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1. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Tzeis, S, Gerstenfeld, EP, Kalman, J, Saad, EB, Shamloo, AS, Andrade, JG, Barbhaiya, CR, Baykaner, T, Boveda, S, Calkins, H, Chan, N-Y, Chen, M, Chen, S-A, Dagres, N, Damiano, RJ, De Potter, T, Deisenhofer, I, Derval, N, Di Biase, L, Duytschaever, M, Dyrda, K, Hindricks, G, Hocini, M, Kim, Y-H, la Meir, M, Merino, JL, Michaud, GF, Natale, A, Nault, I, Nava, S, Nitta, T, O'Neill, M, Pak, H-N, Piccini, JP, Puererfellner, H, Reichlin, T, Saenz, LC, Sanders, P, Schilling, R, Schmidt, B, Supple, GE, Thomas, KL, Tondo, C, Verma, A, Wan, EY, Tzeis, S, Gerstenfeld, EP, Kalman, J, Saad, EB, Shamloo, AS, Andrade, JG, Barbhaiya, CR, Baykaner, T, Boveda, S, Calkins, H, Chan, N-Y, Chen, M, Chen, S-A, Dagres, N, Damiano, RJ, De Potter, T, Deisenhofer, I, Derval, N, Di Biase, L, Duytschaever, M, Dyrda, K, Hindricks, G, Hocini, M, Kim, Y-H, la Meir, M, Merino, JL, Michaud, GF, Natale, A, Nault, I, Nava, S, Nitta, T, O'Neill, M, Pak, H-N, Piccini, JP, Puererfellner, H, Reichlin, T, Saenz, LC, Sanders, P, Schilling, R, Schmidt, B, Supple, GE, Thomas, KL, Tondo, C, Verma, A, and Wan, EY

Abstract

In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007, the first joint expert consensus document was issued, guiding healthcare professionals involved in catheter or surgical AF ablation. Mounting research evidence and technological advances have resulted in a rapidly changing landscape in the field of catheter and surgical AF ablation, thus stressing the need for regularly updated versions of this partnership which were issued in 2012 and 2017. Seven years after the last consensus, an updated document was considered necessary to define a contemporary framework for selection and management of patients considered for or undergoing catheter or surgical AF ablation. This consensus is a joint effort from collaborating cardiac electrophysiology societies, namely the European Heart Rhythm Association, the Heart Rhythm Society, the Asia Pacific Heart Rhythm Society, and the Latin American Heart Rhythm Society .

Published
2024

2. From gene-discovery to gene-Tailored clinical management: 25 years of research in channelopathies and cardiomyopathies

Author

Crotti, L, Brugada, P, Calkins, H, Chevalier, P, Conte, G, Finocchiaro, G, Postema, P, Probst, V, Schwartz, P, Behr, E, Crotti L., Brugada P., Calkins H., Chevalier P., Conte G., Finocchiaro G., Postema P. G., Probst V., Schwartz P. J., Behr E. R., Crotti, L, Brugada, P, Calkins, H, Chevalier, P, Conte, G, Finocchiaro, G, Postema, P, Probst, V, Schwartz, P, Behr, E, Crotti L., Brugada P., Calkins H., Chevalier P., Conte G., Finocchiaro G., Postema P. G., Probst V., Schwartz P. J., and Behr E. R.

Abstract

In the early nineties, few years before the birth of Europace, the clinical and scientific world of familial arrhythmogenic conditions was revolutionized by the identification of the first disease-causing genes. The explosion of genetic studies over a 15-year period led to the discovery of major disease-causing genes in practically all channelopathies and cardiomyopathies, bringing insight into the pathophysiological mechanisms of these conditions. The birth of next generation sequencing allowed a further step forward and other significant genes, as CALM1-3 in channelopathies and FLN C and TTN in cardiomyopathies were identified. Genotype-phenotype studies allowed the implementation of the genetic results in diagnosis, risk stratification, and therapeutic management with a different level of evidence in different arrhythmogenic conditions. The influence of common genetic variants, i.e. SNPs, on disease manifestation was proved in mid-Twenties, and in the last 10 years with the advent of genome-wide association studies performed in familial arrhythmogenic diseases, the concept of polygenic risk score has been consolidated. Now, we are at the start of another amazing phase, i.e.The initiation of first gene therapy clinical trials.

Published
2023

3. Prognostic value of strain by feature-tracking cardiac magnetic resonance in arrhythmogenic right ventricular cardiomyopathy

Author

Onderzoek Precision medicine, Researchgr. Hart-brein as., Circulatory Health, Team Medisch, Brain, Arts Assistenten Cardiologie, Bourfiss, M., Prakken, N. H.J., James, C. A., Planken, R. N., Boekholdt, S. M., Ahmetagic, D., van den Berg, M. P., Tichnell, C., Van der Heijden, J. F., Loh, P., Murray, B., Tandri, H., Kamel, I., Calkins, H., Asselbergs, F. W., Zimmerman, S. L., Velthuis, B. K., Te Riele, A. S.J.M., Onderzoek Precision medicine, Researchgr. Hart-brein as., Circulatory Health, Team Medisch, Brain, Arts Assistenten Cardiologie, Bourfiss, M., Prakken, N. H.J., James, C. A., Planken, R. N., Boekholdt, S. M., Ahmetagic, D., van den Berg, M. P., Tichnell, C., Van der Heijden, J. F., Loh, P., Murray, B., Tandri, H., Kamel, I., Calkins, H., Asselbergs, F. W., Zimmerman, S. L., Velthuis, B. K., and Te Riele, A. S.J.M.

Published
2023

4. Cadherin 2-Related Arrhythmogenic Cardiomyopathy: Prevalence and Clinical Features

Author

Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., Crotti L., Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., and Crotti L.

Abstract

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of the right and left ventricle, often causing ventricular dysfunction and life-threatening arrhythmias. Variants in desmosomal genes account for up to 60% of cases. Our objective was to establish the prevalence and clinical features of ACM stemming from pathogenic variants in the nondesmosomal cadherin 2 (CDH2), a novel genetic substrate of ACM. Methods: A cohort of 500 unrelated patients with a definite diagnosis of ACM and no disease-causing variants in the main ACM genes was assembled. Genetic screening of CDH2 was performed through next-generation or Sanger sequencing. Whenever possible, cascade screening was initiated in the families of CDH2-positive probands, and clinical evaluation was performed. Results: Genetic screening of CDH2 led to the identification of 7 rare variants: 5, identified in 6 probands, were classified as pathogenic or likely pathogenic. The previously established p.D407N pathogenic variant was detected in 2 additional probands. Probands and family members with pathogenic/likely pathogenic variants in CDH2 were clinically evaluated, and along with previously published cases, altogether contributed to the identification of gene-specific features (13 cases from this cohort and 11 previously published, for a total of 9 probands and 15 family members). Ventricular arrhythmic events occurred in most CDH2-positive subjects (20/24, 83%), while the occurrence of heart failure was rare (2/24, 8.3%). Among probands, sustained ventricular tachycardia and sudden cardiac death occurred in 5/9 (56%). Conclusions: In this worldwide cohort of previously genotype-negative ACM patients, the prevalence of probands with CDH2 pathogenic/likely pathogenic variants was 1.2% (6/500). Our data show that this cohort of CDH2-ACM patients has a high incidence of ventricular arrhythmias, while evolution toward heart failure is rare.

Published
2021

5. Cadherin 2-Related Arrhythmogenic Cardiomyopathy: Prevalence and Clinical Features

Author

Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., Crotti L., Ghidoni, A, Elliott, P, Syrris, P, Calkins, H, James, C, Judge, D, Murray, B, Barc, J, Probst, V, Schott, J, Song, J, Hauer, R, Hoorntje, E, Van Tintelen, J, Schulze-Bahr, E, Hamilton, R, Mittal, K, Semsarian, C, Behr, E, Ackerman, M, Basso, C, Parati, G, Gentilini, D, Kotta, M, Mayosi, B, Schwartz, P, Crotti, L, Ghidoni A., Elliott P. M., Syrris P., Calkins H., James C. A., Judge D. P., Murray B., Barc J., Probst V., Schott J. J., Song J. -P., Hauer R. N. W., Hoorntje E. T., Van Tintelen J. P., Schulze-Bahr E., Hamilton R. M., Mittal K., Semsarian C., Behr E. R., Ackerman M. J., Basso C., Parati G., Gentilini D., Kotta M. -C., Mayosi B. M., Schwartz P. J., and Crotti L.

Abstract

Background: Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of the right and left ventricle, often causing ventricular dysfunction and life-threatening arrhythmias. Variants in desmosomal genes account for up to 60% of cases. Our objective was to establish the prevalence and clinical features of ACM stemming from pathogenic variants in the nondesmosomal cadherin 2 (CDH2), a novel genetic substrate of ACM. Methods: A cohort of 500 unrelated patients with a definite diagnosis of ACM and no disease-causing variants in the main ACM genes was assembled. Genetic screening of CDH2 was performed through next-generation or Sanger sequencing. Whenever possible, cascade screening was initiated in the families of CDH2-positive probands, and clinical evaluation was performed. Results: Genetic screening of CDH2 led to the identification of 7 rare variants: 5, identified in 6 probands, were classified as pathogenic or likely pathogenic. The previously established p.D407N pathogenic variant was detected in 2 additional probands. Probands and family members with pathogenic/likely pathogenic variants in CDH2 were clinically evaluated, and along with previously published cases, altogether contributed to the identification of gene-specific features (13 cases from this cohort and 11 previously published, for a total of 9 probands and 15 family members). Ventricular arrhythmic events occurred in most CDH2-positive subjects (20/24, 83%), while the occurrence of heart failure was rare (2/24, 8.3%). Among probands, sustained ventricular tachycardia and sudden cardiac death occurred in 5/9 (56%). Conclusions: In this worldwide cohort of previously genotype-negative ACM patients, the prevalence of probands with CDH2 pathogenic/likely pathogenic variants was 1.2% (6/500). Our data show that this cohort of CDH2-ACM patients has a high incidence of ventricular arrhythmias, while evolution toward heart failure is rare.

Published
2021

6. 2019 ESC Guidelines for themanagement of patients with supraventricular tachycardia

Author

Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, Gupta, D, Brugada J., Katritsis D. G., Arbelo E., Arribas F., Bax J. J., Blomstrom-Lundqvist C., Calkins H., Corrado D., Deftereos S. G., Diller G. -P., Gomez-Doblas J. J., Gorenek B., Grace A., Ho S. Y., Kaski J. -C., Kuck K. -H., Lambiase P. D., Sacher F., Sarquella-Brugada G., Suwalski P., Zaza A., De Potter T., Sticherling C., Aboyans V., Basso C., Bocchiardo M., Budts W., Delgado V., Dobrev D., Fitzsimons D., Gevaert S., Heidbuchel H., Hindricks G., Hlivak P., Kanagaratnam P., Katus H., Kautzner J., Kriebel T., Lancellotti P., Landmesser U., Leclercq C., Lewis B., Lopatin Y., Merkely B., Paul T., Pavlovic N., Petersen S., Petronio A. S., Potpara T., Roffi M., Scherr D., Shlyakhto E., Simpson I. A., Zeppenfeld K., Windecker S., Baigent C., Collet J. -P., Dean V., Gale C. P., Grobbee D. E., Halvorsen S., Iung B., Juni P., Lettino M., Mueller C., Richter D. J., Sousa-Uva M., Touyz R. M., Amara W., Grigoryan S., Podczeck-Schweighofer A., Chasnoits A., Vandekerckhove Y., Sokolovich S., Traykov V., Skoric B., Papasavvas E., Riahi S., Kampus P., Parikka H., Piot O., Etsadashvili K., Stellbrink C., Manolis A. S., Csanadi Z., Gudmundsson K., Erwin J., Barsheshet A., De Ponti R., Abdrakhmanov A., Jashari H., Lunegova O., Jubele K., Refaat M. M., Puodziukynas A., Groben L., Grosu A., Ibtissam F., Trines S. A., Poposka L., Haugaa K. H., Kowalski O., Cavaco D., Dobreanu D., Mikhaylov E. N., Zavatta M., Nebojsa M., Ferreira-Gonzalez I., Juhlin T., Reichlin T., Haouala H., Akgun T., Gupta D., Brugada, J, Katritsis, D, Arbelo, E, Arribas, F, Bax, J, Blomstrom-Lundqvist, C, Calkins, H, Corrado, D, Deftereos, S, Diller, G, Gomez-Doblas, J, Gorenek, B, Grace, A, Ho, S, Kaski, J, Kuck, K, Lambiase, P, Sacher, F, Sarquella-Brugada, G, Suwalski, P, Zaza, A, De Potter, T, Sticherling, C, Aboyans, V, Basso, C, Bocchiardo, M, Budts, W, Delgado, V, Dobrev, D, Fitzsimons, D, Gevaert, S, Heidbuchel, H, Hindricks, G, Hlivak, P, Kanagaratnam, P, Katus, H, Kautzner, J, Kriebel, T, Lancellotti, P, Landmesser, U, Leclercq, C, Lewis, B, Lopatin, Y, Merkely, B, Paul, T, Pavlovic, N, Petersen, S, Petronio, A, Potpara, T, Roffi, M, Scherr, D, Shlyakhto, E, Simpson, I, Zeppenfeld, K, Windecker, S, Baigent, C, Collet, J, Dean, V, Gale, C, Grobbee, D, Halvorsen, S, Iung, B, Juni, P, Lettino, M, Mueller, C, Richter, D, Sousa-Uva, M, Touyz, R, Amara, W, Grigoryan, S, Podczeck-Schweighofer, A, Chasnoits, A, Vandekerckhove, Y, Sokolovich, S, Traykov, V, Skoric, B, Papasavvas, E, Riahi, S, Kampus, P, Parikka, H, Piot, O, Etsadashvili, K, Stellbrink, C, Manolis, A, Csanadi, Z, Gudmundsson, K, Erwin, J, Barsheshet, A, De Ponti, R, Abdrakhmanov, A, Jashari, H, Lunegova, O, Jubele, K, Refaat, M, Puodziukynas, A, Groben, L, Grosu, A, Ibtissam, F, Trines, S, Poposka, L, Haugaa, K, Kowalski, O, Cavaco, D, Dobreanu, D, Mikhaylov, E, Zavatta, M, Nebojsa, M, Ferreira-Gonzalez, I, Juhlin, T, Reichlin, T, Haouala, H, Akgun, T, Gupta, D, Brugada J., Katritsis D. G., Arbelo E., Arribas F., Bax J. J., Blomstrom-Lundqvist C., Calkins H., Corrado D., Deftereos S. G., Diller G. -P., Gomez-Doblas J. J., Gorenek B., Grace A., Ho S. Y., Kaski J. -C., Kuck K. -H., Lambiase P. D., Sacher F., Sarquella-Brugada G., Suwalski P., Zaza A., De Potter T., Sticherling C., Aboyans V., Basso C., Bocchiardo M., Budts W., Delgado V., Dobrev D., Fitzsimons D., Gevaert S., Heidbuchel H., Hindricks G., Hlivak P., Kanagaratnam P., Katus H., Kautzner J., Kriebel T., Lancellotti P., Landmesser U., Leclercq C., Lewis B., Lopatin Y., Merkely B., Paul T., Pavlovic N., Petersen S., Petronio A. S., Potpara T., Roffi M., Scherr D., Shlyakhto E., Simpson I. A., Zeppenfeld K., Windecker S., Baigent C., Collet J. -P., Dean V., Gale C. P., Grobbee D. E., Halvorsen S., Iung B., Juni P., Lettino M., Mueller C., Richter D. J., Sousa-Uva M., Touyz R. M., Amara W., Grigoryan S., Podczeck-Schweighofer A., Chasnoits A., Vandekerckhove Y., Sokolovich S., Traykov V., Skoric B., Papasavvas E., Riahi S., Kampus P., Parikka H., Piot O., Etsadashvili K., Stellbrink C., Manolis A. S., Csanadi Z., Gudmundsson K., Erwin J., Barsheshet A., De Ponti R., Abdrakhmanov A., Jashari H., Lunegova O., Jubele K., Refaat M. M., Puodziukynas A., Groben L., Grosu A., Ibtissam F., Trines S. A., Poposka L., Haugaa K. H., Kowalski O., Cavaco D., Dobreanu D., Mikhaylov E. N., Zavatta M., Nebojsa M., Ferreira-Gonzalez I., Juhlin T., Reichlin T., Haouala H., Akgun T., and Gupta D.

Abstract

E' una "linea-guida" non esiste abstract.

Published
2020

7. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy: A Multinational Collaboration

Author

Cadrin-Tourigny, J. (Julia), Bosman, L.P. (Laurens P.), Wang, W. (Weijia), Tadros, R. (Rafik), Bhonsale, A. (Aditya), Bourfiss, M. (Mimount), Lie, ØH. (Øyvind H), Saguner, A.M. (Ardan M.), Svensson, A. (Anneli), Andorin, A. (Antoine), Tichnell, C. (Crystal), Murray, B. (Brittney), Zeppenfeld, K. (Katja), Berg, M.P. (Maarten) van den, Asselbergs, F.W. (Folkert W.), Wilde, A.A.M. (Arthur), Krahn, A.D. (Andrew D.), Talajic, M. (Mario), Rivard, L. (Lena), Chelko, S. (Stephen), Zimmerman, S.L. (Stefan L.), Kamel, M.S. (Mohamed), Crosson, J.E. (Jane E.), Judge, D.P. (Daniel), Yap, S.-C. (Sing-Chien), Van der Heijden, J.F. (Jeroen F.), Tandri, H. (Harikrishna), Jongbloed, J.D.H. (Jan), van Tintelen, J.P. (J Peter), Platonov, P.G. (Pyotr G.), Duru, F. (Firat), Haugaa, K.H. (Kristina H.), Khairy, P. (Paul), Hauer, R.N.W. (Richard), Calkins, H. (Hugh), Riele, A.S. (Anneline) te, James, C.A. (Cynthia A.), Cadrin-Tourigny, J. (Julia), Bosman, L.P. (Laurens P.), Wang, W. (Weijia), Tadros, R. (Rafik), Bhonsale, A. (Aditya), Bourfiss, M. (Mimount), Lie, ØH. (Øyvind H), Saguner, A.M. (Ardan M.), Svensson, A. (Anneli), Andorin, A. (Antoine), Tichnell, C. (Crystal), Murray, B. (Brittney), Zeppenfeld, K. (Katja), Berg, M.P. (Maarten) van den, Asselbergs, F.W. (Folkert W.), Wilde, A.A.M. (Arthur), Krahn, A.D. (Andrew D.), Talajic, M. (Mario), Rivard, L. (Lena), Chelko, S. (Stephen), Zimmerman, S.L. (Stefan L.), Kamel, M.S. (Mohamed), Crosson, J.E. (Jane E.), Judge, D.P. (Daniel), Yap, S.-C. (Sing-Chien), Van der Heijden, J.F. (Jeroen F.), Tandri, H. (Harikrishna), Jongbloed, J.D.H. (Jan), van Tintelen, J.P. (J Peter), Platonov, P.G. (Pyotr G.), Duru, F. (Firat), Haugaa, K.H. (Kristina H.), Khairy, P. (Paul), Hauer, R.N.W. (Richard), Calkins, H. (Hugh), Riele, A.S. (Anneline) te, and James, C.A. (Cynthia A.)

Abstract

BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. METHODS: We assembled a retrospective cohort of definite ARVC cases from 15 centers in North America and Europe. Association of 8 prespecified clinical predictors with LTVA (SCD, aborted SCD, sustained, or implantable cardioverter-defibrillator treated ventricular tachycardia >250 beats per minute) in follow-up was assessed by Cox regression with backward selection. Candidate variables included age, sex, prior sustained VA (≥30s, hemodynamically unstable, or implantable cardioverter-defibrillator treated ventricular tachycardia; or aborted SCD), syncope, 24-hour premature ventricular complexes count, the number of anterior and inferior leads with T-wave inversion, left and right ventricular ejection fraction. The resulting model was internally validated using bootstrapping. RESULTS: A total of 864 patients with definite ARVC (40±16 years; 53% male) were included. Over 5.75 years (interquartile range, 2.77-10.58) of follow-up, 93 (10.8%) patients experienced LTVA including 15 with SCD/aborted SCD (1.7%). Of the 8 prespecified clinical predictors, only 4 (younger age, male sex, premature ventricular complex count, and number of leads with T-wave inversion) were associated with LTVA. Notably, prior sustained VA did not predict subsequent LTVA (P=0.850). A model including only these 4 predictors had an optimism-corrected C-index of 0.74 (95% CI, 0.69-0.80) and calibration slope of 0.95 (95% CI, 0.94-0.98) indicating minimal over-optimism. CONCLUSION

Published
2021
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8. Sudden Cardiac Death Prediction in Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Cadrin-Tourigny, J, Bosman, LP, Wang, W, Tadros, R, Bhonsale, A, Bourfiss, M, Lie, Ø, Saguner, AM, Svensson, A, Andorin, A, Tichnell, C, Murray, B, Zeppenfeld, K, Van Den Berg, MP, Asselbergs, FW, Wilde, AA, Krahn, AD, Talajic, M, Rivard, L, Chelko, S, Zimmerman, SL, Kamel, IR, Crosson, JE, Judge, DP, Yap, Sing, van der Heijden, JF, Tandri, H, Jongbloed, JD, Tintelen, JP, Platonov, PG, Duru, F, Haugaa, KH, Khairy, P, Hauer, RN, Calkins, H, te Riele, Asjm, James, CA, Cadrin-Tourigny, J, Bosman, LP, Wang, W, Tadros, R, Bhonsale, A, Bourfiss, M, Lie, Ø, Saguner, AM, Svensson, A, Andorin, A, Tichnell, C, Murray, B, Zeppenfeld, K, Van Den Berg, MP, Asselbergs, FW, Wilde, AA, Krahn, AD, Talajic, M, Rivard, L, Chelko, S, Zimmerman, SL, Kamel, IR, Crosson, JE, Judge, DP, Yap, Sing, van der Heijden, JF, Tandri, H, Jongbloed, JD, Tintelen, JP, Platonov, PG, Duru, F, Haugaa, KH, Khairy, P, Hauer, RN, Calkins, H, te Riele, Asjm, and James, CA

Abstract

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients with ARVC. However, since this outcome may overestimate the risk for SCD, we aimed to specifically predict life-threatening VA (LTVA) as a closer surrogate for SCD. Methods: We assembled a retrospective cohort of definite ARVC cases from 15 centers in North America and Europe. Association of 8 prespecified clinical predictors with LTVA (SCD, aborted SCD, sustained, or implantable cardioverter-defibrillator treated ventricular tachycardia >250 beats per minute) in follow-up was assessed by Cox regression with backward selection. Candidate variables included age, sex, prior sustained VA (≥30s, hemodynamically unstable, or implantable cardioverter-defibrillator treated ventricular tachycardia; or aborted SCD), syncope, 24-hour premature ventricular complexes count, the number of anterior and inferior leads with T-wave inversion, left and right ventricular ejection fraction. The resulting model was internally validated using bootstrapping. Results: A total of 864 patients with definite ARVC (40±16 years; 53% male) were included. Over 5.75 years (interquartile range, 2.77-10.58) of follow-up, 93 (10.8%) patients experienced LTVA including 15 with SCD/aborted SCD (1.7%). Of the 8 prespecified clinical predictors, only 4 (younger age, male sex, premature ventricular complex count, and number of leads with T-wave inversion) were associated with LTVA. Notably, prior sustained VA did not predict subsequent LTVA (P=0.850). A model including only these 4 predictors had an optimism-corrected C-index of 0.74 (95% CI, 0.69-0.80) and calibration slope of 0.95 (95% CI, 0.94-0.98) indicating minimal over-optimism. Conclusions: LTVA events in patients with ARVC can be predicted by a novel simple prediction model using only 4 clinical predictors. Prior sustaine

Published
2021

9. Uninterrupted anticoagulation with non-vitamin K antagonist oral anticoagulants in atrial fibrillation catheter ablation: Lessons learned from randomized trials

Author

Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., Calkins, H., Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., and Calkins, H.

Abstract

Contains fulltext : 202709.pdf (publisher's version ) (Open Access), Catheter ablation has been established as a rhythm control strategy in selected patients with atrial fibrillation (AF) who have failed or wish to avoid anti-arrhythmic drugs. Uninterrupted oral anticoagulation with vitamin K antagonists (VKAs) peri-ablation is associated with a lower risk of thromboembolic and bleeding complications as compared to interrupted oral anticoagulation and bridging heparin. However, a substantial portion of patients with AF are treated with non-vitamin K antagonist oral anticoagulants (NOACs). Herein, we perform an in-depth review and comparison of three recent randomized trials of uninterrupted oral anticoagulation with NOACs vs VKAs in patients undergoing AF catheter ablation. Furthermore, we report pooled results of these randomized trials. The pooled incidence of major bleeding was significantly lower with NOACs as compared to VKAs (2% vs 4.9%, respectively; odds ratio [OR] 0.40; 95% confidence intervals [CI] 0.16-0.99). Similarly, cardiac tamponade was also reduced in the NOAC group (0.4% vs 1.5%; OR 0.27; 95% CI 0.07-0.97). Thromboembolic complications were not significantly different between groups. Overall, these findings support the 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement's class I recommendation for uninterrupted NOAC use in patients undergoing AF catheter ablation.

Published
2019

10. A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Author

Cadrin-Tourigny, J. (Julia), Bosman, L.P. (Laurens P.), Nozza, A. (Anna), Wang, W. (Weijia), Tadros, R. (Rafik), Bhonsale, A. (Aditya), Bourfiss, M. (Mimount), Fortier, A. (Annik), Lie, ØH. (Øyvind H), Saguner, A.M. (Ardan M.), Svensson, A. (Anneli), Andorin, A. (Antoine), Tichnell, C. (Crystal), Murray, B. (Brittney), Zeppenfeld, K. (Katja), Berg, M.P. (Maarten) van den, Asselbergs, F.W. (Folkert), Wilde, A.A.M. (Arthur), Krahn, A.D. (Andrew D.), Talajic, M. (Mario), Rivard, L. (Lena), Chelko, S. (Stephen), Zimmerman, S.L. (Stefan), Kamel, M.S. (Mohamed), Crosson, J.E. (Jane E.), Judge, D.P. (Daniel), Yap, S.-C. (Sing-Chien), Heijden, J.F. (Jeroen) van der, Tandri, H. (Harikrishna), Jongbloed, J.D.H. (Jan), Guertin, M.-C. (Marie-Claude), Tintelen, J.P. (Peter) van, Platonov, P.G. (Pyotr G.), Duru, F. (Firat), Haugaa, K.H. (Kristina H.), Khairy, P. (Paul), Hauer, R.N.W. (Richard), Calkins, H. (Hugh), Riele, A.S. (Anneline) te, James, C.A. (Cynthia), Cadrin-Tourigny, J. (Julia), Bosman, L.P. (Laurens P.), Nozza, A. (Anna), Wang, W. (Weijia), Tadros, R. (Rafik), Bhonsale, A. (Aditya), Bourfiss, M. (Mimount), Fortier, A. (Annik), Lie, ØH. (Øyvind H), Saguner, A.M. (Ardan M.), Svensson, A. (Anneli), Andorin, A. (Antoine), Tichnell, C. (Crystal), Murray, B. (Brittney), Zeppenfeld, K. (Katja), Berg, M.P. (Maarten) van den, Asselbergs, F.W. (Folkert), Wilde, A.A.M. (Arthur), Krahn, A.D. (Andrew D.), Talajic, M. (Mario), Rivard, L. (Lena), Chelko, S. (Stephen), Zimmerman, S.L. (Stefan), Kamel, M.S. (Mohamed), Crosson, J.E. (Jane E.), Judge, D.P. (Daniel), Yap, S.-C. (Sing-Chien), Heijden, J.F. (Jeroen) van der, Tandri, H. (Harikrishna), Jongbloed, J.D.H. (Jan), Guertin, M.-C. (Marie-Claude), Tintelen, J.P. (Peter) van, Platonov, P.G. (Pyotr G.), Duru, F. (Firat), Haugaa, K.H. (Kristina H.), Khairy, P. (Paul), Hauer, R.N.W. (Richard), Calkins, H. (Hugh), Riele, A.S. (Anneline) te, and James, C.A. (Cynthia)

Abstract

AIMS: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. METHODS AND RESULTS: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interquartile range 2.44-9.33) years of follow-up, 146 (27.7%) experienced sustained VA, defined as SCD, aborted SCD, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator (ICD) therapy. A prediction model estimating annual VA risk was developed using Cox regression with internal validation. Eight potential predictors were pre-specified: age, sex, cardiac syncope in the prior 6 months, non-sustained ventricular tachycardia, number of premature ventricular complexes in 24 h, number of leads with T-wave inversion, and right and left ventricular ejection fractions (LVEFs). All except LVEF were retained in the final model. The model accurately distinguished patients with and without events, with an optimism-corrected C-index of 0.77 [95% confidence interval (CI) 0.73-0.81] and minimal over-optimism [calibration slope of 0.93 (95% CI 0.92-0.95)]. By decision curve analysis, the clinical benefit of the model was superior to a current consensus-based ICD placement algorithm with a 20.6% reduction of ICD placements with the same proportion of protected patients (P < 0.001). CONCLUSION: Using the largest cohort of patients with ARVC and no prior VA, a prediction model using readily available clinical parameters was devised to estimate VA risk and guide decisions regarding primary prevention ICDs (www.arvcrisk.com).

Published
2019
Full Text
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11. Uninterrupted anticoagulation with non-vitamin K antagonist oral anticoagulants in atrial fibrillation catheter ablation: Lessons learned from randomized trials

Author

Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., Calkins, H., Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., and Calkins, H.

Abstract

Contains fulltext : 202709.pdf (publisher's version ) (Open Access), Catheter ablation has been established as a rhythm control strategy in selected patients with atrial fibrillation (AF) who have failed or wish to avoid anti-arrhythmic drugs. Uninterrupted oral anticoagulation with vitamin K antagonists (VKAs) peri-ablation is associated with a lower risk of thromboembolic and bleeding complications as compared to interrupted oral anticoagulation and bridging heparin. However, a substantial portion of patients with AF are treated with non-vitamin K antagonist oral anticoagulants (NOACs). Herein, we perform an in-depth review and comparison of three recent randomized trials of uninterrupted oral anticoagulation with NOACs vs VKAs in patients undergoing AF catheter ablation. Furthermore, we report pooled results of these randomized trials. The pooled incidence of major bleeding was significantly lower with NOACs as compared to VKAs (2% vs 4.9%, respectively; odds ratio [OR] 0.40; 95% confidence intervals [CI] 0.16-0.99). Similarly, cardiac tamponade was also reduced in the NOAC group (0.4% vs 1.5%; OR 0.27; 95% CI 0.07-0.97). Thromboembolic complications were not significantly different between groups. Overall, these findings support the 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement's class I recommendation for uninterrupted NOAC use in patients undergoing AF catheter ablation.

Published
2019

12. Uninterrupted anticoagulation with non-vitamin K antagonist oral anticoagulants in atrial fibrillation catheter ablation: Lessons learned from randomized trials

Author

Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., Calkins, H., Cardoso, R., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Nordaby, M., Brouwer, M.A., and Calkins, H.

Abstract

Contains fulltext : 202709.pdf (publisher's version ) (Open Access), Catheter ablation has been established as a rhythm control strategy in selected patients with atrial fibrillation (AF) who have failed or wish to avoid anti-arrhythmic drugs. Uninterrupted oral anticoagulation with vitamin K antagonists (VKAs) peri-ablation is associated with a lower risk of thromboembolic and bleeding complications as compared to interrupted oral anticoagulation and bridging heparin. However, a substantial portion of patients with AF are treated with non-vitamin K antagonist oral anticoagulants (NOACs). Herein, we perform an in-depth review and comparison of three recent randomized trials of uninterrupted oral anticoagulation with NOACs vs VKAs in patients undergoing AF catheter ablation. Furthermore, we report pooled results of these randomized trials. The pooled incidence of major bleeding was significantly lower with NOACs as compared to VKAs (2% vs 4.9%, respectively; odds ratio [OR] 0.40; 95% confidence intervals [CI] 0.16-0.99). Similarly, cardiac tamponade was also reduced in the NOAC group (0.4% vs 1.5%; OR 0.27; 95% CI 0.07-0.97). Thromboembolic complications were not significantly different between groups. Overall, these findings support the 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement's class I recommendation for uninterrupted NOAC use in patients undergoing AF catheter ablation.

Published
2019

13. A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy

Author

Cadrin-Tourigny, J, Bosman, LP, Nozza, A, Wang, WJ, Tadros, R, Bhonsale, A, Bourfiss, M, Fortier, A, Lie, OH, Saguner, AM, Svensson, A, Andorin, A, Tichnell, C, Murray, B, Zeppenfeld, K, Lambregtse-van den Berg, MP, Asselbergs, FW, Wilde, AA, Krahn, AD, Talajic, M, Rivard, L, Chelko, S, Zimmerman, SL, Kamel, IR, Crosson, JE, Judge, DP, Yap, Sing, van der Heijden, JF, Tandri, H, Jongbloed, JD, Guertin, MC, Tintelen, JP, Platonov, PG, Duru, F, Haugaa, KH, Khairy, P, Hauer, RN, Calkins, H, te Riele, A, James, CA, Cadrin-Tourigny, J, Bosman, LP, Nozza, A, Wang, WJ, Tadros, R, Bhonsale, A, Bourfiss, M, Fortier, A, Lie, OH, Saguner, AM, Svensson, A, Andorin, A, Tichnell, C, Murray, B, Zeppenfeld, K, Lambregtse-van den Berg, MP, Asselbergs, FW, Wilde, AA, Krahn, AD, Talajic, M, Rivard, L, Chelko, S, Zimmerman, SL, Kamel, IR, Crosson, JE, Judge, DP, Yap, Sing, van der Heijden, JF, Tandri, H, Jongbloed, JD, Guertin, MC, Tintelen, JP, Platonov, PG, Duru, F, Haugaa, KH, Khairy, P, Hauer, RN, Calkins, H, te Riele, A, and James, CA

Published
2019

14. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2018
Full Text
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15. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina K.), Cosedis Nielsen, J. (Jens), Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), D'Avila, A. (Andr'E), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), MacLe, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R.), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2018
Full Text
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16. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2018

17. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2018

18. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, and Yamane, T

Published
2018

19. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, and Yamane, T

Published
2018

20. Heart Failure is Common and Under-Recognized in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author

Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., Tedford, R.J., Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., and Tedford, R.J.

Published
2017

21. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2017
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22. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Davies, D.W. (D. Wyn), Day, J.D. (John D.), d'Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2017
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23. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

Author

Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Wyn Davies, D. (D.), Day, J.D. (John D.), d’Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), Yamane, T. (Teiichi), Calkins, H. (Hugh), Hindricks, G. (Gerhard), Cappato, R. (Riccardo), Kim, Y.-H. (Young-Hoon), Saad, E.B. (Eduardo B.), Aguinaga, L. (Luis), Akar, J.G. (Joseph G.), Badhwar, V. (Vinay), Brugada, J. (Josep), Camm, J. (John), Chen, P.-S. (Peng-Sheng), Chen, S.-A. (Shih-Ann), Chung, M.K. (Mina), Nielsen, J.C., Curtis, A.B. (Anne B.), Wyn Davies, D. (D.), Day, J.D. (John D.), d’Avila, A. (André), Groot, N.M.S. (Natasja) de, Di Biase, L. (Luigi), Duytschaever, M. (Mattias), Edgerton, J.R. (James R.), Ellenbogen, K.A. (Kenneth), Ellinor, P.T. (Patrick), Ernst, S. (Sabine), Fenelon, G. (Guilherme), Gerstenfeld, E.P. (Edward P.), Haines, D.E. (David E.), Haissaguerre, M. (Michel), Helm, R.H. (Robert H.), Hylek, E. (Elaine), Jackman, W.M. (Warren M.), Jalife, J. (Jose), Kalman, J.M. (Jonathan M.), Kautzner, J. (Josef), Kottkamp, H. (Hans), Kuck, K.H. (Karl Heinz), Kumagai, K. (Koichiro), Lee, R. (Richard), Lewalter, T. (Thorsten), Lindsay, B.D. (Bruce D.), Macle, L. (Laurent), Mansour, M. (Moussa), Marchlinski, F.E. (Francis E.), Michaud, G.F. (Gregory F.), Nakagawa, H. (Hiroshi), Natale, A. (Andrea), Nattel, S. (Stanley), Okumura, K. (Ken), Packer, D.L. (Douglas L.), Pokushalov, E. (Evgeny), Reynolds, M.R. (Matthew R), Sanders, P. (Prashanthan), Scanavacca, M. (Mauricio), Schilling, R. (Richard), Tondo, C. (Claudio), Tsao, H.-M. (Hsuan-Ming), Verma, A. (Atul), Wilber, D.J. (David J.), and Yamane, T. (Teiichi)

Published
2017
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24. Heart Failure is Common and Under-Recognized in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author

Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., Tedford, R.J., Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., and Tedford, R.J.

Published
2017

25. Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation

Author

Calkins, H., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Serota, H., Nordaby, M., Guiver, K., Biss, B., Brouwer, M.A., Grimaldi, M., Calkins, H., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Serota, H., Nordaby, M., Guiver, K., Biss, B., Brouwer, M.A., and Grimaldi, M.

Abstract

Contains fulltext : 182933.pdf (publisher's version ) (Open Access), BACKGROUND: Catheter ablation of atrial fibrillation is typically performed with uninterrupted anticoagulation with warfarin or interrupted non-vitamin K antagonist oral anticoagulant therapy. Uninterrupted anticoagulation with a non-vitamin K antagonist oral anticoagulant, such as dabigatran, may be safer; however, controlled data are lacking. We investigated the safety of uninterrupted dabigatran versus warfarin in patients undergoing ablation of atrial fibrillation. METHODS: In this randomized, open-label, multicenter, controlled trial with blinded adjudicated end-point assessments, we randomly assigned patients scheduled for catheter ablation of paroxysmal or persistent atrial fibrillation to receive either dabigatran (150 mg twice daily) or warfarin (target international normalized ratio, 2.0 to 3.0). Ablation was performed after 4 to 8 weeks of uninterrupted anticoagulation, which was continued during and for 8 weeks after ablation. The primary end point was the incidence of major bleeding events during and up to 8 weeks after ablation; secondary end points included thromboembolic and other bleeding events. RESULTS: The trial enrolled 704 patients across 104 sites; 635 patients underwent ablation. Baseline characteristics were balanced between treatment groups. The incidence of major bleeding events during and up to 8 weeks after ablation was lower with dabigatran than with warfarin (5 patients [1.6%] vs. 22 patients [6.9%]; absolute risk difference, -5.3 percentage points; 95% confidence interval, -8.4 to -2.2; P<0.001). Dabigatran was associated with fewer periprocedural pericardial tamponades and groin hematomas than warfarin. The two treatment groups had a similar incidence of minor bleeding events. One thromboembolic event occurred in the warfarin group. CONCLUSIONS: In patients undergoing ablation for atrial fibrillation, anticoagulation with uninterrupted dabigatran was associated with fewer bleeding complications than uninterrupted warfarin. (Funded by

Published
2017

26. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, W, Day, JD, d'Avila, A, De Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, W, Day, JD, d'Avila, A, De Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

27. 2017HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

28. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, Y-H, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, P-S, Chen, S-A, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, NMSN, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, H-M, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

29. Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation

Author

Calkins, H., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Serota, H., Nordaby, M., Guiver, K., Biss, B., Brouwer, M.A., Grimaldi, M., Calkins, H., Willems, S., Gerstenfeld, E.P., Verma, A., Schilling, R., Hohnloser, S.H., Okumura, K., Serota, H., Nordaby, M., Guiver, K., Biss, B., Brouwer, M.A., and Grimaldi, M.

Abstract

Contains fulltext : 182933.pdf (publisher's version ) (Open Access), BACKGROUND: Catheter ablation of atrial fibrillation is typically performed with uninterrupted anticoagulation with warfarin or interrupted non-vitamin K antagonist oral anticoagulant therapy. Uninterrupted anticoagulation with a non-vitamin K antagonist oral anticoagulant, such as dabigatran, may be safer; however, controlled data are lacking. We investigated the safety of uninterrupted dabigatran versus warfarin in patients undergoing ablation of atrial fibrillation. METHODS: In this randomized, open-label, multicenter, controlled trial with blinded adjudicated end-point assessments, we randomly assigned patients scheduled for catheter ablation of paroxysmal or persistent atrial fibrillation to receive either dabigatran (150 mg twice daily) or warfarin (target international normalized ratio, 2.0 to 3.0). Ablation was performed after 4 to 8 weeks of uninterrupted anticoagulation, which was continued during and for 8 weeks after ablation. The primary end point was the incidence of major bleeding events during and up to 8 weeks after ablation; secondary end points included thromboembolic and other bleeding events. RESULTS: The trial enrolled 704 patients across 104 sites; 635 patients underwent ablation. Baseline characteristics were balanced between treatment groups. The incidence of major bleeding events during and up to 8 weeks after ablation was lower with dabigatran than with warfarin (5 patients [1.6%] vs. 22 patients [6.9%]; absolute risk difference, -5.3 percentage points; 95% confidence interval, -8.4 to -2.2; P<0.001). Dabigatran was associated with fewer periprocedural pericardial tamponades and groin hematomas than warfarin. The two treatment groups had a similar incidence of minor bleeding events. One thromboembolic event occurred in the warfarin group. CONCLUSIONS: In patients undergoing ablation for atrial fibrillation, anticoagulation with uninterrupted dabigatran was associated with fewer bleeding complications than uninterrupted warfarin. (Funded by

Published
2017

30. Heart Failure is Common and Under-Recognized in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author

Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., Tedford, R.J., Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., and Tedford, R.J.

Published
2017

33. Heart Failure is Common and Under-Recognized in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author

Team Onderzoek, Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., Tedford, R.J., Team Onderzoek, Gilotra, N, Bhonsale, Aditya, James, C.A., te Riele, ASJM, Murray, Brittney, Tichnell, C., Sawant, Abhishek C., Ong, C.S., Judge, D.P., Russell, S.D., Calkins, H., and Tedford, R.J.

Published
2017

34. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

35. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation: Executive summary

Author

Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, Yamane, T, Calkins, H, Hindricks, G, Cappato, R, Kim, YH, Saad, EB, Aguinaga, L, Akar, JG, Badhwar, V, Brugada, J, Camm, J, Chen, PS, Chen, SA, Chung, MK, Nielsen, JC, Curtis, AB, Davies, DW, Day, JD, d'Avila, A, de Groot, Natasja, Di Biase, L, Duytschaever, M, Edgerton, JR, Ellenbogen, KA, Ellinor, PT, Ernst, S, Fenelon, G, Gerstenfeld, EP, Haines, DE, Haissaguerre, M, Helm, RH, Hylek, E, Jackman, WM, Jalife, J, Kalman, JM, Kautzner, J, Kottkamp, H, Kuck, KH, Kumagai, K, Lee, R, Lewalter, T, Lindsay, BD, Macle, L, Mansour, M, Marchlinski, FE, Michaud, GF, Nakagawa, H, Natale, A, Nattel, S, Okumura, K, Packer, D, Pokushalov, E, Reynolds, MR, Sanders, P, Scanavacca, M, Schilling, R, Tondo, C, Tsao, HM, Verma, A, Wilber, DJ, and Yamane, T

Published
2017

37. Right ventricular strain by MR quantitatively identifies regional dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy

Author

Vigneault, D.M. (Davis M.), Riele, A.S. (Anneline) te, James, C.A. (Cynthia), Zimmerman, S.L. (Stefan), Selwaness, M. (Mariana), Murray, B. (Brittney), Tichnell, C. (Crystal), Tee, M. (Michael), Noble, J.A. (J. Alison), Calkins, H. (Hugh), Tandri, H. (Harikrishna), Bluemke, D.A. (David), Vigneault, D.M. (Davis M.), Riele, A.S. (Anneline) te, James, C.A. (Cynthia), Zimmerman, S.L. (Stefan), Selwaness, M. (Mariana), Murray, B. (Brittney), Tichnell, C. (Crystal), Tee, M. (Michael), Noble, J.A. (J. Alison), Calkins, H. (Hugh), Tandri, H. (Harikrishna), and Bluemke, D.A. (David)

Abstract

Background Analysis of regional wall motion of the right ventricle (RV) is primarily qualitative with large interobserver variation in clinical practice. Thus, the purpose of this study was to use feature tracking to analyze regional wall motion abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods We enrolled 110 subjects (39 overt ARVC [mutation+/phenotype+] (35.5%), 40 preclinical ARVC [mutation+/phenotype-] (36.3%), and 31 control subjects (28.2%)). Cine steady state free precession cardiac MR was performed with temporal resolution ≤40 ms in the horizontal long axis (HLA), axial, and short axis directions. Regional strain was analyzed using feature tracking software and reproducibility was assessed by means of intraclass correlation coefficient. Dunnett's test was used in univariate analysis for comparisons to control subjects; cumulative odds logistic regression was used for minimally and fully adjusted multivariate models. Results Strain was significantly impaired in overt ARVC compared with control subjects both globally (P

Published
2016
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43. Epizootic hemorrhagic deer disease study, South Dakota

Author

Calkins, H. E. and Calkins, H. E.

Subjects
Deer Diseases South Dakota., Communicable diseases in animals South Dakota., Cerfs Maladies Dakota du Sud., Animaux Maladies infectieuses Dakota du Sud., Communicable diseases in animals., Deer Diseases., South Dakota.
Published
1964

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