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24 results on '"Atrial cardiomyopathy"'

1. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus
Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract
Published: 2024
Full Text: View/download PDF

2. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus
Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract
Published: 2024
Full Text: View/download PDF

3. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus
Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract
Published: 2024
Full Text: View/download PDF

4. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus
Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract
Published: 2024
Full Text: View/download PDF

5. Longer and better lives for patients with atrial fibrillation:the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchho, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchho, Paulus
Abstract: Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) Methods Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm and results management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF.Conclusions Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.
Published: 2024

6. Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation

Author: Vad, Oliver B., Angeli, Elisavet, Liss, Martin, Ahlberg, Gustav, Andreasen, Laura, Christophersen, Ingrid E., Hansen, Camilla C., Møller, Sophie, Hellsten, Ylva, Haunsoe, Stig, Tveit, Arnljot, Svendsen, Jesper H., Gotthardt, Michael, Lundegaard, Pia R., Olesen, Morten S., Vad, Oliver B., Angeli, Elisavet, Liss, Martin, Ahlberg, Gustav, Andreasen, Laura, Christophersen, Ingrid E., Hansen, Camilla C., Møller, Sophie, Hellsten, Ylva, Haunsoe, Stig, Tveit, Arnljot, Svendsen, Jesper H., Gotthardt, Michael, Lundegaard, Pia R., and Olesen, Morten S.
Abstract: We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of RBM20, we demonstrated altered splicing of sarcomere genes (NEXN, TTN, TPM1, MYOM1, and LDB3), and differential expression in key cardiac genes. We identified altered sarcomere and mitochondrial structure on electron microscopy imaging and found compromised mitochondrial function. Finally, we demonstrated that 3 novel LOF variants in RBM20, identified in patients with atrial fibrillation, lead to significantly reduced splicing activity. Our results implicate alternative splicing as a novel proarrhythmic mechanism in the atria.
Published: 2024

7. Longer and better lives for patients with atrial fibrillation:the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchho, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stéphane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, José Luis, Metzner, Andreas, Mont, Lluís, Andre Ng, Ghulam, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchho, Paulus
Abstract: Aims Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) Methods Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm and results management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF.Conclusions Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.
Published: 2024

8. Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation

Author: Vad, Oliver B., Angeli, Elisavet, Liss, Martin, Ahlberg, Gustav, Andreasen, Laura, Christophersen, Ingrid E., Hansen, Camilla C., Møller, Sophie, Hellsten, Ylva, Haunsoe, Stig, Tveit, Arnljot, Svendsen, Jesper H., Gotthardt, Michael, Lundegaard, Pia R., Olesen, Morten S., Vad, Oliver B., Angeli, Elisavet, Liss, Martin, Ahlberg, Gustav, Andreasen, Laura, Christophersen, Ingrid E., Hansen, Camilla C., Møller, Sophie, Hellsten, Ylva, Haunsoe, Stig, Tveit, Arnljot, Svendsen, Jesper H., Gotthardt, Michael, Lundegaard, Pia R., and Olesen, Morten S.
Abstract: We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of RBM20, we demonstrated altered splicing of sarcomere genes (NEXN, TTN, TPM1, MYOM1, and LDB3), and differential expression in key cardiac genes. We identified altered sarcomere and mitochondrial structure on electron microscopy imaging and found compromised mitochondrial function. Finally, we demonstrated that 3 novel LOF variants in RBM20, identified in patients with atrial fibrillation, lead to significantly reduced splicing activity. Our results implicate alternative splicing as a novel proarrhythmic mechanism in the atria.
Published: 2024

9. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

Author: Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, Kirchhof, Paulus, Linz, Dominik, Andrade, Jason G., Arbelo, Elena, Boriani, Giuseppe, Breithardt, Guenter, Camm, A. John, Caso, Valeria, Nielsen, Jens Cosedis, De Melis, Mirko, De Potter, Tom, Dichtl, Wolfgang, Diederichsen, Søren Zoega, Dobrev, Dobromir, Doll, Nicolas, Duncker, David, Dworatzek, Elke, Eckardt, Lars, Eisert, Christoph, Fabritz, Larissa, Farkowski, Michal, Filgueiras-Rama, David, Goette, Andreas, Guasch, Eduard, Hack, Guido, Hatem, Stephane, Haeusler, Karl Georg, Healey, Jeff S., Heidbuechel, Hein, Hijazi, Ziad, Hofmeister, Lucas H., Hove-Madsen, Leif, Huebner, Thomas, Kääb, Stefan, Kotecha, Dipak, Malaczynska-Rajpold, Katarzyna, Merino, Jose Luis, Metzner, Andreas, Mont, Lluis, Ng, Ghulam Andre, Oeff, Michael, Parwani, Abdul Shokor, Puererfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Sanders, Prashanthan, Scherr, Daniel, Schnabel, Renate, Schotten, Ulrich, Sohns, Christian, Steinbeck, Gerhard, Steven, Daniel, Toennis, Tobias, Tzeis, Stylianos, van Gelder, Isabelle C., van Leerdam, Roderick H., Vernooy, Kevin, Wadhwa, Manish, Wakili, Reza, Willems, Stephan, Witt, Henning, Zeemering, Stef, and Kirchhof, Paulus
Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Munster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Graphical Abstract
Published: 2024
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10. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
Abstract: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023
Full Text: View/download PDF

11. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
Abstract: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023
Full Text: View/download PDF

12. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
Abstract: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023
Full Text: View/download PDF

13. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
Abstract: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023
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14. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
Abstract: Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023
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15. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, Kirchhof, Paulus, Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, and Kirchhof, Paulus
Abstract: Aims Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. Methods and results This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Conclusions Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023

16. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference

Author: Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, Kirchhof, Paulus, Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, and Kirchhof, Paulus
Abstract: Aims Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. Methods and results This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Conclusions Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
Published: 2023

17. Left atrial late gadolinium enhancement in patients with ischaemic stroke

Author: Larsen, Bjørn Strøier, Bertelsen, Litten, Christensen, Hanne, Hadad, Rakin, Aplin, Mark, Høst, Nis, Christensen, Louisa Marguerite, Havsteen, Inger, Prescott, Eva, Dominguez, Helena, Jensen, Gorm Boje, Vejlstrup, Niels, Sajadieh, Ahmad, Larsen, Bjørn Strøier, Bertelsen, Litten, Christensen, Hanne, Hadad, Rakin, Aplin, Mark, Høst, Nis, Christensen, Louisa Marguerite, Havsteen, Inger, Prescott, Eva, Dominguez, Helena, Jensen, Gorm Boje, Vejlstrup, Niels, and Sajadieh, Ahmad
Abstract: Aims To evaluate the extent of left atrial (LA) fibrosis in patients with a recent stroke without atrial fibrillation and controls without established cardiovascular disease. Methods and results This prospectively designed study used cardiac magnetic resonance to detect LA late gadolinium enhancement as a proxy for LA fibrosis. Between 2019 and 2021, we consecutively included 100 patients free of atrial fibrillation with recent ischaemic stroke (<30 days) and 50 age- and sex-matched controls. LA fibrosis assessment was achieved in 78 patients and 45 controls. Blinded to the cardiac magnetic resonance results, strokes were adjudicated according to modified Trial of Org 10172 in Acute Stroke Treatment classification as undetermined aetiology (n = 42) or as attributable to large- or small-vessel disease (n = 36). Patients with stroke had a larger extent of LA fibrosis [6.9%, interquartile range (IQR) 3.6–15.4%] than matched controls (4.2%, IQR 2.3–7.5%; P = 0.007). No differences in LA fibrosis were observed between patients with stroke of undetermined aetiology and those with large- or small-vessel disease (6.6%, IQR 3.8–16.0% vs. 6.9%, IQR 3.4–14.6%; P = 0.73). Conclusion LA fibrosis was more extensive in patients with stroke than in age- and sex-matched controls. A similar extent of LA fibrosis was observed in patients with stroke of undetermined aetiology and stroke classified as attributable to large- or small-vessel disease. Our findings suggest that LA structural abnormality is more frequent in patients with stroke than in controls independent of aetiological classification., Aims To evaluate the extent of left atrial (LA) fibrosis in patients with a recent stroke without atrial fibrillation and controls without established cardiovascular disease. Methods This prospectively designed study used cardiac magnetic resonance to detect LA late gadolinium enhancement as a proxy for and results LA fibrosis. Between 2019 and 2021, we consecutively included 100 patients free of atrial fibrillation with recent ischaemic stroke (<30 days) and 50 age- and sex-matched controls. LA fibrosis assessment was achieved in 78 patients and 45 controls. Blinded to the cardiac magnetic resonance results, strokes were adjudicated according to modified Trial of Org 10172 in Acute Stroke Treatment classification as undetermined aetiology (n = 42) or as attributable to large- or small-vessel disease (n = 36). Patients with stroke had a larger extent of LA fibrosis [6.9%, interquartile range (IQR) 3.6–15.4%] than matched controls (4.2%, IQR 2.3–7.5%; P = 0.007). No differences in LA fibrosis were observed between patients with stroke of undetermined aetiology and those with large- or small-vessel disease (6.6%, IQR 3.8–16.0% vs. 6.9%, IQR 3.4–14.6%; P = 0.73). Conclusion LA fibrosis was more extensive in patients with stroke than in age- and sex-matched controls. A similar extent of LA fibrosis was observed in patients with stroke of undetermined aetiology and stroke classified as attributable to large- or small-vessel disease. Our findings suggest that LA structural abnormality is more frequent in patients with stroke than in controls independent of aetiological classification.
Published: 2023

18. Echocardiography and Electrocardiography in Detecting Atrial Cardiomyopathy: A Promising Path to Predicting Cardioembolic Strokes and Atrial Fibrillation

Author: Medicina i Cirurgia, Universitat Rovira i Virgili, Gentille-Lorente, D; Hernández-Pinilla, A; Satue-Gracia, E; Muria-Subirats, E; Forcadell-Peris, MJ; Gentille-Lorente, J; Ballesta-Ors, J; Martín-Lujan, FM; Clua-Espuny, JL, Medicina i Cirurgia, Universitat Rovira i Virgili, and Gentille-Lorente, D; Hernández-Pinilla, A; Satue-Gracia, E; Muria-Subirats, E; Forcadell-Peris, MJ; Gentille-Lorente, J; Ballesta-Ors, J; Martín-Lujan, FM; Clua-Espuny, JL
Abstract: (1) Background: Atrial cardiomyopathy constitutes an intrinsically prothrombotic atrial substrate that may promote atrial fibrillation and thromboembolic events, especially stroke, independently of the arrhythmia. Atrial reservoir strain is the echocardiography marker with the most robust evidence supporting its prognostic utility. The main aim of this study is to identify atrial cardiomyopathy by investigating the association between left atrial dysfunction in echocardiography and P-wave abnormalities in the surface electrocardiogram. (2) Methods: This is a community-based, multicenter, prospective cohort study. A randomized sample of 100 patients at a high risk of developing atrial fibrillation were evaluated using diverse echocardiography imaging techniques, and a standard electrocardiogram. (3) Results: Significant left atrial dysfunction, expressed by a left atrial reservoir strain < 26%, showed a relationship with the dilation of the left atrium (p < 0.001), the left atrial ejection fraction < 50% (p < 0.001), the presence of advanced interatrial block (p = 0.032), P-wave voltage in lead I < 0.1 mV (p = 0.008), and MVP ECG score (p = 0.036). (4) Conclusions: A significant relationship was observed between left atrial dysfunction and the presence of left atrial enlargement and other electrocardiography markers; all of them are non-invasive biomarkers of atrial cardiomyopathy.
Published: 2023

19. Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

Author: Palà, Elena, Pagola, Jorge, Juega, Jesus, Francisco Pascual, Jaume, Penalba, Anna, Rodriguez, Maite, De Lera Alfonso, Mercedes, Arenillas, Juan F., Cabezas, Juan Antonio, Moniche, Francisco, de Torres, Reyes, Pérez-Sánchez, Soledad, González-Alujas, Teresa, Molina, Carlos A., Bustamante, Alejandro, Montaner, Joan, Universitat Autònoma de Barcelona, Palà, Elena, Pagola, Jorge, Juega, Jesus, Francisco Pascual, Jaume, Penalba, Anna, Rodriguez, Maite, De Lera Alfonso, Mercedes, Arenillas, Juan F., Cabezas, Juan Antonio, Moniche, Francisco, de Torres, Reyes, Pérez-Sánchez, Soledad, González-Alujas, Teresa, Molina, Carlos A., Bustamante, Alejandro, Montaner, Joan, and Universitat Autònoma de Barcelona
Abstract: Atrial fibrillation (AF) is one of the most prevalent causes of cryptogenic stroke. Also, apart from AF itself, structural and remodelling changes in the atria might be an underlying cause of cryptogenic stroke. We aimed to discover circulating proteins and reveal pathways altered in AF and atrial cardiomyopathy, measured by left atrial volume index (LAVI) and peak atrial longitudinal strain (PALS), in patients with cryptogenic stroke. An aptamer array (including 1310 proteins) was measured in the blood of 20 cryptogenic stroke patients monitored during 28 days with a Holter device as a case-control study of the Crypto-AF cohort. Protein levels were compared between patients with (n = 10) and without AF (n = 10) after stroke, and the best candidates were tested in 111 patients from the same cohort (44 patients with AF and 67 without AF). In addition, in the first 20 patients, proteins were explored according to PALS and LAVI values. Forty-six proteins were differentially expressed in AF cases. Of those, four proteins were tested in a larger sample size. Only DPP7, presenting lower levels in AF patients, was further validated. Fifty-seven proteins correlated with LAVI, and 270 correlated with PALS. NT-proBNP was common in all the discovery analyses performed. Interestingly, many proteins and pathways were altered in patients with low PALS. Multiple proteins and pathways related to AF and atrial cardiomyopathy have been revealed. The role of DPP7 as a biomarker for stroke aetiology should be further explored. Moreover, the present study may be considered hypothesis-generating
Published: 2022

20. Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

Author: Instituto de Salud Carlos III, European Commission, Vall d'Hebron Research Institute, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Palà, Elena, Pagola, Jorge, Juega, Jesus, Francisco-Pascual, Jaume, Penalba, Anna, Rodíiguez, Maite A., Lera Alfonso, Mercedes de, Arenillas, Juan F., Cabezas, Juan A., Moniche, Francisco, Torres, Reyes de, Pérez-Sánchez, Soledad, González-Alujas, Teresa, Molina, Carlos A., Bustamante, Alejandro, Montaner, Joan, Instituto de Salud Carlos III, European Commission, Vall d'Hebron Research Institute, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Palà, Elena, Pagola, Jorge, Juega, Jesus, Francisco-Pascual, Jaume, Penalba, Anna, Rodíiguez, Maite A., Lera Alfonso, Mercedes de, Arenillas, Juan F., Cabezas, Juan A., Moniche, Francisco, Torres, Reyes de, Pérez-Sánchez, Soledad, González-Alujas, Teresa, Molina, Carlos A., Bustamante, Alejandro, and Montaner, Joan
Abstract: [Background] Atrial fibrillation (AF) is one of the most prevalent causes of cryptogenic stroke. Also, apart from AF itself, structural and remodelling changes in the atria might be an underlying cause of cryptogenic stroke. We aimed to discover circulating proteins and reveal pathways altered in AF and atrial cardiomyopathy, measured by left atrial volume index (LAVI) and peak atrial longitudinal strain (PALS), in patients with cryptogenic stroke., [Methods] An aptamer array (including 1310 proteins) was measured in the blood of 20 cryptogenic stroke patients monitored during 28 days with a Holter device as a case-control study of the Crypto-AF cohort. Protein levels were compared between patients with (n = 10) and without AF (n = 10) after stroke, and the best candidates were tested in 111 patients from the same cohort (44 patients with AF and 67 without AF). In addition, in the first 20 patients, proteins were explored according to PALS and LAVI values., [Results] Forty-six proteins were differentially expressed in AF cases. Of those, four proteins were tested in a larger sample size. Only DPP7, presenting lower levels in AF patients, was further validated. Fifty-seven proteins correlated with LAVI, and 270 correlated with PALS. NT-proBNP was common in all the discovery analyses performed. Interestingly, many proteins and pathways were altered in patients with low PALS., [Conclusions] Multiple proteins and pathways related to AF and atrial cardiomyopathy have been revealed. The role of DPP7 as a biomarker for stroke aetiology should be further explored. Moreover, the present study may be considered hypothesis-generating.
Published: 2022

21. Neue Konzepte der Pathophysiologie von Vorhofflimmern

Author: Hermans, Ben J.M., Weberndörfer, Vanessa, Bijvoet, Geertruida P., Chaldoupi, Sevasti Maria, Linz, Dominik, Hermans, Ben J.M., Weberndörfer, Vanessa, Bijvoet, Geertruida P., Chaldoupi, Sevasti Maria, and Linz, Dominik
Abstract: The current classification of atrial fibrillation (AF) is mainly focused on the clinical presentation according to the duration of AF episodes and the mode of termination, which incompletely reflect the severity and progressive nature of the underlying atrial disease. In this review article, “atrial cardiomyopathy” is discussed as a new concept in AF pathophysiology. Electrogram-, imaging-, and biomarker-derived measures and parameters to assess atrial cardiomyopathy, which will likely impact how AF is clinically classified and managed in the future, are presented.
Published: 2022

22. Left Atrial Remodeling and Cerebrovascular Disease Assessed by Magnetic Resonance Imaging in Continuously Monitored Patients

Author: Bertelsen, Litten, Diederichsen, Søren Zöga, Frederiksen, Kristian Steen, Haugan, Ketil Jørgen, Brandes, Axel, Graff, Claus, Krieger, Derk, Højberg, Søren, Olesen, Morten S., Biering-Sørensen, Tor, Køber, Lars, Vejlstrup, Niels, Hasselbalch, Steen Gregers, Svendsen, Jesper Hastrup, Bertelsen, Litten, Diederichsen, Søren Zöga, Frederiksen, Kristian Steen, Haugan, Ketil Jørgen, Brandes, Axel, Graff, Claus, Krieger, Derk, Højberg, Søren, Olesen, Morten S., Biering-Sørensen, Tor, Køber, Lars, Vejlstrup, Niels, Hasselbalch, Steen Gregers, and Svendsen, Jesper Hastrup
Abstract: Background: Atrial remodeling is associated with future atrial fibrillation (AF) and stroke. AF has been associated with cognitive impairment and cerebral white matter lesions. We wished to investigate the possible direct association between atrial remodeling and cerebrovascular disease in patients with and without AF documented by implantable loop recorder (ILR). Methods: Cardiac and cerebral magnetic resonance imaging were acquired in a cross-sectional study, including participants ≥70 years of age with stroke risk factors without known AF. Cerebrovascular disease was visually rated using the Fazekas scale and number of lacunar strokes. Left atrial (LA) and ventricular volumes and function were analyzed. Associations between atrial remodeling and cerebrovascular disease were assessed with logistic regression models. The analyses were stratified according to sinus rhythm or any AF during 3 months of continuous ILR monitoring to account for subclinical AF. Results: Of 200 participants investigated, 87% had a Fazekas score ≥1 and 45% had ≥1 lacunar infarct. Within 3 months of ILR monitoring, AF was detected in 28 (14%) participants. For participants with sinus rhythm (n = 172), lower LA passive emptying fraction was associated with Fazekas score after multivariable adjustment (OR [95% CI]: 0.51 [0.27; 0.86] p = 0.02), and increased LA maximum (OR [95% CI]: 1.38 [1.07; 1.82] p = 0.01) and minimum volumes (OR [95% CI]: 1.48 [1.03; 2.17] p = 0.04) were associated with lacunar infarcts. There were no significant associations in patients with AF. Conclusion: In AF-free patients, as documented by ILR monitoring, we found an independent association between LA passive emptying fraction and Fazekas score and between atrial volumes and lacunar infarcts.
Published: 2022

23. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation : the 7th AFNET/EHRA Consensus Conference

Author: Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, Kirchhof, Paulus, Fabritz, Larissa, Crijns, Harry J. G. M., Guasch, Eduard, Goette, Andreas, Häusler, Karl Georg, Kotecha, Dipak, Lewalter, Thorsten, Meyer, Christian, Potpara, Tatjana S., Rienstra, Michiel, Schnabel, Renate B., Willems, Stephan, Breithardt, Guenter, Camm, A. John, Chan, Anthony, Chua, Winnie, de Melis, Mirko, Dimopoulou, Christina, Dobrev, Dobromir, Easter, Christina, Eckardt, Lars, Haase, Doreen, Hatem, Stephane, Healey, Jeff S., Heijman, Jordi, Hohnloser, Stefan H., Huebner, Thomas, Ilyas, Bushra Saeed, Isaacs, Aaron, Kutschka, Ingo, Leclercq, Christophe, Lip, Gregory Y. H., Marinelli, Elena Andreassi, Merino, Jose L., Mont, Lluís, Nabauer, Michael, Oldgren, Jonas, Pürerfellner, Helmut, Ravens, Ursula, Savelieva, Irina, Sinner, Moritz F., Sitch, Alice, Smolnik, Rüdiger, Steffel, Jan, Stein, Kenneth, Stoll, Monika, Svennberg, Emma, Thomas, Dierk, Van Gelder, Isabelle C., Vardar, Burcu, Wakili, Reza, Wieloch, Mattias, Zeemering, Stef, Ziegler, Paul D., Heidbuchel, Hein, Hindricks, Gerhard, Schotten, Ulrich, and Kirchhof, Paulus
Abstract: Aims The risk of developing atrial fibrillation (AF) and its complications continues to increase, despite good progress in preventing AF-related strokes. Methods and results This article summarizes the outcomes of the 7th Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA) held in Lisbon in March 2019. Sixty-five international AF specialists met to present new data and find consensus on pressing issues in AF prevention, management and future research to improve care for patients with AF and prevent AF-related complications. This article is the main outcome of an interactive, iterative discussion between breakout specialist groups and the meeting plenary. AF patients have dynamic risk profiles requiring repeated assessment and risk-based therapy stratification to optimize quality of care. Interrogation of deeply phenotyped datasets with outcomes will lead to a better understanding of the cardiac and systemic effects of AF, interacting with comorbidities and predisposing factors, enabling stratified therapy. New proposals include an algorithm for the acute management of patients with AF and heart failure, a call for a refined, data-driven assessment of stroke risk, suggestions for anticoagulation use in special populations, and a call for rhythm control therapy selection based on risk of AF recurrence. Conclusion The remaining morbidity and mortality in patients with AF needs better characterization. Likely drivers of the remaining AF-related problems are AF burden, potentially treatable by rhythm control therapy, and concomitant conditions, potentially treatable by treating these conditions. Identifying the drivers of AF-related complications holds promise for stratified therapy.
Published: 2021
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24. DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?

Author: Ramos, K.S., Brundel, B., Ramos, K.S., and Brundel, B.
Abstract: Atrial Fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to progress in time. AF is difficult to treat and therefore there is a great need to dissect root causes of AF with the ultimate goal to develop mechanism-based (drug) therapies. New findings related to mechanisms driving AF progression indicate a prime role for DNA damage-induced metabolic remodeling. A recent study uncovered that AF results in oxidative DNA damage and consequently excessive poly-ADP-ribose polymerase 1 (PARP1) activation and nicotinamide adenine dinucleotide (NAD+) depletion and finally atrial cardiomyocyte electrical and contractile dysfunction. This newly elucidated role of DNA damage in AF opens opportunities for novel therapeutic strategies. Recently developed PARP inhibitors, such as ABT-888 and olaparib, provide beneficial effects in limiting experimental AF, and are also found to limit atherosclerotic coronary artery disease and heart failure. Another therapeutic option to protect against AF is to replenish the NAD+ pool by supplementation with NAD+ or its precursors, such as nicotinamide and nicotinamide riboside. In this review, we describe the role of DNA damage-mediated metabolic remodeling in AF and other cardiovascular diseases, discuss novel druggable targets for AF and highlight future directions for clinical trials with drugs directed at PARP1-NAD+ pathway with the ultimate aim to preserve quality of life and to attenuate severe complications such as heart failure or stroke in patients with AF
Published: 2020
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24 results on '"Atrial cardiomyopathy"'

1. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

2. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

3. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

4. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

5. Longer and better lives for patients with atrial fibrillation:the 9th AFNET/EHRA consensus conference

6. Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation

7. Longer and better lives for patients with atrial fibrillation:the 9th AFNET/EHRA consensus conference

8. Loss of Cardiac Splicing Regulator RBM20 Is Associated With Early-Onset Atrial Fibrillation

9. Longer and better lives for patients with atrial fibrillation : the 9th AFNET/EHRA consensus conference

10. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

11. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

12. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

13. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

14. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference

15. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference

16. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference

17. Left atrial late gadolinium enhancement in patients with ischaemic stroke

18. Echocardiography and Electrocardiography in Detecting Atrial Cardiomyopathy: A Promising Path to Predicting Cardioembolic Strokes and Atrial Fibrillation

19. Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

20. Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

21. Neue Konzepte der Pathophysiologie von Vorhofflimmern

22. Left Atrial Remodeling and Cerebrovascular Disease Assessed by Magnetic Resonance Imaging in Continuously Monitored Patients

23. Dynamic risk assessment to improve quality of care in patients with atrial fibrillation : the 7th AFNET/EHRA Consensus Conference

24. DNA Damage, an Innocent Bystander in Atrial Fibrillation and Other Cardiovascular Diseases?

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