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1. Urinary Amino-PAHs in relation to diesel engine emissions and urinary mutagenicity

Author

Zhang, Junfeng Jim, Zheng, Yuxin, Vermeulen, Roel, Liu, Xing Lucy, Dai, Yufei, Hu, Wei, He, Linchen, Lin, Yan, Ren, Dianzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Lan, Qing, Rothman, Nathaniel, Zhang, Junfeng Jim, Zheng, Yuxin, Vermeulen, Roel, Liu, Xing Lucy, Dai, Yufei, Hu, Wei, He, Linchen, Lin, Yan, Ren, Dianzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Lan, Qing, and Rothman, Nathaniel

Abstract

Diesel exhaust has long been of health concern due to established toxicity including carcinogenicity in humans. However, the precise components of diesel engine emissions that drive carcinogenesis are still unclear. Limited work has suggested that nitrated polycyclic aromatic hydrocarbons (NPAHs) such as 1-nitropyrene and 2-nitrofluorene may be more abundant in diesel exhaust. The present study aimed to examine whether urinary amino metabolites of these NPAHs were associated with high levels of diesel engine emissions and urinary mutagenicity in a group of highly exposed workers including both smokers and nonsmokers. Spot urine samples were collected immediately following a standard work shift from each of the 54 diesel engine testers and 55 non-tester controls for the analysis of five amino metabolites of NPAHs, and cotinine (a biomarker of tobacco smoke exposure) using liquid chromatography-mass spectrometry. An overnight urine sample was collected in a subgroup of non-smoking participants for mutagenicity analysis using strain YG1041 in the Salmonella (Ames) mutagenicity assay. Personal exposure to fine particles (PM 2.5) and more-diesel-specific constituents (elemental carbon and soot) was assessed for the engine testers by measuring breathing-zone concentrations repeatedly over several full work shifts. Results showed that it was 12.8 times more likely to detect 1-aminopyrene and 2.9 times more likely to detect 2-aminofluorene in the engine testers than in unexposed controls. Urinary concentrations of 1-aminopyrene were significantly higher in engine testers (p < 0.001), and strongly correlated with soot and elemental carbon exposure as well as mutagenicity tested in strain YG1041 with metabolic activation (p < 0.001). Smoking did not affect 1-aminopyrene concentrations and 1-aminopyrene relationships with diesel exposure. In contrast, both engine emissions and smoking affected 2-aminofluorene concentrations. The results confirm that urinary 1-aminopyr

Published
2023

2. Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA

Author

IRAS OH Epidemiology Chemical Agents, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, and Lan, Qing

Published
2023

3. Urinary Amino-PAHs in relation to diesel engine emissions and urinary mutagenicity

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Junfeng Jim, Zheng, Yuxin, Vermeulen, Roel, Liu, Xing Lucy, Dai, Yufei, Hu, Wei, He, Linchen, Lin, Yan, Ren, Dianzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Lan, Qing, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Junfeng Jim, Zheng, Yuxin, Vermeulen, Roel, Liu, Xing Lucy, Dai, Yufei, Hu, Wei, He, Linchen, Lin, Yan, Ren, Dianzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Lan, Qing, and Rothman, Nathaniel

Published
2023

4. Occupational exposure to diesel engine exhaust and serum levels of microRNAs in a cross-sectional molecular epidemiology study in China

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Hu, Wei, Wong, Jason Y Y, Dai, Yufei, Ren, Dianzhi, Blechter, Batel, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Rahman, Mohammad L, Dean Hosgood, H, Vermeulen, Roel C, Silverman, Debra T, Zheng, Yuxin, Lan, Qing, Rothman, Nathaniel, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Hu, Wei, Wong, Jason Y Y, Dai, Yufei, Ren, Dianzhi, Blechter, Batel, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Rahman, Mohammad L, Dean Hosgood, H, Vermeulen, Roel C, Silverman, Debra T, Zheng, Yuxin, Lan, Qing, and Rothman, Nathaniel

Published
2023

5. Alterations to biomarkers related to long-term exposure to diesel exhaust at concentrations below occupational exposure limits in the European Union and the USA

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Wong, Jason Yy, Blechter, Batel, Bassig, Bryan A, Dai, Yufei, Vermeulen, Roel, Hu, Wei, Rahman, Mohammad L, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood, H Dean, Rothman, Nathaniel, Silverman, Debra T, Zheng, Yuxin, and Lan, Qing

Published
2023

6. Proteomic analysis of serum in workers exposed to diesel engine exhaust

Author

Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, Lan, Qing, Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, and Lan, Qing

Abstract

Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using a targeted proteomics approach, we aimed to identify proteins associated with DEE and characterize these markers to understand the mechanisms of DEE-induced carcinogenicity. In this cross-sectional molecular epidemiology study, we measured elemental carbon (EC) using a personal air monitor and quantified 1317 targeted proteins in the serum using the SOMAScan assay (SOMALogic) among 19 diesel exposed factory workers and 19 unexposed controls. We used linear regressions to identify proteins associated with DEE and examined their exposure-response relationship across levels of EC using linear trend tests. We further examined pathway enrichment of DEE-related proteins using MetaCore. Occupational exposure to DEE was associated with altered levels of 22 serum proteins (permutation p

Published
2022

7. Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin

Author

Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., Lan, Qing, Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., and Lan, Qing

Abstract

We investigated whether exposure to carcinogenic diesel engine exhaust (DEE) was associated with altered adduct levels in human serum albumin (HSA) residues. Nano-liquid chromatography-high resolution mass spectrometry (nLC-HRMS) was used to measure adducts of Cys34 and Lys525 residues in plasma samples from 54 diesel engine factory workers and 55 unexposed controls. An untargeted adductomics and bioinformatics pipeline was used to find signatures of Cys34/Lys525 adductome modifications. To identify adducts that were altered between DEE-exposed and unexposed participants, we used an ensemble feature selection approach that ranks and combines findings from linear regression and penalized logistic regression, then aggregates the important findings with those determined by random forest. We detected 40 Cys34 and 9 Lys525 adducts. Among these findings, we found evidence that 6 Cys34 adducts were altered between DEE-exposed and unexposed participants (i.e., 841.75, 851.76, 856.10, 860.77, 870.43, and 913.45). These adducts were biologically related to antioxidant activity.

Published
2022

8. Association between diesel exhaust exposure and mitochondrial DNA methylation

Author

Seow, Wei Jie, Hu, Wei, Dai, Yufei, Vermeulen, Roel, Byun, Hyang-Min, Wong, Jason Y Y, Bassig, Bryan A, Blechter, Batel, Duan, Huawei, Niu, Yong, Downward, George, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Meng, Tao, Bin, Ping, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, Seow, Wei Jie, Hu, Wei, Dai, Yufei, Vermeulen, Roel, Byun, Hyang-Min, Wong, Jason Y Y, Bassig, Bryan A, Blechter, Batel, Duan, Huawei, Niu, Yong, Downward, George, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Meng, Tao, Bin, Ping, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Abstract

Objectives2.5) were assessed. mtDNA methylation for CpG sites (CpGs) from seven mitochondrial genes (

Published
2022

9. Proteomic analysis of serum in workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, and Lan, Qing

Published
2022

10. Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin

Author

IRAS OH Epidemiology Chemical Agents, Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., Lan, Qing, IRAS OH Epidemiology Chemical Agents, Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., and Lan, Qing

Published
2022

11. Proteomic analysis of serum in workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Rahman, M.L., Bassig, Bryan A., Dai, Yufei, Wong, Jason Y Y, Blechter, Batel, Hosgood, H. Dean, Ren, Danzhi, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Silverman, D.T., Vermeulen, Roel, Rothman, Nat, Zheng, Yuxin, and Lan, Qing

Published
2022

12. Exposure to diesel engine exhaust and alterations to the Cys34/Lys525 adductome of human serum albumin

Author

IRAS OH Epidemiology Chemical Agents, Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., Lan, Qing, IRAS OH Epidemiology Chemical Agents, Wong, Jason Y Y, Imani, Patrow, Grigoryan, Hasmik, Bassig, Bryan A., Dai, Yufei, Wei, Hu, Blechter, Batel, Rahman, Mohammad L, Ji, Bu Tian, Duan, Huawei, Niu, Yong, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Downward, George, Meliefste, Kees, Leng, Shuguang, Fu, Wei, Yang, Jufang, Ren, Dianzhi, Xu, Jun, Zhou, Baosen, Hosgood, H. Dean, Vermeulen, Roel, Zheng, Yuxin, Silverman, Debra T., Rothman, Nat, Rappaport, S.M., and Lan, Qing

Published
2022

13. Association between diesel exhaust exposure and mitochondrial DNA methylation

Author

IRAS OH Epidemiology Chemical Agents, Seow, Wei Jie, Hu, Wei, Dai, Yufei, Vermeulen, Roel, Byun, Hyang-Min, Wong, Jason Y Y, Bassig, Bryan A, Blechter, Batel, Duan, Huawei, Niu, Yong, Downward, George, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Meng, Tao, Bin, Ping, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, Seow, Wei Jie, Hu, Wei, Dai, Yufei, Vermeulen, Roel, Byun, Hyang-Min, Wong, Jason Y Y, Bassig, Bryan A, Blechter, Batel, Duan, Huawei, Niu, Yong, Downward, George, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Meng, Tao, Bin, Ping, Hosgood, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2022

14. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Abstract

A cross-sectional study of 54 male diesel engine exhaust (DEE)-exposed workers from an engine testing facility and a comparison group of 55 male unexposed controls was conducted in China. The association between occupational setting with high DEE exposure levels and Alu repeat copy number was investigated. Alu retroelements are repetitive DNA sequences that can multiply and compromise genomic stability. There is some evidence linking altered Alu repeats to cancer and elevated mortality risks. Personal air samples were assessed for elemental carbon, a DEE surrogate, using NIOSH Method 5040. Quantitative PCR was used to measure Alu repeat copy number relative to albumin (Alb) single-gene copy number in leucocyte DNA. DEE-exposed workers had a higher average Alu/Alb ratio than the unexposed controls. A positive exposure–response relationship (p=0.02) was observed. The Alu/Alb ratio was highest among workers exposed to the top tertile of DEE versus the unexposed controls. These findings suggest that DEE exposure may contribute to genomic instability.

Published
2021

15. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

16. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

17. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

18. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

19. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

20. Elevated Alu retroelement copy number among workers exposed to diesel engine exhaust

Author

IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Wong, Jason Y Y, Cawthon, Richard, Dai, Yufei, Vermeulen, Roel, Bassig, Bryan A, Hu, Wei, Duan, Huawei, Niu, Yong, Downward, George S, Leng, Shuguang, Ji, Bu-Tian, Fu, Wei, Xu, Jun, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ren, Dianzhi, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Hosgood Iii, H Dean, Silverman, Debra T, Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2021

21. The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure

Author

Chen, Shen, Li, Daochuan, Zhang, Haiyan, Yu, Dianke, Chen, Rui, Zhang, Bin, Tan, Yafei, Niu, Yong, Duan, Huawei, Mai, Bixian, Chen, Shejun, Yu, Jianzhen, Luan, Tiangang, Chen, Liping, Xing, Xiumei, Li, Qiong, Xiao, Yongmei, Dong, Guang Hui, Niu, Yujie, Aschner, Michael, Zhang, Rong, Zheng, Yuxin, Chen, Wen, Chen, Shen, Li, Daochuan, Zhang, Haiyan, Yu, Dianke, Chen, Rui, Zhang, Bin, Tan, Yafei, Niu, Yong, Duan, Huawei, Mai, Bixian, Chen, Shejun, Yu, Jianzhen, Luan, Tiangang, Chen, Liping, Xing, Xiumei, Li, Qiong, Xiao, Yongmei, Dong, Guang Hui, Niu, Yujie, Aschner, Michael, Zhang, Rong, Zheng, Yuxin, and Chen, Wen

Abstract

To assess the carcinogenic potential of PM2.5 exposure, we developed a cell-based experimental protocol to examine the cell transformation activity of PM2.5 samples from different regions in China. The seasonal ambient PM2.5 samples were collected from three megacities, Beijing (BJ), Wuhan (WH), and Guangzhou (GZ), from November 2016 to October 2017. The mean concentrations of PM2.5 were much higher in the winter season (BJ: 109.64 μg/m3, WH: 79.99 μg/m3, GZ: 49.99 μg/m3) than that in summer season (BJ: 42.40 μg/m3, WH: 25.82 μg/m3, GZ: 19.82 μg/m3). The organic extracts (OE) of PM2.5 samples from combined summer (S) (June, July, August) or winter (W) (November, December, January) seasons were subjected to characterization of chemical components. We treated human bronchial epithelial (HBE) cells expressing CYP1A1 (HBE-1A1) with PM2.5 samples at doses ranging from 0 to 100 μg/mL (0, 1.563, 3.125, 6.25, 12.5, 25, 50, 100 μg/mL) and determined the phenotype of malignant cell transformation. A dose-response relationship was analyzed by benchmark dose (BMD) modeling, and the potential were indicated by BMDL10. The order of the carcinogenic risk of seasonal PM2.5 samples from high to low was BJ-W, WH-W, GZ-W, WH-S, BJ-S, and GZ-S. Notably, we found that the alteration in the lung cancer-related biomarkers, KRAS, PTEN, p53, c-Myc, PCNA, pAKT/AKT, and pERK/ERK was congruent with the activity of cell transformation and the content of specific components of polycyclic aromatic hydrocarbon (PAHs) bound to PM2.5. Taken together, we have successfully developed a cell-based alternative model for the evaluation of potent carcinogenicity upon long-term PM2.5 exposure. © 2019 The Authors

Published
2019

22. Occupational exposure to diesel engine exhaust and serum cytokine levels

Author

dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, Zheng, Yuxin, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, and Zheng, Yuxin

Published
2018

23. Occupational exposure to diesel engine exhaust and serum cytokine levels

Author

dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, Zheng, Yuxin, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, and Zheng, Yuxin

Published
2018

24. Occupational exposure to diesel engine exhaust and serum cytokine levels

Author

dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, Zheng, Yuxin, dIRAS RA-I&I RA, One Health Chemisch, dIRAS RA-2, Dai, Yufei, Ren, Dianzhi, Bassig, Bryan A., Vermeulen, Roel, Hu, Wei, Niu, Yong, Duan, Huawei, Ye, Meng, Meng, Tao, Xu, Jun, Li, Ping, Shen, Meili, Yang, Jufang, Fu, Wei, Meliefste, Kees, Silverman, Debra T., Rothman, Nathaniel, Lan, Qing, and Zheng, Yuxin

Published
2018

25. Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China

Author

LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2017

26. Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China

Author

LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2017

27. Occupational exposure to diesel engine exhaust and alterations in immune/inflammatory markers: a cross-sectional molecular epidemiology study in China

Author

LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, Lan, Qing, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Bassig, Bryan A., Dai, Yufei, Vermeulen, Roel, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Shiels, Meredith S, Kemp, Troy J, Pinto, Ligia A, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Wong, Jason Y Y, Li, Ping, Hosgood, H. Dean, Hildesheim, Allan, Silverman, Debra T., Rothman, Nathaniel, Zheng, Yuxin, and Lan, Qing

Published
2017

28. Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets

Author

Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, Zheng, Yuxin, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, and Zheng, Yuxin

Abstract

The International Agency for Research on Cancer has classified carbon black (CB) as a possible (Group 2B) human carcinogen. Given that most CB manufacturing processes result in the emission of various types of chemicals, it is uncertain if the adverse health effects that have been observed in CB-exposed workers are related to CB specifically or are due to other exposures. To address this issue, we conducted a cross-sectional molecular epidemiology study in China of 106 male factory workers who were occupationally exposed to pure CB and 112 unexposed male workers frequency-matched by age and smoking status from the same geographic region. Repeated personal exposure measurements were taken in workers before biological sample collection. Peripheral blood from all workers was used for the complete blood cell count and lymphocyte subsets analysis. Compared to unexposed workers, eosinophil counts in workers exposed to CB were increased by 30.8% (P = 0.07) after adjusting for potential confounders. When stratified by smoking status, statistically significant differences in eosinophils between CB exposed and unexposed workers were only present among never smokers (P = 0.040). Smoking is associated with alterations in various cell counts; however, no significant interaction between CB exposure and smoking status for any cell counts was observed. Given that inflammation, characterized in part by elevated eosinophils in peripheral blood, may be associated with increased cancer risk, our findings provide new biologic insights into the potential relationship between CB exposure and lung carcinogenesis. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

29. Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, Zheng, Yuxin, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, and Zheng, Yuxin

Published
2016

30. Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, Zheng, Yuxin, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, and Zheng, Yuxin

Published
2016

31. Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, Zheng, Yuxin, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, dIRAS RA-I&I RA, Dai, Yufei, Niu, Yong, Duan, Huawei, Bassig, Bryan A, Ye, Meng, Zhang, Xiao, Meng, Tao, Bin, Ping, Jia, Xiaowei, Shen, Meili, Zhang, Rong, Hu, Wei, Yang, Xiaofa, Vermeulen, Roel, Silverman, Debra, Rothman, Nathaniel, Lan, Qing, Yu, Shanfa, and Zheng, Yuxin

Published
2016

32. Occupational exposure to diesel engine exhaust and alterations in lymphocyte subsets

Author

Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, Rothman, Nathaniel, Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, and Rothman, Nathaniel

Abstract

BACKGROUND: The International Agency for Research on Cancer recently classified diesel engine exhaust (DEE) as a Group I carcinogen based largely on its association with lung cancer. However, the exposure-response relationship is still a subject of debate and the underlying mechanism by which DEE causes lung cancer in humans is not well understood.METHODS: We conducted a cross-sectional molecular epidemiology study in a diesel engine truck testing facility of 54 workers exposed to a wide range of DEE (ie, elemental carbon air levels, median range: 49.7, 6.1-107.7 µg/m(3)) and 55 unexposed comparable controls.RESULTS: The total lymphocyte count (p=0.00044) and three of the four major lymphocyte subsets (ie, CD4+ T cells (p=0.00019), CD8+ T cells (p=0.0058) and B cells (p=0.017)) were higher in exposed versus control workers and findings were highly consistent when stratified by smoking status. In addition, there was evidence of an exposure-response relationship between elemental carbon and these end points (ptrends<0.05), and CD4+ T cell levels were significantly higher in the lowest tertile of DEE exposed workers compared to controls (p=0.012).CONCLUSIONS: Our results suggest that DEE exposure is associated with higher levels of cells that play a key role in the inflammatory process, which is increasingly being recognised as contributing to the aetiology of lung cancer.IMPACT: This study provides new insights into the underlying mechanism of DEE carcinogenicity.

Published
2015

33. Occupational exposure to diesel engine exhaust and alterations in lymphocyte subsets

Author

Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, Rothman, Nathaniel, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, and Rothman, Nathaniel

Published
2015

34. Occupational exposure to diesel engine exhaust and alterations in lymphocyte subsets

Author

Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, Rothman, Nathaniel, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, and Rothman, Nathaniel

Published
2015

35. Occupational exposure to diesel engine exhaust and alterations in lymphocyte subsets

Author

Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, Rothman, Nathaniel, Risk Assessment, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), LS IRAS EEPI ME (Milieu epidemiologie), Lan, Qing, Vermeulen, Roel, Dai, Yufei, Ren, Dianzhi, Hu, Wei, Duan, Huawei, Niu, Yong, Xu, Jun, Fu, Wei, Meliefste, Kees, Zhou, Baosen, Yang, Jufang, Ye, Meng, Jia, Xiaowei, Meng, Tao, Bin, Ping, Kim, Christopher, Bassig, Bryan A, Hosgood, H Dean, Silverman, Debra, Zheng, Yuxin, and Rothman, Nathaniel

Published
2015

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