Search

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI., The study was also supported by funding from the Academy of Finland to J.P.P. (grant no. 17379) and a grant from Maire Taponen Foundation to J.P.P.

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

Environmental flows (e-flows) aim to mitigate the threat of altered hydrological regimes in river systems and connected waterbodies and are an important component of integrated strategies to address multiple threats to freshwater biodiversity. Expanding and accelerating implementation of e-flows can support river conservation and help to restore the biodiversity and resilience of hydrologically altered and water-stressed rivers and connected freshwater ecosystems. While there have been significant developments in e-flow science, assessment, and societal acceptance, implementation of e-flows within water resource management has been slower than required and geographically uneven. This review explores critical factors that enable successful e-flow implementation and biodiversity outcomes in particular, drawing on 13 case studies and the literature. It presents e-flow implementation as an adaptive management cycle enabled by 10 factors: legislation and governance, financial and human resourcing, stakeholder engagement and co-production of knowledge, collaborative monitoring of ecological and social-economic outcomes, capacity training and research, exploration of trade-offs among water users, removing or retrofitting water infrastructure to facilitate e-flows and connectivity, and adaptation to climate change. Recognising that there may be barriers and limitations to the full and effective enablement of each factor, the authors have identified corresponding options and generalizable recommendations for actions to overcome prominent constraints, drawing on the case studies and wider literature. The urgency of addressing flow-related freshwater biodiversity loss demands collaborative networks to train and empower a new generation of e-flow practitioners equipped with the latest tools and insights to lead adaptive environmental water management globally. Mainstreaming e-flows within conservation planning, integrated water resource management, river restoration strategies

Natural Resources and Resilience (NRR), A Digital Twin is a virtual representation of an object or system that spans its lifecycle, is updated from real-time data, and uses simulation, machine learning and reasoning to help decision making. The use of Digital Twins to aid decision-makers to make realtime decisions in complex systems is a growing field, with large potential for water system management. The CGIAR Initiative on Digital Innovation is developing a prototype Digital Twin for the Limpopo River Basin in close combination with stakeholders, to enable better management and conservation of this imperilled natural resource upon which millions of people depend. The Digital Twin will provide an attractive and easy-to-use interface for users to intuitively understand large volumes of data and modelling results for timely management decisions, and to simulate the impact of these decisions on the complex river basin ecosystem before they are put into action. This includes an artificial intelligence (AI) tool to interrogate and visualize key actionable data and forecasts. It will be developed in a phased approach according to stakeholder priorities.

Acute traumatic brain injury (TBI) is associated with substantial abnormalities in lipid biology, including changes in the structural lipids that are present in the myelin in the brain. We investigated the relationship between traumatic microstructural changes in white matter from magnetic resonance imaging (MRI) and quantitative lipidomic changes from blood serum. The study cohort included 103 patients from the Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Diffusion tensor fitting generated fractional anisotropy (FA) and mean diffusivity (MD) maps for the MRI scans while ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry was applied to analyze the lipidome. Increasing severity of TBI was associated with higher MD and lower FA values, which scaled with different lipidomic signatures. There appears to be consistent patterns of lipid changes associating with the specific microstructure changes in the CNS white matter, but also regional specificity, suggesting that blood-based lipidomics may provide an insight into the underlying pathophysiology of TBI.

Digital tools, particularly specialised decision support systems (DSSs), can be utilized to assist in the complex process of brownfield redevelopment. Existing brownfield DSSs typically focus on site-specific, late-stage applications, and socioeconomic factors are often overlooked. In this paper, we present a novel DSS aimed at providing support for early-stage, city region-scale brownfield land use planning and redevelopment. The proposed DSS is a prototype WebGIS application that enables land use planners and other brownfield regeneration professionals to examine a region and a set of sites during the initial planning phase for brownfield redevelopment. The DSS includes three bespoke modules comprising: (1) Land Use Potential (residential, commercial, and public open space), (2) risks posed by contamination and geotechnical hazards, (3) data pertinent to brownfield economic viability assessments. We outline a use case for this DSS, developed through comprehensive user-requirements gathering, and subsequently describe the techniques employed to construct the DSS modules and user interface. Finally, we present the results of user testing, wherein case-study stakeholders assessed the DSS. The feedback obtained during user testing aided in the identification of areas for improvement with regard to the functionality, usability, and effectiveness of the DSS in supporting decision-makers. The feedback was utilized to implement iterative improvements to the DSS and to plan future developments for the prototype DSS.

Background: The effects of cannabis are thought to be mediated by interactions between its constituents and the endocannabinoid system. Delta-9-tetrahydrocannabinol (THC) binds to central cannabinoid receptors, while cannabidiol (CBD) may influence endocannabinoid function without directly acting on cannabinoid receptors. We examined the effects of THC coadministered with different doses of CBD on plasma levels of endocannabinoids in healthy volunteers. Methods: In a randomized, double-blind, four-arm crossover study, healthy volunteers (n=46) inhaled cannabis vapor containing 10 mg THC plus either 0, 10, 20, or 30 mg CBD, in four experimental sessions. The median time between sessions was 14 days (IQR=20). Blood samples were taken precannabis inhalation and at 0-, 5-, 15-, and 90-min postinhalation. Plasma concentrations of THC, CBD, anandamide, 2-arachidonoylglycerol (2-AG), and related noncannabinoid lipids were measured using liquid chromatography-mass spectrometry. Results: Administration of cannabis induced acute increases in plasma concentrations of anandamide (+18.0%, 0.042 ng/mL [95%CI: 0.023-0.062]), and the noncannabinoid ethanolamides, docosatetraenylethanolamide (DEA; +35.8%, 0.012 ng/mL [95%CI: 0.008-0.016]), oleoylethanolamide (+16.1%, 0.184 ng/mL [95%CI: 0.076-0.293]), and N-arachidonoyl-L-serine (+25.1%, 0.011 ng/mL [95%CI: 0.004-0.017]) (p<0.05). CBD had no significant effect on the plasma concentration of anandamide, 2-AG or related noncannabinoid lipids at any of three doses used. Over the four sessions, there were progressive decreases in the preinhalation concentrations of anandamide and DEA, from 0.254 ng/mL [95%CI: 0.223-0.286] to 0.194 ng/mL [95%CI: 0.163-0.226], and from 0.039 ng/mL [95%CI: 0.032-0.045] to 0.027 ng/mL [95%CI: 0.020-0.034] (p<0.05), respectively. Discussion: THC induced acute increases in plasma levels of anandamide and noncannabinoid ethanolamides, but there was no evidence that these effects were influenced by the co, Funding agency:UK Research & Innovation (UKRI)Medical Research Council UK (MRC) MR/P006841/1

Cooking recipes are one of the most readily available kinds of procedural text. They consist of natural language instructions that can be challenging to interpret. In this paper, we propose a model to identify relevant information from recipes and generate a graph to represent the sequence of actions in the recipe. In contrast with other approaches, we use an unsupervised approach. We iteratively learn the graph structure and the parameters of a $\mathsf{GNN}$ encoding the texts (text-to-graph) one sequence at a time while providing the supervision by decoding the graph into text (graph-to-text) and comparing the generated text to the input. We evaluate the approach by comparing the identified entities with annotated datasets, comparing the difference between the input and output texts, and comparing our generated graphs with those generated by state of the art methods.

We leverage convex and bilevel optimization techniques to develop a general gradient-based parameter learning framework for neural-symbolic (NeSy) systems. We demonstrate our framework with NeuPSL, a state-of-the-art NeSy architecture. To achieve this, we propose a smooth primal and dual formulation of NeuPSL inference and show learning gradients are functions of the optimal dual variables. Additionally, we develop a dual block coordinate descent algorithm for the new formulation that naturally exploits warm-starts. This leads to over 100x learning runtime improvements over the current best NeuPSL inference method. Finally, we provide extensive empirical evaluations across 8 datasets covering a range of tasks and demonstrate our learning framework achieves up to a 16% point prediction performance improvement over alternative learning methods.

Decoding the core of procedural texts, exemplified by cooking recipes, is crucial for intelligent reasoning and instruction automation. Procedural texts can be comprehensively defined as a sequential chain of steps to accomplish a task employing resources. From a cooking perspective, these instructions can be interpreted as a series of modifications to a food preparation, which initially comprises a set of ingredients. These changes involve transformations of comestible resources. For a model to effectively reason about cooking recipes, it must accurately discern and understand the inputs and outputs of intermediate steps within the recipe. Aiming to address this, we present a new corpus of cooking recipes enriched with descriptions of intermediate steps of the recipes that explicate the input and output for each step. We discuss the data collection process, investigate and provide baseline models based on T5 and GPT-3.5. This work presents a challenging task and insight into commonsense reasoning and procedural text generation., Comment: The data is available at: https://github.com/adiallo07/PizzaCommonsense

We propose a dialogue system that enables heart failure patients to inquire about salt content in foods and help them monitor and reduce salt intake. Addressing the lack of specific datasets for food-based salt content inquiries, we develop a template-based conversational dataset. The dataset is structured to ask clarification questions to identify food items and their salt content. Our findings indicate that while fine-tuning transformer-based models on the dataset yields limited performance, the integration of Neuro-Symbolic Rules significantly enhances the system's performance. Our experiments show that by integrating neuro-symbolic rules, our system achieves an improvement in joint goal accuracy of over 20% across different data sizes compared to naively fine-tuning transformer-based models., Comment: Accepted in CL4Health workshop in LREC-COLING'24

The story of the orphan Oliver, who runs away from the workhouse only to be taken in by a den of thieves, shocked readers when it was first published. Dickens's tale of childhood innocence beset by evil depicts the dark criminal underworld of a London peopled by vivid and memorable characters - the arch-villain Fagin, the artful Dodger, the menacing Bill Sikes and the prostitute Nancy. Combining elements of Gothic Romance, the Newgate Novel and popular melodrama, Dickens created an entirely newkind of fiction, scathing in its indictment of a cruel society, and pervaded by an unforgettable sense of threat and mystery.

David Copperfield is the novel Dickens regarded as his 'favourite child' and is considered his most autobiographical. As David recounts his experience from childhood to the discovery of his vocation as a successful novelist, Dickens draws openly and revealingly on his own life. Among the gloriously vivid cast of characters are David's tyrannical stepfather, Mr Murdstone; his brilliant, but ultimately unworthy, school-friend Steerforth; his formidable aunt, Betsey Trotwood; the eternally humble, yet treacherous Uriah Heep; frivolous, enchanting Dora; and the magnificently impecunious Micawber, one of literature's great comic creations.

Here you will find all the Christmas books and stories written by Dickens. The Christmas Books: - A Christmas Carol - The Chimes - The Cricket on the Hearth - The Battle of Life - The Haunted Man and the Ghost's Bargain The Christmas Stories: - A Christmas Tree - What Christmas is as we Grow Older - The Poor Relation's Story - The Child's Story - The Schoolboy's Story - Nobody's Story - The Seven Poor Travellers - The Holly-Tree - Wreck of the Golden Mary - The Perils of Certain English Prisoners - Going into Society - A Message From the Sea - Tom Tiddler's Ground - Somebody's Luggage - Mrs. Lirriper's Lodgings - Mrs. Lirriper's Legacy - Doctor Marigold - Mugby Junction - No Thoroughfare

As the interminable case of Jarndyce and Jarndyce grinds its way through the Court of Chancery, it draws together a disparate group of people: Ada and Richard Clare, whose inheritance is gradually being devoured by legal costs; Esther Summerson, a ward of court, whose parentage is a source of deepening mystery; the menacing lawyer Tulkinghorn; the determined sleuth Inspector Bucket; and even Jo, the destitute little crossing-sweeper. A savage, but often comic, indictment of a society that is rotten to the core, Bleak House is one of Dickens's most ambitious novels, with a range that extends from the drawing rooms of the aristocracy to the poorest of London slums.

Charles Dickens (1812-1870) was an English writer and social critic. He created some of the world’s best-known fictional characters and is regarded by many as the greatest novelist of the Victorian era. His works enjoyed unprecedented popularity during his lifetime, and by the 20th century critics and scholars had recognized him as a literary genius. His natural inclinations toward drama and the macabre made him a brilliant teller of supernatural tales such as “The Signal-Man,” “To Be Read at Dusk,” “The Hanged Man’s Bride,” “The Mothers’ Eyes,” and “Captain Murderer and the Devil’s Bargain.”

The French Revolution comes to vivid life in Charles Dickens's famous novel about the best of times and the worst of times... The storming of the Bastille…the death carts with their doomed human cargo…the swift drop of the guillotine blade—this is the French Revolution that Charles Dickens vividly captures in his famous work A Tale of Two Cities. With dramatic eloquence, he brings to life a time of terror and treason, a starving people rising in frenzy and hate to overthrow a corrupt and decadent regime. With insight and compassion, Dickens casts his novel of unforgettable scenes with some memorable characters: the sinister Madame Defarge, knitting her patterns of death; the gentle Lucie Manette, unswerving in her devotion to her broken father; Charles Darnay, the lover with a secret past; and dissolute Sydney Carton, whose unlikely heroism gives his life meaning.

Ebenezer Scrooge is a mean, miserable, bitter old man with no friends. One cold Christmas Eve, three ghosts take him on a scary journey to show him the error of his nasty ways. By visiting his past, present and future, Scrooge learns to love Christmas and the people all around him.

The Greatest Christmas Stories of All Time is a treasury of short fiction by great writers of the past two centuries — from Dickens, Dostoyevsky and Tolstoy to Willa Cather, Damon Runyon and Beatrix Potter. As a literary subject, Christmas has inspired everything from intimate domestic dramas to fanciful flights of the imagination, and the full range of its expression is represented in this wonderfully engaging anthology.

Few first novels have created as much popular excitement as The Pickwick Papers - a comic masterpiece that catapulted its twenty-four-year-old author to immediate fame. Readers were captivated by the adventures of the poet Snodgrass, the lover Tupman, the sportsman Winkle and, above all, by that quintessentially English Quixote, Mr Pickwick, and his cockney Sancho Panza, Sam Weller. From the hallowed turf of Dingley Dell Cricket Club to the unholy fracas of the Eatanswill election, via the Fleet debtors' prison, characters and incidents spring to life from Dickens's pen, to form an enduringly popular work of ebullient humour and literary invention.

Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

Few first novels have created as much popular excitement as The Pickwick Papers - a comic masterpiece that catapulted its twenty-four-year-old author to immediate fame. Readers were captivated by the adventures of the poet Snodgrass, the lover Tupman, the sportsman Winkle and, above all, by that quintessentially English Quixote, Mr Pickwick, and his cockney Sancho Panza, Sam Weller. From the hallowed turf of Dingley Dell Cricket Club to the unholy fracas of the Eatanswill election, via the Fleet debtors' prison, characters and incidents spring to life from Dickens's pen, to form an enduringly popular work of ebullient humour and literary invention.

The Greatest Christmas Stories of All Time is a treasury of short fiction by great writers of the past two centuries — from Dickens, Dostoyevsky and Tolstoy to Willa Cather, Damon Runyon and Beatrix Potter. As a literary subject, Christmas has inspired everything from intimate domestic dramas to fanciful flights of the imagination, and the full range of its expression is represented in this wonderfully engaging anthology.

The Greatest Christmas Stories of All Time is a treasury of short fiction by great writers of the past two centuries — from Dickens, Dostoyevsky and Tolstoy to Willa Cather, Damon Runyon and Beatrix Potter. As a literary subject, Christmas has inspired everything from intimate domestic dramas to fanciful flights of the imagination, and the full range of its expression is represented in this wonderfully engaging anthology.

Few first novels have created as much popular excitement as The Pickwick Papers - a comic masterpiece that catapulted its twenty-four-year-old author to immediate fame. Readers were captivated by the adventures of the poet Snodgrass, the lover Tupman, the sportsman Winkle and, above all, by that quintessentially English Quixote, Mr Pickwick, and his cockney Sancho Panza, Sam Weller. From the hallowed turf of Dingley Dell Cricket Club to the unholy fracas of the Eatanswill election, via the Fleet debtors' prison, characters and incidents spring to life from Dickens's pen, to form an enduringly popular work of ebullient humour and literary invention.

Few first novels have created as much popular excitement as The Pickwick Papers - a comic masterpiece that catapulted its twenty-four-year-old author to immediate fame. Readers were captivated by the adventures of the poet Snodgrass, the lover Tupman, the sportsman Winkle and, above all, by that quintessentially English Quixote, Mr Pickwick, and his cockney Sancho Panza, Sam Weller. From the hallowed turf of Dingley Dell Cricket Club to the unholy fracas of the Eatanswill election, via the Fleet debtors' prison, characters and incidents spring to life from Dickens's pen, to form an enduringly popular work of ebullient humour and literary invention.

The Greatest Christmas Stories of All Time is a treasury of short fiction by great writers of the past two centuries — from Dickens, Dostoyevsky and Tolstoy to Willa Cather, Damon Runyon and Beatrix Potter. As a literary subject, Christmas has inspired everything from intimate domestic dramas to fanciful flights of the imagination, and the full range of its expression is represented in this wonderfully engaging anthology.

David Copperfield is the novel Dickens regarded as his 'favourite child' and is considered his most autobiographical. As David recounts his experience from childhood to the discovery of his vocation as a successful novelist, Dickens draws openly and revealingly on his own life. Among the gloriously vivid cast of characters are David's tyrannical stepfather, Mr Murdstone; his brilliant, but ultimately unworthy, school-friend Steerforth; his formidable aunt, Betsey Trotwood; the eternally humble, yet treacherous Uriah Heep; frivolous, enchanting Dora; and the magnificently impecunious Micawber, one of literature's great comic creations.

The story of the orphan Oliver, who runs away from the workhouse only to be taken in by a den of thieves, shocked readers when it was first published. Dickens's tale of childhood innocence beset by evil depicts the dark criminal underworld of a London peopled by vivid and memorable characters - the arch-villain Fagin, the artful Dodger, the menacing Bill Sikes and the prostitute Nancy. Combining elements of Gothic Romance, the Newgate Novel and popular melodrama, Dickens created an entirely newkind of fiction, scathing in its indictment of a cruel society, and pervaded by an unforgettable sense of threat and mystery.

The story of the orphan Oliver, who runs away from the workhouse only to be taken in by a den of thieves, shocked readers when it was first published. Dickens's tale of childhood innocence beset by evil depicts the dark criminal underworld of a London peopled by vivid and memorable characters - the arch-villain Fagin, the artful Dodger, the menacing Bill Sikes and the prostitute Nancy. Combining elements of Gothic Romance, the Newgate Novel and popular melodrama, Dickens created an entirely newkind of fiction, scathing in its indictment of a cruel society, and pervaded by an unforgettable sense of threat and mystery.

David Copperfield is the novel Dickens regarded as his 'favourite child' and is considered his most autobiographical. As David recounts his experience from childhood to the discovery of his vocation as a successful novelist, Dickens draws openly and revealingly on his own life. Among the gloriously vivid cast of characters are David's tyrannical stepfather, Mr Murdstone; his brilliant, but ultimately unworthy, school-friend Steerforth; his formidable aunt, Betsey Trotwood; the eternally humble, yet treacherous Uriah Heep; frivolous, enchanting Dora; and the magnificently impecunious Micawber, one of literature's great comic creations.

Charles Dickens (1812-1870) was an English writer and social critic. He created some of the world’s best-known fictional characters and is regarded by many as the greatest novelist of the Victorian era. His works enjoyed unprecedented popularity during his lifetime, and by the 20th century critics and scholars had recognized him as a literary genius. His natural inclinations toward drama and the macabre made him a brilliant teller of supernatural tales such as “The Signal-Man,” “To Be Read at Dusk,” “The Hanged Man’s Bride,” “The Mothers’ Eyes,” and “Captain Murderer and the Devil’s Bargain.”

Ebenezer Scrooge is a mean, miserable, bitter old man with no friends. One cold Christmas Eve, three ghosts take him on a scary journey to show him the error of his nasty ways. By visiting his past, present and future, Scrooge learns to love Christmas and the people all around him.

As the interminable case of Jarndyce and Jarndyce grinds its way through the Court of Chancery, it draws together a disparate group of people: Ada and Richard Clare, whose inheritance is gradually being devoured by legal costs; Esther Summerson, a ward of court, whose parentage is a source of deepening mystery; the menacing lawyer Tulkinghorn; the determined sleuth Inspector Bucket; and even Jo, the destitute little crossing-sweeper. A savage, but often comic, indictment of a society that is rotten to the core, Bleak House is one of Dickens's most ambitious novels, with a range that extends from the drawing rooms of the aristocracy to the poorest of London slums.

The French Revolution comes to vivid life in Charles Dickens's famous novel about the best of times and the worst of times... The storming of the Bastille…the death carts with their doomed human cargo…the swift drop of the guillotine blade—this is the French Revolution that Charles Dickens vividly captures in his famous work A Tale of Two Cities. With dramatic eloquence, he brings to life a time of terror and treason, a starving people rising in frenzy and hate to overthrow a corrupt and decadent regime. With insight and compassion, Dickens casts his novel of unforgettable scenes with some memorable characters: the sinister Madame Defarge, knitting her patterns of death; the gentle Lucie Manette, unswerving in her devotion to her broken father; Charles Darnay, the lover with a secret past; and dissolute Sydney Carton, whose unlikely heroism gives his life meaning.

Here you will find all the Christmas books and stories written by Dickens. The Christmas Books: - A Christmas Carol - The Chimes - The Cricket on the Hearth - The Battle of Life - The Haunted Man and the Ghost's Bargain The Christmas Stories: - A Christmas Tree - What Christmas is as we Grow Older - The Poor Relation's Story - The Child's Story - The Schoolboy's Story - Nobody's Story - The Seven Poor Travellers - The Holly-Tree - Wreck of the Golden Mary - The Perils of Certain English Prisoners - Going into Society - A Message From the Sea - Tom Tiddler's Ground - Somebody's Luggage - Mrs. Lirriper's Lodgings - Mrs. Lirriper's Legacy - Doctor Marigold - Mugby Junction - No Thoroughfare

Charles Dickens (1812-1870) was an English writer and social critic. He created some of the world’s best-known fictional characters and is regarded by many as the greatest novelist of the Victorian era. His works enjoyed unprecedented popularity during his lifetime, and by the 20th century critics and scholars had recognized him as a literary genius. His natural inclinations toward drama and the macabre made him a brilliant teller of supernatural tales such as “The Signal-Man,” “To Be Read at Dusk,” “The Hanged Man’s Bride,” “The Mothers’ Eyes,” and “Captain Murderer and the Devil’s Bargain.”

The French Revolution comes to vivid life in Charles Dickens's famous novel about the best of times and the worst of times... The storming of the Bastille…the death carts with their doomed human cargo…the swift drop of the guillotine blade—this is the French Revolution that Charles Dickens vividly captures in his famous work A Tale of Two Cities. With dramatic eloquence, he brings to life a time of terror and treason, a starving people rising in frenzy and hate to overthrow a corrupt and decadent regime. With insight and compassion, Dickens casts his novel of unforgettable scenes with some memorable characters: the sinister Madame Defarge, knitting her patterns of death; the gentle Lucie Manette, unswerving in her devotion to her broken father; Charles Darnay, the lover with a secret past; and dissolute Sydney Carton, whose unlikely heroism gives his life meaning.

As the interminable case of Jarndyce and Jarndyce grinds its way through the Court of Chancery, it draws together a disparate group of people: Ada and Richard Clare, whose inheritance is gradually being devoured by legal costs; Esther Summerson, a ward of court, whose parentage is a source of deepening mystery; the menacing lawyer Tulkinghorn; the determined sleuth Inspector Bucket; and even Jo, the destitute little crossing-sweeper. A savage, but often comic, indictment of a society that is rotten to the core, Bleak House is one of Dickens's most ambitious novels, with a range that extends from the drawing rooms of the aristocracy to the poorest of London slums.

Ebenezer Scrooge is a mean, miserable, bitter old man with no friends. One cold Christmas Eve, three ghosts take him on a scary journey to show him the error of his nasty ways. By visiting his past, present and future, Scrooge learns to love Christmas and the people all around him.

Here you will find all the Christmas books and stories written by Dickens. The Christmas Books: - A Christmas Carol - The Chimes - The Cricket on the Hearth - The Battle of Life - The Haunted Man and the Ghost's Bargain The Christmas Stories: - A Christmas Tree - What Christmas is as we Grow Older - The Poor Relation's Story - The Child's Story - The Schoolboy's Story - Nobody's Story - The Seven Poor Travellers - The Holly-Tree - Wreck of the Golden Mary - The Perils of Certain English Prisoners - Going into Society - A Message From the Sea - Tom Tiddler's Ground - Somebody's Luggage - Mrs. Lirriper's Lodgings - Mrs. Lirriper's Legacy - Doctor Marigold - Mugby Junction - No Thoroughfare

David Copperfield is the novel Dickens regarded as his 'favourite child' and is considered his most autobiographical. As David recounts his experience from childhood to the discovery of his vocation as a successful novelist, Dickens draws openly and revealingly on his own life. Among the gloriously vivid cast of characters are David's tyrannical stepfather, Mr Murdstone; his brilliant, but ultimately unworthy, school-friend Steerforth; his formidable aunt, Betsey Trotwood; the eternally humble, yet treacherous Uriah Heep; frivolous, enchanting Dora; and the magnificently impecunious Micawber, one of literature's great comic creations.

The story of the orphan Oliver, who runs away from the workhouse only to be taken in by a den of thieves, shocked readers when it was first published. Dickens's tale of childhood innocence beset by evil depicts the dark criminal underworld of a London peopled by vivid and memorable characters - the arch-villain Fagin, the artful Dodger, the menacing Bill Sikes and the prostitute Nancy. Combining elements of Gothic Romance, the Newgate Novel and popular melodrama, Dickens created an entirely newkind of fiction, scathing in its indictment of a cruel society, and pervaded by an unforgettable sense of threat and mystery.

As the interminable case of Jarndyce and Jarndyce grinds its way through the Court of Chancery, it draws together a disparate group of people: Ada and Richard Clare, whose inheritance is gradually being devoured by legal costs; Esther Summerson, a ward of court, whose parentage is a source of deepening mystery; the menacing lawyer Tulkinghorn; the determined sleuth Inspector Bucket; and even Jo, the destitute little crossing-sweeper. A savage, but often comic, indictment of a society that is rotten to the core, Bleak House is one of Dickens's most ambitious novels, with a range that extends from the drawing rooms of the aristocracy to the poorest of London slums.

Ebenezer Scrooge is a mean, miserable, bitter old man with no friends. One cold Christmas Eve, three ghosts take him on a scary journey to show him the error of his nasty ways. By visiting his past, present and future, Scrooge learns to love Christmas and the people all around him.

The French Revolution comes to vivid life in Charles Dickens's famous novel about the best of times and the worst of times... The storming of the Bastille…the death carts with their doomed human cargo…the swift drop of the guillotine blade—this is the French Revolution that Charles Dickens vividly captures in his famous work A Tale of Two Cities. With dramatic eloquence, he brings to life a time of terror and treason, a starving people rising in frenzy and hate to overthrow a corrupt and decadent regime. With insight and compassion, Dickens casts his novel of unforgettable scenes with some memorable characters: the sinister Madame Defarge, knitting her patterns of death; the gentle Lucie Manette, unswerving in her devotion to her broken father; Charles Darnay, the lover with a secret past; and dissolute Sydney Carton, whose unlikely heroism gives his life meaning.

Charles Dickens (1812-1870) was an English writer and social critic. He created some of the world’s best-known fictional characters and is regarded by many as the greatest novelist of the Victorian era. His works enjoyed unprecedented popularity during his lifetime, and by the 20th century critics and scholars had recognized him as a literary genius. His natural inclinations toward drama and the macabre made him a brilliant teller of supernatural tales such as “The Signal-Man,” “To Be Read at Dusk,” “The Hanged Man’s Bride,” “The Mothers’ Eyes,” and “Captain Murderer and the Devil’s Bargain.”

Here you will find all the Christmas books and stories written by Dickens. The Christmas Books: - A Christmas Carol - The Chimes - The Cricket on the Hearth - The Battle of Life - The Haunted Man and the Ghost's Bargain The Christmas Stories: - A Christmas Tree - What Christmas is as we Grow Older - The Poor Relation's Story - The Child's Story - The Schoolboy's Story - Nobody's Story - The Seven Poor Travellers - The Holly-Tree - Wreck of the Golden Mary - The Perils of Certain English Prisoners - Going into Society - A Message From the Sea - Tom Tiddler's Ground - Somebody's Luggage - Mrs. Lirriper's Lodgings - Mrs. Lirriper's Legacy - Doctor Marigold - Mugby Junction - No Thoroughfare