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Since Brazil's major energy resources are renewable and directly related to climate factors, it is among the countries most likely of being affected by climate change. Given Brazil's high hydropower storage capacity and the strong seasonal patterns of its renewable resources, introducing Seasonal Pumped Hydropower Storage (SPHS) can help mitigate these challenges. To this end, a methodology is proposed that links the dynamic system-optimization model – MESSAGEix - to regional climate model simulations, called the Brazilian Electricity System MESSAGEix Model (BESMM). This model, with its detailed hydropower representation, is capable of integrating data from three climate change scenarios with the country's energy system. Climate change introduces a new dimension to this approach, as there is evidence of increasing the seasonal imbalance of variable renewable resources in Brazil. BESMM results suggest that SPHS can play a fundamental role in achieving a 100 % renewable matrix by 2100 in RCP 2.6 scenario, as well as enhancing the renewable energy endowment in scenarios RCP 4.5 and RCP 8.5. A reduction of up to 68 % of CO2 emissions is predicted in scenarios incorporating SPHS, compared to scenarios without SPHS.

Since Brazil's major energy resources are renewable and directly related to climate factors, it is among the countries most likely of being affected by climate change. Given Brazil's high hydropower storage capacity and the strong seasonal patterns of its renewable resources, introducing Seasonal Pumped Hydropower Storage (SPHS) can help mitigate these challenges. To this end, a methodology is proposed that links the dynamic system-optimization model – MESSAGEix - to regional climate model simulations, called the Brazilian Electricity System MESSAGEix Model (BESMM). This model, with its detailed hydropower representation, is capable of integrating data from three climate change scenarios with the country's energy system. Climate change introduces a new dimension to this approach, as there is evidence of increasing the seasonal imbalance of variable renewable resources in Brazil. BESMM results suggest that SPHS can play a fundamental role in achieving a 100 % renewable matrix by 2100 in RCP 2.6 scenario, as well as enhancing the renewable energy endowment in scenarios RCP 4.5 and RCP 8.5. A reduction of up to 68 % of CO2 emissions is predicted in scenarios incorporating SPHS, compared to scenarios without SPHS.

Since Brazil's major energy resources are renewable and directly related to climate factors, it is among the countries most likely of being affected by climate change. Given Brazil's high hydropower storage capacity and the strong seasonal patterns of its renewable resources, introducing Seasonal Pumped Hydropower Storage (SPHS) can help mitigate these challenges. To this end, a methodology is proposed that links the dynamic system-optimization model – MESSAGEix - to regional climate model simulations, called the Brazilian Electricity System MESSAGEix Model (BESMM). This model, with its detailed hydropower representation, is capable of integrating data from three climate change scenarios with the country's energy system. Climate change introduces a new dimension to this approach, as there is evidence of increasing the seasonal imbalance of variable renewable resources in Brazil. BESMM results suggest that SPHS can play a fundamental role in achieving a 100 % renewable matrix by 2100 in RCP 2.6 scenario, as well as enhancing the renewable energy endowment in scenarios RCP 4.5 and RCP 8.5. A reduction of up to 68 % of CO2 emissions is predicted in scenarios incorporating SPHS, compared to scenarios without SPHS.

Infectious bursal disease virus (IBDV) vaccines do not induce sterilizing immunity, and vaccinated birds can become infected with field strains. Vaccine-induced immune selection pressure drives the evolution of antigenic drift variants that accumulate amino acid changes in the hypervariable region (HVR) of the VP2 capsid, which may lead to vaccine failures. However, there is a lack of information regarding how quickly mutations arise, and the relative contribution different residues make to immune escape. To model IBDV antigenic drift in vitro, we serially passaged a classical field strain belonging to genogroup A1 (F52/70) ten times, in triplicate, in the immortalized chicken B cell line, DT40, in the presence of sub-neutralizing concentrations of sera from birds inoculated with IBDV vaccine strain 2512, to generate escape mutants. This assay simulated a situation where classical strains may infect birds that have suboptimal vaccine-induced antibody responses. We then sequenced the HVR of the VP2 capsid at passage (P) 5 and 10 and compared the sequences to the parental virus (P0), and to the virus passaged in the presence of negative control chicken serum that lacked IBDV antibodies. Two escape mutants at P10 had the same mutations, D279Y and G281R, and a third had mutations S251I and D279N. Furthermore, at P5, the D279Y mutation was detectable, but the G281R mutation was not, indicating the mutations arose with different kinetics.

In order to better understand differences in the outcome of infectious bursal disease virus (IBDV) infection, we inoculated a very virulent (vv) strain into White Leghorn chickens of inbred line W that was previously reported to experience over 24% flock mortality, and three inbred lines (15I, C.B4 and 0) that were previously reported to display no mortality. Within each experimental group, some individuals experienced more severe disease than others but line 15I birds experienced milder disease based on average clinical scores, percentage of birds with gross pathology, average bursal lesion scores and average peak bursal virus titre. RNA-Seq analysis revealed that more severe disease in line W was associated with significant up-regulation of pathways involved in inflammation, cytoskeletal regulation by Rho GTPases, nicotinic acetylcholine receptor signaling, and Wnt signaling in the bursa compared to line 15I. Primary bursal cell populations isolated from uninfected line W birds contained a significantly greater percentage of KUL01+ macrophages than cells isolated from line 15I birds (p < 0.01) and, when stimulated ex vivo with LPS, showed more rapid up-regulation of pro-inflammatory gene expression than those from line 15I birds. We hypothesize that a more rapid induction of pro-inflammatory cytokine responses in bursal cells following IBDV infection leads to more severe disease in line W birds than in line 15I.