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1. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis:A MASK-air study

Author: Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, Ulrik, Charlotte Suppli, Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, and Ulrik, Charlotte Suppli
Abstract: Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control., Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Published: 2024

2. Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis:A MASK-air study

Author: Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, Ulrik, Charlotte Suppli, Sousa-Pinto, Bernardo, Louis, Gilles, Vieira, Rafael J., Czarlewski, Wienczyslawa, Anto, Josep M., Amaral, Rita, Sá-Sousa, Ana, Brussino, Luisa, Canonica, G. Walter, Loureiro, Claudia Chaves, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée E., Pham-Thi, Nhân, Puggioni, Francesca, Regateiro, Frederico S., Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Agache, Ioana, Bedbrook, Anna, Benfante, Alida, Bergmann, Karl C., Bosnic-Anticevich, Sinthia, Bonini, Matteo, Boulet, Louis Philippe, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Costa, Elisio M., Del Giacco, Stefano, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Niedoszytko, Marek, Papadopoulos, Nikolaos G., Papi, Alberto, Pfaar, Oliver, Rivero-Yeverino, Daniela, and Ulrik, Charlotte Suppli
Abstract: Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control., Rationale: It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives: To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods: In this cross-sectional study, we assessed real-world data using the MASK-air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e-DASTHMA score). Results were validated in a sample of patients with a physician-established diagnosis of asthma. Measurement and Main Results: We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e-DASTHMA. Consistent results were observed when assessing patients with a physician-made diagnosis of asthma. Conclusions: Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Published: 2024

3. Patient-centered digital biomarkers for allergic respiratory diseases and asthma:The ARIA-EAACI approach – ARIA-EAACI Task Force Report

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed., Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023

4. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023
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5. Real-World Experience on the Use of Mepolizumab from the Severe Asthma Registry of the German Asthma Net (MepoGAN-Study)

Author: Korn,Stephanie, Milger,Katrin, Skowasch,Dirk, Schulz,Christian, Mohrlang,Cordula, Wernitz,Martin, Paulsson,Thomas, Hennig,Michael, Buhl,Roland, Korn,Stephanie, Milger,Katrin, Skowasch,Dirk, Schulz,Christian, Mohrlang,Cordula, Wernitz,Martin, Paulsson,Thomas, Hennig,Michael, and Buhl,Roland
Abstract: Stephanie Korn,1 Katrin Milger,2 Dirk Skowasch,3 Christian Schulz,4 Cordula Mohrlang,5 Martin Wernitz,5 Thomas Paulsson,6 Michael Hennig,5 Roland Buhl7 1IKF Pneumologie Mainz, Mainz and Thoraxklinik Heidelberg, Heidelberg, Germany; 2Department of Medicine V, University Hospital, LMU Munich, Munich and Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany; 3University Hospital Bonn, Pneumology, Bonn, Germany; 4University Hospital Regensburg, Internal Medicine II, Pneumology, Regensburg, Germany; 5GlaxoSmithKline GmbH & Co. KG, Munich, Germany; 6GlaxoSmithKline Plc, Brentford, UK; 7Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, GermanyCorrespondence: Cordula Mohrlang, GlaxoSmithKline GmbH & Co. KG, Prinzregentenplatz 9, MÃ¼nchen, D-81675, Germany, Tel + 49 163 360 5201, Email cordula.c.mohrlang@gsk.comPurpose: The German Asthma Net (GAN) operates a Severe Asthma Registry that provides an overview of the clinical presentation and management of patients with severe asthma. Based upon data from the GAN registry, the MepoGAN study aimed to describe clinical profiles and treatment outcomes of patients who were treated with the anti-IL-5 monoclonal antibody mepolizumab (NucalaTM) in routine practice in Germany.Patients and Methods: The MepoGAN study is a descriptive retrospective non-interventional cohort study. Mepolizumab patients enrolled in the GAN registry were evaluated with results being described in two different data sets: Cohort 1 (n=131) started on mepolizumab when the patients entered the registry. Results were reported after 4 months of therapy. Patients in Cohort 2 (n=220) were on treatment with mepolizumab at the time of enrollment and follow-up data were collected after a further year of treatment. Outcome measures included asthma control, lung function, disease symptoms, OCS use, and exacerbations.Results: Patients enrolled in the registry who started on mepolizumab in
Published: 2023

6. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023
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7. Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update

Author: Levy, Mark L., Bacharier, Leonard B., Bateman, Eric, Boulet, Louis Philippe, Brightling, Chris, Buhl, Roland, Brusselle, Guy, Cruz, Alvaro A., Drazen, Jeffrey M., Duijts, Liesbeth, Fleming, Louise, Inoue, Hiromasa, Ko, Fanny W.S., Krishnan, Jerry A., Mortimer, Kevin, Pitrez, Paulo M., Sheikh, Aziz, Yorgancıoğlu, Arzu, Reddel, Helen K., Levy, Mark L., Bacharier, Leonard B., Bateman, Eric, Boulet, Louis Philippe, Brightling, Chris, Buhl, Roland, Brusselle, Guy, Cruz, Alvaro A., Drazen, Jeffrey M., Duijts, Liesbeth, Fleming, Louise, Inoue, Hiromasa, Ko, Fanny W.S., Krishnan, Jerry A., Mortimer, Kevin, Pitrez, Paulo M., Sheikh, Aziz, Yorgancıoğlu, Arzu, and Reddel, Helen K.
Abstract: The Global Initiative for Asthma (GINA) was established in 1993 by the World Health Organization and the US National Heart Lung and Blood Institute to improve asthma awareness, prevention and management worldwide. GINA develops and publishes evidence-based, annually updated resources for clinicians. GINA guidance is adopted by national asthma guidelines in many countries, adapted to fit local healthcare systems, practices, and resource availability. GINA is independent of industry, funded by the sale and licensing of its materials. This review summarizes key practical guidance for primary care from the 2022 GINA strategy report. It provides guidance on confirming the diagnosis of asthma using spirometry or peak expiratory flow. GINA recommends that all adults, adolescents and most children with asthma should receive inhaled corticosteroid (ICS)-containing therapy to reduce the risk of severe exacerbations, either taken regularly, or (for adults and adolescents with “mild” asthma) as combination ICS–formoterol taken as needed for symptom relief. For patients with moderate–severe asthma, the preferred regimen is maintenance-and-reliever therapy (MART) with ICS–formoterol. Asthma treatment is not “one size fits all”; GINA recommends individualized assessment, adjustment, and review of treatment. As many patients with difficult-to-treat or severe asthma are not referred early for specialist review, we provide updated guidance for primary care on diagnosis, further investigation, optimization and treatment of severe asthma across secondary and tertiary care. While the GINA strategy has global relevance, we recognize that there are special considerations for its adoption in low- and middle-income countries, particularly the current poor access to inhaled medications.
Published: 2023

8. Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study

Author: Schiffers,Caspar, Wouters,Emiel FM, Breyer-Kohansal,Robab, Buhl,Roland, Pohl,Wolfgang, Irvin,Charles G, Breyer,Marie-Kathrin, Hartl,Sylvia, Schiffers,Caspar, Wouters,Emiel FM, Breyer-Kohansal,Robab, Buhl,Roland, Pohl,Wolfgang, Irvin,Charles G, Breyer,Marie-Kathrin, and Hartl,Sylvia
Abstract: Caspar Schiffers,1 Emiel FM Wouters,1,2 Robab Breyer-Kohansal,1,3 Roland Buhl,4 Wolfgang Pohl,5 Charles G Irvin,6 Marie-Kathrin Breyer,1,7 Sylvia Hartl1,7,8 1Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; 2NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands; 3Department of Respiratory and Pulmonary Diseases, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria; 4Pulmonology Department, Mainz University Hospital, Mainz, Germany; 5Karl Landsteiner Gesellschaft, Institute for Clinical and Experimental Pneumology, Vienna, Austria; 6Pulmonary and Critical Care, Larner College of Medicine, University of Vermont, Burlington, VT, USA; 7Department of Respiratory and Pulmonary Diseases, Clinic Penzing, Vienna Healthcare Group, Vienna, Austria; 8Sigmund Freud University, Faculty for Medicine, Vienna, AustriaCorrespondence: Caspar Schiffers, Ludwig Boltzmann Institute for Lung Health, Vienna, 1140, Austria, Email caspar.schiffers@lunghealth.lbg.ac.atBackground: Asthma is a chronic heterogeneous respiratory disease involving differential pathophysiological pathways and consequently distinct asthma phenotypes.Objective and Methods: In the LEAD Study, a general population cohort (n=11.423) in Vienna ranging from 6â 82 years of age, we addressed the prevalence of asthma and explored inflammatory asthma phenotypes that included allergic and non-allergic asthma, and within these phenotypes, an eosinophilic (eosinophils â¥ 300 cells/Î¼L, or â¥ 150 cells/Î¼L in the presence of ICS medication) or non-eosinophilic (eosinophils < 300 cells/Î¼L, or < 150 cells/Î¼L in the presence of ICS) phenotype. In addition, we compared various factors related to biomarkers, body composition, lung function, and symptoms in control subjects versus subjects with current asthma (current doctorâs diagnosis of asthma).Results: An overall prevalence of 4.6% was observed for current asthma. Furthe
Published: 2023

9. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023
Full Text: View/download PDF

10. Development and validation of an electronic daily control score for asthma (e-DASTHMA):a real-world direct patient data study

Author: Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., and Bousquet, Jean
Abstract: Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high
Published: 2023

11. Patient-centered digital biomarkers for allergic respiratory diseases and asthma:The ARIA-EAACI approach – ARIA-EAACI Task Force Report

Author: Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
Abstract: Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed., Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
Published: 2023

12. Development and validation of an electronic daily control score for asthma (e-DASTHMA):a real-world direct patient data study

Author: Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., and Bousquet, Jean
Abstract: Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high
Published: 2023

13. European Respiratory Society guidelines for the diagnosis of asthma in adults

Author: Louis, Renaud, Satia, Imran, Ojanguren, Inigo, Schleich, Florence, Bonini, Matteo, Tonia, Thomy, Rigau, David, Brinke, Anne ten, Buhl, Roland, Loukides, Stelios, Kocks, Janwillem W. H., Boulet, Louis-Philippe, Bourdin, Arnaud, Coleman, Courtney, Needham, Karen, Thomas, Mike, Idzko, Marco, Papi, Alberto, Porsbjerg, Celeste, Schuermans, Daniel, Soriano, Joan B., Usmani, Omar S., Louis, Renaud, Satia, Imran, Ojanguren, Inigo, Schleich, Florence, Bonini, Matteo, Tonia, Thomy, Rigau, David, Brinke, Anne ten, Buhl, Roland, Loukides, Stelios, Kocks, Janwillem W. H., Boulet, Louis-Philippe, Bourdin, Arnaud, Coleman, Courtney, Needham, Karen, Thomas, Mike, Idzko, Marco, Papi, Alberto, Porsbjerg, Celeste, Schuermans, Daniel, Soriano, Joan B., and Usmani, Omar S.
Abstract: Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which results in both over- and under-diagnosis. A taskforce was set up by the European Respiratory Society to systematically review the literature on the diagnostic accuracy of tests used to diagnose asthma in adult patients and provide recommendations for clinical practice. The taskforce defined eight Population, Index, Comparator and Outcome questions that were assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach. The taskforce utilised the outcomes to develop an evidence-based diagnostic algorithm, with recommendations for a pragmatic guideline for everyday practice that was directed by real-life patient experiences. The taskforce supports the initial use of spirometry followed by bronchodilator reversibility testing (if airway obstruction is present). If initial spirometry fails to show obstruction, further tests should be performed in the following order: exhaled nitric oxide fraction, peak expiratory flow variability, or, in secondary care, bronchial challenge. We present the thresholds for each test that are compatible with a diagnosis of asthma in the presence of current symptoms. The taskforce reinforces spirometry as a priority and recognises the value of measuring blood eosinophils and serum immunoglobulin E to phenotype the patient. Measuring gas trapping by body plethysmography in patients with preserved forced expiratory volume in 1 s/forced vital capacity ratio deserves further attention. The taskforce draws attention to the difficulty of making a correct diagnosis in patients already receiving inhaled corticosteroids; the comorbidities that may obscure diagnosis; the importance of phenotyping; and the necessity of considering the patient experience in the diagnostic process.
Published: 2022

14. European Respiratory Society guidelines for the diagnosis of asthma in adults

Author: Louis, Renaud, Satia, Imran, Ojanguren, Inigo, Schleich, Florence, Bonini, Matteo, Tonia, Thomy, Rigau, David, Brinke, Anne ten, Buhl, Roland, Loukides, Stelios, Kocks, Janwillem W. H., Boulet, Louis-Philippe, Bourdin, Arnaud, Coleman, Courtney, Needham, Karen, Thomas, Mike, Idzko, Marco, Papi, Alberto, Porsbjerg, Celeste, Schuermans, Daniel, Soriano, Joan B., Usmani, Omar S., Louis, Renaud, Satia, Imran, Ojanguren, Inigo, Schleich, Florence, Bonini, Matteo, Tonia, Thomy, Rigau, David, Brinke, Anne ten, Buhl, Roland, Loukides, Stelios, Kocks, Janwillem W. H., Boulet, Louis-Philippe, Bourdin, Arnaud, Coleman, Courtney, Needham, Karen, Thomas, Mike, Idzko, Marco, Papi, Alberto, Porsbjerg, Celeste, Schuermans, Daniel, Soriano, Joan B., and Usmani, Omar S.
Abstract: Although asthma is very common, affecting 5-10% of the population, the diagnosis of asthma in adults remains a challenge in the real world, which results in both over- and under-diagnosis. A taskforce was set up by the European Respiratory Society to systematically review the literature on the diagnostic accuracy of tests used to diagnose asthma in adult patients and provide recommendations for clinical practice. The taskforce defined eight Population, Index, Comparator and Outcome questions that were assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach. The taskforce utilised the outcomes to develop an evidence-based diagnostic algorithm, with recommendations for a pragmatic guideline for everyday practice that was directed by real-life patient experiences. The taskforce supports the initial use of spirometry followed by bronchodilator reversibility testing (if airway obstruction is present). If initial spirometry fails to show obstruction, further tests should be performed in the following order: exhaled nitric oxide fraction, peak expiratory flow variability, or, in secondary care, bronchial challenge. We present the thresholds for each test that are compatible with a diagnosis of asthma in the presence of current symptoms. The taskforce reinforces spirometry as a priority and recognises the value of measuring blood eosinophils and serum immunoglobulin E to phenotype the patient. Measuring gas trapping by body plethysmography in patients with preserved forced expiratory volume in 1 s/forced vital capacity ratio deserves further attention. The taskforce draws attention to the difficulty of making a correct diagnosis in patients already receiving inhaled corticosteroids; the comorbidities that may obscure diagnosis; the importance of phenotyping; and the necessity of considering the patient experience in the diagnostic process.
Published: 2022

15. Costs and Clinical Consequences of Compliance with COPD GOLD Recommendations or National Guidelines Compared with Current Clinical Practice in Belgium, Germany, Sweden, and the United States

Author: Sethi,Sanjay, Wright,Antony, Hartgers-Gubbels,Elisabeth Sophia, Hechtner,Marlene, Clark,Brendan, Wright,Ciara, Langham,Sue, Buhl,Roland, Sethi,Sanjay, Wright,Antony, Hartgers-Gubbels,Elisabeth Sophia, Hechtner,Marlene, Clark,Brendan, Wright,Ciara, Langham,Sue, and Buhl,Roland
Abstract: Sanjay Sethi,1 Antony Wright,2 Elisabeth Sophia Hartgers-Gubbels,3 Marlene Hechtner,3 Brendan Clark,4 Ciara Wright,2 Sue Langham,2 Roland Buhl5 1Pulmonary/Critical Care/Sleep Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA; 2Maverex Ltd., Newcastle Upon Tyne, NE6 2HL, UK; 3Boehringer Ingelheim GmbH, Ingelheim Am Rhein, Germany; 4Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA; 5Pulmonary Department, Mainz University Hospital, Mainz, GermanyCorrespondence: Antony Wright, Maverex Ltd, Newcastle Upon Tyne, NE6 2HL, UK, Tel +44 (0) 161 4646838, Email antonywright@maverex.comPurpose: The objective of this study was to assess the clinical and cost benefits of treating patients with chronic obstructive pulmonary disease (COPD) according to global and national guidelines compared to real-life clinical practice in the United States and three European countries (Belgium, Germany, Sweden).Patients and Methods: A cost-consequence model was developed to compare current prescribing patterns with two alternative scenarios, the first aligned with the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2022) recommendations and the second with national guidelines. Costs and clinical outcomes were modeled for these alternative scenarios over a time horizon of one year, based on real-world evidence and health insurance data.Results: Current clinical practice in each of the countries was inconsistent with published recommendations. A redistribution to prescribing patterns according to global and national recommendations led to a substantial decrease in the use of inhaled corticosteroid (ICS) containing therapies of more than 80% and 44%, respectively. There was a reduced incidence of up to 16% of mild-to-moderate pneumonia and up to 29% of severe pneumonia. Exacerbations decreased across all countries apart from Sweden, where a small increase in the rate of exacerbations was due to the redistribution of some patients currently un
Published: 2022

16. Real-World Treatment of Patients Newly Diagnosed with Chronic Obstructive Pulmonary Disease: A Retrospective German Claims Data Analysis

Author: Buhl,Roland, Wilke,Thomas, Picker,Nils, Schmidt,Olaf, Hechtner,Marlene, Kondla,Anke, Maywald,Ulf, Vogelmeier,Claus F, Buhl,Roland, Wilke,Thomas, Picker,Nils, Schmidt,Olaf, Hechtner,Marlene, Kondla,Anke, Maywald,Ulf, and Vogelmeier,Claus F
Abstract: Roland Buhl,1 Thomas Wilke,2 Nils Picker,3 Olaf Schmidt,4 Marlene Hechtner,5 Anke Kondla,5 Ulf Maywald,6 Claus F Vogelmeier7 1Pulmonary Department, Mainz University Hospital, Mainz, Germany; 2IPAM e.V, Wismar, Germany; 3Cytel Inc - Ingress-Health HWM GmbH, Wismar, Germany; 4Pulmonary Group Practice, Koblenz, Germany; 5Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany; 6AOK PLUS, Dresden, Germany; 7Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR), Member of the German Center for Lung Research (DZL), Marburg, GermanyCorrespondence: Roland Buhl, Medizinische Klinik und Poliklinik - UniversitÃ¤tsmedizin der Johannes Gutenberg-UniversitÃ¤t Mainz, LangenbeckstraÃe 1, Mainz, 55131, Germany, Tel +49 6131 17 7271, Email roland.buhl@unimedizin-mainz.dePurpose: This study aimed to describe the real-world treatment of German incident COPD patients, compare that treatment with clinical guidelines, and provide insight into disease development after incident diagnosis. In addition, the economic burden of the disease by assessing COPD-related healthcare costs was described.Patients and Methods: Based on a German claims dataset, continuously insured individuals (04/2014-03/2019) aged 40 years or older with at least two incident pulmonologistâs diagnoses or one inpatient diagnosis of COPD (ICD-10-GM code J44.-; no respective diagnosis in a 12-month baseline period) were selected. Treatment patterns after incident diagnosis considering inhaled maintenance therapies identified by ATC codes (outpatient prescriptions) were analyzed. Prescription patterns were compared with recommendations of German COPD treatment guidelines. Severe exacerbations were assessed as hospitalizations with main diagnosis ICD-10-GM code J44.1. COPD-associated costs from the perspective of the health insurance fund AOK PLUS were calculated per patient-year (PY).Results: The sample comprised 17,464 incident COPD patients with a mean age of 71.5
Published: 2022

17. Real-World Multicenter Experience with Mepolizumab and Benralizumab in the Treatment of Uncontrolled Severe Eosinophilic Asthma Over 12 Months

Author: Kayser,Moritz Z, Drick,Nora, Milger,Katrin, Fuge,Jan, Kneidinger,Nikolaus, Korn,Stephanie, Buhl,Roland, Behr,JÃ¼rgen, Welte,Tobias, Suhling,Hendrik, Kayser,Moritz Z, Drick,Nora, Milger,Katrin, Fuge,Jan, Kneidinger,Nikolaus, Korn,Stephanie, Buhl,Roland, Behr,JÃ¼rgen, Welte,Tobias, and Suhling,Hendrik
Abstract: Moritz Z Kayser,1 Nora Drick,1 Katrin Milger,2,3 Jan Fuge,1,4 Nikolaus Kneidinger,2,3 Stephanie Korn,5 Roland Buhl,6 JÃ¼rgen Behr,2,3 Tobias Welte,1,4 Hendrik Suhling1 1Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; 2Department of Medicine V, University Hospital, LMU, Munich, Germany; 3Comprehensive Pneumology Center-Munich (CPCâM), Member of the German Center for Lung Research (DZL), Munich, Germany; 4Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; 5Clinical Research Centre for Respiratory Medicine, Mainz, Germany; 6Pulmonary Department, Mainz University Hospital, Mainz, GermanyCorrespondence: Moritz Z KayserDepartment of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Lower Saxony, GermanyTel +49Â 0511-532-3531Fax +49 511-532-161108Email kayser.moritz@mh-hannover.dePurpose: Treatment of severe eosinophilic asthma (SEA) has been revolutionized by the development of monoclonal antibodies targeting underlying immunological pathways of eosinophilic asthma. Two of the most frequently used antibodies in clinical practice are mepolizumab, targeting interleukin (IL) 5 and benralizumab, targeting the IL5 receptor alpha. The comparative treatment efficacy of these antibodies remains unclear, particularly regarding long-term outcomes.Patients and Methods: In this multicenter, retrospective study, we included 123 patients treated with mepolizumab and 64 patients treated with benralizumab for 12 months at one of three study sites in Germany. Data were collected at baseline and after 6 and 12 months of therapy. Endpoints were changes in pulmonary function (PF), exacerbation rate, oral corticosteroid (OCS) use and dose, asthma control test (ACT) score and fractional exhaled nitric oxide (FeNO) levels.Results: Both mepolizumab and benralizumab led to significant improvements in PF with an increase in media
Published: 2021

18. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2021
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19. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2021
Full Text: View/download PDF

20. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2021
Full Text: View/download PDF

21. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2021
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22. ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan-Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree E., Laune, Daniel, Lourenco, Olga M., Melen, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhan, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, D. Bateman, Eric, Bedard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana-Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne-Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean-Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean-Francois, Fuentes Perez, Jose M., Gemicioglu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, Rene Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki-Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michael, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mosges, Ralph, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Bjorn, Novellino, Ettore, Nyembue, Dieudonne, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Scholl, Isabella, Panzner, Peter, Park, Hae-Sim, Passalacqua, Gianni, Pepin, Jean-Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Soderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schunemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frederic, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stephane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2021
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23. Real-World Multicenter Experience with Mepolizumab and Benralizumab in the Treatment of Uncontrolled Severe Eosinophilic Asthma Over 12 Months

Author: Kayser,Moritz Z, Drick,Nora, Milger,Katrin, Fuge,Jan, Kneidinger,Nikolaus, Korn,Stephanie, Buhl,Roland, Behr,JÃ¼rgen, Welte,Tobias, Suhling,Hendrik, Kayser,Moritz Z, Drick,Nora, Milger,Katrin, Fuge,Jan, Kneidinger,Nikolaus, Korn,Stephanie, Buhl,Roland, Behr,JÃ¼rgen, Welte,Tobias, and Suhling,Hendrik
Abstract: Moritz Z Kayser,1 Nora Drick,1 Katrin Milger,2,3 Jan Fuge,1,4 Nikolaus Kneidinger,2,3 Stephanie Korn,5 Roland Buhl,6 JÃ¼rgen Behr,2,3 Tobias Welte,1,4 Hendrik Suhling1 1Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; 2Department of Medicine V, University Hospital, LMU, Munich, Germany; 3Comprehensive Pneumology Center-Munich (CPCâM), Member of the German Center for Lung Research (DZL), Munich, Germany; 4Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany; 5Clinical Research Centre for Respiratory Medicine, Mainz, Germany; 6Pulmonary Department, Mainz University Hospital, Mainz, GermanyCorrespondence: Moritz Z KayserDepartment of Respiratory Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Lower Saxony, GermanyTel +49Â 0511-532-3531Fax +49 511-532-161108Email kayser.moritz@mh-hannover.dePurpose: Treatment of severe eosinophilic asthma (SEA) has been revolutionized by the development of monoclonal antibodies targeting underlying immunological pathways of eosinophilic asthma. Two of the most frequently used antibodies in clinical practice are mepolizumab, targeting interleukin (IL) 5 and benralizumab, targeting the IL5 receptor alpha. The comparative treatment efficacy of these antibodies remains unclear, particularly regarding long-term outcomes.Patients and Methods: In this multicenter, retrospective study, we included 123 patients treated with mepolizumab and 64 patients treated with benralizumab for 12 months at one of three study sites in Germany. Data were collected at baseline and after 6 and 12 months of therapy. Endpoints were changes in pulmonary function (PF), exacerbation rate, oral corticosteroid (OCS) use and dose, asthma control test (ACT) score and fractional exhaled nitric oxide (FeNO) levels.Results: Both mepolizumab and benralizumab led to significant improvements in PF with an increase in media
Published: 2021

24. Cabbage and fermented vegetables:From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Author: Bousquet, Jean, Anto, Josep M., Czarlewski, Wienczyslawa, Haahtela, Tari, Fonseca, Susana C., Iaccarino, Guido, Blain, Hubert, Vidal, Alain, Sheikh, Aziz, Akdis, Cezmi A., Zuberbier, Torsten, Hamzah Abdul Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Al-Zahab Bassam, Abou, Alburdan, Hussam, Aldrey-Palacios, Oscar, Alvarez Cuesta, Emilio, Alwan Salman, Hiba, Alzaabi, Ashraf, Amade, Salma, Ambrocio, Gene, Angles, Rosana, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep, Ara Bardajo, Paula, Arasi, Stefania, Arshad, Hasan, Cristina Artesani, Maria, Asayag, Estrella, Avolio, Francesca, Buhl, Roland, Dahl, Ronald, Li, Jing, Malling, Hans Jørgen, Pedersen, Søren, Poulsen, Lars, Suppli Ulrik, Charlotte, Walker, Samantha, Wang, De Yun, Zhang, Luo, Bousquet, Jean, Anto, Josep M., Czarlewski, Wienczyslawa, Haahtela, Tari, Fonseca, Susana C., Iaccarino, Guido, Blain, Hubert, Vidal, Alain, Sheikh, Aziz, Akdis, Cezmi A., Zuberbier, Torsten, Hamzah Abdul Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Al-Zahab Bassam, Abou, Alburdan, Hussam, Aldrey-Palacios, Oscar, Alvarez Cuesta, Emilio, Alwan Salman, Hiba, Alzaabi, Ashraf, Amade, Salma, Ambrocio, Gene, Angles, Rosana, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep, Ara Bardajo, Paula, Arasi, Stefania, Arshad, Hasan, Cristina Artesani, Maria, Asayag, Estrella, Avolio, Francesca, Buhl, Roland, Dahl, Ronald, Li, Jing, Malling, Hans Jørgen, Pedersen, Søren, Poulsen, Lars, Suppli Ulrik, Charlotte, Walker, Samantha, Wang, De Yun, and Zhang, Luo
Abstract: Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.
Published: 2021

25. Eosinophilic and Noneosinophilic Asthma:An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Author: Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., Price, David B., Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., and Price, David B.
Abstract: Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). Results: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. Interpretation: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessi
Published: 2021

26. Eosinophilic and Noneosinophilic Asthma:An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Author: Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., Price, David B., Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., and Price, David B.
Abstract: Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). Results: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. Interpretation: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessi
Published: 2021

27. ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020)

Author: Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A., Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C., Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bennoor, Kazi S., Berghea, Elena Camelia, Bergmann, Karl Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, Giorgio Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F., Ko, Fanny W., Koskinen, Seppo, Kowalski, Marek L., Kraxner, Helga, Kudlay, Dmitry, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H., Le, Lan T., Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R., Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O’Byrne, Paul, O’Hehir, Robyn, O’Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Panzner, Petr, Papadopoulos, Nikos G., Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A., Puggioni, Francesca, Regateiro, Frederico S., Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Soto-Martinez, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary W.K., Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, Agache, Ioana, Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A., Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C., Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bennoor, Kazi S., Berghea, Elena Camelia, Bergmann, Karl Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, Giorgio Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F., Ko, Fanny W., Koskinen, Seppo, Kowalski, Marek L., Kraxner, Helga, Kudlay, Dmitry, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H., Le, Lan T., Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R., Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O’Byrne, Paul, O’Hehir, Robyn, O’Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Panzner, Petr, Papadopoulos, Nikos G., Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A., Puggioni, Francesca, Regateiro, Frederico S., Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Soto-Martinez, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary W.K., Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, and Agache, Ioana
Published: 2021

28. ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020)

Author: Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A., Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C., Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bennoor, Kazi S., Berghea, Elena Camelia, Bergmann, Karl Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, Giorgio Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F., Ko, Fanny W., Koskinen, Seppo, Kowalski, Marek L., Kraxner, Helga, Kudlay, Dmitry, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H., Le, Lan T., Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R., Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O’Byrne, Paul, O’Hehir, Robyn, O’Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Panzner, Petr, Papadopoulos, Nikos G., Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A., Puggioni, Francesca, Regateiro, Frederico S., Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Soto-Martinez, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary W.K., Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, Agache, Ioana, Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A., Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C., Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bennoor, Kazi S., Berghea, Elena Camelia, Bergmann, Karl Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, Giorgio Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J., Fonseca, Joao A., Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F., Ko, Fanny W., Koskinen, Seppo, Kowalski, Marek L., Kraxner, Helga, Kudlay, Dmitry, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H., Le, Lan T., Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R., Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O’Byrne, Paul, O’Hehir, Robyn, O’Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Panzner, Petr, Papadopoulos, Nikos G., Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A., Puggioni, Francesca, Regateiro, Frederico S., Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Soto-Martinez, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary W.K., Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, and Agache, Ioana
Published: 2021

29. ARIA-EAACI statement on Asthma and COVID-19 (June 2, 2020)

Author: CTI Research, CTI, MS Dermatologie/Allergologie, Infection & Immunity, Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A, Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C, Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J, Anto, Josep M, Bachert, Claus, Bateman, Eric D, Bennoor, Kazi S, Berghea, Emilia Camelia, Bergmann, Karl-Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis-Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, G Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J, Fonseca, Joao A, Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan-Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F, Ko, Fanny W, Koskinen, Seppo, Kowalski, Marek L, Kraxner, Helga, Kudlay, Dmitri, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H, Le, Lan T, Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R, Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O'Byrne, Paul, O'Hehir, Robyn, O'Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L, Panzner, Petr, Papadopoulos, Nikos G, Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A, Puggioni, Francesca, Regateiro, Frederico S, Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary Wk, Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, Agache, Ioana, CTI Research, CTI, MS Dermatologie/Allergologie, Infection & Immunity, Bousquet, Jean, Jutel, Marek, Akdis, Cezmi A, Klimek, Ludger, Pfaar, Oliver, Nadeau, Kari C, Eiwegger, Thomas, Bedbrook, Anna, Ansotegui, Ignacio J, Anto, Josep M, Bachert, Claus, Bateman, Eric D, Bennoor, Kazi S, Berghea, Emilia Camelia, Bergmann, Karl-Christian, Blain, Hubert, Bonini, Mateo, Bosnic-Anticevich, Sinthia, Boulet, Louis-Philippe, Brussino, Luisa, Buhl, Roland, Camargos, Paulo, Canonica, G Walter, Cardona, Victoria, Casale, Thomas, Chinthrajah, Sharon, Akdis, Mübeccel, Chivato, Tomas, Christoff, George, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Del Giacco, Stefano, Du, Hui, El-Gamal, Yehia, Fokkens, Wytske J, Fonseca, Joao A, Gao, Yadong, Gaga, Mina, Gemicioglu, Bilun, Gotua, Maia, Haahtela, Tari, Halpin, David, Hamelmann, Eckard, Hoffmann-Sommergruber, Karin, Humbert, Marc, Ilina, Nataliya, Ivancevich, Juan-Carlos, Joos, Guy, Khaitov, Musa, Kirenga, Bruce, Knol, Edward F, Ko, Fanny W, Koskinen, Seppo, Kowalski, Marek L, Kraxner, Helga, Kudlay, Dmitri, Kuna, Piotr, Kupczyk, Maciej, Kvedariene, Violeta, Abdul Latiff, Amir H, Le, Lan T, Levin, Michael, Larenas-Linnemann, Desiree, Louis, Renaud, Masjedi, Mohammad R, Melén, Erik, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Morais-Almeida, Mario, Mullol, Joaquim, Namazova, Leyla, Neffen, Hugo, Nunes, Elisabete, O'Byrne, Paul, O'Hehir, Robyn, O'Mahony, Liam, Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L, Panzner, Petr, Papadopoulos, Nikos G, Passalacqua, Gianni, Patella, Vincenzo, Pawankar, Ruby, Pham-Thi, Nhân, Pigearias, Bernard, Popov, Todor A, Puggioni, Francesca, Regateiro, Frederico S, Rolla, Giovanni, Rottem, Menachem, Samolinski, Boleslaw, Sastre, Joaquin, Schwarze, Jurgen, Sheikh, Aziz, Scichilone, Nicola, Soto-Quiros, Manuel, Sova, Milan, Nicola, Stefania, Stelmach, Rafael, Suppli-Ulrik, Charlotte, Taborda-Barata, Luis, To, Teresa, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Usmani, Omar, Valiulis, Arunas, Ventura, Maria Teresa, Viegi, Giovanni, Vontetsianos, Theodor, Wang, De Yun, Williams, Sian, Wong, Gary Wk, Yorgancioglu, Arzu, Zernotti, Mario, Zidarn, Mihaela, Zuberbier, Torsten, and Agache, Ioana
Published: 2021

30. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.

Author: Smits, Jacqueline M, Smits, Jacqueline M, Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M, Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, Van Raemdonck, Dirk, Smits, Jacqueline M, Smits, Jacqueline M, Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M, Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, and Van Raemdonck, Dirk
Abstract: The aim of this study was to investigate whether there is an impact of donation rates on the quality of lungs used for transplantation and whether donor lung quality affects post-transplant outcome in the current Lung Allocation Score era. All consecutive adult LTx performed in Eurotransplant (ET) between January 2012 and December 2016 were included (N = 3053). Donors used for LTx in countries with high donation rate were younger (42% vs. 33% ≤45 years, P < 0.0001), were less often smokers (35% vs. 46%, P < 0.0001), had more often clear chest X-rays (82% vs. 72%, P < 0.0001), had better donor oxygenation ratios (20% vs. 26% with PaO2 /FiO2 ≤ 300 mmHg, P < 0.0001), and had better lung donor score values (LDS; 28% vs. 17% with LDS = 6, P < 0.0001) compared with donors used for LTx in countries with low donation rate. Survival rates for the groups LDS = 6 and ≥7 at 5 years were 69.7% and 60.9% (P = 0.007). Lung donor quality significantly impacts on long-term patient survival. Countries with a low donation rate are more oriented to using donor lungs with a lesser quality compared to countries with a high donation rate. Instead of further stretching donor eligibility criteria, the full potential of the donor pool should be realized.
Published: 2020

31. Switch from IL-5 to IL-5-Receptor α Antibody Treatment in Severe Eosinophilic Asthma

Author: Drick,Nora, Milger,Katrin, Seeliger,Benjamin, Fuge,Jan, Korn,Stephanie, Buhl,Roland, Schuhmann,Maren, Herth,Felix, Kendziora,Benjamin, Behr,Juergen, Kneidinger,Nikolaus, Bergmann,Karl-Christian, Taube,Christian, Welte,Tobias, Suhling,Hendrik, Drick,Nora, Milger,Katrin, Seeliger,Benjamin, Fuge,Jan, Korn,Stephanie, Buhl,Roland, Schuhmann,Maren, Herth,Felix, Kendziora,Benjamin, Behr,Juergen, Kneidinger,Nikolaus, Bergmann,Karl-Christian, Taube,Christian, Welte,Tobias, and Suhling,Hendrik
Abstract: Nora Drick,1,* Katrin Milger,2,* Benjamin Seeliger,1 Jan Fuge,1 Stephanie Korn,3 Roland Buhl,3 Maren Schuhmann,4 Felix Herth,4 Benjamin Kendziora,5 Juergen Behr,2 Nikolaus Kneidinger,2 Karl-Christian Bergmann,5 Christian Taube,6 Tobias Welte,1 Hendrik Suhling1 1Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; 2Department of Internal Medicine V, Ludwig-Maximilians University of Munich (LMU), Munich, Germany; 3Pulmonary Department, Mainz University Hospital, Mainz, Germany; 4Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany; 5Allergy-Centre-Charité, Charité – Universitätsmedizin Berlin, Berlin, Germany; 6Department of Pulmonary Medicine, University Hospital Essen – Ruhrlandklinik, Essen, Germany*These authors contributed equally to this workCorrespondence: Hendrik Suhling Email suhling.hendrik@mh-hannover.deBackground: Anti-IL-5 antibodies represent an established therapy for severe eosinophilic asthma (SEA), but some patients show inadequate response. The objective of this study was to assess the effects of a switch to anti-IL-5Rα therapy in patients with inadequate response to anti-IL-5 therapy.Methods: In this retrospective multi-centre, real-life study, we analysed all SEA patients switched from anti-IL-5 to anti-IL-5Rα therapy due to inadequate response or intolerability. Pulmonary function tests, blood gas analyses, asthma control tests (ACT) and oral corticosteroid (OCS) usage were analysed and compared at three timepoints: baseline (BL, before anti-IL-5 therapy), timepoint 1 (T1, under anti-IL-5 therapy) and timepoint 2 (T2, under anti-IL-5Rα therapy).Results: Of 665 patients treated with anti-IL-5 antibodies, 70 were switched to anti-IL-5Rα and 60 were included in the analysis. Median treatment duration was 8 months [IQR 5; 15] for anti-IL-5 and 5 months [IQR 4; 6] for anti-IL
Published: 2020

32. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant - a historical prospective study.

Author: Smits, Jacqueline M, Smits, Jacqueline M, Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M, Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, Van Raemdonck, Dirk, Smits, Jacqueline M, Smits, Jacqueline M, Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M, Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, and Van Raemdonck, Dirk
Abstract: The aim of this study was to investigate whether there is an impact of donation rates on the quality of lungs used for transplantation and whether donor lung quality affects post-transplant outcome in the current Lung Allocation Score era. All consecutive adult LTx performed in Eurotransplant (ET) between January 2012 and December 2016 were included (N = 3053). Donors used for LTx in countries with high donation rate were younger (42% vs. 33% ≤45 years, P < 0.0001), were less often smokers (35% vs. 46%, P < 0.0001), had more often clear chest X-rays (82% vs. 72%, P < 0.0001), had better donor oxygenation ratios (20% vs. 26% with PaO2 /FiO2 ≤ 300 mmHg, P < 0.0001), and had better lung donor score values (LDS; 28% vs. 17% with LDS = 6, P < 0.0001) compared with donors used for LTx in countries with low donation rate. Survival rates for the groups LDS = 6 and ≥7 at 5 years were 69.7% and 60.9% (P = 0.007). Lung donor quality significantly impacts on long-term patient survival. Countries with a low donation rate are more oriented to using donor lungs with a lesser quality compared to countries with a high donation rate. Instead of further stretching donor eligibility criteria, the full potential of the donor pool should be realized.
Published: 2020

33. Switch from IL-5 to IL-5-Receptor α Antibody Treatment in Severe Eosinophilic Asthma

Author: Drick,Nora, Milger,Katrin, Seeliger,Benjamin, Fuge,Jan, Korn,Stephanie, Buhl,Roland, Schuhmann,Maren, Herth,Felix, Kendziora,Benjamin, Behr,Juergen, Kneidinger,Nikolaus, Bergmann,Karl-Christian, Taube,Christian, Welte,Tobias, Suhling,Hendrik, Drick,Nora, Milger,Katrin, Seeliger,Benjamin, Fuge,Jan, Korn,Stephanie, Buhl,Roland, Schuhmann,Maren, Herth,Felix, Kendziora,Benjamin, Behr,Juergen, Kneidinger,Nikolaus, Bergmann,Karl-Christian, Taube,Christian, Welte,Tobias, and Suhling,Hendrik
Abstract: Nora Drick,1,* Katrin Milger,2,* Benjamin Seeliger,1 Jan Fuge,1 Stephanie Korn,3 Roland Buhl,3 Maren Schuhmann,4 Felix Herth,4 Benjamin Kendziora,5 Juergen Behr,2 Nikolaus Kneidinger,2 Karl-Christian Bergmann,5 Christian Taube,6 Tobias Welte,1 Hendrik Suhling1 1Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany; 2Department of Internal Medicine V, Ludwig-Maximilians University of Munich (LMU), Munich, Germany; 3Pulmonary Department, Mainz University Hospital, Mainz, Germany; 4Department of Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany; 5Allergy-Centre-Charité, Charité – Universitätsmedizin Berlin, Berlin, Germany; 6Department of Pulmonary Medicine, University Hospital Essen – Ruhrlandklinik, Essen, Germany*These authors contributed equally to this workCorrespondence: Hendrik Suhling Email suhling.hendrik@mh-hannover.deBackground: Anti-IL-5 antibodies represent an established therapy for severe eosinophilic asthma (SEA), but some patients show inadequate response. The objective of this study was to assess the effects of a switch to anti-IL-5Rα therapy in patients with inadequate response to anti-IL-5 therapy.Methods: In this retrospective multi-centre, real-life study, we analysed all SEA patients switched from anti-IL-5 to anti-IL-5Rα therapy due to inadequate response or intolerability. Pulmonary function tests, blood gas analyses, asthma control tests (ACT) and oral corticosteroid (OCS) usage were analysed and compared at three timepoints: baseline (BL, before anti-IL-5 therapy), timepoint 1 (T1, under anti-IL-5 therapy) and timepoint 2 (T2, under anti-IL-5Rα therapy).Results: Of 665 patients treated with anti-IL-5 antibodies, 70 were switched to anti-IL-5Rα and 60 were included in the analysis. Median treatment duration was 8 months [IQR 5; 15] for anti-IL-5 and 5 months [IQR 4; 6] for anti-IL
Published: 2020

34. ARIA digital anamorphosis:Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. 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Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2020

35. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author: Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., 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Aris, Palaniappan, S. 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Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, 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Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zubrinich, Celia
Abstract: Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
Published: 2020

36. ARIA digital anamorphosis:Digital transformation of health and care in airway diseases from research to practice

Author: Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, Zidarn, Mihaela, Bousquet, Jean, Anto, Josep M., Bachert, Claus, Haahtela, Tari, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Walter Canonica, G., Cardona, Victoria, Costa, Elisio, Cruz, Alvaro A., Erhola, Marina, Fokkens, Wytske J., Fonseca, Joao A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga M., Melén, Erik, Mullol, Joaquim, Niedoszytko, Marek, Odemyr, Mikaëla, Okamoto, Yoshitaka, Papadopoulos, Nikos G., Patella, Vincenzo, Pfaar, Oliver, Pham-Thi, Nhân, Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Sofiev, Mikhail, Suppli Ulrik, Charlotte, Todo-Bom, Ana, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Yorgancioglu, Arzu, Agache, Ioana, Akdis, Cezmi A., Almeida, Rute, Ansotegui, Ignacio J., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagaña, Xavier, D. Bateman, Eric, Bédard, Annabelle, Bedolla-Barajas, Martin, Becker, Sven, Bennoor, Kazi S., Benveniste, Samuel, Bergmann, Karl C., Bewick, Michael, Bialek, Slawomir, E. Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Matteo, Bonniaud, Philippe, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Boussery, Koen, Braido, Fluvio, Briedis, Vitalis, Briggs, Andrew, Brightling, Christopher E., Brozek, Jan, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Buonaiuto, Roland, Calderon, Moises A., Camargos, Paulo, Camuzat, Thierry, Caraballo, Luis, Carriazo, Ana Maria, Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., H. Chavannes, Niels, Chkhartishvili, Ekaterine, Chu, Derek K., Cingi, Cemal, Correia de Sousa, Jaime, Costa, David J., Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejan, Dauvilliers, Yves, De Feo, Giulia, De Vries, Govert, Devillier, Philippe, Di Capua, Stefania, Dray, Gerard, Dubakiene, Ruta, Durham, Stephen R., Dykewicz, Marc, Ebisawa, Motohiro, Gaga, Mina, El-Gamal, Yehia, Heffler, Enrico, Emuzyte, Regina, Farrell, John, Fauquert, Jean Luc, Fiocchi, Alessandro, Fink-Wagner, Antje, Fontaine, Jean François, Fuentes Perez, José M., Gemicioğlu, Bilun, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gevaert, Philippe, Gomez, René Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, Huerta Villalobos, Yunuen R., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Iinuma, Tomohisa, Jassem, Ewa, Joos, Guy, Jung, Ki Suck, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Musa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kouznetsov, Rostislav, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, La Grutta, Stefania, Leonardini, Lisa, Ljungberg, Henrik, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Lopes-Pereira, Catarina, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Mahboub, Bassam, Makris, Michaël, Malva, Joao, Manning, Patrick, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Carreiro-Martins, Pedro, Makela, Mika, Mathieu-Dupas, Eve, Maurer, Marcus, De Manuel Keenoy, Esteban, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Micheli, Yann, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mitsias, Dimitirios I., Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralph, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Nordlund, Björn, Novellino, Ettore, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle L., Orlando, Valentina, Ouedraogo, Solange, Palamarchuk, Julia, Pali-Schöll, Isabella, Panzner, Peter, Park, Hae Sim, Passalacqua, Gianni, Pépin, Jean Louis, Paulino, Ema, Pawankar, Ruby, Phillips, Jim, Picard, Robert, Pinnock, Hilary, Plavec, Davor, Popov, Todor A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Psarros, Fotis, Pugin, Benoit, Puggioni, Francesca, Quinones-Delgado, Pablo, Raciborski, Filip, Rajabian-Söderlund, Rojin, Regateiro, Frederico S., Reitsma, Sietze, Rivero-Yeverino, Daniela, Roberts, Graham, Roche, Nicolas, Rodriguez-Zagal, Erendira, Roller-Wirnsberger, Regina E., Rosario, Nelson, Romano, Antonino, Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sastre, Joaquin, Scadding, Glenis K., Scheire, Sophie, Schmid-Grendelmeier, Peter, Schünemann, Holger J., Sarquis Serpa, Faradiba, Shamji, Mohamed, Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spertini, François, Spranger, Otto, Stellato, Cristiana, Stelmach, Rafael, Thibaudon, Michel, To, Teresa, Toumi, Mondher, Usmani, Omar, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Pereira, Marilyn Urrutia, van der Kleij, Rianne, Van Eerd, Michiel, Vandenplas, Olivier, Vasankari, Tuula, Vaz Carneiro, Antonio, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yusuf, Osman M., Zar, Heather J., Zeng, Stéphane, Zernotti, Mario E., Zhang, Luo, Shan Zhong, Nan, and Zidarn, Mihaela
Abstract: Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
Published: 2020

37. Exceptional LAS Requests in Eurotransplant: Analysis of an 8-year Effort to Improve Lung Allocation for Precarious Patients

Author: Vos, Robin, Smits, Jacqueline M A J.M., Hoek, Rogier, Green, Dave, Evrard, Patrick, Knoop, Christiane, Verleden, Geert, Rondelet, Benoît, Kwakkel-vanErp, J.M., Seghers, Leonard, van Kessel, Diana, Luijk, Bart, Verschuuren, Erik, Lang, György, Hoetzenecker, Konrad, Laufer, Gúnther, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Deuse, Tobias, Buhl, Roland, Witt, Christian, Gottlieb, Jens, Vos, Robin, Smits, Jacqueline M A J.M., Hoek, Rogier, Green, Dave, Evrard, Patrick, Knoop, Christiane, Verleden, Geert, Rondelet, Benoît, Kwakkel-vanErp, J.M., Seghers, Leonard, van Kessel, Diana, Luijk, Bart, Verschuuren, Erik, Lang, György, Hoetzenecker, Konrad, Laufer, Gúnther, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Deuse, Tobias, Buhl, Roland, Witt, Christian, and Gottlieb, Jens
Abstract: PURPOSE: Following introduction of the lung allocation score (LAS) in 2011, Eurotransplant member centers can apply for an exceptional LAS (eLAS) if the calculated LAS insufficiently reflects the perceived transplant benefit for a patient, specifically in case of primary pulmonary hypertension group 1 and 4; combined lung+non-renal transplantation; rare diseases; or extracorporeal support. Each eLAS proposal is evaluated by a LAS Review Board, consisting of ≥3 lung transplant experts, which subsequently declines or approves the eLAS request in consensus of ≥3 votes. In case of a lower than accepted score, predefined business rules to assign LAS percentiles are used. METHODS: A retrospective analysis of all eLAS requests in Eurotransplant from December 2011 until September 2019. RESULTS: Overall, 5183 lung transplants (deceased donors) were performed and 420 eLAS requests were made (Germany 52%, Netherlands 18%, Austria 18%, Belgium 13%), of which 116 (28%) were approved. Most eLAS requests concerned group B/Pulmonary vascular disease (44%), followed by group C/Cystic fibrosis or immunodeficiency disorder (28%), then group D/Restrictive lung disease (15%) and finally group A/Obstructive lung disease (11%); whereas 10 patients (2%) were not classified. The proportion of accepted eLAS requests significantly differed between countries (Germany 25%, Netherlands 37%, Austria 20%, Belgium 36%) (p=0.042). eLAS requests decreased in the Netherlands following its LAS introduction in 2014 (2011-2014 mean 13/yr vs. 2015-2019 mean 4.6/yr; p=0.060). However, since 2015 an overall annual increasing number of eLAS requests is seen, with doubling of the eLAS requests in 2018 vs. 2015, but no difference in acceptance rate (2015-2018: 22.4%) (Figure). Acceptance rates were 38% for Group B, 21% for Group C, 20% for Group D and 11% for Group A. CONCLUSION: The observed variations require further investigation to optimize lung allocation for specific patient populations in Eurotransplant, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2020

38. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant – a historical prospective study

Author: Smits, Jacqueline M A J.M., Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna J.M., Vos, Robin, Verleden, Geert, Rondelet, Benoît, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, Van Raemdonck, Dirk, Smits, Jacqueline M A J.M., Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna J.M., Vos, Robin, Verleden, Geert, Rondelet, Benoît, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, and Van Raemdonck, Dirk
Abstract: The aim of this study was to investigate whether there is an impact of donation rates on the quality of lungs used for transplantation and whether donor lung quality affects post-transplant outcome in the current Lung Allocation Score era. All consecutive adult LTx performed in Eurotransplant (ET) between January 2012 and December 2016 were included (N = 3053). Donors used for LTx in countries with high donation rate were younger (42% vs. 33% ≤45 years, P < 0.0001), were less often smokers (35% vs. 46%, P < 0.0001), had more often clear chest X-rays (82% vs. 72%, P < 0.0001), had better donor oxygenation ratios (20% vs. 26% with PaO2/FiO2 ≤ 300 mmHg, P < 0.0001), and had better lung donor score values (LDS; 28% vs. 17% with LDS = 6, P < 0.0001) compared with donors used for LTx in countries with low donation rate. Survival rates for the groups LDS = 6 and ≥7 at 5 years were 69.7% and 60.9% (P = 0.007). Lung donor quality significantly impacts on long-term patient survival. Countries with a low donation rate are more oriented to using donor lungs with a lesser quality compared to countries with a high donation rate. Instead of further stretching donor eligibility criteria, the full potential of the donor pool should be realized., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2020

39. Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Author: Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zubrinich, Celia, Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zubrinich, Celia
Abstract: Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
Published: 2020

40. A Non-Interventional Study of Tiotropium/Olodaterol versus Any Triple Combination Therapy for Chronic Obstructive Pulmonary Disease: The EVELUT® Study Protocol

Author: Buhl,Roland, Dreher,Michael, Korn,Stephanie, Taube,Christian, Stock,Christian, Zehendner,Christoph M, Kondla,Anke, Vogelmeier,Claus F, Buhl,Roland, Dreher,Michael, Korn,Stephanie, Taube,Christian, Stock,Christian, Zehendner,Christoph M, Kondla,Anke, and Vogelmeier,Claus F
Abstract: Roland Buhl,1 Michael Dreher,2 Stephanie Korn,1 Christian Taube,3 Christian Stock,4 Christoph M Zehendner,5 Anke Kondla,5 Claus F Vogelmeier6 1Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany; 2Clinic of Cardiology, Pneumology, Angiology and Internal Medicine Intensive Care, University Hospital RWTH Aachen, Aachen, Germany; 3Clinic for Pneumonology, University Medicine Essen – Ruhrlandklinik, Essen, Germany; 4Biostatistics + Data Sciences Corp, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; 5HP Country Medical Affairs, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany; 6Department of Pneumology, University Hospital of Giessen and Marburg, Member of the German Center for Lung Research (DZL), Marburg, GermanyCorrespondence: Roland BuhlPulmonary Department, Johannes Gutenberg University Mainz, Langenbeckstraße 1, Mainz D-55131, GermanyTel +49 6131 17-7271Email roland.buhl@unimedizin-mainz.deBackground: The Global Initiative for Chronic Obstructive Lung Disease 2020 report recommends that patients with chronic obstructive pulmonary disease (COPD) suffering from persistent dyspnea, despite long-acting β2-agonist (LABA)/inhaled corticosteroid (ICS) maintenance therapy, are switched to either a long-acting muscarinic antagonist (LAMA)/LABA combination regimen or LAMA/LABA/ICS triple therapy. However, to date, no studies have investigated the direct switch from LABA/ICS to LAMA/LABA therapy—instead of switching to triple therapy—in a prospective, real-world, non-interventional setting.Methods: EVELUT® (NCT03954132) is an ongoing, prospective, open-label, multicenter, non-interventional study comparing the once-daily fixed-dose combination of tiotropium and olodaterol (tio/olo) versus any triple therapy (LAMA/LABA/ICS) in patients with COPD who are symptomatic despite LABA/ICS maintenance therapy. Patients with acute or frequent COPD
Published: 2020

41. Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD

Author: Andreas,Stefan, McGarvey,Lorcan, Bothner,Ulrich, Trampisch,Matthias, de la Hoz,Alberto, FleÅ¾ar,Matjaz, Buhl,Roland, Alter,Peter, Andreas,Stefan, McGarvey,Lorcan, Bothner,Ulrich, Trampisch,Matthias, de la Hoz,Alberto, FleÅ¾ar,Matjaz, Buhl,Roland, and Alter,Peter
Abstract: Stefan Andreas,1,2 Lorcan McGarvey,3 Ulrich Bothner,4 Matthias Trampisch,4 Alberto de la Hoz,4 Matjaz FleÅ¾ar,5 Roland Buhl,6 Peter Alter7 1Department of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany; 2LungClinic Immenhausen, Immenhausen, Germany, Member of the German Center for Lung Research (DZL); 3Queen’s University Belfast, Belfast, UK; 4Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 5Klinika Golnik, Golnik, Slovenia; 6Pulmonary Department, Johannes Gutenberg University Mainz, Mainz, Germany; 7Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg (UMR); Member of the German Center for Lung Research (DZL), Marburg, GermanyCorrespondence: Stefan AndreasDepartment of Cardiology and Pneumology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen, GermanyTel +49 05673 501 1112Fax +49 05673-501-1101Email stefan.andreas@med.uni-goettingen.deIntroduction: Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are established maintenance bronchodilator treatments for chronic obstructive pulmonary disease (COPD) with the potential to increase heart rate (HR) and impact blood pressure (BP). While previous studies indicate that HR and BP are not negatively influenced by tiotropium or olodaterol monotherapy, the effect of tiotropium/olodaterol has not been evaluated. We report a post hoc analysis of the effect of dual bronchodilation with tiotropium/olodaterol versus monocomponents on HR and BP in patients with moderate-to-very-severe COPD included in the large TONADO® study.Methods: The TONADO® trials (1237.5 [NCT01431274] and 1237.6 [NCT01431287]) were two replicate, randomized, double-blind, parallel-group, 52-week, Phase III trials that compared tiotropium/olodaterol (5/5 μg and 2.5/5 μg) with tiotropium (5 μg and 2.5 μg) and olodaterol
Published: 2020

42. Impact of donor lung quality on post-transplant recipient outcome in the Lung Allocation Score era in Eurotransplant – a historical prospective study

Author: Longziekten, Infection & Immunity, Smits, Jacqueline M., Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M., Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, Van Raemdonck, Dirk, Longziekten, Infection & Immunity, Smits, Jacqueline M., Gottlieb, Jens, Verschuuren, Erik, Evrard, Patrick, Hoek, Rogier, Knoop, Christiane, Lang, György, Kwakkel-van Erp, Johanna M., Vos, Robin, Verleden, Geert, Rondelet, Benoit, Hoefer, Daniel, Langer, Frank, Schramm, Rene, Hoetzenecker, Konrad, van Kessel, Diana, Luijk, Bart, Seghers, Leonard, Deuse, Tobias, Buhl, Roland, Witt, Christian, Strelniece, Agita, Green, Dave, de Vries, Erwin, Laufer, Guenter, and Van Raemdonck, Dirk
Published: 2020

43. Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)A, Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)B, Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)D, Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)E, Österreichische Gesellschaft für Pneumologie (ÖGP)F in co-operation with the German, Austrian, and Swiss ARIA groupsG, and the European Academy of Allergy and Clinical Immunology (EAACI)H

Author: CTI, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Klimek, Ludger, Pfaar, Oliver, Worm, Margitta, Eiwegger, Thomas, Hagemann, Jan, Ollert, Markus, Untersmayr, Eva, Hoffmann-Sommergruber, Karin, Vultaggio, Alessandra, Agache, Ioana, Bavbek, Sevim, Bossios, Apostolos, Casper, Ingrid, Chan, Susan, Chatzipetrou, Alexia, Vogelberg, Christian, Firinu, Davide, Kauppi, Paula, Kolios, Antonios, Kothari, Akash, Matucci, Andrea, Palomares, Oscar, Szépfalusi, Zsolt, Pohl, Wolfgang, Hötzenecker, Wolfram, Rosenkranz, Alexander R, Bergmann, Karl-Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen, Darsow, Ulf, Keil, Thomas, Kleine-Tebbe, Jörg, Lau, Susanne, Maurer, Marcus, Merk, Hans, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Jappe, Uta, Rabe, Klaus F, Rabe, Uta, Vogelmeier, Claus, Biedermann, Tilo, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Freudelsperger, Laura, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Tomazic, Peter-Valentin, Aberer, Werner, Fink-Wagner, Antje-Henriette, Horak, Fritz, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Roller-Wirnsberger, Regina, Spranger, Otto, Valenta, Rudolf, Akdis, Mübecell, Matricardi, Paolo M, Spertini, François, Khaltaev, Nicolai, Michel, Jean-Pierre, Nicod, Larent, Schmid-Grendelmeier, Peter, Idzko, Marco, Hamelmann, Eckard, Jakob, Thilo, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Jensen-Jarolim, Erika, Korn, Stephanie, Hentges, Francois, Schwarze, Jürgen, O Mahony, Liam, Knol, Edward F, Del Giacco, Stefano, Chivato Pérez, Tomás, Bousquet, Jean, Bedbrook, Anna, Zuberbier, Torsten, Akdis, Cezmi, Jutel, Marek, CTI, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Klimek, Ludger, Pfaar, Oliver, Worm, Margitta, Eiwegger, Thomas, Hagemann, Jan, Ollert, Markus, Untersmayr, Eva, Hoffmann-Sommergruber, Karin, Vultaggio, Alessandra, Agache, Ioana, Bavbek, Sevim, Bossios, Apostolos, Casper, Ingrid, Chan, Susan, Chatzipetrou, Alexia, Vogelberg, Christian, Firinu, Davide, Kauppi, Paula, Kolios, Antonios, Kothari, Akash, Matucci, Andrea, Palomares, Oscar, Szépfalusi, Zsolt, Pohl, Wolfgang, Hötzenecker, Wolfram, Rosenkranz, Alexander R, Bergmann, Karl-Christian, Bieber, Thomas, Buhl, Roland, Buters, Jeroen, Darsow, Ulf, Keil, Thomas, Kleine-Tebbe, Jörg, Lau, Susanne, Maurer, Marcus, Merk, Hans, Mösges, Ralph, Saloga, Joachim, Staubach, Petra, Jappe, Uta, Rabe, Klaus F, Rabe, Uta, Vogelmeier, Claus, Biedermann, Tilo, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Freudelsperger, Laura, Mülleneisen, Norbert, Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Tomazic, Peter-Valentin, Aberer, Werner, Fink-Wagner, Antje-Henriette, Horak, Fritz, Wöhrl, Stefan, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Roller-Wirnsberger, Regina, Spranger, Otto, Valenta, Rudolf, Akdis, Mübecell, Matricardi, Paolo M, Spertini, François, Khaltaev, Nicolai, Michel, Jean-Pierre, Nicod, Larent, Schmid-Grendelmeier, Peter, Idzko, Marco, Hamelmann, Eckard, Jakob, Thilo, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Jensen-Jarolim, Erika, Korn, Stephanie, Hentges, Francois, Schwarze, Jürgen, O Mahony, Liam, Knol, Edward F, Del Giacco, Stefano, Chivato Pérez, Tomás, Bousquet, Jean, Bedbrook, Anna, Zuberbier, Torsten, Akdis, Cezmi, and Jutel, Marek
Published: 2020

44. Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019
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45. Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019
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46. Next-generation ARIA care pathways for rhinitis and asthma:a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, De Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, Damato, Gennaro, Da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioǧlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, O'Hourihane, John B., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae Sim, Pépin, Jean Louis, Pereira, Ana Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Van Der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T.T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, De Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, Damato, Gennaro, Da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioǧlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria Antonieta, Hajjam, Jawad, O'Hourihane, John B., Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae Sim, Pépin, Jean Louis, Pereira, Ana Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, Van Der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhi-nitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019

47. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted patient activation, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019

48. Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019
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49. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted patient activation, (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019

50. Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases

Author: Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, Bousquet, J. Jean, Schunemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenco, Olga M., Menditto, Enrica, Mullo, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhan, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bia, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D'Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioglu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, Gonzalez Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzman, Maria-Antonieta, Hajjam, Jawad, Hourihane, John O'B, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Carlsen, Karin C. Lodrup, Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, Keenoy, Esteban De Manuel, Marshall, Gallen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melen, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinezl, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Moesges, Raft, Munter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonne, O'Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schoell, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pepin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Soderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimaki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Sole, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Ulrik, Charlotte Suppli, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter, V, Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frederic, Vieg, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stephane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., and Zidarn, Mihaela
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019
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