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Adult T-cell leukemia/lymphoma (ALLT) is a mature T-cell neoplasm frequently composed of highly pleomorphic lymphoid cells. Although there are different clinical subtypes described, it usually presents as a disseminated disease with a poor prognosis, with generalized involvement of lymph nodes, skin, hypercalcaemia and expression in peripheral blood. It is caused by the human retrovirus HTLV-1, infection necessary but not enough to develop disease, being observed more frequently in endemic areas. We present 2 cases of adult patients, with different clinical features, with the aim of highlighting the importance of diagnostic suspicion, the value of complementary tests available, new therapeutic alternatives and effective strategies to prevent viral transmission, La leucemia/linfoma de células T del adulto (LLTA) es una neoplasia de células T maduras compuesta frecuentemente de células linfoides altamente pleomórficas. Aunque existen diferentes formas clínicas descritas, suele presentarse como una enfermedad diseminada y de pobre pronóstico, con compromiso generalizado de ganglios linfáticos, piel, hipercalcemia y expresión en la sangre periférica. Es causada por el retrovirus humano HTLV-1, infección necesaria pero no suficiente para desarrollar enfermedad, siendo observada con mayor frecuencia en las áreas endémicas. A continuación, presentamos 2 casos de pacientes adultos, con distintas manifestaciones clínicas, con el objetivo de destacar la importancia de la sospecha diagnóstica, el valor de los exámenes complementarios disponibles, y la necesidad de nuevas alternativas terapéuticas y estrategias efectivas de prevención de la transmisión viral.

Although the metastasic breast cancer is still an incurable disease, recent advances have increased signifcantly the time to progression and the overall survival. However, too much information has been produced in the last 2 years, so a well-based guideline is a valuable document in treatment decision making. The SEOM guidelines are intended to make evidence-based recommendations on how to manage patients with advanced and recurrent breast cancer to achieve the best patient outcomes based on a rational use of the currently available therapies. To assign a level of certainty and a grade of recommendation the United States Preventive Services Task Force guidelines methodology was selected as reference.