30,721 results on '"Abraham, A."'
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2. Multimodal imaging of the role of hyperglycemia after experimental aneurysmal subarachnoid haemorrhage
- Author
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Martín Muñoz, Abraham, Llop Roig, Jordi, Neurociencias, Neurozientziak, Joya Villanúa, Ana Isabel, Martín Muñoz, Abraham, Llop Roig, Jordi, Neurociencias, Neurozientziak, and Joya Villanúa, Ana Isabel
- Abstract
149 p., Esta tesis doctoral se ha centrado en el estudio del efecto de la hiperglicemia en un modelo animal de hemorragia subaracnoidea aneurismática mediante técnicas de tomografía por emisión de positrones (PET) y resonancia magnética (MRI). Se han evaluado diversos aspectos como la aparición de edema e infarto, el volumen de hemorragia, la rotura de la barrera hematoencefálica, la inflamación y el estrés oxidativo. Finalmente, se evaluó el efecto antioxidante del ácido úrico en animales hiperglicémicos con hemorragia subaracnoidea.
- Published
- 2025
3. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
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Schumacher, A, Kyu, H, Aali, A, Abbafati, C, Abbas, J, Abbasgholizadeh, R, Abbasi, M, Abbasian, M, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdoun, M, Abdullahi, A, Abdurehman, A, Abebe, M, Abedi, A, Abegaz, T, Abeldaño Zuñiga, R, Abhilash, E, Abiodun, O, Aboagye, R, Abolhassani, H, Abouzid, M, Abreu, L, Abrha, W, Abrigo, M, Abtahi, D, Abu Rumeileh, S, Abu-Rmeileh, N, Aburuz, S, Abu-Zaid, A, Acuna, J, Adair, T, Addo, I, Adebayo, O, Adegboye, O, Adekanmbi, V, Aden, B, Adepoju, A, Adetunji, C, Adeyeoluwa, T, Adeyomoye, O, Adha, R, Adibi, A, Adikusuma, W, Adnani, Q, Adra, S, Afework, A, Afolabi, A, Afraz, A, Afyouni, S, Afzal, S, Agasthi, P, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, B, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, M, Ahmad, T, Ahmadi, K, Ahmadzade, A, Ahmadzade, M, Ahmed, A, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed, S, Ajami, M, Aji, B, Ajumobi, O, Akalu, G, Akara, E, Akinosoglou, K, Akkala, S, Akyirem, S, Al Hamad, H, Al Hasan, S, Al Homsi, A, Al Qadire, M, Ala, M, Aladelusi, T, AL-Ahdal, T, Alalalmeh, S, Al-Aly, Z, Alam, K, Alam, M, Alam, Z, Al-amer, R, Alanezi, F, Alanzi, T, Albashtawy, M, Albataineh, M, Aldridge, R, Alemi, S, Al-Eyadhy, A, Al-Gheethi, A, Alhabib, K, Alhalaiqa, F, Al-Hanawi, M, Ali, A, Ali, B, Ali, H, Ali, M, Ali, R, Ali, S, Ali, Z, Alian Samakkhah, S, Alicandro, G, Alif, S, Aligol, M, Alimi, R, Aliyi, A, Al-Jumaily, A, Aljunid, S, Almahmeed, W, Al-Marwani, S, Al-Maweri, S, Almazan, J, Al-Mekhlafi, H, Almidani, O, Alomari, M, Alonso, N, Alqahtani, J, Alqutaibi, A, Al-Sabah, S, Altaf, A, Al-Tawfiq, J, Altirkawi, K, Alvi, F, Alwafi, H, Al-Worafi, Y, Aly, H, Alzoubi, K, Amare, A, Ameyaw, E, Amhare, A, Amin, T, Amindarolzarbi, A, Aminian Dehkordi, J, Amiri, S, Amu, H, Amugsi, D, Amzat, J, Ancuceanu, R, Anderlini, D, Andrade, P, Andrei, C, Andrei, T, Angappan, D, Anil, A, Anjum, A, Antony, C, Antriyandarti, E, Anuoluwa, I, Anwar, S, Anyasodor, A, Appiah, S, Aqeel, M, Arabloo, J, Arabzadeh Bahri, R, Arab-Zozani, M, Arafat, M, Araújo, A, Aravkin, A, Aremu, A, Ariffin, H, Aripov, T, Armocida, B, Arooj, M, Artamonov, A, Artanti, K, Arulappan, J, Aruleba, I, Aruleba, R, Arumugam, A, Asaad, M, Asgary, S, Ashemo, M, Ashraf, M, Asika, M, Athari, S, Atout, M, Atreya, A, Attia, S, Aujayeb, A, Avan, A, Awotidebe, A, Ayala Quintanilla, B, Ayanore, M, Ayele, G, Ayuso-Mateos, J, Ayyoubzadeh, S, Azadnajafabad, S, Azhar, G, Aziz, S, Azzam, A, Babashahi, M, Babu, A, Badar, M, Badawi, A, Badiye, A, Baghdadi, S, Bagheri, N, Bagherieh, S, Bah, S, Bahadorikhalili, S, Bai, J, Bai, R, Baker, J, Bakkannavar, S, Bako, A, Balakrishnan, S, Balogun, S, Baltatu, O, Bam, K, Banach, M, Bandyopadhyay, S, Banik, B, Banik, P, Bansal, H, Barati, S, Barchitta, M, Bardhan, M, Barker-Collo, S, Barone-Adesi, F, Barqawi, H, Barr, R, Barrero, L, Basharat, Z, Bashir, A, Bashiru, H, Baskaran, P, Basnyat, B, Bassat, Q, Basso, J, Basu, S, Batra, K, Batra, R, Baune, B, Bayati, M, Bayileyegn, N, Beaney, T, Bedi, N, Begum, T, Behboudi, E, Behnoush, A, Beiranvand, M, Bejarano Ramirez, D, Belgaumi, U, Bell, M, Bello, A, Bello, M, Bello, O, Belo, L, Beloukas, A, Bendak, S, Bennett, D, Bensenor, I, Benzian, H, Berezvai, Z, Berman, A, Bermudez, A, Bettencourt, P, Beyene, H, Beyene, K, Bhagat, D, Bhagavathula, A, Bhala, N, Bhalla, A, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, G, Bhatti, J, Bhatti, M, Bhatti, R, Bhutta, Z, Bikbov, B, Binmadi, N, Bintoro, B, Biondi, A, Bisignano, C, Bisulli, F, Biswas, A, Biswas, R, Bitaraf, S, Bjørge, T, Bleyer, A, Boampong, M, Bodolica, V, Bodunrin, A, Bolarinwa, O, Bonakdar Hashemi, M, Bonny, A, Bora, K, Bora Basara, B, Borodo, S, Borschmann, R, Botero Carvajal, A, Bouaoud, S, Boudalia, S, Boyko, E, Bragazzi, N, Braithwaite, D, Brenner, H, Britton, G, Browne, A, Brunoni, A, Bulamu, N, Bulto, L, Buonsenso, D, Burkart, K, Burns, R, Burugina Nagaraja, S, Busse, R, Bustanji, Y, Butt, Z, Caetano dos Santos, F, Cai, T, Calina, D, Cámera, L, Campos, L, Campos-Nonato, I, Cao, C, Cardenas, C, Cárdenas, R, Carr, S, Carreras, G, Carrero, J, Carugno, A, Carvalho, F, Carvalho, M, Castaldelli-Maia, J, Castañeda-Orjuela, C, Castelpietra, G, Catalá-López, F, Catapano, A, Cattaruzza, M, Caye, A, Cederroth, C, Cembranel, F, Cenderadewi, M, Cercy, K, Cerin, E, Cevik, M, Chacón-Uscamaita, P, Chahine, Y, Chakraborty, C, Chan, J, Chang, C, Charalampous, P, Charan, J, Chattu, V, Chatzimavridou-Grigoriadou, V, Chavula, M, Cheema, H, Chen, A, Chen, H, Chen, L, Chen, M, Chen, S, Cherbuin, N, Chew, D, Chi, G, Chirinos-Caceres, J, Chitheer, A, Cho, S, Cho, W, Chong, B, Chopra, H, Choudhary, R, Chowdhury, R, Chu, D, Chukwu, I, Chung, E, Chung, S, Cini, K, Clark, C, Coberly, K, Columbus, A, Comfort, H, Conde, J, Conti, S, Cortesi, P, Costa, V, Cousin, E, Cowden, R, Criqui, M, Cruz-Martins, N, Culbreth, G, Cullen, P, Cunningham, M, da Silva e Silva, D, Dadana, S, Dadras, O, Dai, Z, Dalal, K, Dalli, L, Damiani, G, D'Amico, E, Daneshvar, S, Darwesh, A, Das, J, Das, S, Dash, N, Dashti, M, Dávila-Cervantes, C, Davis Weaver, N, Davletov, K, De Leo, D, Debele, A, Degenhardt, L, Dehbandi, R, Deitesfeld, L, Delgado-Enciso, I, Delgado-Ortiz, L, Demant, D, Demessa, B, Demetriades, A, Deng, X, Denova-Gutiérrez, E, Deribe, K, Dervenis, N, Des Jarlais, D, Desai, H, Desai, R, Deuba, K, Devanbu, V, Dey, S, Dhali, A, Dhama, K, Dhimal, M, Dhingra, S, Dias da Silva, D, Diaz, D, Dima, A, Ding, D, Dirac, M, Dixit, A, Dixit, S, Do, T, do Prado, C, Dodangeh, M, Dokova, K, Dolecek, C, Dorsey, E, dos Santos, W, Doshi, R, Doshmangir, L, Douiri, A, Dowou, R, Driscoll, T, Dsouza, H, Dube, J, Dumith, S, Dunachie, S, Duncan, B, Duraes, A, Duraisamy, S, Durojaiye, O, Dutta, S, Dzianach, P, Dziedzic, A, Ebenezer, O, Eboreime, E, Ebrahimi, A, Echieh, C, Ed-Dra, A, Edinur, H, Edvardsson, D, Edvardsson, K, Efendi, D, Efendi, F, Eghdami, S, Eikemo, T, Eini, E, Ekholuenetale, M, Ekpor, E, Ekundayo, T, El Arab, R, El Morsi, D, El Sayed Zaki, M, El Tantawi, M, Elbarazi, I, Elemam, N, Elgar, F, Elgendy, I, Elgohary, G, Elhabashy, H, Elhadi, M, Elmeligy, O, Elshaer, M, Elsohaby, I, Emami Zeydi, A, Emamverdi, M, Emeto, T, Engelbert Bain, L, Erkhembayar, R, Eshetie, T, Eskandarieh, S, Espinosa-Montero, J, Estep, K, Etaee, F, Eze, U, Fabin, N, Fadaka, A, Fagbamigbe, A, Fahimi, S, Falzone, L, Farinha, C, Faris, M, Farjoud Kouhanjani, M, Faro, A, Farrokhpour, H, Fatehizadeh, A, Fattahi, H, Fauk, N, Fazeli, P, Feigin, V, Fekadu, G, Fereshtehnejad, S, Feroze, A, Ferrante, D, Ferrara, P, Ferreira, N, Fetensa, G, Filip, I, Fischer, F, Flavel, J, Flaxman, A, Flor, L, Florin, B, Folayan, M, Foley, K, Fomenkov, A, Force, L, Fornari, C, Foroutan, B, Foschi, M, Francis, K, Franklin, R, Freitas, A, Friedman, J, Friedman, S, Fukumoto, T, Fuller, J, Gaal, P, Gadanya, M, Gaihre, S, Gaipov, A, Gakidou, E, Galali, Y, Galehdar, N, Gallus, S, Gan, Q, Gandhi, A, Ganesan, B, Garg, J, Gau, S, Gautam, P, Gautam, R, Gazzelloni, F, Gebregergis, M, Gebrehiwot, M, Gebremariam, T, Gerema, U, Getachew, M, Getachew, T, Gething, P, Ghafourifard, M, Ghahramani, S, Ghailan, K, Ghajar, A, Ghanbarnia, M, Ghasemi, M, Ghasemzadeh, A, Ghassemi, F, Ghazy, R, Ghimire, S, Gholamian, A, Gholamrezanezhad, A, Ghorbani Vajargah, P, Ghozali, G, Ghozy, S, Ghuge, A, Gialluisi, A, Gibson, R, Gil, A, Gill, P, Gill, T, Gillum, R, Ginindza, T, Girmay, A, Glasbey, J, Gnedovskaya, E, Göbölös, L, Goel, A, Goldust, M, Golechha, M, Goleij, P, Golestanfar, A, Golinelli, D, Gona, P, Goudarzi, H, Goudarzian, A, Goyal, A, Greenhalgh, S, Grivna, M, Guarducci, G, Gubari, M, Gudeta, M, Guha, A, Guicciardi, S, Gunawardane, D, Gunturu, S, Guo, C, Gupta, A, Gupta, B, Gupta, I, Gupta, R, Gupta, S, Gupta, V, Gutiérrez, R, Habibzadeh, F, Habibzadeh, P, Hachinski, V, Haddadi, M, Haddadi, R, Haep, N, Hajj Ali, A, Halboub, E, Halim, S, Hall, B, Haller, S, Halwani, R, Hamadeh, R, Hamagharib Abdullah, K, Hamidi, S, Hamiduzzaman, M, Hammoud, A, Hanifi, N, Hankey, G, Hannan, M, Haque, M, Harapan, H, Haro, J, Hasaballah, A, Hasan, F, Hasan, I, Hasan, M, Hasani, H, Hasanian, M, Hasanpour- Dehkordi, A, Hassan, A, Hassanian-Moghaddam, H, Hassanipour, S, Haubold, J, Havmoeller, R, Hay, S, Hbid, Y, Hebert, J, Hegazi, O, Heidari, G, Heidari, M, Heidari-Foroozan, M, Heidari-Soureshjani, R, Helfer, B, Herteliu, C, Hesami, H, Hettiarachchi, D, Heyi, D, Hezam, K, Hiraike, Y, Hoffman, H, Holla, R, Horita, N, Hossain, M, Hossain, S, Hosseini, M, Hosseinzadeh, H, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hsairi, M, Hsieh, V, Hu, C, Huang, J, Huda, M, Hugo, F, Hultström, M, Hussain, J, Hussain, S, Hussein, N, Huy, L, Huynh, H, Hwang, B, Ibitoye, S, Idowu, O, Ijo, D, Ikuta, K, Ilaghi, M, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Inbaraj, L, Iradukunda, A, Iravanpour, F, Iregbu, K, Islam, M, Islam, S, Islami, F, Ismail, N, Isola, G, Iwagami, M, Iwu, C, Iwu-Jaja, C, Iyer, M, J, L, Jaafari, J, Jacob, L, Jacobsen, K, Jadidi-Niaragh, F, Jafarinia, M, Jaggi, K, Jahankhani, K, Jahanmehr, N, Jahrami, H, Jain, A, Jain, N, Jairoun, A, Jakovljevic, M, Jalilzadeh Yengejeh, R, Jamshidi, E, Jani, C, Janko, M, Jatau, A, Jayapal, S, Jayaram, S, Jeganathan, J, Jema, A, Jemere, D, Jeong, W, Jha, A, Jha, R, Ji, J, Jiang, H, Jin, Y, Johnson, O, Jomehzadeh, N, Jones, D, Joo, T, Joseph, A, Joseph, N, Joshua, C, Jozwiak, J, Jürisson, M, Kaambwa, B, Kabir, A, Kabir, H, Kabir, Z, Kadashetti, V, Kahe, F, Kakodkar, P, Kalani, R, Kalankesh, L, Kaliyadan, F, Kalra, S, Kamath, A, Kamireddy, A, Kanagasabai, T, Kandel, H, Kanmiki, E, Kanmodi, K, Kantar, R, Kapoor, N, Karajizadeh, M, Karami Matin, B, Karanth, S, Karaye, I, Karim, A, Karimi, H, Karimi, S, Karimi Behnagh, A, Karkhah, S, Karna, A, Kashoo, F, Kasraei, H, Kassaw, N, Kassebaum, N, Kassel, M, Katamreddy, A, Katikireddi, S, Katoto, P, Kauppila, J, Kaur, N, Kaydi, N, Kayibanda, J, Kayode, G, Kazemi, F, Kazemian, S, Kazeminia, S, Keikavoosi-Arani, L, Keller, C, Kempen, J, Kerr, J, Kesse-Guyot, E, Keykhaei, M, Khadembashiri, M, Khafaie, M, Khajuria, H, Khalafi, M, Khalaji, A, Khalid, N, Khalil, I, Khamesipour, F, Khan, A, Khan, G, Khan, I, Khan, M, Khan, T, Khan suheb, M, Khanmohammadi, S, Khatab, K, Khatami, F, Khavandegar, A, Khayat Kashani, H, Kheirallah, K, Khidri, F, Khodadoust, E, Khormali, M, Khosrowjerdi, M, Khubchandani, J, Khusun, H, Kifle, Z, Kim, G, Kim, J, Kimokoti, R, Kinzel, K, Kiross, G, Kisa, A, Kisa, S, Kiss, J, Kivimäki, M, Klu, D, Knudsen, A, Kolahi, A, Kompani, F, Koren, G, Kosen, S, Kostev, K, Kotnis, A, Koul, P, Koulmane Laxminarayana, S, Koyanagi, A, Kravchenko, M, Krishan, K, Krishna, H, Krishnamoorthy, V, Krishnamoorthy, Y, Krohn, K, Kuate Defo, B, Kubeisy, C, Kucuk Bicer, B, Kuddus, M, Kuitunen, I, Kujan, O, Kulimbet, M, Kulkarni, V, Kumar, A, Kumar, H, Kumar, N, Kumar, R, Kumar, S, Kumari, M, Kurmanova, A, Kurmi, O, Kusnali, A, Kusuma, D, Kutluk, T, Kuttikkattu, A, Kyei, E, Kyriopoulos, I, La Vecchia, C, Ladan, M, Laflamme, L, Lahariya, C, Lahmar, A, Lai, D, Laksono, T, Lal, D, Lalloo, R, Lallukka, T, Lám, J, Lamnisos, D, Lan, T, Lanfranchi, F, Langguth, B, Lansingh, V, Laplante-Lévesque, A, Larijani, B, Larsson, A, Lasrado, S, Latief, K, Latif, M, Latifinaibin, K, Lauriola, P, Le, L, Le, N, Le, T, Lee, M, Lee, P, Lee, S, Lee, W, Lee, Y, Legesse, S, Leigh, J, Lenzi, J, Leong, E, Lerango, T, Li, M, Li, W, Li, X, Li, Y, Li, Z, Libra, M, Ligade, V, Likaka, A, Lim, L, Lin, R, Lin, S, Lioutas, V, Listl, S, Liu, J, Liu, S, Liu, X, Livingstone, K, Llanaj, E, Lo, C, Loreche, A, Lorenzovici, L, Lotfi, M, Lotfizadeh, M, Lozano, R, Lubinda, J, Lucchetti, G, Lugo, A, Lunevicius, R, Ma, J, Ma, S, Ma, Z, Mabrok, M, Machairas, N, Machoy, M, Madsen, C, Magaña Gómez, J, Maghazachi, A, Maharaj, S, Maharjan, P, Mahjoub, S, Mahmoud, M, Mahmoudi, E, Mahmoudi, M, Makram, O, Malagón-Rojas, J, Malakan Rad, E, Malekzadeh, R, Malhotra, A, Malhotra, K, Malik, A, Malik, I, Malinga, L, Malta, D, Mamun, A, Manla, Y, Mannan, F, Mansoori, Y, Mansour, A, Mansouri, V, Mansournia, M, Mantovani, L, Marasini, B, Marateb, H, Maravilla, J, Marconi, A, Mardi, P, Marino, M, Marjani, A, Marrugo Arnedo, C, Martinez-Guerra, B, Martinez-Piedra, R, Martins, C, Martins-Melo, F, Martorell, M, Marx, W, Maryam, S, Marzo, R, Mate, K, Matei, C, Mathioudakis, A, Maude, R, Maugeri, A, May, E, Mayeli, M, Mazaheri, M, Mazidi, M, Mazzotti, A, Mcalinden, C, Mcgrath, J, Mckee, M, Mckowen, A, Mclaughlin, S, Mcphail, M, Mcphail, S, Mechili, E, Mediratta, R, Meena, J, Mehari, M, Mehlman, M, Mehra, R, Mehrabani-Zeinabad, K, Mehrabi Nasab, E, Mehrotra, R, Mekonnen, M, Mendoza, W, Menezes, R, Mengesha, E, Mensah, G, Mensah, L, Mentis, A, Meo, S, Meretoja, A, Meretoja, T, Mersha, A, Mesfin, B, Mestrovic, T, Mhlanga, A, Mhlanga, L, Mi, T, Micha, G, Michalek, I, Miller, T, Mindlin, S, Minelli, G, Minh, L, Mini, G, Minja, N, Mirdamadi, N, Mirghafourvand, M, Mirica, A, Mirinezhad, S, Mirmosayyeb, O, Mirutse, M, Mirza-Aghazadeh-Attari, M, Mirzaei, M, Misgana, T, Misra, S, Mitchell, P, Mithra, P, Mittal, C, Mittal, M, Moazen, B, Mohamed, A, Mohamed, J, Mohamed, M, Mohamed, N, Mohammad-Alizadeh-Charandabi, S, Mohammadi, S, Mohammadian-Hafshejani, A, Mohammad-pour, S, Mohammadshahi, M, Mohammed, M, Mohammed, S, Mojiri-forushani, H, Mokdad, A, Mokhtarzadehazar, P, Momenzadeh, K, Momtazmanesh, S, Monasta, L, Moni, M, Montazeri, F, Moodi Ghalibaf, A, Moradi, M, Moradi, Y, Moradi-Lakeh, M, Moradinazar, M, Moradpour, F, Moraga, P, Morawska, L, Moreira, R, Morovatdar, N, Morrison, S, Morze, J, Mosaddeghi Heris, R, Mosser, J, Mossialos, E, Mostafavi, H, Mostofinejad, A, Mougin, V, Mouodi, S, Mousavi, P, Mousavi, S, Mousavi Khaneghah, A, Mpundu-Kaambwa, C, Mrejen, M, Mubarik, S, Muccioli, L, Mueller, U, Mughal, F, Mukherjee, S, Mukoro, G, Mulita, A, Mulita, F, Muniyandi, M, Munjal, K, Musaigwa, F, Musallam, K, Mustafa, G, Muthu, S, Muthupandian, S, Myung, W, Nabhan, A, Nafukho, F, Nagarajan, A, Naghavi, M, Naghavi, P, Naik, G, Naimzada, M, Nair, S, Nair, T, Najmuldeen, H, Naldi, L, Nangia, V, Nargus, S, 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Yiğit, Vahit, Yip, Paul, Yon, Dong Keon, Yonemoto, Naohiro, You, Yuyi, Younis, Mustafa Z, Yu, Chuanhua, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zahedi, Mohammad, Zahid, Muhammad Nauman, Zahir, Mazyar, Zakham, Fathiah, Zaki, Nazar, Zakzuk, Josefina, Zamagni, Giulia, Zaman, Burhan Abdullah, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zandi, Milad, Zandieh, Ghazal G Z, Zanghì, Aurora, Zare, Iman, Zastrozhin, Mikhail Sergeevich, Zeariya, Mohammed G M, Zeng, Youjie, Zhai, Chunxia, Zhang, Chen, Zhang, Haijun, Zhang, Hongwei, Zhang, Yunquan, Zhang, Zhaofeng, Zhang, Zhenyu, Zhao, Hanqing, Zhao, Yang, Zhao, Yong, Zheng, Peng, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Zhaohua, Ziaeefar, Pardis, Zielińska, Magdalena, Zou, Zhiyong, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Lim, Stephen S, and Murray, Christopher J L
- Published
- 2024
4. Automated Detection of Galactic Rings from SDSS Images
- Author
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Abraham, Linn, Abraham, Sheelu, Kembhavi, Ajit K., Philip, N. S., Aniyan, A. K., Barway, Sudhanshu, Kumar, Harish, Abraham, Linn, Abraham, Sheelu, Kembhavi, Ajit K., Philip, N. S., Aniyan, A. K., Barway, Sudhanshu, and Kumar, Harish
- Abstract
Morphological features in galaxies, like spiral arms, bars, rings, tidal tails etc. carry information about their structure, origin and evolution. It is therefore important to catalogue and study such features and to correlate them with other basic galaxy properties the environment in which the galaxies are located and their interactions with other galaxies. Surveys such as SDSS, Pan-STARRS, HSC-SSP have made available very large samples of galaxies for gainful morphological studies. The availability of galaxy images and catalogues will increase manifold with future surveys like LSST. The volume of present and future data is so large that traditional methods, which involve expert astronomers identifying morphological features through visual inspection, are no longer sufficient. It is therefore necessary to use AI based techniques like machine learning and deep learning for finding morphological structures quickly and efficiently. We report in this study the application of deep learning for finding ring like structures in galaxy images from the Sloan Digital Sky Survey (SDSS) data release DR18. We use a catalogue by Buta (2017) of ringed galaxies from the SDSS to train the network reaching good accuracy and recall, and generate a catalogue of 29420 galaxies of which 9805 have ring like structures with prediction confidence exceeding 90 percent. Using a catalogue of barred galaxy images identified by Abraham et. al. (2018) using deep learning techniques, we identify a set of 2087 galaxies with bars as well as rings. The catalogues should be very useful in understanding the origin of these important morphological structures., Comment: 19 pages, 13 figures, 1 Table. Submitted to ApJ
- Published
- 2024
5. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
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Konstantinos, Nikoobar, Ali, Nikoomanesh, Fatemeh, Nikpoor, Amin Reza, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A, Nnyanzi, Lawrence Achilles, Noman, Efaq Ali, Nomura, Shuhei, Noreen, Mamoona, Noroozi, Nafise, Norrving, Bo, Noubiap, Jean Jacques, Novotney, Amanda, Nri-Ezedi, Chisom Adaobi, Ntaios, George, Ntsekhe, Mpiko, Nuñez-Samudio, Virginia, Nurrika, Dieta, Nutor, Jerry John, Oancea, Bogdan, Obamiro, Kehinde O, Oboh, Mary Aigbiremo, Odetokun, Ismail A, Odogwu, Nkechi Martina, O'Donnell, Martin James, Oduro, Michael Safo, Ofakunrin, Akinyemi O D, Ogunkoya, Abiola, Oguntade, Ayodipupo Sikiru, Oh, In-Hwan, Okati-Aliabad, Hassan, Okeke, Sylvester Reuben, Okekunle, Akinkunmi Paul, Okonji, Osaretin Christabel, Olagunju, Andrew T, Olaiya, Muideen Tunbosun, Olatubi, Matthew Idowu, Oliveira, Gláucia Maria Moraes, Olufadewa, Isaac Iyinoluwa, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwafemi, Yinka Doris, Omar, Hany A, Omar Bali, Ahmed, Omer, Goran Latif, Ondayo, 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Ramin, Ravikumar, Nakul, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawlley, Bharat, Raza, Rabail Zehra, Razo, Christian, Redwan, Elrashdy Moustafa Mohamed, Rehman, Faizan Ur, Reifels, Lennart, Reiner Jr, Robert C, Remuzzi, Giuseppe, Reyes, Luis Felipe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Rhee, Taeho Gregory, Riaz, Mavra A, Ribeiro, Antonio Luiz P, Rickard, Jennifer, Riva, Hannah R, Robinson-Oden, Hannah Elizabeth, Rodrigues, Célia Fortuna, Rodrigues, Mónica, Roever, Leonardo, Rogowski, Emma Lynn Best, Rohloff, Peter, Romadlon, Debby Syahru, Romero-Rodríguez, Esperanza, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rout, Himanshu Sekhar, Roy, Nitai, Roy, Priyanka, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, Rwegerera, Godfrey M, Rynkiewicz, Andrzej, S N, Chandan, Saad, Aly M A, Saadatian, Zahra, Saber, Korosh, Saber-Ayad, Maha Mohamed, SaberiKamarposhti, Morteza, 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Sarikhani, Yaser, Sarkar, Tanmay, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Satpathy, Maheswar, Sayeed, Abu, Sayeed, Md Abu, Saylan, Mete, Sayyah, Mehdi, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schlaich, Markus P, Schlee, Winfried, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Schwendicke, Falk, Šekerija, Mario, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Sethi, Yashendra, Sha, Feng, Shabany, Maryam, Shafaat, Amir, Shafie, Mahan, Shah, Nilay S, Shah, Pritik A, Shah, Syed Mahboob, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Izza, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Ahmed, Shaikh, Masood Ali, Shakeri, Alireza, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Rajesh, Sharma, Saurab, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shi, Peilin, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Min-Jeong, Shin, Youn Ho, Shiri, Rahman, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shokraneh, Farhad, Shokri, Azad, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Shuval, Kerem, Siddig, Emmanuel Edwar, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Garima, Singh, Jasbir, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinto, Robert, Siraj, Md Shahjahan, Sirota, Sarah Brooke, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Socea, Bogdan, Sokhan, Anton, Solanki, Ranjan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stark, Benjamin A, Starnes, Joseph R, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stevanović, Aleksandar, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Haitong Zhe, Sun, Jing, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabish, Mohammad, TADAKAMADLA, JYOTHI, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tang, Hong K, Tarigan, Ingan Ukur, Tariku, Mengistie Kassahun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Rishu, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Thomas, Nikhil Kenny, Thomson, Azalea M, Thrift, Amanda G, Thum, Chern Choong Chern, Thygesen, Lau Caspar, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L
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- 2024
6. On the Round Complexity of Asynchronous Crusader Agreement
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Ittai Abraham and Naama Ben-David and Gilad Stern and Sravya Yandamuri, Abraham, Ittai, Ben-David, Naama, Stern, Gilad, Yandamuri, Sravya, Ittai Abraham and Naama Ben-David and Gilad Stern and Sravya Yandamuri, Abraham, Ittai, Ben-David, Naama, Stern, Gilad, and Yandamuri, Sravya
- Abstract
We present new lower and upper bounds on the number of communication rounds required for asynchronous Crusader Agreement (CA) and Binding Crusader Agreement (BCA), two primitives that are used for solving binary consensus. We show results for the information theoretic and authenticated settings. In doing so, we present a generic model for proving round complexity lower bounds in the asynchronous setting. In some settings, our attempts to prove lower bounds on round complexity fail. Instead, we show new, tight, rather surprising round complexity upper bounds for Byzantine fault tolerant BCA with and without a PKI setup.
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- 2024
- Full Text
- View/download PDF
7. Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries
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Starr, Nichole, Starr, Nichole, Tadesse, Mekdim, Igwebuike, Chinaemere, Sherefa, Kalid, Genetu, Abraham, Aregawi, Yohanna, Zewdu, Ebenezer, Tamirat, Daniel, Desalegn, Migbar, Getahun, Bantie, Harris, Hobart, Zemenfes, Daniel, Starr, Nichole, Starr, Nichole, Tadesse, Mekdim, Igwebuike, Chinaemere, Sherefa, Kalid, Genetu, Abraham, Aregawi, Yohanna, Zewdu, Ebenezer, Tamirat, Daniel, Desalegn, Migbar, Getahun, Bantie, Harris, Hobart, and Zemenfes, Daniel
- Abstract
IntroductionSmall bowel obstruction (SBO) is one of the most common causes for hospital admission in Ethiopia. The use of water-soluble contrast agents (WSCAs) such as Gastrografin to manage adhesive SBO can predict nonoperative resolution of SBO and reduce decision time to surgery and length of hospital stay. However, nothing is known about practice patterns and Gastrografin use in low-income settings. We sought to characterize current management practices, including use of WSCAs, as well as outcomes for patients with SBO in Addis Ababa, Ethiopia.MethodsWe conducted a mixed-methods study consisting of a survey of surgeons throughout Ethiopia and a retrospective record review at five public, tertiary care-level teaching hospitals in Addis Ababa.ResultsOf the 76 surgeons who completed the survey, 63% had heard of the use of WSCAs for SBO and only 11% used oral agents for its management. Chart review of 149 patients admitted with SBO showed the most common etiology was adhesion (39.6% of admissions), followed by small bowel volvulus (20.8%). Most patients (83.2%) underwent surgery during their admission. The most common diagnosis in patients who did not require surgery was also adhesion (68.0%), as well as for those who had surgery (33.9%), followed by small bowel volvulus (24.2%).ConclusionsThe etiology of SBO in Ethiopia may be changing, with postoperative adhesions becoming more common than other historically more prevalent causes. Although a Gastrografin protocol as a diagnostic and potentially therapeutic aid for SBO is feasible in this population and setting, challenges can be anticipated, and future studies of protocol implementation and effectiveness are needed to further inform its utility in Ethiopia and other low-income and middle-income countries.
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- 2024
8. An End-to-End High-performance Deduplication Scheme for Docker Registries and Docker Container Storage Systems
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Zhao, Nannan, Lin, Muhui, Albahar, Hadeel, Paul, Arnab K., Huan, Zhijie, Abraham, Subil, Chen, Keren, Tarasov, Vasily, Skourtis, Dimitrios, Anwar, Ali, Butt, Ali R., Zhao, Nannan, Lin, Muhui, Albahar, Hadeel, Paul, Arnab K., Huan, Zhijie, Abraham, Subil, Chen, Keren, Tarasov, Vasily, Skourtis, Dimitrios, Anwar, Ali, and Butt, Ali R.
- Abstract
The wide adoption of Docker containers for supporting agile and elastic enterprise applications has led to a broad proliferation of container images. The associated storage performance and capacity requirements place high pressure on the infrastructure of container registries that store and distribute images and container storage systems on the Docker client side that manage image layers and store ephemeral data generated at container runtime. The storage demand is worsened by the large amount of duplicate data in images. Moreover, container storage systems that use Copy-on-Write (CoW) file systems as storage drivers exacerbate the redundancy. Exploiting the high file redundancy in real-world images is a promising approach to drastically reduce the growing storage requirements of container registries and improve the space efficiency of container storage systems. However, existing deduplication techniques significantly degrade the performance of both registries and container storage systems because of data reconstruction overhead as well as the deduplication cost. We propose DupHunter, an end-to-end deduplication that deduplicates layers for both Docker registries and container storage systems while maintaining a high image distribution speed and container I/O performance. DupHunter is divided into 3 tiers: Docker registry tier, middle tier, and client tier. Specifically, we first build a high-performance deduplication engine at the Docker registry tier that not only natively deduplicates layers for space savings but also reduces layer restore overhead. Then, we use deduplication offloading at the middle tier that utilizes the deduplication engine to eliminate the redundant files from the client tier, which avoids introducing deduplication overhead to the Docker client side. To further reduce the data duplicates caused by CoW and improve the container I/O performance, we use a container-aware backing file system at the client tier that preallocates space for each con
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- 2024
9. The bii4africa dataset of faunal and floral population intactness estimates across Africa’s major land uses
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Environmental Sciences, Clements, Hayley S., Do Linh San, Emmanuel, Hempson, Gareth, Linden, Birthe, Maritz, Bryan, Monadjem, Ara, Reynolds, Chevonne, Siebert, Frances, Stevens, Nicola, Biggs, Reinette, De Vos, Alta, Blanchard, Ryan, Child, Matthew, Esler, Karen J., Hamann, Maike, Loft, Ty, Reyers, Belinda, Selomane, Odirilwe, Skowno, Andrew L., Tshoke, Tshegofatso, Abdoulaye, Diarrassouba, Aebischer, Thierry, Aguirre-Gutiérrez, Jesús, Alexander, Graham J., Ali, Abdullahi H., Allan, David G., Amoako, Esther E., Angedakin, Samuel, Aruna, Edward, Avenant, Nico L., Badjedjea, Gabriel, Bakayoko, Adama, Bamba-kaya, Abraham, Bates, Michael F., Bates, Paul J. J., Belmain, Steven R., Bennitt, Emily, Bradley, James, Brewster, Chris A., Brown, Michael B., Brown, Michelle, Bryja, Josef, Butynski, Thomas M., Carvalho, Filipe, Channing, Alan, Chapman, Colin A., Cohen, Callan, Cords, Marina, Cramer, Jennifer D., Cronk, Nadine, Cunneyworth, Pamela M. K., Dalerum, Fredrik, Danquah, Emmanuel, Davies-Mostert, Harriet T., de Blocq, Andrew D., De Jong, Yvonne A., Demos, Terrence C., Denys, Christiane, Djagoun, Chabi A. M. S., Doherty-Bone, Thomas M., Drouilly, Marine, du Toit, Johan T., Ehlers Smith, David A., Ehlers Smith, Yvette C., Eiseb, Seth J., Fashing, Peter J., Ferguson, Adam W., Fernández-García, José M., Finckh, Manfred, Fischer, Claude, Gandiwa, Edson, Gaubert, Philippe, Gaugris, Jerome Y., Gibbs, Dalton J., Gilchrist, Jason S., Gil-Sánchez, Jose M., Githitho, Anthony N., Goodman, Peter S., Granjon, Laurent, Grobler, J. Paul, Gumbi, Bonginkosi C., Gvozdik, Vaclav, Harvey, James, Hauptfleisch, Morgan, Hayder, Firas, Hema, Emmanuel M., Herbst, Marna, Houngbédji, Mariano, Huntley, Brian J., Hutterer, Rainer, Ivande, Samuel T., Jackson, Kate, Jongsma, Gregory F. M., Juste, Javier, Kadjo, Blaise, Kaleme, Prince K., Kamugisha, Edwin, Kaplin, Beth A., Kato, Humphrey N., Kiffner, Christian, Kimuyu, Duncan M., Kityo, Robert M., Kouamé, N’goran G., Kouete T, Marcel, le Roux, Aliza, Lee, Alan T. K., Lötter, Mervyn C., Lykke, Anne Mette, MacFadyen, Duncan N., Macharia, Gacheru P., Madikiza, Zimkitha J. K., Mahlaba, Themb’alilahlwa A. M., Mallon, David, Mamba, Mnqobi L., Mande, Claude, Marchant, Rob A., Maritz, Robin A., Markotter, Wanda, McIntyre, Trevor, Measey, John, Mekonnen, Addisu, Meller, Paulina, Melville, Haemish I., Mganga, Kevin Z., Mills, Michael G. L., Minnie, Liaan, Missoup, Alain Didier, Mohammad, Abubakr, Moinde, Nancy N., Moise, Bakwo Fils E., Monterroso, Pedro, Moore, Jennifer F., Musila, Simon, Nago, Sedjro Gilles A., Namoto, Maganizo W., Niang, Fatimata, Nicolas, Violaine, Nkenku, Jerry B., Nkrumah, Evans E., Nono, Gonwouo L., Norbert, Mulavwa M., Nowak, Katarzyna, Obitte, Benneth C., Okoni-Williams, Arnold D., Onongo, Jonathan, O’Riain, M. Justin, Osinubi, Samuel T., Parker, Daniel M., Parrini, Francesca, Peel, Mike J. S., Penner, Johannes, Pietersen, Darren W., Plumptre, Andrew J., Ponsonby, Damian W., Porembski, Stefan, Power, R. John, Radloff, Frans G. T., Rambau, Ramugondo V., Ramesh, Tharmalingam, Richards, Leigh R., Rödel, Mark-Oliver, Rollinson, Dominic P., Rovero, Francesco, Saleh, Mostafa A., Schmiedel, Ute, Schoeman, M. Corrie, Scholte, Paul, Serfass, Thomas L., Shapiro, Julie Teresa, Shema, Sidney, Siebert, Stefan J., Slingsby, Jasper A., Sliwa, Alexander, Smit-Robinson, Hanneline A., Sogbohossou, Etotepe A., Somers, Michael J., Spawls, Stephen, Streicher, Jarryd P., Swanepoel, Lourens, Tanshi, Iroro, Taylor, Peter J., Taylor, William A., te Beest, Mariska, Telfer, Paul T., Thompson, Dave I., Tobi, Elie, Tolley, Krystal A., Turner, Andrew A., Twine, Wayne, Van Cakenberghe, Victor, Van de Perre, Frederik, van der Merwe, Helga, van Niekerk, Chris J. G., van Wyk, Pieter C. V., Venter, Jan A., Verburgt, Luke, Veron, Geraldine, Vetter, Susanne, Vorontsova, Maria S., Wagner, Thomas C., Webala, Paul W., Weber, Natalie, Weier, Sina M., White, Paula A., Whitecross, Melissa A., Wigley, Benjamin J., Willems, Frank J., Winterbach, Christiaan W., Woodhouse, Galena M., Environmental Sciences, Clements, Hayley S., Do Linh San, Emmanuel, Hempson, Gareth, Linden, Birthe, Maritz, Bryan, Monadjem, Ara, Reynolds, Chevonne, Siebert, Frances, Stevens, Nicola, Biggs, Reinette, De Vos, Alta, Blanchard, Ryan, Child, Matthew, Esler, Karen J., Hamann, Maike, Loft, Ty, Reyers, Belinda, Selomane, Odirilwe, Skowno, Andrew L., Tshoke, Tshegofatso, Abdoulaye, Diarrassouba, Aebischer, Thierry, Aguirre-Gutiérrez, Jesús, Alexander, Graham J., Ali, Abdullahi H., Allan, David G., Amoako, Esther E., Angedakin, Samuel, Aruna, Edward, Avenant, Nico L., Badjedjea, Gabriel, Bakayoko, Adama, Bamba-kaya, Abraham, Bates, Michael F., Bates, Paul J. J., Belmain, Steven R., Bennitt, Emily, Bradley, James, Brewster, Chris A., Brown, Michael B., Brown, Michelle, Bryja, Josef, Butynski, Thomas M., Carvalho, Filipe, Channing, Alan, Chapman, Colin A., Cohen, Callan, Cords, Marina, Cramer, Jennifer D., Cronk, Nadine, Cunneyworth, Pamela M. K., Dalerum, Fredrik, Danquah, Emmanuel, Davies-Mostert, Harriet T., de Blocq, Andrew D., De Jong, Yvonne A., Demos, Terrence C., Denys, Christiane, Djagoun, Chabi A. M. S., Doherty-Bone, Thomas M., Drouilly, Marine, du Toit, Johan T., Ehlers Smith, David A., Ehlers Smith, Yvette C., Eiseb, Seth J., Fashing, Peter J., Ferguson, Adam W., Fernández-García, José M., Finckh, Manfred, Fischer, Claude, Gandiwa, Edson, Gaubert, Philippe, Gaugris, Jerome Y., Gibbs, Dalton J., Gilchrist, Jason S., Gil-Sánchez, Jose M., Githitho, Anthony N., Goodman, Peter S., Granjon, Laurent, Grobler, J. Paul, Gumbi, Bonginkosi C., Gvozdik, Vaclav, Harvey, James, Hauptfleisch, Morgan, Hayder, Firas, Hema, Emmanuel M., Herbst, Marna, Houngbédji, Mariano, Huntley, Brian J., Hutterer, Rainer, Ivande, Samuel T., Jackson, Kate, Jongsma, Gregory F. M., Juste, Javier, Kadjo, Blaise, Kaleme, Prince K., Kamugisha, Edwin, Kaplin, Beth A., Kato, Humphrey N., Kiffner, Christian, Kimuyu, Duncan M., Kityo, Robert M., Kouamé, N’goran G., Kouete T, Marcel, le Roux, Aliza, Lee, Alan T. K., Lötter, Mervyn C., Lykke, Anne Mette, MacFadyen, Duncan N., Macharia, Gacheru P., Madikiza, Zimkitha J. K., Mahlaba, Themb’alilahlwa A. M., Mallon, David, Mamba, Mnqobi L., Mande, Claude, Marchant, Rob A., Maritz, Robin A., Markotter, Wanda, McIntyre, Trevor, Measey, John, Mekonnen, Addisu, Meller, Paulina, Melville, Haemish I., Mganga, Kevin Z., Mills, Michael G. L., Minnie, Liaan, Missoup, Alain Didier, Mohammad, Abubakr, Moinde, Nancy N., Moise, Bakwo Fils E., Monterroso, Pedro, Moore, Jennifer F., Musila, Simon, Nago, Sedjro Gilles A., Namoto, Maganizo W., Niang, Fatimata, Nicolas, Violaine, Nkenku, Jerry B., Nkrumah, Evans E., Nono, Gonwouo L., Norbert, Mulavwa M., Nowak, Katarzyna, Obitte, Benneth C., Okoni-Williams, Arnold D., Onongo, Jonathan, O’Riain, M. Justin, Osinubi, Samuel T., Parker, Daniel M., Parrini, Francesca, Peel, Mike J. S., Penner, Johannes, Pietersen, Darren W., Plumptre, Andrew J., Ponsonby, Damian W., Porembski, Stefan, Power, R. John, Radloff, Frans G. T., Rambau, Ramugondo V., Ramesh, Tharmalingam, Richards, Leigh R., Rödel, Mark-Oliver, Rollinson, Dominic P., Rovero, Francesco, Saleh, Mostafa A., Schmiedel, Ute, Schoeman, M. Corrie, Scholte, Paul, Serfass, Thomas L., Shapiro, Julie Teresa, Shema, Sidney, Siebert, Stefan J., Slingsby, Jasper A., Sliwa, Alexander, Smit-Robinson, Hanneline A., Sogbohossou, Etotepe A., Somers, Michael J., Spawls, Stephen, Streicher, Jarryd P., Swanepoel, Lourens, Tanshi, Iroro, Taylor, Peter J., Taylor, William A., te Beest, Mariska, Telfer, Paul T., Thompson, Dave I., Tobi, Elie, Tolley, Krystal A., Turner, Andrew A., Twine, Wayne, Van Cakenberghe, Victor, Van de Perre, Frederik, van der Merwe, Helga, van Niekerk, Chris J. G., van Wyk, Pieter C. V., Venter, Jan A., Verburgt, Luke, Veron, Geraldine, Vetter, Susanne, Vorontsova, Maria S., Wagner, Thomas C., Webala, Paul W., Weber, Natalie, Weier, Sina M., White, Paula A., Whitecross, Melissa A., Wigley, Benjamin J., Willems, Frank J., Winterbach, Christiaan W., and Woodhouse, Galena M.
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- 2024
10. A blueprint for health technology assessment capacity building: lessons learned from Malta
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Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmaceutical Policy and Regulation, Pharmacoepidemiology and Clinical Pharmacology, Abraham, Katharina, Kvamme, Ingelin, Magrin Sammut, Sylvana, de Vries, Simone, Formosa, Tanya, Dupree, Rudy, Corro Ramos, Isaac, Goettsch, Wim, Franken, Margreet, Afd Pharmacoepi & Clinical Pharmacology, PECP - Centre for Pharmaceutical Policy and Regulation, Pharmacoepidemiology and Clinical Pharmacology, Abraham, Katharina, Kvamme, Ingelin, Magrin Sammut, Sylvana, de Vries, Simone, Formosa, Tanya, Dupree, Rudy, Corro Ramos, Isaac, Goettsch, Wim, and Franken, Margreet
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- 2024
11. Impaired health-related quality of life in idiopathic inflammatory myopathies : a cross-sectional analysis from the COVAD-2 e-survey
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Yoshida, Akira, Li, Yuan, Maroufy, Vahed, Kuwana, Masataka, Sazliyana Shaharir, Syahrul, Makol, Ashima, Sen, Parikshit, Lilleker, James B, Agarwal, Vishwesh, Kadam, Esha, Akawatcharangura Goo, Phonpen, Day, Jessica, Milchert, Marcin, Chen, Yi-Ming, Dey, Dzifa, Velikova, Tsvetelina, Saha, Sreoshy, Edgar Gracia-Ramos, Abraham, Parodis, Ioannis, Nikiphorou, Elena, Tan, Ai Lyn, Nune, Arvind, Cavagna, Lorenzo, Toro Gutiérrez, Carlos Enrique, Caballero-Uribe, Carlo Vinicio, Saavedra, Miguel A, Shinjo, Samuel Katsuyuki, Ziade, Nelly, El Kibbi, Lina, Knitza, Johannes, Distler, Oliver, Chinoy, Hector, Agarwal, Vikas, Aggarwal, Rohit, Gupta, Latika, Yoshida, Akira, Li, Yuan, Maroufy, Vahed, Kuwana, Masataka, Sazliyana Shaharir, Syahrul, Makol, Ashima, Sen, Parikshit, Lilleker, James B, Agarwal, Vishwesh, Kadam, Esha, Akawatcharangura Goo, Phonpen, Day, Jessica, Milchert, Marcin, Chen, Yi-Ming, Dey, Dzifa, Velikova, Tsvetelina, Saha, Sreoshy, Edgar Gracia-Ramos, Abraham, Parodis, Ioannis, Nikiphorou, Elena, Tan, Ai Lyn, Nune, Arvind, Cavagna, Lorenzo, Toro Gutiérrez, Carlos Enrique, Caballero-Uribe, Carlo Vinicio, Saavedra, Miguel A, Shinjo, Samuel Katsuyuki, Ziade, Nelly, El Kibbi, Lina, Knitza, Johannes, Distler, Oliver, Chinoy, Hector, Agarwal, Vikas, Aggarwal, Rohit, and Gupta, Latika
- Abstract
OBJECTIVES: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database. METHODS: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis. RESULTS: We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs vs 13 [11-15] non-IIM AIRDs vs 15 [13-17] nrAIDs vs 17 [15-18] controls, P < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs vs 15 (13-17) controls, P < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients. CONCLUSION: Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs., Funding agency:National Institution for Health Research Manchester Biomedical Research Centre NIHR203308
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- 2024
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12. Feasibility and acceptability of home-based self-collection of multiple vaginal swabs in a general population survey in Britain′s fourth National Survey of Sexual Attitudes and Lifestyles-4 (Natsal-4)
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Oeser, Clarissa, Beddows, Simon, Chang, Gwendolyn, Clifton, Soazig, Conolly, Anne, David, Alexandra, Dema, Emily, Field, Nigel, Gibbs, Jo, Hamilton, Rebecca, Light, Rebecca, Mercer, Catherine H., Panwar, Kavita, Roodt, Abraham, Sadler, Katherine, Sonnenberg, Pam, Unemo, Magnus, Oeser, Clarissa, Beddows, Simon, Chang, Gwendolyn, Clifton, Soazig, Conolly, Anne, David, Alexandra, Dema, Emily, Field, Nigel, Gibbs, Jo, Hamilton, Rebecca, Light, Rebecca, Mercer, Catherine H., Panwar, Kavita, Roodt, Abraham, Sadler, Katherine, Sonnenberg, Pam, and Unemo, Magnus
- Abstract
Background: Despite greater sensitivity of vaginal swabs compared to urine for detection of STIs and high acceptability in clinical settings, acceptability and feasibility of home-based self-collected vaginal swabs for research are less certain. We undertook development work to test these attributes for self-collected vaginal swabs for Natsal-4, a probability sample, interviewer-administered, survey of the ritish population aged 16-59 years. Methods: We conducted two pilot studies in 2021-22. After completing an interview, all participants identifying as cisgender women were invited to provide three self-collected vaginal swabs, with procedures for providing samples during or afte rface-to-face interviews or after remote interviews. Samples were posted to the laboratory. Consent was provided with the understanding of non-return of results. Participants declining vaginal swabs were invited to provide urine. Interviewers were not clinically trained. Qualitative follow-up interviews were conducted with participants and interviewers provided feedback. Results: Of the 153 cisgender women interviewed, 77 (50%) agreed to provide a vaginal swab, and 22 preferred to provide urine, resulting in an overall biosample consent rate of 65%. Of these, 60 swabs and 18 urine samples were received (Figure), resulting in an overall response of 51% (39% for vaginal swabs). Of the 77 who consented to provide swabs, 43 (56%) were during face-to-face interviews, of which 95% were received, compared to 13 (17%) agreeing to collection after face-to-face with 54% received, and 21 (27%) choosing remote interviews with 57% received. Fourteen participants (10 provided swabs) gave follow-up interviews and seven interviewers provided feedback. Participants conveyed their motivation to support research by giving samples. Interviewers were surprised at participants’ willingness to provide swabs. Reasons for not providing a swab included the belief that it was uncomfortable, too intimate or not relev
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- 2024
13. Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay
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Behnisch, Peter, Besselink, Harrie, Suzuki, Go, Buchinger, Sebastian, Reifferscheid, Georg, Lukas, Marcus, Wollenweber, Marc, Wollenweber, Simone, Hollert, Henner, Kunisue, Tatsuya, Tue, Nguyen Minh, Alijagic, Andi, Larsson, Maria, Engwall, Magnus, Ohno, Kayo, Brouwer, Abraham, Behnisch, Peter, Besselink, Harrie, Suzuki, Go, Buchinger, Sebastian, Reifferscheid, Georg, Lukas, Marcus, Wollenweber, Marc, Wollenweber, Simone, Hollert, Henner, Kunisue, Tatsuya, Tue, Nguyen Minh, Alijagic, Andi, Larsson, Maria, Engwall, Magnus, Ohno, Kayo, and Brouwer, Abraham
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Aquatic animals and consumers of aquatic animals are exposed to increasingly complex mixtures of known and as-yet-unknown chemicals with dioxin-like toxicities in the water cycle. Effect- and cell-based bioanalysis can cover known and yet unknown dioxin and dioxin-like compounds as well as complex mixtures thereof but need to be standardized and integrated into international guidelines for environmental testing. In an international laboratory testing (ILT) following ISO/CD 24295 as standard procedure for rat cell-based DR CALUX un-spiked and spiked extracts of drinking-, surface-, and wastewater were validated to generate precision data for the development of the full ISO-standard. We found acceptable repeatability and reproducibility ranges below 36 % by DR CALUX bioassay for the tested un-spiked and spiked water of different origins. The presence of 17 PCDD/Fs and 12 dioxin-like PCBs was also confirmed by congener-specific GC-HRMS analysis. We compared the sum of dioxin-like activity levels measured by DR CALUX bioassay (expressed in 2,3,7,8-TCDD Bioanalytical Equivalents, BEQ; ISO 23196, 2022) with the obtained GC-HRMS chemical analysis results converted to toxic equivalents (TEQ; van den Berg et al., 2013).
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- 2024
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14. Annotated type catalogue of Orthalicoidea (Mollusca, Gastropoda) in the Natural History Museum, London: A supplement
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Ablett, Jonathan D., Breure, A.S.H. (Abraham), Ablett, Jonathan D., and Breure, A.S.H. (Abraham)
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Recently a number of previously unrecognised type specimens representing 8 taxa were found in the general collection of the Natural History Museum, belonging to the Orthalicoidea. We have documented this material in this publication, as a supplement to previous papers published in 2011, 2012, 2014 and 2015. A corrected taxon index to all publications in this series is also part of this paper.
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- 2024
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15. Prediction Window Selection in FCS-MPC for Two-level VSI Applications
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Zafra, Eduardo, Vazquez, Sergio, Dragicevic, Tomislav, Alcaide, Abraham M., Leon, Jose I., Franquelo, Leopoldo G., Zafra, Eduardo, Vazquez, Sergio, Dragicevic, Tomislav, Alcaide, Abraham M., Leon, Jose I., and Franquelo, Leopoldo G.
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Semiconductors in power converters are operated in switched-mode. For a given sampling frequency, a digital controller computes the next actuation according to several objectives. Typically one desires to regulate current or voltage values with minimal error and harmonic distortion. Higher switching frequency of the semiconductor is helpful as the granularity of the problem is improved and the harmonic spectrum is shifted towards high-order harmonics that are easier to filter with passive elements. However, the switching losses increase. Finite control set model predictive control (FCS-MPC) is proven to be an excellent control method with a great ability to maximize harmonic quality in terms of the switching frequency, particularly when the controller is configured to consider long prediction horizons. Nonetheless, in order to avoid computational overruns, the prediction horizon and the sampling frequency cannot be indefinitely increased. In this paper, the trade-off between these two parameters is studied, providing guidelines on FCS-MPC tuning for different configurations.
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- 2024
16. Microstructure development in a case-carburized bearing steel
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Abraham Mathews, J. (author) and Abraham Mathews, J. (author)
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WIND turbines play a crucial role in the global transition towards a sustainable energy future. Maximizing energy production and ensuring a reliable operation is essential to harnessing the full potential of wind energy. Among the critical components, the main shaft bearings have for several years been a focal point due to their significant downtime. In this context, a tribochemical treatment called case-carburization has gained notable attention for enhancing the microstructure of these bearings, to improve their reliability. Case-carburization is a surface treatment technique capable of modifying steel to exhibit a combination of properties such as high fatigue strength, toughness, and wear resistance, that are essential for these bearings as they operate in high-load-bearing environments. In a multi-stage heat treatment process involving case-carburization as the initial stage, the microstructure development at each stage is affected by the final microstructure of the preceding stage. Therefore, a comprehensive understanding of the microstructure at every stage is crucial for assessing its impact on the final microstructure and its properties. This Ph.D. research investigates the microstructure evolution throughout a four-stage heat treatment: carburization, sub-critical isothermal treatment, hardening, and tempering. The second stage is where the sole difference lies with regard to the heat treatment parameters, and is performed along two different routes, also in industrial practise, called the "bainitic route" and "pearlitic route". One of the primary goals of this research is to understand the microstructure development during the different stages of the two heat treatment routes and to provide an understanding of the microstructural features that can potentially affect the properties/performance of bearings. Additionally, this research also aims to identify the specific stage at which these features form and to provide insight into their formation mechanisms, Team Maria Santofimia Navarro
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- 2024
17. Eficacia de la lipoinfiltración de células estromales para el cierre de fístulas perianales refractarias dentro del Hospital Universitario UANL
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Alarcón Sandoval, Abraham Alexander and Alarcón Sandoval, Abraham Alexander
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Introducción: Las patologías anorrectales abarcan diversas condiciones congénitas o adquiridas, entre ellas se encuentran las fístulas anales, la anatomía y la complejidad de las fístulas son fundamentales para su tratamiento. La fístula anorrectal es una patología común que puede derivarse de abscesos anales. En México, la prevalencia es significativa y puede causar síntomas dolorosos y requerir tratamiento quirúrgico. Pueden afectar negativamente la calidad de vida y pueden tener complicaciones graves, incluida la incontinencia fecal y el riesgo de cambios neoplásicos malignos. Es esencial investigar nuevas opciones terapéuticas para mejorar los resultados clínicos y la calidad de vida de los pacientes. Metodología: Estudio prospectivo, analítico y experimental en pacientes con fístulas anales complejas refractarias en el Hospital Universitario “Dr. José Eleuterio González” con seguimiento clínico y fotográfico. Resultados: Se observó una tasa de éxito del 100% en el cierre de fístulas, sin complicaciones asociadas al procedimiento, respaldando la seguridad y eficacia del tratamiento. Discusión: La dermoinyección de células estromales derivadas de adipocitos se muestra como un método efectivo y seguro para el tratamiento de fístulas perianales complejas refractarias, con un alto índice de éxito y sin complicaciones significativas. Este enfoque podría considerarse como una opción viable en el tratamiento de pacientes con fístulas anales resistentes a terapias convencionales.
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- 2024
18. Eficacia de la lipoinfiltración de células estromales para el cierre de fístulas perianales refractarias dentro del Hospital Universitario UANL
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Alarcón Sandoval, Abraham Alexander and Alarcón Sandoval, Abraham Alexander
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Introducción: Las patologías anorrectales abarcan diversas condiciones congénitas o adquiridas, entre ellas se encuentran las fístulas anales, la anatomía y la complejidad de las fístulas son fundamentales para su tratamiento. La fístula anorrectal es una patología común que puede derivarse de abscesos anales. En México, la prevalencia es significativa y puede causar síntomas dolorosos y requerir tratamiento quirúrgico. Pueden afectar negativamente la calidad de vida y pueden tener complicaciones graves, incluida la incontinencia fecal y el riesgo de cambios neoplásicos malignos. Es esencial investigar nuevas opciones terapéuticas para mejorar los resultados clínicos y la calidad de vida de los pacientes. Metodología: Estudio prospectivo, analítico y experimental en pacientes con fístulas anales complejas refractarias en el Hospital Universitario “Dr. José Eleuterio González” con seguimiento clínico y fotográfico. Resultados: Se observó una tasa de éxito del 100% en el cierre de fístulas, sin complicaciones asociadas al procedimiento, respaldando la seguridad y eficacia del tratamiento. Discusión: La dermoinyección de células estromales derivadas de adipocitos se muestra como un método efectivo y seguro para el tratamiento de fístulas perianales complejas refractarias, con un alto índice de éxito y sin complicaciones significativas. Este enfoque podría considerarse como una opción viable en el tratamiento de pacientes con fístulas anales resistentes a terapias convencionales.
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- 2024
19. The quality control programme for ITk strip tracker module assembly
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Tishelman-Charny, Abraham and Tishelman-Charny, Abraham
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The assembly of the ATLAS Inner Tracker requires the construction of 19,000 silicon strip sensor detector modules in eight different geometries. Modules will be assembled and tested at 31 institutes on four continents from sensors, readout chips, and flexes. In order to adhere to the module specifications defined for sufficient tracking performance, a rigorous programme of quality control (QC) was established to cover components at every stage of assembly. This contribution presents an overview of the QC programme for ITk strip tracker modules, issues encountered during the pre-production phase (5% of the production volume), and their solutions.
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- 2024
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20. Long-Distance Signal Propagation in AC-LGAD
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Bishop, Casey, Das, Ayan, Ding, Jane, Gignac, Matthew, Martinez-McKinney, Forest, Mazza, Simone M., Molnar, Adam, Nagel, Noah, Nizam, Mohammad, Ott, Jennifer, Sadrozinski, Hartmut F. -W., Schumm, Bruce, Seiden, Abraham, Shin, Taylor, Summerell, Andrew, Wilder, Max, Zhao, Yuzhan, Bishop, Casey, Das, Ayan, Ding, Jane, Gignac, Matthew, Martinez-McKinney, Forest, Mazza, Simone M., Molnar, Adam, Nagel, Noah, Nizam, Mohammad, Ott, Jennifer, Sadrozinski, Hartmut F. -W., Schumm, Bruce, Seiden, Abraham, Shin, Taylor, Summerell, Andrew, Wilder, Max, and Zhao, Yuzhan
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We investigate the signal propagation in AC-LGAD (aka RSD), which are LGAD with a common N+ layer and segmented AC-coupled readout contacts, by measuring response to IR laser TCT on a large selection of AC-LGAD with strip readout. The interest for this topic derives from the realization that while large charge sharing between neighboring strips is essential for good position resolution, large sharing beyond the next neighbor generates background signals which in general are detrimental to the sensor goal of low occupancy. Using AC-LGAD with strip readout produced by Hamamatsu Photonics (HPK), we evaluate the effects of a variety of sensor properties, including geometrical parameters (strip length, width), process parameters like the N+ layer resistivity, the coupling capacitance, and the thickness of the bulk on the signal sharing and the position resolution., Comment: 9 pages, 7 figures, 13th Hiroshima Symposium HSTD13
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- 2024
21. Benefits of a digital health technology for older nursing home residents.:A de-novo cost-effectiveness model for digital health technologies to aid in the assessment of toileting and containment care needs
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Abraham, Katharina, Kanters, Tim Andre, Wagg, Adrian Stuart, Huige, Nicole, Hutt, Edward, Al, Maiwenn Johanna, Abraham, Katharina, Kanters, Tim Andre, Wagg, Adrian Stuart, Huige, Nicole, Hutt, Edward, and Al, Maiwenn Johanna
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The aim of this study was first, to introduce a comprehensive, de-novo health economic (HE) model incorporating the full range of activities involved in toileting and containment care (T&CC) for people with incontinence, capturing all the potential benefits and costs of existing and future Digital Health Technologies (DHT) aimed at improving continence care, for both residential care and home care. Second, to use this novel model to evaluate the cost-effectiveness of the DHT TENA SmartCare Identifi in the implementation of person-centred continence care (PCCC), compared with conventional continence care for Canadian nursing home residents. The de-novo HE model was designed to evaluate technologies across different care settings from the perspective of several stakeholders. Health states were based on six care need profiles with increasing need for toileting assistance, three care stages with varying degrees of toileting success, and five levels of skin health. The main outcomes were incremental costs and quality-adjusted life years. The effectiveness of the TENA SmartCare Identifi was based primarily on trial data combined with literature and expert opinion where necessary. Costs were reported in CAD 2020. After 2 years, 21% of residents in the DHT group received mainly toileting as their continence care strategy compared with 12% in the conventional care group. Conversely, with the DHT 15% of residents rely mainly on absorbent products for incontinence care, compared with 40% with conventional care. On average, residents lived for 2.34 years, during which the DHT resulted in a small gain in quality-adjusted life years of 0.015 and overall cost-savings of $1,467 per resident compared with conventional care. Most cost-savings were achieved through reduced costs for absorbent products. Since most, if not all, stakeholders gain from use of the DHT-assisted PCCC, widespread use in Canadian residential care facilities should be considered, and similar assessments
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- 2024
22. Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy:SEQUOIA-HCM Baseline Characteristics and Study Design
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Coats, Caroline J., Maron, Martin S., Abraham, Theodore P., Olivotto, Iacopo, Lee, Matthew M.Y., Arad, Michael, Cardim, Nuno, Ma, Chang Sheng, Choudhury, Lubna, Düngen, Hans Dirk, Garcia-Pavia, Pablo, Hagège, Albert A., Lewis, Gregory D., Michels, Michelle, Oreziak, Artur, Owens, Anjali T., Tfelt-Hansen, Jacob, Veselka, Josef, Watkins, Hugh C., Heitner, Stephen B., Jacoby, Daniel L., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, Masri, Ahmad, Coats, Caroline J., Maron, Martin S., Abraham, Theodore P., Olivotto, Iacopo, Lee, Matthew M.Y., Arad, Michael, Cardim, Nuno, Ma, Chang Sheng, Choudhury, Lubna, Düngen, Hans Dirk, Garcia-Pavia, Pablo, Hagège, Albert A., Lewis, Gregory D., Michels, Michelle, Oreziak, Artur, Owens, Anjali T., Tfelt-Hansen, Jacob, Veselka, Josef, Watkins, Hugh C., Heitner, Stephen B., Jacoby, Daniel L., Kupfer, Stuart, Malik, Fady I., Meng, Lisa, Wohltman, Amy, and Masri, Ahmad
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Patients with obstructive hypertrophic cardiomyopathy (oHCM) have increased risk of arrhythmia, stroke, heart failure, and sudden death. Contemporary management of oHCM has decreased annual hospitalization and mortality rates, yet patients have worsening health-related quality of life due to impaired exercise capacity and persistent residual symptoms. Here we consider the design of clinical trials evaluating potential oHCM therapies in the context of SEQUOIA-HCM (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM). This large, phase 3 trial is now fully enrolled (N = 282). Baseline characteristics reflect an ethnically diverse population with characteristics typical of patients encountered clinically with substantial functional and symptom burden. The study will assess the effect of aficamten vs placebo, in addition to standard-of-care medications, on functional capacity and symptoms over 24 weeks. Future clinical trials could model the approach in SEQUOIA-HCM to evaluate the effect of potential therapies on the burden of oHCM. (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM [SEQUOIA-HCM]; NCT05186818).
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- 2024
23. Chemistry-albedo feedbacks offset up to a third of forestation’s CO 2 removal benefits
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Weber, J., King, J.A., Abraham, N.L., Grosvenor, D.P., Smith, C., Shin, Y.M., Lawrence, P., Roe, S., Beerling, D.J., Martin, M.V., Weber, J., King, J.A., Abraham, N.L., Grosvenor, D.P., Smith, C., Shin, Y.M., Lawrence, P., Roe, S., Beerling, D.J., and Martin, M.V.
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- 2024
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24. Chemistry-albedo feedbacks offset up to a third of forestation’s CO 2 removal benefits
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Weber, J., King, J.A., Abraham, N.L., Grosvenor, D.P., Smith, C., Shin, Y.M., Lawrence, P., Roe, S., Beerling, D.J., Martin, M.V., Weber, J., King, J.A., Abraham, N.L., Grosvenor, D.P., Smith, C., Shin, Y.M., Lawrence, P., Roe, S., Beerling, D.J., and Martin, M.V.
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- 2024
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25. Mathematics mobile learning using Google clasroom
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Likotsi, Motebang Abraham and Likotsi, Motebang Abraham
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For many years, the academic performance of learners in Mathematics has raised concerns in Lesotho. Several factors have contributed to this subpar performance, including the absence of school libraries and insufficient teaching and learning resources, notably textbooks. The demand for rented textbooks through the school supply unit has consistently exceeded availability. This research study aimed to achieve two primary objectives: (a) to investigate the impact of mobile learning on learners' performance in Mathematics, and (b) to examine learners' perceptions of Mathematics mobile learning. Utilising a quasi-experimental design, the study employed purposive sampling to select 70 learners. Two secondary schools were randomly assigned as control and experimental groups. A pre-test was administered to both groups as an initial assessment. Subsequently, the experimental group's teachers and learners received training on how to utilise Google Classroom for the distribution and receipt of various learning resources, including Mathematics tutorial videos, online quizzes, practice questions with solutions, and the facilitation of discussions, all accessible via mobile devices. Following four weeks of intervention, a post-test was administered to both the experimental and control groups. Additionally, the experimental group completed a questionnaire. The analysis employed SPSS version 20 for assessing learners' perceptions, while both independent samples t-tests and paired samples t-tests were employed to analyse the test scores. The study revealed a statistically significant improvement in learners' performance within the experimental group (p-value = 0.000038 at a 0.05 significance level) as a result of mobile learning. Furthermore, the research established that learners held positive perceptions and attitudes towards mobile learning, expressing an intention to continue using Mathematics mobile learning in the future. These findings underscore the importance of stakeholde, National Manpower Development Secretariat
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- 2024
26. COVID-19 breakthrough infections in type 1 diabetes mellitus : a cross-sectional study by the COVID-19 Vaccination in Autoimmune Diseases (COVAD) Group
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Panchawagh, Suhrud, Ravichandran, Naveen, Barman, Bhupen, Nune, Arvind, Javaid, Mahnoor, Gracia-Ramos, Abraham Edgar, Day, Jessica, Joshi, Mrudula, Kuwana, Masataka, Saha, Sreoshy, Pande, Arunkumar R., Caballero-Uribe, Carlo Vinicio, Velikova, Tsvetelina, Parodis, Ioannis, Knitza, Johannes, Kadam, Esha, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Boro, Hiya, Aggarwal, Rohit, Agarwal, Vikas, Chatterjee, Tulika, Gupta, Latika, Panchawagh, Suhrud, Ravichandran, Naveen, Barman, Bhupen, Nune, Arvind, Javaid, Mahnoor, Gracia-Ramos, Abraham Edgar, Day, Jessica, Joshi, Mrudula, Kuwana, Masataka, Saha, Sreoshy, Pande, Arunkumar R., Caballero-Uribe, Carlo Vinicio, Velikova, Tsvetelina, Parodis, Ioannis, Knitza, Johannes, Kadam, Esha, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Boro, Hiya, Aggarwal, Rohit, Agarwal, Vikas, Chatterjee, Tulika, and Gupta, Latika
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To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated cohort, 16 (16%) T1DM patients had one BI and 2 (2%) had two BIs. No morbidities or deaths were reported, except for one patient who required hospitalization with oxygen without admission to intensive care. The frequency, clinical features, and severity of BIs were not significantly different between T1DM patients and HCs after adjustment for confounding factors. Our study did not show any statistically significant differences in the frequency, symptoms, duration, or critical care requirements between T1DM and HCs after COVID-19 vaccination. Further research is needed to identify factors associated with inadequate vaccine response in patients with BIs, especially in patients with autoimmune diseases.
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- 2024
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27. Customers driving a firm's responsible innovation response for grand challenges : A co-active issue-selling perspective
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Degbey, William Y., Pelto, Elina, Öberg, Christina, Carmeli, Abraham, Degbey, William Y., Pelto, Elina, Öberg, Christina, and Carmeli, Abraham
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Grand challenges vary across industries and call for firms to craft a responsible innovation response to effectively address them. However, key questions concerning why firms embrace responsible innovation and the process by which they respond to grand challenges have yet to be fully answered. We integrate an issue-selling theoretical lens and the customer role from an innovation perspective to theorize about the different influencing motives that customers exert on their corresponding supplying firm to craft a more responsible innovation response to grand challenges. Based on qualitative data collected in almost a 10-year period from multiple respondents across eight customer firms and two supplying firms, we identify three core motives-regulatory, business opportunity, and socio-environmental motives-that propel customers to influence supplying firms to craft different forms of responsible innovation responses. Our research also reveals three vital socio-human capital pathways-human capital, socio-behavioral, and relationship-which, in turn, foster a co-active engagement in addressing grand challenges innovatively and responsibly. In so doing, this research advances novel theorizing on co-active engagement in responsible innovation where the customer acts as the primary champion and the supplier as the implementer. We discuss the important implications for customers and other stakeholders.
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- 2024
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28. Liver Cirrhosis of Unknown Etiology and Its Predictors in Eastern Ethiopia
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Mekuria,Abraham, Nedi,Teshome, Gong,Yun, Abula,Teferra, Engidawork,Ephrem, Mekuria,Abraham, Nedi,Teshome, Gong,Yun, Abula,Teferra, and Engidawork,Ephrem
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Abraham Nigussie Mekuria,1 Teshome Nedi,1 Yun Yun Gong,2 Teferra Abula,1 Ephrem Engidawork1 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2School of Food Science and Nutrition, University of Leeds, Leeds, UKCorrespondence: Ephrem Engidawork; Teferra Abula, Email ephrem.engidawork@aau.edu.et; abula_teferra@yahoo.comBackground: The global burden of liver cirrhosis is increasing, with 2.1 million incident cases and nearly 1.5 million deaths in 2019. Despite the enormous progress in our understanding of the etiology of liver cirrhosis, significant cases of the disease have been reported in Eastern Ethiopia due to unidentified causes. Hence, this study aimed to identify predictors of liver cirrhosis of unknown etiology in Eastern Ethiopia.Methods: A score of 7 out of 11 possible points on the ultrasound-based cirrhosis scale was used as a diagnostic criterion to include 127 liver cirrhosis patients. The study participantsâ demographic, dietary, lifestyle, and clinical data were gathered using a structured questionnaire and standardized reporting forms. The associations between the outcome (known and unknown etiology) and independent variables were modeled using binary logistic regression analysis.Results: The etiology of liver cirrhosis was known in only 23% of patients and attributed to hepatitis B virus (21%), hepatitis C virus (0.8%), and alcohol abuse (0.8%). Sorghum consumption as a staple food (adjusted odds ratio (AOR) =3.8; 95% CI: 1.2, 12.5), splenomegaly (AOR = 4.0; 95% CI: 1.1, 14.4), and a family history of liver disease (AOR = 0.24; 95% CI: 0.06, 0.91) were significantly associated with liver cirrhosis of unknown etiology.Conclusion: Sorghum consumption was found to be the determinant factor of liver cirrhosis of unknown etiology, suggesting it as a possible source of exposure to aflatoxin B1.Keywords: liver cirrhosis, unknown etiology, sorghum, splenomegaly
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- 2024
29. Evaluation of Red Blood Cell Indices for Prediction of Glycemic Control in People Living with Type 2 Diabetes
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Meshesha,Meiraf, Melke,Ayantu, Ajema,Abraham, Mayisso,Kaleb, Meshesha,Meiraf, Melke,Ayantu, Ajema,Abraham, and Mayisso,Kaleb
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Meiraf Daniel Meshesha,1 Ayantu Melke,2 Abraham Teka Ajema,2 Kaleb Mayisso3 1Department of Internal Medicine, Dilla University, Dilla, Ethiopia; 2Department of Epidemiology, Hawassa University, Hawassa, Ethiopia; 3Department of Public Health, Hawassa University, Hawassa, EthiopiaCorrespondence: Meiraf Daniel Meshesha, Tel +251 096 089 0307, Email meirafdanielm@gmail.comBackground: Achieving target glycemic control in people living with diabetes lessens most of the diabetes-related complications and hemoglobin A1C is the gold standard test for assessing the long-term glycemic control. However, the expensive cost, and its limited access are problematic for routine use in developing countries, demanding an urgent alternative solution. Hence, this study aimed to assess the potential of red blood cell indices in predicting glycemic control among people living with type 2 diabetes at Dilla University Hospital.Methods: A cross-sectional study was conducted among 207 participants with type 2 diabetes. Red blood cell indices were compared between the poor and good glycemic control groups using the t-test. Performance of red cell indices in discriminating poor glycemic control was assessed using receiver operating characteristic analysis.Results: The prevalence of poor glycemic control among the participants was 91.8%. Higher mean hemoglobin (p=0.002) and mean corpuscular hemoglobin (p=0.015) was found in the good glycemic control group. An inverse correlation was also observed between hemoglobin A1C and mean corpuscular hemoglobin (r=â 0.158; P=0.023). The area under the curve to discriminate poor glycemic control from good was statistically significant for hemoglobin, hematocrit, and mean corpuscular hemoglobin. However, hemoglobin had the highest discrimination ability at a cutoff ⤠14.8 g/dL; area under the curve was 0.738 (P=0.001), sensitivity, specificity, and positive predictive value were 68.95%, 82.35%, and 97.77%, respectively.Conclusion: This study revealed th
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- 2024
30. Pilsbrylia, a dextral-shelled door snail from South America (Gastropoda, Clausiliidae)
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Salvador, Rodrigo B., Breure, A.S.H. (Abraham), Salvador, Rodrigo B., and Breure, A.S.H. (Abraham)
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The land snail genus Pilsbrylia Hylton Scott, 1952 has been recently shown to not belong to the superfamily to which it was originally assigned (i.e., the Orthalicoidea), instead pointing out a relationship with the Clausilioidea. In this study, we included the type species of the genus in a multi-marker molecular phylogenetic framework to reassess its family-level classification. Our results show that Pilsbrylia belongs to family Clausiliidae (known as ‘door snails’) and more specifically, to subfamily Peruiniinae. This family is unique among stylommatophorans for consisting almost exclusively of animals with sinistral (left-handed) shells, whilst Pilsbrylia has a “typical” dextral shell.
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- 2024
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31. Global disparities in the treatment of idiopathic inflammatory myopathies : results from an international online survey study
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Ziade, Nelly, Aoude, Marc, Hmamouchi, Ihsane, Naveen, R., Lilleker, James B., Sen, Parikshit, Joshi, Mrudula, Agarwal, Vishwesh, Kardes, Sinan, Day, Jessica, Makol, Ashima, Milchert, Marcin, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina, Edgar Gracia-Ramos, Abraham, Parodis, Ioannis, Nikiphorou, Elena, Chatterjee, Tulika, Tan, Ai Lyn, Saavedra, Miguel A., Shinjo, Samuel Katsuyuki, Knitza, Johannes, Kuwana, Masataka, Nune, Arvind, Cavagna, Lorenzo, Distler, Oliver, Chinoy, Hector, Agarwal, Vikas, Aggarwal, Rohit, Gupta, Latika, Ziade, Nelly, Aoude, Marc, Hmamouchi, Ihsane, Naveen, R., Lilleker, James B., Sen, Parikshit, Joshi, Mrudula, Agarwal, Vishwesh, Kardes, Sinan, Day, Jessica, Makol, Ashima, Milchert, Marcin, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina, Edgar Gracia-Ramos, Abraham, Parodis, Ioannis, Nikiphorou, Elena, Chatterjee, Tulika, Tan, Ai Lyn, Saavedra, Miguel A., Shinjo, Samuel Katsuyuki, Knitza, Johannes, Kuwana, Masataka, Nune, Arvind, Cavagna, Lorenzo, Distler, Oliver, Chinoy, Hector, Agarwal, Vikas, Aggarwal, Rohit, and Gupta, Latika
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OBJECTIVES: We aimed to explore current practice and interregional differences in the treatment of idiopathic inflammatory myopathies (IIMs). We triangulated these observations considering countries' Gross National Income (GNI), disease subtypes, and symptoms using patient-reported information. METHODS: A cross-sectional ancillary analysis of the "COVID-19 vaccination in auto-immune disease" (COVAD) e-survey containing demographic characteristics, IIM subtypes (dermatomyositis (DM), polymyositis (PM), inclusion-body myositis (IBM), anti-synthetase syndrome (ASSD), immune-mediated necrotizing myopathy (IMNM), overlap myopathies (OM)), current symptoms (surrogate for organ involvement), and treatments (corticosteroids (CS), immunomodulators (IM), i.e., antimalarials, immunosuppressants (IS), intravenous immunoglobulins (IVIG), biological treatments, and targeted-synthetic small molecules). Treatments were presented descriptively according to continents, GNI, IIM, and organ involvement, and associated factors were analyzed using multivariable binary logistic regressions. RESULTS: Of 18,851 respondents from 94 countries, 1,418 with IIM were analyzed (age 61 years, 62.5% females). DM (32.4%), IBM (24.5%), and OM (15.8%) were the most common subtypes. Treatment categories included IS (49.4%), CS (38.5%), IM (13.8%), and IVIG (9.4%). Notably, treatments varied across regions, GNI categories (IS mostly used in higher-middle income, IM in lower-middle income, IVIG and biologics largely limited to high-income countries), IIM subtypes (IS and CS associated with ASSD, IM with OM and DM, IVIG with IMNM, and biological treatments with OM and ASSD) and disease manifestations (IS and CS with dyspnea). Most inter-regional treatment disparities persisted after multivariable analysis. CONCLUSION: We identified marked regional treatment disparities in a global cohort of IIM. These observations highlight the need for international consensus-driven management guidelines considering patie, Funding agency:National Institution for Health Research Manchester Biomedical Research Centre Funding Scheme
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- 2024
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32. Type 1 diabetes, COVID-19 vaccines and short-term safety : Subgroup analysis from the global COVAD study
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Chatterjee, Tulika, Ravichandran, Naveen, Nair, Narmadha, Gracia-Ramos, Abraham Edgar, Barman, Bhupen, Sen, Parikshit, Joshi, Mrudula, Saha, Sreoshy, Nune, Arvind, Pande, Arun Kumar R., Velikova, Tsvetelina, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Boro, Hiya, Agarwal, Vikas, Aggarwal, Rohit, Gupta, Latika, Chatterjee, Tulika, Ravichandran, Naveen, Nair, Narmadha, Gracia-Ramos, Abraham Edgar, Barman, Bhupen, Sen, Parikshit, Joshi, Mrudula, Saha, Sreoshy, Nune, Arvind, Pande, Arun Kumar R., Velikova, Tsvetelina, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Boro, Hiya, Agarwal, Vikas, Aggarwal, Rohit, and Gupta, Latika
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AIMS/INTRODUCTION: Coronavirus disease 2019 (COVID-19) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type 1 diabetes are scarce. This study aimed to evaluate the frequency and severity of short-term (<7-day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients. MATERIALS AND METHODS: This study analyzed data from the COVID-19 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing <7-day COVID-19 vaccine AE among type 1 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out. RESULTS: This study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type 1 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type 1 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type 1 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7-36), P = 0.007), although reassuringly, these were rare (n = 2 among type 1 diabetes patients). CONCLUSIONS: COVID-19 vaccination was safe and well tolerated in patients with type 1 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type 1 diabetes patients.
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- 2024
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33. Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis : survival analysis from a multicentre international patient-reported survey
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Ahmed, Sakir, Gupta, Latika, Kuwana, Masataka, Pauling, John D., Day, Jessica, Ravichandran, Naveen, Joshi, Mrudula, Parodis, Ioannis, Sen, Parikshit, Jagtap, Kshitij, Nikiphorou, Elena, Saha, Sreoshy, Agarwal, Vishwesh, Chatterjee, Tulika, Lilleker, James B., Kardes, Sinan, Milchert, Marcin, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Tan, Ai Lyn, Nune, Arvind, Cavagna, Lorenzo, Saavedra, Miguel A., Shinjo, Samuel Katsuyuki, Ziade, Nelly, Knitza, Johannes, Distler, Oliver, Wibowo, Suryo Anggoro Kusumo, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, Makol, Ashima, Ahmed, Sakir, Gupta, Latika, Kuwana, Masataka, Pauling, John D., Day, Jessica, Ravichandran, Naveen, Joshi, Mrudula, Parodis, Ioannis, Sen, Parikshit, Jagtap, Kshitij, Nikiphorou, Elena, Saha, Sreoshy, Agarwal, Vishwesh, Chatterjee, Tulika, Lilleker, James B., Kardes, Sinan, Milchert, Marcin, Gheita, Tamer, Salim, Babur, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Tan, Ai Lyn, Nune, Arvind, Cavagna, Lorenzo, Saavedra, Miguel A., Shinjo, Samuel Katsuyuki, Ziade, Nelly, Knitza, Johannes, Distler, Oliver, Wibowo, Suryo Anggoro Kusumo, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, and Makol, Ashima
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This study aimed to assess the incidence, predictors, and outcomes of breakthrough infection (BI) following coronavirus disease (COVID-19) vaccination in patients with systemic sclerosis (SSc), a risk group associated with an immune-suppressed state and high cardiopulmonary disease burden. Cross-sectional data from fully vaccinated respondents with SSc, non-SSc autoimmune rheumatic diseases (AIRDs), and healthy controls (HCs) were extracted from the COVAD database, an international self-reported online survey. BI was defined according to the Centre for Disease Control definition. Infection-free survival was compared between the groups using Kaplan-Meier curves with log-rank tests. Cox proportional regression was used to assess the association between BI and age, sex, ethnicity, and immunosuppressive drugs at the time of vaccination. The severity of BI in terms of hospitalization and requirement for oxygen supplementation was compared between groups. Of 10,900 respondents, 6836 fulfilled the following inclusion criteria: 427 SSc, 2934 other AIRDs, and 3475 HCs. BI were reported in 6.3% of SSc, 6.9% of non-SSc AIRD, and 16.1% of HCs during a median follow-up of 100 (IQR: 60-137) days. SSc had a lower risk for BI than HC [hazard ratio (HR): 0.56 (95% CI 0.46-0.74)]. BIs were associated with age [HR: 0.98 (0.97-0.98)] but not ethnicity or immunosuppressive drugs at the time of vaccination. Patients with SSc were more likely to have asymptomatic COVID-19, but symptomatic patients reported more breathlessness. Hospitalization [SSc: 4 (14.8%), HCs: 37 (6.6%), non-SSc AIRDs: 32(15.8%)] and the need for oxygenation [SSc: 1 (25%); HC: 17 (45.9%); non-SSc AIRD: 13 (40.6%)] were similar between the groups. The incidence of BI in SSc was lower than that in HCs but comparable to that in non-SSc AIRDs. The severity of BI did not differ between the groups. Advancing age, but not ethnicity or immunosuppressive medication use, was associated with BIs.
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- 2024
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34. Marketing Strategies Towards Customer Level of Satisfaction of David’s Tea House Restaurant in Quirino Highway Novaliches Quezon City: An Assessment: Vol.4, No.1
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Abraham, Rechellyn, Timtiman Jr, Noel, Tomenio, Julieto, Ty, Syries Jean, Abraham, Rechellyn, Timtiman Jr, Noel, Tomenio, Julieto, and Ty, Syries Jean
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David’s Tea House has an above-level facility that offers Chinese and Filipino cuisine likehot soup, dim sum, congee, noodle soup, and fried rice. They also offer catering events forcorporate events, special events, and birthday parties. The purpose of this study is todetermine the assessment of marketing strategies towards customer level of satisfaction ofDavid’s Tea House Restaurant in Quirino Highway Novaliches, Quezon City, and how theysatisfy their customers in terms of product, price, place, and promotion. The researchers found that employed and unemployed customers in terms of product andplace obtained a verbal interpretation of strongly satisfied, and in terms of price, theemployed obtained a verbal interpretation of strongly satisfied and the unemployed obtainedsatisfied. The employed and unemployed were promoted with a verbal interpretation ofsatisfied. It concludes that there is no significant difference between them in terms ofproduct, price, place, and promotion. The problem encountered by the employed obtained acomposite weighted mean of 4.4, or 88 percent, and the Unemployed obtained 5.6, or 112%. Overall, the researchers recommend making healthy drinks like fruit shakes and combiningthem with the products they purchased, improving their social media advertising, beingcreative and making partnerships with vloggers or famous artists who can promote theirproducts through social media, making a schedule once or twice a week, and giving littlesamples of their products out in the open 100 meters from the store. Also, they must give afree taste. Build more signage about their products or stores to let more customers know thatthey have an existing business near them.
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- 2024
35. Level of Satisfaction in the Health Care Service at Barangay Gulod Quezon City: Basis for a Proposed Improvement Plan: Vol.4, No.1
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Abraham, Raymark Jay, Castro, Miles Romel, Ferrer, Ma Joana Antonette, Hingpis, Rodgie, Abraham, Raymark Jay, Castro, Miles Romel, Ferrer, Ma Joana Antonette, and Hingpis, Rodgie
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Barangay Health Care Center is a community-based facility that offers first aid, child healthcare, and other basic services to Barangay residents. This research aims to determine thelevel of satisfaction with the health care service provided by Barangay Gulod Quezon City.The result shows the percentage distribution of the respondents. The Demographic profileTable 1 shows age 18-59 50% and 60 above 50% with a total of 100%, while Gender Table2 shows the total number percentages of male respondents (33%) and female respondents(67%). Reliability Table 3 shows a composite mean of non-senior 3.35 and senior 3.52, withboth verbal interpretations strongly agreeing. Tangibles Table 4 shows a composite mean ofnon-seniors 3.44 with verbal interpretation strongly agree, and seniors 2.68 with verbalinterpretation agree. Vaccines and Medicine Table 5 composite mean of non-senior 2.53with verbal interpretation agree and senior 2.8 with verbal interpretation agree, Priority LaneTable 6 shows a composite mean of non-senior 2.27 with verbal interpretation disagree andsenior 3.24 with verbal interpretation agree, Records Table 7 shows a composite mean non-senior 2.57 with verbal interpretation agree and senior with verbal interpretation 2.55 agree,Responsiveness Table 8 shows a composite mean non-senior 3 with verbal interpretationagree and senior 3.19 with verbal interpretation agree, Table 9 shows the significantdifference between the assessments of non-senior and senior respondents in terms of citedvariables. It reveals that the reliability, vaccine and medicine, records, and responsivenesshave no significant differences between the two groups; however, the tangibles and prioritylane are significant for both respondents. Table 10 shows the problem and solution of theresearcher’s administrator.The researchers recommended an improvement plan to address the concerns highlighted inthe study and improve the healthcare center's service quality. These include conductingregular pa
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- 2024
36. Early life ambient air pollution, household fuel use, and under-5 mortality in Ghana
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Global Health team 1, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Planetary Health & Exposoom, Moro, Ali, Nonterah, Engelbert A, Klipstein-Grobusch, Kerstin, Oladokun, Samuel, Welaga, Paul, Ansah, Patrick O, Hystad, Perry, Vermeulen, Roel, Oduro, Abraham R, Downward, George, Global Health team 1, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Planetary Health & Exposoom, Moro, Ali, Nonterah, Engelbert A, Klipstein-Grobusch, Kerstin, Oladokun, Samuel, Welaga, Paul, Ansah, Patrick O, Hystad, Perry, Vermeulen, Roel, Oduro, Abraham R, and Downward, George
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- 2024
37. An Artificial Neural Network Model for Predicting Children at Risk of Defaulting from Routine Immunization in Nigeria
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Evwiekpaefe, Abraham Eseoghene, Lawi, Valerie Plangnan, Evwiekpaefe, Abraham Eseoghene, and Lawi, Valerie Plangnan
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It has been widely recognized that immunization remains one of the most successful for decreasing child mortality rates and preventing several serious childhood diseases globally. This study proposed a prediction model for accurate identification of routine immunization defaulters in Nigeria. The proposed framework classified defaulters at five different risk stages: insignificant risk, minor risk, moderate risk, major risk and severe risk to reinforce targeted interventions by accurately predicting children at risk of defaulting from the immunization schedule. Data from Nigerian Demographic and Health Survey 2018 was obtained for this study and thirty-four (34) demographic and socio-economic factors were used to predict children at risk of defaulting from routine immunization in Nigeria by using Artificial Neural Network (ANN) to train the dataset. The results indicated that ANN model produced an accuracy of 99.16% for correctly identifying children who are likely to default from immunization series at different risk stages. Other performance measures include Precision of 99%, Recall of 99% and F1 Score of 99%. The model was further validated using one thousand (1000) dataset, out of which nine hundred and seventy four (974) were correctly predicted.
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- 2024
38. Neurological phenotype of adenosine deaminase 2 deficient patients: a cohort study
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MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Reumatologie, Cluster B, Immuno/reuma patientenzorg, Child Health, Verschoof, Merelijne A, van Meenen, Laura C C, Andriessen, M Valérie E, Brinkman, Daniëlle M C, Kamphuis, Sylvia, Kuijpers, Taco W, Leavis, Helen L, Legger, G Elizabeth, Mulders-Manders, Catharina M, de Pagter, Anne P J, Rutgers, Abraham, van Well, Gijs T J, Coutinho, Jonathan M, Hak, A Elisabeth, van Montfrans, Joris M, Klouwer, Femke C C, MS Reumatologie/Immunologie/Infectie, Infection & Immunity, Reumatologie, Cluster B, Immuno/reuma patientenzorg, Child Health, Verschoof, Merelijne A, van Meenen, Laura C C, Andriessen, M Valérie E, Brinkman, Daniëlle M C, Kamphuis, Sylvia, Kuijpers, Taco W, Leavis, Helen L, Legger, G Elizabeth, Mulders-Manders, Catharina M, de Pagter, Anne P J, Rutgers, Abraham, van Well, Gijs T J, Coutinho, Jonathan M, Hak, A Elisabeth, van Montfrans, Joris M, and Klouwer, Femke C C
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- 2024
39. Daphne-programmet - En systematisk litteraturöversikt av EU:s interventionsprogram för att minska våld mot kvinnor inom EU
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Abraham, Devora, Hoppstadius, Ida, Abraham, Devora, and Hoppstadius, Ida
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- 2024
40. Association between parental psychiatric disorders and risk of offspring autism spectrum disorder: a Swedish and Finnish population-based cohort study
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Yin, Weiyao, Pulakka, Anna, Reichenberg, Abraham, Kolevzon, Alexander, Ludvigsson, Jonas F., Risnes, Kari, Lahti-Pulkkinen, Marius, Persson, Martina, Silverman, Michael E., Ådén, Ulrika, Kajantie, Eero, Sandin, Sven, Yin, Weiyao, Pulakka, Anna, Reichenberg, Abraham, Kolevzon, Alexander, Ludvigsson, Jonas F., Risnes, Kari, Lahti-Pulkkinen, Marius, Persson, Martina, Silverman, Michael E., Ådén, Ulrika, Kajantie, Eero, and Sandin, Sven
- Abstract
Background Roughly more than one in six adults worldwide suffer from psychiatric conditions. Sporadic studies have associated parental psychiatric disorders with autism spectrum disorder in offspring. Comprehensively examining the association between parental psychiatric disorders and offspring autism spectrum disorder is needed to guide health policies, and to inform etiologic studies. Methods We included all children born in Sweden and Finland 1997 - 2016. Diagnoses were clinically ascertained from National Registers through 2017. We calculated adjusted hazard ratios (aHRs) and 95% con fi dence intervals (CIs) for autism spectrum disorder in offspring of fathers and mothers with psychiatric disorders, in both parents jointly and across co-occurring conditions. Findings Among 2,505,842 children, 33,612 were diagnosed with autism spectrum disorder, of which 20% had a parent with psychiatric disorders. The risk of autism spectrum disorder was increased across all psychiatric disorders in fathers (Sweden: aHR = 2.02, 95% CI = 1.92 - 2.12; Finland: aHR = 1.63, 95% CI = 1.50 - 1.77), mothers (Sweden: aHR = 2.34, 95% CI = 2.24 - 2.43; Finland aHR = 2.12, 95% CI = 1.92 - 2.28), or both parents (Sweden: aHR = 3.76, 95% CI = 3.48 - 4.07; Finland aHR = 3.61, 95% CI = 3.20 - 4.07), compared to neither parents. Co -occurrence of parental psychiatric disorders further increased risk (e.g., Sweden: for one, two or >= three different diagnostic categories compared to no diagnosis, in fathers aHR = 1.81, 2.07, 2.52; in mothers aHR = 2.05, 2.63, 3.57). Interpretation Psychiatric disorders in both parents conveyed the highest risk of offspring autism spectrum disorder, followed by mothers and then fathers. The risk increased with number of co-occurring disorders. All parental psychiatric disorders were associated with increased the risk of autism spectrum disorder. To reliably assess the risk of autism spectrum disorder in children, a comprehensive history incorporating the f, Funding Agencies|Swedish-Research-Council
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- 2024
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41. Relapse after electric barrier-induced voluntary abstinence: A review
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Negishi, Kenichiro, Fredriksson, Ida, Bossert, Jennifer M., Zangen, Abraham, Shaham, Yavin, Negishi, Kenichiro, Fredriksson, Ida, Bossert, Jennifer M., Zangen, Abraham, and Shaham, Yavin
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Relapse to drug use during abstinence is a defining feature of addiction. To date, however, results from studies using rat relapse/reinstatement models have yet to result in FDAapproved medications for relapse prevention. To address this translational gap, we and others have developed rat models of relapse after voluntary abstinence from drug selfadministration. One of these models is the electric barrier conflict model. Here, we introduce the model, and then review studies on behavioral and neuropharmacological mechanisms of cue-induced relapse and incubation of drug seeking (timedependent increase in drug seeking during abstinence) after electric barrier-induced abstinence. We also briefly discuss future directions and potential clinical implications. One major conclusion of our review is that the brain mechanisms controlling drug relapse after electrical barrier-induced voluntary abstinence are likely distinct from those controlling relapse after homecage forced abstinence., Funding Agencies|NIH [1ZIADA000434-23]; Swedish Research Council Starting funds [2022-01538]; Swedish Society of Medical Research Starting Grant [SG-22-0118]
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- 2024
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42. The Alopecia Areata Severity and Morbidity Index (ASAMI) Study
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Group, ASAMI Consensus Survey Study, Group, ASAMI Consensus Survey Study, Moussa, Anthony, Bennett, Michaela, Wall, Dmitri, Meah, Nekma, York, Katherine, Bokhari, Laita, Asfour, Leila, Rees, Huw, Abraham, Leonardo Spagnol, Asz-Sigall, Daniel, Basmanav, Fitnat Buket, Bergfeld, Wilma, Betz, Regina C, Bhoyrul, Bevin, Blume-Peytavi, Ulrike, Callender, Valerie, Chitreddy, Vijaya, Combalia, Andrea, Cotsarelis, George, Craiglow, Brittany, Dhurat, Rachita, Donovan, Jeff, Doroshkevich, Andrei, Eisman, Samantha, Farrant, Paul, Ferrando, Juan, Gadzhigoroeva, Aida, Green, Jack, Grimalt, Ramon, Harries, Matthew, Hordinsky, Maria, Irvine, Alan, Jolliffe, Victoria, Kaiumov, Spartak, King, Brett, Lee, Joyce, Lee, Won-Soo, Li, Jane, Lortkipanidze, Nino, McMichael, Amy, Mesinkovska, Natasha Atanaskova, Messenger, Andrew, Mirmirani, Paradi, Olsen, Elise, Orlow, Seth J, Ovcharenko, Yuliya, Piraccini, Bianca Maria, Pirmez, Rodrigo, Rakowska, Adriana, Reygagne, Pascal, Rudnicka, Lidia, Corralo, David Saceda, Senna, Maryanne, Shapiro, Jerry, Sharma, Pooja, Siliuk, Tatiana, Starace, Michela, Suchonwanit, Poonkiat, Takwale, Anita, Tosti, Antonella, Vañó-Galván, Sergio, Visser, Willem I, Vogt, Annika, Wade, Martin, Yip, Leona, Zhou, Cheng, Sinclair, Rodney, Group, ASAMI Consensus Survey Study, Group, ASAMI Consensus Survey Study, Moussa, Anthony, Bennett, Michaela, Wall, Dmitri, Meah, Nekma, York, Katherine, Bokhari, Laita, Asfour, Leila, Rees, Huw, Abraham, Leonardo Spagnol, Asz-Sigall, Daniel, Basmanav, Fitnat Buket, Bergfeld, Wilma, Betz, Regina C, Bhoyrul, Bevin, Blume-Peytavi, Ulrike, Callender, Valerie, Chitreddy, Vijaya, Combalia, Andrea, Cotsarelis, George, Craiglow, Brittany, Dhurat, Rachita, Donovan, Jeff, Doroshkevich, Andrei, Eisman, Samantha, Farrant, Paul, Ferrando, Juan, Gadzhigoroeva, Aida, Green, Jack, Grimalt, Ramon, Harries, Matthew, Hordinsky, Maria, Irvine, Alan, Jolliffe, Victoria, Kaiumov, Spartak, King, Brett, Lee, Joyce, Lee, Won-Soo, Li, Jane, Lortkipanidze, Nino, McMichael, Amy, Mesinkovska, Natasha Atanaskova, Messenger, Andrew, Mirmirani, Paradi, Olsen, Elise, Orlow, Seth J, Ovcharenko, Yuliya, Piraccini, Bianca Maria, Pirmez, Rodrigo, Rakowska, Adriana, Reygagne, Pascal, Rudnicka, Lidia, Corralo, David Saceda, Senna, Maryanne, Shapiro, Jerry, Sharma, Pooja, Siliuk, Tatiana, Starace, Michela, Suchonwanit, Poonkiat, Takwale, Anita, Tosti, Antonella, Vañó-Galván, Sergio, Visser, Willem I, Vogt, Annika, Wade, Martin, Yip, Leona, Zhou, Cheng, and Sinclair, Rodney
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ImportanceCurrent measures of alopecia areata (AA) severity, such as the Severity of Alopecia Tool score, do not adequately capture overall disease impact.ObjectiveTo explore factors associated with AA severity beyond scalp hair loss, and to support the development of the Alopecia Areata Severity and Morbidity Index (ASAMI).Evidence reviewA total of 74 hair and scalp disorder specialists from multiple continents were invited to participate in an eDelphi project consisting of 3 survey rounds. The first 2 sessions took place via a text-based web application following the Delphi study design. The final round took place virtually among participants via video conferencing software on April 30, 2022.FindingsOf all invited experts, 64 completed the first survey round (global representation: Africa [4.7%], Asia [9.4%], Australia [14.1%], Europe [43.8%], North America [23.4%], and South America [4.7%]; health care setting: public [20.3%], private [28.1%], and both [51.6%]). A total of 58 specialists completed the second round, and 42 participated in the final video conference meeting. Overall, consensus was achieved in 96 of 107 questions. Several factors, independent of the Severity of Alopecia Tool score, were identified as potentially worsening AA severity outcomes. These factors included a disease duration of 12 months or more, 3 or more relapses, inadequate response to topical or systemic treatments, rapid disease progression, difficulty in cosmetically concealing hair loss, facial hair involvement (eyebrows, eyelashes, and/or beard), nail involvement, impaired quality of life, and a history of anxiety, depression, or suicidal ideation due to or exacerbated by AA. Consensus was reached that the Alopecia Areata Investigator Global Assessment scale adequately classified the severity of scalp hair loss.Conclusions and relevanceThis eDelphi survey study, with consensus among global experts, identified various determinants of AA severity, encompassing not only scalp hair los
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- 2024
43. COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report.
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McDonnell, John, McDonnell, John, Cousins, Kimberley, Younger, M, Lane, Adam, Abolhassani, Hassan, Abraham, Roshini, Al-Tamemi, Salem, Aldave-Becerra, Juan, Al-Faris, Eman, Alfaro-Murillo, Alberto, AlKhater, Suzan, Alsaati, Nouf, Doss, Alexa, Anderson, Melissa, Angarola, Ernestina, Ariue, Barbara, Arnold, Danielle, Assaad, Amal, Aytekin, Caner, Bank, Meaghan, Bergerson, Jenna, Bleesing, Jack, Boesing, John, Bouso, Carolina, Brodszki, Nicholas, Cabanillas, Diana, Cady, Carol, Callahan, Meghan, Caorsi, Roberta, Carbone, Javier, Carrabba, Maria, Castagnoli, Riccardo, Catanzaro, Jason, Chan, Samantha, Chandra, Sharat, Chapdelaine, Hugo, Chavoshzadeh, Zahra, Chong, Hey, Connors, Lori, Consonni, Filippo, Correa-Jimenez, Oscar, Cunningham-Rundles, Charlotte, DAstous-Gauthier, Katherine, Delmonte, Ottavia, Demirdag, Yesim, Deshpande, Deepti, Diaz-Cabrera, Natalie, Dimitriades, Victoria, El-Owaidy, Rasha, ElGhazali, Gehad, Al-Hammadi, Suleiman, Fabio, Giovanna, Faure, Astrid, Feng, Jin, Fernandez, James, Fill, Lauren, Franco, Guacira, Frenck, Robert, Fuleihan, Ramsay, Giardino, Giuliana, Galant-Swafford, Jessica, Gambineri, Eleonora, Garabedian, Elizabeth, Geerlinks, Ashley, Goudouris, Ekaterini, Grecco, Octavio, Pan-Hammarström, Qiang, Khani, Hedieh, Hammarström, Lennart, Hartog, Nicholas, Heimall, Jennifer, Hernandez-Molina, Gabriela, Horner, Caroline, Hostoffer, Robert, Hristova, Nataliya, Hsiao, Kuang-Chih, Ivankovich-Escoto, Gabriela, Jaber, Faris, Jalil, Maaz, Jamee, Mahnaz, Jean, Tiffany, Jeong, Stephanie, Jhaveri, Devi, Jordan, Michael, Joshi, Avni, Kalkat, Amanpreet, Kanarek, Henry, Kellner, Erinn, Khojah, Amer, Khoury, Ruby, Kokron, Cristina, Kumar, Ashish, Lecerf, Kelsey, Lehman, Heather, Leiding, Jennifer, Lesmana, Harry, Lim, Xin, Lopes, Joao, López, Ana, Tarquini, Lucia, McDonnell, John, McDonnell, John, Cousins, Kimberley, Younger, M, Lane, Adam, Abolhassani, Hassan, Abraham, Roshini, Al-Tamemi, Salem, Aldave-Becerra, Juan, Al-Faris, Eman, Alfaro-Murillo, Alberto, AlKhater, Suzan, Alsaati, Nouf, Doss, Alexa, Anderson, Melissa, Angarola, Ernestina, Ariue, Barbara, Arnold, Danielle, Assaad, Amal, Aytekin, Caner, Bank, Meaghan, Bergerson, Jenna, Bleesing, Jack, Boesing, John, Bouso, Carolina, Brodszki, Nicholas, Cabanillas, Diana, Cady, Carol, Callahan, Meghan, Caorsi, Roberta, Carbone, Javier, Carrabba, Maria, Castagnoli, Riccardo, Catanzaro, Jason, Chan, Samantha, Chandra, Sharat, Chapdelaine, Hugo, Chavoshzadeh, Zahra, Chong, Hey, Connors, Lori, Consonni, Filippo, Correa-Jimenez, Oscar, Cunningham-Rundles, Charlotte, DAstous-Gauthier, Katherine, Delmonte, Ottavia, Demirdag, Yesim, Deshpande, Deepti, Diaz-Cabrera, Natalie, Dimitriades, Victoria, El-Owaidy, Rasha, ElGhazali, Gehad, Al-Hammadi, Suleiman, Fabio, Giovanna, Faure, Astrid, Feng, Jin, Fernandez, James, Fill, Lauren, Franco, Guacira, Frenck, Robert, Fuleihan, Ramsay, Giardino, Giuliana, Galant-Swafford, Jessica, Gambineri, Eleonora, Garabedian, Elizabeth, Geerlinks, Ashley, Goudouris, Ekaterini, Grecco, Octavio, Pan-Hammarström, Qiang, Khani, Hedieh, Hammarström, Lennart, Hartog, Nicholas, Heimall, Jennifer, Hernandez-Molina, Gabriela, Horner, Caroline, Hostoffer, Robert, Hristova, Nataliya, Hsiao, Kuang-Chih, Ivankovich-Escoto, Gabriela, Jaber, Faris, Jalil, Maaz, Jamee, Mahnaz, Jean, Tiffany, Jeong, Stephanie, Jhaveri, Devi, Jordan, Michael, Joshi, Avni, Kalkat, Amanpreet, Kanarek, Henry, Kellner, Erinn, Khojah, Amer, Khoury, Ruby, Kokron, Cristina, Kumar, Ashish, Lecerf, Kelsey, Lehman, Heather, Leiding, Jennifer, Lesmana, Harry, Lim, Xin, Lopes, Joao, López, Ana, and Tarquini, Lucia
- Abstract
BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI. OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI. METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022. RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission. CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.
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- 2024
44. Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment.
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Keller, Michael, Keller, Michael, Hanley, Patrick, Chi, Yueh-Yun, Aguayo-Hiraldo, Paibel, Verneris, Michael, Kohn, Donald, Pai, Sung-Yun, Dávila Saldaña, Blachy, Hanisch, Benjamin, Quigg, Troy, Adams, Roberta, Dahlberg, Ann, Chandrakasan, Shanmuganathan, Hasan, Hasibul, Malvar, Jemily, Jensen-Wachspress, Mariah, Lazarski, Christopher, Sani, Gelina, Idso, John, Lang, Haili, Chansky, Pamela, McCann, Chase, Tanna, Jay, Abraham, Allistair, Webb, Jennifer, Shibli, Abeer, Keating, Amy, Satwani, Prakash, Muranski, Pawel, Hall, Erin, Eckrich, Michael, Shereck, Evan, Miller, Holly, Mamcarz, Ewelina, Agarwal, Rajni, Vander Lugt, Mark, Ebens, Christen, Aquino, Victor, Bednarski, Jeffrey, Chu, Julia, Parikh, Suhag, Whangbo, Jennifer, Lionakis, Michail, Zambidis, Elias, Gourdine, Elizabeth, Bollard, Catherine, Pulsipher, Michael, Dvorak, Christopher, De Oliveira, Satiro, Keller, Michael, Keller, Michael, Hanley, Patrick, Chi, Yueh-Yun, Aguayo-Hiraldo, Paibel, Verneris, Michael, Kohn, Donald, Pai, Sung-Yun, Dávila Saldaña, Blachy, Hanisch, Benjamin, Quigg, Troy, Adams, Roberta, Dahlberg, Ann, Chandrakasan, Shanmuganathan, Hasan, Hasibul, Malvar, Jemily, Jensen-Wachspress, Mariah, Lazarski, Christopher, Sani, Gelina, Idso, John, Lang, Haili, Chansky, Pamela, McCann, Chase, Tanna, Jay, Abraham, Allistair, Webb, Jennifer, Shibli, Abeer, Keating, Amy, Satwani, Prakash, Muranski, Pawel, Hall, Erin, Eckrich, Michael, Shereck, Evan, Miller, Holly, Mamcarz, Ewelina, Agarwal, Rajni, Vander Lugt, Mark, Ebens, Christen, Aquino, Victor, Bednarski, Jeffrey, Chu, Julia, Parikh, Suhag, Whangbo, Jennifer, Lionakis, Michail, Zambidis, Elias, Gourdine, Elizabeth, Bollard, Catherine, Pulsipher, Michael, Dvorak, Christopher, and De Oliveira, Satiro
- Abstract
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus. Primary endpoints were feasibility, safety, and clinical responses (>1 log reduction in viremia at 28 days). Secondary endpoints were reconstitution of antiviral immunity and persistence of the infused VSTs. Suitable VST products were identified for 75 of 77 clinical queries. Clinical responses were achieved in 29 of 47 (62%) of patients post-HSCT including 73% of patients evaluable at 1-month post-infusion, meeting the primary efficacy endpoint (>52%). Secondary graft rejection occurred in one child following VST infusion as described in a companion article. Corticosteroids, graft-versus-host disease, transplant-associated thrombotic microangiopathy, and eculizumab treatment correlated with poor response, while uptrending absolute lymphocyte and CD8 T cell counts correlated with good response. This study highlights key clinical factors that impact response to VSTs and demonstrates the feasibility and efficacy of this therapy in pediatric HSCT.
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- 2024
45. A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats
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de Jong, Tristan V, de Jong, Tristan V, Pan, Yanchao, Rastas, Pasi, Munro, Daniel, Tutaj, Monika, Akil, Huda, Benner, Chris, Chen, Denghui, Chitre, Apurva S, Chow, William, Colonna, Vincenza, Dalgard, Clifton L, Demos, Wendy M, Doris, Peter A, Garrison, Erik, Geurts, Aron M, Gunturkun, Hakan M, Guryev, Victor, Hourlier, Thibaut, Howe, Kerstin, Huang, Jun, Kalbfleisch, Ted, Kim, Panjun, Li, Ling, Mahaffey, Spencer, Martin, Fergal J, Mohammadi, Pejman, Ozel, Ayse Bilge, Polesskaya, Oksana, Pravenec, Michal, Prins, Pjotr, Sebat, Jonathan, Smith, Jennifer R, Solberg Woods, Leah C, Tabakoff, Boris, Tracey, Alan, Uliano-Silva, Marcela, Villani, Flavia, Wang, Hongyang, Sharp, Burt M, Telese, Francesca, Jiang, Zhihua, Saba, Laura, Wang, Xusheng, Murphy, Terence D, Palmer, Abraham A, Kwitek, Anne E, Dwinell, Melinda R, Williams, Robert W, Li, Jun Z, Chen, Hao, de Jong, Tristan V, de Jong, Tristan V, Pan, Yanchao, Rastas, Pasi, Munro, Daniel, Tutaj, Monika, Akil, Huda, Benner, Chris, Chen, Denghui, Chitre, Apurva S, Chow, William, Colonna, Vincenza, Dalgard, Clifton L, Demos, Wendy M, Doris, Peter A, Garrison, Erik, Geurts, Aron M, Gunturkun, Hakan M, Guryev, Victor, Hourlier, Thibaut, Howe, Kerstin, Huang, Jun, Kalbfleisch, Ted, Kim, Panjun, Li, Ling, Mahaffey, Spencer, Martin, Fergal J, Mohammadi, Pejman, Ozel, Ayse Bilge, Polesskaya, Oksana, Pravenec, Michal, Prins, Pjotr, Sebat, Jonathan, Smith, Jennifer R, Solberg Woods, Leah C, Tabakoff, Boris, Tracey, Alan, Uliano-Silva, Marcela, Villani, Flavia, Wang, Hongyang, Sharp, Burt M, Telese, Francesca, Jiang, Zhihua, Saba, Laura, Wang, Xusheng, Murphy, Terence D, Palmer, Abraham A, Kwitek, Anne E, Dwinell, Melinda R, Williams, Robert W, Li, Jun Z, and Chen, Hao
- Abstract
The seventh iteration of the reference genome assembly for Rattus norvegicus-mRatBN7.2-corrects numerous misplaced segments and reduces base-level errors by approximately 9-fold and increases contiguity by 290-fold compared with its predecessor. Gene annotations are now more complete, improving the mapping precision of genomic, transcriptomic, and proteomics datasets. We jointly analyzed 163 short-read whole-genome sequencing datasets representing 120 laboratory rat strains and substrains using mRatBN7.2. We defined ∼20.0 million sequence variations, of which 18,700 are predicted to potentially impact the function of 6,677 genes. We also generated a new rat genetic map from 1,893 heterogeneous stock rats and annotated transcription start sites and alternative polyadenylation sites. The mRatBN7.2 assembly, along with the extensive analysis of genomic variations among rat strains, enhances our understanding of the rat genome, providing researchers with an expanded resource for studies involving rats.
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- 2024
46. El Aprendizaje y La Enseñanza del Cálculo Diferencial: Perspectivas desde las Teorías APOE y Ontoseomiótica
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Rico Segura, Abraham and Rico Segura, Abraham
- Abstract
This article addresses the challenge of teaching and learning differential calculus in higher education, especially in engineering, highlighting the need for innovative pedagogical methods to understand abstract concepts and develop critical thinking. It proposes a theoretical approach based on variational thinking, the Ontosemiotic Approach, and APOE Theories, integrating these perspectives to significantly improve the teaching of differential calculus. Through a systematic review following PRISMA, the study identifies effective didactic strategies, assesses their impact on learning, and suggests areas for future research. Although it faces challenges such as resistance to change and the need for specific resources and teacher training, this approach promises a deeper understanding of mathematical concepts and better preparation of students for real-world applications and scientific disciplines., Este artículo aborda el desafío de enseñar y aprender cálculo diferencial en educación superior, especialmente en ingeniería, destacando la necesidad de métodos pedagógicos innovadores para comprender conceptos abstractos y desarrollar un pensamiento crítico. Propone una aproximación teórica basada en el pensamiento variacional, el Enfoque Ontosemiótico y las Teorías APOE, integrando estas perspectivas para mejorar significativamente la enseñanza del cálculo diferencial. Mediante una revisión sistemática siguiendo PRISMA, el estudio identifica estrategias didácticas eficaces, evalúa su impacto en el aprendizaje y sugiere áreas para futura investigación. Aunque enfrenta desafíos como la resistencia al cambio y la necesidad de recursos y formación docente específicos, este enfoque promete una comprensión más profunda de los conceptos matemáticos y una mejor preparación de los estudiantes para aplicaciones reales y disciplinas científicas.
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- 2024
47. Los indicadores financieros y no financieros como herramientas de gestión en el sector ferretero
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Villa Cueva, Johanna Alexandra, Crespo Córdova, Abraham Boanerges, Villa Cueva, Johanna Alexandra, and Crespo Córdova, Abraham Boanerges
- Abstract
The study conducted aimed to identify financial and non-financial performance indicators and their importance in evaluating the management of the wholesale activity of hardware stores. To achieve this goal, a qualitative descriptive methodology was used. The process began with a literature review, afterwards qualitative interviews were applied to 20 managers of companies engaged in the wholesale trade of hardware items. In the literature, it was found that it is advisable to define management indicators based on key success factors, and, on the other hand, regarding practice, it was found that companies in the sector under study are evaluated by financial indicators (liquidity, profitability, indebtedness, etc.) and non-financial indicators (labor productivity, return rate, etc.). Finally, the results allowed concluding that the use of these types of key performance indicators is important, as they enable the evaluation of companies, thereby potentiating their entrepreneurial success and promoting the adoption of accurate decisions., O objetivo do estudo foi identificar os indicadores de desempenho financeiro e não financeiro e sua importância na avaliação da gestão de empresas do setor de hardware. Para atingir esse objetivo, foi utilizada como metodologia uma abordagem descritiva e qualitativa. Em um primeiro momento, em um contexto geral e de nível macro, foi realizada uma revisão da literatura, seguida de entrevistas qualitativas com 20 gerentes ou proprietários das empresas envolvidas na atividade de atacado de artigos de ferragens e, dessa forma, as informações coletadas por ambos os meios foram combinadas. Na literatura, constatou-se que é aconselhável definir indicadores de gestão em termos de fatores-chave de sucesso e, por outro lado, em relação à prática, verificou-se que as empresas do setor em estudo são avaliadas por indicadores financeiros (liquidez, lucratividade, endividamento etc.) e não financeiros (produtividade do trabalho, taxa de retorno etc.). Por fim, os resultados levaram à conclusão de que o uso desse tipo de indicadores-chave de gestão é importante, pois permite que as empresas sejam avaliadas de modo a aumentar o sucesso de seus negócios e promover a tomada de decisões sólidas., El estudio desarrollado tuvo como propósito identificar los indicadores de desempeño financieros y no financieros y su importancia en la evaluación de la gestión de las empresas que integran el sector ferretero. Para cumplir con dicho objetivo se utilizó como metodología un enfoque cualitativo, de tipo descriptivo. En primera instancia, en un contexto general, de nivel macro se efectúo una revisión de la literatura, para luego, realizar entrevistas cualitativas a 20 gerentes o dueños de las empresas bajo la actividad correspondiente a la venta al por mayor de artículos de ferreterías y, de esta manera emparejar la información recolectada por ambos medios. En la literatura, se halló que es recomendable definir los indicadores de gestión en función de los factores claves de éxito, y, por otro lado, en relación con la práctica se encontró que, las empresas del sector de estudio son evaluadas por indicadores financieros (liquidez, rentabilidad, endeudamiento, etc.) y no financieros (productividad laboral, índice de devoluciones, etc.). Finalmente, los resultados permitieron concluir que el uso de este tipo de indicadores claves de gestión son importantes, ya que, permiten evaluar a las empresas, para a partir de ello potenciar su éxito empresarial y promover la toma de decisiones acertadas.
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- 2024
48. Procesión y protesta: La resignificación del dolor de las familias en el Caso Ayotzinapa
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Díaz Delgado, Abraham Zaíd and Díaz Delgado, Abraham Zaíd
- Abstract
The Ayotzinapa Case concerns the death and forced disappearance of a group of student teachers from Guerrero (Mexico) on September 26 and 27, 2014. For more than nine years, the topic has been recurrent in the media nationally and internationally. However, the news usually frames the mass actions that take place in Mexico City (capital of the country) commonly with a disqualifying and criminalizing discourse of both the protests and the victims of forced disappearance. From 2019 to 2021, I had the opportunity to carry out ethnographic work with some families of the disappeared students and with their classmates from the Rural Normal School “Raúl Isidro Burgos” of Ayotzinapa. This photoseries exposes the manifestation of the collective process of conversion of pain and suffering into organization and social mobilization of the Mondragón Fontes family and the current students of Ayotzinapa from the case of Julio César Mondragón Fontes (JCMF), who was executed and tortured to the point of skinning his face, which is why his family and colleagues continue to demand justice and punishment for those who are responsible., El Caso Ayotzinapa refiere a la muerte y desaparición forzada de un grupo de estudiantes normalistas de Guerrero (México), entre los días 26 y 27 de septiembre del 2014. A lo largo de más de nueve años, el tema ha sido recurrente en los medios de comunicación nacional e internacionalmente. No obstante, las noticias suelen encuadrar las acciones multitudinarias que se llevan a cabo en la Ciudad de México, capital del país, comúnmente con un discurso descalificante y criminalizador, tanto de las protestas como de las víctimas de la desaparición forzada. De los años 2019 a 2021, tuve la oportunidad de realizar un trabajo etnográfico con algunas familias de los estudiantes desaparecidos y con sus compañeros de la Escuela Normal Rural “Raúl Isidro Burgos” de Ayotzinapa. Esta fotoserie expone la manifestación del proceso colectivo de conversión del dolor y del sufrimiento en organización y movilización social de la familia Mondragón Fontes y los actuales estudiantes de Ayotzinapa, a partir del caso de Julio César Mondragón Fontes (JCMF), quién fue ejecutado y torturado hasta el punto de desollarle el rostro, motivo por el cuál su familia y compañeros siguen exigiendo justicia y castigo a quienes resulten responsables.
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- 2024
49. Characteristics of emerging new autoimmune diseases after COVID-19 vaccination : A sub-study by the COVAD group
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Shumnalieva, Russka, Ravichandran, Naveen, Hannah, Jennifer, Javaid, Mahnoor, Darooka, Naitica, Roy, Debaditya, Gonzalez, Daniel E., Velikova, Tsvetelina, Milchert, Marcin, Kuwana, Masataka, Joshi, Mrudula, Gracia-Ramos, Abraham Edgar, Boyd, Peter, Yaadav, Praggya, Cheng, Karen, Kobert, Linda, Cavagna, Lorenzo, Sen, Parikshit, Day, Jessica, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Caballero-Uribe, Carlo V., Saha, Sreoshy, Parodis, Ioannis, Dey, Dzifa, Nikiphorou, Elena, Distler, Oliver, Kadam, Esha, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Ziade, Nelly, Knitza, Johannes, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, Gupta, Latika, Shumnalieva, Russka, Ravichandran, Naveen, Hannah, Jennifer, Javaid, Mahnoor, Darooka, Naitica, Roy, Debaditya, Gonzalez, Daniel E., Velikova, Tsvetelina, Milchert, Marcin, Kuwana, Masataka, Joshi, Mrudula, Gracia-Ramos, Abraham Edgar, Boyd, Peter, Yaadav, Praggya, Cheng, Karen, Kobert, Linda, Cavagna, Lorenzo, Sen, Parikshit, Day, Jessica, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Caballero-Uribe, Carlo V., Saha, Sreoshy, Parodis, Ioannis, Dey, Dzifa, Nikiphorou, Elena, Distler, Oliver, Kadam, Esha, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Ziade, Nelly, Knitza, Johannes, Chinoy, Hector, Aggarwal, Rohit, Agarwal, Vikas, and Gupta, Latika
- Abstract
BACKGROUND: Despite the overall safety and efficacy of COVID-19 vaccinations, rare cases of systemic autoimmune diseases (SAIDs) have been reported post-vaccination. This study used a global survey to analyze SAIDs in susceptible individuals' post-vaccination. METHODS: A cross-sectional study was conducted among participants with self-reported new-onset SAIDs using the COVID-19 Vaccination in Autoimmune Diseases (COVAD) 2 study dataset-a validated, patient-reported e-survey-to analyze the long-term safety of COVID-19 vaccines. Baseline characteristics of patients with new-onset SAIDs and vaccinated healthy controls (HCs) were compared after propensity score matching based on age and sex in a 1:4 ratio. RESULTS: Of 16 750 individuals, 74 (median age 52 years, 79.9% females, and 76.7% Caucasians) had new-onset SAID post-vaccination, mainly idiopathic inflammatory myopathies (IIMs) (n = 23, 31.51%), arthritis (n = 15; 20.53%), and polymyalgia rheumatica (PMR) (n = 12, 16.40%). Higher odds of new-onset SAIDs were noted among Caucasians (OR = 5.3; 95% CI = 2.9-9.7; p < .001) and Moderna vaccine recipients (OR = 2.7; 95% CI = 1.3-5.3; p = .004). New-onset SAIDs were associated with AID multimorbidity (OR = 1.4; 95% CI = 1.1-1.7; p < .001), mental health disorders (OR = 1.6; 95% CI = 1.3-1.9; p < .001), and mixed race (OR = 2.2; 95% CI = 1.2-4.2; p = .010), where those aged >60 years (OR = 0.6; 95% CI = 0.4-0.8; p = .007) and from high/medium human development index (HDI) countries (compared to very high HDI) reported fewer events than HCs. CONCLUSION: This study reports a low occurrence of new-onset SAIDs following COVID-19 vaccination, primarily IIMs, PMR, and inflammatory arthritis. Identified risk factors included pre-existing AID multimorbidity, mental health diseases, and mixed race. Revaccination was well tolerated by most patients; therefore, we recommend continuing COVID-19 vaccination in the general population. However, long-term studies are needed to
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- 2024
- Full Text
- View/download PDF
50. Collating the voice of people with autoimmune diseases : Methodology for the Third Phase of the COVAD Studies
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Kadam, Esha, Javaid, Mahnoor, Sen, Parikshit, Saha, Sreoshy, Ziade, Nelly, Day, Jessica, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Chatterjee, Tulika, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Battista, Simone, Cheng, Karen, Boyd, Peter, Kobert, Linda, Gracia-Ramos, Abraham Edgar, Mittal, Srijan, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Uribe, Carlo V Caballero, Kuwana, Masataka, Burmester, Gerd-Rüdiger, Guillemin, Francis, Nikiphorou, Elena, Chinoy, Hector, Aggarwal, Vikas, Gupta, Latika, Kadam, Esha, Javaid, Mahnoor, Sen, Parikshit, Saha, Sreoshy, Ziade, Nelly, Day, Jessica, Wincup, Chris, Andreoli, Laura, Parodis, Ioannis, Tan, Ai Lyn, Shinjo, Samuel Katsuyuki, Dey, Dzifa, Cavagna, Lorenzo, Chatterjee, Tulika, Knitza, Johannes, Wang, Guochun, Dalbeth, Nicola, Velikova, Tsvetelina, Battista, Simone, Cheng, Karen, Boyd, Peter, Kobert, Linda, Gracia-Ramos, Abraham Edgar, Mittal, Srijan, Makol, Ashima, Gutiérrez, Carlos Enrique Toro, Uribe, Carlo V Caballero, Kuwana, Masataka, Burmester, Gerd-Rüdiger, Guillemin, Francis, Nikiphorou, Elena, Chinoy, Hector, Aggarwal, Vikas, and Gupta, Latika
- Abstract
INTRODUCTION: The growing recognition of holistic patient care highlights the various factors shaping the quality of life of individuals with autoimmune and rheumatic diseases (AIRDs). Beyond the traditional disease measures, there is an emerging acknowledgment of the less-explored aspects, including subjective well-being, social determinants of health, comorbidities, mental health, and medication adherence. Moreover, digital health services have empowered patients to engage actively in decision-making alongside clinicians. To explore these domains within the context of AIRDs, the "Collating the Voice of People with Autoimmune Diseases" COVAD survey was conceived, a successor of the previous two COVAD surveys. In this document, we present the study protocol in comprehensive detail. METHODS: The COVAD-3 survey is a cross-sectional patient self-reported e-survey incorporating multiple widely accepted scales/scores to assess various aspects of patients' lifestyles objectively. To ensure the survey's accuracy and usability across diverse regions, it will be translated into multiple languages and subjected to rigorous vetting and pilot testing. It will be distributed by collaborators via online platforms and data will be collected from patients with AIRDs, and healthy individuals over eight months. Data analysis will focus on outcome measures related to various social, demographic, economic, and psychological factors. CONCLUSION: With the increasing awareness to adopt a holistic treatment approach encompassing all avenues of life, the COVAD-3 survey aims to gain valuable insights into the impact of social, demographic, economic, and psychological determinants of health on the subjective well-being in patients with AIRDs, which will contribute to a better understanding of their overall health and well-being.
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- 2024
- Full Text
- View/download PDF
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