1. Preimplantation factor modulates oligodendrocytes by H19-induced demethylation of NCOR2
- Author
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Spinelli, M, Boucard, C, Ornaghi, S, Schoeberlein, A, Irene, K, Coman, D, Hyder, F, Zhang, L, Haesler, V, Bordey, A, Barnea, E, Paidas, M, Surbek, D, Mueller, M, Spinelli M., Boucard C., Ornaghi S., Schoeberlein A., Irene K., Coman D., Hyder F., Zhang L., Haesler V., Bordey A., Barnea E., Paidas M., Surbek D., Mueller M., Spinelli, M, Boucard, C, Ornaghi, S, Schoeberlein, A, Irene, K, Coman, D, Hyder, F, Zhang, L, Haesler, V, Bordey, A, Barnea, E, Paidas, M, Surbek, D, Mueller, M, Spinelli M., Boucard C., Ornaghi S., Schoeberlein A., Irene K., Coman D., Hyder F., Zhang L., Haesler V., Bordey A., Barnea E., Paidas M., Surbek D., and Mueller M.
- Abstract
Failed or altered gliogenesis is a major characteristic of diffuse white matter injury in survivors of premature birth. The developmentally regulated long noncoding RNA (lncRNA) H19 inhibits S-adenosylhomocysteine hydrolase (SAHH) and contributes to methylation of diverse cellular components, such as DNA, RNA, proteins, lipids, and neurotransmitters. We showed that the pregnancy-derived synthetic PreImplantation Factor (sPIF) induces expression of the nuclear receptor corepressor 2 (NCOR2) via H19/SAHH-mediated DNA demethylation. In turn, NCOR2 affects oligodendrocyte differentiation markers. Accordingly, after hypoxic-ischemic brain injury in rodents, myelin protection and oligodendrocytes’ fate are in part modulated by sPIF and H19. Our results revealed an unexpected mechanism of the H19/SAHH axis underlying myelin preservation during brain recovery and its use in treating neurodegenerative diseases can be envisioned.
- Published
- 2021