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This subgroup analysis of a randomized clinical trial compares trifluridine/tipiracil treatment with placebo for progression-free and overall survival among patients with previously treated metastatic gastric or gastroesophageal junction cancer who had or had not undergone gastrectomy. Is trifluridine/tipiracil treatment safe and effective for the subpopulation of patients with previously treated metastatic gastric or gastroesophageal junction cancer who have undergone gastrectomy? In this subgroup analysis of a randomized clinical trial, trifluridine/tipiracil treatment improved overall survival and progression-free survival compared with placebo among patients with previously treated metastatic gastric or gastroesophageal junction cancer and who had or had not undergone gastrectomy. No new safety concerns were reported, and hematologic toxic effects were more frequent among the subgroup who had undergone gastrectomy but were treated using dosing modifications. Trifluridine/tipiracil is a safe and effective treatment option for patients with pretreated metastatic gastric or gastroesophageal junction cancer regardless of previous gastrectomy. Trifluridine/tipiracil (FTD/TPI) treatment has shown clinical benefit in patients with pretreated metastatic gastric cancer or gastroesophageal junction cancer (mGC/GEJC). Patients who have undergone gastrectomy constitute a significant proportion of patients with mGC/GEJC. To assess the efficacy and safety of FTD/TPI among patients with previously treated mGC/GEJC who had or had not undergone gastrectomy. This preplanned subgroup analysis of TAGS (TAS-102 Gastric Study), a phase 3, randomized, placebo-controlled, clinical trial included patients with mGC/GEJC who had received at least 2 previous chemotherapy regimens, and was conducted at 110 academic hospitals in 17 countries in Europe, Asia, and North America, with enrollment between February 24, 2016, and January 5, 2018; the data cutoff was March 31, 2018. Patients were ra

We investigate stability of the solution of a set of partial differential equations, which is used to model a peri-implant osseointegration process. For certain parameter values, the solution has a ‘wave-like’ profile, which appears in the distribution of osteogenic cells, osteoblasts, growth factor and bone matrix. This ‘wave-like’ profile contradicts experimental observations. In our study we investigate the conditions, under which such profile appears in the solution. Those conditions are determined in terms of model parameters, by means of linear stability analysis, carried out at one of the constant solutions of the simplified system. The stability analysis was carried out for the reduced system of PDE’s, of which we prove, that it is equivalent to the original system of equations, with respect to the stability properties of constant solutions. The conclusions, derived from the linear stability analysis, are extended for the case of large perturbations. If the constant solution is unstable, then the solution of the system never converges to this constant solution. The analytical results are validated with finite element simulations. The simulations show, that stability of the constant solution could determine the behavior of the solution of the whole system, if certain initial conditions are considered., Delft Institute of Applied Mathematics, Electrical Engineering, Mathematics and Computer Science

Applied mathematics, Electrical Engineering, Mathematics and Computer Science

We investigate stability of the solution of a set of partial differential equations, which is used to model a peri-implant osseointegration process. For certain parameter values, the solution has a ‘wave-like’ profile, which appears in the distribution of osteogenic cells, osteoblasts, growth factor and bone matrix. This ‘wave-like’ profile contradicts experimental observations. In our study we investigate the conditions, under which such profile appears in the solution. Those conditions are determined in terms of model parameters, by means of linear stability analysis, carried out at one of the constant solutions of the simplified system. The stability analysis was carried out for the reduced system of PDE’s, of which we prove, that it is equivalent to the original system of equations, with respect to the stability properties of constant solutions. The conclusions, derived from the linear stability analysis, are extended for the case of large perturbations. If the constant solution is unstable, then the solution of the system never converges to this constant solution. The analytical results are validated with finite element simulations. The simulations show, that stability of the constant solution could determine the behavior of the solution of the whole system, if certain initial conditions are considered., Delft Institute of Applied Mathematics, Electrical Engineering, Mathematics and Computer Science

Applied mathematics, Electrical Engineering, Mathematics and Computer Science

We investigate stability of the solution of the equations proposed in [Moreo, 2008], which model peri-implant osseointegration process. For certain parameter values, the solution has a ’wave-like’ profile, which appears in the distribution of osteogenic cells, osteoblasts, growth factor and bone matrix. That is in contradiction with experimental observations. In our study we investigate the conditions, under which such profile appears in the solution. Those conditions are determined in terms of model parameters, by means of linear stability analysis, carried out at one of the homogeneous steady-state solutions of the simplified system. The analysis is validated with finite element simulations. The simulations show, that stability of the homogeneous steady-state could determine the behavior of the solution of the whole system, when certain initial conditions are considered., Electrical Engineering, Mathematics and Computer Science

We investigate stability of the solution of the equations proposed in [Moreo, 2008], which model peri-implant osseointegration process. For certain parameter values, the solution has a ’wave-like’ profile, which appears in the distribution of osteogenic cells, osteoblasts, growth factor and bone matrix. That is in contradiction with experimental observations. In our study we investigate the conditions, under which such profile appears in the solution. Those conditions are determined in terms of model parameters, by means of linear stability analysis, carried out at one of the homogeneous steady-state solutions of the simplified system. The analysis is validated with finite element simulations. The simulations show, that stability of the homogeneous steady-state could determine the behavior of the solution of the whole system, when certain initial conditions are considered., Electrical Engineering, Mathematics and Computer Science

Electrical Engineering, Mathematics and Computer Science

Electrical Engineering, Mathematics and Computer Science