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Songting Li,1,2 Xiaolan Cai,3 Keyao Yu,1,2 Weihua Pan1,2 1Department of Dermatology, Second Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai, People’s Republic of China; 3Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, People’s Republic of ChinaCorrespondence: Weihua Pan, Department of Dermatology, Second Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China, Tel +86-2188485495, Email panweihua9@sina.comBackground: Cutaneous metastasis is rare in clinical practice, especially that from primary hepatocellular carcinoma (HCC), which is even rarer.Case Presentation: This report describes a male patient with HCC with cutaneous metastases to the nasal tip. The patient developed a raised nodule at the nasal tip 5 years after surgery for HCC, with surface ulceration and crusting and no obvious symptoms. Abdominal computed tomography (CT) showed an obvious mass in the liver. The skin lesions on the nasal tip were confirmed to be cutaneous metastasis of HCC by histopathological and immunohistochemical examinations.Conclusion: The incidence of cutaneous metastasis of HCC is extremely low, and nasal tip cutaneous metastasis of HCC has no specific clinical manifestations; therefore, it needs to be distinguished from rosacea rhinophyma, fungal and atypical mycobacterial infections, tumours of vascular origin, and tumours of skin appendages that occur in the nasal tip and is prone to misdiagnosis and missed diagnosis, thus requiring clinical dermatologists and otolaryngologists to be aware of such metastasis.Keywords: primary, hepatocellular carcinoma, metastatic cancer, skin, nasal tip

Weiyuan Ma,1 Ruyu Zhan,2 Changlin Sui,3 Fushan Zhou,2 Haidong Liu,4 Xiuwen Zhang,5 Zhenqiang Ruan,6 Yukun Wang,7 Xiaolan Cai8 1Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Scientific Research Center, Anxi County Hospital, Quanzhou, Fujian, People’s Republic of China; 3Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, Shandong, People’s Republic of China; 4Department of Dermatology, Liaocheng People’s Hospital, Liaocheng, Shandong, People’s Republic of China; 5Department of Dermatology, Weihai Municipal Hospital, Weihai, Shandong, People’s Republic of China; 6Department of Dermatology, Jinan Dermatosis Prevention and Control Hospital, Jinan, Shandong, People’s Republic of China; 7Department of Dermatology, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of China; 8Department of Otolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Weiyuan Ma, Department of Dermatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, People’s Republic of China, Email fymaweiyuan@wfmc.edu.cnPurpose: The clinical and pathological data of patients with rhinofacial ulcers were retrospectively reviewed and analyzed to lay the foundation for standardized clinical treatment.Patients and Methods: We retrospectively analyzed the clinical data, etiology, pathological features, treatment methods, and prognosis of 243 patients with rhinofacial ulcers treated in the Departments of Otorhinolaryngology and Dermatology at six hospitals in Shandong Province, China from July 2014 to October 2021. The clinical characteristics and treatment methods of the rhinofacial ulcers were summarized to provide a basis for standardizing patients’ diagnosis and treatment.Results: The male-to-female ratio of the 243 patients was 2.04:1, and their ages ranged from 25 to 91 years. The most common sit