Search

Using the YOLO algorithm in the accident detection and reporting system is a creative way to improve road safety. The YOLO (You Only Look Once) approach is an advanced object recognition system that can recognise and locate items in real-time video feeds. The technology uses the YOLO algorithm to identify accidents and alert emergency services, reducing response times and increasing the chance of lifesaving. Object detection and an alarm system are the two key parts of the suggested system. The YOLO method is used by the object detection component to find accidents in live video broadcasts. To correctly recognise accidents, the system is taught using a module of accident photographs. The alert system is turned on when an accident is found. The alert system notifies the emergency services of the accident's location and a brief summary of what happened. A wireless communication network is used to relay this information to the emergency services, speeding up reaction times and raising the possibility of lifesaving. The system has undergone testing on an accident module and photos, and the results are encouraging. The YOLO algorithm was shown to have an accuracy of about 94 in detecting accidents, and the alarm system's response time was under a few seconds. To increase traffic safety and lower the number of accidents, the system can be installed at busy intersections, highways, and other high-risk areas. A possible strategy to increase traffic safety is to implement crash detection and warning systems utilizing deep learning's YOLO technique. In real-time video streams, the system can precisely identify accidents and notify emergency services, speeding up response times and improving the likelihood of lifesaving.

Using the YOLO algorithm in the accident detection and reporting system is a creative way to improve road safety. The YOLO (You Only Look Once) approach is an advanced object recognition system that can recognise and locate items in real-time video feeds. The technology uses the YOLO algorithm to identify accidents and alert emergency services, reducing response times and increasing the chance of lifesaving. Object detection and an alarm system are the two key parts of the suggested system. The YOLO method is used by the object detection component to find accidents in live video broadcasts. To correctly recognise accidents, the system is taught using a module of accident photographs. The alert system is turned on when an accident is found. The alert system notifies the emergency services of the accident's location and a brief summary of what happened. A wireless communication network is used to relay this information to the emergency services, speeding up reaction times and raising the possibility of lifesaving. The system has undergone testing on an accident module and photos, and the results are encouraging. The YOLO algorithm was shown to have an accuracy of about 94 in detecting accidents, and the alarm system's response time was under a few seconds. To increase traffic safety and lower the number of accidents, the system can be installed at busy intersections, highways, and other high-risk areas. A possible strategy to increase traffic safety is to implement crash detection and warning systems utilizing deep learning's YOLO technique. In real-time video streams, the system can precisely identify accidents and notify emergency services, speeding up response times and improving the likelihood of lifesaving.

Background: Asthma is a respiratory disease that affects your lungs. In asthma, airways of the lungs constrict due to swelling and accumulation of mucus. Newer remedies known as targeted therapies have evolved as a result of advancements in medical research, greatly relieving these patients. The biologics used in the severe allergic asthma is Omalizumab. Purpose: Demonstrating the clinical efficacy of Omalizumab in severe allergic asthma by reducing exacerbation rates and increasing quality of life. Methods: A single-arm prospective pilot study of omalizumab in severe allergic asthma was conducted in a tertiary care hospital for the duration of one year with the help of Asthma Quality of Life Questionnaire (AQLQ). Results and discussions: On an initial dose of omalizumab of 150 mg in 2 vials subcutaneously every month for 6 months, among our study population, 45% of the patients had their symptoms improve more than they had with prior medications. Results show that the patient's overall score has improved by nearly 50%. This shows that omalizumab improves the quality of life of severe asthmatic patients. Conclusion: Patients treated with omalizumab have improved their clinical conditions and quality of life, and it can prevent exacerbations by controlling the severity of the condition. Keywords: AQLQ, Allergic asthma, Exacerbation, IgE, Omalizumab.

Background: Asthma is a respiratory disease that affects your lungs. In asthma, airways of the lungs constrict due to swelling and accumulation of mucus. Newer remedies known as targeted therapies have evolved as a result of advancements in medical research, greatly relieving these patients. The biologics used in the severe allergic asthma is Omalizumab. Purpose: Demonstrating the clinical efficacy of Omalizumab in severe allergic asthma by reducing exacerbation rates and increasing quality of life. Methods: A single-arm prospective pilot study of omalizumab in severe allergic asthma was conducted in a tertiary care hospital for the duration of one year with the help of Asthma Quality of Life Questionnaire (AQLQ). Results and discussions: On an initial dose of omalizumab of 150 mg in 2 vials subcutaneously every month for 6 months, among our study population, 45% of the patients had their symptoms improve more than they had with prior medications. Results show that the patient's overall score has improved by nearly 50%. This shows that omalizumab improves the quality of life of severe asthmatic patients. Conclusion: Patients treated with omalizumab have improved their clinical conditions and quality of life, and it can prevent exacerbations by controlling the severity of the condition. Keywords: AQLQ, Allergic asthma, Exacerbation, IgE, Omalizumab.

In Guillain-Barré syndrome, the body's immune system attacks part of the peripheral nervous system. We present a case series of four cases with different variants. Three cases have been diagnosed with nerve conduction studies, one case with positive lumbar puncture test with albumino-cytological dissociation. Each patient was treated with Intravenous Immunoglobulin (IVIG) and improved clinically. This series is being delivered in order to clinically inform individuals on the early diagnosis of GBS and its management. Keywords: GBS, IVIG, Lower limb, Lumbar puncture test, Nerve conduction studies, Radiating pain.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

Concrete is the most widely used construction material in civil engineering industry because of its high structural strength and stability. For low- and middle-income people very difficult to construct the buildings. Now-a-days, in the market the fine aggregate rates are increasing rapidly due to the depletion of River sands. Quarry Dust and Granite Powder are among the powder wastes generated by the industry. To overcome from this crisis, partial replacement of fine aggregate by quarry dust and granite powder in concrete. This research is carried out in two phases. In the first phase, the mix of M25 cubes is made by normal convectional concrete to determine the maximum compressive strength. In the second phase, Fine aggregates is partially replaced by Quarry Dust and Granite Powder by 50%, 60% and 50%,40% as fine aggregates as constant to determine the compressive strength as 3,7 and 28 days. This research evaluates the strength and strength efficiency factors of hardened concrete by partially replacing of fine aggregates by various percentages of Quarry Dust and Granite Powder for M25 grade of concrete at different ages.

The Gram-negative bacterium Shigella flexneri is the causative agent of shigellosis, a diarrhoeal disease also known as bacillary dysentery. S. flexneri infects the colonic and rectal epithelia of its primate host and induces a cascade of inflammatory responses that culminates in the destruction of the host intestinal lining. Molecular characterization of host-pathogen interactions in this infection has been challenging due to the host specificity of S. flexneri strains, as it strictly infects humans and non-human primates. Recent studies have shown that S. flexneri infects the soil dwelling nematode Caenorhabditis elegans, however, the interactions between S. flexneri and C. elegans at the cellular level and the cause of nematode death are unknown. Here we attempt to gain insight into the complex host-pathogen interactions between S. flexneri and C. elegans. Using transmission electron microscopy, we show that live S. flexneri cells accumulate in the nematode intestinal lumen, produce outer membrane vesicles and invade nematode intestinal cells. Using two-dimensional differential in-gel electrophoresis we identified host proteins that are differentially expressed in response to S. flexneri infection. Four of the identified genes, aco-1, cct-2, daf-19 and hsp-60, were knocked down using RNAi and ACO-1, CCT-2 and DAF-19, which were identified as up-regulated in response to S. flexneri infection, were found to be involved in the infection process. aco-1 RNAi worms were more resistant to S. flexneri infection, suggesting S. flexneri-mediated disruption of host iron homeostasis. cct-2 and daf-19 RNAi worms were more susceptible to infection, suggesting that these genes are induced as a protective mechanism by C. elegans. These observations further our understanding of the processes involved in S. flexneri infection of C. elegans, which is immensely beneficial to the routine use of this new in vivo model to study S. flexneri pathogenesis.

S. flexneri strains, most frequently linked with endemic outbreaks of shigellosis, invade the colonic and rectal epithelium of their host and cause severe tissue damage. Here we have attempted to elucidate the contribution of the periplasmic enzyme, L-asparaginase (AnsB) to the pathogenesis of S. flexneri. Using a reverse genetic approach we found that ansB mutants showed reduced adherence to epithelial cells in vitro and attenuation in two in vivo models of shigellosis, the Caenorhabditis elegans and the murine pulmonary model. To investigate how AnsB affects bacterial adherence, we compared the proteomes of the ansB mutant with its wild type parental strain using two dimensional differential in-gel electrophoresis and identified the outer membrane protein, OmpA as up-regulated in ansB mutant cells. Bacterial OmpA, is a prominent outer membrane protein whose activity has been found to be required for bacterial pathogenesis. Overexpression of OmpA in wild type S. flexneri serotype 3b resulted in decreasing the adherence of this virulent strain, suggesting that the up-regulation of OmpA in ansB mutants contributes to the reduced adherence of this mutant strain. The data presented here is the first report that links the metabolic enzyme AnsB to S. flexneri pathogenesis.