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Die vorliegende Arbeit findet in sehr frühgeborenen Erwachsenen verkleinerte Volumina von Hypothalamuskernen, die an der Regulation des Körpergewichtes beteiligt sind. Veränderte Körpergewichtsentwicklungen nach Frühgeburt korrelieren mit Volumenveränderungen in relevanten Hypothalamuskernen im Erwachsenenalter., The present work demonstrates lower volumes of hypothalamus subunits involved in body weight control in very premature born adults. Altered body weight trajectories after premature birth correlate with volumetric changes of relevant hypothalamus nuclei in adulthood.

Mice as prey animals display a phenomenal sense of smell and thus rely heavily on this sensory modality for social communication and defenses from predators. One of the mouse’s olfactory subsystems is the vomeronasal organ, a specialized organ for the detection of environmental chemical stimuli. This organ plays a central role in semio-chemical detection which has become vital for the survival of the mouse and proliferation of the species. This knowledge then leads to the question of how mice respond to varying levels of intensity of predator cues with the input from this organ. Using cat odor as a predator cue, mouse defensive and non-defensive behavioral responses were compared after exposure to fresh versus 4-hour old odor. Overall, we measured the significant reduction in defensive freezing behavior in response to the 4-hour old cat saliva in male mice as well as the reduction of non-defensive interaction behavior. Female mice expressed no shift in defensive responses between the fresh and old saliva but maintained reduction of non-defensive interaction as well. Mice have shown to exhibit varying defensive responses to predator cues and perhaps may have greater abilities to respond to non-imminent predator threat.

Mice as prey animals display a phenomenal sense of smell and thus rely heavily on this sensory modality for social communication and defenses from predators. One of the mouse’s olfactory subsystems is the vomeronasal organ, a specialized organ for the detection of environmental chemical stimuli. This organ plays a central role in semio-chemical detection which has become vital for the survival of the mouse and proliferation of the species. This knowledge then leads to the question of how mice respond to varying levels of intensity of predator cues with the input from this organ. Using cat odor as a predator cue, mouse defensive and non-defensive behavioral responses were compared after exposure to fresh versus 4-hour old odor. Overall, we measured the significant reduction in defensive freezing behavior in response to the 4-hour old cat saliva in male mice as well as the reduction of non-defensive interaction behavior. Female mice expressed no shift in defensive responses between the fresh and old saliva but maintained reduction of non-defensive interaction as well. Mice have shown to exhibit varying defensive responses to predator cues and perhaps may have greater abilities to respond to non-imminent predator threat.

Mice as prey animals display a phenomenal sense of smell and thus rely heavily on this sensory modality for social communication and defenses from predators. One of the mouse’s olfactory subsystems is the vomeronasal organ, a specialized organ for the detection of environmental chemical stimuli. This organ plays a central role in semio-chemical detection which has become vital for the survival of the mouse and proliferation of the species. This knowledge then leads to the question of how mice respond to varying levels of intensity of predator cues with the input from this organ. Using cat odor as a predator cue, mouse defensive and non-defensive behavioral responses were compared after exposure to fresh versus 4-hour old odor. Overall, we measured the significant reduction in defensive freezing behavior in response to the 4-hour old cat saliva in male mice as well as the reduction of non-defensive interaction behavior. Female mice expressed no shift in defensive responses between the fresh and old saliva but maintained reduction of non-defensive interaction as well. Mice have shown to exhibit varying defensive responses to predator cues and perhaps may have greater abilities to respond to non-imminent predator threat.

In der Dissertation wird der Aufbau tiefengeothermischer Heizwerke mit besonderer Beachtung der hydraulischen und regelungstechnischen Eigenschaften und Anforderungen vorgestellt. Weiterführend wird eine speziell an die Randbedingungen der Tiefengeothermie angepasste, hybride Speichereinbindung aus verschiedenen hydraulischen Ansätzen nach dem Stand der Technik entwickelt. Die neuartige Konzeption ermöglicht eine deutlich höhere Anzahl an Speicherzyklen und optimiert somit die Effizienz geothermischer Heizwerke., In this doctoral thesis, the common design of deep geothermal heating plants with focus on the properties and requirements of the hydraulic design and the control system is presented. Furthermore, a new hydraulic concept, the hybrid concept is presented. This concept has been developed from different hydraulic solutions according to different state of the art concepts with particular consideration of the requirements of geothermal heating plants. The new hydraulic concept allows a significantly higher number of storage cycles. Thereby the efficiency of geothermal heating plants can be optimized.

Background: Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial. Methods: An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients. Results: The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine), and vincristine regimen has not imposed itself as the gold-standard treatment after surgery, despite the results of the Radiation Therapy Oncology Group 9802 study. Temozolomide is largely used as first-line treatment after surgical resection for high-risk DLGG patients, or at progression. Conclusions: The heterogeneity in the management of patients with DLGG demonstrates that many questions regarding the postoperative strategy and the use of chemotherapy remain unanswered. Our survey reveals a high recruitment potential within the ELGGN for retrospective or prospective studies to generate new data regarding these issues.

Objective: Imaging studies in diffuse low-grade gliomas (DLGG) vary across centers. In order to establish a minimal core of imaging necessary for further investigations and clinical trials in the field of DLGG, we aimed to establish the status quo within specialized European centers. Methods: An online survey composed of 46 items was sent out to members of the European Low-Grade Glioma Network, the European Association of Neurosurgical Societies, the German Society of Neurosurgery and the Austrian Society of Neurosurgery. Results: A total of 128 fully completed surveys were received and analyzed. Most centers (n = 96, 75%) were academic and half of the centers (n = 64, 50%) adhered to a dedicated treatment program for DLGG. There were national differences regarding the sequences enclosed in MRI imaging and use of PET, however most included T1 (without and with contrast, 100%), T2 (100%) and TIRM or FLAIR (20, 98%). DWI is performed by 80% of centers and 61% of centers regularly performed PWI. Conclusion: A minimal core of imaging composed of T1 (w/wo contrast), T2, TIRM/FLAIR, PWI and DWI could be identified. All morphologic images should be obtained in a slice thickness of ≤ 3 mm. No common standard could be obtained regarding advanced MRI protocols and PET. Importance of the study: We believe that our study makes a significant contribution to the literature because we were able to determine similarities in numerous aspects of LGG imaging. Using the proposed "minimal core of imaging" in clinical routine will facilitate future cooperative studies.

In der Dissertation wird der Aufbau tiefengeothermischer Heizwerke mit besonderer Beachtung der hydraulischen und regelungstechnischen Eigenschaften und Anforderungen vorgestellt. Weiterführend wird eine speziell an die Randbedingungen der Tiefengeothermie angepasste, hybride Speichereinbindung aus verschiedenen hydraulischen Ansätzen nach dem Stand der Technik entwickelt. Die neuartige Konzeption ermöglicht eine deutlich höhere Anzahl an Speicherzyklen und optimiert somit die Effizienz geothermischer Heizwerke., In this doctoral thesis, the common design of deep geothermal heating plants with focus on the properties and requirements of the hydraulic design and the control system is presented. Furthermore, a new hydraulic concept, the hybrid concept is presented. This concept has been developed from different hydraulic solutions according to different state of the art concepts with particular consideration of the requirements of geothermal heating plants. The new hydraulic concept allows a significantly higher number of storage cycles. Thereby the efficiency of geothermal heating plants can be optimized.

[Verf.: Christian Franz Paullini], Verf. ermittelt

Nicht identisch mit Prod.-Nr. 1:069152U (unterschiedl. Umfang; dort: von Bl. ][7 verso mit einer weiterführenden Kustode "VII. Can-" auf Bl. ][][), Christiani Francisci Paullini Ilapa Curiosa

nunc ab Innumeris Sphalmatis vindicata, & Exterorum in gratiam, Latinitati donata, opera D. Christiani Francisci Paullini, Academici Curiosi, Schlüsselseiten aus dem Exemplar der ULB Halle: Ug 604 a, Paginierungsfehler: Sprung von S. 416 auf 447 (Bl. Ggg1r)

En la parte superior de la hoja encima del mapa: "Meyer's Zeitungs-Atlas" y en el derecho: "Nº 24", Inserta en el ángulo inferior derecho: "Plan von Madrid" / Gez. v . Hauptmann Radefeld. - 8 cm. de diámetro. -Escala de 40 pies castellanos "oder Leipziger Fuss.", Escala expresada también en: 36 leguas portuguesas y 30 millas geográficas, Márgenes graduados. Meridianos y paralelos dibujados formando cuadrícula. En el margen superior meridiano de origen: París; en el margen inferior meridiano de origen: Isla de Hierro. Relieve por normales. Hidrografía. Toponimia en alemán con nombres en español y portugués. Costas sombreadas por un fino rayado. Divisiones delimitadas por líneas de puntos, Mapa perteneciente a "Neuster Zeitungs Atlas. Alter und Neuer Erdkunde" de J. Meyer, Lugar y editor tomados del catálogo en línea de Union Catalog Northem Germany (GBV)

mitgetheilet von Kristian Frantz Paullini, Kupfert. zu Bd. 2: Zeit-Kürzende, Erbauliche Lust, Erschienen: 1 (1692). 1 (1693). 2 (1694). 1. (1695) - 3 (1697)

a Christiano Knaut, Med. D. Archiatro Anhaltino, Auch in: Paullini, Christian Franz: Gaeographia Curiosa, Seu de Pagis Antiquae Praesertim Germaniae Commentarius, Schlüsselseiten aus dem Exemplar der HAB Wolfenbüttel: Gm 86 (1)

Auch in: Paullini, Christian Franz: Gaeographia Curiosa, Seu de Pagis Antiquae Praesertim Germaniae Commentarius, Schlüsselseiten aus dem Exemplar der ULB Halle: Pon IIo 318 (2)

Schlüsselseiten aus Exemplar der SBB-PK berlin: Ee 700-1922, Signaturformel: A - B4, Erscheinungsjahr nach dem Sterbejahr angegeben, Text teilw. dt., teilw. lat.

Auch in: Christ. Francisci Paullini, Ferraria-Thuringi, Rerum Et Antiquitatum Germanicarum Syntagma, Schlüsselseiten aus dem Exemplar der ULB Halle: AB 67 13/e, 4 (2)

[Hrsg.: Christian Franz Paullini], Mutmaßl. Verf.: Christian Ludwig Kotzebue (s. DBA: Jöcher und Rotemund). - Hrsg. ermittelt in: Dünnhaupt, IV, S. 3095, Nr. 47, Schlüsselseiten aus dem Exemplar der BSB München: 4 H.mon. 126

Christiani Francisci Paullini, Schlüsselseiten aus dem Exemplar der ULB Halle: AB 154021 (2), Vorlageform des Erscheinungsvermerks: Francofurti ad Moenum, Impensis Friderici Knochii. Anno M DC XCIX.

Schlüsselseiten aus dem Exemplar der FB Gotha: Diss.phil 8° 130 (24), Vorlageform des Erscheinungsvermerks: Wittenbergae, Typis Christiani Schrödteri, Acad. Typogr. Anno MDCXCIII.

Schlüsselseiten aus dem Exemplar der ULB Halle: Pon IIa 1228 (1), Zeit-kürtzende Erbauliche Lust

Notis vero illustrata & edita a Christiano Francisco Paullini, Schlüsselseiten aus dem Exemplar der BSB München: 4 Diss. 124

Schlüsselseiten aus dem Exemplar der FB Gotha: Poes 8° 2727/1 (2), Zeit-Kürzende Erbauliche Lust

Innexis Aliquot Diplomatibus Et Literis Vere Authenticis Illustratus A Christiano Francisco Paullini, Schlüsselseiten aus dem Exemplar der SBB-PK: Fs 6145, Signaturformel: A-D4, Vorlageform des Erscheinungsvermerks: Jenæ. Typis Gollnerianis. Anno M.DC.LXXXVI.

Titelbl. in Rot- u. Schwarzdr, Vorlageform des Erscheinungsvermerks: Franckfurth und Leipzig, Bey Johann Christoph Stößeln, Buchhändlern in Effurth. Jm Jahr 1706.

Schlüsselseiten aus dem Exemplar der FB Gotha: Poes 8° 2727/1 (2), Zeit-Kürzende Erbauliche Lust

Männiglich zur beliebigen Ergetzung wohlmeinend mitgetheilt von Chr. Fr. Paullini, Vorlageform der Veröffentlichungsangabe: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt

Titelbl. in Rot- und Schwarzdr., Autopsie nach Ex. der ULB Sachsen-Anhalt, Philosophische Lust-Stunden, Vorlageform des Erscheinungsvermerks: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt, 1707. - Franckfurt und Leizig sind Messplätze

Titelbl. in Rot- und Schwarzdr., Autopsie nach Ex. der ULB Sachsen-Anhalt, Vorlageform des Erscheinungsvermerks: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt, 1706. - Franckfurt und Leipzig sind Messplätze

Nicht identisch mit Prod.-Nr. 1:069152U (unterschiedl. Umfang; dort: von Bl. ][7 verso mit einer weiterführenden Kustode "VII. Can-" auf Bl. ][][), Christiani Francisci Paullini Ilapa Curiosa

nunc ab Innumeris Sphalmatis vindicata, & Exterorum in gratiam, Latinitati donata, opera D. Christiani Francisci Paullini, Academici Curiosi, Schlüsselseiten aus dem Exemplar der ULB Halle: Ug 604 a, Paginierungsfehler: Sprung von S. 416 auf 447 (Bl. Ggg1r)

Titelbl. in Rot- u. Schwarzdr, Vorlageform des Erscheinungsvermerks: Franckfurth und Leipzig, Bey Johann Christoph Stößeln, Buchhändlern in Effurth. Jm Jahr 1706.

Männiglich zur beliebigen Ergetzung wohlmeinend mitgetheilt von Chr. Fr. Paullini, Vorlageform der Veröffentlichungsangabe: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt

Titelbl. in Rot- und Schwarzdr., Autopsie nach Ex. der ULB Sachsen-Anhalt, Vorlageform des Erscheinungsvermerks: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt, 1706. - Franckfurt und Leipzig sind Messplätze

Titelbl. in Rot- und Schwarzdr., Autopsie nach Ex. der ULB Sachsen-Anhalt, Philosophische Lust-Stunden, Vorlageform des Erscheinungsvermerks: Franckfurt und Leipzig, Bey Johann Christoff Stösseln, Buchhändlern in Erffurt, 1707. - Franckfurt und Leizig sind Messplätze

Schlüsselseiten aus dem Exemplar der FB Gotha: Poes 8° 2727/1 (2), Zeit-Kürzende Erbauliche Lust