1. Can computer-aided diagnosis assist in the identification of prostate cancer on prostate MRI? a multi-center, multi-reader investigation
- Author
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Gaur, S., Lay, N., Harmon, S.A., Doddakashi, S., Mehralivand, S., Argun, B., Barrett, T., Bednarova, S., Girometti, R., Karaarslan, E., Kural, A.R., Oto, A., Purysko, A.S., Antic, T., Magi-Galluzzi, C., Saglican, Y., Sioletic, S., Warren, A.Y., Bittencourt, L., Futterer, J.J., Gupta, R.T., Kabakus, I., Law, Y.M., Margolis, D.J., Shebel, H., Westphalen, A.C., Wood, B.J., Pinto, P.A., Shih, J.H., Choyke, P.L., Summers, R.M., Turkbey, B., Gaur, S., Lay, N., Harmon, S.A., Doddakashi, S., Mehralivand, S., Argun, B., Barrett, T., Bednarova, S., Girometti, R., Karaarslan, E., Kural, A.R., Oto, A., Purysko, A.S., Antic, T., Magi-Galluzzi, C., Saglican, Y., Sioletic, S., Warren, A.Y., Bittencourt, L., Futterer, J.J., Gupta, R.T., Kabakus, I., Law, Y.M., Margolis, D.J., Shebel, H., Westphalen, A.C., Wood, B.J., Pinto, P.A., Shih, J.H., Choyke, P.L., Summers, R.M., and Turkbey, B.
- Abstract
Contains fulltext : 199964.pdf (Publisher’s version ) (Open Access), For prostate cancer detection on prostate multiparametric MRI (mpMRI), the Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) and computer-aided diagnosis (CAD) systems aim to widely improve standardization across radiologists and centers. Our goal was to evaluate CAD assistance in prostate cancer detection compared with conventional mpMRI interpretation in a diverse dataset acquired from five institutions tested by nine readers of varying experience levels, in total representing 14 globally spread institutions. Index lesion sensitivities of mpMRI-alone were 79% (whole prostate (WP)), 84% (peripheral zone (PZ)), 71% (transition zone (TZ)), similar to CAD at 76% (WP, p=0.39), 77% (PZ, p=0.07), 79% (TZ, p=0.15). Greatest CAD benefit was in TZ for moderately-experienced readers at PI-RADSv2 <3 (84% vs mpMRI-alone 67%, p=0.055). Detection agreement was unchanged but CAD-assisted read times improved (4.6 vs 3.4 minutes, p<0.001). At PI-RADSv2 >/= 3, CAD improved patient-level specificity (72%) compared to mpMRI-alone (45%, p<0.001). PI-RADSv2 and CAD-assisted mpMRI interpretations have similar sensitivities across multiple sites and readers while CAD has potential to improve specificity and moderately-experienced radiologists' detection of more difficult tumors in the center of the gland. The multi-institutional evidence provided is essential to future prostate MRI and CAD development.
- Published
- 2018