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Objective: The visual system often is affected in patients with preeclampsia and even more in cases of eclampsia, a life-threatening pregnancy complication. Symptoms include blurred vision and deterioration of visual acuity. Pregnancy can also affect pre-existing conditions, such as diabetic retinopathy. In this case series, we describe three patients with the same underlying condition, i.e. (pre)eclampsia who experienced acute visual disturbance whereas the final diagnosis was different: disseminated intravascular coagulopathy (DIC), posterior reversible encephalopathy syndrome (PRES), and diabetic retinopathy.Methods and results: All patients underwent a thorough slit lamp examination and ocular coherence tomography (OCT). All patients presented with acute impaired vision and subretinal fluid and-/or fibrin. Conclusions: These cases highlight the importance of early involvement of ophthalmologists when pregnant women complain about visual disorders.

Microencapsulating pancreatic islets in immunoprotective alginate hydrogels is a promising strategy for treatment of type 1 diabetes. However, this strategy is limited by inflammation and hypoxia mediated oxidative stress, due to encapsulation and the hydrogel itself, leading to impaired insulin secretion and limited short and long term cell survival. Herein, the antioxidant effect of fucoidan, an algae derived polysaccharide, on beta cells, and its positive effects on encapsulated beta cell viability and function is presented. Fucoidan from Fucus vesiculosus (FF) exhibits a high total antioxidant capacity, and free radical scavenging activity, and is able to significantly alleviate intracellular oxidative stress in rat insolinoma beta cells (INS1E). In addition, FF significantly increases insulin secretion in a dose- and time-dependent manner. When FF is incorporated in ultrapure alginate used for microencapsulation of primary rat islets, both viability and glucose responsiveness of rat islets in these socalled Fucogel microcapsules (Fucocaps) are found to be significantly higher compared to islets encapsulated in alginate alone. Similar results are obtained with INS1E pseudoislets and neonatal pig islets. Fucocaps can provide a redox-modulatory niche and an immune barrier for islets and beta cells in the same time leading to significantly improved survival and endocrine function by mitigating oxidative strees.

Microencapsulating pancreatic islets in immunoprotective hydrogels is a promising cellular therapy for type 1 diabetes. However, a major factor limiting the encapsulated islet efficacy is inflammatory/hypoxia mediated oxidative stress, resulting in impaired insulin secretion and ultimately islet cell death. Fucoidan, a natural polysaccharide, possess strong anti-oxidant properties but its effects on beta cells and encapsulation is unknown. Here, we assessed the anti-oxidant effect of fucoidan on beta cells and its effect on encapsulated beta cell viability and function, using fucoidans extracted from two different seaweeds, namely Fucus vesiculosus (FF) and Ascophyllum nodosum (FA). FF exhibited significantly higher total antioxidant capacity and free radical scavenging activity, significantly alleviating intracellular oxidative stress in INS1E beta cells, when compared to FA. In presence of high glucose, FF fucoidans significantly increased insulin secretion both in a dose- and time-dependent manner. Viability, ATP levels and high-glucose responsiveness of rat islets encapsulated in fucoidan-containing hydrogel (Fucogel) microcapsules were significantly higher compared to those encapsulated in pure alginate microcapsules. Similar results were obtained with INS1E pseudo-islets and neonatal pig islets. Fucogels can provide a redox-modulatory niche and an immune barrier in the same time, presenting as an outstanding biomaterial for bioengineered immunoprotective beta cell replacement devices.

Microencapsulating pancreatic islets in immunoprotective alginate hydrogels is a promising strategy for treatment of type 1 diabetes. However, this strategy is limited by inflammation and hypoxia mediated oxidative stress, due to encapsulation and the hydrogel itself, leading to impaired insulin secretion and limited short and long term cell survival. Herein, the antioxidant effect of fucoidan, an algae derived polysaccharide, on beta cells, and its positive effects on encapsulated beta cell viability and function is presented. Fucoidan from Fucus vesiculosus (FF) exhibits a high total antioxidant capacity, and free radical scavenging activity, and is able to significantly alleviate intracellular oxidative stress in rat insolinoma beta cells (INS1E). In addition, FF significantly increases insulin secretion in a dose- and time-dependent manner. When FF is incorporated in ultrapure alginate used for microencapsulation of primary rat islets, both viability and glucose responsiveness of rat islets in these socalled Fucogel microcapsules (Fucocaps) are found to be significantly higher compared to islets encapsulated in alginate alone. Similar results are obtained with INS1E pseudoislets and neonatal pig islets. Fucocaps can provide a redox-modulatory niche and an immune barrier for islets and beta cells in the same time leading to significantly improved survival and endocrine function by mitigating oxidative strees.

Stomatological examination Of 60 children aged 12-15 years with diabetes type I, undergoing inpatient treatment at the endocrinological departments of Regional Children‘ s Clinical Hospital, and 30 absolutely healthy children of the same age on the base of surgical and children dentistry department at school №22, has been carried out. Various changes of local immunity has been established in children with diabetes type I that developed against background of metabolic disorders in diabetes.

Objetivos: La Educación Terapéutica en Diabetes (ETD) influye en su la variabilidad pronóstica. El rigor del profesional de la salud debería ser el mismo tanto prescribiendo fármacos como dando normas de conducta. El objetivo del presente estudio fue revisar la literatura reciente relacionada con la diabetes, la educación terapéutica y los autocuidados. Metodología: Se realizó una búsqueda bibliográfica en las bases de datos PudMed, Cuiden, Ibecs, Lilacs, Scielo y Enfispo en febrero de 2012. El límite temporal fue de 5 años. Se buscaron las palabras clave en título, abstract y como descriptores. Resultados: Se identificaron un total de 194 artículos. El 29% se incluyeron en el estudio (n=54). El 64.4% de los trabajos fueron localizados en PudMed (n=124); no se encontró ningún resultado en la base de datos CUIDEN. El principal motivo de exclusión fue que los artículos no estaban relacionados directamente con el tema de la revisión en el 32.8% de los casos (n=65). Los trabajos con carácter cualitativo fueron los más abundantes (n=12). Conclusiones: La implantación de intervenciones educativas innovadoras centradas en los autocuidados parece tener beneficios sobre los pacientes diabéticos, mejorando el manejo de la enfermedad o las cifras de glucosa y hemoglobina glicosilada, facilitando el empowerment de los pacientes o diminuyendo el control paterno en diabéticos tipo I. Es necesaria más investigación experimental que aclare qué tipo de intervenciones educativas presentan mayores ventajas y beneficios para las personas diabéticas en diferentes contextos., Aims: The therapeutic education in Diabetes (NTDS) influences in its variability prognostic, highlighting the fact that the rigour of the health professional should be the same both prescribing drugs as giving rules of conduct. The objective of the present study was to review the recent literature related to diabetes, therapeutic education and self-care. Methodology: A literature search was conducted PudMed, care, Ibecs, Lilacs, Scielo and Enfispo databases in February 2012. The time limit was 5 years and searched keywords in title and abstract as well as how descriptors. Findings: A total of 194 articles were identified. The 29 were included in the study (n=54). The 64.4 works were located in PudMed (n=124); not found any result in the database take care. The main reason for exclusion was that the articles were not directly related with the subject of the review in the cases (n=65) 32.8. Work with qualitative character were the most abundant (n=12). Conclusions: The implementation of innovative educational interventions focused on self-care seems to have benefits on diabetic patients, improving the management of the disease or the levels of glucose and glycosylated hemoglobin, facilitating the empowerment of patients or weaker parental control in diabetics type I. Further experimental research to clarify what kind of educational interventions have greater advantages and benefits for people with diabetes in different contexts is needed.

La Educación Terapéutica en Diabetes (ETD) influye en su la variabilidad pronóstica. El rigor del profesional de la salud debería ser el mismo tanto prescribiendo fármacos como dando normas de conducta. El objetivo del presente estudio fue revisar la literatura reciente relacionada con la diabetes, la educación terapéutica y los autocuidados., The therapeutic education in Diabetes (NTDS) influences in its variability prognostic, highlighting the fact that the rigour of the health professional should be the same both prescribing drugs as giving rules of conduct. The objective of the present study was to review the recent literature related to diabetes, therapeutic education and self-care.

Objetivos: La Educación Terapéutica en Diabetes (ETD) influye en su la variabilidad pronóstica. El rigor del profesional de la salud debería ser el mismo tanto prescribiendo fármacos como dando normas de conducta. El objetivo del presente estudio fue revisar la literatura reciente relacionada con la diabetes, la educación terapéutica y los autocuidados. Metodología: Se realizó una búsqueda bibliográfica en las bases de datos PudMed, Cuiden, Ibecs, Lilacs, Scielo y Enfispo en febrero de 2012. El límite temporal fue de 5 años. Se buscaron las palabras clave en título, abstract y como descriptores. Resultados: Se identificaron un total de 194 artículos. El 29% se incluyeron en el estudio (n=54). El 64.4% de los trabajos fueron localizados en PudMed (n=124); no se encontró ningún resultado en la base de datos CUIDEN. El principal motivo de exclusión fue que los artículos no estaban relacionados directamente con el tema de la revisión en el 32.8% de los casos (n=65). Los trabajos con carácter cualitativo fueron los más abundantes (n=12). Conclusiones: La implantación de intervenciones educativas innovadoras centradas en los autocuidados parece tener beneficios sobre los pacientes diabéticos, mejorando el manejo de la enfermedad o las cifras de glucosa y hemoglobina glicosilada, facilitando el empowerment de los pacientes o diminuyendo el control paterno en diabéticos tipo I. Es necesaria más investigación experimental que aclare qué tipo de intervenciones educativas presentan mayores ventajas y beneficios para las personas diabéticas en diferentes contextos., Aims: The therapeutic education in Diabetes (NTDS) influences in its variability prognostic, highlighting the fact that the rigour of the health professional should be the same both prescribing drugs as giving rules of conduct. The objective of the present study was to review the recent literature related to diabetes, therapeutic education and self-care. Methodology: A literature search was conducted PudMed, care, Ibecs, Lilacs, Scielo and Enfispo databases in February 2012. The time limit was 5 years and searched keywords in title and abstract as well as how descriptors. Findings: A total of 194 articles were identified. The 29 were included in the study (n=54). The 64.4 works were located in PudMed (n=124); not found any result in the database take care. The main reason for exclusion was that the articles were not directly related with the subject of the review in the cases (n=65) 32.8. Work with qualitative character were the most abundant (n=12). Conclusions: The implementation of innovative educational interventions focused on self-care seems to have benefits on diabetic patients, improving the management of the disease or the levels of glucose and glycosylated hemoglobin, facilitating the empowerment of patients or weaker parental control in diabetics type I. Further experimental research to clarify what kind of educational interventions have greater advantages and benefits for people with diabetes in different contexts is needed.