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1. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alnæs, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Bøen, E, Breukelaar, IA ; https://orcid.org/0000-0002-6241-5274, Bright, JK, Buimer, EEL, Bülow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivières, S, Díaz-Caneja, CM, Doan, NT, Dohm, K, Fröhner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J ; https://orcid.org/0000-0002-2147-6302, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Mühleisen, TW, Nabulsi, L, Opel, N, de la Foz, VOG, Overs, BJ ; https://orcid.org/0000-0002-7138-5556, Paillère Martinot, ML, Redlich, R, Marques, TR, Repple, J, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A ; https://orcid.org/0000-0002-7114-1260, Tordesillas-Gutiérrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W ; https://orcid.org/0000-0003-2753-3870, Westeneng, HJ, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Peñas, J, Trollor, Julian ; https://orcid.org/0000-0002-7685-2977, Fullerton, Janice ; https://orcid.org/0000-0003-4014-4490, Schofield, Peter ; https://orcid.org/0000-0003-2967-9662, Mather, Karen ; https://orcid.org/0000-0003-4143-8941, Brodaty, Henry ; https://orcid.org/0000-0001-9487-6617, Sachdev, Perminder ; https://orcid.org/0000-0002-9595-3220, Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235, Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alnæs, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Bøen, E, Breukelaar, IA ; https://orcid.org/0000-0002-6241-5274, Bright, JK, Buimer, EEL, Bülow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivières, S, Díaz-Caneja, CM, Doan, NT, Dohm, K, Fröhner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J ; https://orcid.org/0000-0002-2147-6302, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Mühleisen, TW, Nabulsi, L, Opel, N, de la Foz, VOG, Overs, BJ ; https://orcid.org/0000-0002-7138-5556, Paillère Martinot, ML, Redlich, R, Marques, TR, Repple, J, Roberts, G ; https://orcid.org/0000-0002-1966-5120, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A ; https://orcid.org/0000-0002-7114-1260, Tordesillas-Gutiérrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W ; https://orcid.org/0000-0003-2753-3870, Westeneng, HJ, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Peñas, J, Trollor, Julian ; https://orcid.org/0000-0002-7685-2977, Fullerton, Janice ; https://orcid.org/0000-0003-4014-4490, Schofield, Peter ; https://orcid.org/0000-0003-2967-9662, Mather, Karen ; https://orcid.org/0000-0003-4143-8941, Brodaty, Henry ; https://orcid.org/0000-0001-9487-6617, Sachdev, Perminder ; https://orcid.org/0000-0002-9595-3220, and Mitchell, Philip ; https://orcid.org/0000-0002-7954-5235

Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Published
2022

2. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alanaes, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Boen, E, Breukelaar, IA, Bright, JK, Buimer, EEL, Bulow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivieres, S, Diaz-Caneja, CM, Doan, NT, Dohm, K, Froehner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Muehleisen, TW, Nabulsi, L, Opel, N, de la Foz, VO-G, Overs, BJ, Paillere Martinot, M-L, Redlich, R, Marques, TR, Repple, J, Roberts, G, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A, Tordesillas-Gutierrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W, Westeneng, H-J, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Penas, J, Guimaraes, JPOFT, Homuth, G, Hottenga, J-J, Knol, MJ, Kwok, JBJ, Le Hellard, S, Mather, KA, Milaneschi, Y, Morris, DW, Noethen, MM, Papiol, S, Rietschel, M, Santoro, ML, Steen, VM, Stein, JL, Streit, F, Tankard, RM, Teumer, A, van 't Ent, D, van der Meer, D, van Eijk, KR, Vassos, E, Vazquez-Bourgon, J, Witt, SH, Adams, HHH, Agartz, I, Ames, D, Amunts, K, Andreassen, OA, Arango, C, Banaschewski, T, Baune, BT, Belangero, SI, Bokde, ALW, Boomsma, DI, Bressan, RA, Brodaty, H, Buitelaar, JK, Cahn, W, Caspers, S, Cichon, S, Crespo-Facorro, B, Cox, SR, Dannlowski, U, Elvsashagen, T, Espeseth, T, Falkai, PG, Fisher, SE, Flor, H, Fullerton, JM, Garavan, H, Gowland, PA, Grabe, HJ, Hahn, T, Heinz, A, Hillegers, M, Hoare, J, Hoekstra, PJ, Ikram, MA, Jackowski, AP, Jansen, A, Jonsson, EG, Kahn, RS, Kircher, T, Korgaonkar, MS, Krug, A, Lemaitre, H, Malt, UF, Martinot, J-L, McDonald, C, Mitchell, PB, Muetzel, RL, Murray, RM, Nees, F, Nenadic, I, Oosterlaan, J, Ophoff, RA, Pan, PM, Penninx, BWJH, Poustka, L, Sachdev, PS, Salum, GA, Schofield, PR, Schumann, G, Shaw, P, Sim, K, Smolka, MN, Stein, DJ, Trollor, JN, van den Berg, LH, Veldink, JH, Walter, H, Westlye, LT, Whelan, R, White, T, Wright, MJ, Medland, SE, Franke, B, Thompson, PM, Hulshoff Pol, HE, Brouwer, RM, Klein, M, Grasby, KL, Schnack, HG, Jahanshad, N, Teeuw, J, Thomopoulos, SI, Sprooten, E, Franz, CE, Gogtay, N, Kremen, WS, Panizzon, MS, Olde Loohuis, LM, Whelan, CD, Aghajani, M, Alloza, C, Alanaes, D, Artiges, E, Ayesa-Arriola, R, Barker, GJ, Bastin, ME, Blok, E, Boen, E, Breukelaar, IA, Bright, JK, Buimer, EEL, Bulow, R, Cannon, DM, Ciufolini, S, Crossley, NA, Damatac, CG, Dazzan, P, de Mol, CL, de Zwarte, SMC, Desrivieres, S, Diaz-Caneja, CM, Doan, NT, Dohm, K, Froehner, JH, Goltermann, J, Grigis, A, Grotegerd, D, Han, LKM, Harris, MA, Hartman, CA, Heany, SJ, Heindel, W, Heslenfeld, DJ, Hohmann, S, Ittermann, B, Jansen, PR, Janssen, J, Jia, T, Jiang, J, Jockwitz, C, Karali, T, Keeser, D, Koevoets, MGJC, Lenroot, RK, Malchow, B, Mandl, RCW, Medel, V, Meinert, S, Morgan, CA, Muehleisen, TW, Nabulsi, L, Opel, N, de la Foz, VO-G, Overs, BJ, Paillere Martinot, M-L, Redlich, R, Marques, TR, Repple, J, Roberts, G, Roshchupkin, GV, Setiaman, N, Shumskaya, E, Stein, F, Sudre, G, Takahashi, S, Thalamuthu, A, Tordesillas-Gutierrez, D, van der Lugt, A, van Haren, NEM, Wardlaw, JM, Wen, W, Westeneng, H-J, Wittfeld, K, Zhu, AH, Zugman, A, Armstrong, NJ, Bonfiglio, G, Bralten, J, Dalvie, S, Davies, G, Di Forti, M, Ding, L, Donohoe, G, Forstner, AJ, Gonzalez-Penas, J, Guimaraes, JPOFT, Homuth, G, Hottenga, J-J, Knol, MJ, Kwok, JBJ, Le Hellard, S, Mather, KA, Milaneschi, Y, Morris, DW, Noethen, MM, Papiol, S, Rietschel, M, Santoro, ML, Steen, VM, Stein, JL, Streit, F, Tankard, RM, Teumer, A, van 't Ent, D, van der Meer, D, van Eijk, KR, Vassos, E, Vazquez-Bourgon, J, Witt, SH, Adams, HHH, Agartz, I, Ames, D, Amunts, K, Andreassen, OA, Arango, C, Banaschewski, T, Baune, BT, Belangero, SI, Bokde, ALW, Boomsma, DI, Bressan, RA, Brodaty, H, Buitelaar, JK, Cahn, W, Caspers, S, Cichon, S, Crespo-Facorro, B, Cox, SR, Dannlowski, U, Elvsashagen, T, Espeseth, T, Falkai, PG, Fisher, SE, Flor, H, Fullerton, JM, Garavan, H, Gowland, PA, Grabe, HJ, Hahn, T, Heinz, A, Hillegers, M, Hoare, J, Hoekstra, PJ, Ikram, MA, Jackowski, AP, Jansen, A, Jonsson, EG, Kahn, RS, Kircher, T, Korgaonkar, MS, Krug, A, Lemaitre, H, Malt, UF, Martinot, J-L, McDonald, C, Mitchell, PB, Muetzel, RL, Murray, RM, Nees, F, Nenadic, I, Oosterlaan, J, Ophoff, RA, Pan, PM, Penninx, BWJH, Poustka, L, Sachdev, PS, Salum, GA, Schofield, PR, Schumann, G, Shaw, P, Sim, K, Smolka, MN, Stein, DJ, Trollor, JN, van den Berg, LH, Veldink, JH, Walter, H, Westlye, LT, Whelan, R, White, T, Wright, MJ, Medland, SE, Franke, B, Thompson, PM, and Hulshoff Pol, HE

Abstract

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.

Published
2022

3. Sub-picosecond exchange-relaxation in the compensated ferrimagnet Mn2RuxGa

Author

Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., Kirilyuk, A.I., Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., and Kirilyuk, A.I.

Abstract

Contains fulltext : 230606.pdf (publisher's version ) (Open Access)

Published
2021

4. Sub-picosecond exchange-relaxation in the compensated ferrimagnet Mn2RuxGa

Author

Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., Kirilyuk, A.I., Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., and Kirilyuk, A.I.

Abstract

Contains fulltext : 230606.pdf (publisher's version ) (Open Access)

Published
2021

5. Sub-picosecond exchange-relaxation in the compensated ferrimagnet Mn2RuxGa

Author

Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., Kirilyuk, A.I., Bonfiglio, G., Rode, K., Atcheson, G.Y.P., Stamenov, P., Coey, J.M.D., Kimel, A.V., Rasing, T.H.M., and Kirilyuk, A.I.

Abstract

Contains fulltext : 230606.pdf (publisher's version ) (Open Access)

Published
2021

7. Exchange-driven all-optical magnetic switching in compensated 3d ferrimagnets

Author

Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., Kirilyuk, A., Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., and Kirilyuk, A.

Abstract

Contains fulltext : 227104.pdf (publisher's version ) (Open Access)

Published
2020

8. Exchange-driven all-optical magnetic switching in compensated 3d ferrimagnets

Author

Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., Kirilyuk, A., Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., and Kirilyuk, A.

Abstract

Contains fulltext : 227104.pdf (publisher's version ) (Open Access)

Published
2020

9. Exchange-driven all-optical magnetic switching in compensated 3d ferrimagnets

Author

Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., Kirilyuk, A., Davies, C.S., Bonfiglio, G., Rode, K., Besbas, J., Banerjee, C., Stamenov, P., Coey, J.M.D., Kimel, A.V., and Kirilyuk, A.

Abstract

Contains fulltext : 227104.pdf (publisher's version ) (Open Access)

Published
2020

10. In vitro activity of a new quinolone, rufloxacin, against nosocomial isolates

Author

Mattina, R, Cocuzza, C, Cesana, M, Bonfiglio, G, Bonfiglio, G., COCUZZA, CLEMENTINA ELVEZIA, Mattina, R, Cocuzza, C, Cesana, M, Bonfiglio, G, Bonfiglio, G., and COCUZZA, CLEMENTINA ELVEZIA

Abstract

The in vitro activity of rufloxacin (MF 934), a new broad-spectrum fluoroquinolone, was tested against 1,032 gram-positive and gram-negative clinical isolates and compared to that of five other compounds of this class. All quinolones except for ciprofloxacin had limited activity against group A and B streptococci and pneumococci (MIC 90% of 4-64 mg/l) and no activity against enterococci. Most species of the enterobacteriaceae and staphylococci were found to be sensitive to rufloxacin (MIC 90% of 0.5-8 and 2-8 mg/l). Like the other quinolones except for ciprofloxacin, rufloxacin was not active against Pseudomonas aeruginosa. The antibacterial activity of rufloxacin was affected only minimally by an increase in the bacterial inoculum or by alterations in the pH of the medium. In spite of the relatively higher MICs of rufloxacin compared to those of the other quinolones, its favorable pharmacokinetic properties may account for its good clinical efficacy.

Published
1991

11. Datazione assoluta e caratterizzazione di laterizi e malte provenienti dal sito UNESCO di Modena

Author

Bonfiglio, G, Caroselli, M, Gueli, A, Heinemeier, J, Lindroos, A, Lubritto, C, Luglio, S, Marchetti Dori, S, Martini, M, Marzaioli, F, Nonni, S, Ringbom, A, Sibilia, E, Terrasi, F, Troja, S, Troja SO, MARTINI, MARCO, SIBILIA, EMANUELA, Bonfiglio, G, Caroselli, M, Gueli, A, Heinemeier, J, Lindroos, A, Lubritto, C, Luglio, S, Marchetti Dori, S, Martini, M, Marzaioli, F, Nonni, S, Ringbom, A, Sibilia, E, Terrasi, F, Troja, S, Troja SO, MARTINI, MARCO, and SIBILIA, EMANUELA

Published
2014

12. Pharmacokinetics of rufloxacin in healthy volunteers after repeated oral doses

Author

Mattina, R, Bonfiglio, G, Cocuzza, C, Gulisano, G, Cesana, M, Imbimbo, B, Imbimbo, BP, COCUZZA, CLEMENTINA ELVEZIA, Mattina, R, Bonfiglio, G, Cocuzza, C, Gulisano, G, Cesana, M, Imbimbo, B, Imbimbo, BP, and COCUZZA, CLEMENTINA ELVEZIA

Abstract

Rufloxacin is a new broad-spectrum fluoroquinolone antibacterial agent. The pharmacokinetics and safety of rufloxacin were evaluated after repeated oral administration to healthy volunteers. The drug was administered once a day for 6 consecutive days following two different dose schedules. The first group of 11 subjects was given a loading dose of 300 mg on the first day and 150 mg on the subsequent 5 days. The second group of 12 subjects was given a loading dose of 400 mg and 200 mg for 5 days. Serum levels and urine concentrations of rufloxacin were determined by microbiological assay. A simultaneous fit of all data points for each subject was done according to a one-compartment open model. The drug was rapidly absorbed (absorption half-life 17 +/- 6 min in the 300 + 150 mg and 11 +/- 5 min in the 400 + 200 mg dose regimen group) and reached maximal serum concentrations (2.77 +/- 0.24 and 3.62 +/- 0.35 micrograms/ml) 4.2 +/- 0.4 and 4.0 +/- 0.9 h after the first administration. Steady-state serum concentrations (3.19 +/- 0.31 and 4.06 +/- 0.33 micrograms/ml) were reached in 3.7 +/- 0.7 and 4.5 +/- 0.4 days. Elimination half-lives were 29.5 +/- 2.4 and 36.0 +/- 2.8 h. Apparent volumes of distribution were 111 +/- 8 and 136 +/- 16 liters and apparent plasma clearances were 46 +/- 5 and 44 +/- 4 ml/min. Renal clearances were 18 +/- 3 and 17 +/- 2 ml/min.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991

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