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1. Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020

Author: Aguiar de Sousa, Diana, Wilkie, Arlene, Norrving, Bo, Macey, Chris, Bassetti, Claudio, Tiu, Cristina, Roth, Greg, Lunde, Grethe, Christensen, Hanne, Fiehler, Jens, Pezzella, Francesca Romana, Dichgans, Martin, Roaldsen, Melinda B., Kelly, Peter, Mikulik, Robert, Sacco, Simona, Caso, Valeria, Fischer, Urs, Basha, Entela, Yeghiazaryan, Nune, Kiechl, Stefan, Shiraliyeva, Rana, Vanacker, Peter, Bender, Marija, Emilov Tsalta-Mladenov, Mihael, Budincevic, Hrvoje, Tomek, Ales, Kaponides, Georgios, Klingenberg Iversen, Helle, Faiss, Jürgen, Kõrv, Janika, Sairanen, Tiina, Igor, Sibon, Tsiskaridze, Alexander, Ntaios, George, Tsivgoulis, Georgios, Szapary, Laszlo, Logi Thorarinsson, Bjorn, Harbison, Joe, Bornstein, Natan M., Toni, Danilo, Fisnik, Jashari, Karbozova, Kunduz, Miglane, Evija, Dalius, Jatužis, Droste, Dirk, Mallia, Maria, Jevto, Erakovic, Arsovska, Anita, Fromm, Annette, Aguiar de Sousa, Diana, Wilkie, Arlene, Norrving, Bo, Macey, Chris, Bassetti, Claudio, Tiu, Cristina, Roth, Greg, Lunde, Grethe, Christensen, Hanne, Fiehler, Jens, Pezzella, Francesca Romana, Dichgans, Martin, Roaldsen, Melinda B., Kelly, Peter, Mikulik, Robert, Sacco, Simona, Caso, Valeria, Fischer, Urs, Basha, Entela, Yeghiazaryan, Nune, Kiechl, Stefan, Shiraliyeva, Rana, Vanacker, Peter, Bender, Marija, Emilov Tsalta-Mladenov, Mihael, Budincevic, Hrvoje, Tomek, Ales, Kaponides, Georgios, Klingenberg Iversen, Helle, Faiss, Jürgen, Kõrv, Janika, Sairanen, Tiina, Igor, Sibon, Tsiskaridze, Alexander, Ntaios, George, Tsivgoulis, Georgios, Szapary, Laszlo, Logi Thorarinsson, Bjorn, Harbison, Joe, Bornstein, Natan M., Toni, Danilo, Fisnik, Jashari, Karbozova, Kunduz, Miglane, Evija, Dalius, Jatužis, Droste, Dirk, Mallia, Maria, Jevto, Erakovic, Arsovska, Anita, and Fromm, Annette
Abstract: Introduction: We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) and endovascular treatment (EVT) in the European region in 2019 and 2020. Patients and methods: We compared national data per number of inhabitants and per 100 annual incident first-ever ischaemic strokes (AIIS) in 46 countries. Population estimates and ischaemic stroke incidence were based on United Nations data and the Global Burden of Disease Report 2019, respectively. Results: The estimated mean number of acute SUs in 2019 was 3.68 (95% CI: 2.90–4.45) per one million inhabitants (MIH) with 7/44 countries having less than one SU per one MIH. The estimated mean annual number of IVTs was 21.03 (95% CI: 15.63–26.43) per 100,000 and 17.14% (95% CI: 12.98–21.30) of the AIIS in 2019, with highest country rates at 79.19 and 52.66%, respectively, and 15 countries delivering less than 10 IVT per 100,000. The estimated mean annual number of EVTs in 2019 was 7.87 (95% CI: 5.96–9.77) per 100,000 and 6.91% (95% CI: 5.15–8.67) of AIIS, with 11 countries delivering less than 1.5 EVT per 100,000. Rates of SUs, IVT and EVT were stable in 2020. There was an increase in mean rates of SUs, IVT and EVT compared to similar data from 2016. Conclusion: Although there was an increase in reperfusion treatment rates in many countries between 2016 and 2019, this was halted in 2020. There are persistent major inequalities in acute stroke treatment in the European region. Tailored strategies directed to the most vulnerable regions should be prioritised.
Published: 2023

2. Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020

Author: Aguiar de Sousa, Diana, Wilkie, Arlene, Norrving, Bo, Macey, Chris, Bassetti, Claudio, Tiu, Cristina, Roth, Greg, Lunde, Grethe, Christensen, Hanne, Fiehler, Jens, Pezzella, Francesca Romana, Dichgans, Martin, Roaldsen, Melinda B., Kelly, Peter, Mikulik, Robert, Sacco, Simona, Caso, Valeria, Fischer, Urs, Basha, Entela, Yeghiazaryan, Nune, Kiechl, Stefan, Shiraliyeva, Rana, Vanacker, Peter, Bender, Marija, Emilov Tsalta-Mladenov, Mihael, Budincevic, Hrvoje, Tomek, Ales, Kaponides, Georgios, Klingenberg Iversen, Helle, Faiss, Jürgen, Kõrv, Janika, Sairanen, Tiina, Igor, Sibon, Tsiskaridze, Alexander, Ntaios, George, Tsivgoulis, Georgios, Szapary, Laszlo, Logi Thorarinsson, Bjorn, Harbison, Joe, Bornstein, Natan M., Toni, Danilo, Fisnik, Jashari, Karbozova, Kunduz, Miglane, Evija, Dalius, Jatužis, Droste, Dirk, Mallia, Maria, Jevto, Erakovic, Arsovska, Anita, Fromm, Annette, Aguiar de Sousa, Diana, Wilkie, Arlene, Norrving, Bo, Macey, Chris, Bassetti, Claudio, Tiu, Cristina, Roth, Greg, Lunde, Grethe, Christensen, Hanne, Fiehler, Jens, Pezzella, Francesca Romana, Dichgans, Martin, Roaldsen, Melinda B., Kelly, Peter, Mikulik, Robert, Sacco, Simona, Caso, Valeria, Fischer, Urs, Basha, Entela, Yeghiazaryan, Nune, Kiechl, Stefan, Shiraliyeva, Rana, Vanacker, Peter, Bender, Marija, Emilov Tsalta-Mladenov, Mihael, Budincevic, Hrvoje, Tomek, Ales, Kaponides, Georgios, Klingenberg Iversen, Helle, Faiss, Jürgen, Kõrv, Janika, Sairanen, Tiina, Igor, Sibon, Tsiskaridze, Alexander, Ntaios, George, Tsivgoulis, Georgios, Szapary, Laszlo, Logi Thorarinsson, Bjorn, Harbison, Joe, Bornstein, Natan M., Toni, Danilo, Fisnik, Jashari, Karbozova, Kunduz, Miglane, Evija, Dalius, Jatužis, Droste, Dirk, Mallia, Maria, Jevto, Erakovic, Arsovska, Anita, and Fromm, Annette
Abstract: Introduction: We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) and endovascular treatment (EVT) in the European region in 2019 and 2020. Patients and methods: We compared national data per number of inhabitants and per 100 annual incident first-ever ischaemic strokes (AIIS) in 46 countries. Population estimates and ischaemic stroke incidence were based on United Nations data and the Global Burden of Disease Report 2019, respectively. Results: The estimated mean number of acute SUs in 2019 was 3.68 (95% CI: 2.90–4.45) per one million inhabitants (MIH) with 7/44 countries having less than one SU per one MIH. The estimated mean annual number of IVTs was 21.03 (95% CI: 15.63–26.43) per 100,000 and 17.14% (95% CI: 12.98–21.30) of the AIIS in 2019, with highest country rates at 79.19 and 52.66%, respectively, and 15 countries delivering less than 10 IVT per 100,000. The estimated mean annual number of EVTs in 2019 was 7.87 (95% CI: 5.96–9.77) per 100,000 and 6.91% (95% CI: 5.15–8.67) of AIIS, with 11 countries delivering less than 1.5 EVT per 100,000. Rates of SUs, IVT and EVT were stable in 2020. There was an increase in mean rates of SUs, IVT and EVT compared to similar data from 2016. Conclusion: Although there was an increase in reperfusion treatment rates in many countries between 2016 and 2019, this was halted in 2020. There are persistent major inequalities in acute stroke treatment in the European region. Tailored strategies directed to the most vulnerable regions should be prioritised.
Published: 2023

3. Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) – study protocol for a randomised controlled trial

Author: Kelly, Peter, Weimar, Christian, Lemmens, Robin, Murphy, Sean, Purroy, Francisco, Arsovska, Anita, Bornstein, Natan M., Czlonkowska, Anna, Fischer, Urs, Fonseca, Ana Catarina, Forbes, John, Hill, Michael D., Jatuzis, Dalius, Kõrv, Janika, Kruuse, Christina, Mikulik, Robert, J Nederkoorn, Paul, O’Donnell, Martin, Sandercock, Peter, Tanne, David, Tsivgoulis, Georgios, Walsh, Cathal, Williams, David, Zedde, Marialuisa, Price, Christopher I., Kelly, Peter, Weimar, Christian, Lemmens, Robin, Murphy, Sean, Purroy, Francisco, Arsovska, Anita, Bornstein, Natan M., Czlonkowska, Anna, Fischer, Urs, Fonseca, Ana Catarina, Forbes, John, Hill, Michael D., Jatuzis, Dalius, Kõrv, Janika, Kruuse, Christina, Mikulik, Robert, J Nederkoorn, Paul, O’Donnell, Martin, Sandercock, Peter, Tanne, David, Tsivgoulis, Georgios, Walsh, Cathal, Williams, David, Zedde, Marialuisa, and Price, Christopher I.
Abstract: Background: Inflammation contributes to unstable atherosclerotic plaque and stroke. In randomised trials in patients with coronary disease, canukinumab (an interleukin-1B antagonist) and colchicine (a tubulin inhibitor with pleiotropic anti-inflammatory effects) reduced recurrent vascular events. Hypothesis: Anti-inflammatory therapy with low-dose colchicine plus usual care will reduce recurrent vascular events in patients with non-severe, non-cardioembolic stroke and TIA compared with usual care alone. Design: CONVINCE is a multi-centre international (in 17 countries) Prospective, Randomised Open-label, Blinded-Endpoint assessment (PROBE) controlled Phase 3 clinical trial in 3154 participants. The intervention is colchicine 0.5 mg/day and usual care versus usual care alone (antiplatelet, lipid-lowering, antihypertensive treatment, lifestyle advice). Included patients are at least 40 years, with non-severe ischaemic stroke (modified Rankin score ≤3) or high-risk TIA (ABCD2 > 3, or positive DWI, or cranio-cervical artery stenosis) within 72 hours-28 days of randomisation, with qualifying stroke/TIA most likely caused by large artery stenosis, lacunar disease, or cryptogenic embolism. Exclusions are stroke/TIA caused by cardio-embolism or other defined cause (e.g. dissection), contra-indication to colchicine (including potential drug interactions), or incapacity for participation in a clinical trial. The anticipated median follow-up will be 36 months. The primary analysis will be by intention-to-treat. Outcome: The primary outcome is time to first recurrent ischaemic stroke, myocardial infarction, cardiac arrest, or hospitalisation with unstable angina (non-fatal or fatal). Summary: CONVINCE will provide high-quality randomised data on the efficacy and safety of anti-inflammatory therapy with colchicine for secondary prevention after stroke. Schedule: First-patient first-visit was December 2016. Recruitment to complete in 2021, follow-up to complete in 2023.
Published: 2021

4. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013 : quantifying the epidemiological transition

Author: Murray, Christopher J L, Barber, Ryan M, Foreman, Kyle J, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Jerry P, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M, Achoki, Tom, Ackerman, Ilana N, Ademi, Zanfina, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, François, Allebeck, Peter, Almazroa, Mohammad A, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ameh, Emmanuel A, Amini, Heresh, Ammar, Walid, Anderson, H Ross, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Avila, Marco A, Awuah, Baffour, Bachman, Victoria F, Badawi, Alaa, Bahit, Maria C, Balakrishnan, Kalpana, Banerjee, Amitava, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Bernabé, Eduardo, Bertozzi-Villa, Amelia, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bienhoff, Kelly, Bikbov, Boris, Biryukov, Stan, Blore, Jed D, Blosser, Christopher D, Blyth, Fiona M, Bohensky, Megan A, Bolliger, Ian W, Başara, Berrak Bora, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R A, Boyers, Lindsay N, Brainin, Michael, Brayne, Carol E, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Briggs, Adam D, Brooks, Peter M, Brown, Jonathan C, Brugha, Traolach S, Buchbinder, Rachelle, Buckle, Geoffrey C, Budke, Christine M, Bulchis, Anne, Bulloch, Andrew G, Campos-Nonato, Ismael R, Carabin, Hélène, Carapetis, Jonathan R, Cárdenas, Rosario, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christensen, Hanne, Christophi, Costas A, Cirillo, Massimo, Coates, Matthew M, Coffeng, Luc E, Coggeshall, Megan S, Colistro, Valentina, Colquhoun, Samantha M, Cooke, Graham S, Cooper, Cyrus, Cooper, Leslie T, Coppola, Luis M, Cortinovis, Monica, Criqui, Michael H, Crump, John A, Cuevas-Nasu, Lucia, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dansereau, Emily, Dargan, Paul I, Davey, Gail, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, De Leo, Diego, Degenhardt, Louisa, Del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Jarlais, Don C Des, Dessalegn, Muluken, Dharmaratne, Samath D, Dherani, Mukesh K, Diaz-Torné, Cesar, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Duber, Herbert C, Ebel, Beth E, Edmond, Karen M, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Estep, Kara, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F, Feigin, Valery L, Felson, David T, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Ferrari, Alize J, Fitzmaurice, Christina, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Forouzanfar, Mohammad H, Fowkes, F Gerry R, Paleo, Urbano Fra, Franklin, Richard C, Fürst, Thomas, Gabbe, Belinda, Gaffikin, Lynne, Gankpé, Fortuné G, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Peter, Gibney, Katherine B, Giroud, Maurice, Giussani, Giorgia, Dantes, Hector Gomez, Gona, Philimon, González-Medina, Diego, Gosselin, Richard A, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Graetz, Nicholas, Gugnani, Harish C, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Haagsma, Juanita, Hafezi-Nejad, Nima, Hagan, Holly, Halasa, Yara A, Hamadeh, Randah R, Hamavid, Hannah, Hammami, Mouhanad, Hancock, Jamie, Hankey, Graeme J, Hansen, Gillian M, Hao, Yuantao, Harb, Hilda L, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I, Hay, Roderick J, Heredia-Pi, Ileana B, Heuton, Kyle R, Heydarpour, Pouria, Higashi, Hideki, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hosgood, H Dean, Hossain, Mazeda, Hotez, Peter J, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Huang, Cheng, Huang, John J, Husseini, Abdullatif, Huynh, Chantal, Iannarone, Marissa L, Iburg, Kim M, Innos, Kaire, Inoue, Manami, Islami, Farhad, Jacobsen, Kathryn H, Jarvis, Deborah L, Jassal, Simerjot K, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Karch, André, Karema, Corine K, Karimkhani, Chante, Karthikeyan, Ganesan, Kassebaum, Nicholas J, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin A, Khan, Ejaz A, Khan, Gulfaraz, Khang, Young-Ho, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kinfu, Yohannes, Kinge, Jonas M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kosen, Soewarta, Krishnaswami, Sanjay, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G Anil, Kyu, Hmwe H, Lai, Taavi, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larsson, Anders, Lawrynowicz, Alicia E B, Leasher, Janet L, Leigh, James, Leung, Ricky, Levitz, Carly E, Li, Bin, Li, Yichong, Li, Yongmei, Lim, Stephen S, Lind, Maggie, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lofgren, Katherine T, Logroscino, Giancarlo, Looker, Katharine J, Lortet-Tieulent, Joannie, Lotufo, Paulo A, Lozano, Rafael, Lucas, Robyn M, Lunevicius, Raimundas, Lyons, Ronan A, Ma, Stefan, Macintyre, Michael F, Mackay, Mark T, Majdan, Marek, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marzan, Melvin B, Masci, Joseph R, Mashal, Mohammad T, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, Mcgill, Neil W, Mcgrath, John J, Mckee, Martin, Mclain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Meretoja, Atte, Mhimbira, Francis A, Micha, Renata, Miller, Ted R, Mills, Edward J, Mitchell, Philip B, Mock, Charles N, Ibrahim, Norlinah Mohamed, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L D, Monasta, Lorenzo, Hernandez, Julio C Montañez, Montico, Marcella, Montine, Thomas J, Mooney, Meghan D, Moore, Ami R, Moradi-Lakeh, Maziar, Moran, Andrew E, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Moyer, Madeline L, Mozaffarian, Dariush, Msemburi, William T, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murdoch, Michele E, Murray, Joseph, Murthy, Kinnari S, Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M Venkat, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ng, Marie, Ngalesoni, Frida N, Nguyen, Grant, Nisar, Muhammad I, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Ohno, Summer L, Olusanya, Bolajoko O, Opio, John Nelson, Ortblad, Katrina, Ortiz, Alberto, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Park, Jae-Hyun, Patten, Scott B, Patton, George C, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phillips, Bryan K, Phillips, David E, Piel, Frédéric B, Plass, Dietrich, Poenaru, Dan, Polinder, Suzanne, Pope, Daniel, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Pullan, Rachel L, Qato, Dima M, Quistberg, D Alex, Rafay, Anwar, Rahimi, Kazem, Rahman, Sajjad U, Raju, Murugesan, Rana, Saleem M, Razavi, Homie, Reddy, K Srinath, Refaat, Amany, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L, Richardson, Lee, Richardus, Jan Hendrik, Roberts, D Allen, Rojas-Rueda, David, Ronfani, Luca, Roth, Gregory A, Rothenbacher, Dietrich, Rothstein, David H, Rowley, Jane T, Roy, Nobhojit, Ruhago, George M, Saeedi, Mohammad Y, Saha, Sukanta, Sahraian, Mohammad Ali, Sampson, Uchechukwu K A, Sanabria, Juan R, Sandar, Logan, Santos, Itamar S, Satpathy, Maheswar, Sawhney, Monika, Scarborough, Peter, Schneider, Ione J, Schöttker, Ben, Schumacher, Austin E, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serina, Peter T, Servan-Mori, Edson E, Shackelford, Katya A, Shaheen, Amira, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A, Singh, Lavanya, Skirbekk, Vegard, Slepak, Erica Leigh, Sliwa, Karen, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Stein, Dan J, Stein, Murray B, Steiner, Caitlyn, Steiner, Timothy J, Stevens, Antony, Stewart, Andrea, Stovner, Lars J, Stroumpoulis, Konstantinos, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R, Ao, Braden J Te, Tediosi, Fabrizio, Temesgen, Awoke M, Templin, Tara, Ten Have, Margreet, Tenkorang, Eric Y, Terkawi, Abdullah S, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tonelli, Marcello, Topouzis, Fotis, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trillini, Matias, Truelsen, Thomas, Tsilimbaris, Miltiadis, Tuzcu, Emin M, Uchendu, Uche S, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uzun, Selen B, Van Brakel, Wim H, Van De Vijver, Steven, van Gool, Coen H, Van Os, Jim, Vasankari, Tommi J, Venketasubramanian, N, Violante, Francesco S, Vlassov, Vasiliy V, Vollset, Stein Emil, Wagner, Gregory R, Wagner, Joseph, Waller, Stephen G, Wan, Xia, Wang, Haidong, Wang, Jianli, Wang, Linhong, Warouw, Tati S, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Wenzhi, Wang, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Thomas N, Wolfe, Charles D, Wolock, Timothy M, Woolf, Anthony D, Wulf, Sarah, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yano, Yuichiro, Ye, Pengpeng, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zonies, David, Zou, Xiaonong, Salomon, Joshua A, Lopez, Alan D, Vos, Theo, Murray, Christopher J L, Barber, Ryan M, Foreman, Kyle J, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Jerry P, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M, Achoki, Tom, Ackerman, Ilana N, Ademi, Zanfina, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, François, Allebeck, Peter, Almazroa, Mohammad A, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ameh, Emmanuel A, Amini, Heresh, Ammar, Walid, Anderson, H Ross, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Avila, Marco A, Awuah, Baffour, Bachman, Victoria F, Badawi, Alaa, Bahit, Maria C, Balakrishnan, Kalpana, Banerjee, Amitava, 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Abstract: BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development. METHODS: We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time. FINDINGS: Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs fell by 3·6% (0
Published: 2015
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5. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, 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Ivy, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stapelberg, Nicolas J C, Stathopoulou, Vasiliki, Steckling, Nadine, Stein, Dan J, Stein, Murray B, Stephens, Natalie, Stöckl, Heidi, Straif, Kurt, Stroumpoulis, Konstantinos, Sturua, Lela, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Talongwa, Roberto T, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Te Ao, Braden J, Teixeira, Carolina M, Téllez Rojo, Martha M, Terkawi, Abdullah S, Texcalac-Sangrador, José Luis, Thackway, Sarah V, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tobollik, Myriam, Tonelli, Marcello, Topouzis, Fotis, Towbin, Jeffrey A, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S, Ukwaja, Kingsley N, Uzun, Selen B, van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H, van Os, Jim, Varakin, Yuri Y, Vasankari, Tommi J, Vasconcelos, Ana Maria N, Vavilala, Monica S, Veerman, Lennert J, Velasquez-Melendez, Gustavo, Venketasubramanian, N, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wallin, Mitchell T, Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S, Watts, Charlotte H, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wessells, K Ryan, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Hywel C, Williams, Thomas N, Woldeyohannes, Solomon M, Wolfe, Charles D A, Wong, John Q, Woolf, Anthony D, Wright, Jonathan L, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R, Lopez, Alan D, Vos, Theo, and Murray, Christopher J
Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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6. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Bora Başara, Berrak, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas K D, Colistro, Valentina, Colomar, Mercedes, 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Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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7. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Kc, Astha, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Cunningham, Solveig Argeseanu, Ärnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Ruvalcaba, Carolina Batis, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Abdulhak, Aref A Bin, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas Kd, Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, Del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Jarlais, Don C Des, Dessalegn, Muluken, deVeber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J, Ferri, Cleusa P, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Foreman, Kyle J, Paleo, Urbano Fra, Franklin, Richard C, Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G, Gansevoort, Ron T, García-Guerra, Francisco A, Gasana, Evariste, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Pete, Gibney, Katherine B, Gillum, Richard F, Ginawi, Ibrahim A M, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Dantes, Hector Gomez, Gona, Philimon, de Cosio, Teresita Gonzalez, González-Castell, Dinorah, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Guerrant, Richard L, Gugnani, Harish C, Guillemin, Francis, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Hafezi-Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A, Hamadeh, Randah R, Hammami, Mouhanad, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I, Hedayati, Mohammad T, Heredia-Pi, Ileana B, Hernandez, Lucia, Heuton, Kyle R, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hornberger, John C, Hosgood, H Dean, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J, Hubbell, Bryan J, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L, Iburg, Kim M, Idrisov, Bulat T, Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H, Jansen, Henrica A, Jarvis, Deborah L, Jassal, Simerjot K, Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Roseline, Sidibe S Kany, Karam, Nadim E, Karch, André, Karema, Corine K, Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A, Khang, 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Traebert, Jefferson, Tran, Bach X, Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S, Ukwaja, Kingsley N, Uzun, Selen B, van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H, van Os, Jim, Varakin, Yuri Y, Vasankari, Tommi J, Vasconcelos, Ana Maria N, Vavilala, Monica S, Veerman, Lennert J, Velasquez-Melendez, Gustavo, Venketasubramanian, N, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wallin, Mitchell T, Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S, Watts, Charlotte H, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wessells, K Ryan, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Hywel C, Williams, Thomas N, Woldeyohannes, Solomon M, Wolfe, Charles D A, Wong, John Q, Woolf, Anthony D, Wright, Jonathan L, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R, Lopez, Alan D, Vos, Theo, and Murray, Christopher J
Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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8. International survey of acute stroke imaging used to make revascularization treatment decisions.

Author: Wintermark, Max, Wintermark, Max, Luby, Marie, Bornstein, Natan M, Demchuk, Andrew, Fiehler, Jens, Kudo, Kohsuke, Lees, Kennedy R, Liebeskind, David S, Michel, Patrik, Nogueira, Raul G, Parsons, Mark W, Sasaki, Makoto, Wardlaw, Joanna M, Wu, Ona, Zhang, Weiwei, Zhu, Guangming, Warach, Steven J, Wintermark, Max, Wintermark, Max, Luby, Marie, Bornstein, Natan M, Demchuk, Andrew, Fiehler, Jens, Kudo, Kohsuke, Lees, Kennedy R, Liebeskind, David S, Michel, Patrik, Nogueira, Raul G, Parsons, Mark W, Sasaki, Makoto, Wardlaw, Joanna M, Wu, Ona, Zhang, Weiwei, Zhu, Guangming, and Warach, Steven J
Abstract: BackgroundTo assess the differences across continental regions in terms of stroke imaging obtained for making acute revascularization therapy decisions, and to identify obstacles to participating in randomized trials involving multimodal imaging.MethodsSTroke Imaging Repository (STIR) and Virtual International Stroke Trials Archive (VISTA)-Imaging circulated an online survey through its website, through the websites of national professional societies from multiple countries as well as through email distribution lists from STIR and the above mentioned societies.ResultsWe received responses from 223 centers (2 from Africa, 38 from Asia, 10 from Australia, 101 from Europe, 4 from Middle East, 55 from North America, 13 from South America). In combination, the sites surveyed administered acute revascularization therapy to a total of 25,326 acute stroke patients in 2012. Seventy-three percent of these patients received intravenous (i.v.) tissue plasminogen activator (tPA), and 27%, endovascular therapy. Vascular imaging was routinely obtained in 79% (152/193) of sites for endovascular therapy decisions, and also as part of standard IV tPA treatment decisions at 46% (92/198) of sites. Modality, availability and use of acute vascular and perfusion imaging before revascularization varied substantially between geographical areas. The main obstacles to participate in randomized trials involving multimodal imaging included: mainly insufficient research support and staff (50%, 79/158) and infrequent use of multimodal imaging (27%, 43/158) .ConclusionThere were significant variations among sites and geographical areas in terms of stroke imaging work-up used tomake decisions both for intravenous and endovascular revascularization. Clinical trials using advanced imaging as a selection tool for acute revascularization therapy should address the need for additional resources and technical support, and take into consideration the lack of routine use of such techniques in trial plannin
Published: 2015

9. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Bora Başara, Berrak, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas K D, Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C, Dessalegn, Muluken, deVeber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, 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Young-Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohannes, Kinge, Jonas M, Kissela, Brett M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Hans, Ku, Tiffany, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G Anil, Kwan, Gene F, Lai, Taavi, Lakshmana Balaji, Arjun, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larson, Heidi J, Larsson, Anders, Laryea, Dennis O, Lavados, Pablo M, Lawrynowicz, Alicia E, Leasher, Janet L, Lee, Jong-Tae, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S, Lindsay, M Patrice, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Logroscino, Giancarlo, London, Stephanie J, Lopez, Nancy, 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Montañez Hernandez, Julio C, Montico, Marcella, Moore, Ami R, Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Mozaffarian, Dariush, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murthy, Kinnari S, Naghavi, Mohsen, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M Venkat, Nash, Denis, Neal, Bruce, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ngalesoni, Frida N, Ngirabega, Jean de Dieu, Nguyen, Grant, Nguyen, Nhung T, Nieuwenhuijsen, Mark J, Nisar, Muhammad I, Nogueira, José R, Nolla, Joan M, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Olusanya, Bolajoko O, Omer, Saad B, Opio, John Nelson, Orozco, Ricardo, Pagcatipunan, Rodolfo S, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Parry, Charles D, Paternina Caicedo, Angel J, Patten, Scott B, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pedraza, Lilia S, Pedroza, Andrea, Pejin Stokic, Ljiljana, Pekericli, Ayfer, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Perry, Samuel A L, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phua, Hwee Pin, Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V, Polinder, Suzanne, Pond, Constance D, Pope, C Arden, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Powles, John, Prabhakaran, Dorairaj, Prasad, Noela M, Qato, Dima M, Quezada, Amado D, Quistberg, D Alex A, Racapé, Lionel, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M, Rao, Mayuree, Razavi, Homie, Reddy, K Srinath, Refaat, Amany H, Rehm, Jürgen, Remuzzi, Giuseppe, Ribeiro, Antonio L, Riccio, Patricia M, Richardson, Lee, Riederer, Anne, Robinson, Margaret, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Romieu, Isabelle, Ronfani, Luca, Room, Robin, Roy, 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I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, 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Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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10. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Bora Başara, Berrak, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas K D, Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M, Contreras, Alejandra G, Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T, Coresh, Josef, Courville, Karen J, Criqui, Michael H, Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, de Castro, E Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C, Dessalegn, Muluken, deVeber, Gabrielle A, Devries, Karen M, Dharmaratne, Samath D, Dherani, Mukesh K, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Durrani, Adnan M, Ebel, Beth E, Ellenbogen, Richard G, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F J, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J, Ferri, Cleusa P, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Foreman, Kyle J, Paleo, Urbano Fra, Franklin, Richard C, Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G, Gansevoort, Ron T, García-Guerra, Francisco A, Gasana, Evariste, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Pete, Gibney, Katherine B, Gillum, Richard F, Ginawi, Ibrahim A M, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Gomez Dantes, Hector, Gona, Philimon, Gonzalez de Cosio, Teresita, González-Castell, Dinorah, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Guerrant, Richard L, Gugnani, Harish C, Guillemin, Francis, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Hafezi-Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A, Hamadeh, Randah R, Hammami, Mouhanad, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I, Hedayati, Mohammad T, Heredia-Pi, Ileana B, Hernandez, Lucia, Heuton, Kyle R, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hornberger, John C, Hosgood, H Dean, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J, Hubbell, Bryan J, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L, Iburg, Kim M, Idrisov, Bulat T, Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H, Jansen, Henrica A, Jarvis, Deborah L, Jassal, Simerjot K, Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Kany Roseline, Sidibe S, Karam, Nadim E, Karch, André, Karema, Corine K, Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A, Khang, Young-Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohannes, Kinge, Jonas M, Kissela, Brett M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Hans, Ku, Tiffany, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G Anil, Kwan, Gene F, Lai, Taavi, Lakshmana Balaji, Arjun, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larson, Heidi J, Larsson, Anders, Laryea, Dennis O, Lavados, Pablo M, Lawrynowicz, Alicia E, Leasher, Janet L, Lee, Jong-Tae, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S, Lindsay, M Patrice, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Logroscino, Giancarlo, London, Stephanie J, Lopez, Nancy, 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Ivy, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stapelberg, Nicolas J C, Stathopoulou, Vasiliki, Steckling, Nadine, Stein, Dan J, Stein, Murray B, Stephens, Natalie, Stöckl, Heidi, Straif, Kurt, Stroumpoulis, Konstantinos, Sturua, Lela, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Talongwa, Roberto T, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Te Ao, Braden J, Teixeira, Carolina M, Téllez Rojo, Martha M, Terkawi, Abdullah S, Texcalac-Sangrador, José Luis, Thackway, Sarah V, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tobollik, Myriam, Tonelli, Marcello, Topouzis, Fotis, Towbin, Jeffrey A, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S, Ukwaja, Kingsley N, Uzun, Selen B, van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H, van Os, Jim, Varakin, Yuri Y, Vasankari, Tommi J, Vasconcelos, Ana Maria N, Vavilala, Monica S, Veerman, Lennert J, Velasquez-Melendez, Gustavo, Venketasubramanian, N, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wallin, Mitchell T, Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S, Watts, Charlotte H, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Wessells, K Ryan, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Hywel C, Williams, Thomas N, Woldeyohannes, Solomon M, Wolfe, Charles D A, Wong, John Q, Woolf, Anthony D, Wright, Jonathan L, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R, Lopez, Alan D, Vos, Theo, and Murray, Christopher J
Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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11. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

Author: Forouzanfar, Mohammad H, Alexander, Lily, Anderson, H Ross, Bachman, Victoria F, Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M, Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J, Astha, K C, Kyu, Hmwe H, Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A, Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M E, Aburto, Tania C, Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Al Khabouri, Mazin J, Al Lami, Faris H, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Aleman, Alicia V, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K, Alla, François, Allebeck, Peter, Allen, Peter J, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A, Amare, Azmeraw T, Ameh, Emmanuel A, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Argeseanu Cunningham, Solveig, Arnlöv, Johan, Arsenijevic, Valentina S Arsic, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Atkinson, Charles, Avila, Marco A, Awuah, Baffour, Badawi, Alaa, Bahit, Maria C, Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Batis Ruvalcaba, Carolina, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bikbov, Boris, Bin Abdulhak, Aref A, Blore, Jed D, Blyth, Fiona M, Bohensky, Megan A, Bora Başara, Berrak, Borges, Guilherme, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J, Brenner, Hermann, Briggs, Adam D M, Broday, David M, Brooks, Peter M, Bruce, Nigel G, Brugha, Traolach S, Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N, Bukhman, Gene, Bulloch, Andrew G, Burch, Michael, Burney, Peter G J, Campos-Nonato, Ismael R, Campuzano, Julio C, Cantoral, Alejandra J, Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A, Chuang, Ting-Wu, Chugh, Sumeet S, Cirillo, Massimo, Claßen, Thomas K D, Colistro, Valentina, Colomar, Mercedes, 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Abstract: BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. METHODS: Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk-outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990-2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the first level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular filtration rate. For most risks, data for exposure were synthesised with a Bayesian meta-regression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. FINDINGS: All risks combined account for 57·2%
Published: 2015
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12. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013:quantifying the epidemiological transition

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Wagner, Margolis, David J, Margono, Christopher, Marzan, Melvin B, Masci, Joseph R, Mashal, Mohammad T, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, Mcgill, Neil W, Mcgrath, John J, Mckee, Martin, Mclain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Meretoja, Atte, Mhimbira, Francis A, Micha, Renata, Miller, Ted R, Mills, Edward J, Mitchell, Philip B, Mock, Charles N, Mohamed Ibrahim, Norlinah, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L D, Monasta, Lorenzo, Montañez Hernandez, Julio C, Montico, Marcella, Montine, Thomas J, Mooney, Meghan D, Moore, Ami R, Moradi-Lakeh, Maziar, Moran, Andrew E, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Moyer, Madeline L, Mozaffarian, Dariush, Msemburi, William T, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murdoch, Michele E, Murray, Joseph, Murthy, Kinnari S, Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M Venkat, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ng, Marie, Ngalesoni, Frida N, Nguyen, Grant, Nisar, Muhammad I, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Ohno, Summer L, Olusanya, Bolajoko O, Opio, John Nelson, Ortblad, Katrina, Ortiz, Alberto, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Park, Jae-Hyun, Patten, Scott B, Patton, George C, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phillips, Bryan K, Phillips, David E, Piel, Frédéric B, Plass, Dietrich, Poenaru, Dan, Polinder, Suzanne, Pope, Daniel, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Pullan, Rachel L, Qato, Dima M, Quistberg, D Alex, Rafay, Anwar, Rahimi, Kazem, Rahman, Sajjad U, Raju, Murugesan, Rana, Saleem M, Razavi, Homie, Reddy, K Srinath, Refaat, Amany, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L, Richardson, Lee, Richardus, Jan Hendrik, Roberts, D Allen, Rojas-Rueda, David, Ronfani, Luca, Roth, Gregory A, Rothenbacher, Dietrich, Rothstein, David H, Rowley, Jane T, Roy, Nobhojit, Ruhago, George M, Saeedi, Mohammad Y, Saha, Sukanta, Sahraian, Mohammad Ali, Sampson, Uchechukwu K A, Sanabria, Juan R, Sandar, Logan, Santos, Itamar S, Satpathy, Maheswar, Sawhney, Monika, Scarborough, Peter, Schneider, Ione J, Schöttker, Ben, Schumacher, Austin E, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serina, Peter T, Servan-Mori, Edson E, Shackelford, Katya A, Shaheen, Amira, Shahraz, Saeid, Shamah Levy, Teresa, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A, Singh, Lavanya, Skirbekk, Vegard, Slepak, Erica Leigh, Sliwa, Karen, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Stein, Dan J, Stein, Murray B, Steiner, Caitlyn, Steiner, Timothy J, Stevens, Antony, Stewart, Andrea, Stovner, Lars J, Stroumpoulis, Konstantinos, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R, Te Ao, Braden J, Tediosi, Fabrizio, Temesgen, Awoke M, Templin, Tara, Ten Have, Margreet, Tenkorang, Eric Y, Terkawi, Abdullah S, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tonelli, Marcello, Topouzis, Fotis, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trillini, Matias, Truelsen, Thomas, Tsilimbaris, Miltiadis, Tuzcu, Emin M, Uchendu, Uche S, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uzun, Selen B, Van Brakel, Wim H, Van De Vijver, Steven, van Gool, Coen H, Van Os, Jim, Vasankari, Tommi J, Venketasubramanian, N, Violante, Francesco S, Vlassov, Vasiliy V, Vollset, Stein Emil, Wagner, Gregory R, Wagner, Joseph, Waller, Stephen G, Wan, Xia, Wang, Haidong, Wang, Jianli, Wang, Linhong, Warouw, Tati S, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Wenzhi, Wang, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Thomas N, Wolfe, Charles D, Wolock, Timothy M, Woolf, Anthony D, Wulf, Sarah, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yano, Yuichiro, Ye, Pengpeng, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zonies, David, Zou, Xiaonong, Salomon, Joshua A, Lopez, Alan D, Vos, Theo, Murray, Christopher J L, Barber, Ryan M, Foreman, Kyle J, Abbasoglu Ozgoren, Ayse, Abd-Allah, Foad, Abera, Semaw F, Aboyans, Victor, Abraham, Jerry P, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M, Achoki, Tom, Ackerman, Ilana N, Ademi, Zanfina, Adou, Arsène K, Adsuar, José C, Afshin, Ashkan, Agardh, Emilie E, Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I, Alegretti, Miguel A, Alemu, Zewdie A, Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, François, Allebeck, Peter, Almazroa, Mohammad A, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amare, Azmeraw T, Ameh, Emmanuel A, Amini, Heresh, Ammar, Walid, Anderson, H Ross, Anderson, Benjamin O, Antonio, Carl Abelardo T, Anwari, Palwasha, Arnlöv, Johan, Arsic Arsenijevic, Valentina S, Artaman, Al, Asghar, Rana J, Assadi, Reza, Atkins, Lydia S, Avila, Marco A, Awuah, Baffour, Bachman, Victoria F, Badawi, Alaa, Bahit, Maria C, Balakrishnan, Kalpana, Banerjee, Amitava, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Bekele, Tolesa, Bell, Michelle L, Benjet, Corina, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Bernabé, Eduardo, Bertozzi-Villa, Amelia, Beyene, Tariku J, Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A, Bienhoff, Kelly, Bikbov, Boris, Biryukov, Stan, Blore, Jed D, Blosser, Christopher D, Blyth, Fiona M, Bohensky, Megan A, Bolliger, Ian W, Bora Başara, Berrak, Bornstein, Natan M, Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R A, Boyers, Lindsay N, Brainin, Michael, Brayne, Carol E, Brazinova, Alexandra, Breitborde, Nicholas J K, Brenner, Hermann, Briggs, Adam D, Brooks, Peter, Brown, Jonathan C, Brugha, Traolach S, Buchbinder, Rachelle, Buckle, Geoffrey C, Budke, Christine M, Bulchis, Anne, Bulloch, Andrew G, Campos-Nonato, Ismael R, Carabin, Hélène, Carapetis, Jonathan R, Cárdenas, Rosario, Carpenter, David O, Caso, Valeria, Castañeda-Orjuela, Carlos A, Castro, Ruben E, Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K, Chang, Jung-Chen, Charlson, Fiona J, Chen, Honglei, Chen, Wanqing, Chiang, Peggy P, Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christensen, Hanne, Christophi, Costas A, Cirillo, Massimo, Coates, Matthew M, Coffeng, Luc E, Coggeshall, Megan S, Colistro, Valentina, Colquhoun, Samantha M, Cooke, Graham S, Cooper, Cyrus, Cooper, Leslie T, Coppola, Luis M, Cortinovis, Monica, Criqui, Michael H, Crump, John A, Cuevas-Nasu, Lucia, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dansereau, Emily, Dargan, Paul I, Davey, Gail, Davis, Adrian, Davitoiu, Dragos V, Dayama, Anand, De Leo, Diego, Degenhardt, Louisa, Del Pozo-Cruz, Borja, Dellavalle, Robert P, Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C, Dessalegn, Muluken, Dharmaratne, Samath D, Dherani, Mukesh K, Diaz-Torné, Cesar, Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E Ray, Driscoll, Tim R, Duan, Leilei, Duber, Herbert C, Ebel, Beth E, Edmond, Karen M, Elshrek, Yousef M, Endres, Matthias, Ermakov, Sergey P, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Estep, Kara, Faraon, Emerito Jose A, Farzadfar, Farshad, Fay, Derek F, Feigin, Valery L, Felson, David T, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Ferrari, Alize J, Fitzmaurice, Christina, Flaxman, Abraham D, Fleming, Thomas D, Foigt, Nataliya, Forouzanfar, Mohammad H, Fowkes, F Gerry R, Paleo, Urbano Fra, Franklin, Richard C, Fürst, Thomas, Gabbe, Belinda, Gaffikin, Lynne, Gankpé, Fortuné G, Geleijnse, Johanna M, Gessner, Bradford D, Gething, Peter, Gibney, Katherine B, Giroud, Maurice, Giussani, Giorgia, Gomez Dantes, Hector, Gona, Philimon, González-Medina, Diego, Gosselin, Richard A, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Graetz, Nicholas, Gugnani, Harish C, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A, Haagsma, Juanita, Hafezi-Nejad, Nima, Hagan, Holly, Halasa, Yara A, Hamadeh, Randah R, Hamavid, Hannah, Hammami, Mouhanad, Hancock, Jamie, Hankey, Graeme J, Hansen, Gillian M, Hao, Yuantao, Harb, Hilda L, Haro, Josep Maria, Havmøller, Rasmus, Hay, Simon I, Hay, Roderick J, Heredia-Pi, Ileana B, Heuton, Kyle R, Heydarpour, Pouria, Higashi, Hideki, Hijar, Martha, Hoek, Hans W, Hoffman, Howard J, Hosgood, H Dean, Hossain, Mazeda, Hotez, Peter J, Hoy, Damian G, Hsairi, Mohamed, Hu, Guoqing, Huang, Cheng, Huang, John J, Husseini, Abdullatif, Huynh, Chantal, Iannarone, Marissa L, Iburg, Kim Moesgaard, Innos, Kaire, Inoue, Manami, Islami, Farhad, Jacobsen, Kathryn H, Jarvis, Deborah L, Jassal, Simerjot K, Jee, Sun Ha, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jonas, Jost B, Juel, Knud, Kan, Haidong, Karch, André, Karema, Corine K, Karimkhani, Chante, Karthikeyan, Ganesan, Kassebaum, Nicholas J, Kaul, Anil, Kawakami, Norito, Kazanjan, Konstantin, Kemp, Andrew H, Kengne, Andre P, Keren, Andre, Khader, Yousef S, Khalifa, Shams Eldin A, Khan, Ejaz A, Khan, Gulfaraz, Khang, Young-Ho, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kinfu, Yohannes, Kinge, Jonas M, Kivipelto, Miia, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kosen, Soewarta, Krishnaswami, Sanjay, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuipers, Ernst J, Kulkarni, Chanda, Kulkarni, Veena S, Kumar, G Anil, Kyu, Hmwe H, Lai, Taavi, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C, Larsson, Anders, Lawrynowicz, Alicia E B, Leasher, Janet L, Leigh, James, Leung, Ricky, Levitz, Carly E, Li, Bin, Li, Yichong, Li, Yongmei, Lim, Stephen S, Lind, Maggie, Lipshultz, Steven E, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lofgren, Katherine T, Logroscino, Giancarlo, Looker, Katharine J, Lortet-Tieulent, Joannie, Lotufo, Paulo A, Lozano, Rafael, Lucas, Robyn M, Lunevicius, Raimundas, Lyons, Ronan A, Ma, Stefan, Macintyre, Michael F, Mackay, Mark T, Majdan, Marek, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marzan, Melvin B, Masci, Joseph R, Mashal, Mohammad T, Matzopoulos, Richard, Mayosi, Bongani M, Mazorodze, Tasara T, Mcgill, Neil W, Mcgrath, John J, Mckee, Martin, Mclain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mekonnen, Wubegzier, Melaku, Yohannes A, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Meretoja, Atte, Mhimbira, Francis A, Micha, Renata, Miller, Ted R, Mills, Edward J, Mitchell, Philip B, Mock, Charles N, Mohamed Ibrahim, Norlinah, Mohammad, Karzan A, Mokdad, Ali H, Mola, Glen L D, Monasta, Lorenzo, Montañez Hernandez, Julio C, Montico, Marcella, Montine, Thomas J, Mooney, Meghan D, Moore, Ami R, Moradi-Lakeh, Maziar, Moran, Andrew E, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Moyer, Madeline L, Mozaffarian, Dariush, Msemburi, William T, Mueller, Ulrich O, Mukaigawara, Mitsuru, Mullany, Erin C, Murdoch, Michele E, Murray, Joseph, Murthy, Kinnari S, Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S, Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K M Venkat, Nejjari, Chakib, Neupane, Sudan P, Newton, Charles R, Ng, Marie, Ngalesoni, Frida N, Nguyen, Grant, Nisar, Muhammad I, Nolte, Sandra, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Ohno, Summer L, Olusanya, Bolajoko O, Opio, John Nelson, Ortblad, Katrina, Ortiz, Alberto, Pain, Amanda W, Pandian, Jeyaraj D, Panelo, Carlo Irwin A, Papachristou, Christina, Park, Eun-Kee, Park, Jae-Hyun, Patten, Scott B, Patton, George C, Paul, Vinod K, Pavlin, Boris I, Pearce, Neil, Pereira, David M, Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B, Petzold, Max, Phillips, Michael R, Phillips, Bryan K, Phillips, David E, Piel, Frédéric B, Plass, Dietrich, Poenaru, Dan, Polinder, Suzanne, Pope, Daniel, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Pullan, Rachel L, Qato, Dima M, Quistberg, D Alex, Rafay, Anwar, Rahimi, Kazem, Rahman, Sajjad U, Raju, Murugesan, Rana, Saleem M, Razavi, Homie, Reddy, K Srinath, Refaat, Amany, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L, Richardson, Lee, Richardus, Jan Hendrik, Roberts, D Allen, Rojas-Rueda, David, Ronfani, Luca, Roth, Gregory A, Rothenbacher, Dietrich, Rothstein, David H, Rowley, Jane T, Roy, Nobhojit, Ruhago, George M, Saeedi, Mohammad Y, Saha, Sukanta, Sahraian, Mohammad Ali, Sampson, Uchechukwu K A, Sanabria, Juan R, Sandar, Logan, Santos, Itamar S, Satpathy, Maheswar, Sawhney, Monika, Scarborough, Peter, Schneider, Ione J, Schöttker, Ben, Schumacher, Austin E, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Serina, Peter T, Servan-Mori, Edson E, Shackelford, Katya A, Shaheen, Amira, Shahraz, Saeid, Shamah Levy, Teresa, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga D, Silberberg, Donald H, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Jasvinder A, Singh, Lavanya, Skirbekk, Vegard, Slepak, Erica Leigh, Sliwa, Karen, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Stein, Dan J, Stein, Murray B, Steiner, Caitlyn, Steiner, Timothy J, Stevens, Antony, Stewart, Andrea, Stovner, Lars J, Stroumpoulis, Konstantinos, Sunguya, Bruno F, Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L, Tabb, Karen M, Takahashi, Ken, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R, Te Ao, Braden J, Tediosi, Fabrizio, Temesgen, Awoke M, Templin, Tara, Ten Have, Margreet, Tenkorang, Eric Y, Terkawi, Abdullah S, Thomson, Blake, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tonelli, Marcello, Topouzis, Fotis, Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X, Trillini, Matias, Truelsen, Thomas, Tsilimbaris, Miltiadis, Tuzcu, Emin M, Uchendu, Uche S, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uzun, Selen B, Van Brakel, Wim H, Van De Vijver, Steven, van Gool, Coen H, Van Os, Jim, Vasankari, Tommi J, Venketasubramanian, N, Violante, Francesco S, Vlassov, Vasiliy V, Vollset, Stein Emil, Wagner, Gregory R, Wagner, Joseph, Waller, Stephen G, Wan, Xia, Wang, Haidong, Wang, Jianli, Wang, Linhong, Warouw, Tati S, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Wenzhi, Wang, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Williams, Thomas N, Wolfe, Charles D, Wolock, Timothy M, Woolf, Anthony D, Wulf, Sarah, Wurtz, Brittany, Xu, Gelin, Yan, Lijing L, Yano, Yuichiro, Ye, Pengpeng, Yentür, Gökalp K, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaki, Maysaa E, Zhao, Yong, Zheng, Yingfeng, Zonies, David, Zou, Xiaonong, Salomon, Joshua A, Lopez, Alan D, and Vos, Theo
Abstract: BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative assessments of broad epidemiological patterns across countries and time. These summary measures can also be used to quantify the component of variation in epidemiology that is related to sociodemographic development.METHODS: We used the published GBD 2013 data for age-specific mortality, years of life lost due to premature mortality (YLLs), and years lived with disability (YLDs) to calculate DALYs and HALE for 1990, 1995, 2000, 2005, 2010, and 2013 for 188 countries. We calculated HALE using the Sullivan method; 95% uncertainty intervals (UIs) represent uncertainty in age-specific death rates and YLDs per person for each country, age, sex, and year. We estimated DALYs for 306 causes for each country as the sum of YLLs and YLDs; 95% UIs represent uncertainty in YLL and YLD rates. We quantified patterns of the epidemiological transition with a composite indicator of sociodemographic status, which we constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population. We applied hierarchical regression to DALY rates by cause across countries to decompose variance related to the sociodemographic status variable, country, and time.FINDINGS: Worldwide, from 1990 to 2013, life expectancy at birth rose by 6·2 years (95% UI 5·6-6·6), from 65·3 years (65·0-65·6) in 1990 to 71·5 years (71·0-71·9) in 2013, HALE at birth rose by 5·4 years (4·9-5·8), from 56·9 years (54·5-59·1) to 62·3 years (59·7-64·8), total DALYs
Published: 2015

13. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Stroke Synergium, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, and Stroke Synergium
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent 'silo' mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized
Published: 2010

14. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, and Tuomilehto, Jaakko
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by seven working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent 'silo' mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralize
Published: 2010

15. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, and Tuomilehto, Jaakko
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent "silo" mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized el
Published: 2010

16. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

Author: Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, Soreq, Hermona, Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, and Soreq, Hermona
Abstract: To date there is no diagnostic biomarker for mild stroke, although elevation of inflammatory biomarkers has been reported at early stages. Previous studies implicated acetylcholinesterase (AChE) involvement in stroke, and circulating AChE activity reflects inflammatory response, since acetylcholine suppresses inflammation. Therefore, carriers of polymorphisms that modify cholinergic activity should be particularly susceptible to inflammatory damage. Our study sought diagnostic values of AChE and Cholinergic Status (CS, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. For this purpose, serum cholinesterase activities, butyrylcholinesterase-K genotype and inflammatory biomarkers were determined in 264 ischemic stroke patients and matched controls during the acute phase. AChE activities were lower (P<0.001), and butyrylcholinesterase activities were higher in patients than in controls (P=0.004). When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001). Furthermore, very low AChE activities predicted subsequent nonsurvival (P=0.036). Also, carriers of the unstable butyrylcholinesterase-K variant were more abundant among patients than controls, and showed reduced activity (P<0.001). Importantly, a cholinergic score combining the two cholinesterase activities discriminated between 94.3% matched pairs of patients and controls, compared with only 75% for inflammatory measures. Our findings present the power of circulation cholinesterase measurements as useful early diagnostic tools for the occurrence of stroke. Importantly, these were considerably more distinctive than the inflammatory biomarkers, albeit closely associated with them, which may open new venues for stroke diagnosis and treatment.
Published: 2010

17. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Stroke Synergium, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, and Stroke Synergium
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent 'silo' mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (e.g., social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized
Published: 2010

18. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, and Tuomilehto, Jaakko
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by 7 working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent "silo" mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralized el
Published: 2010

19. Stroke: working toward a prioritized world agenda.

Author: Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, Tuomilehto, Jaakko, Hachinski, Vladimir, Hachinski, Vladimir, Donnan, Geoffrey A, Gorelick, Philip B, Hacke, Werner, Cramer, Steven C, Kaste, Markku, Fisher, Marc, Brainin, Michael, Buchan, Alastair M, Lo, Eng H, Skolnick, Brett E, Furie, Karen L, Hankey, Graeme J, Kivipelto, Miia, Morris, John, Rothwell, Peter M, Sacco, Ralph L, Smith, Sidney C, Wang, Yulun, Bryer, Alan, Ford, Gary A, Iadecola, Costantino, Martins, Sheila CO, Saver, Jeff, Skvortsova, Veronika, Bayley, Mark, Bednar, Martin M, Duncan, Pamela, Enney, Lori, Finklestein, Seth, Jones, Theresa A, Kalra, Lalit, Kleim, Jeff, Nitkin, Ralph, Teasell, Robert, Weiller, Cornelius, Desai, Bhupat, Goldberg, Mark P, Heiss, Wolf-Dieter, Saarelma, Osmo, Schwamm, Lee H, Shinohara, Yukito, Trivedi, Bhargava, Wahlgren, Nils, Wong, Lawrence K, Hakim, Antoine, Norrving, Bo, Prudhomme, Stephen, Bornstein, Natan M, Davis, Stephen M, Goldstein, Larry B, Leys, Didier, and Tuomilehto, Jaakko
Abstract: Background and purposeThe aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke.MethodsPreliminary work was performed by seven working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document had further input from contributors outside the synergium.ResultsRecommendations of the Synergium are: Basic Science, Drug Development and Technology: There is a need to develop: (1) New systems of working together to break down the prevalent 'silo' mentality; (2) New models of vertically integrated basic, clinical, and epidemiological disciplines; and (3) Efficient methods of identifying other relevant areas of science. Stroke Prevention: (1) Establish a global chronic disease prevention initiative with stroke as a major focus. (2) Recognize not only abrupt clinical stroke, but subtle subclinical stroke, the commonest type of cerebrovascular disease, leading to impairments of executive function. (3) Develop, implement and evaluate a population approach for stroke prevention. (4) Develop public health communication strategies using traditional and novel (eg, social media/marketing) techniques. Acute Stroke Management: Continue the establishment of stroke centers, stroke units, regional systems of emergency stroke care and telestroke networks. Brain Recovery and Rehabilitation: (1) Translate best neuroscience, including animal and human studies, into poststroke recovery research and clinical care. (2) Standardize poststroke rehabilitation based on best evidence. (3) Develop consensus on, then implementation of, standardized clinical and surrogate assessments. (4) Carry out rigorous clinical research to advance stroke recovery. Into the 21st Century: Web, Technology and Communications: (1) Work toward global unrestricted access to stroke-related information. (2) Build centralize
Published: 2010

20. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

Author: Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, Soreq, Hermona, Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, and Soreq, Hermona
Abstract: To date there is no diagnostic biomarker for mild stroke, although elevation of inflammatory biomarkers has been reported at early stages. Previous studies implicated acetylcholinesterase (AChE) involvement in stroke, and circulating AChE activity reflects inflammatory response, since acetylcholine suppresses inflammation. Therefore, carriers of polymorphisms that modify cholinergic activity should be particularly susceptible to inflammatory damage. Our study sought diagnostic values of AChE and Cholinergic Status (CS, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. For this purpose, serum cholinesterase activities, butyrylcholinesterase-K genotype and inflammatory biomarkers were determined in 264 ischemic stroke patients and matched controls during the acute phase. AChE activities were lower (P<0.001), and butyrylcholinesterase activities were higher in patients than in controls (P=0.004). When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001). Furthermore, very low AChE activities predicted subsequent nonsurvival (P=0.036). Also, carriers of the unstable butyrylcholinesterase-K variant were more abundant among patients than controls, and showed reduced activity (P<0.001). Importantly, a cholinergic score combining the two cholinesterase activities discriminated between 94.3% matched pairs of patients and controls, compared with only 75% for inflammatory measures. Our findings present the power of circulation cholinesterase measurements as useful early diagnostic tools for the occurrence of stroke. Importantly, these were considerably more distinctive than the inflammatory biomarkers, albeit closely associated with them, which may open new venues for stroke diagnosis and treatment.
Published: 2010

21. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

Author: Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, Soreq, Hermona, Ben Assayag, Einor, Shenhar-Tsarfaty, Shani, Ofek, Keren, Soreq, Lilach, Bova, Irena, Shopin, Ludmila, Berg, Ronan M G, Berliner, Shlomo, Shapira, Itzhak, Bornstein, Natan M, and Soreq, Hermona
Abstract: To date there is no diagnostic biomarker for mild stroke, although elevation of inflammatory biomarkers has been reported at early stages. Previous studies implicated acetylcholinesterase (AChE) involvement in stroke, and circulating AChE activity reflects inflammatory response, since acetylcholine suppresses inflammation. Therefore, carriers of polymorphisms that modify cholinergic activity should be particularly susceptible to inflammatory damage. Our study sought diagnostic values of AChE and Cholinergic Status (CS, the total capacity for acetylcholine hydrolysis) in suspected stroke patients. For this purpose, serum cholinesterase activities, butyrylcholinesterase-K genotype and inflammatory biomarkers were determined in 264 ischemic stroke patients and matched controls during the acute phase. AChE activities were lower (P<0.001), and butyrylcholinesterase activities were higher in patients than in controls (P=0.004). When normalized to sampling time from stroke occurrence, both cholinergic parameters were correlated with multiple inflammatory biomarkers, including fibrinogen, interleukin-6 and C-reactive protein (r=0.713, r=0.607; r=0.421, r=0.341; r=0.276, r=0.255; respectively; all P values<0.001). Furthermore, very low AChE activities predicted subsequent nonsurvival (P=0.036). Also, carriers of the unstable butyrylcholinesterase-K variant were more abundant among patients than controls, and showed reduced activity (P<0.001). Importantly, a cholinergic score combining the two cholinesterase activities discriminated between 94.3% matched pairs of patients and controls, compared with only 75% for inflammatory measures. Our findings present the power of circulation cholinesterase measurements as useful early diagnostic tools for the occurrence of stroke. Importantly, these were considerably more distinctive than the inflammatory biomarkers, albeit closely associated with them, which may open new venues for stroke diagnosis and treatment.
Published: 2010

22. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Author: Forouzanfar, Mohammad H., Alexander, Lily, Anderson, H. Ross, Bachman, Victoria F., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M., Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J., KC, Astha, Kyu, Hmwe H., Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A., Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F., Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M. E., Aburto, Tania C., Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K., Adsuar, José C., Afshin, Ashkan, Agardh, Emilie E., Al Khabouri, Mazin J., Al Lami, Faris H., Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I., Alegretti, Miguel A., Aleman, Alicia V., Alemu, Zewdie A., Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K., Alla, François, Allebeck, Peter, Allen, Peter J., Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A., Amare, Azmeraw T., Ameh, Emmanuel A., Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwari, Palwasha, Cunningham, Solveig Argeseanu, Arnlöv, Johan, Arsenijevic, Valentina S. Arsic, Artaman, Al, Asghar, Rana J., Assadi, Reza, Atkins, Lydia S., Atkinson, Charles, Avila, Marco A., Awuah, Baffour, Badawi, Alaa, Bahit, Maria C., Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M., Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lars, Barrero, Lope H., Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C., Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O., Ruvalcaba, Carolina Batis, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L., Benjet, Corina, Bennett, Derrick A., Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J., Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A., Bikbov, Boris, Abdulhak, Aref A. Bin, Blore, Jed D., Blyth, Fiona M., Bohensky, Megan A., Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M., Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J., Brenner, Hermann, Briggs, Adam D. M., Broday, David M., Brooks, Peter M., Bruce, Nigel G., Brugha, Traolach S., Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N., Bukhman, Gene, Bulloch, Andrew G., Burch, Michael, Burney, Peter G. J., Campos-Nonato, Ismael R., Campuzano, Julio C., Cantoral, Alejandra J., Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O., Caso, Valeria, Castañeda-Orjuela, Carlos A., Castro, Ruben E., Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K., Chang, Jung-chen, Charlson, Fiona J., Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P., Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A., Chuang, Ting-Wu, Chugh, Sumeet S., Cirillo, Massimo, Claßen, Thomas K. D., Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M., Contreras, Alejandra G., Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T., Coresh, Josef, Courville, Karen J., Criqui, Michael H., Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Davis, Adrian, Davitoiu, Dragos V., Dayama, Anand, de Castro, E. Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribe, Kebede, Derrett, Sarah, Jarlais, Don C. Des, Dessalegn, Muluken, deVeber, Gabrielle A., Devries, Karen M., Dharmaratne, Samath D., Dherani, Mukesh K., Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E. Ray, Driscoll, Tim R., Duan, Leilei, Durrani, Adnan M., Ebel, Beth E., Ellenbogen, Richard G., Elshrek, Yousef M., Endres, Matthias, Ermakov, Sergey P., Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A., Farzadfar, Farshad, Fay, Derek F. J., Feigin, Valery L., Feigl, Andrea B., Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J., Ferri, Cleusa P., Flaxman, Abraham D., Fleming, Thomas D., Foigt, Nataliya, Foreman, Kyle J., Paleo, Urbano Fra, Franklin, Richard C., Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G., Gansevoort, Ron T., García-Guerra, Francisco A., Gasana, Evariste, Geleijnse, Johanna M., Gessner, Bradford D., Gething, Pete, Gibney, Katherine B., Gillum, Richard F., Ginawi, Ibrahim A. M., Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Dantes, Hector Gomez, Gona, Philimon, de Cosio, Teresita Gonzalez, González-Castell, Dinorah, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Guerrant, Richard L., Gugnani, Harish C., Guillemin, Francis, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A., Hafezi-Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A., Hamadeh, Randah R., Hammami, Mouhanad, Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I., Hedayati, Mohammad T., Heredia-Pi, Ileana B., Hernandez, Lucia, Heuton, Kyle R., Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W., Hoffman, Howard J., Hornberger, John C., Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J., Hubbell, Bryan J., Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L., Iburg, Kim M., Idrisov, Bulat T., Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H., Jansen, Henrica A., Jarvis, Deborah L., Jassal, Simerjot K., Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B., Juel, Knud, Kan, Haidong, Roseline, Sidibe S Kany, Karam, Nadim E., Karch, André, Karema, Corine K., Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Kemp, Andrew H., Kengne, Andre P., Keren, Andre, Khader, Yousef S., Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A., Khang, Young-Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohannes, Kinge, Jonas M., Kissela, Brett M., Kivipelto, Miia, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M. Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J., Kulkarni, Chanda, Kulkarni, Veena S., Kumar, G. Anil, Kwan, Gene F., Lai, Taavi, Balaji, Arjun Lakshmana, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C., Larson, Heidi J., Larsson, Anders, Laryea, Dennis O., Lavados, Pablo M., Lawrynowicz, Alicia E., Leasher, Janet L., Lee, Jong-Tae, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S., Lindsay, M. Patrice, Lipshultz, Steven E., Liu, Shiwei, Liu, Yang, Lloyd, Belinda K., Logroscino, Giancarlo, London, Stephanie J., Lopez, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Ma, Jixiang, Ma, Stefan, Machado, Vasco M. P., MacIntyre, Michael F., Magis-Rodriguez, Carlos, Mahdi, Abbas A., Majdan, Marek, Malekzadeh, Reza, Mangalam, Srikanth, Mapoma, Christopher C., Marape, Marape, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marks, Guy B., Martin, Randall V., Marzan, Melvin B., Mashal, Mohammad T., Masiye, Felix, Mason-Jones, Amanda J., Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., Mazorodze, Tasara T., McKay, Abigail C., McKee, Martin, McLain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A., Meltzer, Michele, Memish, Ziad A., Mendoza, Walter, Mensah, George A., Meretoja, Atte, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R., Mills, Edward J., Misganaw, Awoke, Mishra, Santosh, Ibrahim, Norlinah Mohamed, Mohammad, Karzan A., Mokdad, Ali H., Mola, Glen L., Monasta, Lorenzo, Hernandez, Julio C. Montañez, Montico, Marcella, Moore, Ami R, Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N, Mozaffarian, Dariush, Mueller, Ulrich O., Mukaigawara, Mitsuru, Mullany, Erin C., Murthy, Kinnari S., Naghavi, Mohsen, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S., Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, KM Venkat, Nash, Denis, Neal, Bruce, Nejjari, Chakib, Neupane, Sudan P., Newton, Charles R., Ngalesoni, Frida N., de Dieu Ngirabega, Jean, Nguyen, Grant, Nguyen, Nhung T., Nieuwenhuijsen, Mark J., Nisar, Muhammad I., Nogueira, José R., Nolla, Joan M., Nolte, Sandra, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Oh, In-Hwan, Ohkubo, Takayoshi, Olusanya, Bolajoko O., Omer, Saad B., Opio, John Nelson, Orozco, Ricardo, Pagcatipunan, Rodolfo S., Pain, Amanda W., Pandian, Jeyaraj D., Panelo, Carlo Irwin A., Papachristou, Christina, Park, Eun-Kee, Parry, Charles D., Caicedo, Angel J. Paternina, Patten, Scott B., Paul, Vinod K., Pavlin, Boris I., Pearce, Neil, Pedraza, Lilia S., Pedroza, Andrea, Stokic, Ljiljana Pejin, Pekericli, Ayfer, Pereira, David M., Perez-Padilla, Rogelio, Perez-Ruiz, Fernando, Perico, Norberto, Perry, Samuel A. L., Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B., Petzold, Max, Phillips, Michael R., Phua, Hwee Pin, Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V., Polinder, Suzanne, Pond, Constance D., Pope, C. Arden, Pope, Daniel, Popova, Svetlana, Pourmalek, Farshad, Powles, John, Prabhakaran, Dorairaj, Prasad, Noela M., Qato, Dima M., Quezada, Amado D., Quistberg, D. Alex A., Racapé, Lionel, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M., Rao, Mayuree, Razavi, Homie, Reddy, K. Srinath, Refaat, Amany H., Rehm, Jürgen, Remuzzi, Giuseppe, Ribeiro, Antonio L., Riccio, Patricia M., Richardson, Lee, Riederer, Anne, Robinson, Margaret, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Romieu, Isabelle, Ronfani, Luca, Room, Robin, Roy, Nobhojit, Ruhago, George M., Rushton, Lesley, Sabin, Nsanzimana, Sacco, Ralph L, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Salomon, Joshua A., Salvo, Deborah, Sampson, Uchechukwu K., Sanabria, Juan R., Sanchez, Luz Maria, Sánchez-Pimienta, Tania G., Sanchez-Riera, Lidia, Sandar, Logan, Santos, Itamar S., Sapkota, Amir, Satpathy, Maheswar, Saunders, James E., Sawhney, Monika, Saylan, Mete I., Scarborough, Peter, Schmidt, Jürgen C., Schneider, Ione J. C., Schöttker, Ben, Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Serdar, Berrin, Servan-Mori, Edson E., Shaddick, Gavin, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shibuya, Kenji, Shin, Hwashin H., Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Sigfusdottir, Inga D., Silberberg, Donald H., Simard, Edgar P., Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M., Singh, Jasvinder A., Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Søreide, Kjetil, Soshnikov, Sergey, Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stapelberg, Nicolas J. C., Stathopoulou, Vasiliki, Steckling, Nadine, Stein, Dan J., Stein, Murray B., Stephens, Natalie, Stöckl, Heidi, Straif, Kurt, Stroumpoulis, Konstantinos, Sturua, Lela, Sunguya, Bruno F., Swaminathan, Soumya, Swaroop, Mamta, Sykes, Bryan L., Tabb, Karen M., Takahashi, Ken, Talongwa, Roberto T., Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Te Ao, Braden J., Teixeira, Carolina M., Téllez Rojo, Martha M., Terkawi, Abdullah S., Texcalac-Sangrador, José Luis, Thackway, Sarah V., Thomson, Blake, Thorne-Lyman, Andrew L., Thrift, Amanda G., Thurston, George D., Tillmann, Taavi, Tobollik, Myriam, Tonelli, Marcello, Topouzis, Fotis, Towbin, Jeffrey A., Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X., Trasande, Leonardo, Trillini, Matias, Trujillo, Ulises, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadis, Tuzcu, Emin Murat, Uchendu, Uche S., Ukwaja, Kingsley N., Uzun, Selen B., van de Vijver, Steven, Van Dingenen, Rita, van Gool, Coen H., van Os, Jim, Varakin, Yuri Y., Vasankari, Tommi J., Vasconcelos, Ana Maria N., Vavilala, Monica S., Veerman, Lennert J., Velasquez-Melendez, Gustavo, Venketasubramanian, N., Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R., Waller, Stephen G., Wallin, Mitchell T., Wan, Xia, Wang, Haidong, Wang, JianLi, Wang, Linhong, Wang, Wenzhi, Wang, Yanping, Warouw, Tati S., Watts, Charlotte H., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Wessells, K. Ryan, Westerman, Ronny, Whiteford, Harvey A., Wilkinson, James D., Williams, Hywel C., Williams, Thomas N., Woldeyohannes, Solomon M., Wolfe, Charles D. A., Wong, John Q., Woolf, Anthony D., Wright, Jonathan L., Wurtz, Brittany, Xu, Gelin, Yan, Lijing L., Yang, Gonghuan, Yano, Yuichiro, Ye, Pengpeng, Yenesew, Muluken, Yentür, Gökalp K., Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z., Younoussi, Zourkaleini, Yu, Chuanhua, Zaki, Maysaa E., Zhao, Yong, Zheng, Yingfeng, Zhou, Maigeng, Zhu, Jun, Zhu, Shankuan, Zou, Xiaonong, Zunt, Joseph R., Lopez, Alan D., Vos, Theo, Murray, Christopher J., Forouzanfar, Mohammad H., Alexander, Lily, Anderson, H. Ross, Bachman, Victoria F., Biryukov, Stan, Brauer, Michael, Burnett, Richard, Casey, Daniel, Coates, Matthew M., Cohen, Aaron, Delwiche, Kristen, Estep, Kara, Frostad, Joseph J., KC, Astha, Kyu, Hmwe H., Moradi-Lakeh, Maziar, Ng, Marie, Slepak, Erica Leigh, Thomas, Bernadette A., Wagner, Joseph, Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Abera, Semaw F., Aboyans, Victor, Abraham, Biju, Abraham, Jerry Puthenpurakal, Abubakar, Ibrahim, Abu-Rmeileh, Niveen M. E., Aburto, Tania C., Achoki, Tom, Adelekan, Ademola, Adofo, Koranteng, Adou, Arsène K., Adsuar, José C., Afshin, Ashkan, Agardh, Emilie E., Al Khabouri, Mazin J., Al Lami, Faris H., Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I., Alegretti, Miguel A., Aleman, Alicia V., Alemu, Zewdie A., Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Ali, Mohammed K., Alla, François, Allebeck, Peter, Allen, Peter J., Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Amankwaa, Adansi A., Amare, Azmeraw T., Ameh, Emmanuel A., Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O., Antonio, Carl Abelardo T., Anwari, Palwasha, Cunningham, Solveig Argeseanu, Arnlöv, Johan, Arsenijevic, Valentina S. Arsic, Artaman, Al, Asghar, Rana J., Assadi, Reza, Atkins, Lydia S., Atkinson, Charles, Avila, Marco A., Awuah, Baffour, Badawi, Alaa, Bahit, Maria C., Bakfalouni, Talal, Balakrishnan, Kalpana, Balalla, Shivanthi, Balu, Ravi Kumar, Banerjee, Amitava, Barber, Ryan M., Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lars, Barrero, Lope H., Barrientos-Gutierrez, Tonatiuh, Basto-Abreu, Ana C., Basu, Arindam, Basu, Sanjay, Basulaiman, Mohammed O., Ruvalcaba, Carolina Batis, Beardsley, Justin, Bedi, Neeraj, Bekele, Tolesa, Bell, Michelle L., Benjet, Corina, Bennett, Derrick A., Benzian, Habib, Bernabé, Eduardo, Beyene, Tariku J., Bhala, Neeraj, Bhalla, Ashish, Bhutta, Zulfiqar A., Bikbov, Boris, Abdulhak, Aref A. Bin, Blore, Jed D., Blyth, Fiona M., Bohensky, Megan A., Başara, Berrak Bora, Borges, Guilherme, Bornstein, Natan M., Bose, Dipan, Boufous, Soufiane, Bourne, Rupert R., Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J., Brenner, Hermann, Briggs, Adam D. M., Broday, David M., Brooks, Peter M., Bruce, Nigel G., Brugha, Traolach S., Brunekreef, Bert, Buchbinder, Rachelle, Bui, Linh N., Bukhman, Gene, Bulloch, Andrew G., Burch, Michael, Burney, Peter G. J., Campos-Nonato, Ismael R., Campuzano, Julio C., Cantoral, Alejandra J., Caravanos, Jack, Cárdenas, Rosario, Cardis, Elisabeth, Carpenter, David O., Caso, Valeria, Castañeda-Orjuela, Carlos A., Castro, Ruben E., Catalá-López, Ferrán, Cavalleri, Fiorella, Çavlin, Alanur, Chadha, Vineet K., Chang, Jung-chen, Charlson, Fiona J., Chen, Honglei, Chen, Wanqing, Chen, Zhengming, Chiang, Peggy P., Chimed-Ochir, Odgerel, Chowdhury, Rajiv, Christophi, Costas A., Chuang, Ting-Wu, Chugh, Sumeet S., Cirillo, Massimo, Claßen, Thomas K. D., Colistro, Valentina, Colomar, Mercedes, Colquhoun, Samantha M., Contreras, Alejandra G., Cooper, Cyrus, Cooperrider, Kimberly, Cooper, Leslie T., Coresh, Josef, Courville, Karen J., Criqui, Michael H., Cuevas-Nasu, Lucia, Damsere-Derry, James, Danawi, Hadi, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Davis, Adrian, Davitoiu, Dragos V., Dayama, Anand, de Castro, E. Filipa, De la Cruz-Góngora, Vanessa, De Leo, Diego, de Lima, Graça, Degenhardt, Louisa, del Pozo-Cruz, Borja, Dellavalle, Robert P., Deribe, Kebede, Derrett, Sarah, Jarlais, Don C. Des, Dessalegn, Muluken, deVeber, Gabrielle A., Devries, Karen M., Dharmaratne, Samath D., Dherani, Mukesh K., Dicker, Daniel, Ding, Eric L, Dokova, Klara, Dorsey, E. Ray, Driscoll, Tim R., Duan, Leilei, Durrani, Adnan M., Ebel, Beth E., Ellenbogen, Richard G., Elshrek, Yousef M., Endres, Matthias, Ermakov, Sergey P., Erskine, Holly E., Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Faraon, Emerito Jose A., Farzadfar, Farshad, Fay, Derek F. J., Feigin, Valery L., Feigl, Andrea B., Fereshtehnejad, Seyed-Mohammad, Ferrari, Alize J., Ferri, Cleusa P., Flaxman, Abraham D., Fleming, Thomas D., Foigt, Nataliya, Foreman, Kyle J., Paleo, Urbano Fra, Franklin, Richard C., Gabbe, Belinda, Gaffikin, Lynne, Gakidou, Emmanuela, Gamkrelidze, Amiran, Gankpé, Fortuné G., Gansevoort, Ron T., García-Guerra, Francisco A., Gasana, Evariste, Geleijnse, Johanna M., Gessner, Bradford D., Gething, Pete, Gibney, Katherine B., Gillum, Richard F., Ginawi, Ibrahim A. M., Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goginashvili, Ketevan, Dantes, Hector Gomez, Gona, Philimon, de Cosio, Teresita Gonzalez, González-Castell, Dinorah, Gotay, Carolyn C., Goto, Atsushi, Gouda, Hebe N., Guerrant, Richard L., Gugnani, Harish C., Guillemin, Francis, Gunnell, David, Gupta, Rahul, Gupta, Rajeev, Gutiérrez, Reyna A., Hafezi-Nejad, Nima, Hagan, Holly, Hagstromer, Maria, Halasa, Yara A., Hamadeh, Randah R., Hammami, Mouhanad, Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Haregu, Tilahun Nigatu, Haro, Josep Maria, Havmoeller, Rasmus, Hay, Simon I., Hedayati, Mohammad T., Heredia-Pi, Ileana B., Hernandez, Lucia, Heuton, Kyle R., Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W., Hoffman, Howard J., Hornberger, John C., Hosgood, H. Dean, Hoy, Damian G., Hsairi, Mohamed, Hu, Guoqing, Hu, Howard, Huang, Cheng, Huang, John J., Hubbell, Bryan J., Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa L., Iburg, Kim M., Idrisov, Bulat T., Ikeda, Nayu, Innos, Kaire, Inoue, Manami, Islami, Farhad, Ismayilova, Samaya, Jacobsen, Kathryn H., Jansen, Henrica A., Jarvis, Deborah L., Jassal, Simerjot K., Jauregui, Alejandra, Jayaraman, Sudha, Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jiang, Fan, Jiang, Guohong, Jiang, Ying, Jonas, Jost B., Juel, Knud, Kan, Haidong, Roseline, Sidibe S Kany, Karam, Nadim E., Karch, André, Karema, Corine K., Karthikeyan, Ganesan, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Kemp, Andrew H., Kengne, Andre P., Keren, Andre, Khader, Yousef S., Khalifa, Shams Eldin Ali Hassan, Khan, Ejaz A., Khang, Young-Ho, Khatibzadeh, Shahab, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kim, Yunjin, Kimokoti, Ruth W, Kinfu, Yohannes, Kinge, Jonas M., Kissela, Brett M., Kivipelto, Miia, Knibbs, Luke D., Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kose, M. Rifat, Kosen, Soewarta, Kraemer, Alexander, Kravchenko, Michael, Krishnaswami, Sanjay, Kromhout, Hans, Ku, Tiffany, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J., Kulkarni, Chanda, Kulkarni, Veena S., Kumar, G. Anil, Kwan, Gene F., Lai, Taavi, Balaji, Arjun Lakshmana, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lan, Qing, Lansingh, Van C., Larson, Heidi J., Larsson, Anders, Laryea, Dennis O., Lavados, Pablo M., Lawrynowicz, Alicia E., Leasher, Janet L., Lee, Jong-Tae, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liang, Xiaofeng, Lim, Stephen S., Lindsay, M. Patrice, Lipshultz, Steven E., Liu, Shiwei, Liu, Yang, Lloyd, Belinda K., Logroscino, Giancarlo, London, Stephanie J., Lopez, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Ma, Jixiang, Ma, Stefan, Machado, Vasco M. P., MacIntyre, Michael F., Magis-Rodriguez, Carlos, Mahdi, Abbas A., Majdan, Marek, Malekzadeh, Reza, Mangalam, Srikanth, Mapoma, Christopher C., Marape, Marape, Marcenes, Wagner, Margolis, David J, Margono, Christopher, Marks, Guy B., Martin, Randall V., Marzan, Melvin B., Mashal, Mohammad T., Masiye, Felix, Mason-Jones, Amanda J., Matsushita, Kunihiro, Matzopoulos, Richard, Mayosi, Bongani M., Mazorodze, Tasara T., McKay, Abigail C., McKee, Martin, McLain, Abigail, Meaney, Peter A, Medina, Catalina, Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A., Meltzer, Michele, Memish, Ziad A., Mendoza, Walter, Mensah, George A., Meretoja, Atte, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R., Mills, Edward J., Misganaw, Awoke, Mishra, Santosh, Ibrahim, Norlinah Mohamed, Mohammad, Karzan A., Mokdad, Ali H., Mola, Glen L., Monasta, Lorenzo, Hernandez, Julio C. 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Abstract: Summary Background The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the fi rst of a series of annual updates of the GBD. Risk factor quantifi cation, particularly of modifi able risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution. Methods Attributable deaths, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) have been estimated for 79 risks or clusters of risks using the GBD 2010 methods. Risk–outcome pairs meeting explicit evidence criteria were assessed for 188 countries for the period 1990–2013 by age and sex using three inputs: risk exposure, relative risks, and the theoretical minimum risk exposure level (TMREL). Risks are organised into a hierarchy with blocks of behavioural, environmental and occupational, and metabolic risks at the fi rst level of the hierarchy. The next level in the hierarchy includes nine clusters of related risks and two individual risks, with more detail provided at levels 3 and 4 of the hierarchy. Compared with GBD 2010, six new risk factors have been added: handwashing practices, occupational exposure to trichloroethylene, childhood wasting, childhood stunting, unsafe sex, and low glomerular fi ltration rate. For most risks, data for exposure were synthesised with a Bayesian metaregression method, DisMod-MR 2.0, or spatial-temporal Gaussian process regression. Relative risks were based on meta-regressions of published cohort and intervention studies. Attributable burden for clusters of risks and all risks combined took into account evidence on the mediation of some risks such as high body-mass index (BMI) through other risks such as high systolic blood pressure and high cholesterol. Findings All risks combined account

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22 results on '"Bornstein, Natan M."'

1. Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020

2. Delivery of acute ischaemic stroke treatments in the European region in 2019 and 2020

3. Colchicine for prevention of vascular inflammation in Non-CardioEmbolic stroke (CONVINCE) – study protocol for a randomised controlled trial

4. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013 : quantifying the epidemiological transition

5. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

6. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

7. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

8. International survey of acute stroke imaging used to make revascularization treatment decisions.

9. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

10. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

11. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013.

12. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013:quantifying the epidemiological transition

13. Stroke: working toward a prioritized world agenda.

14. Stroke: working toward a prioritized world agenda.

15. Stroke: working toward a prioritized world agenda.

16. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

17. Stroke: working toward a prioritized world agenda.

18. Stroke: working toward a prioritized world agenda.

19. Stroke: working toward a prioritized world agenda.

20. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

21. Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality

22. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

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22 results on '"Bornstein, Natan M."'

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