5 results on '"Bodenreider O"'
Search Results
2. Alignment of the UMLS semantic network with BioTop: Methodology and assessment
- Author
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Schulz, S., Beisswanger, E. (Elena), Hoek, L. (László) van den, Bodenreider, O. (Olivier), Mulligen, E.M. (Erik) van, Schulz, S., Beisswanger, E. (Elena), Hoek, L. (László) van den, Bodenreider, O. (Olivier), and Mulligen, E.M. (Erik) van
- Abstract
Motivation: For many years, the Unified Medical Language System (UMLS) semantic network (SN) has been used as an upper-level semantic framework for the categorization of terms from terminological resources in biomedicine. BioTop has recently been developed as an upper-level ontology for the biomedical domain. In contrast to the SN, it is founded upon strict ontological principles, using OWL DL as a formal representation language, which has become standard in the semantic Web. In order to make logic-based reasoning available for the resources annotated or categorized with the SN, a mapping ontology was developed aligning the SN with BioTop. Methods: The theoretical foundations and the practical realization of the alignment are being described, with a focus on the design decisions taken, the problems encountered and the adaptations of BioTop that became necessary. For evaluation purposes, UMLS concept pairs obtained from MEDLINE abstracts by a named entity recognition system were tested for possible semantic relationships. Furthermore, all semantic-type combinations that occur in the UMLS Metathesaurus were checked for satisfiability. Results: The effort-intensive alignment process required major design changes and enhancements of BioTop and brought up se
- Published
- 2009
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3. Alignment of the UMLS semantic network with BioTop: methodology and assessment
- Author
-
Schulz, S, Beisswanger, E, van den Hoek, L (László), Bodenreider, O, van Mulligen, Erik, Schulz, S, Beisswanger, E, van den Hoek, L (László), Bodenreider, O, and van Mulligen, Erik
- Abstract
Motivation: For many years, the Unified Medical Language System (UMLS) semantic network (SN) has been used as an upper-level semantic framework for the categorization of terms from terminological resources in biomedicine. BioTop has recently been developed as an upper-level ontology for the biomedical domain. In contrast to the SN, it is founded upon strict ontological principles, using OWL DL as a formal representation language, which has become standard in the semantic Web. In order to make logic-based reasoning available for the resources annotated or categorized with the SN, a mapping ontology was developed aligning the SN with BioTop. Methods: The theoretical foundations and the practical realization of the alignment are being described, with a focus on the design decisions taken, the problems encountered and the adaptations of BioTop that became necessary. For evaluation purposes, UMLS concept pairs obtained from MEDLINE abstracts by a named entity recognition system were tested for possible semantic relationships. Furthermore, all semantic-type combinations that occur in the UMLS Metathesaurus were checked for satisfiability. Results: The effort-intensive alignment process required major design changes and enhancements of BioTop and brought up several design errors that could be fixed. A comparison between a human curator and the ontology yielded only a low agreement. Ontology reasoning was also used to successfully identify 133 inconsistent semantic-type combinations.
- Published
- 2009
4. Advancing translational research with the Semantic Web
- Author
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Ruttenberg, A., Clark, T. (Tim), Bug, W., Samwald, M., Bodenreider, O., Doherty, D., Chen, H. (Helen), Forsberg, K., Gao, Y., Kashyap, V., Kinoshita, J., Luciano, J., Marshall, M.S. (Scott), Ogbuji, C., Rees, J. (Jonathan), Stephens, S., Wu, E. (Elizabeth), Zaccagninni, D., Hongsermeier, T., Neumann, E., Herman, I. (Ivan), Cheung, K.-H., Ruttenberg, A., Clark, T. (Tim), Bug, W., Samwald, M., Bodenreider, O., Doherty, D., Chen, H. (Helen), Forsberg, K., Gao, Y., Kashyap, V., Kinoshita, J., Luciano, J., Marshall, M.S. (Scott), Ogbuji, C., Rees, J. (Jonathan), Stephens, S., Wu, E. (Elizabeth), Zaccagninni, D., Hongsermeier, T., Neumann, E., Herman, I. (Ivan), and Cheung, K.-H.
- Abstract
A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to translational research is the lack of uniformly structured data across related biomedical domains. The Semantic Web is an extension of the current Web that enables navigation and meaningful use of digital resources by automatic processes. It is based on common formats that support aggregation and integration of data drawn from diverse sources. A variety of technologies have been built on this foundation that, together, support identifying, representing, and reasoning across a wide range of biomedical data. The Semantic Web Health Care and Life Sciences Interest Group (HCLSIG), set up within the framework of the World Wide Web Consortium, was launched to explore the application of these technologies in a variety of areas. Subgroups focus on making biomedical data available in RDF, working with biomedical ontologies, prototyping clinical decision support systems, working on drug safety and efficacy communication, and supporting disease researchers navigating and annotating the large amount of potentially relevant literature.
- Published
- 2007
5. Advancing translational research with the Semantic Web
- Author
-
Ruttenberg, A., Clark, T. (Tim), Bug, W., Samwald, M., Bodenreider, O., Doherty, D., Chen, H. (Helen), Forsberg, K., Gao, Y., Kashyap, V., Kinoshita, J., Luciano, J., Marshall, M.S. (Scott), Ogbuji, C., Rees, J. (Jonathan), Stephens, S., Wu, E. (Elizabeth), Zaccagninni, D., Hongsermeier, T., Neumann, E., Herman, I. (Ivan), Cheung, K.-H., Ruttenberg, A., Clark, T. (Tim), Bug, W., Samwald, M., Bodenreider, O., Doherty, D., Chen, H. (Helen), Forsberg, K., Gao, Y., Kashyap, V., Kinoshita, J., Luciano, J., Marshall, M.S. (Scott), Ogbuji, C., Rees, J. (Jonathan), Stephens, S., Wu, E. (Elizabeth), Zaccagninni, D., Hongsermeier, T., Neumann, E., Herman, I. (Ivan), and Cheung, K.-H.
- Abstract
A fundamental goal of the U.S. National Institute of Health (NIH) "Roadmap" is to strengthen Translational Research, defined as the movement of discoveries in basic research to application at the clinical level. A significant barrier to translational research is the lack of uniformly structured data across related biomedical domains. The Semantic Web is an extension of the current Web that enables navigation and meaningful use of digital resources by automatic processes. It is based on common formats that support aggregation and integration of data drawn from diverse sources. A variety of technologies have been built on this foundation that, together, support identifying, representing, and reasoning across a wide range of biomedical data. The Semantic Web Health Care and Life Sciences Interest Group (HCLSIG), set up within the framework of the World Wide Web Consortium, was launched to explore the application of these technologies in a variety of areas. Subgroups focus on making biomedical data available in RDF, working with biomedical ontologies, prototyping clinical decision support systems, working on drug safety and efficacy communication, and supporting disease researchers navigating and annotating the large amount of potentially relevant literature.
- Published
- 2007
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