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How ions are energized and heated is a fundamental problem in the study of energy dissipation in magnetized plasmas. In particular, the heating of heavy ions (including ${}^{4}\mathrm{He}^{2+}$, ${}^{3}\mathrm{He}^{2+}$ and others) has been a constant concern for understanding the microphysics of impulsive solar flares. In this article, via two-dimensional hybrid-kinetic Particle-in-Cell simulations, we study the heating of Helium ions (${}^{4}\mathrm{He}^{2+}$) by turbulence driven by cascading waves launched at large scales from the left-handed polarized Helium ion cyclotron wave branch of a multi-ion plasma composed of electrons, protons, and Helium ions. We find significant parallel (to the background magnetic field) heating for both Helium ions and protons due to the formation of beams and plateaus in their velocity distribution functions along the background magnetic field. The heating of Helium ions in the direction perpendicular to the magnetic field starts with a lower rate than that in the parallel direction, but overtakes the parallel heating after a few hundreds of the proton gyro-periods due to cyclotron resonances with mainly obliquely propagating waves induced by the cascade of injected Helium ion cyclotron waves at large scales. There is however little evidence for proton heating in the perpendicular direction due to the absence of left-handed polarized cyclotron waves near the proton cyclotron frequency. Our results are useful for understanding the preferential heating of ${}^{3}\mathrm{He}$ and other heavy ions in the ${}^{3}\mathrm{He}$-rich solar energetic particle events, in which Helium ions play a crucial role as a species of background ions regulating the kinetic plasma behavior., Comment: accepted by ApJ

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor’s RBCs have antigens missing on the recipient’s cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.

Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which may cause severe complications. The aim of this study was to describe available options and survey current practices by means of a questionnaire circulated within the EBMT Pediatric Diseases Working Party investigators. Major ABO incompatibility (donor’s RBCs have antigens missing on the recipient’s cell surface, towards which the recipient has circulating isohemagglutinins) requires most frequently an intervention in case of bone marrow grafts, as immediate or delayed hemolysis, delayed erythropoiesis and pure red cell aplasia may occur. RBC depletion from the graft (82%), recipient plasma-exchange (14%) were the most common practices, according to the survey. Graft manipulation is rarely needed in mobilized peripheral blood grafts. In case of minor incompatible grafts (donor has isohemagglutinins directed against recipient RBC antigens), isohemagglutinin depletion from the graft by plasma reduction/centrifugation may be considered, but acute tolerability of minor incompatible grafts is rarely an issue. According to the survey, minor ABO incompatibility was either managed by means of plasma removal from the graft, especially when isohemagglutinin titer was above a certain threshold, or led to no intervention at all (41%). Advantages and disadvantages of each method are discussed.

Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.

We analyzed properties of waves excited by mildly relativistic electron beams propagating along magnetic field with a ring-shape perpendicular momentum distribution in neutral and current-free solar coronal plasmas. These plasmas are subject to both the beam and the electron cyclotron maser (ECM) instabilities driven by the positive momentum gradient of the ring-beam electron distribution in the directions parallel and perpendicular to the ambient magnetic field, respectively. To explore the related kinetic processes self-consistently, 2.5-dimensional fully kinetic particle-in-cell (PIC) simulations were carried out. To quantify excited wave properties in different coronal conditions, we investigated the dependence of their energy and polarization on the ring-beam electron density and magnetic field. In general, electrostatic waves dominate the energetics of waves and nonlinear waves are ubiquitous. In weakly magnetized plasmas, where the electron cyclotron frequency $\omega_{ce}$ is lower than the electron plasma frequency $\omega_{pe}$, it is difficult to produce escaping electromagnetic waves with frequency $\omega > \omega_{pe}$ and small refractive index $|c k / \omega| < 1$ ($k$ and $c$ are the wavenumber and the light speed, respectively). Highly polarized and anisotropic escaping electromagnetic waves can, however, be effectively excited in strongly magnetized plasmas with $\omega_{ce}/\omega_{pe} \geq 1$. The anisotropy of the energy, circular polarization degree (CPD), and spectrogram of these escaping electromagnetic waves strongly depend on the number density ratio of the ring-beam electrons to the background electrons. In particular, their CPDs can vary from left-handed to right-handed with the decrease of the ring-beam density, which may explain some observed properties of solar radio bursts (e.g., radio spikes) from the solar corona., Comment: ApJ, accepted

We analyzed properties of waves excited by mildly relativistic electron beams propagating along magnetic field with a ring-shape perpendicular momentum distribution in neutral and current-free solar coronal plasmas. These plasmas are subject to both the beam and the electron cyclotron maser (ECM) instabilities driven by the positive momentum gradient of the ring-beam electron distribution in the directions parallel and perpendicular to the ambient magnetic field, respectively. To explore the related kinetic processes self-consistently, 2.5-dimensional fully kinetic particle-in-cell (PIC) simulations were carried out. To quantify excited wave properties in different coronal conditions, we investigated the dependence of their energy and polarization on the ring-beam electron density and magnetic field. In general, electrostatic waves dominate the energetics of waves and nonlinear waves are ubiquitous. In weakly magnetized plasmas, where the electron cyclotron frequency $\omega_{ce}$ is lower than the electron plasma frequency $\omega_{pe}$, it is difficult to produce escaping electromagnetic waves with frequency $\omega > \omega_{pe}$ and small refractive index $|c k / \omega| < 1$ ($k$ and $c$ are the wavenumber and the light speed, respectively). Highly polarized and anisotropic escaping electromagnetic waves can, however, be effectively excited in strongly magnetized plasmas with $\omega_{ce}/\omega_{pe} \geq 1$. The anisotropy of the energy, circular polarization degree (CPD), and spectrogram of these escaping electromagnetic waves strongly depend on the number density ratio of the ring-beam electrons to the background electrons. In particular, their CPDs can vary from left-handed to right-handed with the decrease of the ring-beam density, which may explain some observed properties of solar radio bursts (e.g., radio spikes) from the solar corona., Comment: ApJ, accepted

Although turbulence has been conjectured to be important for magnetic reconnection, still very little is known about its role in collisionless plasmas. Previous attempts to quantify the effect of turbulence on reconnection usually prescribed Alfv\'enic or other low-frequency fluctuations or investigated collisionless kinetic effects in just two-dimensional configurations and antiparallel magnetic fields. In view of this, we analyzed the kinetic turbulence self-generated by three-dimensional guide-field reconnection through force-free current sheets in frequency and wavenumber spaces, utilizing 3D particle-in-cell code numerical simulations. Our investigations reveal reconnection rates and kinetic turbulence with features similar to those obtained by current in-situ spacecraft observations of MMS as well as in the laboratory reconnection experiments MRX, VTF and \textsc{Vineta}-II. In particular we found that the kinetic turbulence developing in the course of 3D guide-field reconnection exhibits a broadband power-law spectrum extending beyond the lower-hybrid frequency and up to the electron frequencies. In the frequency space the spectral index of the turbulence appeared to be close to -2.8 at the reconnection X-line. In the wavenumber space it also becomes -2.8 as soon as the normalized reconnection rate reaches 0.1. The broadband kinetic turbulence is mainly due to current-streaming and electron-flow-shear instabilities excited in the sufficiently thin current sheets of kinetic reconnection. The growth of the kinetic turbulence corresponds to high reconnection rates which exceed those of fast laminar, non-turbulent reconnection., Comment: 13 pages, 10 figures. Revised version. Published in Physical Review E

We report a newly found two-stage mechanism of electron acceleration near X-lines of 3D collisionless guide-field magnetic reconnection in the non-relativistic regime typical, e.g., for stellar coronae. We found that after electrons are first pre-accelerated during the linear growth of reconnection, they become additionally accelerated in the course of the nonlinear stage of 3D guide-field magnetic reconnection. This additional acceleration is due to the filamentation of electric and magnetic fields caused by streaming instabilities. In addition to enhanced parallel electric fields, the filamentation leads to additional curvature-driven electron acceleration in the guide-field direction. As a result, part of the the accelerated electron spectra becomes a power law with a spectral index of $\sim-1.6$ near the X-line. This second stage of acceleration due to nonlinear reconnection is relevant for the production of energetic electrons in, e.g., thin current sheets of stellar coronae., Comment: 15 pages. 11 figures. Revised version. Published in The Astrophysical Journal

We report a newly found two-stage mechanism of electron acceleration near X-lines of 3D collisionless guide-field magnetic reconnection in the non-relativistic regime typical, e.g., for stellar coronae. We found that after electrons are first pre-accelerated during the linear growth of reconnection, they become additionally accelerated in the course of the nonlinear stage of 3D guide-field magnetic reconnection. This additional acceleration is due to the filamentation of electric and magnetic fields caused by streaming instabilities. In addition to enhanced parallel electric fields, the filamentation leads to additional curvature-driven electron acceleration in the guide-field direction. As a result, part of the the accelerated electron spectra becomes a power law with a spectral index of $\sim-1.6$ near the X-line. This second stage of acceleration due to nonlinear reconnection is relevant for the production of energetic electrons in, e.g., thin current sheets of stellar coronae., Comment: 15 pages. 11 figures. Revised version. Published in The Astrophysical Journal

Although turbulence has been conjectured to be important for magnetic reconnection, still very little is known about its role in collisionless plasmas. Previous attempts to quantify the effect of turbulence on reconnection usually prescribed Alfv\'enic or other low-frequency fluctuations or investigated collisionless kinetic effects in just two-dimensional configurations and antiparallel magnetic fields. In view of this, we analyzed the kinetic turbulence self-generated by three-dimensional guide-field reconnection through force-free current sheets in frequency and wavenumber spaces, utilizing 3D particle-in-cell code numerical simulations. Our investigations reveal reconnection rates and kinetic turbulence with features similar to those obtained by current in-situ spacecraft observations of MMS as well as in the laboratory reconnection experiments MRX, VTF and \textsc{Vineta}-II. In particular we found that the kinetic turbulence developing in the course of 3D guide-field reconnection exhibits a broadband power-law spectrum extending beyond the lower-hybrid frequency and up to the electron frequencies. In the frequency space the spectral index of the turbulence appeared to be close to -2.8 at the reconnection X-line. In the wavenumber space it also becomes -2.8 as soon as the normalized reconnection rate reaches 0.1. The broadband kinetic turbulence is mainly due to current-streaming and electron-flow-shear instabilities excited in the sufficiently thin current sheets of kinetic reconnection. The growth of the kinetic turbulence corresponds to high reconnection rates which exceed those of fast laminar, non-turbulent reconnection., Comment: 13 pages, 10 figures. Revised version. Published in Physical Review E

Aims: We investigate the electron acceleration in convective electric fields of cascading magnetic reconnection in a flaring solar corona and show the resulting hard X-ray (HXR) radiation spectra caused by Bremsstrahlung for the coronal source. Methods: We perform test particle calculation of electron motions in the framework of a guiding center approximation. The electromagnetic fields and their derivatives along electron trajectories are obtained by linearly interpolating the results of high-resolution adaptive mesh refinement (AMR) MHD simulations of cascading magnetic reconnection. Hard X-ray (HXR) spectra are calculated using an optically thin Bremsstrahlung model. Results: Magnetic gradients and curvatures in cascading reconnection current sheet accelerate electrons: trapped in magnetic islands, precipitating to the chromosphere and ejected into the interplanetary space. The final location of an electron is determined by its initial position, pitch angle and velocity. These initial conditions also influence electron acceleration efficiency. Most of electrons have enhanced perpendicular energy. Trapped electrons are considered to cause the observed bright spots along coronal mass ejection CME-trailing current sheets as well as the flare loop-top HXR emissions., Comment: submitted to A&A

The Lausitz (Lusatia) Volcanic Field is part of the Central European Volcanic Province, and its magmas represent an alkaline trend from olivine nephelinites and basanites to trachytes and phonolites, typical for intraplate settings. Neighbouring volcanic fields are the České Strˇedohorˇí Mountains to the south-west and the Fore-Sudetic Basin in Lower Silesia to the east. More than 1000 volcanic structures associated with approximately 500 vents have been located within this volcanic field. Residuals of scoria cones, lava lakes, lava flows and maardiatreme in filling occur in situ near the level of the original syn-volcanic terrain. In more deeply eroded structures, volcanic relicts outcrop as plugs or feeders. Evolved rocks occur as monogenetic domes or intrusions in diatremes, while their volcaniclastic equivalents are rare. Twenty-three localities were dated using the 40Ar/39Ar method. The ages range from 35 to 27 Ma, with a focus around 32–29 Ma, indicating Late Eocene and mainly Oligocene volcanism for the LVF. Differentiated rocks appear to be slightly younger than less differentiated. No geographical age clusters are apparent.

Aims: We investigate the electron acceleration in convective electric fields of cascading magnetic reconnection in a flaring solar corona and show the resulting hard X-ray (HXR) radiation spectra caused by Bremsstrahlung for the coronal source. Methods: We perform test particle calculation of electron motions in the framework of a guiding center approximation. The electromagnetic fields and their derivatives along electron trajectories are obtained by linearly interpolating the results of high-resolution adaptive mesh refinement (AMR) MHD simulations of cascading magnetic reconnection. Hard X-ray (HXR) spectra are calculated using an optically thin Bremsstrahlung model. Results: Magnetic gradients and curvatures in cascading reconnection current sheet accelerate electrons: trapped in magnetic islands, precipitating to the chromosphere and ejected into the interplanetary space. The final location of an electron is determined by its initial position, pitch angle and velocity. These initial conditions also influence electron acceleration efficiency. Most of electrons have enhanced perpendicular energy. Trapped electrons are considered to cause the observed bright spots along coronal mass ejection CME-trailing current sheets as well as the flare loop-top HXR emissions., Comment: submitted to A&A

The Lausitz (Lusatia) Volcanic Field is part of the Central European Volcanic Province, and its magmas represent an alkaline trend from olivine nephelinites and basanites to trachytes and phonolites, typical for intraplate settings. Neighbouring volcanic fields are the České Strˇedohorˇí Mountains to the south-west and the Fore-Sudetic Basin in Lower Silesia to the east. More than 1000 volcanic structures associated with approximately 500 vents have been located within this volcanic field. Residuals of scoria cones, lava lakes, lava flows and maardiatreme in filling occur in situ near the level of the original syn-volcanic terrain. In more deeply eroded structures, volcanic relicts outcrop as plugs or feeders. Evolved rocks occur as monogenetic domes or intrusions in diatremes, while their volcaniclastic equivalents are rare. Twenty-three localities were dated using the 40Ar/39Ar method. The ages range from 35 to 27 Ma, with a focus around 32–29 Ma, indicating Late Eocene and mainly Oligocene volcanism for the LVF. Differentiated rocks appear to be slightly younger than less differentiated. No geographical age clusters are apparent.

The numerical simulation of turbulence and flows in almost ideal, large-Reynolds-number astrophysical plasmas motivates the implementation of almost conservative MHD computer codes. They should efficiently calculate, use highly parallelized schemes scaling well with large numbers of CPU cores, allows to obtain a high grid resolution over large simulation domains and which can easily be adapted to new computer architectures as well as to new initial and boundary conditions, allow modular extensions. The new massively parallel simulation code GOEMHD3 enables efficient and fast simulations of almost ideal, large-Reynolds-number astrophysical plasma flows, well resolved and on huge grids covering large domains. Its abilities are validated by major tests of ideal and weakly dissipative plasma phenomena. The high resolution ($2048^3$ grid points) simulation of a large part of the solar corona above an observed active region proved the excellent parallel scalability of the code using more than 30.000 processor cores., Comment: The revised version

The numerical simulation of turbulence and flows in almost ideal, large-Reynolds-number astrophysical plasmas motivates the implementation of almost conservative MHD computer codes. They should efficiently calculate, use highly parallelized schemes scaling well with large numbers of CPU cores, allows to obtain a high grid resolution over large simulation domains and which can easily be adapted to new computer architectures as well as to new initial and boundary conditions, allow modular extensions. The new massively parallel simulation code GOEMHD3 enables efficient and fast simulations of almost ideal, large-Reynolds-number astrophysical plasma flows, well resolved and on huge grids covering large domains. Its abilities are validated by major tests of ideal and weakly dissipative plasma phenomena. The high resolution ($2048^3$ grid points) simulation of a large part of the solar corona above an observed active region proved the excellent parallel scalability of the code using more than 30.000 processor cores., Comment: The revised version

We present a newly developed approach to solar coronal magnetic field extrapolation from vector magnetograms, based on the Principle of Minimum Dissipation Rate (MDR). The MDR system was derived from a variational problem that is more suitable for an open and externally driven system, like the solar corona. The resulting magnetic field equation is more general than force-free. Its solution can be expressed as the superposition of two linear (constant-$\alpha$) force-free fields (LFFFs) with distinct $\alpha$ parameters, and one potential field. Thus the original extrapolation problem is decomposed into three LFFF extrapolations, utilizing boundary data. The full MDR-based approach requires two layers of vector magnetograph measurements on solar surface, while a slightly modified practical approach only requires one. We test both approaches against 3D MHD simulation data in a finite volume. Both yield quantitatively good results. The errors in the magnetic energy estimate are within a few percents. In particular, the main features of relatively strong perpendicular current density structures, representative of the non-force freeness of the solution, are well recovered., Comment: submitted to ApJ

We present a newly developed approach to solar coronal magnetic field extrapolation from vector magnetograms, based on the Principle of Minimum Dissipation Rate (MDR). The MDR system was derived from a variational problem that is more suitable for an open and externally driven system, like the solar corona. The resulting magnetic field equation is more general than force-free. Its solution can be expressed as the superposition of two linear (constant-$\alpha$) force-free fields (LFFFs) with distinct $\alpha$ parameters, and one potential field. Thus the original extrapolation problem is decomposed into three LFFF extrapolations, utilizing boundary data. The full MDR-based approach requires two layers of vector magnetograph measurements on solar surface, while a slightly modified practical approach only requires one. We test both approaches against 3D MHD simulation data in a finite volume. Both yield quantitatively good results. The errors in the magnetic energy estimate are within a few percents. In particular, the main features of relatively strong perpendicular current density structures, representative of the non-force freeness of the solution, are well recovered., Comment: submitted to ApJ

We present a newly developed approach to solar coronal magnetic field extrapolation from vector magnetograms, based on the Principle of Minimum Dissipation Rate (MDR). The MDR system was derived from a variational problem that is more suitable for an open and externally driven system, like the solar corona. The resulting magnetic field equation is more general than force-free. Its solution can be expressed as the superposition of two linear (constant-$\alpha$) force-free fields (LFFFs) with distinct $\alpha$ parameters, and one potential field. Thus the original extrapolation problem is decomposed into three LFFF extrapolations, utilizing boundary data. The full MDR-based approach requires two layers of vector magnetograph measurements on solar surface, while a slightly modified practical approach only requires one. We test both approaches against 3D MHD simulation data in a finite volume. Both yield quantitatively good results. The errors in the magnetic energy estimate are within a few percents. In particular, the main features of relatively strong perpendicular current density structures, representative of the non-force freeness of the solution, are well recovered., Comment: submitted to ApJ

von J. L. Büchner

International audience, The advanced energetic particle spectrometer RAPID on board Cluster can provide a complete description of the relevant particle parameters velocity, V , and atomic mass, A, over an energy range from 30 keV up to 1.5 MeV. We present the first measurements taken by RAPID during the commissioning and the early operating phases. The orbit on 14 January 2001, when Cluster was travelling from a perigee near dawn northward across the pole towards an apogee in the solar wind, is used to demonstrate the capabilities of RAPID in investigating a wide variety of particle populations. RAPID, with its unique capability of measuring the complete angular distribution of energetic particles, allows for the simultaneous measurements of local density gradients, as reflected in the anisotropies of 90° particles and the remote sensing of changes in the distant field line topology, as manifested in the variations of loss cone properties. A detailed discussion of angle-angle plots shows considerable differences in the structure of the boundaries between the open and closed field lines on the nightside fraction of the pass and the magnetopause crossing. The 3 March 2001 encounter of Cluster with an FTE just outside the magnetosphere is used to show the first structural plasma investigations of an FTE by energetic multi-spacecraft observations.