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El presente documento es la memoria del trabajo de fin de grado que lleva por nombre “Monitorización de pacientes con pulseras inteligentes”. Ha sido realizado por Gala M. García Sánchez, bajo la supervisión de su tutor José García Rodríguez durante el periodo 2015-2016. A día de hoy, el uso de las pulseras inteligentes para una monitorización continua de las constantes vitales del usuario está normalizado. En cambio, pese a la fiabilidad de los sensores gracias al avance tecnológico y a su abaratamiento, no es posible encontrar tan fácilmente aplicaciones destinadas a un control médico exhaustivo que contribuya a mejorar la calidad de vida de los pacientes. Con este objetivo, se ha realizado un profundo estudio orientado al desarrollo de una aplicación, capaz de detectar ataques epilépticos en personas dependientes con Daño Cerebral Adquirido. De esta forma, se pretende que los cuidadores tengan una mayor tranquilidad al poder recibir una alerta configurable cuando se esté produciendo un ataque epiléptico, logrando así mejorar su autonomía al no ser obligatoria una vigilancia presencial continua. El desarrollo de este proyecto puede dividirse en dos partes diferenciadas: teórica y práctica. En primer lugar, el apartado teórico se basa en las investigaciones realizadas previas a la programación de la aplicación. Se comenzó con el análisis de las enfermedades a las que se dirige este trabajo y de los dispositivos en las que se basaría su implementación. En consecuencia, se derivó a un estudio sobre el ámbito de la e-Salud, al que pertenece el producto final, y al Internet de las Cosas, principio esencial sobre el que se apoyan el surgimiento de la tecnología weareable y que explica la hiperconexión entre dispositivos. Por último, se realizó el estudio del mercado para la elección de la pulsera inteligente, que finalmente sería Angel Sensor, y en búsqueda de aplicaciones similares. Finalmente, el apartado práctico engloba todos los pasos seguidos para alcanzar el resu

El presente documento es la memoria del trabajo de fin de grado que lleva por nombre “Monitorización de pacientes con pulseras inteligentes”. Ha sido realizado por Gala M. García Sánchez, bajo la supervisión de su tutor José García Rodríguez durante el periodo 2015-2016. A día de hoy, el uso de las pulseras inteligentes para una monitorización continua de las constantes vitales del usuario está normalizado. En cambio, pese a la fiabilidad de los sensores gracias al avance tecnológico y a su abaratamiento, no es posible encontrar tan fácilmente aplicaciones destinadas a un control médico exhaustivo que contribuya a mejorar la calidad de vida de los pacientes. Con este objetivo, se ha realizado un profundo estudio orientado al desarrollo de una aplicación, capaz de detectar ataques epilépticos en personas dependientes con Daño Cerebral Adquirido. De esta forma, se pretende que los cuidadores tengan una mayor tranquilidad al poder recibir una alerta configurable cuando se esté produciendo un ataque epiléptico, logrando así mejorar su autonomía al no ser obligatoria una vigilancia presencial continua. El desarrollo de este proyecto puede dividirse en dos partes diferenciadas: teórica y práctica. En primer lugar, el apartado teórico se basa en las investigaciones realizadas previas a la programación de la aplicación. Se comenzó con el análisis de las enfermedades a las que se dirige este trabajo y de los dispositivos en las que se basaría su implementación. En consecuencia, se derivó a un estudio sobre el ámbito de la e-Salud, al que pertenece el producto final, y al Internet de las Cosas, principio esencial sobre el que se apoyan el surgimiento de la tecnología weareable y que explica la hiperconexión entre dispositivos. Por último, se realizó el estudio del mercado para la elección de la pulsera inteligente, que finalmente sería Angel Sensor, y en búsqueda de aplicaciones similares. Finalmente, el apartado práctico engloba todos los pasos seguidos para alcanzar el resu

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

A new spherical tokamak, the SMall Aspect Ratio Tokamak (SMART), is currently being designed at the University of Seville. The goal of the machine is to achieve a toroidal field of 1 T, a plasma current of 500 kA and a pulse length of 500 ms for a plasma with a major radius of 0.4 m and minor radius of 0.25 m. This contribution presents the design of the coils and power supplies of the machine. The design foresees a central solenoid, 12 toroidal field coils and 8 poloidal field coils. Taking the current waveforms for these set of coils as starting point, each of them has been designed to withstand the Joule heating during the tokamak operation time. An analytical thermal model is employed to obtain the cross sections of each coil and, finally, their dimensions and parameters. The design of flexible and modular power supplies, based on IGBTs and supercapacitors, is presented. The topologies and control strategy of the power supplies are explained, together with a model in MATLAB Simulink to simulate the power supplies performance, proving their feasibility before the construction of the system.

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

Cells can enter quiescence in adverse conditions and resume proliferation when the environment becomes favorable. Prolonged quiescence comes with a cost, reducing the subsequent speed and potential to return to proliferation. Here, we show that a similar process happens during Caenorhabditis elegans development, providing an in vivo model to study proliferative capacity after quiescence. Hatching under starvation provokes the arrest of blast cell divisions that normally take place during the first larval stage (L1). We have used a novel method to precisely quantify each stage of postembryonic development to analyze the consequences of prolonged L1 quiescence. We report that prolonged L1 quiescence delays the reactivation of blast cell divisions in C. elegans, leading to a delay in the initiation of postembryonic development. The transcription factor DAF‐16/FOXO is necessary for rapid recovery after extended arrest, and this effect is independent from its role as a suppressor of cell proliferation. Instead, the activation of DAF‐16 by decreased insulin signaling reduces the rate of L1 aging, increasing proliferative potential. We also show that yolk provisioning affects the proliferative potential after L1 arrest modulating the rate of L1 aging, providing a possible mechanistic link between insulin signaling and the maintenance of proliferative potential. Furthermore, variable yolk provisioning in embryos is one of the sources of interindividual variability in recovery after quiescence of genetically identical animals. Our results support the relevance of L1 arrest as an in vivo model to study stem cell‐like aging and the mechanisms for maintenance of proliferation potential after quiescence.

[SPA] La obra del arquitecto almeriense Fernando Cassinello Pérez (Almería, 1928-Madrid, 1975) se apoya sobre tres pilares: la producción arquitectónica centrada en el proyecto y construcción de viviendas y establecimientos hoteleros; la actividad académica como Catedrático de Construcción en la Escuela de Arquitectura de Madrid, y la inquietud investigadora desarrollada en el Instituto Eduardo Torroja del que llegó a ser director, y ejercida como autor de libros y artículos de investigación, como conferenciante divulgador, como ponente en importantes congresos o como miembro activo de asociaciones internacionales vinculadas a la construcción con hormigón. Este artículo hará un repaso de su prolífica actividad como arquitecto poliédrico y dará cuenta de las interesantes obras que proyectó y construyó apoyándose en una dilatada cultura arquitectónica contemporánea e internacional. [ENG] The work of architect Fernando Cassinello Pérez (Almería, 1928-Madrid, 1975) rests on three pillars: architectural production focused on the design and construction of housing and hotel establishments, academic activity as Professor of Construction at the Escuela de Arquitectura de Madrid, and research concern developed in the IETcc of which he became director, and exercised as an author of books and research papers, as disseminator lecturer, speaker at major conferences or as an active member of international associations linked to construction with concrete. This article will review his prolific activity as polyhedral architect and will find interesting works that designed and built by relying on extensive contemporary and international architectural culture.

José Pérez Ocaña (Cantillana, Sevilla, 1947-1983) desarrolló su actividad artística en Barcelona. Conocido por sus acciones públicas y convertido en un icono de la transgresión cultural de los años 70, anticipó la performance en una España que se abría a nuevos lenguajes artísticos. A su muerte, la llegada a Andalucía de sus pinturas, dibujos y objetos personales plantea la cuestión de qué papel juega este legado en el panorama del arte contemporáneo de Andalucía. La conservación y la restauración de la obra y la memoria de Ocaña requieren de un proyecto de puesta en valor, en el cual se enmarca esta ponencia. Tres metodologías se suman en la ponencia: una, desde la museología, revisa los sistemas museográficos, tanto física como virtualmente; otra, desde la perspectiva patrimonial, hace un diagnóstico y aborda sus valores patrimoniales; y la última, propiamente cultural, presenta propuestas y reflexiones sobre cómo una obra de arte se transforma en un bien cultural, convirtiéndose en un referente de interés cultural.

José Pérez Ocaña (Cantillana, Sevilla, 1947-1983) desarrolló su actividad artística en Barcelona. Conocido por sus acciones públicas y convertido en un icono de la transgresión cultural de los años 70, anticipó la performance en una España que se abría a nuevos lenguajes artísticos. A su muerte, la llegada a Andalucía de sus pinturas, dibujos y objetos personales plantea la cuestión de qué papel juega este legado en el panorama del arte contemporáneo de Andalucía. La conservación y la restauración de la obra y la memoria de Ocaña requieren de un proyecto de puesta en valor, en el cual se enmarca esta ponencia. Tres metodologías se suman en la ponencia: una, desde la museología, revisa los sistemas museográficos, tanto física como virtualmente; otra, desde la perspectiva patrimonial, hace un diagnóstico y aborda sus valores patrimoniales; y la última, propiamente cultural, presenta propuestas y reflexiones sobre cómo una obra de arte se transforma en un bien cultural, convirtiéndose en un referente de interés cultural.

José Pérez Ocaña (Cantillana, Sevilla, 1947-1983) desarrolló su actividad artística en Barcelona. Conocido por sus acciones públicas y convertido en un icono de la transgresión cultural de los años 70, anticipó la performance en una España que se abría a nuevos lenguajes artísticos. A su muerte, la llegada a Andalucía de sus pinturas, dibujos y objetos personales plantea la cuestión de qué papel juega este legado en el panorama del arte contemporáneo de Andalucía. La conservación y la restauración de la obra y la memoria de Ocaña requieren de un proyecto de puesta en valor, en el cual se enmarca esta ponencia. Tres metodologías se suman en la ponencia: una, desde la museología, revisa los sistemas museográficos, tanto física como virtualmente; otra, desde la perspectiva patrimonial, hace un diagnóstico y aborda sus valores patrimoniales; y la última, propiamente cultural, presenta propuestas y reflexiones sobre cómo una obra de arte se transforma en un bien cultural, convirtiéndose en un referente de interés cultural.

José Pérez Ocaña (Cantillana, Sevilla, 1947-1983) desarrolló su actividad artística en Barcelona. Conocido por sus acciones públicas y convertido en un icono de la transgresión cultural de los años 70, anticipó la performance en una España que se abría a nuevos lenguajes artísticos. A su muerte, la llegada a Andalucía de sus pinturas, dibujos y objetos personales plantea la cuestión de qué papel juega este legado en el panorama del arte contemporáneo de Andalucía. La conservación y la restauración de la obra y la memoria de Ocaña requieren de un proyecto de puesta en valor, en el cual se enmarca esta ponencia. Tres metodologías se suman en la ponencia: una, desde la museología, revisa los sistemas museográficos, tanto física como virtualmente; otra, desde la perspectiva patrimonial, hace un diagnóstico y aborda sus valores patrimoniales; y la última, propiamente cultural, presenta propuestas y reflexiones sobre cómo una obra de arte se transforma en un bien cultural, convirtiéndose en un referente de interés cultural.