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1. A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

Author

Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Riggioni, Carmen [0000-0002-8745-0228], Comberiat, Pasquale [0000-0001-5209-9733], Giovannini, Mattia [0000-0001-9568-6882], Agache, Ioana [0000-0001-7994-364X], Akdis, Mubeccel [0000-0003-0554-9943], Alves-Correia, Magna [0000-0002-7676-5558], Antó, Josep M. [0000-0002-4736-8529], Azkur, Ahmet Kursat [0000-0002-5597-8917], Azkur, Dilek [0000-0002-4396-9087], Boccabella, Cristina [0000-0003-1942-8886], Breiteneder, Heimo [0000-0003-2022-8689], Carvalho, Daniela [0000-0002-0432-3339], Vecillas, Leticia de las [0000-0003-4969-5678], Diamant, Zuzana [0000-0003-0133-0100], Eguiluz-Gracia, Ibon [0000-0002-3774-931X], Eiwegger, Thomas [0000-0002-2914-7829], Fokkens, Wytske [0000-0003-4852-229X], Gao, Ya-dong [0000-0003-1251-7608], Nadeau, Kari C. [0000-0002-2146-2955], O'Mahony, Liam [0000-0003-4705-3583], Pfaar, Oliver [0000-0003-4374-9639], Sanak, Marek [0000-0001-7635-8103], Schwarze, Jürgen [0000-0002-6899-748X], Sokolowska, Milena [0000-0001-9710-6685], Torres Jaén, María José [0000-0001-5228-471X], Veen, Willem van de [0000-0001-9951-6688], Zelm, Menno C. van [0000-0003-4161-1919], Wang, De Yun [0000-0002-0909-2963], Zhang, Luo [0000-0002-0910-9884], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Akdis, Cezmi A. [0000-0001-8020-019X], Riggioni, Carmen, Comberiat, Pasquale, Giovannini, Mattia, Agache, Ioana, Akdis, Mubeccel, Alves-Correia, Magna, Antó, Josep M., Arcolaci, Alessandra, Azkur, Ahmet Kursat, Azkur, Dilek, Beken, Burcin, Boccabella, Cristina, Bousquet, Jean, Breiteneder, Heimo, Carvalho, Daniela, Vecillas, Leticia de las, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Eiwegger, Thomas, Eyerich, Stephanie, Fokkens, Wytske, Gao, Ya-dong, Hannachi, Farah, Johnston, Sebastian L., Jutel, Marek, Karavelia, Aspasia, Klimek, Ludfger, Moya, Beatriz, Nadeau, Kari C., O'Hehir, Robin, O'Mahony, Liam, Pfaar, Oliver, Sanak, Marek, Schwarze, Jürgen, Sokolowska, Milena, Torres Jaén, María José, Veen, Willem van de, Zelm, Menno C. van, Wang, De Yun, Zhang, Luo, Jiménez Saiz, Rodrigo, Akdis, Cezmi A., Consejo Superior de Investigaciones Científicas (España), Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Riggioni, Carmen [0000-0002-8745-0228], Comberiat, Pasquale [0000-0001-5209-9733], Giovannini, Mattia [0000-0001-9568-6882], Agache, Ioana [0000-0001-7994-364X], Akdis, Mubeccel [0000-0003-0554-9943], Alves-Correia, Magna [0000-0002-7676-5558], Antó, Josep M. [0000-0002-4736-8529], Azkur, Ahmet Kursat [0000-0002-5597-8917], Azkur, Dilek [0000-0002-4396-9087], Boccabella, Cristina [0000-0003-1942-8886], Breiteneder, Heimo [0000-0003-2022-8689], Carvalho, Daniela [0000-0002-0432-3339], Vecillas, Leticia de las [0000-0003-4969-5678], Diamant, Zuzana [0000-0003-0133-0100], Eguiluz-Gracia, Ibon [0000-0002-3774-931X], Eiwegger, Thomas [0000-0002-2914-7829], Fokkens, Wytske [0000-0003-4852-229X], Gao, Ya-dong [0000-0003-1251-7608], Nadeau, Kari C. [0000-0002-2146-2955], O'Mahony, Liam [0000-0003-4705-3583], Pfaar, Oliver [0000-0003-4374-9639], Sanak, Marek [0000-0001-7635-8103], Schwarze, Jürgen [0000-0002-6899-748X], Sokolowska, Milena [0000-0001-9710-6685], Torres Jaén, María José [0000-0001-5228-471X], Veen, Willem van de [0000-0001-9951-6688], Zelm, Menno C. van [0000-0003-4161-1919], Wang, De Yun [0000-0002-0909-2963], Zhang, Luo [0000-0002-0910-9884], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Akdis, Cezmi A. [0000-0001-8020-019X], Riggioni, Carmen, Comberiat, Pasquale, Giovannini, Mattia, Agache, Ioana, Akdis, Mubeccel, Alves-Correia, Magna, Antó, Josep M., Arcolaci, Alessandra, Azkur, Ahmet Kursat, Azkur, Dilek, Beken, Burcin, Boccabella, Cristina, Bousquet, Jean, Breiteneder, Heimo, Carvalho, Daniela, Vecillas, Leticia de las, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Eiwegger, Thomas, Eyerich, Stephanie, Fokkens, Wytske, Gao, Ya-dong, Hannachi, Farah, Johnston, Sebastian L., Jutel, Marek, Karavelia, Aspasia, Klimek, Ludfger, Moya, Beatriz, Nadeau, Kari C., O'Hehir, Robin, O'Mahony, Liam, Pfaar, Oliver, Sanak, Marek, Schwarze, Jürgen, Sokolowska, Milena, Torres Jaén, María José, Veen, Willem van de, Zelm, Menno C. van, Wang, De Yun, Zhang, Luo, Jiménez Saiz, Rodrigo, and Akdis, Cezmi A.

Abstract

In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID‐19). This disease, caused by the severe acute respiratory syndrome–related coronavirus 2 (SARS‐CoV‐2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID‐19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence‐based medical advice on SARS‐CoV‐2 and COVID‐19. Although the majority of the patients show a very mild, self‐limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID‐19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a “cytokine storm” leading to acute respiratory distress syndrome, endothelitis, thromboembolic complications, and multiorgan failure. The epidemiologic features of COVID‐19 are distinctive and have changed throughout the pandemic. Vaccine and drug development studies and clinical trials are rapidly growing at an unprecedented speed. However, basic and clinical research on COVID‐19–related topics should be based on more coordinated high‐quality studies. This paper answers pressing questions, formulated by young clinicians and scientists, on SARS‐CoV‐2, COVID‐19, and allergy, focusing on the following topics: virology, immunology, diagnosis, management of patients with allergic disease and asthma, treatment, clinical trials, drug discovery, vaccine development, and epidemiology. A total of 150 questions were answered by experts in the field providing a comprehensive and practical overview of COVID‐19 and allergic disease.

Published
2020

2. Alpine altitude climate treatment for severe and uncontrolled asthma:An EAACI position paper

Author

Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., Akdis, Cezmi A., Fieten, Karin B., Drijver-Messelink, Marieke T., Cogo, Annalisa, Charpin, Denis, Sokolowska, Milena, Agache, Ioana, Taborda-Barata, Luís Manuel, Eguiluz-Gracia, Ibon, Braunstahl, Gerrit J., Seys, Sven F., van den Berge, Maarten, Bloch, Konrad E., Ulrich, Silvia, Cardoso-Vigueros, Carlos, Kappen, Jasper H., Brinke, Anneke ten, Koch, Markus, Traidl-Hoffmann, Claudia, da Mata, Pedro, Prins, David J., Pasmans, Suzanne G.M.A., Bendien, Sarah, Rukhadze, Maia, Shamji, Mohamed H., Couto, Mariana, Oude Elberink, Hanneke, Peroni, Diego G., Piacentini, Giorgio, Weersink, Els J.M., Bonini, Matteo, Rijssenbeek-Nouwens, Lucia H.M., and Akdis, Cezmi A.

Abstract

Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro-immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.

Published
2022

3. Omics technologies in allergy and asthma research: An EAACI position paper

Author

Radzikowska, Urszula; https://orcid.org/0000-0002-7341-9764, Baerenfaller, Katja; https://orcid.org/0000-0002-1904-9440, Cornejo‐Garcia, José Antonio; https://orcid.org/0000-0003-3465-8735, Karaaslan, Cagatay; https://orcid.org/0000-0003-4857-0857, Barletta, Elena, Sarac, Basak Ezgi; https://orcid.org/0000-0003-1181-4598, Zhakparov, Damir, Villaseñor, Alma; https://orcid.org/0000-0002-6652-2739, Eguiluz‐Gracia, Ibon; https://orcid.org/0000-0002-3774-931X, Mayorga, Cristobalina, Sokolowska, Milena; https://orcid.org/0000-0001-9710-6685, Barbas, Coral, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Ollert, Markus, Chivato, Tomas, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Escribese, Maria M; https://orcid.org/0000-0001-5057-5150, Radzikowska, Urszula; https://orcid.org/0000-0002-7341-9764, Baerenfaller, Katja; https://orcid.org/0000-0002-1904-9440, Cornejo‐Garcia, José Antonio; https://orcid.org/0000-0003-3465-8735, Karaaslan, Cagatay; https://orcid.org/0000-0003-4857-0857, Barletta, Elena, Sarac, Basak Ezgi; https://orcid.org/0000-0003-1181-4598, Zhakparov, Damir, Villaseñor, Alma; https://orcid.org/0000-0002-6652-2739, Eguiluz‐Gracia, Ibon; https://orcid.org/0000-0002-3774-931X, Mayorga, Cristobalina, Sokolowska, Milena; https://orcid.org/0000-0001-9710-6685, Barbas, Coral, Barber, Domingo; https://orcid.org/0000-0002-5488-5700, Ollert, Markus, Chivato, Tomas, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, and Escribese, Maria M; https://orcid.org/0000-0001-5057-5150

Abstract

Allergic diseases and asthma are heterogenous chronic inflammatory conditions with several distinct complex endotypes. Both environmental and genetic factors can influence the development and progression of allergy. Complex pathogenetic pathways observed in allergic disorders present a challenge in patient management and successful targeted treatment strategies. The increasing availability of high-throughput omics technologies, such as genomics, epigenomics, transcriptomics, proteomics, and metabolomics allows studying biochemical systems and pathophysiological processes underlying allergic responses. Additionally, omics techniques present clinical applicability by functional identification and validation of biomarkers. Therefore, finding molecules or patterns characteristic for distinct immune-inflammatory endotypes, can subsequently influence its development, progression, and treatment. There is a great potential to further increase the effectiveness of single omics approaches by integrating them with other omics, and nonomics data. Systems biology aims to simultaneously and longitudinally understand multiple layers of a complex and multifactorial disease, such as allergy, or asthma by integrating several, separated data sets and generating a complete molecular profile of the condition. With the use of sophisticated biostatistics and machine learning techniques, these approaches provide in-depth insight into individual biological systems and will allow efficient and customized healthcare approaches, called precision medicine. In this EAACI Position Paper, the Task Force “Omics technologies in allergic research” broadly reviewed current advances and applicability of omics techniques in allergic diseases and asthma research, with a focus on methodology and data analysis, aiming to provide researchers (basic and clinical) with a desk reference in the field. The potential of omics strategies in understanding disease pathophysiology and key tools to reach unmet needs i

Published
2022

4. Local Respiratory Allergy: From Rhinitis Phenotype to Disease Spectrum

Author

Universidad de Sevilla. Departamento de : Bioquímica Médica y Biología Molecular e Inmunología, Testera-Montes, Almudena, Salas, Maria, Palomares, Francisca, Ariza, Adriana, Torres, María José, Rondón, Carmen, Eguiluz-Gracia, Ibon, Universidad de Sevilla. Departamento de : Bioquímica Médica y Biología Molecular e Inmunología, Testera-Montes, Almudena, Salas, Maria, Palomares, Francisca, Ariza, Adriana, Torres, María José, Rondón, Carmen, and Eguiluz-Gracia, Ibon

Published
2021

5. Comparing biologicals and small molecule drug therapies for chronic respiratory diseases : An EAACI Taskforce on Immunopharmacology position paper

Author

Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., Stellato, Cristiana, Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., and Stellato, Cristiana

Published
2019

6. Comparing biologicals and small molecule drug therapies for chronic respiratory diseases : An EAACI Taskforce on Immunopharmacology position paper

Author

Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., Stellato, Cristiana, Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., and Stellato, Cristiana

Published
2019

7. Comparing biologicals and small molecule drug therapies for chronic respiratory diseases : An EAACI Taskforce on Immunopharmacology position paper

Author

Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., Stellato, Cristiana, Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., and Stellato, Cristiana

Published
2019

8. Comparing biologicals and small molecule drug therapies for chronic respiratory diseases: An EAACI Taskforce on Immunopharmacology position paper

Author

CTI, Infection & Immunity, MS Dermatologie/Allergologie, Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., Stellato, Cristiana, CTI, Infection & Immunity, MS Dermatologie/Allergologie, Roth-Walter, Franziska, Adcock, Ian M., Benito-Villalvilla, Cristina, Bianchini, Rodolfo, Bjermer, Leif, Caramori, Gaetano, Cari, Luigi, Chung, Kian Fan, Diamant, Zuzana, Eguiluz-Gracia, Ibon, Knol, Edward F, Kolios, Antonios G.A., Levi-Schaffer, Francesca, Nocentini, Giuseppe, Palomares, Oscar, Puzzovio, Pier Giorgio, Redegeld, Frank A, van Esch, Betty C.A.M., and Stellato, Cristiana

Published
2019

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