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Background: Mycetoma is a chronic inflammatory disease of the skin that can extend to the fascia, tendons, muscles, and bones. Caused by a bacterium called actinomycetoma and a fungus called eumycetoma are responsible for mycetoma, both of which must be distinguished because they require different medical therapy. Eumycetoma is a localized disease, chronic, and growing slowly. Most of eumycetoma patients had delays in seeking medical care. Purpose: To provide an overview and discuss various aspects of eumycetoma, including its epidemiology, etiology, pathogenesis, classification, clinical picture, diagnosis, differential diagnosis, and therapy. Review: Eumycetoma infection begins as infectious agents enter through the skin with a minor trauma caused by objects contaminated with fungi, forming granular or granulomatous lesions with tract and sinus in there. The infection can spread from the site of inoculation into the muscles and bones. The diagnosis is based on anamnesis (chronic and painless), the triad of tumefaction, draining sinuses and grains, and laboratory investigation. It’s a difficult case, often recur and difficult to be surgical excisison, so that the best first option therapy is the combination of itraconazole and terbinafine itself as an alternative to surgical therapy at least 6 months. Conclusion: Eumycetoma is an infection caused by a fungus with granulomatous lesions with sinus formation and grains in it. The best first option therapy is the combination of itraconazole and terbinafine although it’s still an early case.

Mycetoma, a chronic and mutilating subcutaneous infection recognized by WHO as a neglected tropical disease, has been reported in over 25 countries in Africa, Asia and South America. In Latin America, Trematosphaeria grisea is assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed to Trematosphaeria grisea. Three cases analyzed were caused by Nigrograna mackinnonii. Data on an additional 21 strains in literature revealed that N. mackinnonii rather than T. grisea is responsible for most cases of black grain eumycetoma in Latin America.

Mycetoma, a chronic and mutilating subcutaneous infection recognized by WHO as a neglected tropical disease, has been reported in over 25 countries in Africa, Asia and South America. In Latin America, Trematosphaeria grisea is assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed to Trematosphaeria grisea. Three cases analyzed were caused by Nigrograna mackinnonii. Data on an additional 21 strains in literature revealed that N. mackinnonii rather than T. grisea is responsible for most cases of black grain eumycetoma in Latin America.

A 40-year-old kidney transplant male recipient was hospitalized for chronic abscess of the right foot in a context of immunodepression. The patient came from Djibouti and was in Belgium for a few days. He presented a right foot with a swelling localized on the first metatarsophalangeal joint which was excoriated (Figures 1 and 2) and was self-treated ineffectively with various local antiseptics for several months. He was in the operating room for an open biopsy done by plantar and dorsal approach to confirm the fungal infection. Treatment was not started with oral itraconazole because of the good evolution of the lesion. Pain diminished after a few days, and the patient was able to walk after a few weeks. © The Author 2011., SCOPUS: ar.j, info:eu-repo/semantics/published

A 40-year-old kidney transplant male recipient was hospitalized for chronic abscess of the right foot in a context of immunodepression. The patient came from Djibouti and was in Belgium for a few days. He presented a right foot with a swelling localized on the first metatarsophalangeal joint which was excoriated (Figures 1 and 2) and was self-treated ineffectively with various local antiseptics for several months. He was in the operating room for an open biopsy done by plantar and dorsal approach to confirm the fungal infection. Treatment was not started with oral itraconazole because of the good evolution of the lesion. Pain diminished after a few days, and the patient was able to walk after a few weeks. © The Author 2011., SCOPUS: ar.j, info:eu-repo/semantics/published