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4 results on '"Asinovski, N"'

1. Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Author

Massachusetts Institute of Technology. Department of Biology, Regev, Aviv, Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., Feng, T., Lee, M., Asinovski, N., Frohlich, I., Imboywa, S., Von Korff, A., Okada, Y., Patsopoulos, N. A., Davis, S., McCabe, C., Paik, H.-i., Srivastava, G. P., Raychaudhuri, S., Hafler, D. A., Koller, D., Hacohen, N., Mathis, D., Benoist, C., Stranger, B. E., De Jager, P. L., Massachusetts Institute of Technology. Department of Biology, Regev, Aviv, Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., Feng, T., Lee, M., Asinovski, N., Frohlich, I., Imboywa, S., Von Korff, A., Okada, Y., Patsopoulos, N. A., Davis, S., McCabe, C., Paik, H.-i., Srivastava, G. P., Raychaudhuri, S., Hafler, D. A., Koller, D., Hacohen, N., Mathis, D., Benoist, C., Stranger, B. E., and De Jager, P. L.

Abstract

To extend our understanding of the genetic basis of human immune function and dysfunction, we performed an expression quantitative trait locus (eQTL) study of purified CD4[superscript +] T cells and monocytes, representing adaptive and innate immunity, in a multi-ethnic cohort of 461 healthy individuals. Context-specific cis- and trans-eQTLs were identified, and cross-population mapping allowed, in some cases, putative functional assignment of candidate causal regulatory variants for disease-associated loci. We note an over-representation of T cell–specific eQTLs among susceptibility alleles for autoimmune diseases and of monocyte-specific eQTLs among Alzheimer’s and Parkinson’s disease variants. This polarization implicates specific immune cell types in these diseases and points to the need to identify the cell-autonomous effects of disease susceptibility variants.

Published
2017

2. Intersection of population variation and autoimmunity genetics in human T cell activation

Author

Massachusetts Institute of Technology. Department of Biology, Regev, Aviv, Ye, C. J., Feng, T., Kwon, H.-K., Raj, T., Wilson, M. T., Asinovski, N., McCabe, C., Lee, M. H., Frohlich, I., Paik, H.-i., Zaitlen, N., Hacohen, N., Stranger, B., De Jager, P., Mathis, D., Benoist, C., Massachusetts Institute of Technology. Department of Biology, Regev, Aviv, Ye, C. J., Feng, T., Kwon, H.-K., Raj, T., Wilson, M. T., Asinovski, N., McCabe, C., Lee, M. H., Frohlich, I., Paik, H.-i., Zaitlen, N., Hacohen, N., Stranger, B., De Jager, P., Mathis, D., and Benoist, C.

Abstract

T lymphocyte activation by antigen conditions adaptive immune responses and immunopathologies, but we know little about its variation in humans and its genetic or environmental roots. We analyzed gene expression in CD4[superscript +] T cells during unbiased activation or in T helper 17 (T[subscript H]17) conditions from 348 healthy participants representing European, Asian, and African ancestries. We observed interindividual variability, most marked for cytokine transcripts, with clear biases on the basis of ancestry, and following patterns more complex than simple T[subscript H]1/2/17 partitions. We identified 39 genetic loci specifically associated in cis with activated gene expression. We further fine-mapped and validated a single-base variant that modulates YY1 binding and the activity of an enhancer element controlling the autoimmune-associated IL2RA gene, affecting its activity in activated but not regulatory T cells. Thus, interindividual variability affects the fundamental immunologic process of T helper activation, with important connections to autoimmune disease.

Published
2016

3. Erratum: Consortium biology in immunology: The perspective from the Immunological Genome Project

Author

Benoist, C, Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Morvan, M, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T, Wagers, A, Benoist, C, Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Morvan, M, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T, and Wagers, A

Published
2014

4. Erratum: Consortium biology in immunology: The perspective from the Immunological Genome Project

Author

Benoist, C, Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Morvan, M, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T, Wagers, A, Benoist, C, Benoist, C, Lanier, L, Merad, M, Mathis, D, Ericson, J, Painter, M, Davis, S, Laplace, C, Hyatt, G, Paik, H, Rothamel, K, Cruse, R, Doran, G, Heng, T, Asinovski, N, Ortiz-Lopes, A, Ergun, A, Gray, D, Wakamatsu, E, Hill, J, Mingueneau, M, Cipolletta, D, Yoshida, H, Cohen, N, Kim, E, Brennan, P, Lynch, L, Brenner, M, Costello, J, Collins, JJ, Blair, D, Dustin, M, Knell, J, Yang, E, Best, A, Shaw, L, Doedens, A, Goldrath, A, Shinton, S, Zhou, Y, Hardy, R, Jojic, V, Mostafavi, S, Koller, D, Jianu, R, Laidlaw, D, Bezman, N, Sun, J, Zhu, Y, Hendricks, D, Kamimura, Y, Min-Oo, G, Morvan, M, Nabekura, T, Lam, V, Kim, C, Greter, M, Helft, J, Chow, A, Bogunovic, M, Mortha, A, Price, J, Hashimoto, D, Miller, J, Sathe, P, Chudnovskiy, A, Lavin, Y, Idoyaga, J, Gautier, E, Jakubzick, C, D'Angelo, J, Randolph, G, Shay, T, Regev, A, Gazit, R, Rossi, D, Kreslawsky, T, von Bohmer, H, Bellemare-Pelletier, A, Elpek, K, Spelv, L, Fletcher, A, Malhotra, D, Cremasco, V, Turley, S, Kim, F, Nageswara Rao, T, and Wagers, A

Published
2014

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