Teague, Richard D., Guyon, Olivier, Haffert, Sebastiaan Y., Hedglen, Alexander D., Kautz, Maggie, Izquierdo, Andrés, Long, Joseph D., Lumbres, Jennifer, McLeod, Avalon L., Pearce, Logan A., Schatz, Lauren, and Van Gorkom, Kyle
Abstract: The detection of emission lines associated with accretion processes is a direct method for studying how and where gas giant planets form, how young planets interact with their natal protoplanetary disk and how volatile delivery to their atmosphere takes place. H$\alpha$ ($\lambda=0.656\,\mu$m) is expected to be the strongest accretion line observable from the ground with adaptive optics systems, and is therefore the target of specific high-contrast imaging campaigns. We present MagAO-X and HST data obtained to search for H$\alpha$ emission from the previously detected protoplanet candidate orbiting AS209, identified through ALMA observations. No signal was detected at the location of the candidate, and we provide limits on its accretion. Our data would have detected an H$\alpha$ emission with $F_\mathrm{H\alpha}>2.5\pm0.3 \times10^{-16}$ erg s$^{-1}$ cm$^{-2}$, a factor 6.5 lower than the HST flux measured for PDS70b (Zhou et al., 2021). The flux limit indicates that if the protoplanet is currently accreting it is likely that local extinction from circumstellar and circumplanetary material strongly attenuates its emission at optical wavelengths. In addition, the data reveal the first image of the jet north of the star as expected from previous detections of forbidden lines. Finally, this work demonstrates that current ground-based observations with extreme adaptive optics systems can be more sensitive than space-based observations, paving the way to the hunt for small planets in reflected light with extremely large telescopes., Comment: 13 pages, 5 figures, accepted for publication in AJ
Published: 2023

31. Tentative co-orbital submillimeter emission within the Lagrangian region L5 of the protoplanet PDS 70 b

Author: Balsalobre-Ruza, Olga, de Gregorio-Monsalvo, Itziar, Lillo-Box, Jorge, Huélamo, Nuria, Ribas, Álvaro, Benisty, Myriam, Bae, Jaehan, Facchini, Stefano, Teague, Richard, Balsalobre-Ruza, Olga, de Gregorio-Monsalvo, Itziar, Lillo-Box, Jorge, Huélamo, Nuria, Ribas, Álvaro, Benisty, Myriam, Bae, Jaehan, Facchini, Stefano, and Teague, Richard
Abstract: Context: High-spatial resolution Atacama Large Millimeter/submillimeter Array (ALMA) data have revealed a plethora of substructures in protoplanetary disks. Some of those features are thought to trace the formation of embedded planets. One example is the gas and dust that accumulated in the co-orbital Lagrangian regions $L_4$/$L_5$, which were tentatively detected in recent years and might be the pristine material for the formation of Trojan bodies. Aims: This work is part of the TROY project, whose ultimate goal is to find robust evidence of exotrojan bodies and study their implications in the exoplanet field. Here, we focus on the early stages of the formation of these bodies by inspecting the iconic system PDS 70, the only confirmed planetary system in formation. Methods: We reanalyzed archival high-angular resolution Band 7 ALMA observations from PDS 70 by doing an independent imaging process to look for emission in the Lagrangian regions of the two detected gas giant protoplanets, PDS 70 b and c. We then projected the orbital paths and visually inspected emission features at the regions around the $L_4$/$L_5$ locations as defined by $\pm$ 60$^{\circ}$ in azimuth from the planet position. Results: We found emission at a $\sim$4-$\sigma$ level ($\sim$6-$\sigma$ when correcting from a cleaning effect) at the position of the $L_{5}$ region of PDS 70 b. This emission corresponds to a dust mass in a range of 0.03- 2 M$_{Moon}$, which potentially accumulated in this gravitational well. Conclusions: The tentative detection of the co-orbital dust trap that we report requires additional observations to be confirmed. We predict that we could detect the co-orbital motion of PDS 70 b and the dust presumably associated with $L_5$ by observing again with the same sensitivity and angular resolution as early as February 2026., Comment: 8 pages, 5 figures, 2 tables. Published in Astronomy & Astrophysics
Published: 2023
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32. Radio multiwavelength analysis of the compact disk CX Tau: Presence of strong free-free variability or anomalous microwave emission

Author: Curone, Pietro, Testi, Leonardo, Macias, Enrique, Tazzari, Marco, Facchini, Stefano, Williams, Jonathan P., Clarke, Cathie J., Natta, Antonella, Rosotti, Giovanni, Toci, Claudia, Lodato, Giuseppe, Curone, Pietro, Testi, Leonardo, Macias, Enrique, Tazzari, Marco, Facchini, Stefano, Williams, Jonathan P., Clarke, Cathie J., Natta, Antonella, Rosotti, Giovanni, Toci, Claudia, and Lodato, Giuseppe
Abstract: Protoplanetary disks emit radiation across a broad range of wavelengths, requiring a multiwavelength approach to fully understand their physical mechanisms and how they form planets. Observations at sub-millimeter to centimeter wavelengths can provide insights into the thermal emission from dust, free-free emission from ionized gas, and possible gyro-synchrotron emission from the stellar magnetosphere. This work is focused on CX Tau, a ${\sim}0.4\,M_\odot$ star with an extended gas emission and a compact and apparently structureless dust disk, with an average millimeter flux when compared to Class II sources in Taurus. We present observations from the Karl G. Jansky Very Large Array (VLA) across four bands (between 9.0 mm and 6.0 cm) and combine them with archival data from the Atacama Large Millimeter/submillimeter Array (ALMA), the Submillimeter Array (SMA) and the Plateau de Bure Interferometer (PdBI). This multiwavelength approach allows us to separate the dust continuum from other emissions. After isolating the dust thermal emission, we derived an upper limit of the dust disk extent at 1.3 cm which is consistent with theoretical predictions of a radial drift-dominated disk. Centimeter data show a peculiar behavior: deep observations at 6.0 cm did not detect the source, while at 1.3 cm the flux density is anomalously higher than adjacent bands. Intraband spectral indices suggest a dominant contribution from free-free emission, whereas gyro-synchrotron emission is excluded. To explain these observations, we propose a strong variability among the free-free emission with timescales shorter than a month. Another possible interpretation is the presence of anomalous microwave emission from spinning dust grains., Comment: Accepted for publication in A&A; 13 pages, 13 figures, 1 table
Published: 2023
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33. Constraining the gas distribution in the PDS 70 disk as a method to assess the effect of planet-disk interactions

Author: Portilla-Revelo, B., Kamp, I., Facchini, S., van Dishoeck, E. F., Law, C., Rab, Ch., Bae, J., Benisty, M., Öberg, K., Teague, R., Portilla-Revelo, B., Kamp, I., Facchini, S., van Dishoeck, E. F., Law, C., Rab, Ch., Bae, J., Benisty, M., Öberg, K., and Teague, R.
Abstract: Embedded planets are potentially the cause of substructures like gaps and cavities observed in several protoplanetary disks. Thus, the substructures observed in the continuum and in line emission encode information about the presence of planets in the system and how they interact with the natal disk. The pre-transitional disk around the star PDS 70 is the first case of two young planets imaged within a dust depleted gap that was likely carved by themselves. We aim to determine the spatial distribution of the gas and dust components in the PDS 70 disk. The axisymmetric substructures observed in the resulting profiles are interpreted in the context of planet-disk interactions. We develop a thermo-chemical forward model for an axisymmetric disk to explain a subset of the Atacama Large Millimeter/Submillimeter Array (ALMA) band 6 observations of three CO isotopologues plus the continuum towards PDS 70. Combining the inferred gas and dust distributions, the model results in a variable gas-to-dust ratio profile throughout the disk that spans two orders of magnitude within the first $130$ au and shows a step gradient towards the outer disk, which is consistent with the presence of a pressure maxima driven by planet-disk interactions. We find a gas density drop factor of ${\sim} 19$ at the location of the planet PDS 70 c with respect to the peak gas density at $75$ au. Combining this value with literature results on the hydrodynamics of planet-disk interactions, we find this gas gap depth to be consistent with independent planet mass estimates from infrared observations. Our findings point towards gas stirring processes taking place in the common gap due to the gravitational perturbation of both planets., Comment: Accepted for publication in A&A
Published: 2023
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34. Molecules with ALMA at Planet-forming Scales (MAPS). Complex Kinematics in the AS 209 Disk Induced by a Forming Planet and Disk Winds

Author: Galloway-Sprietsma, Maria, Bae, Jaehan, Teague, Richard, Benisty, Myriam, Facchini, Stefano, Aikawa, Yuri, Alarcón, Felipe, Andrews, Sean M., Bergin, Edwin, Cataldi, Gianni, Cleeves, L. Ilsedore, Czekala, Ian, Guzmán, Viviana V., Huang, Jane, Law, Charles J., Gal, Romane Le, Liu, Yao, Long, Feng, Ménard, François, Öberg, Karin I., Walsh, Catherine, Wilner, David J., Galloway-Sprietsma, Maria, Bae, Jaehan, Teague, Richard, Benisty, Myriam, Facchini, Stefano, Aikawa, Yuri, Alarcón, Felipe, Andrews, Sean M., Bergin, Edwin, Cataldi, Gianni, Cleeves, L. Ilsedore, Czekala, Ian, Guzmán, Viviana V., Huang, Jane, Law, Charles J., Gal, Romane Le, Liu, Yao, Long, Feng, Ménard, François, Öberg, Karin I., Walsh, Catherine, and Wilner, David J.
Abstract: We study the kinematics of the AS 209 disk using the J=2-1 transitions of $^{12}$CO, $^{13}$CO, and C$^{18}$O. We derive the radial, azimuthal, and vertical velocity of the gas, taking into account the lowered emission surface near the annular gap at ~1.7 (200 au) within which a candidate circumplanetary disk-hosting planet has been reported previously. In $^{12}$CO and $^{13}$CO, we find a coherent upward flow arising from the gap. The upward gas flow is as fast as $150~{\rm m~s}^{-1}$ in the regions traced by $^{12}$CO emission, which corresponds to about 50% of the local sound speed or $6\%$ of the local Keplerian speed. Such an upward gas flow is difficult to reconcile with an embedded planet alone. Instead, we propose that magnetically driven winds via ambipolar diffusion are triggered by the low gas density within the planet-carved gap, dominating the kinematics of the gap region. We estimate the ambipolar Elsasser number, Am, using the HCO$^+$ column density as a proxy for ion density and find that Am is ~0.1 at the radial location of the upward flow. This value is broadly consistent with the value at which numerical simulations find ambipolar diffusion drives strong winds. We hypothesize the activation of magnetically-driven winds in a planet-carved gap can control the growth of the embedded planet. We provide a scaling relationship which describes the wind-regulated terminal mass: adopting parameters relevant to 100 au from a solar-mass star, we find the wind-regulated terminal mass is about one Jupiter mass, which may help explain the dearth of directly imaged super-Jovian-mass planets., Comment: This paper has been accepted for publication in the Astrophysical Journal (ApJ)
Published: 2023
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35. The Disc Miner II: Revealing Gas substructures and Kinematic signatures from Planet-disc interaction through line profile analysis

Author: Izquierdo, Andres F., Testi, Leonardo, Facchini, Stefano, Rosotti, Giovanni P., van Dishoeck, Ewine, Wölfer, Lisa, Paneque-Carreño, Teresa, Izquierdo, Andres F., Testi, Leonardo, Facchini, Stefano, Rosotti, Giovanni P., van Dishoeck, Ewine, Wölfer, Lisa, and Paneque-Carreño, Teresa
Abstract: [Abridged] The aim of this work is to identify potential signatures from planet-disc interaction in the circumstellar discs around MWC 480, HD 163296, AS 209, IM Lup, and GM Aur, through the study of molecular lines observed as part of the ALMA large program MAPS. Extended and localised perturbations in velocity, line width, and intensity have been analysed jointly using the DISCMINER modelling framework, in three bright CO lines, 12CO, 13CO, and C18O $J=2-1$, to provide a comprehensive summary of the kinematic and column density substructures that planets might be actively sculpting in these discs. We find convincing evidence for the presence of four giant planets located at wide orbits in three of the discs in the sample: two around HD 163296, one in MWC 480, and one in AS 209. One of the planet candidates in HD 163296, P94, previously associated with velocity signatures detected in lower velocity resolution 12CO data, is confirmed and linked to localised velocity and line width perturbations in 13CO and C18O too. We highlight that line widths are also powerful tracers of planet-forming sites as they are sensitive to turbulent motions triggered by planet-disc interactions. In MWC 480, we identified non-axisymmetric line width enhancements around the radial separation of candidate planet-driven buoyancy spirals, which we used to narrow the location of the possible planet to an orbital radius of $R=245$ au and $\rm{PA}=193^\circ$. In the disc of AS 209, we found excess 12CO line widths centred at $R=210$ au, $\rm{PA}=151^\circ$, spanning around the immediate vicinity of a circumplanetary disc candidate proposed previously, which further supports its presence. Our simultaneous analysis of multiple tracers and observables aims to lay the groundwork for robust studies of molecular line properties focused on the search for young planets in discs., Comment: Accepted for publication in A&A
Published: 2023
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36. Testing protoplanetary disc evolution with CO fluxes. A proof of concept in Lupus and Upper Sco

Author: Zagaria, Francesco, Facchini, Stefano, Miotello, Anna, Manara, Carlo F., Toci, Claudia, Clarke, Cathie J., Zagaria, Francesco, Facchini, Stefano, Miotello, Anna, Manara, Carlo F., Toci, Claudia, and Clarke, Cathie J.
Abstract: The Atacama Large Millimeter/submillimeter Array (ALMA) revolutionised our understanding of protoplanetary discs. However, the available data have not given conclusive answers yet on the underlying disc evolution mechanisms (viscosity or MHD winds). Improving upon the current results, mostly based on the analysis of disc sizes, is difficult because larger, deeper and higher angular resolution surveys would be required, which could be prohibitive even for ALMA. In this Letter, we introduce an alternative method to study disc evolution based on $^{12}$CO fluxes. In fact, fluxes can be readily collected using less time-consuming, lower resolution observations, while tracing the same disc physico-chemical processes as sizes: assuming that $^{12}$CO is optically thick, fluxes scale with the disc surface area. We developed a semi-analytical model to compute $^{12}$CO fluxes and benchmarked it against the results of DALI thermochemical models, recovering an agreement within a factor of three. As a proof of concept we compared our models with Lupus and Upper Sco data, taking advantage of the increased samples, by a factor 1.3 (Lupus) and 3.6 (Upper Sco), when studying fluxes instead of sizes. Models and data agree well only if CO depletion is considered. However, the uncertainties on the initial conditions limited our interpretation of the observations. Our new method can be used to design future ad hoc observational strategies to collect better data and give conclusive answers on disc evolution., Comment: 10 pages, 9 figures; accepted for publication in A&A Letters. Code and data available at https://github.com/fzagaria/COpops.git
Published: 2023
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37. Planet formation in the PDS 70 system: Constraining the atmospheric chemistry of PDS 70b and c

Author: Cridland, A. J., Facchini, S., van Dishoeck, E. F., Benisty, M., Cridland, A. J., Facchini, S., van Dishoeck, E. F., and Benisty, M.
Abstract: Understanding the chemical link between protoplanetary disks and planetary atmospheres is complicated by the fact that the popular targets in the study of disks and planets are widely separated both in space and time. The 5 Myr PDS 70 systems offers a unique opportunity to directly compare the chemistry of a giant planet's atmosphere to the chemistry of its natal disk. To that end, we derive our current best physical and chemical model for the PDS 70 disk through forward modelling of the $^{12}$CO, C$^{18}$O, and C$_2$H emission radial profiles with the thermochemical code DALI and find a volatile C/O ratio above unity in the outer disk. Using what we know of the PDS 70 disk today, we analytically estimate the properties of the disk as it was 4 Myr in the past when we assume that the giant planets started their formation, and compute a chemical model of the disk at that time. We compute the formation of PDS 70b and PDS 70c using the standard core accretion paradigm and account for the accretion of volatile and refractory sources of carbon and oxygen to estimate the resulting atmospheric carbon-to-oxygen number ratio (C/O) for these planets. Our inferred C/O ratio of the gas in the PDS 70 disk indicates that it is marginally carbon rich relative to the stellar C/O = 0.44 which we derive from an empirical relation between stellar metallicity and C/O. Under the assumption that the disk has been carbon rich for most of its lifetime, we find that the planets acquire a super-stellar C/O in their atmospheres. If the carbon-rich disk is a relatively recent phenomenon (i.e. developed after the formation of the planets at $\sim 1$ Myr) then the planets should have close to the stellar C/O in their atmospheres. This work lays the groundwork to better understand the disk in the PDS 70 system as well as the planet formation scenario that produce its planets., Comment: 18 pages, 14 figures, 5 tables, accepted for publication in A&A
Published: 2023
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38. A spectacular jet from the bright 244-440 Orion proplyd: the MUSE NFM view

Author: Kirwan, A., Manara, C. F., Whelan, E. T., Robberto, M., McLeod, A. F., Facchini, S., Beccari, G., Miotello, A., Schneider, P. C., Murphy, A., Vicente, S., Kirwan, A., Manara, C. F., Whelan, E. T., Robberto, M., McLeod, A. F., Facchini, S., Beccari, G., Miotello, A., Schneider, P. C., Murphy, A., and Vicente, S.
Abstract: In this work we present the highest spatial and spectral resolution integral field observations to date of the bipolar jet from the Orion proplyd 244-440 using MUSE NFM) observations on the VLT. We observed a previously unreported chain of six distinct knots in a roughly S-shaped pattern, and by comparing them with HST images we estimated proper motions in the redshifted knots of 9.5 mas yr$^{-1}$ with an inclination angle of $73^{\circ}$, though these quantities could not be measured for the blueshifted lobe. Analysis of the [FeII] and [NiII] lines suggests jet densities on the order of $\sim 10^5$ cm$^{-3}$. We propose that the observed S-shaped morphology originates from a jet launched by a smaller source with $M_\star < 0.2$ M$_{\odot}$ in orbital motion around a larger companion of $M_\star \simeq 0.5$ M$_{\odot}$ at a separation of 30-40 au. The measured luminosities of the knots using the [OI]$\lambda6300$ and [SII]$\lambda6731$ lines were used to estimate a lower limit to the mass-loss rate in the jet of $1.3 \times 10^{-11}$ M$_{\odot}$ yr$^{-1}$ and an upper limit of $10^{-9}$ M$_{\odot}$ yr$^{-1}$, which is typical for low-mass driving sources. While the brightness asymmetry between the redshifted and blueshifted lobes is consistent with external irradiation, further analysis of the [NiII] and [FeII] lines suggests that photoionization of the jet is not likely to be a dominant factor, and that the emission is dominated by collisional excitation. The dynamical age of the jet compared to the anticipated survival time of the proplyd demonstrates that photoevaporation of the proplyd occurred prior to jet launching, and that this is still an active source. These two points suggest that the envelope of the proplyd may shield the jet from the majority of external radiation, and that photoionization of the proplyd does not appear to impact the ability of a star to launch a jet., Comment: 30 pages, 20 figures
Published: 2023
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39. Reflections on nebulae around young stars: A systematic search for late-stage infall of material onto Class II disks

Author: Gupta, Aashish, Miotello, Anna, Manara, Carlo F., Williams, Jonathan P., Facchini, Stefano, Beccari, Giacomo, Birnstiel, Til, Ginski, Christian, Hacar, Alvaro, Küffmeier, Michael, Testi, Leonardo, Tychoniec, Lukasz, Yen, Hsi-Wei, Gupta, Aashish, Miotello, Anna, Manara, Carlo F., Williams, Jonathan P., Facchini, Stefano, Beccari, Giacomo, Birnstiel, Til, Ginski, Christian, Hacar, Alvaro, Küffmeier, Michael, Testi, Leonardo, Tychoniec, Lukasz, and Yen, Hsi-Wei
Abstract: Context. While it is generally assumed that Class II sources evolve largely in isolation from their environment, many still lie close to molecular clouds and may continue to interact with them. This may result in late accretion of material onto the disk that can significantly influence disk processes and planet formation. Aims. In order to systematically study late infall of gas onto disks, we identify candidate Class II sources in close vicinity to a reflection nebula (RN) that may be undergoing this process. Methods. First we targeted Class II sources with known kilo-au scale gas structures - possibly due to late infall of material - and we searched for RNe in their vicinity in optical and near-infrared images. Second, we compiled a catalogue of Class II sources associated with RNe and looked for the large-scale CO structures in archival ALMA data. Using the catalogues of protostars and RNe, we also estimated the probability of Class II sources interacting with surrounding material. Results. All of the sources with large-scale gas structures also exhibit some reflection nebulosity in their vicinity. Similarly, at least five Class II objects associated with a prominent RNe, and for which adequate ALMA observations are available, were found to have spirals or stream-like structures which may be due to late infall. We report the first detection of these structures around S CrA. Conclusions. Our results suggest that a non-negligible fraction of Class II disks in nearby star-forming regions may be associated with RNe and could therefore be undergoing late accretion of gas. Surveys of RNe and kilo-au scale gas structures around Class II sources will allow us to better understand the frequency and impact of late-infall phenomena., Comment: Accepted for publication in Astronomy & Astrophysics
Published: 2023
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40. Disk Evolution Study Through Imaging of Nearby Young Stars (DESTINYS): Characterization of the young star T CrA and its circumstellar environment

Author: Rigliaco, E., Gratton, R., Ceppi, S., Ginski, C., Hogerheijde, M., Benisty, M., Birnstiel, T., Dima, M., Facchini, S., Garufi, A., Bae, J., Langlois, M., Lodato, G., Mamajek, E., Manara, C. F., Ménard, F., Ribas, Á., Zurlo, A., Rigliaco, E., Gratton, R., Ceppi, S., Ginski, C., Hogerheijde, M., Benisty, M., Birnstiel, T., Dima, M., Facchini, S., Garufi, A., Bae, J., Langlois, M., Lodato, G., Mamajek, E., Manara, C. F., Ménard, F., Ribas, Á., and Zurlo, A.
Abstract: Birth environments of young stars have strong imprints on the star itself and their surroundings. We present a detailed analysis of the wealthy circumstellar environment around the young Herbig Ae/Be star TCrA. Our aim is to understand the nature of the stellar system and the extended circumstellar structures as seen in scattered light images. We conduct our analysis combining archival data, and new adaptive optics high-contrast and high-resolution images. The scattered light images reveal the presence of a complex environment composed of a bright forward scattering rim of the disk's surface that is seen at very high inclination, a dark lane of the disk midplane, bipolar outflows, and streamer features likely tracing infalling material from the surrounding birth cloud onto the disk. The analysis of the light curve suggests the star is a binary with a period of 29.6yrs. The comparison of the scattered light images with ALMA continuum and 12CO line emission shows the disk is in keplerian rotation, with the northern side of the outflowing material receding, while the southern side approaching the observer. The disk is itself seen edge-on. The direction of the outflows seen in scattered light is in agreement with the direction of the more distant molecular hydrogen emission-line objects (MHOs) associated to the star. Modeling of the SED using a radiative transfer scheme well agrees with the proposed configuration, as well as the hydrodynamical simulation performed using a Smoothed Particle Hydrodynamics code. We find evidence of streamers of accreting material around TCrA. These streamers connect the filament along which TCrA is forming with the outer parts of the disk, suggesting that the strong misalignment between the inner and outer disk is due to a change in the direction of the angular momentum of the material accreting on the disk during the late phase of star formation., Comment: 17 pages, 14 figures
Published: 2023
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41. A kinematically detected planet candidate in a transition disk

Author: Stadler, Jochen, Benisty, Myriam, Izquierdo, Andrés F., Facchini, Stefano, Teague, Richard, Kurtovic, Nicolas, Pinilla, Paola, Bae, Jaehan, Ansdell, Megan, Loomis, Ryan, Mayama, Satoshi, Pérez, Laura M., Testi, Leonardo, Stadler, Jochen, Benisty, Myriam, Izquierdo, Andrés F., Facchini, Stefano, Teague, Richard, Kurtovic, Nicolas, Pinilla, Paola, Bae, Jaehan, Ansdell, Megan, Loomis, Ryan, Mayama, Satoshi, Pérez, Laura M., and Testi, Leonardo
Abstract: Transition disks are protoplanetary disks with inner cavities possibly cleared by massive companions, which makes them prime targets to observe at high resolution to map their velocity structure. We present ALMA Band 6 dust and gas observations of the transition disk around RXJ1604.3-2130 A, known to feature nearly symmetric shadows in scattered light. We studied the $^{12}$CO line channel maps and moment maps of the line of sight velocity and peak intensity. We fitted a Keplerian model of the channel-by-channel emission to study line profile differences and produced deprojected radial profiles for all velocity components. The $^{12}$CO emission shows a cavity inwards of $\sim$56 au and within the dust continuum ring at 81 au. The azimuthal brightness variations in the $^{12}$CO line and dust continuum are broadly aligned with the shadows detected in scattered-light observations. We find a strong localized non-Keplerian feature toward the west within the continuum ring (at $R=41\pm 10$ au and $PA=280\pm 2 ^\circ$). A tightly wound spiral is also detected which extends over 300$^\circ$ in azimuth, possibly connected to the localized non-Keplerian feature. Finally, a bending of the iso-velocity contours within the gas cavity indicates a highly perturbed inner region, possibly related to the presence of a misaligned inner disk. While broadly aligned with the scattered-light shadows, the localized non-Keplerian feature cannot be solely due to changes in temperature. Instead, we interpret the kinematical feature as tracing a massive companion located at the edge of the dust continuum ring. We speculate that the spiral is caused by buoyancy resonances driven by planet-disk interactions. However, this potential planet at $\sim$41 au cannot explain the gas-depleted cavity, the low accretion rate, and the misaligned inner disk, which suggests the presence of another companion closer in., Comment: 13 pages, 14 figures. To be published in Astronomy & Astrophysics Letters
Published: 2023
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42. Da “onda rosa” à “maré azul”: : crise e mudança no sistema partidário uruguaio (2005-2019)

Author: de Freixo, Adriano, da Silva, Allana Facchini, de Freixo, Adriano, and da Silva, Allana Facchini
Abstract: In this article, we propose to analyze the transformations that occurred in Uruguay’s party system between 2005 and 2019, placing them within the Latin American context of the rise and decline of the so-called “pink wave” and the subsequent outline of a “blue tide”. Thus, we seek to understand the conditions under which the decline of traditional uruguayan political parties took place; the growth, the electoral victories and the cycle of governments of the Frente Amplio; the rearticulation and renewal of the traditional right and; the emergence and strengthening of a new far-right party, the Cabildo Abierto. Finally, we seek to discuss and problematize the need to update the theoretical debate on the Uruguayan party system, in view of the greater fragmentation resulting from the 2019 elections., Neste artigo, nos propomos a analisar as transformações ocorridas no sistema partidário uruguaio entre 2005 e 2019, situando-as dentro do contexto latino-americano de ascensão e declínio da chamada “onda rosa” e do posterior esboço de uma “maré azul”. Assim, buscamos entender as condições nas quais se deram o declínio dos partidos políticos uruguaios tradicionais; o crescimento, as vitórias eleitorais e o ciclo de governos da Frente Ampla; a rearticulação e renovação da direita tradicional e; o surgimento e fortalecimento de um novo partido de extrema-direita, o Cabildo Abierto. Finalmente, procuramos discutir e problematizar a necessidade de atualização do debate teórico sobre o sistema partidário uruguaio, tendo em vista o quadro de maior fragmentação decorrente das eleições de 2019.
Published: 2023

43. Intersectional coalitions towards a just agroecology: weaving mutual aid and agroecology in Barcelona and Seville

Author: Ministerio de Ciencia e Innovación (España), López-García, Daniel [0000-0003-2265-880X], Facchini, Francesco, López-García, Daniel, Villamayor‑Tomas, Sergio, Corbera, Esteve, Ministerio de Ciencia e Innovación (España), López-García, Daniel [0000-0003-2265-880X], Facchini, Francesco, López-García, Daniel, Villamayor‑Tomas, Sergio, and Corbera, Esteve
Abstract: Although in theory social justice is considered as a core dimension of agroecological transitions, alternative food initiatives related to agroecology have been criticised for their exclusionary practices based on important social and economic biases. In this article, we adopt the lens of political intersectionality to study two cases of Agroecology-oriented Food Redistribution Coalitions in Spain that emerged to address the rising levels of food insecurity during the COVID-19 pandemic. We f ind that the coalitions represent a convergence of diverse social struggles, placing intersectionally marginalized groups at the centre of their activism. However, we also uncover that coalition members participate in different ways depending on their socioeconomic profiles, which could perpetuate inequalities in organizational practices. One major point of tension is the need to balance the goal of providing access to healthy and sustainable food with the affordability of such produce. This leads to the adoption of hybrid food networks that include conventionally produced food. We also highlight that while the predominance of women in these coalitions reflects the unequal distribution of food-related care work in society, the collectivization of such work through AFRCs practices points to a transformation of gender relations. Territorialized alliances between actors from urban and rural settings and between urban centers and peripheries are established through the coalitions. However, such networks fall short on involving large numbers of agroecology-oriented initiatives and providing direct encounters between consumers and producers. Overall, the article underscores the importance of addressing intersecting inequalities within alternative food initiatives and argues that intersectional coalitions offer an intriguing example of how to promote such understanding and pave the way towards (more) just agroecological transitions.
Published: 2023

44. Observing planetesimal formation under streaming instability in the rings of HD 163296

Author: Zagaria, Francesco, Clarke, Cathie J., Booth, Richard A., Facchini, Stefano, Rosotti, Giovanni P., Zagaria, Francesco, Clarke, Cathie J., Booth, Richard A., Facchini, Stefano, and Rosotti, Giovanni P.
Abstract: We introduce a new technique to determine the gas turbulence and surface density in bright disc rings, under the assumption that dust growth is limited by turbulent fragmentation at the ring centre. We benchmark this prescription in HD 163296, showing that our measurements are consistent with available turbulence upper limits and agree with independent estimates of the gas surface density within a factor of two. We combine our results with literature measurements of the dust surface density and grain size to determine the dust-to-gas ratio and Stokes number in the 67 au and 100 au rings. Our estimates suggest that particle clumping is taking place under the effect of streaming instability (SI) in the 100 au ring. Even though in the presence of external isotropic turbulence this process might be hindered, we provide evidence that turbulence is non-isotropic in both rings and likely originating from mechanisms (such as ambipolar diffusion) that could ease particle clumping under SI. Finally, we determine the mass accretion rate under the assumption that the disc is in steady state and turbulence regulates angular momentum transport. Our results are in tension with spectroscopic measurements and suggest that other mechanisms might be responsible for accretion, in qualitative agreement with the detection of a magneto-centrifugal wind in this system. Applying our method to larger samples can be used to statistically assess if SI is a viable mechanism to form planetesimals in bright rings., Comment: 13 pages, 4 figures; accepted for publication on ApJL
Published: 2023

45. The external photoevaporation of structured protoplanetary disks

Author: Gárate, Matías, Pinilla, Paola, Haworth, Thomas J., Facchini, Stefano, Gárate, Matías, Pinilla, Paola, Haworth, Thomas J., and Facchini, Stefano
Abstract: The dust in planet-forming disks evolve rapidly through growth and radial drift, and external photoevaporation also contributes to this evolution in massive star-forming regions. We test whether the presence of substructures can explain the survival of the dust component and observed millimeter continuum emission in protoplanetary disks located within massive star-forming regions. We also characterize the dust content removed by the photoevaporative winds. For this, we performed hydrodynamical simulations of protoplanetary disks subject to irradiation fields of $F_{UV} = 10^2$, $10^3$, and $10^4\, G_0$, with different dust trap locations. We used the FRIED grid to derive the mass loss rate for each irradiation field and disk properties, and then measure the evolution of the dust mass over time. For each simulation we estimate continuum emission at $\lambda = 1.3\, \textrm{mm}$ along with the radii encompassing $90\%$ of the continuum flux, and characterize the dust size distribution entrained in the photoevaporative winds, along with the resulting far-ultraviolet (FUV) cross section. Our simulations show that the presence of dust traps can extend the lifetime of the dust component of the disk to a few millionyears if the FUV irradiation is $F_{UV} \lesssim 10^3 G_0$, but only if the dust traps are located inside the photoevaporative truncation radius. The dust component of a disk quickly disperse if the FUV irradiation is strong ($10^4\, G_0$) or if the substructures are located outside the photoevaporation radius. We do find however, that the dust grains entrained with the photoevaporative winds may result in an absorption FUV cross section of $\sigma \approx 10^{-22}\, \textrm{cm}^2$ at early times of evolution ($<$0.1 Myr), which is enough to trigger a self-shielding effect that reduces the total mass loss rate, and slow down the disk dispersal in a negative feedback loop process., Comment: Accepted for publication in A&A
Published: 2023
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46. Disk Evolution Study Through Imaging of Nearby Young Stars (DESTINYS): HD 34700 A unveils an inner ring

Author: Columba, G., Rigliaco, E., Gratton, R., Mesa, D., D'Orazi, V., Ginski, C., Engler, N., Williams, J. P., Bae, J., Benisty, M., Birnstiel, T., Delorme, P., Dominik, C., Facchini, S., Menard, F., Pinilla, P., Rab, C., Ribas, Á., Squicciarini, V., van Holstein, R. G., Zurlo, A., Columba, G., Rigliaco, E., Gratton, R., Mesa, D., D'Orazi, V., Ginski, C., Engler, N., Williams, J. P., Bae, J., Benisty, M., Birnstiel, T., Delorme, P., Dominik, C., Facchini, S., Menard, F., Pinilla, P., Rab, C., Ribas, Á., Squicciarini, V., van Holstein, R. G., and Zurlo, A.
Abstract: Context. The study of protoplanetary disks is fundamental to understand their evolution and interaction with the surrounding environment, and to constrain planet formation mechanisms. Aims. We aim at characterising the young binary system HD 34700 A, which shows a wealth of structures. Methods. Taking advantage of the high-contrast imaging instruments SPHERE at the VLT, LMIRCam at the LBT, and of ALMA observations, we analyse this system at multiple wavelengths. We study the rings and spiral arms morphology and the scattering properties of the dust. We discuss the possible causes of all the observed features. Results. We detect for the first time, in the H${\alpha}$ band, a ring extending from $\sim$65 au to ${\sim}$120 au, inside the ring already known from recent studies. These two have different physical and geometrical properties. Based on the scattering properties, the outer ring may consist of grains of typical size $a_{out} > 4 {\mu}m$, while the inner ring of smaller grains ($a_{in} <= 0.4 {\mu m}$). Two extended logarithmic spiral arms stem from opposite sides of the disk. The outer ring appears as a spiral arm itself, with a variable radial distance from the centre and extended substructures. ALMA data confirm the presence of a millimetric dust substructure centred just outside the outer ring, and detect misaligned gas rotation patterns for HD 34700 A and B. Conclusions. The complexity of HD 34700 A, revealed by the variety of observed features, suggests the existence of one or more disk-shaping physical mechanisms. Possible scenarios, compatible with our findings, involve the presence inside the disk of a yet undetected planet of several Jupiter masses and the system interaction with the surroundings by means of gas cloudlet capture or flybys. Further observations with JWST/MIRI or ALMA (gas kinematics) could shed more light on these., Comment: Accepted for publication on A&A. 14 + 5 pages, 9 + 7 figures (text + appendix)
Published: 2023
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47. Distributed Autonomous Organizations as Public Services Supplying Platform

Author: De Gasperis, Giovanni, Facchini, Sante Dino, Michilli, Maurizio, De Gasperis, Giovanni, Facchini, Sante Dino, and Michilli, Maurizio
Abstract: Servizi Elaborazioni Dati SpA is a public company owned by Municipality of L Aquila, it supplies the institution with network services and software applications for distributing services to citizens. The future policy of the company is to enlarge the offer of its services to nearby communities that are unable to set up and maintain their own network and software structures. This paper presents thus a possible architecture model to support small municipalities in supplying public services to citizens, with the aid of SED Spa. Through second level platforms based on Blockchain networks and Multi-agents Systems running on smart contracts, the system will focus on Waste Tax (Ta.Ri) management system in the Fascicolo del Cittadino environment., Comment: Presented at 8th Italian Conference on ICT for Smart Cities And Communities, 14-16 September 2022 - University of Camerino - Ascoli Piceno, Italy
Published: 2023

48. Secured Fiscal Credit Model: Multi-Agent Systems And Decentralized Autonomous Organisations For Tax Credit's Tracking

Author: De Gasperis, Giovanni, Facchini, Sante Dino, Letteri, Ivan, De Gasperis, Giovanni, Facchini, Sante Dino, and Letteri, Ivan
Abstract: Tax incentives and fiscal bonuses have had a significant impact on the Italian economy over the past decade. In particular, the "Superbonus 110" tax relief in 2020, offering a generous 110% deduction for expenses related to energy efficiency improvements and seismic risk reduction in buildings, has played a pivotal role. However, the surge in construction activities has also brought about an unfortunate increase in fraudulent activities. To address this challenge, our research introduces a practical system for monitoring and managing the entire process of the Superbonus 110 tax credit, from its initiation to redemption. This system leverages artificial intelligence and blockchain technology to streamline tax credit management and incorporates controllers based on a Decentralised Autonomous Organisation architecture, bolstered by a Multi-agent System. The outcome of our work is a system capable of establishing a tokenomics framework that caters to the needs and functionalities of both investors and operators. Moreover, it features a robust control system to prevent inadvertent errors like double spending, overspending, and deceitful practices such as false claims of completed work. The collaborative approach between the Decentralised Autonomous Organisation and the Multi-agent System enhances trust and security levels among participants in a competitive environment where potential fraudsters might attempt to exploit the system. It also enables comprehensive tracking and monitoring of the entire Superbonus process. In the realm of engineering, our project represents an innovative fusion of blockchain technology and Multi-agent Systems, advancing the application of artificial intelligence. This integration guarantees the validation, recording, and execution of transactions with a remarkable level of trust and transparency.
Published: 2023

49. A inteligência artificial diagnóstica e o seu impacto na responsabilidade civil do médico por erro de diagnóstico

Author: Facchini Neto, Eugênio and Facchini Neto, Eugênio
Published: 2023

50. Segredo de justiça: meio de tutela e de restrição a liberdades e direitos fundamentais

Author: Facchini Neto, Eugênio and Facchini Neto, Eugênio
Published: 2023

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