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1. ETS1 inactivation causes innate drug resistance to EGFR inhibitors.

Author

Tetsu, Osamu, Tetsu, Osamu, Phuchareon, Janyaporn, Eisele, David W, McCormick, Frank, Tetsu, Osamu, Tetsu, Osamu, Phuchareon, Janyaporn, Eisele, David W, and McCormick, Frank

Abstract

Mutations in epidermal growth factor receptor (EGFR) are found in approximately 10% of lung cancers. Treatment with EGFR inhibitors, although promising, has surprisingly resulted in greater than 90% tumor reduction in only 5% of cases, prompting us to investigate the mechanism of innate drug resistance.

Published
2016

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