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1. Longitudinal epidemiology of multiple sclerosis over 60 years in Newcastle, Australia: 1961 to 2021

Author

Simpson-Yap, S, Maltby, VE, Hall, S, Ward, S, Lea, R, Boggild, M, Kalincik, T, Shaw, C, Taylor, B, van der Walt, A, Lechner-Scott, J, Simpson-Yap, S, Maltby, VE, Hall, S, Ward, S, Lea, R, Boggild, M, Kalincik, T, Shaw, C, Taylor, B, van der Walt, A, and Lechner-Scott, J

Abstract

INTRODUCTION: Newcastle, Australia, has been serially studied for MS epidemiology since 1961, showing consistently increasing prevalence estimates and incidence rates, including to our 2011 study. OBJECTIVES: To assess the 2011-2021 epidemiology of MS in Newcastle and to compare with previous measures. METHODS: Demographic and clinical data were extracted from medical records of MS cases residing in Newcastle, as identified by public and private clinicians. Prevalence (2011 and 2021) and incidence rates (2011-2021, from onset and from diagnosis) and mortality rate (2011-2021) were estimated and age-standardised to the 2021 Australian population. RESULTS: The 2021 prevalence was 173.1/100,000 (age-standardised = 178.7/100,000, F/M-sex-ratio = 3.3), a 42.2 % increase from 2011 (F/M-sex-ratio = 3.1), 175.0 % from 1996 (F/M-sex-ratio = 2.6), and 831.0 % from 1961 (F/M-sex-ratio = 1.2). The 2011-21 age-standardised onset incidence rate was 3.5/100,000 person-years (F/M-sex-ratio = 2.8), a 68.7 % increase from 1971 to 81 (F/M-sex-ratio = 1.1) and 44.5 % from 1986 to 96 (F/M-sex-ratio = 2.3). The age-standardised diagnosis incidence rate was 6.1/100,000 (F/M-sex-ratio = 2.2), statistically unchanged from that in 2001-2011 (6.8/100,000, F/M-sex-ratio = 3.2). The 2011-21 mortality rate was 2.1/100,000 person-years (2.2 age-standardised, F/M-sex-ratio = 1.4), with a standardised mortality ratio of 1.6. CONCLUSION: The Newcastle region continues to be a high frequency zone for MS. The incidence rate from onset is significantly increased from previous estimates, but incidence rate from diagnosis is stable. Prevalence and incidence sex ratios have stabilised at roughly 3.0, similar to other Australian sites.

Published
2024

2. Diagnosis, differential diagnosis and misdiagnosis of Susac syndrome

Author

Triplett, JD, Qiu, J, O'Brien, B, Gopinath, S, Trewin, B, Spring, PJ, Shaffi, M, Ip, J, Chan, F, Chen, L, Wilson, I, Muller, C, Beadnall, HN, Boggild, M, Van der Walt, A, Roxburgh, R, Seery, N, Kalincik, T, Barnett, MH, Parratt, JDE, Reddel, SW, Tsang, B, Hardy, TA, Triplett, JD, Qiu, J, O'Brien, B, Gopinath, S, Trewin, B, Spring, PJ, Shaffi, M, Ip, J, Chan, F, Chen, L, Wilson, I, Muller, C, Beadnall, HN, Boggild, M, Van der Walt, A, Roxburgh, R, Seery, N, Kalincik, T, Barnett, MH, Parratt, JDE, Reddel, SW, Tsang, B, and Hardy, TA

Abstract

BACKGROUND AND PURPOSE: Susac syndrome (SuS) is an inflammatory condition of the brain, eye and ear. Diagnosis can be challenging, and misdiagnosis is common. METHODS: This is a retrospective review of the medical records of 32 adult patients from an Australasian cohort of SuS patients. RESULTS: An alternative diagnosis prior to SuS was made in 30 patients (94%) with seven patients receiving two or more diagnoses. The median time to diagnosis of SuS was 3 months (range 0.5-100 months). The commonest misdiagnoses were migraine in 10 patients (31%), cerebral vasculitis in six (19%), multiple sclerosis in five (16%) and stroke in five (16%). Twenty-two patients were treated for alternative diagnoses, 10 of whom had further clinical manifestations prior to SuS diagnosis. At presentation seven patients (22%) met criteria for definite SuS, 19 (59%) for probable SuS and six (19%) for possible SuS. Six patients (19%) presented with brain-eye-ear involvement, 14 with brain-ear (44%), six with brain-eye (19%) and six (19%) with only brain involvement. In patients with the complete triad of symptoms the median delay to diagnosis was 3 months (range 1-9 months) compared to 5.25 months (range 0.5-100 months) for patients with encephalopathy and ocular symptoms at presentation. CONCLUSIONS: Susac syndrome patients are frequently misdiagnosed at initial presentation, despite many having symptoms or radiological features that are red flags for the diagnosis. Delayed diagnosis can lead to patient morbidity. The varied ways in which SuS can present, and clinician failure to consider or recognize SuS, appear to be the main factors leading to misdiagnosis.

Published
2022

3. The role of social technologies in community care - A realist evaluation of a Danish web-based citizen-to-citizen platform adopted in community care to promote belonging and mental health

Author

Andersen, LMB, Reavley, NJ, Boggild, H, Overgaard, C, Andersen, LMB, Reavley, NJ, Boggild, H, and Overgaard, C

Abstract

As social technologies increase in popularity, there is a growing interest in incorporating them into mental health interventions. Research shows that the use of social technologies may support belonging and mental health. Findings, however, are contradictory and highlight the need to clarify the processes and mechanisms by which this technology may have positive effects. This study conducted a realist evaluation of a web-based citizen-to-citizen platform adopted within community care in a Danish Municipality. It focused on how, for whom and under what circumstances the web-based platform worked to promote belonging and mental health. The evaluation was structured in subsequent phases of development, testing, and refinement of programme theories. A purposeful sampling frame was developed based on the programme theories, and 27 interviews were conducted. With variations, the platform was found to support its users in meeting their social needs by (a) expanding their access to social networks; (b) allowing them to overcome barriers related to reaching out to new people in real life and (c) providing them with an improved starting point for identification of a relational match. Whether this resulted in improved belongingness and mental health was strongly affected by individual and relational circumstances. Findings suggest that web-based platforms that aim to enable citizens to locate friends and activity partners can serve as helpful tools in interventions striving to promote mental health in the community, as they may support people to fulfil a need for belongingness. However, the impact of such tools is highly dependent on the individual's abilities to use the initiatives to form relationships of sufficient quality to accommodate these needs. People with previous relational difficulties, and who have struggled to achieve feelings of belonging and citizens with limited digital literacy, may need support to realise the social opportunities provided by these technolog

Published
2022

4. Development of the First Tritiated Tetrazine : Facilitating Tritiation of Proteins

Author

Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, Herth, Matthias Manfred, Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, and Herth, Matthias Manfred

Abstract

Tetrazine (Tz)-trans-cyclooctene (TCO) ligation is an ultra-fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a H-3-Tz based synthon would have wide applications for in vitro/ex vivo assays. In this study, we developed a H-3-labeled Tz and characterized its potential for application to pretargeted autoradiography. Several strategies were explored to synthesize such a Tz. However, classical approaches such as reductive halogenation failed. For this reason, we designed a Tz containing an aldehyde and explored the possibility of reducing this group with NaBT4. This approach was successful and resulted in [H-3]-(4-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)methan-t-ol with a radiochemical yield of 22 %, a radiochemical purity of 96 % and a molar activity of 0.437 GBq/mu mol (11.8 Ci/mmol). The compound was successfully applied to pretargeted autoradiography. Thus, we report the synthesis of the first H-3-labeled Tz and its successful application as a labeling building block.

Published
2022
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5. Development of the First Tritiated Tetrazine : Facilitating Tritiation of Proteins

Author

Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, Herth, Matthias Manfred, Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, and Herth, Matthias Manfred

Abstract

Tetrazine (Tz)-trans-cyclooctene (TCO) ligation is an ultra-fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a H-3-Tz based synthon would have wide applications for in vitro/ex vivo assays. In this study, we developed a H-3-labeled Tz and characterized its potential for application to pretargeted autoradiography. Several strategies were explored to synthesize such a Tz. However, classical approaches such as reductive halogenation failed. For this reason, we designed a Tz containing an aldehyde and explored the possibility of reducing this group with NaBT4. This approach was successful and resulted in [H-3]-(4-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)methan-t-ol with a radiochemical yield of 22 %, a radiochemical purity of 96 % and a molar activity of 0.437 GBq/mu mol (11.8 Ci/mmol). The compound was successfully applied to pretargeted autoradiography. Thus, we report the synthesis of the first H-3-labeled Tz and its successful application as a labeling building block.

Published
2022
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6. Development of the First Tritiated Tetrazine : Facilitating Tritiation of Proteins

Author

Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, Herth, Matthias Manfred, Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, and Herth, Matthias Manfred

Abstract

Tetrazine (Tz)-trans-cyclooctene (TCO) ligation is an ultra-fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a H-3-Tz based synthon would have wide applications for in vitro/ex vivo assays. In this study, we developed a H-3-labeled Tz and characterized its potential for application to pretargeted autoradiography. Several strategies were explored to synthesize such a Tz. However, classical approaches such as reductive halogenation failed. For this reason, we designed a Tz containing an aldehyde and explored the possibility of reducing this group with NaBT4. This approach was successful and resulted in [H-3]-(4-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)methan-t-ol with a radiochemical yield of 22 %, a radiochemical purity of 96 % and a molar activity of 0.437 GBq/mu mol (11.8 Ci/mmol). The compound was successfully applied to pretargeted autoradiography. Thus, we report the synthesis of the first H-3-labeled Tz and its successful application as a labeling building block.

Published
2022
Full Text
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7. Development of the First Tritiated Tetrazine : Facilitating Tritiation of Proteins

Author

Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, Herth, Matthias Manfred, Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, and Herth, Matthias Manfred

Abstract

Tetrazine (Tz)-trans-cyclooctene (TCO) ligation is an ultra-fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a H-3-Tz based synthon would have wide applications for in vitro/ex vivo assays. In this study, we developed a H-3-labeled Tz and characterized its potential for application to pretargeted autoradiography. Several strategies were explored to synthesize such a Tz. However, classical approaches such as reductive halogenation failed. For this reason, we designed a Tz containing an aldehyde and explored the possibility of reducing this group with NaBT4. This approach was successful and resulted in [H-3]-(4-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)methan-t-ol with a radiochemical yield of 22 %, a radiochemical purity of 96 % and a molar activity of 0.437 GBq/mu mol (11.8 Ci/mmol). The compound was successfully applied to pretargeted autoradiography. Thus, we report the synthesis of the first H-3-labeled Tz and its successful application as a labeling building block.

Published
2022
Full Text
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8. Development of the First Tritiated Tetrazine : Facilitating Tritiation of Proteins

Author

Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, Herth, Matthias Manfred, Bidesi, Natasha Shalina Radjani, Battisti, Umberto Maria, van de Broek, Sara Lopes, Shalgunov, Vladimir, Dall, Anne-Mette, Kristensen, Jesper Boggild, Sehlin, Dag, Syvänen, Stina, Knudsen, Gitte Moos, and Herth, Matthias Manfred

Abstract

Tetrazine (Tz)-trans-cyclooctene (TCO) ligation is an ultra-fast and highly selective reaction and it is particularly suited to label biomolecules under physiological conditions. As such, a H-3-Tz based synthon would have wide applications for in vitro/ex vivo assays. In this study, we developed a H-3-labeled Tz and characterized its potential for application to pretargeted autoradiography. Several strategies were explored to synthesize such a Tz. However, classical approaches such as reductive halogenation failed. For this reason, we designed a Tz containing an aldehyde and explored the possibility of reducing this group with NaBT4. This approach was successful and resulted in [H-3]-(4-(6-(pyridin-2-yl)-1,2,4,5-tetrazin-3-yl)phenyl)methan-t-ol with a radiochemical yield of 22 %, a radiochemical purity of 96 % and a molar activity of 0.437 GBq/mu mol (11.8 Ci/mmol). The compound was successfully applied to pretargeted autoradiography. Thus, we report the synthesis of the first H-3-labeled Tz and its successful application as a labeling building block.

Published
2022
Full Text
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9. 'Like a rainy weather inside of me':Qualitative content analysis of telephone consultations concerning back pain preceding out-of-hospital cardiac arrest

Author

Jensen, Britta, Vardinghus-Nielsen, Henrik, Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Gnesin, Filip, Zylyftari, Nertila, Kragholm, Kristian, Folke, Fredrik, Christensen, Helle Collatz, Blomberg, Stig Nikolaj, Torp-Pedersen, Christian, Boggild, Henrik, Jensen, Britta, Vardinghus-Nielsen, Henrik, Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Gnesin, Filip, Zylyftari, Nertila, Kragholm, Kristian, Folke, Fredrik, Christensen, Helle Collatz, Blomberg, Stig Nikolaj, Torp-Pedersen, Christian, and Boggild, Henrik

Abstract

Introduction: Cardiac arrest patients presenting with back pain are at risk of not receiving the appropriate help when calling emergency medical services. In telephone consultations regarding patients with back pain pre-ceding an out-of-hospital cardiac arrest, we investigated how communication between caller and call-taker influenced the call-taker's interpretation of back pain descriptions and decision-making about choice of response.Method: The study was conducted using 20 recorded phone calls from 17 patients who contacted the Copenhagen Emergency Medical Services (Denmark) reporting back pain up to 24 hours before an out-of-hospital cardiac arrest. Qualitative content analysis was applied.Results: Two main categories emerged: (1) reasons, including subcategories: reported conditions, descriptions of conditions, patient's interpretation of condition and patient's own remedial actions; and (2) considerations, including subcategories: assessment of the severity, call-taker's interpretation of the condition, arguments for chosen response and conditions not facilitating further communication by the call-taker.Conclusion: In telephone consultations regarding patients with back pain preceding an out-of-hospital cardiac arrest the communication was influenced by the communicative preconditions of the call-taker. Communication in consultations where ambulances were not dispatched was characterized by complex descriptions of symptoms not easily fitting into the health system's interpretations of conditions warranting an urgent response.

Published
2022

10. 'Like a rainy weather inside of me':Qualitative content analysis of telephone consultations concerning back pain preceding out-of-hospital cardiac arrest

Author

Jensen, Britta, Vardinghus-Nielsen, Henrik, Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Gnesin, Filip, Zylyftari, Nertila, Kragholm, Kristian, Folke, Fredrik, Christensen, Helle Collatz, Blomberg, Stig Nikolaj, Torp-Pedersen, Christian, Boggild, Henrik, Jensen, Britta, Vardinghus-Nielsen, Henrik, Mills, Elisabeth Helen Anna, Møller, Amalie Lykkemark, Gnesin, Filip, Zylyftari, Nertila, Kragholm, Kristian, Folke, Fredrik, Christensen, Helle Collatz, Blomberg, Stig Nikolaj, Torp-Pedersen, Christian, and Boggild, Henrik

Abstract

Introduction: Cardiac arrest patients presenting with back pain are at risk of not receiving the appropriate help when calling emergency medical services. In telephone consultations regarding patients with back pain pre-ceding an out-of-hospital cardiac arrest, we investigated how communication between caller and call-taker influenced the call-taker's interpretation of back pain descriptions and decision-making about choice of response.Method: The study was conducted using 20 recorded phone calls from 17 patients who contacted the Copenhagen Emergency Medical Services (Denmark) reporting back pain up to 24 hours before an out-of-hospital cardiac arrest. Qualitative content analysis was applied.Results: Two main categories emerged: (1) reasons, including subcategories: reported conditions, descriptions of conditions, patient's interpretation of condition and patient's own remedial actions; and (2) considerations, including subcategories: assessment of the severity, call-taker's interpretation of the condition, arguments for chosen response and conditions not facilitating further communication by the call-taker.Conclusion: In telephone consultations regarding patients with back pain preceding an out-of-hospital cardiac arrest the communication was influenced by the communicative preconditions of the call-taker. Communication in consultations where ambulances were not dispatched was characterized by complex descriptions of symptoms not easily fitting into the health system's interpretations of conditions warranting an urgent response.

Published
2022

11. NMOSD and MS prevalence in the Indigenous populations of Australia and New Zealand

Author

Bukhari, W., Khalilidehkordi, E., Mason, D.F., Barnett, M.H., Taylor, B.V., Fabis-Pedrini, M., Kermode, A.G., Subramanian, S., Waters, P., Broadley, S.A., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brilot, F., Brownlee, W.J., Bundell, C.S., Butzkueven, H., Carroll, W.M., Chen, C., Clarke, L., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez Sanchez, S., Kilpatrick, T.J., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M-W, Lynch, C., Macdonell, R.A.L., Marriott, M.P., McCombe, P.A., O’Gorman, C., Parratt, J.D.E., Pender, M.P., Pereira, J., Pollard, J.D., Prain, K.M., Ramanathan, S., Reddell, S.W., Shaw, C., Silvestrini, R.A., Slee, M., Spies, J., Stankovich, J., Sutton, I., Vincent, A., Vucic, S., Walsh, M., Willoughby, E., Wong, R.C., Woodhall, M., Yiu, E.M., Bukhari, W., Khalilidehkordi, E., Mason, D.F., Barnett, M.H., Taylor, B.V., Fabis-Pedrini, M., Kermode, A.G., Subramanian, S., Waters, P., Broadley, S.A., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brilot, F., Brownlee, W.J., Bundell, C.S., Butzkueven, H., Carroll, W.M., Chen, C., Clarke, L., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez Sanchez, S., Kilpatrick, T.J., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M-W, Lynch, C., Macdonell, R.A.L., Marriott, M.P., McCombe, P.A., O’Gorman, C., Parratt, J.D.E., Pender, M.P., Pereira, J., Pollard, J.D., Prain, K.M., Ramanathan, S., Reddell, S.W., Shaw, C., Silvestrini, R.A., Slee, M., Spies, J., Stankovich, J., Sutton, I., Vincent, A., Vucic, S., Walsh, M., Willoughby, E., Wong, R.C., Woodhall, M., and Yiu, E.M.

Abstract

Background We studied the prevalence of neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Indigenous populations of Australia and New Zealand with the aim of assessing potential differences. Methods Cases of possible NMOSD and MS were collected from Australia and New Zealand. Clinical details, MR imaging, and serologic results were used to apply 2015 IPND diagnostic criteria for NMOSD and 2010 McDonald criteria for MS. Frequencies of self-determined ethnic ancestry were calculated for confirmed NMOSD, suspected NMOSD, and MS. Prevalence rates for NMOSD and MS according to ancestry were compared. Results There were 75 cases with NMOSD, 89 with suspected NMSOD, and 101 with MS. NMOSD cases were more likely to have Asian, Indigenous, or Other ancestry compared to suspected NMOSD or MS. There were no differences in the clinical phenotype of NMOSD seen in Indigenous compared to European ancestry populations. Per 100,000, the prevalence estimate for NMOSD in people with Māori ancestry was 1.50 (95% CI 0.52–2.49) which was similar to those with Asian ancestry 1.57 (95% CI 1.15–1.98). NMOSD prevalence in Australian Aboriginal and Torres Strait Islander populations was 0.38 (95% CI 0.00–0.80) per 100,000. Conclusion The prevalence of NMOSD in the Māori population is similar to South East Asian countries, reflecting their historical origins. The prevalence of MS in this group is intermediate between those with South East Asian and European ancestry living in New Zealand. Both NMOSD and particularly MS appear to be uncommon in the Indigenous populations of Australia.

Published
2021

12. MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis

Author

Clarke, L, Arnett, S, Bukhari, W, Khalilidehkordi, E, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, DA, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, MW, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, Cameron, Spies, JM, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AGK, Marriott, MP, Parratt, JDE, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, Broadley, SA, Clarke, L, Arnett, S, Bukhari, W, Khalilidehkordi, E, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, DA, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, MW, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, Cameron, Spies, JM, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AGK, Marriott, MP, Parratt, JDE, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, and Broadley, SA

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), “bright spotty” (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS

Published
2021

14. MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis

Author

Clarke, L, Arnett, S, Bukhari, W, Khalilidehkordi, E, Sanchez, SJ, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, DA, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, M-W, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, CP, Spies, JM, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AGK, Marriott, MP, Parratt, JDE, Slee, M, Taylor, B, Willoughby, E, Brilot, F, Vincent, A, Waters, P, Broadley, SA, Clarke, L, Arnett, S, Bukhari, W, Khalilidehkordi, E, Sanchez, SJ, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, DA, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, M-W, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, CP, Spies, JM, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AGK, Marriott, MP, Parratt, JDE, Slee, M, Taylor, B, Willoughby, E, Brilot, F, Vincent, A, Waters, P, and Broadley, SA

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed predictive models to distinguish the two conditions. NMOSD and MS MRI lesions were identified and defined through a literature search. Aquaporin-4 (AQP4) antibody positive NMOSD cases and age- and sex-matched MS cases were collected. MRI of orbits, brain and spine were reported by at least two blinded reviewers. MRI brain or spine was available for 166/168 (99%) of cases. Longitudinally extensive (OR = 203), "bright spotty" (OR = 93.8), whole (axial; OR = 57.8) or gadolinium (Gd) enhancing (OR = 28.6) spinal cord lesions, bilateral (OR = 31.3) or Gd-enhancing (OR = 15.4) optic nerve lesions, and nucleus tractus solitarius (OR = 19.2), periaqueductal (OR = 16.8) or hypothalamic (OR = 7.2) brain lesions were associated with NMOSD. Ovoid (OR = 0.029), Dawson's fingers (OR = 0.031), pyramidal corpus callosum (OR = 0.058), periventricular (OR = 0.136), temporal lobe (OR = 0.137) and T1 black holes (OR = 0.154) brain lesions were associated with MS. A score-based algorithm and a decision tree determined by machine learning accurately predicted more than 85% of both diagnoses using first available imaging alone. We have confirmed NMOSD and MS specific MRI features and combined these in predictive models that can accurately identify more than 85% of cases as either AQP4 seropositive NMOSD or MS.

Published
2021

15. NMOSD and MS prevalence in the Indigenous populations of Australia and New Zealand

Author

Bukhari, W., Khalilidehkordi, E., Mason, D.F., Barnett, M.H., Taylor, B.V., Fabis-Pedrini, M., Kermode, A.G., Subramanian, S., Waters, P., Broadley, S.A., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brilot, F., Brownlee, W.J., Bundell, C.S., Butzkueven, H., Carroll, W.M., Chen, C., Clarke, L., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez Sanchez, S., Kilpatrick, T.J., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M-W, Lynch, C., Macdonell, R.A.L., Marriott, M.P., McCombe, P.A., O’Gorman, C., Parratt, J.D.E., Pender, M.P., Pereira, J., Pollard, J.D., Prain, K.M., Ramanathan, S., Reddell, S.W., Shaw, C., Silvestrini, R.A., Slee, M., Spies, J., Stankovich, J., Sutton, I., Vincent, A., Vucic, S., Walsh, M., Willoughby, E., Wong, R.C., Woodhall, M., Yiu, E.M., Bukhari, W., Khalilidehkordi, E., Mason, D.F., Barnett, M.H., Taylor, B.V., Fabis-Pedrini, M., Kermode, A.G., Subramanian, S., Waters, P., Broadley, S.A., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brilot, F., Brownlee, W.J., Bundell, C.S., Butzkueven, H., Carroll, W.M., Chen, C., Clarke, L., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez Sanchez, S., Kilpatrick, T.J., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M-W, Lynch, C., Macdonell, R.A.L., Marriott, M.P., McCombe, P.A., O’Gorman, C., Parratt, J.D.E., Pender, M.P., Pereira, J., Pollard, J.D., Prain, K.M., Ramanathan, S., Reddell, S.W., Shaw, C., Silvestrini, R.A., Slee, M., Spies, J., Stankovich, J., Sutton, I., Vincent, A., Vucic, S., Walsh, M., Willoughby, E., Wong, R.C., Woodhall, M., and Yiu, E.M.

Abstract

Background We studied the prevalence of neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Indigenous populations of Australia and New Zealand with the aim of assessing potential differences. Methods Cases of possible NMOSD and MS were collected from Australia and New Zealand. Clinical details, MR imaging, and serologic results were used to apply 2015 IPND diagnostic criteria for NMOSD and 2010 McDonald criteria for MS. Frequencies of self-determined ethnic ancestry were calculated for confirmed NMOSD, suspected NMOSD, and MS. Prevalence rates for NMOSD and MS according to ancestry were compared. Results There were 75 cases with NMOSD, 89 with suspected NMSOD, and 101 with MS. NMOSD cases were more likely to have Asian, Indigenous, or Other ancestry compared to suspected NMOSD or MS. There were no differences in the clinical phenotype of NMOSD seen in Indigenous compared to European ancestry populations. Per 100,000, the prevalence estimate for NMOSD in people with Māori ancestry was 1.50 (95% CI 0.52–2.49) which was similar to those with Asian ancestry 1.57 (95% CI 1.15–1.98). NMOSD prevalence in Australian Aboriginal and Torres Strait Islander populations was 0.38 (95% CI 0.00–0.80) per 100,000. Conclusion The prevalence of NMOSD in the Māori population is similar to South East Asian countries, reflecting their historical origins. The prevalence of MS in this group is intermediate between those with South East Asian and European ancestry living in New Zealand. Both NMOSD and particularly MS appear to be uncommon in the Indigenous populations of Australia.

Published
2021

16. Multinomial, Poisson and Gaussian statistics in count data analysis

Author

Lass, Jakob, Boggild, Magnus Egede, Hedegard, Per, Lefmann, Kim, Lass, Jakob, Boggild, Magnus Egede, Hedegard, Per, and Lefmann, Kim

Abstract

It is generally known that counting statistics is not correctly described by a Gaussian approximation. Nevertheless, in neutron scattering, it is common practice to apply this approximation to the counting statistics; also at low counting numbers. We show that the application of this approximation leads to skewed results not only for low-count features, such as background level estimation, but also for its estimation at double-digit count numbers. In effect, this approximation is shown to be imprecise on all levels of count. Instead, a Multinomial approach is introduced as well as a more standard Poisson method, which we compare with the Gaussian case. These two methods originate from a proper analysis of a multi-detector setup and a standard triple axis instrument.We devise a simple mathematical procedure to produce unbiased fits using the Multinomial distribution and demonstrate this method on synthetic and actual inelastic scattering data. We find that the Multinomial method provide almost unbiased results, and in some cases outperforms the Poisson statistics. Although significantly biased, the Gaussian approach is in general more robust in cases where the fitted model is not a true representation of reality. For this reason, a proper data analysis toolbox for low-count neutron scattering should therefore contain more than one model for counting statistics.

Published
2021

17. Unraveling the electronic properties of graphene with substitutional oxygen

Author

Mackenzie, David M. A., Galbiati, Miriam, de Cerio, Xabier D., Sahalianov, Ihor, Radchenko, Taras M., Sun, Jianbo, Pena, Diego, Gammelgaard, Lene, Jessen, Bjarke S., Thomsen, Joachim D., Boggild, Peter, Garcia-Lekue, Aran, Camilli, Luca, Caridad, Jose M., Mackenzie, David M. A., Galbiati, Miriam, de Cerio, Xabier D., Sahalianov, Ihor, Radchenko, Taras M., Sun, Jianbo, Pena, Diego, Gammelgaard, Lene, Jessen, Bjarke S., Thomsen, Joachim D., Boggild, Peter, Garcia-Lekue, Aran, Camilli, Luca, and Caridad, Jose M.

Abstract

We show abrupt changes in the electronic properties of graphene with different types of binding to oxygen. Whereas oxygen bonded to the basal plane in the form of functional groups p-type dopes graphene, we prove that substitutional (i.e. in-plane) oxygen n-type dopes it. Moreover, we determine that impurity scattering potentials introduced by these substitutional atoms are notably larger than those of conventional donors, e.g. nitrogen. Both facts ultimately result in a conduction asymmetry in the system with holes being scattered more strongly than electrons. These findings provide essential insights into the impact of oxygen in carbon nanomaterials such as graphene oxide, oxidized carbon nanotubes or novel two-dimensional pi-conjugated organic frameworks, promising compounds for a wide range of applications including flexible electronics, catalysis, energy storage or biomedicine., Funding Agencies|Danish National Research FoundationDanmarks Grundforskningsfond [DNRF103]; EU Graphene Flagship Core 2 [785219]; EU Graphene Flagship Core 3 [785219]; Villum Young Investigator Program [19130]; Programma per Giovani Ricercatori-Rita Levi Montalcini 2017; NAS of Ukraine [0120U102265]; Provincial Council of Gipuzkoa [2021-CIEN-000070-01]; Basque Department of Education [PIBA-2020-1-0014]; VinnovaVinnova [201902878]; Spanish Ministry of Science and InnovationSpanish Government [PID2019-107338RB-C66]; European Union (EU) through Horizon 2020 (FET-Open project SPRING Grant) [863098]; MICINN Ramon y Cajal program [RYC2019-028443-I]

Published
2021
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18. Fermi velocity renormalization in graphene probed by terahertz time-domain spectroscopy

Author

Whelan, Patrick R., Shen, Qian, Zhou, Binbin, Serrano, Ismael G., Kamalakar, M. Venkata, Mackenzie, David M. A., Ji, Jie, Huang, Deping, Shi, Haofei, Luo, Da, Wang, Meihui, Ruoff, Rodney S., Jauho, Antti-Pekka, Jepsen, Peter U., Boggild, Peter, Caridad, Jose M., Whelan, Patrick R., Shen, Qian, Zhou, Binbin, Serrano, Ismael G., Kamalakar, M. Venkata, Mackenzie, David M. A., Ji, Jie, Huang, Deping, Shi, Haofei, Luo, Da, Wang, Meihui, Ruoff, Rodney S., Jauho, Antti-Pekka, Jepsen, Peter U., Boggild, Peter, and Caridad, Jose M.

Abstract

We demonstrate terahertz time-domain spectroscopy (THz-TDS) to be an accurate, rapid and scalable method to probe the interaction-induced Fermi velocity renormalization nu F*10(12) cm(-2), Fermi level > 0.1 eV). From an application point of view, the ability to rapidly and non-destructively quantify and map the electrical (sigma(DC), n, mu) and electronic ( nu F*

Published
2020
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19. Production and processing of graphene and related materials

Author

Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., Garcia-Hernandez, Mar, Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., and Garcia-Hernandez, Mar

Abstract

We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a hands-on approach, providing practical details and procedures as derived from literature as well as from the authors experience, in order to enable the reader to reproduce the results. Section I is devoted to bottom up approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers top down techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers and modified Hummers methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aeroge, Funding Agencies|European Commission Graphene Flagship Core1 [696656, 785219]

Published
2020
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20. Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Author

Khalilidehkordi, E, Clarke, L, Arnett, S, Bukhari, W, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, MW, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AG, Marriott, MP, Parratt, J, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, Broadley, SA, Khalilidehkordi, E, Clarke, L, Arnett, S, Bukhari, W, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, MW, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AG, Marriott, MP, Parratt, J, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, and Broadley, SA

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.

Published
2020

21. Mass wasting on Alpha Ridge in the Arctic Ocean: new insights from multibeam bathymetry and sub-bottom profiler data

Author

Boggild, Kai, Mosher, David C., Travaglini, Paola, Gebhardt, Catalina, Mayer, Larry, Boggild, Kai, Mosher, David C., Travaglini, Paola, Gebhardt, Catalina, and Mayer, Larry

Abstract

Marine geological and geophysical data from Alpha Ridge in the Arctic Ocean are sparse because of thick perennial sea-ice cover, which prevents access by most surface vessels. Rare seismic data in this area, acquired largely from drifting ice-camps, had shown the hemipelagic drape that covers most of the ridge is highly disrupted within a large (>90 000 km2) south central region. Here, evidence of pronounced seafloor erosion and debris flows infilling seafloor lows was previously interpreted to be the result of a possible bolide impact. In recent years, several icebreaker expeditions have successfully acquired multibeam bathymetry and sub-bottom profiler data in the western segment of this region. Analysis of these data reveals a complex seafloor morphology characterized by ridges and troughs, angular blocks and escarpments as well as seismic facies characterized by hyperbolic seafloor reflections, and convoluted to incoherent and transparent sub-bottom reflectivity. These features are interpreted as evidence of sediment mass movement with varying degrees of lateral transport deformation. At least two episodes of failure are interpreted based on the presence of both buried and surficial mass-transport features. As multiple events are interpreted, seismicity is the most plausible trigger mechanism rather than bolide impact.

Published
2020

22. Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Author

Khalilidehkordi, Elham, Clarke, Laura, Arnett, Simon, Bukhari, Wajih, Jimenez Sanchez, Sofia, O'Gorman, Cullen, Sun, Jing, Prain, Kerri M., Woodhall, Mark, Silvestrini, Roger, Bundell, Christine S., Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brown, Matthew, Brownlee, Wallace, Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P.D., Heshmat, Saman, Hodgkinson, Suzanne, Kilpatrick, Trevor J., King, John, Kneebone, Chris, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming Wei, Lynch, Christopher, Macdonell, Richard A.L., Mason, Deborah F., McCombe, Pamela A., Pereira, Jennifer, Pollard, John D., Ramanathan, Sudarshini, Reddel, Stephen W., Shaw, Cameron, Spies, Judith, Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G., Marriott, Mark P., Parratt, John, Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Brilot, Fabienne, Vincent, Angela, Waters, Patrick, Broadley, Simon A., Khalilidehkordi, Elham, Clarke, Laura, Arnett, Simon, Bukhari, Wajih, Jimenez Sanchez, Sofia, O'Gorman, Cullen, Sun, Jing, Prain, Kerri M., Woodhall, Mark, Silvestrini, Roger, Bundell, Christine S., Abernethy, David, Bhuta, Sandeep, Blum, Stefan, Boggild, Mike, Boundy, Karyn, Brew, Bruce J., Brown, Matthew, Brownlee, Wallace, Butzkueven, Helmut, Carroll, William M., Chen, Celia, Coulthard, Alan, Dale, Russell C., Das, Chandi, Fabis-Pedrini, Marzena J., Fulcher, David, Gillis, David, Hawke, Simon, Heard, Robert, Henderson, Andrew P.D., Heshmat, Saman, Hodgkinson, Suzanne, Kilpatrick, Trevor J., King, John, Kneebone, Chris, Kornberg, Andrew J., Lechner-Scott, Jeannette, Lin, Ming Wei, Lynch, Christopher, Macdonell, Richard A.L., Mason, Deborah F., McCombe, Pamela A., Pereira, Jennifer, Pollard, John D., Ramanathan, Sudarshini, Reddel, Stephen W., Shaw, Cameron, Spies, Judith, Stankovich, James, Sutton, Ian, Vucic, Steve, Walsh, Michael, Wong, Richard C., Yiu, Eppie M., Barnett, Michael H., Kermode, Allan G., Marriott, Mark P., Parratt, John, Slee, Mark, Taylor, Bruce V., Willoughby, Ernest, Brilot, Fabienne, Vincent, Angela, Waters, Patrick, and Broadley, Simon A.

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.

Published
2020

23. Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Author

Khalilidehkordi, E, Clarke, L, Arnett, S, Bukhari, W, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, M-W, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AG, Marriott, MP, Parratt, J, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, Broadley, SA, Khalilidehkordi, E, Clarke, L, Arnett, S, Bukhari, W, Jimenez Sanchez, S, O'Gorman, C, Sun, J, Prain, KM, Woodhall, M, Silvestrini, R, Bundell, CS, Abernethy, D, Bhuta, S, Blum, S, Boggild, M, Boundy, K, Brew, BJ, Brown, M, Brownlee, W, Butzkueven, H, Carroll, WM, Chen, C, Coulthard, A, Dale, RC, Das, C, Fabis-Pedrini, MJ, Fulcher, D, Gillis, D, Hawke, S, Heard, R, Henderson, APD, Heshmat, S, Hodgkinson, S, Kilpatrick, TJ, King, J, Kneebone, C, Kornberg, AJ, Lechner-Scott, J, Lin, M-W, Lynch, C, Macdonell, RAL, Mason, DF, McCombe, PA, Pereira, J, Pollard, JD, Ramanathan, S, Reddel, SW, Shaw, C, Spies, J, Stankovich, J, Sutton, I, Vucic, S, Walsh, M, Wong, RC, Yiu, EM, Barnett, MH, Kermode, AG, Marriott, MP, Parratt, J, Slee, M, Taylor, BV, Willoughby, E, Brilot, F, Vincent, A, Waters, P, and Broadley, SA

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.

Published
2020

24. Mass wasting on Alpha Ridge in the Arctic Ocean: new insights from multibeam bathymetry and sub-bottom profiler data

Author

Boggild, Kai, Mosher, David C., Travaglini, Paola, Gebhardt, Catalina, Mayer, Larry, Boggild, Kai, Mosher, David C., Travaglini, Paola, Gebhardt, Catalina, and Mayer, Larry

Abstract

Marine geological and geophysical data from Alpha Ridge in the Arctic Ocean are sparse because of thick perennial sea-ice cover, which prevents access by most surface vessels. Rare seismic data in this area, acquired largely from drifting ice-camps, had shown the hemipelagic drape that covers most of the ridge is highly disrupted within a large (>90 000 km2) south central region. Here, evidence of pronounced seafloor erosion and debris flows infilling seafloor lows was previously interpreted to be the result of a possible bolide impact. In recent years, several icebreaker expeditions have successfully acquired multibeam bathymetry and sub-bottom profiler data in the western segment of this region. Analysis of these data reveals a complex seafloor morphology characterized by ridges and troughs, angular blocks and escarpments as well as seismic facies characterized by hyperbolic seafloor reflections, and convoluted to incoherent and transparent sub-bottom reflectivity. These features are interpreted as evidence of sediment mass movement with varying degrees of lateral transport deformation. At least two episodes of failure are interpreted based on the presence of both buried and surficial mass-transport features. As multiple events are interpreted, seismicity is the most plausible trigger mechanism rather than bolide impact.

Published
2020

25. Production and processing of graphene and related materials

Author

Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., Garcia-Hernandez, Mar, Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., and Garcia-Hernandez, Mar

Abstract

We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a hands-on approach, providing practical details and procedures as derived from literature as well as from the authors experience, in order to enable the reader to reproduce the results. Section I is devoted to bottom up approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers top down techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers and modified Hummers methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aeroge, Funding Agencies|European Commission Graphene Flagship Core1 [696656, 785219]

Published
2020
Full Text
View/download PDF

26. Production and processing of graphene and related materials

Author

Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., Garcia-Hernandez, Mar, Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., and Garcia-Hernandez, Mar

Abstract

We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a hands-on approach, providing practical details and procedures as derived from literature as well as from the authors experience, in order to enable the reader to reproduce the results. Section I is devoted to bottom up approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers top down techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers and modified Hummers methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aeroge, Funding Agencies|European Commission Graphene Flagship Core1 [696656, 785219]

Published
2020
Full Text
View/download PDF

27. Production and processing of graphene and related materials

Author

Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., Garcia-Hernandez, Mar, Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., and Garcia-Hernandez, Mar

Abstract

We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a hands-on approach, providing practical details and procedures as derived from literature as well as from the authors experience, in order to enable the reader to reproduce the results. Section I is devoted to bottom up approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers top down techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers and modified Hummers methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aeroge, Funding Agencies|European Commission Graphene Flagship Core1 [696656, 785219]

Published
2020
Full Text
View/download PDF

28. Production and processing of graphene and related materials

Author

Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., Garcia-Hernandez, Mar, Backes, Claudia, Abdelkader, Amr M., Alonso, Concepcion, Andrieux-Ledier, Amandine, Arenal, Raul, Azpeitia, Jon, Balakrishnan, Nilanthy, Banszerus, Luca, Barjon, Julien, Bartali, Ruben, Bellani, Sebastiano, Berger, Claire, Berger, Reinhard, Ortega, M. M. Bernal, Bernard, Carlo, Beton, Peter H., Beyer, Andre, Bianco, Alberto, Boggild, Peter, Bonaccorso, Francesco, Barin, Gabriela Borin, Botas, Cristina, Bueno, Rebeca A., Carriazo, Daniel, Castellanos-Gomez, Andres, Christian, Meganne, Ciesielski, Artur, Ciuk, Tymoteusz, Cole, Matthew T., Coleman, Jonathan, Coletti, Camilla, Crema, Luigi, Cun, Huanyao, Dasler, Daniela, De Fazio, Domenico, Diez, Noel, Drieschner, Simon, Duesberg, Georg S., Fasel, Roman, Feng, Xinliang, Fina, Alberto, Forti, Stiven, Galiotis, Costas, Garberoglio, Giovanni, Garcia, Jorge M., Antonio Garrido, Jose, Gibertini, Marco, Goelzhaeuser, Armin, Gomez, Julio, Greber, Thomas, Hauke, Frank, Hemmi, Adrian, Hernandez-Rodriguez, Irene, Hirsch, Andreas, Hodge, Stephen A., Huttel, Yves, Jepsen, Peter U., Jimenez, Ignacio, Kaiser, Ute, Kaplas, Tommi, Kim, HoKwon, Kis, Andras, Papagelis, Konstantinos, Kostarelos, Kostas, Krajewska, Aleksandra, Lee, Kangho, Li, Changfeng, Lipsanen, Harri, Liscio, Andrea, Lohe, Martin R., Loiseau, Annick, Lombardi, Lucia, Francisca Lopez, Maria, Martin, Oliver, Martin, Cristina, Martinez, Lidia, Angel Martin-Gago, Jose, Ignacio Martinez, Jose, Marzari, Nicola, Mayoral, Alvaro, McManus, John, Melucci, Manuela, Mendez, Javier, Merino, Cesar, Merino, Pablo, Meyer, Andreas P., Miniussi, Elisa, Miseikis, Vaidotas, Mishra, Neeraj, Morandi, Vittorio, Munuera, Carmen, Munoz, Roberto, Nolan, Hugo, Ortolani, Luca, Ott, Anna K., Palacio, Irene, Palermo, Vincenzo, Parthenios, John, Pasternak, Iwona, Patane, Amalia, Prato, Maurizio, Prevost, Henri, Prudkovskiy, Vladimir, Pugno, Nicola, Rojo, Teofilo, Rossi, Antonio, Ruffieux, Pascal, Samori, Paolo, Schue, Leonard, Setijadi, Eki, Seyller, Thomas, Speranza, Giorgio, Stampfer, Christoph, Stenger, Ingrid, Strupinski, Wlodek, Svirko, Yuri, Taioli, Simone, Teo, Kenneth B. K., Testi, Matteo, Tomarchio, Flavia, Tortello, Mauro, Treossi, Emanuele, Turchanin, Andrey, Vazquez, Ester, Villaro, Elvira, Whelan, Patrick R., Xia, Zhenyuan, Yakimova, Rositsa, Yang, Sheng, Yazdi, Gholamreza, Yim, Chanyoung, Yoon, Duhee, Zhang, Xianghui, Zhuang, Xiaodong, Colombo, Luigi, Ferrari, Andrea C., and Garcia-Hernandez, Mar

Abstract

We present an overview of the main techniques for production and processing of graphene and related materials (GRMs), as well as the key characterization procedures. We adopt a hands-on approach, providing practical details and procedures as derived from literature as well as from the authors experience, in order to enable the reader to reproduce the results. Section I is devoted to bottom up approaches, whereby individual constituents are pieced together into more complex structures. We consider graphene nanoribbons (GNRs) produced either by solution processing or by on-surface synthesis in ultra high vacuum (UHV), as well carbon nanomembranes (CNM). Production of a variety of GNRs with tailored band gaps and edge shapes is now possible. CNMs can be tuned in terms of porosity, crystallinity and electronic behaviour. Section II covers top down techniques. These rely on breaking down of a layered precursor, in the graphene case usually natural crystals like graphite or artificially synthesized materials, such as highly oriented pyrolythic graphite, monolayers or few layers (FL) flakes. The main focus of this section is on various exfoliation techniques in a liquid media, either intercalation or liquid phase exfoliation (LPE). The choice of precursor, exfoliation method, medium as well as the control of parameters such as time or temperature are crucial. A definite choice of parameters and conditions yields a particular material with specific properties that makes it more suitable for a targeted application. We cover protocols for the graphitic precursors to graphene oxide (GO). This is an important material for a range of applications in biomedicine, energy storage, nanocomposites, etc. Hummers and modified Hummers methods are used to make GO that subsequently can be reduced to obtain reduced graphene oxide (RGO) with a variety of strategies. GO flakes are also employed to prepare three-dimensional (3d) low density structures, such as sponges, foams, hydro- or aeroge, Funding Agencies|European Commission Graphene Flagship Core1 [696656, 785219]

Published
2020
Full Text
View/download PDF

29. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gadin, Katja Gillander, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gadin, Katja Gillander

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
Full Text
View/download PDF

30. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gillander Gådin, Katja, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gillander Gådin, Katja

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
Full Text
View/download PDF

31. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gillander Gådin, Katja, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gillander Gådin, Katja

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
Full Text
View/download PDF

32. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gadin, Katja Gillander, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gadin, Katja Gillander

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
Full Text
View/download PDF

33. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gadin, Katja Gillander, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gadin, Katja Gillander

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
Full Text
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34. Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination

Author

Tea, F, Lopez, JA, Ramanathan, S, Merheb, V, Lee, FXZ, Zou, A, Pilli, D, Patrick, E, van der Walt, A, Monif, M, Tantsis, EM, Yiu, EM, Vucic, S, Henderson, APD, Fok, A, Fraser, CL, Lechner-Scott, J, Reddel, SW, Broadley, S, Barnett, MH, Brown, DA, Lunemann, JD, Dale, RC, Brilot, F, Sinclair, A, Kermode, AG, Kornberg, A, Bye, A, McGettigan, B, Trewin, B, Brew, B, Taylor, B, Bundell, C, Miteff, C, Troedson, C, Pridmore, C, Spooner, C, Yiannikas, C, O'Gorman, C, Clark, D, Suan, D, Jones, D, Kilfoyle, D, Gill, D, Wakefield, D, Hofmann, D, Mathey, E, O'Grady, G, Jones, HF, Beadnall, H, Butzkueven, H, Joshi, H, Andrews, I, Sutton, I, MacIntyre, J, Sandbach, JM, Freeman, J, King, J, O'Neill, JH, Parratt, J, Barton, J, Garber, J, Ahmad, K, Riney, K, Buzzard, K, Kothur, K, Cantrill, LC, Menezes, MP, Paine, MA, Marriot, M, Ghadiri, M, Boggild, M, Lawlor, M, Badve, M, Ryan, M, Aaqib, M, Shuey, N, Jordan, N, Urriola, N, Lawn, N, White, O, McCombe, P, Patel, R, Leventer, R, Webster, R, Smith, R, Gupta, S, Mohammad, SS, Pillai, S, Hawke, S, Simon, S, Calvert, S, Blum, S, Malone, S, Hodgkinson, S, Nguyen, TK, Hardy, TA, Kalincik, T, Ware, T, Fung, VSC, Huynh, W, Tea, F, Lopez, JA, Ramanathan, S, Merheb, V, Lee, FXZ, Zou, A, Pilli, D, Patrick, E, van der Walt, A, Monif, M, Tantsis, EM, Yiu, EM, Vucic, S, Henderson, APD, Fok, A, Fraser, CL, Lechner-Scott, J, Reddel, SW, Broadley, S, Barnett, MH, Brown, DA, Lunemann, JD, Dale, RC, Brilot, F, Sinclair, A, Kermode, AG, Kornberg, A, Bye, A, McGettigan, B, Trewin, B, Brew, B, Taylor, B, Bundell, C, Miteff, C, Troedson, C, Pridmore, C, Spooner, C, Yiannikas, C, O'Gorman, C, Clark, D, Suan, D, Jones, D, Kilfoyle, D, Gill, D, Wakefield, D, Hofmann, D, Mathey, E, O'Grady, G, Jones, HF, Beadnall, H, Butzkueven, H, Joshi, H, Andrews, I, Sutton, I, MacIntyre, J, Sandbach, JM, Freeman, J, King, J, O'Neill, JH, Parratt, J, Barton, J, Garber, J, Ahmad, K, Riney, K, Buzzard, K, Kothur, K, Cantrill, LC, Menezes, MP, Paine, MA, Marriot, M, Ghadiri, M, Boggild, M, Lawlor, M, Badve, M, Ryan, M, Aaqib, M, Shuey, N, Jordan, N, Urriola, N, Lawn, N, White, O, McCombe, P, Patel, R, Leventer, R, Webster, R, Smith, R, Gupta, S, Mohammad, SS, Pillai, S, Hawke, S, Simon, S, Calvert, S, Blum, S, Malone, S, Hodgkinson, S, Nguyen, TK, Hardy, TA, Kalincik, T, Ware, T, Fung, VSC, and Huynh, W

Abstract

Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves, spinal cord, and brain. While the clinical relevance of MOG Ab detection is becoming increasingly clear as therapeutic and prognostic differences from multiple sclerosis are acknowledged, an in-depth characterization of human MOG Ab is required to answer key challenges in patient diagnosis, treatment, and prognosis. Herein, we investigated the epitope, binding sensitivity, and affinity of MOG Ab in a cohort of 139 and 148 MOG antibody-seropositive children and adults (n = 287 patients at baseline, 130 longitudinal samples, and 22 cerebrospinal fluid samples). MOG extracellular domain was also immobilized to determine the affinity of MOG Ab. MOG Ab response was of immunoglobulin G1 isotype, and was of peripheral rather than intrathecal origin. High affinity MOG Ab were detected in 15% paediatric and 18% adult sera. More than 75% of paediatric and adult MOG Ab targeted a dominant extracellular antigenic region around Proline42. MOG Ab titers fluctuated over the progression of disease, but affinity and reactivity to Proline42 remained stable. Adults with a relapsing course intrinsically presented with a reduced immunoreactivity to Proline42 and had a more diverse MOG Ab response, a feature that may be harnessed for predicting relapse. Higher titers of MOG Ab were observed in more severe phenotypes and during active disease, supporting the pathogenic role of MOG Ab. Loss of MOG Ab seropositivity was observed upon conformational changes to MOG, and this greatly impacted the sensitivity of the detection of relapsing disorders, largely considered as more severe. Careful consideration of the binding characteristics of autoantigens should be taken into account when detecting disease-relevant autoantibodies.

Published
2019

35. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gadin, Katja Gillander, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gadin, Katja Gillander

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
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36. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gadin, Katja Gillander, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gadin, Katja Gillander

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
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37. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gillander Gådin, Katja, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gillander Gådin, Katja

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
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38. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gillander Gådin, Katja, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gillander Gådin, Katja

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
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39. Interaction between Shift Work and Established Coronary Risk Factors

Author

Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, Gillander Gådin, Katja, Hermansson, Jonas, Boggild, Henrik, Hallqvist, Johan, Karlsson, Berndt, Knutsson, Anders, Nilsson, Tohr, Reuterwall, Christina, and Gillander Gådin, Katja

Abstract

Background: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. Objective: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. Methods: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. Results: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). Conclusion: Shift work and some established coronary risk factors have significant interactions.

Published
2019
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40. Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016 A GeoSentinel Analysis

Author

Hamer, Davidson H., Barbre, Kira A., Chen, Lin H., Grobusch, Martin P., Schlagenhauf, Patricia, Goorhuis, Abraham, van Genderen, Perry J. J., Molina, Israel, Asgeirsson, Hilmir, Kozarsky, Phyllis E., Caumes, Eric, Hagmann, Stefan H., Mockenhaupt, Frank P., Eperon, Gilles, Barnett, Elizabeth D., Bottieau, Emmanuel, Boggild, Andrea K., Gautret, Philippe, Hynes, Noreen A., Kuhn, Susan, Lash, Ryan, Leder, Karin, Libman, Michael, Malvy, Denis J. M., Perret, Cecilia, Rothe, Camilla, Schwartz, Eli, Wilder-Smith, Annelies, Cetron, Martin S., Esposito, Douglas H., Hamer, Davidson H., Barbre, Kira A., Chen, Lin H., Grobusch, Martin P., Schlagenhauf, Patricia, Goorhuis, Abraham, van Genderen, Perry J. J., Molina, Israel, Asgeirsson, Hilmir, Kozarsky, Phyllis E., Caumes, Eric, Hagmann, Stefan H., Mockenhaupt, Frank P., Eperon, Gilles, Barnett, Elizabeth D., Bottieau, Emmanuel, Boggild, Andrea K., Gautret, Philippe, Hynes, Noreen A., Kuhn, Susan, Lash, Ryan, Leder, Karin, Libman, Michael, Malvy, Denis J. M., Perret, Cecilia, Rothe, Camilla, Schwartz, Eli, Wilder-Smith, Annelies, Cetron, Martin S., and Esposito, Douglas H.

Abstract

Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016. Measurements: Frequencies of demographic, trip, and clinical characteristics and complications. Results: Starting in May 2015, 93 cases of Zika virus disease were reported. Common symptoms included exanthema (88%), fever (76%), and arthralgia (72%). Fifty-nine percent of patients were exposed in South America; 71% were diagnosed in Europe. Case status was established most commonly by polymerase chain reaction (PCR) testing of blood and less often by PCR testing of other body fluids or serology and plaque-reduction neutralization testing. Two patients developed Guillain-Barre syndrome, and 3 of 4 pregnancies had adverse outcomes (microcephaly, major fetal neurologic abnormalities, and intrauterine fetal death). Limitation: Surveillance data collected by specialized clinics may not be representative of all ill returned travelers, and denominator data are unavailable. Conclusion: These surveillance data help characterize the clinical manifestations and adverse outcomes of Zika virus disease among travelers infected in the Americas and show a need for global standardization of diagnostic testing. The serious fetal complications observed in this study highlight the importance of travel advisories and prevention measures for pregnant women and their partners. Travelers are sentinels for global Zika virus circulation and may facilitate further transmission.

Published
2017
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41. Incidence and prevalence of NMOSD in Australia and New Zealand

Author

Bukhari, W., Prain, K.M., Waters, P., Woodhall, M., O‘Gorman, C.M., Clarke, L., Silvestrini, R.A., Bundell, C.S., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brown, M., Brownlee, W.J., Butzkueven, H., Carroll, W.M., Chen, C., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fabis-Pedrini, M.J., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez-Sanchez, S., Killpatrick, T., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M., Lynch, C., Macdonell, R., Mason, D.F., McCombe, P.A., Pender, M.P., Pereira, J.A., Pollard, J.D., Reddel, S.W., Shaw, C., Spies, J., Stankovich, J., Sutton, I., Vucic, S., Walsh, M., Wong, R.C., Yiu, E.M., Barnett, M.H., Kermode, A.G., Marriott, M.P., Parratt, J.D.E., Slee, M., Taylor, B.V., Willoughby, E., Wilson, R.J., Vincent, A., Broadley, S.A., Bukhari, W., Prain, K.M., Waters, P., Woodhall, M., O‘Gorman, C.M., Clarke, L., Silvestrini, R.A., Bundell, C.S., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brown, M., Brownlee, W.J., Butzkueven, H., Carroll, W.M., Chen, C., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fabis-Pedrini, M.J., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez-Sanchez, S., Killpatrick, T., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M., Lynch, C., Macdonell, R., Mason, D.F., McCombe, P.A., Pender, M.P., Pereira, J.A., Pollard, J.D., Reddel, S.W., Shaw, C., Spies, J., Stankovich, J., Sutton, I., Vucic, S., Walsh, M., Wong, R.C., Yiu, E.M., Barnett, M.H., Kermode, A.G., Marriott, M.P., Parratt, J.D.E., Slee, M., Taylor, B.V., Willoughby, E., Wilson, R.J., Vincent, A., and Broadley, S.A.

Abstract

OBJECTIVES: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. BACKGROUND: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. METHODS: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. RESULTS: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. CONCLUSIONS: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.

Published
2017

42. Measurement of azimuthal correlations of D mesons with charged particles in pp collisions at root s=7 TeV and p-Pb collisions at root(NN)-N-s=5.02 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Aiola, S., Akindinov, A., Alam, S. N., Albuquerque, D. S. D., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Prado, C. Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshauser, H., Arcelli, S., Arnaldi, R., Arnold, O. W., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Balasubramanian, S., Baldisseri, A., Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Beltran, L. G. E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biro, G., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Bonora, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Bourjau, C., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buitron, S. A. I., Buncic, P., Busch, O., Buthelezi, Z., Butt, J. B., Buxton, J. T., Cabala, J., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Carnesecchi, F., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Sanchez, C. Ceballos, Cepila, J., Cerello, P., Cerkala, J., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chauvin, A., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Cho, S., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Maldonado, I. Cortes, Cortese, P., Cosentino, M. R., Costa, F., Crkovska, J., Crochet, P., Albino, R. Cruz, Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danisch, M. C., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Conti, C., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., De Souza, R. D., Deisting, A., Deloff, A., Denes, E., Deplano, C., Dhankher, P., Di Bari, D., Di Mauro, A., Di Nezza, P., Di Ruzza, B., Corchero, M. A. Diaz, Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Gimenez, D. Domenicis, Donigus, B., Dordic, O., Drozhzhova, T., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Endress, E., Engel, H., Epple, E., Erazmus, B., Erdemir, I., Erhardt, F., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Feliciello, A., Feofilov, G., Ferencei, J., Tellez, A. Fernandez, Ferreiro, E. G., Ferretti, A., Festanti, A., Feuillard, V. J. G., Figiel, J., Figueredo, M. A. S., Filchagin, S., Finogeev, D., Fionda, F. M., Fiore, E. M., Fleck, M. G., Floris, M., Foertsch, S., Foka, P., Fokin, S., Fragiacomo, E., Francescon, A., Francisco, A., Frankenfeld, U., Fronze, G. G., Fuchs, U., Furget, C., Furs, A., Girard, M. Fusco, Gaardhoje, J. J., Gagliardi, M., Gago, A. M., Gajdosova, K., Gallio, M., Galvan, C. D., Gangadharan, D. R., Ganoti, P., Gao, C., Garabatos, C., Garcia-Solis, E., Gargiulo, C., Gasik, P., Gauger, E. F., Germain, M., Gheata, M., Ghosh, P., Ghosh, S. K., Gianotti, P., Giubellino, P., Giubilato, P., Gladysz-Dziadus, E., Glassel, P., Coral, D. M. Gomez, Ramirez, A. Gomez, Gonzalez, A. S., Gonzalez, V., Gonzalez-Zamora, P., Gorbunov, S., Gorlich, L., Gotovac, S., Grabski, V., Grachov, O. A., Graczykowski, L. K., Graham, K. L., Grelli, A., Grigoras, A., Grigoras, C., Grigoriev, V., Grigoryan, A., Grigoryan, S., Grinyov, B., Grion, N., Gronefeld, J. M., Grosse-Oetringhaus, J. F., Grosso, R., Gruber, L., Guber, F., Guernane, R., Guerzoni, B., Gulbrandsen, K., Gunji, T., Gupta, A., Gupta, R., Haake, R., Hadjidakis, C., Haiduc, M., Hamagaki, H., Hamar, G., Hamon, J. C., Harris, J. W., Harton, A., Hatzifotiadou, D., Hayashi, S., Heckel, S. T., Hellbar, E., Helstrup, H., Herghelegiu, A., Corral, G. Herrera, Hess, B. A., Hetland, K. F., Hillemanns, H., Hippolyte, B., Horak, D., Hosokawa, R., Hristov, P., Hughes, C., Humanic, T. J., Hussain, N., Hussain, T., Hutter, D., Hwang, D. S., Ilkaev, R., Inaba, M., Incani, E., Ippolitov, M., Irfan, M., Isakov, V., Ivanov, M., Ivanov, V., Izucheev, V., Jacak, B., Jacazio, N., Jacobs, P. M., Jadhav, M. B., Jadlovska, S., Jadlovsky, J., Jahnke, C., Jakubowska, M. J., Janik, M. A., Jayarathna, P. H. S. Y., Jena, C., Jena, S., Bustamante, R. T. Jimenez, Jones, P. G., Jusko, A., Kalinak, P., Kalweit, A., Kang, J. H., Kaplin, V., Kar, S., Uysal, A. Karasu, Karavichev, O., Karavicheva, T., Karayan, L., Karpechev, E., Kebschull, U., Keidel, R., Keijdener, D. L. D., Keil, M., Khan, M. Mohisin, Khan, P., Khan, S. A., Khanzadeev, A., Kharlov, Y., Kileng, B., Kim, D. W., Kim, D. J., Kim, D., Kim, H., Kim, J. S., Kim, J., Kim, M., Kim, S., Kim, T., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kiss, G., Klay, J. L., Klein, C., Klein, J., Klein-Bosing, C., Klewin, S., Kluge, A., Knichel, M. L., Knospe, A. G., Kobdaj, C., Kofarago, M., Kollegger, T., Kolojvari, A., Kondratiev, V., Kondratyeva, N., Kondratyuk, E., Konevskikh, A., Kopcik, M., Kour, M., Kouzinopoulos, C., Kovalenko, O., Kovalenko, V., Kowalski, M., Meethaleveedu, G. Koyithatta, Kralik, I., Kravcakova, A., Krivda, M., Krizek, F., Kryshen, E., Krzewicki, M., Kubera, A. M., Kucera, V., Kuhn, C., Kuijer, P. G., Kumar, A., Kumar, J., Kumar, L., Kumar, S., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kweon, M. J., Kwon, Y., La Pointe, S. L., La Rocca, P., de Guevara, P. Ladron, Fernandes, C. Lagana, Lakomov, I., Langoy, R., Lapidus, K., Lara, C., Lardeux, A., Lattuca, A., Laudi, E., Lea, R., Leardini, L., Lee, S., Lehas, F., Lehner, S., Lemmon, R. C., Lenti, V., Leogrande, E., Monzon, I. Leon, Vargas, H. Leon, Leoncino, M., Levai, P., Li, S., Li, X., Lien, J., Lietava, R., Lindal, S., Lindenstruth, V., Lippmann, C., Lisa, M. A., Ljunggren, H. M., Lodato, D. F., Loenne, P. I., Loginov, V., Loizides, C., Lopez, X., Torres, E. Lopez, Lowe, A., Luettig, P., Lunardon, M., Luparello, G., Lupi, M., Lutz, T. H., Maevskaya, A., Mager, M., Mahajan, S., Mahmood, S. M., Maire, A., Majka, R. D., Malaev, M., Cervantes, I. Maldonado, Malinina, L., Mal'Kevich, D., Malzacher, P., Mamonov, A., Manko, V., Manso, F., Manzari, V., Mao, Y., Marchisone, M., Mares, J., Margagliotti, G. V., Margotti, A., Margutti, J., Marin, A., Markert, C., Marquard, M., Martin, N. A., Martinengo, P., Martinez, M. I., Garcia, G. Martinez, Pedreira, M. Martinez, Mas, A., Masciocchi, S., Masera, M., Masoni, A., Mastroserio, A., Matyja, A., Mayer, C., Mazer, J., Mazzoni, M. A., Mcdonald, D., Meddi, F., Melikyan, Y., Menchaca-Rocha, A., Meninno, E., Perez, J. Mercado, Meres, M., Mhlanga, S., Miake, Y., Mieskolainen, M. M., Mikhaylov, K., Milano, L., Milosevic, J., Mischke, A., Mishra, A. N., Miskowiec, D., Mitra, J., Mitu, C. M., Mohammadi, N., Mohanty, B., Molnar, L., Zetina, L. Montano, Montes, E., De Godoy, D. A. Moreira, Moreno, L. A. P., Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muhlheim, D., Muhuri, S., Mukherjee, M., Mulligan, J. D., Munhoz, M. G., Munning, K., Munzer, R. H., Murakami, H., Murray, S., Musa, L., Musinsky, J., Naik, B., Nair, R., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., da Luz, H. Natal, Nattrass, C., Navarro, S. R., Nayak, K., Nayak, R., Nayak, T. K., Nazarenko, S., Nedosekin, A., De Oliveira, R. A. Negrao, Nellen, L., Ng, F., Nicassio, M., Niculescu, M., Niedziela, J., Nielsen, B. 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Abstract

The azimuthal correlations of D mesons with charged particles were measured with the ALICE apparatus in pp collisions at root s = 7 TeV and p-Pb collisions at root sNN = 5.02 TeV at the Large Hadron Collider. D-0, D+, and D*+ mesons and their charge conjugates with transverse momentum 3 0.3 GeV/c. The yield of charged particles in the correlation peak induced by the jet containing the D meson and the peak width are compatible within uncertainties in the two collision systems. The data are described within uncertainties by Monte-Carlo simulations based on PYTHIA, POWHEG, and EPOS 3 event generators.

Published
2017

43. Charged-particle multiplicities in proton-proton collisions at root s=0.9 to 8 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahmed, I., Ahn, S. U., Aiola, S., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Alfaro Molina, R., Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Alves Garcia Prado, C., Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshauser, H., Arcelli, S., Arnaldi, R., Arnold, O. W., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoldi, G. G., Barnby, L. 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Abstract

A detailed study of pseudorapidity densities and multiplicity distributions of primary charged particles produced in proton-proton collisions, atv root s = 0.9, 2.36, 2.76, 7 and 8 TeV, in the pseudorapidity range vertical bar n vertical bar<2, was carried out using the ALICE detector. Measurements were obtained for three event classes: inelastic, non-single diffractive and events with at least one charged particle in the pseudorapidity interval vertical bar n vertical bar

Published
2017

44. phi-Meson production at forward rapidity in p-Pb collisions at root s(NN)=5.02 TeV and in pp collisions at root s=2.76 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Alves Garcia Prado, C., Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaser, H., Arcelli, S., Armesto, N., Arnaldi, R., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Bello Martinez, H., Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Bottger, S., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Butt, J. B., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Carnesecchi, F., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Cavicchioli, C., Sanchez, C. Ceballos, Cepila, J., Cerello, P., Cerkala, J., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Chunhui, Z., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Cortes Maldonado, I., Cortese, P., Cosentino, M. R., Costa, F., Crochet, P., Albino, R. Cruz, Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., Deisting, A., Deloff, A., Denes, E., D'Erasmo, G., Di Bari, D., Di Mauro, A., Di Nezza, P., Corchero, M. A. Diaz, Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Dobrowolski, T., Domenicis Gimenez, D., Donigus, B., Dordic, O., Drozhzhova, T., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Engel, H., Erazmus, B., Erdemir, I., Erhardt, F., Eschweiler, D., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Felea, D., Feliciello, A., Feofilov, G., Ferencei, J., Fernandez Tellez, A., Ferreiro, E. G., Ferretti, A., Festanti, A., Feuillard, V. J. G., Figiel, J., Figueredo, M. A. S., Filchagin, S., Finogeev, D., Fionda, F. M., Fiore, E. M., Fleck, M. G., Floris, M., Foertsch, S., Foka, P., Fokin, S., Fragiacomo, E., Francescon, A., Frankenfeld, U., Fuchs, U., Furget, C., Furs, A., Girard, M. Fusco, Gaardhoje, J. J., Gagliardi, M., Gago, A. M., Gallio, M., Gangadharan, D. R., Ganoti, P., Gao, C., Garabatos, C., Garcia-Solis, E., Gargiulo, C., Gasik, P., Germain, M., Gheata, A., Gheata, M., Ghosh, P., Ghosh, S. K., Gianotti, P., Giubellino, P., Giubilato, P., Gladysz-Dziadus, E., Glassel, P., Coral, D. M. Gomez, Ramirez, A. Gomez, Gonzalez-Zamora, P., Gorbunov, S., Gorlich, L., Gotovac, S., Grabski, V., Graczykowski, L. K., Graham, K. L., Grelli, A., Grigoras, A., Grigoras, C., Grigoriev, V., Grigoryan, A., Grigoryan, S., Grinyov, B., Grion, N., Grosse-Oetringhaus, J. F., Grossiord, J-Y., Grosso, R., Guber, F., Guernane, R., Guerzoni, B., Gulbrandsen, K., Gulkanyan, H., Gunji, T., Gupta, A., Gupta, R., Haake, R., Haaland, O., Hadjidakis, C., Haiduc, M., Hamagaki, H., Hamar, G., Hansen, A., Harris, J. W., Hartmann, H., Harton, A., Hatzifotiadou, D., Hayashi, S., Heckel, S. T., Heide, M., Helstrup, H., Herghelegiu, A., Corral, G. Herrera, Hess, B. A., Hetland, K. F., Hilden, T. E., Hillemanns, H., Hippolyte, B., Hosokawa, R., Hristov, P., Huang, M., Humanic, T. J., Hussain, N., Hussain, T., Hutter, D., Hwang, D. S., Ilkaev, R., Ilkiv, I., Inaba, M., Ippolitov, M., Irfan, M., Ivanov, M., Ivanov, V., Izucheev, V., Jacobs, P. M., Jadlovska, S., Jahnke, C., Jang, H. J., Janik, M. A., Jayarathna, P. H. S. Y., Jena, C., Jena, S., Bustamante, R. T. Jimenez, Jones, P. G., Jung, H., Jusko, A., Kalinak, P., Kalweit, A., Kamin, J., Kang, J. H., Kaplin, V., Kar, S., Uysal, A. Karasu, Karavichev, O., Karavicheva, T., Karayan, L., Karpechev, E., Kebschull, U., Keidel, R., Keijdener, D. L. D., Keil, M., Khan, K. H., Khan, M. M., Khan, P., Khan, S. A., Khanzadeev, A., Kharlov, Y., Kileng, B., Kim, B., Kim, D. J., Kim, H., Kim, J. S., Kim, M., Kim, S., Kim, T., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kiss, G., Klay, J. L., Klein, C., Klein, J., Klein-Bosing, C., Kluge, A., Knichel, M. L., Knospe, A. G., Kobayashi, T., Kobdaj, C., Kofarago, M., Kollegger, T., Kolojvari, A., Kondratiev, V., Kondratyeva, N., Kondratyuk, E., Konevskikh, A., Kopcik, M., Kour, M., Kouzinopoulos, C., Kovalenko, O., Kovalenko, V., Kowalski, M., Meethaleveedu, G. Koyithatta, Kral, J., Kralik, I., Kravcakova, A., Kretz, M., Krivda, M., Krizek, F., Kryshen, E., Krzewicki, M., Kubera, A. M., Kucera, V., Kugathasan, T., Kuhn, C., Kuijer, P. G., Kumar, A., Kumar, J., Kumar, L., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kushpil, S., Kweon, M. J., Kwon, Y., La Pointe, S. L., La Rocca, P., Lagana Fernandes, C., Lakomov, I., Langoy, R., Lara, C., Lardeux, A., Lattuca, A., Laudi, E., Lea, R., Leardini, L., Lee, G. R., Lee, S., Legrand, I., Lehas, F., Lemmon, R. C., Lenti, V., Leogrande, E., Leon Monzon, I., Leoncino, M., Levai, P., Li, S., Li, X., Lien, J., Lietava, R., Lindal, S., Lindenstruth, V., Lippmann, C., Lisa, M. A., Ljunggren, H. M., Lodato, D. F., Loenne, P. I., Loginov, V., Loizides, C., Lopez, X., Torres, E. Lopez, Lowe, A., Luettig, P., Lunardon, M., Luparello, G., Luz, P. H. F. N. D., Maevskaya, A., Mager, M., Mahajan, S., Mahmood, S. M., Maire, A., Majka, R. D., Malaev, M., Cervantes, I. Maldonado, Malinina, L., Mal'Kevich, D., Malzacher, P., Mamonov, A., Manko, V., Manso, F., Manzari, V., Marchisone, M., Mares, J., Margagliotti, G. V., Margotti, A., Margutti, J., Marin, A., Markert, C., Marquard, M., Martin, N. A., Blanco, J. Martin, Martinengo, P., Martinez, M. I., Garcia, G. Martinez, Pedreira, M. Martinez, Martynov, Y., Mas, A., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Masui, H., Matyja, A., Mayer, C., Mazer, J., Mazzoni, M. A., Mcdonald, D., Meddi, F., Melikyan, Y., Menchaca-Rocha, A., Meninno, E., Perez, J. Mercado, Meres, M., Miake, Y., Mieskolainen, M. M., Mikhaylov, K., Milano, L., Milosevic, J., Minervini, L. M., Mischke, A., Mishra, A. N., Miskowiec, D., Mitra, J., Mitu, C. M., Mohammadi, N., Mohanty, B., Molnar, L., Zetina, L. Montano, Montes, E., Morando, M., De Godoy, D. A. Moreira, Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muhlheim, D., Muhuri, S., Mukherjee, M., Mulligan, J. D., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., Nattrass, C., Nayak, K., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nellen, L., Ng, F., Nicassio, M., Niculescu, M., Niedziela, J., Nielsen, B. S., Nikolaev, S., Nikulin, S., Nikulin, V., Noferini, F., Nomokonov, P., Nooren, G., Noris, J. C. C., Norman, J., Nyanin, A., Nystrand, J., Oeschler, H., Oh, S., Oh, S. K., Ohlson, A., Okatan, A., Okubo, T., Olah, L., Oleniacz, J., Oliveira Da Silva, A. C., Oliver, M. H., Onderwaater, J., Oppedisano, C., Orava, R., Velasquez, A. Ortiz, Oskarsson, A., Otwinowski, J., Oyama, K., Ozdemir, M., Pachmayer, Y., Pagano, P., Paic, G., Pajares, C., Pal, S. K., Pan, J., Pandey, A. K., Pant, D., Papcun, P., Papikyan, V., Pappalardo, G. S., Pareek, P., Park, W. J., Parmar, S., Passfeld, A., Paticchio, V., Patra, R. N., Paul, B., Peitzmann, T., Pereira Da Costa, H., Pereira De Oliveira Filho, E., Peresunko, D., Lara, C. E. Perez, Lezama, E. Perez, Peskov, V., Pestov, Y., Petracek, V., Petrov, V., Petrovici, M., Petta, C., Piano, S., Pikna, M., Pillot, P., Pinazza, O., Pinsky, L., Piyarathna, D. B., Ploskon, M., Planinic, M., Pluta, J., Pochybova, S., Podesta-Lerma, P. L. M., Poghosyan, M. G., Polichtchouk, B., Poljak, N., Poonsawat, W., Pop, A., Porteboeuf-Houssais, S., Porter, J., Pospisil, J., Prasad, S. K., Preghenella, R., Prino, F., Pruneau, C. A., Pshenichnov, I., Puccio, M., Puddu, G., Pujahari, P., Punin, V., Putschke, J., Qvigstad, H., Rachevski, A., Raha, S., Rajput, S., Rak, J., Rakotozafindrabe, A., Ramello, L., Rami, F., Raniwala, R., Raniwala, S., Räsänen, S. S., Rascanu, B. T., Rathee, D., Read, K. F., Real, J. S., Redlich, K., Reed, R. J., Rehman, A., Reichelt, P., Reidt, F., Ren, X., Renfordt, R., Reolon, A. R., Reshetin, A., Rettig, F., Revol, J-P., Reygers, K., Riabov, V., Ricci, R. A., Richert, T., Richter, M., Riedler, P., Riegler, W., Riggi, F., Ristea, C., Rivetti, A., Rocco, E., Rodriguez Cahuantzi, M., Manso, A. Rodriguez, Roed, K., Rogochaya, E., Rohr, D., Rohrich, D., Romita, R., Ronchetti, F., Ronflette, L., Rosnet, P., Rossi, A., Roukoutakis, F., Roy, A., Roy, C., Roy, P., Montero, A. J. Rubio, Rui, R., Russo, R., Ryabinkin, E., Ryabov, Y., Rybicki, A., Sadovsky, S., Safarik, K., Sahlmuller, B., Sahoo, P., Sahoo, R., Sahoo, S., Sahu, P. K., Saini, J., Sakai, S., Saleh, M. A., Salgado, C. A., Salzwedel, J., Sambyal, S., Samsonov, V., Castro, X. Sanchez, Sandor, L., Sandoval, A., Sano, M., Sarkar, D., Scapparone, E., Scarlassara, F., Scharenberg, R. P., Schiaua, C., Schicker, R., Schmidt, C., Schmidt, H. R., Schuchmann, S., Schukraft, J., Schulc, M., Schuster, T., Schutz, Y., Schwarz, K., Schweda, K., Scioli, G., Scomparin, E., Scott, R., Seger, J. E., Sekiguchi, Y., Sekihata, D., Selyuzhenkov, I., Senosi, K., Seo, J., Serradilla, E., Sevcenco, A., Shabanov, A., Shabetai, A., Shadura, O., Shahoyan, R., Shangaraev, A., Sharma, A., Sharma, M., Sharma, N., Shigaki, K., Shtejer, K., Sibiriak, Y., Siddhanta, S., Sielewicz, K. M., Siemiarczuk, T., Silvermyr, D., Silvestre, C., Simatovic, G., Simonetti, G., Singaraju, R., Singh, R., Singha, S., Singhal, V., Sinha, B. C., Sinha, T., Sitar, B., Sitta, M., Skaali, T. B., Slupecki, M., Smirnov, N., Snellings, R. J. M., Snellman, T. W., Sogaard, C., Soltz, R., Song, J., Song, M., Song, Z., Soramel, F., Sorensen, S., Spacek, M., Spiriti, E., Sputowska, I., Spyropoulou-Stassinaki, M., Srivastava, B. K., Stachel, J., Stan, I., Stefanek, G., Steinpreis, M., Stenlund, E., Steyn, G., Stiller, J. H., Stocco, D., Strmen, P., Suaide, A. A. P., Sugitate, T., Suire, C., Suleymanov, M., Sultanov, R., Sumbera, M., Symons, T. J. M., Szabo, A., de Toledo, A. Szanto, Szarka, I., Szczepankiewicz, A., Szymanski, M., Tabassam, U., Takahashi, J., Tambave, G. J., Tanaka, N., Tangaro, M. A., Takaki, J. D. Tapia, Peloni, A. Tarantola, Tarhini, M., Tariq, M., Tarzila, M. G., Tauro, A., Tejeda Munoz, G., Telesca, A., Terasaki, K., Terrevoli, C., Teyssier, B., Thader, J., Thomas, D., Tieulent, R., Timmins, A. R., Toia, A., Trogolo, S., Trubnikov, V., Trzaska, W. H., Tsuji, T., Tumkin, A., Turrisi, R., Tveter, T. S., Ullaland, K., Uras, A., Usai, G. L., Utrobicic, A., Vajzer, M., Vala, M., Palomo, L. Valencia, Vallero, S., Van Der Maarel, J., Van Hoorne, J. W., van Leeuwen, M., Vanat, T., Vande Vyvre, P., Varga, D., Vargas, A., Vargyas, M., Varma, R., Vasileiou, M., Vasiliev, A., Vauthier, A., Vechernin, V., Veen, A. M., Veldhoen, M., Velure, A., Venaruzzo, M., Vercellin, E., Vergara Limon, S., Vernet, R., Verweij, M., Vickovic, L., Viesti, G., Viinikainen, J., Vilakazi, Z., Baillie, O. Villalobos, Vinogradov, A., Vinogradov, L., Vinogradov, Y., Virgili, T., Vislavicius, V., Viyogi, Y. P., Vodopyanov, A., Volkl, M. A., Voloshin, K., Voloshin, S. A., Volpe, G., von Haller, B., Vorobyev, I., Vranic, D., Vrlakova, J., Vulpescu, B., Vyushin, A., Wagner, B., Wagner, J., Wang, H., Wang, M., Wang, Y., Watanabe, D., Watanabe, Y., Weber, M., Weber, S. G., Wessels, J. P., Westerhoff, U., Wiechula, J., Wikne, J., Wilde, M., Wilk, G., Wilkinson, J., Williams, M. C. S., Windelband, B., Winn, M., Yaldo, C. G., Yang, H., Yang, P., Yano, S., Yin, Z., Yokoyama, H., Yoo, I-K., Yurchenko, V., Yushmanov, I., Zaborowska, A., Zaccolo, V., Zaman, A., Zampolli, C., Zanoli, H. J. C., Zaporozhets, S., Zardoshti, N., Zarochentsev, A., Zavada, P., Zaviyalov, N., Zbroszczyk, H., Zgura, I. S., Zhalov, M., Zhang, H., Zhang, X., Zhang, Y., Zhao, C., Zhigareva, N., Zhou, D., Zhou, Y., Zhou, Z., Zhu, H., Zhu, J., Zhu, X., Zichichi, A., Zimmermann, A., Zimmermann, M. B., Zinovjev, G., Zyzak, M., University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. 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A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Bottger, S., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Butt, J. B., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Carnesecchi, F., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Cavicchioli, C., Sanchez, C. Ceballos, Cepila, J., Cerello, P., Cerkala, J., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Chunhui, Z., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Cortes Maldonado, I., Cortese, P., Cosentino, M. R., Costa, F., Crochet, P., Albino, R. Cruz, Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., Deisting, A., Deloff, A., Denes, E., D'Erasmo, G., Di Bari, D., Di Mauro, A., Di Nezza, P., Corchero, M. A. Diaz, Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Dobrowolski, T., Domenicis Gimenez, D., Donigus, B., Dordic, O., Drozhzhova, T., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Engel, H., Erazmus, B., Erdemir, I., Erhardt, F., Eschweiler, D., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Felea, D., Feliciello, A., Feofilov, G., Ferencei, J., Fernandez Tellez, A., Ferreiro, E. G., Ferretti, A., Festanti, A., Feuillard, V. J. G., Figiel, J., Figueredo, M. A. S., Filchagin, S., Finogeev, D., Fionda, F. M., Fiore, E. M., Fleck, M. G., Floris, M., Foertsch, S., Foka, P., Fokin, S., Fragiacomo, E., Francescon, A., Frankenfeld, U., Fuchs, U., Furget, C., Furs, A., Girard, M. Fusco, Gaardhoje, J. J., Gagliardi, M., Gago, A. M., Gallio, M., Gangadharan, D. 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I., Loginov, V., Loizides, C., Lopez, X., Torres, E. Lopez, Lowe, A., Luettig, P., Lunardon, M., Luparello, G., Luz, P. H. F. N. D., Maevskaya, A., Mager, M., Mahajan, S., Mahmood, S. M., Maire, A., Majka, R. D., Malaev, M., Cervantes, I. Maldonado, Malinina, L., Mal'Kevich, D., Malzacher, P., Mamonov, A., Manko, V., Manso, F., Manzari, V., Marchisone, M., Mares, J., Margagliotti, G. V., Margotti, A., Margutti, J., Marin, A., Markert, C., Marquard, M., Martin, N. A., Blanco, J. Martin, Martinengo, P., Martinez, M. I., Garcia, G. Martinez, Pedreira, M. Martinez, Martynov, Y., Mas, A., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Masui, H., Matyja, A., Mayer, C., Mazer, J., Mazzoni, M. A., Mcdonald, D., Meddi, F., Melikyan, Y., Menchaca-Rocha, A., Meninno, E., Perez, J. Mercado, Meres, M., Miake, Y., Mieskolainen, M. M., Mikhaylov, K., Milano, L., Milosevic, J., Minervini, L. M., Mischke, A., Mishra, A. N., Miskowiec, D., Mitra, J., Mitu, C. 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S., Zhalov, M., Zhang, H., Zhang, X., Zhang, Y., Zhao, C., Zhigareva, N., Zhou, D., Zhou, Y., Zhou, Z., Zhu, H., Zhu, J., Zhu, X., Zichichi, A., Zimmermann, A., Zimmermann, M. B., Zinovjev, G., and Zyzak, M.

Abstract

The first study of phi-meson production in p-Pb collisions at forward and backward rapidity, at a nucleonnucleon centre-of-mass energy root s(NN)= 5.02 TeV, has been performed with the ALICE apparatus at the LHC. The phi-mesons have been identified in the dimuon decay channel in the transverse momentum (p(T)) range 1

Published
2017

45. Incidence and prevalence of NMOSD in Australia and New Zealand

Author

Bukhari, W., Prain, K.M., Waters, P., Woodhall, M., O‘Gorman, C.M., Clarke, L., Silvestrini, R.A., Bundell, C.S., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brown, M., Brownlee, W.J., Butzkueven, H., Carroll, W.M., Chen, C., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fabis-Pedrini, M.J., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez-Sanchez, S., Killpatrick, T., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M., Lynch, C., Macdonell, R., Mason, D.F., McCombe, P.A., Pender, M.P., Pereira, J.A., Pollard, J.D., Reddel, S.W., Shaw, C., Spies, J., Stankovich, J., Sutton, I., Vucic, S., Walsh, M., Wong, R.C., Yiu, E.M., Barnett, M.H., Kermode, A.G., Marriott, M.P., Parratt, J.D.E., Slee, M., Taylor, B.V., Willoughby, E., Wilson, R.J., Vincent, A., Broadley, S.A., Bukhari, W., Prain, K.M., Waters, P., Woodhall, M., O‘Gorman, C.M., Clarke, L., Silvestrini, R.A., Bundell, C.S., Abernethy, D., Bhuta, S., Blum, S., Boggild, M., Boundy, K., Brew, B.J., Brown, M., Brownlee, W.J., Butzkueven, H., Carroll, W.M., Chen, C., Coulthard, A., Dale, R.C., Das, C., Dear, K., Fabis-Pedrini, M.J., Fulcher, D., Gillis, D., Hawke, S., Heard, R., Henderson, A.P.D., Heshmat, S., Hodgkinson, S., Jimenez-Sanchez, S., Killpatrick, T., King, J., Kneebone, C., Kornberg, A.J., Lechner-Scott, J., Lin, M., Lynch, C., Macdonell, R., Mason, D.F., McCombe, P.A., Pender, M.P., Pereira, J.A., Pollard, J.D., Reddel, S.W., Shaw, C., Spies, J., Stankovich, J., Sutton, I., Vucic, S., Walsh, M., Wong, R.C., Yiu, E.M., Barnett, M.H., Kermode, A.G., Marriott, M.P., Parratt, J.D.E., Slee, M., Taylor, B.V., Willoughby, E., Wilson, R.J., Vincent, A., and Broadley, S.A.

Abstract

OBJECTIVES: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. BACKGROUND: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. METHODS: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture-recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases. RESULTS: NMOSD was confirmed in 81/170 (48%) cases referred. Capture-recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD. CONCLUSIONS: NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.

Published
2017

46. Measurement of D-meson production versus multiplicity in p-Pb collisions at root s(NN)=5.02 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aiola, S., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Alfaro Molina, R., Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Alves Garcia Prado, C., Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Arnaldi, R., Arnold, O. W., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Balasubramanian, S., Baldisseri, A., Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Bello Martinez, H., Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Benacek, P., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biro, G., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Bourjau, C., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Butt, J. B., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Calvo Villar, E., Camerini, P., Carena, F., Carena, W., Carnesecchi, F., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Ceballos Sanchez, C., Cerello, P., Cerkala, J., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chauvin, A., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Cho, S., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Cortes Maldonado, I., Cortese, P., Cosentino, M. R., Costa, F., Crochet, P., Cruz Albino, R., Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Conti, C., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., Deisting, A., Deloff, A., Denes, E., Deplano, C., Dhankher, P., Di Bari, D., Di Mauro, A., Di Nezza, P., Diaz Corchero, M. A., Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Domenicis Gimenez, D., Doenigus, B., Dordic, O., Drozhzhova, T., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Endress, E., Engel, H., Epple, E., Erazmus, B., Erdemir, I., Erhardt, F., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Feliciello, A., Feofilov, G., Ferencei, J., Fernandez Tellez, A., Ferreiro, E. G., Ferretti, A., Festanti, A., Feuillard, V. J. 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Abstract

The measurement of prompt D-meson production as a function of multiplicity in p-Pb collisions at TeV with the ALICE detector at root s(NN) the LHC is reported. D-0, D+ and Dau+ mesons are reconstructed via their hadronic decay channels in the centre-of-mass rapidity range -0.96

Published
2016

47. Multiplicity dependence of charged pion, kaon, and (anti)proton production at large transverse momentum in p-Pb collisions root S-NN=5.02 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahmad, S., Ahn, S. U., Aiola, S., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Alfaro Molina, R., Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Alves Garcia Prado, C., Andrei, C., Andronic, A., Anguelov, V., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Arnaldi, R., Arnold, O. W., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Balasubramanian, S., Baldisseri, A., Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Benacek, R., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Biecik, J., Bielcikova, J., Bilandzic, A., Biro, G., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Bourjau, C., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. 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Abstract

The production of charged pions, kaons and (anti)protons has been measured at mid-rapidity (-0.5 10 GeV/c), the particle ratios are consistent with those reported for pp and Pb-Pb collisions at the LHC energies. At intermediate p(T) the (anti)proton R-ppb shows a Cronin-like enhancement, while pions and kaons show little or no nuclear modification. At high p(T) the charged pion, kaon and (anti)proton R-ppb are consistent with unity within statistical and systematic uncertainties. (C) 2016 The Author. Published by Elsevier B.V.

Published
2016

48. Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Alves Garcia Prado, C., Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, R., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Armesto, N., Arnaldi, R., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Bara, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoeldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Boettger, S., Braun-Munzinger, R., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. 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S., Zhalov, M., Zhang, H., Zhang, X., Zhang, Y., Zhao, C., Zhigareva, N., Zhou, D., Zhou, Y., Zhou, Z., Zhu, H., Zhu, J., Zhu, X., Zichichi, A., Zimmermann, A., Zimmermann, M. B., Zinovjev, G., and Zyzak, M.

Abstract

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.

Published
2016

49. Centrality dependence of pion freeze-out radii in Pb-Pb collisions at root s(NN)=2.76 TeV

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahammed, Z., Ahn, S. U., Aimo, I., Aiola, S., Ajaz, M., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Prado, C. Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Armesto, N., Arnaldi, R., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoedi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blanco, F., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Boettger, S., Braun-Munzinger, P., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Bruna, E., Bruno, G. E., Budnikov, D., Buesching, H., Bufalino, S., Buncic, P., Busch, O., Buthelezi, Z., Butt, J. B., Buxton, J. T., Caffarri, D., Cai, X., Caines, H., Diaz, L. Calero, Caliva, A., Villar, E. Calvo, Camerini, P., Carena, F., Carena, W., Carnesecchi, F., Castellanos, J. Castillo, Castro, A. J., Casula, E. A. R., Cavicchioli, C., Sanchez, C. Ceballos, Cepila, J., Cerello, P., Cerkala, J., Chang, B., Chapeland, S., Chartier, M., Charvet, J. L., Chattopadhyay, S., Chelnokov, V., Cherney, M., Cheshkov, C., Cheynis, B., Barroso, V. Chibante, Chinellato, D. D., Chochula, P., Choi, K., Chojnacki, M., Choudhury, S., Christakoglou, P., Christensen, C. H., Christiansen, P., Chujo, T., Chung, S. U., Chunhui, Z., Cicalo, C., Cifarelli, L., Cindolo, F., Cleymans, J., Colamaria, F., Colella, D., Collu, A., Colocci, M., Balbastre, G. Conesa, Del Valle, Z. Conesa, Connors, M. E., Contreras, J. G., Cormier, T. M., Morales, Y. Corrales, Maldonado, I. Cortes, Cortese, P., Cosentino, M. R., Costa, F., Crochet, P., Albino, R. Cruz, Cuautle, E., Cunqueiro, L., Dahms, T., Dainese, A., Danu, A., Das, D., Das, I., Das, S., Dash, A., Dash, S., De, S., De Caro, A., de Cataldo, G., de Cuveland, J., De Falco, A., De Gruttola, D., De Marco, N., De Pasquale, S., Deisting, A., Deloff, A., Denes, E., D'Erasmo, G., Di Bari, D., Di Mauro, A., Di Nezza, P., Corchero, M. A. Diaz, Dietel, T., Dillenseger, P., Divia, R., Djuvsland, O., Dobrin, A., Dobrowolski, T., Gimenez, D. Domenicis, Doenigus, B., Dordic, O., Drozhzhova, T., Dubey, A. K., Dubla, A., Ducroux, L., Dupieux, P., Ehlers, R. J., Elia, D., Engel, H., Erazmus, B., Erdemir, I., Erhardt, F., Eschweiler, D., Espagnon, B., Estienne, M., Esumi, S., Eum, J., Evans, D., Evdokimov, S., Eyyubova, G., Fabbietti, L., Fabris, D., Faivre, J., Fantoni, A., Fasel, M., Feldkamp, L., Felea, D., Feliciello, A., Feofilov, G., Ferencei, J., Tellez, A. Fernandez, Ferreiro, E. G., Ferretti, A., Festanti, A., Feuillard, V. J. G., Figiel, J., Figueredo, M. A. S., Filchagin, S., Finogeev, D., Fiore, E. M., Fleck, M. G., Floris, M., Foertsch, S., Foka, P., Fokin, S., Fragiacomo, E., Francescon, A., Frankenfeld, U., Fuchs, U., Furget, C., Furs, A., Girard, M. Fusco, Gaardhoje, J. J., Gagliardi, M., Gago, A. M., Gallio, M., Gangadharan, D. R., Ganoti, P., Gao, C., Garabatos, C., Garcia-Solis, E., Gargiulo, C., Gasik, P., Germain, M., Gheata, A., Gheata, M., Ghosh, P., Ghosh, S. K., Gianotti, P., Giubellino, P., Giubilato, P., Gladysz-Dziadus, E., Glaessel, P., Coral, D. M. Gomez, Ramirez, A. Gomez, Gonzalez-Zamora, P., Gorbunov, S., Goerlich, L., Gotovac, S., Grabski, V., Graczykowski, L. K., Graham, K. L., Grelli, A., Grigoras, A., Grigoras, C., Grigoriev, V., Grigoryan, A., Grigoryan, S., Grinyov, B., Grion, N., Grosse-Oetringhaus, J. F., Grossiord, J. -Y., Grosso, R., Guber, F., Guernane, R., Guerzoni, B., Gulbrandsen, K., Gulkanyan, H., Gunji, T., Gupta, A., Gupta, R., Haake, R., Haaland, O., Hadjidakis, C., Haiduc, M., Hamagaki, H., Hamar, G., Hansen, A., Harris, J. W., Hartmann, H., Harton, A., Hatzifotiadou, D., Hayashi, S., Heckel, S. T., Heide, M., Helstrup, H., Herghelegiu, A., Corral, G. Herrera, Hess, B. A., Hetland, K. F., Hilden, T. E., Hillemanns, H., Hippolyte, B., Hosokawa, R., Hristov, P., Huang, M., Humanic, T. J., Hussain, N., Hussain, T., Hutter, D., Hwang, D. S., Ilkaev, R., Ilkiv, I., Inaba, M., Ippolitov, M., Irfan, M., Ivanov, M., Ivanov, V., Izucheev, V., Jacobs, P. M., Jadlovska, S., Jahnke, C., Jang, H. J., Janik, M. A., Jayarathna, P. H. S. Y., Jena, C., Jena, S., Bustamante, R. T. Jimenez, Jones, P. G., Jung, H., Jusko, A., Kalinak, P., Kalweit, A., Kamin, J., Kang, J. H., Kaplin, V., Kar, S., Uysal, A. Karasu, Karavichev, O., Karavicheva, T., Karayan, L., Karpechev, E., Kebschull, U., Keidel, R., Keijdener, D. L. D., Keil, M., Khan, K. H., Khan, M. M., Khan, P., Khan, S. A., Khanzadeev, A., Kharlov, Y., Kileng, B., Kim, B., Kim, D. W., Kim, D. J., Kim, H., Kim, J. S., Kim, M., Kim, S., Kim, T., Kirsch, S., Kisel, I., Kiselev, S., Kisiel, A., Kiss, G., Klay, J. L., Klein, C., Klein, J., Klein-Boesing, C., Kluge, A., Knichel, M. L., Knospe, A. G., Kobayashi, T., Kobdaj, C., Kofarago, M., Kollegger, T., Kolojvari, A., Kondratiev, V., Kondratyeva, N., Kondratyuk, E., Konevskikh, A., Kopcik, M., Kour, M., Kouzinopoulos, C., Kovalenko, O., Kovalenko, V., Kowalski, M., Meethaleveedu, G. Koyithatta, Kral, J., Kralik, I., Kravcakova, A., Krelina, M., Kretz, M., Krivda, M., Krizek, F., Kryshen, E., Krzewicki, M., Kubera, A. M., Kucera, V., Kugathasan, T., Kuhn, C., Kuijer, P. G., Kulakov, I., Kumar, A., Kumar, J., Kumar, L., Kurashvili, P., Kurepin, A., Kurepin, A. B., Kuryakin, A., Kushpil, S., Kweon, M. J., Kwon, Y., La Pointe, S. L., La Rocca, P., Fernandes, C. Lagana, Lakomov, I., Langoy, R., Lara, C., Lardeux, A., Lattuca, A., Laudi, E., Lea, R., Leardini, L., Lee, G. R., Lee, S., Legrand, I., Lehas, F., Lemmon, R. C., Lenti, V., Leogrande, E., Monzon, I. Leon, Leoncino, M., Levai, P., Li, S., Li, X., Lien, J., Lietava, R., Lindal, S., Lindenstruth, V., Lippmann, C., Lisa, M. A., Ljunggren, H. M., Lodato, D. F., Loenne, P. I., Loginov, V., Loizides, C., Lopez, X., Torres, E. Lopez, Lowe, A., Luettig, P., Lunardon, M., Luparello, G., Luz, P. H. F. N. D., Maevskaya, A., Mager, M., Mahajan, S., Mahmood, S. M., Maire, A., Majka, R. D., Malaev, M., Cervantes, I. Maldonado, Malinina, L., Mal'Kevich, D., Malzacher, P., Mamonov, A., Manko, V., Manso, F., Manzari, V., Marchisone, M., Mares, J., Margagliotti, G. V., Margotti, A., Margutti, J., Marin, A., Markert, C., Marquard, M., Martin, N. A., Blanco, J. Martin, Martinengo, P., Martinez, M. I., Garcia, G. Martinez, Pedreira, M. Martinez, Martynov, Y., Mas, A., Masciocchi, S., Masera, M., Masoni, A., Massacrier, L., Mastroserio, A., Masui, H., Matyja, A., Mayer, C., Mazer, J., Mazzoni, M. A., Mcdonald, D., Meddi, F., Melikyan, Y., Menchaca-Rocha, A., Meninno, E., Perez, J. Mercado, Meres, M., Miake, Y., Mieskolainen, M. M., Mikhaylov, K., Milano, L., Milosevic, J., Minervini, L. M., Mischke, A., Mishra, A. N., Miskowiec, D., Mitra, J., Mitu, C. M., Mohammadi, N., Mohanty, B., Molnar, L., Zetina, L. Montano, Montes, E., Morando, M., De Godoy, D. A. Moreira, Moretto, S., Morreale, A., Morsch, A., Muccifora, V., Mudnic, E., Muehlheim, D., Muhuri, S., Mukherjee, M., Mulligan, J. D., Munhoz, M. G., Murray, S., Musa, L., Musinsky, J., Nandi, B. K., Nania, R., Nappi, E., Naru, M. U., Nattrass, C., Nayak, K., Nayak, T. K., Nazarenko, S., Nedosekin, A., Nellen, L., Ng, F., Nicassio, M., Niculescu, M., Niedziela, J., Nielsen, B. 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Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, P., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Armesto, N., Arnaldi, R., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Bach, M., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Pedrosa, F. Baltasar Dos Santos, Baral, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoedi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basu, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Bedda, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. 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S., Zhalov, M., Zhang, H., Zhang, X., Zhang, Y., Zhao, C., Zhigareva, N., Zhou, D., Zhou, Y., Zhou, Z., Zhu, H., Zhu, J., Zhu, X., Zichichi, A., Zimmermann, A., Zimmermann, M. B., Zinovjev, G., and Zyzak, M.

Abstract

We report on the measurement of freeze-out radii for pairs of identical-charge pions measured in Pb-Pb collisions at root s(NN) = 2.76 TeV as a function of collision centrality and the average transverse momentum of the pair k(T). Three-dimensional sizes of the system (femtoscopic radii), as well as direction-averaged one-dimensional radii are extracted. The radii decrease with k(T), following a power-law behavior. This is qualitatively consistent with expectations from a collectively expanding system, produced in hydrodynamic calculations. The radii also scale linearly with (1/3). This behavior is compared to world data on femtoscopic radii in heavy-ion collisions. While the dependence is qualitatively similar to results at smaller root s(NN), a decrease in the ratio R-out/R-side is seen, which is in qualitative agreement with a specific prediction from hydrodynamic models: a change from inside-out to outside-in freeze-out configuration. The results provide further evidence for the production of a collective, strongly coupled system in heavy-ion collisions at the CERN Large Hadron Collider.

Published
2016

50. Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

Author

University of Helsinki, Helsinki Institute of Physics, University of Helsinki, Department of Physics, University of Helsinki, Helsinki Institute of Physics (HIP) (-2009), Adam, J., Adamova, D., Aggarwal, M. M., Rinella, G. Aglieri, Agnello, M., Agrawal, N., Ahmmed, Z., Ahn, S. U., Aiola, S., Akindinov, A., Alam, S. N., Aleksandrov, D., Alessandro, B., Alexandre, D., Molina, R. Alfaro, Alici, A., Alkin, A., Almaraz, J. R. M., Alme, J., Alt, T., Altinpinar, S., Altsybeev, I., Prado, C. Alves Garcia, Andrei, C., Andronic, A., Anguelov, V., Anielski, J., Anticic, T., Antinori, F., Antonioli, R., Aphecetche, L., Appelshaeuser, H., Arcelli, S., Arnaldi, R., Arnold, O. W., Arsene, I. C., Arslandok, M., Audurier, B., Augustinus, A., Averbeck, R., Azmi, M. D., Badala, A., Baek, Y. W., Bagnasco, S., Bailhache, R., Bala, R., Baldisseri, A., Bara, R. C., Barbano, A. M., Barbera, R., Barile, F., Barnafoeldi, G. G., Barnby, L. S., Barret, V., Bartalini, P., Barth, K., Bartke, J., Bartsch, E., Basile, M., Bastid, N., Basil, S., Bathen, B., Batigne, G., Camejo, A. Batista, Batyunya, B., Batzing, P. C., Bearden, I. G., Beck, H., Beddall, C., Behera, N. K., Belikov, I., Bellini, F., Martinez, H. Bello, Bellwied, R., Belmont, R., Belmont-Moreno, E., Belyaev, V., Bencedi, G., Beole, S., Berceanu, I., Bercuci, A., Berdnikov, Y., Berenyi, D., Bertens, R. A., Berzano, D., Betev, L., Bhasin, A., Bhat, I. R., Bhati, A. K., Bhattacharjee, B., Bhom, J., Bianchi, L., Bianchi, N., Bianchin, C., Bielcik, J., Bielcikova, J., Bilandzic, A., Biswas, R., Biswas, S., Bjelogrlic, S., Blair, J. T., Blau, D., Blume, C., Bock, F., Bogdanov, A., Boggild, H., Boldizsar, L., Bombara, M., Book, J., Borel, H., Borissov, A., Borri, M., Bossu, F., Botta, E., Boettger, S., Bourjau, C., Braun-Munzinger, R., Bregant, M., Breitner, T., Broker, T. A., Browning, T. A., Broz, M., Brucken, E. J., Brunall, E., Bruno, G. 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Abstract

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20

Published
2016

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