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Ye QD, Liao XL, Fu P, Dou JY, Chen K, Jiang H. Onco Targets Ther. 2016;9:6953–6963. The Editor and Publisher of OncoTargets and Therapy wish to retract the published article. Concerns were raised regarding the alleged duplication of images in Figures 2 and 3, and the alleged duplication of western blot bands in Figure 5 with those from other articles. Specifically, Figure 2Ba, HL60 cells, PCA (1 µM), appears to have been duplicated with the same image for Figure 3Ba, U937 cells, PCA (1 µM), and Figure 3Ba, U937 cells, PCA (2 µM), which has been flipped. The GAPDH western blot image in Figure 5E, appears to have been duplicated with the same GAPDH image used in Figure 8C from Yu et al, 2017 (https://doi.org/10.3892/ijmm.2017.3098); Figure 2A from Zou et al, 2017 (https://doi.org/10.1038/s41598-017-00686-8); Figure 6B from Guo et al, 2017 (https://doi.org/10.1038/s41598-017-01832-y); Figure 3a from Jiang et al, 2017 (https://doi.org/10.1038/emm.2017.41) and Figure 2B from Miao et al, 2016 (https://doi.org/10.3727/096504016X14685034103671). The authors did not respond to our queries and as we cannot verify the validity of the published work, we are therefore retracting the article and have notified the authors of this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Qidong Ye,1 Pan Fu,2 Jiaying Dou,2 Nina Wang2 1Department of Pediatrics, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo, People’s Republic of China; 2Department of Hematology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China Introduction: Acute myeloid leukemia (AML) is a common malignancy of the hematopoietic system. In bone marrow samples of AML patients, PDIA3 expression was higher than that in the samples of healthy controls. We aimed at exploring the effect of PDIA3 siRNA on proliferation, apoptosis, migration, and invasion of AML HL-60 and HEL cells.Materials and methods: RT-PCR was performed to identify PDIA3 expression. Cell proliferation was assessed by MTT. Flow cytometry analysis and transwell were used to detect cell apoptosis, migration and invasion. Gene set enrich-ment analysis (GSEA) was employed to explore the PDIA 3-associated pathways in AML. Western blotting was used for protein expression detection.Results: PDIA3 siRNA significantly inhibited the proliferation of AML cells at 24 and 48 h. PDIA3 siRNA notably enhanced the percentage of apoptotic cells. The migration and invasion abilities of HL-60 and HEL cells in the PDIA3 siRNA group were significantly suppressed compared with those in the control and siNC groups. GSEA of the Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways could be correlated with PDIA3 expression; this was further confirmed in AML cells by Western blotting. MAPK signaling was also blocked by PDIA3 siRNA. Conclusion: PDIA3 siRNA effectively enhanced apoptosis, and suppressed proliferation, invasion, and migration of AML cells by regulating oxidative phosphorylation and amino sugar and nucleotide sugar metabolism pathways, and MAPK signaling, which can provide novel therapeutic targets for AML. Keywords: PDIA3, acut

This paper has been retracted. Ye QD, Liao XL, Fu P, Dou JY, Chen K, Jiang H. Onco Targets Ther. 2016;9:6953–6963. The Editor and Publisher of OncoTargets and Therapy wish to retract the published article. Concerns were raised regarding the alleged duplication of images in Figures 2 and 3, and the alleged duplication of western blot bands in Figure 5 with those from other articles. Specifically, Figure 2Ba, HL60 cells, PCA (1 µM), appears to have been duplicated with the same image for Figure 3Ba, U937 cells, PCA (1 µM), and Figure 3Ba, U937 cells, PCA (2 µM), which has been flipped. The GAPDH western blot image in Figure 5E, appears to have been duplicated with the same GAPDH image used in Figure 8C from Yu et al, 2017 (https://doi.org/10.3892/ijmm.2017.3098); Figure 2A from Zou et al, 2017 (https://doi.org/10.1038/s41598-017-00686-8); Figure 6B from Guo et al, 2017 (https://doi.org/10.1038/s41598-017-01832-y); Figure 3a from Jiang et al, 2017 (https://doi.org/10.1038/emm.2017.41) and Figure 2B from Miao et al, 2016 (https://doi.org/10.3727/096504016X14685034103671). The authors did not respond to our queries and as we cannot verify the validity of the published work, we are therefore retracting the article and have notified the authors of this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.