Search

The stories told within a society about migration and migrants paint a rich picture of how its members view the opportunities and challenges associated with the movement of people, and through what lenses. These migration narratives both inform policymaking and shape the public's reaction to government policy, affecting the policies' chances of achieving their goals.While El Salvador, Guatemala, and Honduras are primarily known for emigration to the United States and Mexico, these northern Central American countries have seen notable changes in migration trends in recent years. The number of migrants from South America and the Caribbean who transit through these countries on their way north has increased, as has the number of Central Americans returning to their countries of origin.

The stories told within a society about migration and migrants paint a rich picture of how its members view the opportunities and challenges associated with the movement of people, and through what lenses. These migration narratives both inform policymaking and shape the public's reaction to government policy, affecting the policies' chances of achieving their goals.While El Salvador, Guatemala, and Honduras are primarily known for emigration to the United States and Mexico, these northern Central American countries have seen notable changes in migration trends in recent years. The number of migrants from South America and the Caribbean who transit through these countries on their way north has increased, as has the number of Central Americans returning to their countries of origin.

The stories told within a society about migration and migrants paint a rich picture of how its members view the opportunities and challenges associated with the movement of people, and through what lenses. These migration narratives both inform policymaking and shape the public's reaction to government policy, affecting the policies' chances of achieving their goals.While El Salvador, Guatemala, and Honduras are primarily known for emigration to the United States and Mexico, these northern Central American countries have seen notable changes in migration trends in recent years. The number of migrants from South America and the Caribbean who transit through these countries on their way north has increased, as has the number of Central Americans returning to their countries of origin.

We present a novel mathematical formalism to predict the kinetics of DNA damage repair after exposure to both low- and high-LET radiation (X rays; 350 MeV/n 40Ar; 600 MeV/n 56Fe). Our method is based on monitoring DNA damage repair protein 53BP1 that forms radiation-induced foci (RIF) at locations of DNA double-strand breaks (DSB) in the nucleus and comparing its expression in primary skin fibroblasts isolated from 15 mice strains. We previously reported strong evidence for clustering of nearby DSB into single repair units as opposed to the classic "contact-first" model where DSB are considered immobile. Here we apply this clustering model to evaluate the number of remaining RIF over time. We also show that the newly introduced kinetic metrics can be used as surrogate biomarkers for in vivo radiation toxicity, with potential applications in radiotherapy and human space exploration. In particular, we observed an association between the characteristic time constant of RIF repair measured in vitro and survival levels of immune cells collected from irradiated mice. Moreover, the speed of DNA damage repair correlated not only with radiation-induced cellular survival in vivo, but also with spontaneous cancer incidence data collected from the Mouse Tumor Biology database, suggesting a relationship between the efficiency of DSB repair after irradiation and cancer risk.

We present a novel mathematical formalism to predict the kinetics of DNA damage repair after exposure to both low- and high-LET radiation (X rays; 350 MeV/n 40Ar; 600 MeV/n 56Fe). Our method is based on monitoring DNA damage repair protein 53BP1 that forms radiation-induced foci (RIF) at locations of DNA double-strand breaks (DSB) in the nucleus and comparing its expression in primary skin fibroblasts isolated from 15 mice strains. We previously reported strong evidence for clustering of nearby DSB into single repair units as opposed to the classic "contact-first" model where DSB are considered immobile. Here we apply this clustering model to evaluate the number of remaining RIF over time. We also show that the newly introduced kinetic metrics can be used as surrogate biomarkers for in vivo radiation toxicity, with potential applications in radiotherapy and human space exploration. In particular, we observed an association between the characteristic time constant of RIF repair measured in vitro and survival levels of immune cells collected from irradiated mice. Moreover, the speed of DNA damage repair correlated not only with radiation-induced cellular survival in vivo, but also with spontaneous cancer incidence data collected from the Mouse Tumor Biology database, suggesting a relationship between the efficiency of DSB repair after irradiation and cancer risk.

Examines the achievement results and operations of five Knowledge Is Power Program middle schools to assess the program's effectiveness, the role of leadership, implementation of the KIPP culture, design of curricula and instruction, and lessons learned.

Provides an overview of K-12 arts education, including course offerings; availability of teachers, facilities, and materials; standards alignment, assessment, and accountability practices; and equal access. Discusses barriers and recommendations.

Provides an overview of K-12 arts education, including course offerings; availability of teachers, facilities, and materials; standards alignment, assessment, and accountability practices; and equal access. Discusses barriers and recommendations.

Provides an overview of K-12 arts education, including course offerings; availability of teachers, facilities, and materials; standards alignment, assessment, and accountability practices; and equal access. Discusses barriers and recommendations.

Provides an overview of K-12 arts education, including course offerings; availability of teachers, facilities, and materials; standards alignment, assessment, and accountability practices; and equal access. Discusses barriers and recommendations.

Measures how well five San Francisco Bay Area schools have implemented the goals of the Knowledge Is Power Program during the first year of a three-year initiative to prepare underserved urban youth for college.