1. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery
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R Ahmed, W U, Bhatia, S, A McLean, K, Khaw, R, Baker, D, K Kamarajah, S, Bell, S, Nepogodiev, D, M Harrison, E, C Glasbey, J, Borakati, A, Burke, J, M Drake, T, F Bath, M, A Claireaux, H, Gundogan, B, Mohan, M, Deekonda, P, Kong, C, Joyce, H, Mcnamee, L, Woin, E, Khatri, C, E Fitzgerald, J, Bhangu, A, Arulkumaran, N, Duthie, F, Hughes, J, D Pinkney, T, Prowle, J, Richards, T, Thomas, M, Blanco-Colino, R, J Chapman, S, Pata, F, Pellino, G, Sgrò, A, Soares, A, van Elst, T, Van Straten, S, H Knowles, C, Dynes, K, Patel, M, Patel, P, Wigley, C, Suresh, R, Shaw, A, Klimach, S, Jull, P, Evans, D, Preece, R, Ibrahim, I, Manikavasagar, V, Smith, R, S Brown, F, Teo, R, Y Sim, D P, E Logan, A, Barai, I, Amin, H, Suresh, S, Sethi, R, Gul, W, Bolton, W, Corbridge, O, Horne, L, Attalla, M, Morley, R, Robinson, C, Hoskins, T, Mcallister, R, Lee, S, Dennis, Y, Nixon, G, Heywood, E, Wilson, H, Ng, L, Samaraweera, S, Mills, A, Doherty, C, Belchos, J, Phan, V, Lim, M, A Miller, F, Chouari, T, Gardner, T, Goergen, N, B Hayes, J D, S MacLeod, C, Mccormack, R, Mckinley, A, Mckinstry, S, Milligan, W, Ooi, L, M Rafiq, N, Sammut, T, Sinclair, E, Smith, M, Wong, J, D Ablett, A, Tie-Gill, T, Ramsay, G, De Paola, L, Mcguckin, S, Alshakhs, A, Ahmeidat, A, A Francis, A, Baker, C, R Boulton, A P, Collins, J, C Copley, H, Fearnhead, N, Fox, H, Mah, T, Mckenna, J, Naruka, V, Nigam, N, Nourallah, B, Perera, S, Qureshi, A, Saggar, S, Sun, L, Wang, X, D Yang, D, Ali, Z, Mullarkey, L, Walshe, R, Lewis, E, Berry, B, Moneim, J, Mookerjee, S, Al-Hadithi, A, Caroll, P, Doyle, C, Elangovan, S, Falamarzi, A, Gascon Perai, K, Greenan, E, Jain, D, Lang-Orsini, M, Lim, S, O'Byrne, L, Ridgway, P, Van der Laan, S, Arthur, J, Barclay, J, Bradley, P, Edwin, C, Finch, E, Hayashi, E, Hopkins, M, Kelly, D, Kelly, M, Mccartan, N, Ormrod, A, Pakenham, A, Christy, S, Hayward, J, Hitchen, C, Kishore, A, Martins, T, Philomen, J, Rao, R, Rickards, C, Burns, N, Copeland, M, Durand, C, Dyal, A, Ghaffar, A, Gidwani, A, Grant, M, Gribbon, C, Gruhn, A, Leer, M, Ojofeitimi, O, Carroll, L, Hylands, A, P Delaugere, L, Reveendran, D, Ahmad, K, Beattie, G, Beatty, M, Campbell, G, Donaldson, G, Graham, S, Holmes, D, Kanabar, S, Liu, H, Mccann, C, Stewart, R, Vara, S, Coulter, C, Ralston, C, Laverty, L, Gallagher, P, Ajibola-Taylor, O, E Andah, E J, Ani, C, O Cabdi, N M, Ito, G, Jones, M, Komoriyama, A, Titu, L, Ahmed, A, Q Yeo, Y, Elliott, D, Bennett, J, Mcnamara, M, Sivarajah, S, Dunmore, C, Basra, M, Gallogly, P, Harinath, G, H Leong, S, Pradhan, A, Siddiqui, I, Zaat, S, Ali, A, Galea, M, L Looi, W, K Ng, J C, H Farhan-Alanie, M M, Aitken, G, Nair, M, H Aly, M, Buari, M, Atkin, G, Azizi, A, Cargill, Z, China, Z, Elliot, J, Jebakumar, R, Lam, J, Mudalige, G, Onyerindu, C, Renju, M, Shankar Babu, V, Ahmed, K, Sheikh, Z, Monks, M, Lehmann, J, Rotimi, O, Hussain, M, Joji, N, Lovett, B, Mownah, H, Dwyer-Hemmings, L, Busuttil, A, Powell, J, Hensher, C, Vivian, F, Ali, B, Cresswell, B, K Dhillon, A, S Dupaguntla, Y, Hungwe, C, D Lowe-Zinola, J, H Tsang, J C, Wcislo, K, Bevan, K, Cardus, C, Duggal, A, Hossain, S, Mchugh, M, Scott, M, Millar, Z, Hirosue, S, Ogunmwonyi, I, Nakakande, D, Chan, F, Evans, R, Gurung, E, Haughey, B, Jacob-Ramsdale, B, Kerr, M, Lee, J, Mccann, E, O'Boyle, K, Reid, N, Kwek, I, Gaze, H, Nirmalanantha, A, A Bin Amran, M, Foulkes, A, Jones, N, F Lau, I S, Hayat, F, Hodgson, S, Johnston, R, Jones, W, Khan, M, Linn, T, Long, S, Seetharam, P, Shaman, S, Smart, B, Pillai, S, Khoury, G, Powell, T, Maleyko, I, Sangheli, A, Ransome, M, Isse, M, Aromolaran, O, Bholah, H, Anilkumar, A, Davies, J, Griffith, J, Hughes, B, Islam, Y, Kidanu, D, Mushaini, N, Qamar, I, Robinson, H, Schramm, M, Yan Tan, C, Murray, V, Theocharidou, L, Malik, T, Janmohamed, I, Carhart, B, Khan, A, Apperley, H, Billyard, C, M Blazeby, J, P Cannon, S, Carse, S, Göpfert, A, Loizidou, A, Parkin, J, Sanders, E, Sharma, S, Slade, G, Telfer, R, Whybrow Huppatz, I, Worley, E, Asif, A, Hullait, R, Quinn, P, Rylance, A, Butt, S, Leathes, J, Chandramoorthy, L, Friend, C, Harris, L, Jain, P, J Karim, M, Killington, K, Mcgillicuddy, J, Rafferty, C, Rahunathan, N, Rayne, T, Varathan, Y, Verma, N, Zanichelli, D, Arneill, M, Brown, F, Campbell, B, Crozier, L, Henry, J, Mccusker, C, Prabakaran, P, Wilson, R, Karelia, S, M Clements, J, Rainey, M, Asif, U, Connor, M, Dindyal, S, Math, N, Pagarkar, A, Saleem, H, Seth, I, Standfield, N, Swartbol, T, Adamson, R, E Choi, J, El Tokhy, O, Ho, W, R Javaid, N, S Mehdi, A, Menon, D, Plumptre, I, Sturrock, S, Turner, J, Warren, O, Joshi, N, Rahman, A, Gallagher, M, Crane, E, Ferris, B, Gadsby, C, Smallwood, J, Vipond, M, Wilson, V, Amarnath, T, Doshi, A, Gregory, C, Kandiah, K, Powell, B, Spoor, H, Toh, C, Vizor, R, Rebuffa, N, Abdelgalil, R, Siaw Yen Lai, R, Smith, E, Common, M, Dunleavy, K, Harris, S, Luo, C, Mesbah, Z, Prem Kumar, A, Redmond, A, Skulsky, S, Walsh, T, Daly, D, Deery, L, Epanomeritakis, E, Harty, M, Kane, D, Khan, K, Mackey, R, Mcconville, J, 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M, France, B, Grace, R, Puddy, H, Soor, P, Kisiel, A, Woodmass, M, Hayden, H, Ali, Y, Husain, S, Ali, M, Dhillon, P, Faraj, A, Gerard, L, Glover, M, Imran, H, Kim, S, Patrick, Y, Peto, J, Prabhudesai, A, Tang, A, Vadgama, N, Dhaliwal, R, Ecclestone, T, Harris, A, Ong, D, Patel, D, Philp, C, Stewart, E, Wang, L, Wong, E, Xu, Y, Ashaye, T, Fozard, T, Galloway, F, Kaptanis, S, Mistry, P, Nguyen, T, Olagbaiye, F, Osman, M, Philip, Z, Rembacken, R, Tayeh, S, Theodoropoulou, K, Y Liu, F, Arnold, A, C Pedersen, A, Cunha, P, Ahmed, M, Al Zawawi, S, Kudva, V, Herman, A, Lau, J, Saha, A, Trotter, M, Miscampbell, M, V Robinson, A, Johnston, J, Dharni, A, Lamb, S, Westerman, T, Adeleye, O, Cave, D, Gunwa, T, Magalhães, J, Makwana, S, Mason, R, Parish, M, Regan, H, Renwick, P, Roberts, G, Salekin, D, Sivakumar, C, Tariq, A, Liew, I, Mcdade, A, Stewart, D, Evans, E, Campbell, L, Gillespie, M, M Cheong, C, Hague, M, Hudson-Peacock, N, S Jackson, C E, James, F, Pitt, J, Y Walker, E, Kulathevanayagam, 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Gopaul, A, R Pentony, A, L Piong, C, Nossier, R, Hanna, J, Sabir, K, Y Eow, S, Ladak, N, Boersma, D, J Kamath, P, W Soh, T B, H Dyer, A, Y Chee, S, H Tan, I X, Kelliher, A, Scanlon, K, Adeusi, L, Howarth, N, Mccawley, N, O'Neill, A, R Jones, M, Saleh, R, Singh, A, O'Dwyer, N, C Mana, O, Gomez, H, Riba, L, Perez, J, Centeno, A, Ortega, C, E Ossola, M, Camarero, E, Martínez Illán, M, Aranda García, L, Lázaro Cardona, M, Montalvo Olmedo, C, Izquierdo Moreno, A, Cuenca Ramírez, A, Margarida, A, Pando, B, Liquete Marín, L, Pérez Calle, M, J Ramos Cordero, M, Sagredo Cuartango, A, Sánchez, E, Marcos Rodrigo, A, Fernandez, A, Curtis, C, Bosch, M, Triguero, D, Bosch Ramírez, M, De La Llave Serralvo, A, J Sánchez, M, Martín-Borregón, P, Quevedo, A, Martínez, J, M Marín, J, Rodríguez, P, Esteban Avendaño, I, Jiménez Relimpio, C, Lancho Lavilla, P, Blanco Bartolomé, I, Gómez Cano, I, Blasco Andrés, C, Abad-Motos, A, Marínez-Hurtado, E, Salvachua-Fernández, R, Muniesa, C, Avelino, L, Cholewa, H, Sancho-Muriel, J, Navasquillo, M, Navío, A, Abelló, D, De Jesus, M, Alvarez, E, Kefleyesus, A, Bugmann, A, M Piotet, L, Meijers, L, Tonchev, P, Tamosiunas, A, J Rottier, S, Negoi, I, R Bernado, I, Eftychiou, S, and L Lorenzon (ORCID:0000-0001-6736-0383)
- Abstract
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study ('IMAGINE') of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study ('Tayside') in major abdominal surgery (2011-2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results: In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655-0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323-0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specif
- Published
- 2022