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1. Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on Acute Admissions at the Emergency and Cardiology Departments Across Europe

Author

Sokolski, M, Gajewski, P, Zymliński, R, Biegus, J, Berg, J, Bor, W, Braunschweig, F, Caldeira, D, Cuculi, F, D'Elia, E, Edes, I, Garus, M, Greenwood, J, Halfwerk, F, Hindricks, G, Knuuti, J, Kristensen, S, Landmesser, U, Lund, L, Lyon, A, Mebazaa, A, Merkely, B, Nawrocka-Millward, S, Pinto, F, Ruschitzka, F, Semedo, E, Senni, M, Sepehri Shamloo, A, Sorensen, J, Stengaard, C, Thiele, H, Toggweiler, S, Tukiendorf, A, Verhorst, P, Wright, D, Zamorano, P, Zuber, M, Narula, J, Bax, J, Ponikowski, P, Sokolski M, Gajewski P, Zymliński R, Biegus J, Berg JMT, Bor W, Braunschweig F, Caldeira D, Cuculi F, D'Elia E, Edes IF, Garus M, Greenwood JP, Halfwerk FR, Hindricks G, Knuuti J, Kristensen SD, Landmesser U, Lund LH, Lyon A, Mebazaa A, Merkely B, Nawrocka-Millward S, Pinto FJ, Ruschitzka F, Semedo E, Senni M, Sepehri Shamloo A, Sorensen J, Stengaard C, Thiele H, Toggweiler S, Tukiendorf A, Verhorst PM, Wright DJ, Zamorano P, Zuber M, Narula J, Bax JJ, Ponikowski P, Sokolski, M, Gajewski, P, Zymliński, R, Biegus, J, Berg, J, Bor, W, Braunschweig, F, Caldeira, D, Cuculi, F, D'Elia, E, Edes, I, Garus, M, Greenwood, J, Halfwerk, F, Hindricks, G, Knuuti, J, Kristensen, S, Landmesser, U, Lund, L, Lyon, A, Mebazaa, A, Merkely, B, Nawrocka-Millward, S, Pinto, F, Ruschitzka, F, Semedo, E, Senni, M, Sepehri Shamloo, A, Sorensen, J, Stengaard, C, Thiele, H, Toggweiler, S, Tukiendorf, A, Verhorst, P, Wright, D, Zamorano, P, Zuber, M, Narula, J, Bax, J, Ponikowski, P, Sokolski M, Gajewski P, Zymliński R, Biegus J, Berg JMT, Bor W, Braunschweig F, Caldeira D, Cuculi F, D'Elia E, Edes IF, Garus M, Greenwood JP, Halfwerk FR, Hindricks G, Knuuti J, Kristensen SD, Landmesser U, Lund LH, Lyon A, Mebazaa A, Merkely B, Nawrocka-Millward S, Pinto FJ, Ruschitzka F, Semedo E, Senni M, Sepehri Shamloo A, Sorensen J, Stengaard C, Thiele H, Toggweiler S, Tukiendorf A, Verhorst PM, Wright DJ, Zamorano P, Zuber M, Narula J, Bax JJ, and Ponikowski P

Abstract

Purpose: We evaluated whether the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) pandemic was associated with changes in the pattern of acute cardiovascular admissions across European centers. Methods: We set-up a multicenter, multinational, pan-European observational registry in 15 centers from 12 countries. All consecutive acute admissions to emergency departments and cardiology departments throughout a 1-month period during the COVID-19 outbreak were compared with an equivalent 1-month period in 2019. The acute admissions to cardiology departments were classified into 5 major categories: acute coronary syndrome, acute heart failure, arrhythmia, pulmonary embolism, and other. Results: Data from 54,331 patients were collected and analyzed. Nine centers provided data on acute admissions to emergency departments comprising 50,384 patients: 20,226 in 2020 compared with 30,158 in 2019 (incidence rate ratio [IRR] with 95% confidence interval [95%CI]: 0.66 [0.58-0.76]). The risk of death at the emergency departments was higher in 2020 compared to 2019 (odds ratio [OR] with 95% CI: 4.1 [3.0-5.8], P < 0.0001). All 15 centers provided data on acute cardiology departments admissions: 3007 patients in 2020 and 4452 in 2019; IRR (95% CI): 0.68 (0.64-0.71). In 2020, there were fewer admissions with IRR (95% CI): acute coronary syndrome: 0.68 (0.63-0.73); acute heart failure: 0.65 (0.58-0.74); arrhythmia: 0.66 (0.60-0.72); and other: 0.68(0.62-0.76). We found a relatively higher percentage of pulmonary embolism admissions in 2020: odds ratio (95% CI): 1.5 (1.1-2.1), P = 0.02. Among patients with acute coronary syndrome, there were fewer admissions with unstable angina: 0.79 (0.66-0.94); non-ST segment elevation myocardial infarction: 0.56 (0.50-0.64); and ST-segment elevation myocardial infarction: 0.78 (0.68-0.89). Conclusion: In the European centers during the COVID-19 outbreak, there were fewer acute cardiovascular admissions. Also, fewer patients were admitt

Published
2021

2. Rationale and design of the EU‐CERT‐ICD prospective study:comparative effectiveness of prophylactic ICD implantation

Author

Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), Mansch, R. (R.), Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), and Mansch, R. (R.)

Abstract

Aims: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results: The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non‐randomized control group). The primary endpoint is all‐cause mortality; the co‐primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost‐effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12‐lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions: The EU‐CERT‐ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

Published
2019

3. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., Tolosana, J.M., Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., and Tolosana, J.M.

Abstract

Contains fulltext : 239015.pdf (Publisher’s version ) (Closed access)

Published
2021

4. EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS)

Author

Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., Martins Oliveira, M., Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., and Martins Oliveira, M.

Abstract

Contains fulltext : 238765.pdf (Publisher’s version ) (Closed access), With the global increase in device implantations, there is a growing need to train physicians to implant pacemakers and implantable cardioverter-defibrillators. Although there are international recommendations for device indications and programming, there is no consensus to date regarding implantation technique. This document is founded on a systematic literature search and review, and on consensus from an international task force. It aims to fill the gap by setting standards for device implantation.

Published
2021

5. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., Tolosana, J.M., Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., and Tolosana, J.M.

Abstract

Contains fulltext : 239015.pdf (Publisher’s version ) (Closed access)

Published
2021

6. EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS)

Author

Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., Martins Oliveira, M., Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., and Martins Oliveira, M.

Abstract

Contains fulltext : 238765.pdf (Publisher’s version ) (Closed access), With the global increase in device implantations, there is a growing need to train physicians to implant pacemakers and implantable cardioverter-defibrillators. Although there are international recommendations for device indications and programming, there is no consensus to date regarding implantation technique. This document is founded on a systematic literature search and review, and on consensus from an international task force. It aims to fill the gap by setting standards for device implantation.

Published
2021

7. EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS)

Author

Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., Martins Oliveira, M., Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A., Deharo, J.C., Glikson, M., Israel, C., Lau, C.P., Leclercq, C., Love, C.J., Nielsen, J.C., Vernooy, K., Dagres, N., Boveda, S., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G.H., Gleva, M., Defaye, P., Zanon, F., Lopez-Cabanillas, N., Guerra, J.M., Vassilikos, V.P., and Martins Oliveira, M.

Abstract

Contains fulltext : 238765.pdf (Publisher’s version ) (Closed access), With the global increase in device implantations, there is a growing need to train physicians to implant pacemakers and implantable cardioverter-defibrillators. Although there are international recommendations for device indications and programming, there is no consensus to date regarding implantation technique. This document is founded on a systematic literature search and review, and on consensus from an international task force. It aims to fill the gap by setting standards for device implantation.

Published
2021

8. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., Tolosana, J.M., Glikson, M., Nielsen, J.C., Kronborg, M.B., Michowitz, Y., Auricchio, A., Barbash, I.M., Barrabés, J.A., Boriani, G., Braunschweig, F., Brignole, M., Burri, H., Coats, A.J.S., Deharo, J.C., Delgado, V., Diller, G.P., Israel, C.W., Keren, A., Knops, R.E., Kotecha, D., Leclercq, C., Merkely, B., Starck, C., Vernooy, K., Thylén, I., and Tolosana, J.M.

Abstract

Contains fulltext : 239015.pdf (Publisher’s version ) (Closed access)

Published
2021

9. Appropriate shocks and mortality in patients with versus without diabetes with prophylactic implantable cardioverter defibrillators

Author

Junttila, M. J. (M. Juhani), Pelli, A. (Ari), Kenttä, T. V. (Tuomas V.), Friede, T. (Tim), Willems, R. (Rik), Bergau, L. (Leonard), Malik, M. (Marek), Vandenberk, B. (Bert), Vos, M. A. (Marc A.), Schmidt, G. (Georg), Merkely, B. (Bela), Lubinski, A. (Andrzej), Svetlosak, M. (Martin), Braunschweig, F. (Frieder), Harden, M. (Markus), Zabel, M. (Markus), Huikuri, H. V. (Heikki V.), Sticherling, C. (Christian), Junttila, M. J. (M. Juhani), Pelli, A. (Ari), Kenttä, T. V. (Tuomas V.), Friede, T. (Tim), Willems, R. (Rik), Bergau, L. (Leonard), Malik, M. (Marek), Vandenberk, B. (Bert), Vos, M. A. (Marc A.), Schmidt, G. (Georg), Merkely, B. (Bela), Lubinski, A. (Andrzej), Svetlosak, M. (Martin), Braunschweig, F. (Frieder), Harden, M. (Markus), Zabel, M. (Markus), Huikuri, H. V. (Heikki V.), and Sticherling, C. (Christian)

Abstract

Objective: Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to sudden death in diabetes are not well known. We compared the incidence of appropriate shocks and mortality in patients with versus without diabetes with a prophylactic implantable cardioverter defibrillator (ICD) included in the retrospective EU-CERT-ICD registry. Research design and methods and results: A total of 3,535 patients from 12 European EU-CERT-ICD centers with a mean age of 63.7 ± 11.2 years (82% males) at the time of ICD implantation were included in the analysis. A total of 995 patients (28%) had a history of diabetes. All patients had an ICD implanted for primary SCD prevention. End points were appropriate shock and all-cause mortality. Mean follow-up time was 3.2 ± 2.3 years. Diabetes was associated with a lower risk of appropriate shocks (adjusted hazard ratio [HR] 0.77 [95% CI 0.62–0.96], P = 0.02). However, patients with diabetes had significantly higher mortality (adjusted HR 1.30 [95% CI 1.11–1.53], P = 0.001). Conclusions: All-cause mortality is higher in patients with diabetes than in patients without diabetes with primary prophylactic ICDs. Subsequently, patients with diabetes have a lower incidence of appropriate ICD shocks, indicating that the excess mortality might not be caused primarily by ventricular tachyarrhythmias. These findings suggest a limitation of the potential of prophylactic ICD therapy to improve survival in patients with diabetes with impaired left ventricular function.

Published
2020

10. Sex differences in outcomes of primary prevention implantable cardioverter-defibrillator therapy:combined registry data from eleven European countries

Author

Sticherling, C. (Christian), Arendacka, B. (Barbora), Svendsen, J. H. (Jesper Hastrup), Wijers, S. (Sofieke), Friede, T. (Tim), Stockinger, J. (Jochem), Dommasch, M. (Michael), Merkely, B. (Bela), Willems, R. (Rik), Lubinski, A. (Andrzej), Scharfe, M. (Michael), Braunschweig, F. (Frieder), Svetlosak, M. (Martin), Zürn, C. S. (Christine S.), Huikuri, H. (Heikki), Flevari, P. (Panagiota), Lund-Andersen, C. (Caspar), Schaer, B. A. (Beat A.), Tuinenburg, A. E. (Anton E.), Bergau, L. (Leonard), Schmidt, G. (Georg), Szeplaki, G. (Gabor), Vandenberk, B. (Bert), Kowalczyk, E. (Emilia), Eick, C. (Christian), Junttila, J. (Juhani), Conen, D. (David), Zabel, M. (Markus), Sticherling, C. (Christian), Arendacka, B. (Barbora), Svendsen, J. H. (Jesper Hastrup), Wijers, S. (Sofieke), Friede, T. (Tim), Stockinger, J. (Jochem), Dommasch, M. (Michael), Merkely, B. (Bela), Willems, R. (Rik), Lubinski, A. (Andrzej), Scharfe, M. (Michael), Braunschweig, F. (Frieder), Svetlosak, M. (Martin), Zürn, C. S. (Christine S.), Huikuri, H. (Heikki), Flevari, P. (Panagiota), Lund-Andersen, C. (Caspar), Schaer, B. A. (Beat A.), Tuinenburg, A. E. (Anton E.), Bergau, L. (Leonard), Schmidt, G. (Georg), Szeplaki, G. (Gabor), Vandenberk, B. (Bert), Kowalczyk, E. (Emilia), Eick, C. (Christian), Junttila, J. (Juhani), Conen, D. (David), and Zabel, M. (Markus)

Abstract

Aims: Therapy with an implantable cardioverter defibrillator (ICD) is established for the prevention of sudden cardiac death (SCD) in high risk patients. We aimed to determine the effectiveness of primary prevention ICD therapy by analysing registry data from 14 centres in 11 European countries compiled between 2002 and 2014, with emphasis on outcomes in women who have been underrepresented in all trials. Methods and results: Retrospective data of 14 local registries of primary prevention ICD implantations between 2002 and 2014 were compiled in a central database. Predefined primary outcome measures were overall mortality and first appropriate and first inappropriate shocks. A multivariable model enforcing a common hazard ratio for sex category across the centres, but allowing for centre-specific baseline hazards and centre specific effects of other covariates, was adjusted for age, the presence of ischaemic cardiomyopathy or a CRT-D, and left ventricular ejection fraction ≤25%. Of the 5033 patients, 957 (19%) were women. During a median follow-up of 33 months (IQR 16–55 months) 129 women (13%) and 807 men (20%) died (HR 0.65; 95% CI: [0.53, 0.79], P-value < 0.0001). An appropriate ICD shock occurred in 66 women (8%) and 514 men (14%; HR 0.61; 95% CI: 0.47–0.79; P = 0.0002). Conclusion: Our retrospective analysis of 14 local registries in 11 European countries demonstrates that fewer women than men undergo ICD implantation for primary prevention. After multivariate adjustment, women have a significantly lower mortality and receive fewer appropriate ICD shocks.

Published
2018

11. Heart rate and dyssynchrony in patients with cardiac resynchronization therapy : a pilot study

Author

Naar, J., Mortensen, L., Winter, Reidar, Johnson, Jonas, Shahgaldi, K., Manouras, A., Braunschweig, F., Ståhlberg, M., Naar, J., Mortensen, L., Winter, Reidar, Johnson, Jonas, Shahgaldi, K., Manouras, A., Braunschweig, F., and Ståhlberg, M.

Abstract

Objectives: The objective of this pilot study was to describe the impact of paced heart rate on left ventricular (LV) mechanical dyssynchrony in synchronous compared to dyssynchronous pacing modes in patients with heart failure. Methods: Echocardiography was performed in 14 cardiac resynchronization therapy (CRT) patients at paced heart rates of 70 and 90 bpm in synchronous- (CRT), and dyssynchronous (atrial pacing + wide QRS activation) pacing modes. LV dyssynchrony was quantified using the 12-segment standard deviation model (Ts-SD) derived from Tissue Doppler Imaging. In addition, cardiac cycle intervals were assessed using cardiac state diagrams and stroke volume (SV) and filling pressure were estimated. Results: Ts-SD decreased significantly with CRT at 90 bpm (25 ± 12 ms) compared to 70 bpm (35 ± 15 ms, p =.01), but remained unchanged with atrial pacing at different paced heart rates (p =.96). The paced heart rate dependent reduction in Ts-SD was consistent when Ts-SD was indexed to average Ts and systolic time interval. Cardiac state diagram derived analysis of cardiac cycle intervals demonstrated a significant reduction of the pre-ejection interval and an increase in diastole with CRT compared to atrial pacing. SV was maintained at the higher paced heart rate with CRT pacing but decreased with atrial pacing. Discussion: Due to the small sample size in this pilot study general and firm conclusions are difficult to render. However, the data suggest that pacing at higher heart rates acutely reduces remaining LV dyssynchrony during CRT, but not during atrial pacing with dyssynchronous ventricular activation. These results need confirmation in a larger patient cohort., QC 20170608

Published
2017
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22. Den allzufrühen Verlust ihres theuren und hochverdienten Lehrers, des ... Herrn Johann Christoph Wurtzlers, ... der Hohen Stifts-Schule zu Halberstadt Rectors, Welcher den 29. Octob. 1758. durch einen unerwarteten Tod ihnen entrissen wurde, beklagten in nachstehen Zeilen die Schüler der ersten Ordnung, D. Dreyer. F. J. Braunschweig. C. F. Treuding, J. A. Kuhlmann. A. J. G. Thilo ...

Author

Braunschweig, F. J., Treuding, C. F., Kuhlmann, J. A., Thilo, A. J. G., Dreyer, D., Braunschweig, F. J., Treuding, C. F., Kuhlmann, J. A., Thilo, A. J. G., and Dreyer, D.

Abstract

Das Trauergedicht wurde insgesamt von 32 Schülern unterzeichnet, Autopsie nach Ex. der ULB Sachsen-Anhalt, Vorlageform des Erscheinungsvermerks: Halberstadt, gedruckt in Friderichs Erben Buchdruckerey.

23. Den allzufrühen Verlust ihres theuren und hochverdienten Lehrers, des ... Herrn Johann Christoph Wurtzlers, ... der Hohen Stifts-Schule zu Halberstadt Rectors, Welcher den 29. Octob. 1758. durch einen unerwarteten Tod ihnen entrissen wurde, beklagten in nachstehen Zeilen die Schüler der ersten Ordnung, D. Dreyer. F. J. Braunschweig. C. F. Treuding, J. A. Kuhlmann. A. J. G. Thilo ...

Author

Braunschweig, F. J., Treuding, C. F., Kuhlmann, J. A., Thilo, A. J. G., Dreyer, D., Braunschweig, F. J., Treuding, C. F., Kuhlmann, J. A., Thilo, A. J. G., and Dreyer, D.

Abstract

Das Trauergedicht wurde insgesamt von 32 Schülern unterzeichnet, Autopsie nach Ex. der ULB Sachsen-Anhalt, Vorlageform des Erscheinungsvermerks: Halberstadt, gedruckt in Friderichs Erben Buchdruckerey.

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