1. Associations between brainstem volume and Alzheimer’s disease pathology in middle-aged individuals of the Framingham Heart Study
- Author
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UCL - SSS/IONS/NEUR - Clinical Neuroscience, Heidi I.L. Jacobs, Adrienne O’Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Hanseeuw, Bernard, Emma Thibault1, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Heidi I.L. Jacobs, Adrienne O’Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Hanseeuw, Bernard, Emma Thibault1, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, and Sudha Seshadri
- Abstract
The brainstem is among the first regions to accumulate Alzheimer’s disease-related hyperphosphorylated tau pathology during aging. We aimed to examine associations between brainstem volume and neocortical beta-amyloid or tau pathology in 271 middle-aged clinically normal individuals of the Framingham Heart Study (FHS) who underwent MRI and PET imaging. Lower volume of the medulla, pons or midbrain was associated with greater neocortical amyloid burden. No associations were detected between brainstem volumes and tau deposition. Ourr esults support the hypothesis that lower brainstem volumes are associated with initial AD-related processes and may signal preclinical AD pathology.
- Published
- 2022