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Background: Asthma is a respiratory disease that affects your lungs. In asthma, airways of the lungs constrict due to swelling and accumulation of mucus. Newer remedies known as targeted therapies have evolved as a result of advancements in medical research, greatly relieving these patients. The biologics used in the severe allergic asthma is Omalizumab. Purpose: Demonstrating the clinical efficacy of Omalizumab in severe allergic asthma by reducing exacerbation rates and increasing quality of life. Methods: A single-arm prospective pilot study of omalizumab in severe allergic asthma was conducted in a tertiary care hospital for the duration of one year with the help of Asthma Quality of Life Questionnaire (AQLQ). Results and discussions: On an initial dose of omalizumab of 150 mg in 2 vials subcutaneously every month for 6 months, among our study population, 45% of the patients had their symptoms improve more than they had with prior medications. Results show that the patient's overall score has improved by nearly 50%. This shows that omalizumab improves the quality of life of severe asthmatic patients. Conclusion: Patients treated with omalizumab have improved their clinical conditions and quality of life, and it can prevent exacerbations by controlling the severity of the condition. Keywords: AQLQ, Allergic asthma, Exacerbation, IgE, Omalizumab.

Background: Asthma is a respiratory disease that affects your lungs. In asthma, airways of the lungs constrict due to swelling and accumulation of mucus. Newer remedies known as targeted therapies have evolved as a result of advancements in medical research, greatly relieving these patients. The biologics used in the severe allergic asthma is Omalizumab. Purpose: Demonstrating the clinical efficacy of Omalizumab in severe allergic asthma by reducing exacerbation rates and increasing quality of life. Methods: A single-arm prospective pilot study of omalizumab in severe allergic asthma was conducted in a tertiary care hospital for the duration of one year with the help of Asthma Quality of Life Questionnaire (AQLQ). Results and discussions: On an initial dose of omalizumab of 150 mg in 2 vials subcutaneously every month for 6 months, among our study population, 45% of the patients had their symptoms improve more than they had with prior medications. Results show that the patient's overall score has improved by nearly 50%. This shows that omalizumab improves the quality of life of severe asthmatic patients. Conclusion: Patients treated with omalizumab have improved their clinical conditions and quality of life, and it can prevent exacerbations by controlling the severity of the condition. Keywords: AQLQ, Allergic asthma, Exacerbation, IgE, Omalizumab.

In Guillain-Barré syndrome, the body's immune system attacks part of the peripheral nervous system. We present a case series of four cases with different variants. Three cases have been diagnosed with nerve conduction studies, one case with positive lumbar puncture test with albumino-cytological dissociation. Each patient was treated with Intravenous Immunoglobulin (IVIG) and improved clinically. This series is being delivered in order to clinically inform individuals on the early diagnosis of GBS and its management. Keywords: GBS, IVIG, Lower limb, Lumbar puncture test, Nerve conduction studies, Radiating pain.

The accessibility of content for all has been a key goal of the Web since its conception. However, true accessibility -- access to relevant content in the global context -- has been elusive for reasons that extend beyond physical accessibility issues. Among them are the spoken languages, literacy levels, expertise, and culture. These issues are highly significant, since information may not reach those who are the most in need of it. For example, the minimum wage laws that are published in legalese on government sites and the low-literate and immigrant populations. While some organizations and volunteers work on bridging such gaps by creating and disseminating alternative versions of such content, Web scale solutions much be developed to take advantage of its distributed dissemination capabilities. This work examines content accessibility from the perspective of inclusiveness. For this purpose, a human in the loop approach for renarrating Web content is proposed, where a renarrator creates an alternative narrative of some Web content with the intent of extending its reach. A renarration relates some Web content with an alternative version by means of transformations like simplification, elaboration, translation, or production of audio and video material. This work presents a model and a basic architecture for supporting renarrations along with various scenarios. We also discuss the potentials of the W3C specification for Web Annotation Data Model towards a more inclusive and decentralized social web.

Objective: To develop an improved HPLC method for estimation of phyllanthin and hypophyllanthin in Phyllanthus amarus. Materials and methods: An Isocratic, reversed phase (RP) HPLC procedure has been adopted using a mixture of pH 2.8 Phosphate buffer and acetonitrile as mobile phase, CN column as stationary phase and UV detector. Results: The developed method shows high resolution (R = 1.9), accuracy and reproducibility. Conclusion: The method developed is relatively better in terms of separation than the previously reported methods.

Objective: To develop an improved HPLC method for estimation of phyllanthin and hypophyllanthin in Phyllanthus amarus. Materials and methods: An Isocratic, reversed phase (RP) HPLC procedure has been adopted using a mixture of pH 2.8 Phosphate buffer and acetonitrile as mobile phase, CN column as stationary phase and UV detector. Results: The developed method shows high resolution (R = 1.9), accuracy and reproducibility. Conclusion: The method developed is relatively better in terms of separation than the previously reported methods.

The abstract mathematical theory of partial differential equations (PDEs) is formulated in terms of manifolds, scalar fields, tensors, and the like, but these algebraic structures are hardly recognizable in actual PDE solvers. The general aim of the Sophus programming style is to bridge the gap between theory and practice in the domain of PDE solvers. Its main ingredients are a library of abstract datatypes corresponding to the algebraic structures used in the mathematical theory and an algebraic expression style similar to the expression style used in the mathematical theory. Because of its emphasis on abstract datatypes, Sophus is most naturally combined with object-oriented languages or other languages supporting abstract datatypes. The resulting source code patterns are beyond the scope of current compiler optimizations, but are sufficiently specific for a dedicated source-to-source optimizer. The limited, domain-specific, character of Sophus is the key to success here. This kind of optimization has been tested on computationally intensive Sophus style code with promising results. The general approach may be useful for other styles and in other application domains as well., Comment: 19 pages. Submitted to Scientific Programming