Search

Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing data, but interpretative analysis tools specific for the testing systems (e.g. hepatocytes) are lacking. In this study, we present the TXG-MAPr webtool (available at https://txg-mapr.eu/WGCNA_PHH/TGGATEs_PHH/), an R-Shiny-based implementation of weighted gene co-expression network analysis (WGCNA) obtained from the Primary Human Hepatocytes (PHH) TG-GATEs dataset. The 398 gene co-expression networks (modules) were annotated with functional information (pathway enrichment, transcription factor) to reveal their mechanistic interpretation. Several well-known stress response pathways were captured in the modules, were perturbed by specific stressors and showed preservation in rat systems (rat primary hepatocytes and rat in vivo liver), with the exception of DNA damage and oxidative stress responses. A subset of 87 well-annotated and preserved modules was used to evaluate mechanisms of toxicity of endoplasmic reticulum (ER) stress and oxidative stress inducers, including cyclosporine A, tunicamycin and acetaminophen. In addition, module responses can be calculated from external datasets obtained with different hepatocyte cells and platforms, including targeted RNA-seq data, therefore, imputing biological responses from a limited gene set. As another application, donors’ sensitivity towards tunicamycin was investigated with the TXG-MAPr, identifying higher basal level of intrinsic immune response in donors with pre-existing liver pathology. In conclusion, we demonstrated that gene co-expression analysis coupled to an interactive visualization environment, the TXG-MAPr, is a promising approach to achieve mechanistic relevant, cross-species and cross-platform evaluation of toxicogenomic data.

Uitspraken van grote denkers zetten door hun beperkte omvang, verbeeldingskracht en helderheid aan tot nadenken en discussie. Leg in een gezelschap een paar uitspraken op tafel en er ontspint zich een verdiepend gesprek. ‘Klopt die uitspraak wel? Ervaar jij dat nou ook zo? Wat raakt je in deze uitspraak? Is het tegenovergestelde ook waar? Jij zegt dat nu wel, maar …’ De meeste uitspraken in 3000 jaar denkers over onderwijs zijn juweeltjes en ze zijn vaak ook nog verrassend actueel. Het euvel van het ontbreken van de bredere context van uitspraken is van minder belang. Deze valt makkelijk te achterhalen via het internet en boeken van de geciteerde denkers. Belangrijker is wat de lezer ermee doet. Met bijdrage van Mariëtte Lusse: Hoofdstuk 5 Over Ouders.

Uitspraken van grote denkers zetten door hun beperkte omvang, verbeeldingskracht en helderheid aan tot nadenken en discussie. Leg in een gezelschap een paar uitspraken op tafel en er ontspint zich een verdiepend gesprek. ‘Klopt die uitspraak wel? Ervaar jij dat nou ook zo? Wat raakt je in deze uitspraak? Is het tegenovergestelde ook waar? Jij zegt dat nu wel, maar …’ De meeste uitspraken in 3000 jaar denkers over onderwijs zijn juweeltjes en ze zijn vaak ook nog verrassend actueel. Het euvel van het ontbreken van de bredere context van uitspraken is van minder belang. Deze valt makkelijk te achterhalen via het internet en boeken van de geciteerde denkers. Belangrijker is wat de lezer ermee doet. Met bijdrage van Mariëtte Lusse: Hoofdstuk 5 Over Ouders.

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1650213%5DMICH-V-1650213, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1650213/MICH-V-1650213/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-307328%5DMICH-F-307328_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/307328/MICH-F-307328_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-307328%5DMICH-F-307328, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/307328/MICH-F-307328/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-126556%5DMICH-F-126556, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/126556/MICH-F-126556/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-127091%5DMICH-F-127091, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/127091/MICH-F-127091/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-121844%5DMICH-F-121844, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/121844/MICH-F-121844/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-127091%5DMICH-F-127091, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/127091/MICH-F-127091/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-126556%5DMICH-F-126556, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/126556/MICH-F-126556/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-121844%5DMICH-F-121844, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/121844/MICH-F-121844/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1583698%5DMICH-V-1583698, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1583698/MICH-V-1583698/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1650226%5DMICH-V-1650226, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1650226/MICH-V-1650226/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Bryophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-687538%5DMICH-B-687538, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/687538/MICH-B-687538/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Bryophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-606825%5DMICH-B-606825, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/606825/MICH-B-606825/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Bryophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-574654%5DMICH-B-574654, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/574654/MICH-B-574654/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1583619%5DMICH-V-1583619, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1583619/MICH-V-1583619/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1583532%5DMICH-V-1583532, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1583532/MICH-V-1583532/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1583526%5DMICH-V-1583526, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1583526/MICH-V-1583526/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1599500%5DMICH-V-1599500, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1599500/MICH-V-1599500/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1583698%5DMICH-V-1583698, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1583698/MICH-V-1583698/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1650226%5DMICH-V-1650226, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1650226/MICH-V-1650226/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-127091%5DMICH-F-127091, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/127091/MICH-F-127091/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Lichens, http://name.umdl.umich.edu/IC-HERB00IC-X-121844%5DMICH-F-121844, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/121844/MICH-F-121844/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Bryophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-687538%5DMICH-B-687538, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/687538/MICH-B-687538/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Bryophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-574654%5DMICH-B-574654, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/574654/MICH-B-574654/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1711812%5DMICH-V-1711812, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1711812/MICH-V-1711812/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-313722%5DMICH-F-313722_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/313722/MICH-F-313722_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311435%5DMICH-F-311435, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311435/MICH-F-311435/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311440%5DMICH-F-311440, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311440/MICH-F-311440/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311442%5DMICH-F-311442_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311442/MICH-F-311442_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311492%5DMICH-F-311492, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311492/MICH-F-311492/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311468%5DMICH-F-311468, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311468/MICH-F-311468/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311432%5DMICH-F-311432, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311432/MICH-F-311432/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311442%5DMICH-F-311442, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311442/MICH-F-311442/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311445%5DMICH-F-311445, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311445/MICH-F-311445/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311434%5DMICH-F-311434, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311434/MICH-F-311434/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311338%5DMICH-F-311338, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311338/MICH-F-311338/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-312202%5DMICH-F-312202, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/312202/MICH-F-312202/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311398%5DMICH-F-311398, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311398/MICH-F-311398/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311400%5DMICH-F-311400, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311400/MICH-F-311400/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311491%5DMICH-F-311491, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311491/MICH-F-311491/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311338%5DMICH-F-311338_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311338/MICH-F-311338_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Fungi, http://name.umdl.umich.edu/IC-HERB00IC-X-311468%5DMICH-F-311468_1, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/311468/MICH-F-311468_1/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy