1. Endoscopic full-thickness resection vs. endoscopic submucosal dissection of residual/recurrent colonic lesions on scars: a retrospective Italian and Japanese comparative study
- Author
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Barbaro, Federico, Papparella, Luigi Giovanni, Chiappetta, Michele Francesco, Ciuffini, Cristina, Fukuchi, Takehide, Hamanaka, Jun, Quero, Giuseppe, Pecere, Silvia, Gibiino, Giulia, Petruzziello, Lucio, Maeda, Shin, Hirasawa, Kingo, Costamagna, Guido, Quero, Giuseppe (ORCID:0000-0002-0001-9479), Costamagna, Guido (ORCID:0000-0002-8100-2731), Barbaro, Federico, Papparella, Luigi Giovanni, Chiappetta, Michele Francesco, Ciuffini, Cristina, Fukuchi, Takehide, Hamanaka, Jun, Quero, Giuseppe, Pecere, Silvia, Gibiino, Giulia, Petruzziello, Lucio, Maeda, Shin, Hirasawa, Kingo, Costamagna, Guido, Quero, Giuseppe (ORCID:0000-0002-0001-9479), and Costamagna, Guido (ORCID:0000-0002-8100-2731)
- Abstract
Background and aimsEndoscopic treatment of recurrent/residual colonic lesions on scars is a challenging procedure. In this setting, endoscopic submucosal dissection (ESD) is considered the first choice, despite a significant rate of complications. Endoscopic full-thickness resection (eFTR) has been shown to be well-tolerated and effective for these lesions. The aim of this study is to conduct a comparison of outcomes for resection of such lesions between ESD and eFTR in an Italian and a Japanese referral center.MethodsFrom January 2018 to July 2020, we retrospectively enrolled patients with residual/recurrent colonic lesions, 20 treated by eFTR in Italy and 43 treated by ESD in Japan. The primary outcome was to compare the two techniques in terms of en-bloc and R0-resection rates, whereas complications, time of procedure, and outcomes at 3-month follow-up were evaluated as secondary outcomes.ResultsR0 resection rate was not significantly different between the two groups [18/20 (90%) and 41/43 (95%); P= 0.66]. En-bloc resection was 100% in both groups. No significant difference was found in the procedure time (54 min vs. 61 min; P= 0.9). There was a higher perforation rate in the ESD group [11/43 (26%) vs. 0/20 (0%); P= 0.01]. At the 3-month follow-up, two lesions relapsed in the eFTR cohort and none in the ESD cohort (P= 0.1).ConclusioneFTR is a safer, as effective and equally time-consuming technique compared with ESD for the treatment of residual/recurrent colonic lesions on scars and could become an alternative therapeutic option for such lesions.
- Published
- 2024