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Addressing large bone segmental defects remains a profound challenge in orthopaedic surgery, demanding graft designs that mirror patient-specific defects while ensuring vascularization, osteoconduction, and structural integrity. Conventional approaches fall short in achieving this level of customization and functionality. This work leverages fuse filament fabrication (FFF) to fabricate innovative yttria stabilize zirconia graft designs that combine several strategies to tackle these multifaceted challenges. Graft designs ingeniously incorporate dense and porous structures mimicking the intricate architecture of natural bone for improved structural integrity and different ridges and protrusions to enhance the fixation. Additionally, these grafts undergo infiltration with PCL/PVA/AgNPs composite polymers, enriching biocompatibility, structural integrity, and antibacterial properties, fostering conducive conditions for optimal bone growth. Attaining printable filaments with YSZ powders below 50 nm and loads reaching 50 vol% marks a pioneering advancement in bone graft fabrication via Fused Filament Fabrication (FFF). This enabled high densification and low grain size at reduced sintering temperatures, imperative to achieve high mechanical performance. The biodegradation capacity of biopolymers in PBS and their role in the mechanical behaviour of grafts have been assessed, demonstrating the beneficial potential of the multicomponent graft proposed reaching strength values of 90–105 MPa.

Geomorphometry plays a fundamental role in the study and analysis of the earth's surface, providing a conceptual and methodological basis for understanding the characteristics of the physical environment. In this context, the Grijalva and Usumacinta River basins (CGyU), shared by Mexico, Guatemala, and Belize, stand out for their water abundance, natural richness, and high vulnerability to extreme hydrometeorological events. The main objective of this research is the geomorphometric characterization of the CGyU. For this purpose, hierarchical classification was developed using Hammond's method and the process was automated using Geographic Information Systems (GIS) adapted by Dikau. The results revealed the existence of five main classes and eighteen subclasses of landforms in both watersheds. Based on these findings, we can conclude that the methodology employed proved to be reliable for describing landforms in these watersheds. Therefore, this study contributes to new research and the implementation of public policies related to land use planning, civil protection, and biodiversity, among others., La geomorfometría desempeña un papel fundamental en el estudio y análisis de la superficie terrestre, proporcionando una base conceptual y metodológica para comprender las características del medio físico. En este contexto, las cuencas del río Grijalva y Usumacinta (CGyU), compartidas por México, Guatemala y Belice, destacan por su abundancia hídrica, riqueza natural y alta vulnerabilidad a los eventos hidrometeorológicos extremos. El objetivo principal de esta investigación es la caracterización geomorfométrica de las CGyU. Para ello, se desarrolló la clasificación jerárquica mediante el método de Hammond y se automatizó el proceso utilizando Sistemas de Información Geográfica (SIG) adaptada por Dikau. Los resultados revelaron la existencia de cinco clases principales y dieciocho subclases de formas del terreno en ambas cuencas. Con base en estos hallazgos, podemos concluir que la metodología empleada demostró ser confiable para describir las formas del terreno en estas cuencas. Por tanto, este estudio contribuye al desarrollo de nuevas investigaciones y a la implementación de políticas públicas relacionadas al ordenamiento territorial, la protección civil, la biodiversidad.

En los últimos años ha habido un rápido avance en la digitalización del sector educativo, impulsado en gran medida por la aparición de numerosas plataformas digitales en la industria de la tecnología educativa. Estas plataformas ofrecen enseñanza activa con un enfoque pedagógico centrado en el estudiante, que permite acelerar y consolidar su aprendizaje. Una novedosa plataforma dentro de estas Tecnologías de la Información y las Comunicaciones es Wooclap; una herramienta de dinamización online que facilita al docente el diseño de actividades mediante preguntas interactivas, con la obtención de las evaluaciones en tiempo real. El uso de esta herramienta en el contexto universitario es reciente, por ello, un grupo de profesoras de distintos departamentos de la Facultad de Medicina, junto con una médico intensivista del Hospital San Carlos solicitaron un Proyecto de Innovación en la modalidad Innova-Docentia para valorar la utilidad y grado de satisfacción que perciben estudiantes de cuatro grados distintos de Ciencias de la Salud de la Universidad Complutense de Madrid respecto al uso de la herramienta. Durante el curso académico 2023-2024 se desarrolló la actividad, y facilitó la encuesta de satisfacción. Los resultados indican que la herramienta es considerada sencilla e intuitiva en su utilización, y se valora positivamente la amplia gama de tipología de preguntas que ofrece. Los discentes indican mayoritariamente que el empleo de Wooclap favorece su motivación y atención durante las clases, y utilidad para el repaso de contenidos y el aprendizaje de la asignatura, por lo que recomiendan su empleo en otras asignaturas. Por lo tanto, la herramienta digital Wooclap cumple con las expectativas, fomentando la participación de los estudiantes en el aula y proporcionando una herramienta adicional que facilita el aprendizaje de los estudiantes.

The incidence of fractures and bone defects has been a significant driving force behind research efforts aimed at enhancing the quality of life for patients. However, it is important to acknowledge the inherent complexities of this research field. Where each patient could have different scenarios along with the difficulty of replicate the properties and complex design of the bones. In this study, scaffolds previously manufactured by different 3D printing techniques made of ceramic materials, specifically yttria-stabilised zirconia, which has excellent biocompatibility and mechanical properties, were used. These samples, which exhibit different designs to be employed in specific medical situation, have been characterised according to his morphology and porosity; using the outcomes for select the most promising for subsequent infiltration with appropriate biopolymers in order to improve their in vivo performance. Specifically oriented towards improve the osseointegration capacity by adding nanohydroxyapatite (nHA). The infiltrated samples were evaluated in terms of polymer degradation inside the composite, swelling evaluation, and studies of apatite formation capacity on the surface (bioactivity) assessed through XRD.

The demand for dental implants is increasing, although there is a wide variety of implants currently available in the market, it is necessary to implement improvements in their design and/or the selection of materials used. The development of biomimetic and bioactive Ti scaffolds for bone regeneration is necessary. In this context, this article proposes the design, manufacture and characterization of a porous titanium implant with the aim of eliminating some of the deficiencies found in commercially available titanium implants. Stress-shielding and the lack of osseointegration or bacterial infection are still some limitations to solve. Porous samples were produced using conventional Powder Metallurgy (PM) and the space holder (SH) technique. Ammonium bicarbonate particles were used as spacers in size ranges of 100–200 µm. The porosity and surface characterization were performed by Archimedes’ method and image analysis, while the mechanical behavior was analyzed by micro-mechanical testing. After that, the micromachining protocol of the implant is carried out. Substrates were chemically etched by immersion in fluorhydric acid at different times (15 s; 60 s and 125 s) to achieve a suitable surface roughness with biofunctional balance. Results showed that it is possible to obtain a desired longitudinal gradient. The optimized method described in this work suggests that it is a reasonable candidate for the development of dental implants with a good balance between reduced stress shielding and adequate mechanical strength.

Addressing large bone segmental defects remains a profound challenge in orthopaedic surgery, demanding graft designs that mirror patient-specific defects while ensuring vascularization, osteoconduction, and structural integrity. Conventional approaches fall short in achieving this level of customization and functionality. This work leverages fuse filament fabrication (FFF) to fabricate innovative yttria stabilize zirconia graft designs that combine several strategies to tackle these multifaceted challenges. Graft designs ingeniously incorporate dense and porous structures mimicking the intricate architecture of natural bone for improved structural integrity and different ridges and protrusions to enhance the fixation. Additionally, these grafts undergo infiltration with PCL/PVA/AgNPs composite polymers, enriching biocompatibility, structural integrity, and antibacterial properties, fostering conducive conditions for optimal bone growth. Attaining printable filaments with YSZ powders below 50 nm and loads reaching 50 vol% marks a pioneering advancement in bone graft fabrication via Fused Filament Fabrication (FFF). This enabled high densification and low grain size at reduced sintering temperatures, imperative to achieve high mechanical performance. The biodegradation capacity of biopolymers in PBS and their role in the mechanical behaviour of grafts have been assessed, demonstrating the beneficial potential of the multicomponent graft proposed reaching strength values of 90–105 MPa.

Addressing large bone segmental defects remains a profound challenge in orthopaedic surgery, demanding graft designs that mirror patient-specific defects while ensuring vascularization, osteoconduction, and structural integrity. Conventional approaches fall short in achieving this level of customization and functionality. This work leverages fuse filament fabrication (FFF) to fabricate innovative yttria stabilize zirconia graft designs that combine several strategies to tackle these multifaceted challenges. Graft designs ingeniously incorporate dense and porous structures mimicking the intricate architecture of natural bone for improved structural integrity and different ridges and protrusions to enhance the fixation. Additionally, these grafts undergo infiltration with PCL/PVA/AgNPs composite polymers, enriching biocompatibility, structural integrity, and antibacterial properties, fostering conducive conditions for optimal bone growth. Attaining printable filaments with YSZ powders below 50 nm and loads reaching 50 vol% marks a pioneering advancement in bone graft fabrication via Fused Filament Fabrication (FFF). This enabled high densification and low grain size at reduced sintering temperatures, imperative to achieve high mechanical performance. The biodegradation capacity of biopolymers in PBS and their role in the mechanical behaviour of grafts have been assessed, demonstrating the beneficial potential of the multicomponent graft proposed reaching strength values of 90–105 MPa.

In this work, the strength-to-weight ratio on I-beam of a cotton-glass fibers hybrid composite (64% cotton fibers and 36% glass fibers) was assessed. Numerical simulations were carried out under flexural loads and a flexural test were carried out using a Shimadzu AG-X plus 100kN testing machine. The results showed that it is possible to obtain an optimized geometry within the beam through the strategic removal of material zones without compromising the structural integrity. Furthermore, the flexural test on the composite beam showed a higher value in the strength/weight ratio (44) compared to the optimized 6061-T6 aluminum beam (39.65); this behavior can be explained because fiber-reinforced composites are generally less dense compared to metals, and to the distribution of cotton and glass fibers within the beam., En este trabajo se presenta resultados sobre la evaluación de la resistencia/peso en una viga tipo I de material compuesto híbrido con fibras de algodón/vidrio (64% fibras de algodón y 36% fibras de vidrio). Se realizaron simulaciones numéricas a flexión a través del programa ANSYS y una prueba experimental a flexión en la máquina de ensayos Shimadzu AG-Xplus 100kN. Los resultados mostraron que es posible obtener una geometría optimizada dentro de la viga a través de la remoción estratégica de zonas de material sin comprometer la integridad estructural. Además, la prueba experimental a flexión en la viga de material compuesto mostró un valor superior en la relación de resistencia/peso (44) en comparación con la viga optimizada de aluminio 6061-T6 (39.65); este comportamiento se atribuye a que los materiales compuestos reforzados con fibras son generalmente menos densos en comparación con los metales, y a la distribución de las fibras de algodón y vidrio dentro de la viga.

In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

n industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

n industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its form of administration (selenite or Se nanoparticles (SeNPs). Despite this effect being related to oxidative, insulin-signaling and autophagy processes, the whole mechanism is not elucidated. The microbiota–liver–bile salts secretion axis is related to lipid homeostasis and adipose tissue development. Therefore, the colonic microbiota and total bile salts homeostasis were explored in four experimental groups of male adolescent rats: control, low-sodium selenite supplementation, low SeNP supplementation and moderate SeNPs supplementation. SeNPs were obtained by reducing Se tetrachloride in the presence of ascorbic acid. Supplementation was received orally through water intake; low-Se rats received twice more Se than control animals and moderate-Se rats tenfold more. Supplementation with low doses of Se clearly affected anaerobic colonic microbiota profile and bile salts homeostasis. However, these effects were different depending on the Se administration form. Selenite supplementation primarily affected liver by decreasing farnesoid X receptor hepatic function, leading to the accumulation of hepatic bile salts together to increase in the ratio Firmicutes/Bacteroidetes and glucagon-like peptide-1 (GLP-1) secretion. In contrast, low SeNP levels mainly affected microbiota, moving them towards a more prominent Gram-negative profile in which the relative abundance of Akkermansia and Muribaculaceae was clearly enhanced and the Firmicutes/Bacteroidetes ratio decreased. This bacterial profile is directly related to lower adipose tissue mass. Moreover, low SeNP administration did not modify bile salts pool in serum circulation. In addition, specific gut microbiota was regulated upon administration of low l

Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. For example, the development of novel drug delivery systems in the form of nanoparticles is improving the liberation, absorption, distribution, metabolism, and excretion (LADME) properties of the derived formulations, with a consequent enhancement in the treatment efficacy, a reduction in the secondary effects, and an increase in compliance with the dosage guidelines. Additionally, the use of biocompatible scaffolds is translating into the possibility of regenerating biological tissues. Personalized medicine is also benefiting from the advantages offered by additive manufacturing. However, all these areas have in common the need to develop novel materials or composites that fulfill the requirements of each application. Therefore, the aim of this Special Issue was to identify novel materials/composites that have been developed with specific characteristics for the designed biomedical application.

In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

n industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. For example, the development of novel drug delivery systems in the form of nanoparticles is improving the liberation, absorption, distribution, metabolism, and excretion (LADME) properties of the derived formulations, with a consequent enhancement in the treatment efficacy, a reduction in the secondary effects, and an increase in compliance with the dosage guidelines. Additionally, the use of biocompatible scaffolds is translating into the possibility of regenerating biological tissues. Personalized medicine is also benefiting from the advantages offered by additive manufacturing. However, all these areas have in common the need to develop novel materials or composites that fulfill the requirements of each application. Therefore, the aim of this Special Issue was to identify novel materials/composites that have been developed with specific characteristics for the designed biomedical application.

n industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its form of administration (selenite or Se nanoparticles (SeNPs). Despite this effect being related to oxidative, insulin-signaling and autophagy processes, the whole mechanism is not elucidated. The microbiota–liver–bile salts secretion axis is related to lipid homeostasis and adipose tissue development. Therefore, the colonic microbiota and total bile salts homeostasis were explored in four experimental groups of male adolescent rats: control, low-sodium selenite supplementation, low SeNP supplementation and moderate SeNPs supplementation. SeNPs were obtained by reducing Se tetrachloride in the presence of ascorbic acid. Supplementation was received orally through water intake; low-Se rats received twice more Se than control animals and moderate-Se rats tenfold more. Supplementation with low doses of Se clearly affected anaerobic colonic microbiota profile and bile salts homeostasis. However, these effects were different depending on the Se administration form. Selenite supplementation primarily affected liver by decreasing farnesoid X receptor hepatic function, leading to the accumulation of hepatic bile salts together to increase in the ratio Firmicutes/Bacteroidetes and glucagon-like peptide-1 (GLP-1) secretion. In contrast, low SeNP levels mainly affected microbiota, moving them towards a more prominent Gram-negative profile in which the relative abundance of Akkermansia and Muribaculaceae was clearly enhanced and the Firmicutes/Bacteroidetes ratio decreased. This bacterial profile is directly related to lower adipose tissue mass. Moreover, low SeNP administration did not modify bile salts pool in serum circulation. In addition, specific gut microbiota was regulated upon administration of low l

n industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

This article presents the results of research on the indigenous languages of Tabasco and their importance, exploring the opinions of students in the Language Bachelor's program at the Univerdad Juárez Autónoma de Tabasco. The aim was to determine whether these students have an interest in learning a native language from their state. The value of indigenous languages as an essential part of the regional cultural and social heritage was emphasized. The research employed a mixed-method approach, using two data collection methods. The first was a questionnaire that gathered information about students' interest in learning an indigenous language and their perception of the importance of preserving them. The second method involved interviewing a student who is a native speaker of an indigenous language in Tabasco. This interview provided a more detailed insight into the personal experience and opinions of someone with active proficiency in an indigenous language in the region. The research findings highlight the need to promote the preservation and revitalization of indigenous languages in Tabasco, involving the student language community. Furthermore, they underscore the importance of recognizing and valuing these languages as part of the cultural and linguistic identity of the region., Este artículo presenta los resultados de una investigación sobre las lenguas indígenas de Tabasco y su importancia, explorando las opiniones de estudiantes de la Licenciatura en Idiomas de la Universidad Juárez Autónoma de Tabasco. El objetivo fue determinar si dichos estudiantes tienen interés en aprender una lengua originaria de su estado. Se resaltó el valor de las lenguas indígenas como parte esencial del patrimonio cultural y social regional. La investigación utilizó un enfoque mixto, empleando dos métodos de recopilación de datos. El primero fue un cuestionario que recabó información sobre el interés de los estudiantes en aprender una lengua indígena y su percepción de la importancia de preservarlas. El segundo método consistió en entrevistar a una estudiante hablante nativa de una lengua indígena en Tabasco. Esta entrevista proporcionó una visión más detallada de la experiencia personal y opiniones de alguien con dominio activo de una lengua indígena en la región. Los hallazgos de la investigación destacan la necesidad de promover la preservación y revitalización de las lenguas indígenas en Tabasco, involucrando a la comunidad estudiantil de idiomas. Además, resaltan la importancia de reconocer y valorar estas lenguas como parte de la identidad cultural y lingüística de la región.

Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its form of administration (selenite or Se nanoparticles (SeNPs). Despite this effect being related to oxidative, insulin-signaling and autophagy processes, the whole mechanism is not elucidated. The microbiota–liver–bile salts secretion axis is related to lipid homeostasis and adipose tissue development. Therefore, the colonic microbiota and total bile salts homeostasis were explored in four experimental groups of male adolescent rats: control, low-sodium selenite supplementation, low SeNP supplementation and moderate SeNPs supplementation. SeNPs were obtained by reducing Se tetrachloride in the presence of ascorbic acid. Supplementation was received orally through water intake; low-Se rats received twice more Se than control animals and moderate-Se rats tenfold more. Supplementation with low doses of Se clearly affected anaerobic colonic microbiota profile and bile salts homeostasis. However, these effects were different depending on the Se administration form. Selenite supplementation primarily affected liver by decreasing farnesoid X receptor hepatic function, leading to the accumulation of hepatic bile salts together to increase in the ratio Firmicutes/Bacteroidetes and glucagon-like peptide-1 (GLP-1) secretion. In contrast, low SeNP levels mainly affected microbiota, moving them towards a more prominent Gram-negative profile in which the relative abundance of Akkermansia and Muribaculaceae was clearly enhanced and the Firmicutes/Bacteroidetes ratio decreased. This bacterial profile is directly related to lower adipose tissue mass. Moreover, low SeNP administration did not modify bile salts pool in serum circulation. In addition, specific gut microbiota was regulated upon administration of low l

Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. For example, the development of novel drug delivery systems in the form of nanoparticles is improving the liberation, absorption, distribution, metabolism, and excretion (LADME) properties of the derived formulations, with a consequent enhancement in the treatment efficacy, a reduction in the secondary effects, and an increase in compliance with the dosage guidelines. Additionally, the use of biocompatible scaffolds is translating into the possibility of regenerating biological tissues. Personalized medicine is also benefiting from the advantages offered by additive manufacturing. However, all these areas have in common the need to develop novel materials or composites that fulfill the requirements of each application. Therefore, the aim of this Special Issue was to identify novel materials/composites that have been developed with specific characteristics for the designed biomedical application.

In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

Currently, the field of medicine is drastically advancing, mainly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. For example, the development of novel drug delivery systems in the form of nanoparticles is improving the liberation, absorption, distribution, metabolism, and excretion (LADME) properties of the derived formulations, with a consequent enhancement in the treatment efficacy, a reduction in the secondary effects, and an increase in compliance with the dosage guidelines. Additionally, the use of biocompatible scaffolds is translating into the possibility of regenerating biological tissues. Personalized medicine is also benefiting from the advantages offered by additive manufacturing. However, all these areas have in common the need to develop novel materials or composites that fulfill the requirements of each application. Therefore, the aim of this Special Issue was to identify novel materials/composites that have been developed with specific characteristics for the designed biomedical application.

Crops in the state of Campeche are intensifying, this causes transformations in the physicochemical and biological properties of the soil. The objective was to determine the effect of agroecosystems on soil macrofauna and soil properties. Ten sampling points per agroecosystem were taken, with three repetitions each.The sites were chosen according totheagricultural use (grassland, forest, intensive and traditional agricultural) and time of use (≥8 years). One kilogram from each sample was taken at a depth of 20 cm, then placed in polyethylene bags. The pH, electrical conductivity, organic matter, available phosphorus, total nitrogen and soil macrofauna were determined. With the data of each variable, an analysis of variance was performed and to determine the differences between land uses and sites, a mean test was carried out according to the Tukey statistic (p≤ 0.05), using the software Statistica version 7.1. The grassland agroecosystem ofPalizada presented the best characteristics in the soils, with pH of 7.29, P, OM, N of 1.31 mg kg-1, 5.05% and 0.31%, respectively and soil fauna with 66 individuals. The agroecosystem with the lowest soil quality was intensive crops of Hopelchén, with moderately acidic pHs(6.44), higher amount of P (33.42 mg kg-1), lower OM(2.59%) and high N contents (0.23%) and without soil macrofauna. Soil management in agricultural agroecosystems does not favor the presence of soil macrofauna nor does it maintain the nutrients necessary for the proper functioning and quality of the soil, Los cultivos en el estado de Campeche se están intensificando, esto ocasiona transformaciones en las propiedades fisicoquímicas y biológicas del suelo. El objetivo fue determinar el efecto de los agroecosistemas sobre la macrofauna edáfica y las propiedades del suelo. Se tomaron 10 puntos de muestreo por agroecosistema, con tres repeticiones cada. Los sitios se escogieron de acuerdo con el uso agropecuarios (pastizal, monte, agrícola intensivo y tradicional) y tiempo de uso (≥8 años). Se tomó 1 kg de cada muestra a 20 cm de profundidad, colocadas posteriormente en bolsas de polietileno. Se determinó pH, conductividad eléctrica, materia orgánica, fósforo disponible, nitrógeno total y macrofauna edáfica. Con los datos de cada variable se realizó un análisis de varianza y para determinar las diferencias entre usos de suelo y sitios, se efectuó una prueba de medias según el estadístico de Tukey (p≤ 0.05), mediante el software Statistica versión 7.1. El agroecosistema Pastizal de Palizada presentó las mejores características en los suelos, con pH de 7.29, P, MO, N de 1.31 mg kg-1, 5.05% y 0.31%, respectivamente y fauna edáfica con 66 individuos. El agroecosistema con menor calidad en el suelo fue cultivos intensivos de Hopelchén, con pH moderadamente ácidos (6.44), mayor cantidad de P (33.42 mg kg-1), menor MO (2.59%) y contenidos elevados de N (0.23%) y sin macrofauna edáfica. El manejo del suelo en los agroecosistemas agrícolas no favorece la presencia de macrofauna edáfica ni mantiene los nutrientes necesarios para el buen funcionamiento y calidad de suelo.

This article presents the results of research on the indigenous languages of Tabasco and their importance, exploring the opinions of students in the Language Bachelor's program at the Univerdad Juárez Autónoma de Tabasco. The aim was to determine whether these students have an interest in learning a native language from their state. The value of indigenous languages as an essential part of the regional cultural and social heritage was emphasized. The research employed a mixed-method approach, using two data collection methods. The first was a questionnaire that gathered information about students' interest in learning an indigenous language and their perception of the importance of preserving them. The second method involved interviewing a student who is a native speaker of an indigenous language in Tabasco. This interview provided a more detailed insight into the personal experience and opinions of someone with active proficiency in an indigenous language in the region. The research findings highlight the need to promote the preservation and revitalization of indigenous languages in Tabasco, involving the student language community. Furthermore, they underscore the importance of recognizing and valuing these languages as part of the cultural and linguistic identity of the region., Este artículo presenta los resultados de una investigación sobre las lenguas indígenas de Tabasco y su importancia, explorando las opiniones de estudiantes de la Licenciatura en Idiomas de la Universidad Juárez Autónoma de Tabasco. El objetivo fue determinar si dichos estudiantes tienen interés en aprender una lengua originaria de su estado. Se resaltó el valor de las lenguas indígenas como parte esencial del patrimonio cultural y social regional. La investigación utilizó un enfoque mixto, empleando dos métodos de recopilación de datos. El primero fue un cuestionario que recabó información sobre el interés de los estudiantes en aprender una lengua indígena y su percepción de la importancia de preservarlas. El segundo método consistió en entrevistar a una estudiante hablante nativa de una lengua indígena en Tabasco. Esta entrevista proporcionó una visión más detallada de la experiencia personal y opiniones de alguien con dominio activo de una lengua indígena en la región. Los hallazgos de la investigación destacan la necesidad de promover la preservación y revitalización de las lenguas indígenas en Tabasco, involucrando a la comunidad estudiantil de idiomas. Además, resaltan la importancia de reconocer y valorar estas lenguas como parte de la identidad cultural y lingüística de la región.

In industries as diverse as automotive, aerospace, medical, energy, construction, electronics, and food, the engineering technology known as 3D printing or additive manufacturing facilitates the fabrication of rapid prototypes and the delivery of customized parts. This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It also provides a clear overview of the various 3D printing techniques used for producing parts and components in three dimensions. The application of these techniques in bioprinting and an up-to-date comprehensive review of their positive and negative aspects are covered, as well as the variety of materials used, with an emphasis on composites, hybrids, and smart materials. This article also provides an updated overview of 4D bioprinting technology, including biomaterial functions, bioprinting materials, and a targeted approach to various tissue engineering and regenerative medicine (TERM) applications. As a foundation for anticipated developments for TERM applications that could be useful for their successful usage in clinical settings, this article also examines present challenges and obstacles in 4D bioprinting technology. Finally, the article also outlines future regulations that will assist researchers in the manufacture of complex products and in the exploration of potential solutions to technological issues.

Despite the increasing progress achieved in the last 20 years in both the fabrication of porous dental implants and the development of new biopolymers for targeting drug therapy, there are important issues such as bone resorption, poor osseointegration, and bacterial infections that remain as critical challenges to avoid clinical failure problems. In this work, we present a novel microtechnology based on polycaprolactone microspheres that can adhere to porous titanium implant models obtained by the spacer holder technique to allow a custom biomechanical and biofunctional balance. For this purpose, a double emulsion solvent evaporation technique was successfully employed for the fabrication of the microparticles properly loaded with the antibacterial therapeutic agent, rose bengal. The resulting microspheres were infiltrated into porous titanium substrate and sintered at 60 °C for 1 h, obtaining a convenient prophylactic network. In fact, the sintered polymeric microparticles were demonstrated to be key to controlling the drug dissolution rate and favoring the early healing process as consequence of a better wettability of the porous titanium substrate to promote calcium phosphate nucleation. Thus, this joint technology proposes a suitable prophylactic tool to prevent both early-stage infection and late-stage osseointegration problems.

An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.

Biofortification has been widely used to increase mineral nutrients in staple foods, such as wheat (Triticum aestivum). In this study, a new approach has been used by analyzing the effect of inoculation with a plant growth-promoting rhizobacterium (PGPR), namely, Bacillus aryabhattai RSO25 and the addition of 1% (v/v) of organometallic Fe-containing polymeric nanoparticles (FeNPs) alone and in combination. Previously, the minimal inhibitory concentration of FeNPs for the bacterium was determined in order not to inhibit bacterial growth. All treatments had minor effects on seed germination and plant survival. Considering the physiology of plants, several photosynthetic parameters were significantly improved in individual treatments with FeNPs or the bacterium, particularly the efficiency of the photosystem II and the electron transport rate, which is indicative of a better photosynthetic performance. However, at the end of the experiment, a significant effect on final plant growth was not observed in shoots or in roots. When using FeNPs alone, earlier spike outgrow was observed and the final number of spikes increased by 20%. Concerning biofortification, FeNPs increased the concentration of Fe in spikes by 35%. In fact, the total amount of Fe per plant base rose to 215% with regard to the control. Besides, several side effects, such as increased Ca and decreased Na and Zn in spikes, were observed. Furthermore, the treatment with only bacteria decreased Na and Fe accumulation in grains, indicating its inconvenience. On its side, the combined treatment led to intermediate Fe accumulation in spikes, since an antagonist effect between RSO25 and FeNPs was observed. For this reason, the combined treatment was discouraged. In conclusion, of the three treatments tested, FeNPs alone is recommended for achieving efficient Fe biofortification in wheat.

En la actualidad el hambre y los malos hábitos alimenticios son un problema reconocido por la organización mundial de la salud (OMS). A pesar de todos los esfuerzos propuestos para solventar este problema, la OMS ha admitido que no se alcanzará el objetivo de hambre cero para 2030. Por todo esto y para aportar soluciones imaginativas a este problema, nos propusimos emplear nanopartículas poliméricas cargadas con zinc, junto con la bacteria Pantoea agglomerans, promotora de crecimiento de plantas (PGPR), para mejorar el valor nutricional de plantas como el trigo (Triticum aestivum), mediante bioforitficación. Las plantas de trigo fueron tratadas, tras su previa germinación, y se recogieron medidas de concentración de metales usando técnicas analíticas. Los resultados mostraron que los parámetros físicos y fisiológicos no se vieron afectados y se produjo una acumulación notoria del Zn en la parte aérea.

Despite the increasing progress achieved in the last 20 years in both the fabrication of porous dental implants and the development of new biopolymers for targeting drug therapy, there are important issues such as bone resorption, poor osseointegration, and bacterial infections that remain as critical challenges to avoid clinical failure problems. In this work, we present a novel microtechnology based on polycaprolactone microspheres that can adhere to porous titanium implant models obtained by the spacer holder technique to allow a custom biomechanical and biofunctional balance. For this purpose, a double emulsion solvent evaporation technique was successfully employed for the fabrication of the microparticles properly loaded with the antibacterial therapeutic agent, rose bengal. The resulting microspheres were infiltrated into porous titanium substrate and sintered at 60 °C for 1 h, obtaining a convenient prophylactic network. In fact, the sintered polymeric microparticles were demonstrated to be key to controlling the drug dissolution rate and favoring the early healing process as consequence of a better wettability of the porous titanium substrate to promote calcium phosphate nucleation. Thus, this joint technology proposes a suitable prophylactic tool to prevent both early-stage infection and late-stage osseointegration problems.

The use of porous titanium samples fabricated by space-holder powder metallurgy with bioactive coatings has already been reported to prevent resorption of the bone surrounding the implant and improve osseointegration, respectively. However, the presence of pores as well as the poor adherence and the brittle behavior inherent to glassy coatings affect the service behavior of implants fabricated from these samples. Therefore, they need to be optimized. In this work, 50 vol.% of porosity titanium substrates were manufactured with different pore range size (100–200 and 355–500 µm) spacer particles and coated with a bilayer of bioactive glasses (45S5/1393). The effect of the pores on the tribomechanical properties and infiltration of the bioactive glass 1393 along with the bioactivity of the bioactive glass 45S5 were evaluated by instrumented micro-indentation and scratch tests and the formation of hydroxyapatite in simulated body fluid. The results obtained were very promising as potential implants for the replacement of small tumors in cortical bone tissues, mainly due to the smaller pores that present an improved biomechanical and biofunctional balance.

Complexes {Ag[NHCMes,R]}n (R = H, 2a; Me, 2b and 2b’; iPr, 2c; iBu, 2d), were prepared by treatment of imidazolium precursor compounds [ImMes,R] (2-(3-mesityl-1H-imidazol-3-ium-1-yl)acetate, 1a, (S)-2-alkyl(3-mesityl-1H-imidazol-3-ium-1-yl)acetate, 1b–d, and (R)-2-methyl(3-mesityl-1H-imidazol-3-ium-1-yl)acetate, 1b’, with Ag2O under appropriate conditions. They were characterised by analytical, spectroscopic (IR, 1H, and 13C NMR and polarimetry), and X-ray methods (2a). In the solid state, 2a is a one-dimensional coordination polymer, in which the silver(I) cation is bonded to the carbene ligand and to the carboxylate group of a symmetry-related Ag[NHCMes,H] moiety. The coordination environment of the silver centre is well described by the DFT study of the dimeric model {Ag[NHCMes,H]}2. The antimicrobial properties of these complexes were evaluated versus Gram-negative bacteria E. coli and P. aeruginosa. From the observed MIC and MBC values (minimal inhibitory concentration and minimal bactericidal concentration, respectively), complex 2b’ showed the best antimicrobial properties (eutomer), which were significantly better than those of its enantiomeric derivative 2b (distomer). Additionally, analysis of MIC and MBC values of 2a–d reveal a clear structure–antimicrobial effect relationship. Antimicrobial activity decreases when the steric properties of the R alkyl group in {Ag[NHCMes,R]}n increase

Articular cartilage (AC) has a low ability for endogenous repair, and current treatments are not completely efficient in generating strong and healthy repair tissue. As a result, there is a great deal of interest in cartilage repair and recovery of joint function due to the aging population and the increasing frequency of cartilage degradation and osteoarthritis. Thus, the search for better and more efficient strategies to regenerate articular cartilage to repair the joints in patients with osteoarthritis is a critical motivation. Biomaterials, which are made of natural or synthetic polymers, or a mixture of the two, serve as a scaffold for tissue regeneration. Cartilage tissue engineering (TE) seeks to develop a treatment that can effectively repair damaged AC caused by trauma or disease. In cartilage TE, scaffolds that provide a 3D environment like native articular cartilage for cells to proliferate, attach, and hence ensure tissue regeneration success are needed. For optimal cell activities, which is associated with proper cartilage regeneration, these scaffolds must meet all necessary criteria, including adequate architectural, physicochemical, and biological properties. This study briefly explores the evolution of scaffolds constructed of synthetic polymers and hybrid materials for cartilage tissue engineering. Initially, general information on AC is presented, as well as a review of medical approaches to treating cartilage injuries or disease. Following that, the requirements for scaffolds in tissue regeneration, specific materials, and techniques for producing them are briefly discussed.

An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.

Biofortification has been widely used to increase mineral nutrients in staple foods, such as wheat (Triticum aestivum). In this study, a new approach has been used by analyzing the effect of inoculation with a plant growth-promoting rhizobacterium (PGPR), namely, Bacillus aryabhattai RSO25 and the addition of 1% (v/v) of organometallic Fe-containing polymeric nanoparticles (FeNPs) alone and in combination. Previously, the minimal inhibitory concentration of FeNPs for the bacterium was determined in order not to inhibit bacterial growth. All treatments had minor effects on seed germination and plant survival. Considering the physiology of plants, several photosynthetic parameters were significantly improved in individual treatments with FeNPs or the bacterium, particularly the efficiency of the photosystem II and the electron transport rate, which is indicative of a better photosynthetic performance. However, at the end of the experiment, a significant effect on final plant growth was not observed in shoots or in roots. When using FeNPs alone, earlier spike outgrow was observed and the final number of spikes increased by 20%. Concerning biofortification, FeNPs increased the concentration of Fe in spikes by 35%. In fact, the total amount of Fe per plant base rose to 215% with regard to the control. Besides, several side effects, such as increased Ca and decreased Na and Zn in spikes, were observed. Furthermore, the treatment with only bacteria decreased Na and Fe accumulation in grains, indicating its inconvenience. On its side, the combined treatment led to intermediate Fe accumulation in spikes, since an antagonist effect between RSO25 and FeNPs was observed. For this reason, the combined treatment was discouraged. In conclusion, of the three treatments tested, FeNPs alone is recommended for achieving efficient Fe biofortification in wheat.

The spread of antibiotic resistance among human and animal pathogens is one of the more significant public health concerns. Moreover, the restrictions on the use of particular antibiotics can limit the options for the treatment of infections in veterinary clinical practice. In this context, searching for alternative antimicrobial substances is crucial nowadays. In this study, 4,4′-dihydroxy-azobenzene (DHAB) was tested for its potential in vitro as an antimicrobial agent against two relevant human and animal pathogens, namely Staphylococcus aureus and Staphylococcus pseudintermedius. The values of minimal inhibitory concentration (MIC) were 64 and 32 mg/L respectively, and they comparable to other azo compounds of probed antimicrobial activity. In addition, the minimal bactericidal concentrations (MCB) were 256 and 64 mg/L. The mechanism by which DHAB produces toxicity in staphylococci has been investigated. DHAB caused membrane damage as revealed by the increase in thiobarbituric acid reactive substances (TBARS) such as malondialdehyde. Furthermore, differential induction of the enzymes peroxidases and superoxide dismutase in S. aureus and S. pseudintermedius suggested their prevalent role in ROS-scavenging due to the oxidative burst induced by this compound in either species. In addition, this substance was able to inhibit the formation of biofilms by both bacteria as observed by colorimetric tests and scanning electron microscopy. In order to assess the relevance of DHAB against clinical strains of MRSA, 10 clinical isolates resistant to either methicillin or daptomycin were assayed; 80% of them gave values of CMI and CMB similar to those of the control S. aureus strain. Finally, cutaneous plasters containing a composite formed by an agar base supplemented with DHAB were designed. These plasters were able to inhibit in vitro the growth of S. aureus and S. pseudintermedius, particularly the later, and this suggests that this substance could be a promising candidat

An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.