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Precast concrete multistory buildings are used in an attempt to optimize the available construction space and reduce costs. However, little is known about predicting their capacity in a brittle response mode due to the sudden loss of a critical element that could induce a Progressive Collapse Scenario. Therefore, the National Institute for Standards and Technology (NIST) developed an explicit approach in the design of precast concrete systems that is intended to mitigate a progressive collapse by enhancing the rotational capacity of joints and the robustness of the structural system. A full-scale experiment was conducted to investigate the structural performance of a prototype design under a column-removal scenario. The test assembly frame, consisting of three columns and two beams, was subjected to a displacement controlled vertical force acting at the center to characterize the failure modes and collapse mechanisms. Brittle-failures of critical structural elements were observed and significantly impacted the performance.