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Detecting sputum pyocyanin (PYO) with a competitive immunoassay is a promising approach for diagnosing Pseudomonas aeruginosa respiratory infections. However, it is not possible to perform a negative control to evaluate matrix-effects in competitive immunoassays, and the highly complex sputum matrix often interferes with target detection. Here, we show that these issues are alleviated by performing competitive immunoassays with a paper biosensor. The biosensing platform consists of a paper reservoir, which contains antibody-coated gold nanoparticles, and a substrate containing a competing recognition element, which is a piece of paper modified with an albumin-antigen conjugate. Detection of PYO with a limit of detection of 4.7·10-3 µM and a dynamic range between 4.7·10-1 µM and 47.6 µM is accomplished by adding the sample to the substrate with the competing element and pressing the reservoir against it for 5 min. When tested with patient samples, the biosensor was able to qualitatively differentiate spiked from non-spiked samples, whereas ELISA did not show a clear cut-off between them. Furthermore, the relative standard deviation was lower when determining sputum with the paper-based biosensor. These features, along with a mild liquefaction step that circumvents the use of harsh chemicals or instruments, make our biosensor a good candidate for diagnosing Pseudomonas infections at the bedside through the detection of sputum PYO.

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF-CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF-CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF-CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF-CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF-CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF-CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF-CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF-CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF-CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF-CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF-CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF-CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF-CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF-CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF-CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF-CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofibril (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF-CoFe2O4). Besides imparting magnetization and magnetostriction, the incorporation of CoFe2O4 particles decreased the ultimate tensile strength and increased the fracture elongation of the CNF-CoFe2O4 composite paper. CNF was responsible for the tensile properties of CNF-CoFe2O4 composite paper. Consequently, the magnetic and magnetostrictive properties and tensile properties of CNF-CoFe2O4 composite paper can be controlled by changing the mixture ratio of CNF and CoFe2O4 particles.

Light-weight paper products that contain less fibres, but with a maintained bulk and improved strength properties, are highly desirable due to the low cost of raw materials and improved logistics of packaged goods. In this respect, the adsorption capacity of dry strength additives onto fibres, which is affected by the surface charge of said fibres, is very important for the development of these mechanically robust paper products. The influence of the surface charge on the adsorption of strength additives was investigated for, dissolving grade fibres, kraft fibres and kraft fibres modified with carboxymethyl cellulose (CMC) with different surface charge densities, but the same fibre dimensions. The strength additives investigated were cationic starch (CS), anionic polyacrylamide (APAM) and polyelectrolyte complexes (PECs), containing CS and APAM. A linear relationship was found between the surface charge of the fibres and the saturated adsorbed amount of CS. However, when either APAM or PECs adsorbed as secondary layers onto the CS, no correlation between cellulose charge and the saturation adsorption could be observed. The adsorption of APAM was dramatically affected by the pre-adsorbed amount of CS, whereas PECs were less influenced. Moreover, the additives improved the tensile strength (60%) and strain at break (> 100%) of handsheets formed with the kraft fibres and adsorbed APAM. It was also found that CS/APAM increased the sheet density while CS/PECs lowered it. In conclusion, the gained fundamental understanding of these adsorption of additives is of significant importance to facilitate the industrial development of sustainable low-cost high-end packaging products. Graphical abstract: [Figure not available: see fulltext.], QC 20221027

Pulp refining is an essential process step prior to paper production. The contribution of fines production during refining to the resulting paper strength so far has mostly been considered qualitatively. A quantitative and experimental evaluation regarding their effect has not yet been published. Unbleached softwood kraft pulp was refined using a PFI mill and a disc refiner at different refining intensities. Prior to handsheet forming, fines were removed in a lab scale pressure screen from one part of the refined and unrefined samples in order to investigate the difference in tensile strength between sheets with and without fines, which were furthermore produced with and without additional wet pressing. It was found, that fines formed in a disc refiner at 250 kWh/t are responsible for up to 25% of the breaking length increase, while the PFI mill at 10,000 revolutions fines only contribute to a maximum of 12%. In terms of fines efficiency, the disc refiner was able to achieve higher results compared to the PFI mill, which however might be attributed to the higher fibre flexibilization in the PFI mill. Thus fines formed in the refining process are of high importance for strength development especially for the disc refiner., QC 20230523

This paper aims to understand complex social events that arise when communicating general concepts in the digital space. Today, we get informed through many different channels, at different times of the day, in different contexts, and on many different devices. In addition to that, more complexity is added by the bidirectional nature of the communication itself. People today react very quickly to specific topics through various means such as rating, sharing, commenting, tagging, icons, tweeting, etc. Such activities generate additional metadata to the information itself which become part of the original message. When planning proper communication we should consider all this. In such a complicated environment, the likelihood of a message's real meaning being received in a distorted or confused way is very high. However, as we have seen recently during the Covid-19 pandemic, at times, there is the need to communicate something, somewhat complicated in nature, while we need to make sure citizens fully understand the actual terms and meaning of the communication. This was the case faced by many governments worldwide when informing their population on the rules of conduct during the various lockdown periods. We analyzed trends and structure of social network data generated as a reaction to those official communications in Italy. Our goal is to derive a model to estimate whether the communication intended by the government was properly understood by the large population. We discovered some regularities in social media generated data related to "poorly" communicated issues. We believe it is possible to derive a model to measure how well the recipients grasp a specific topic. And this can be used to trigger real-time alerts when the need for clarification arises., QC 20220408Part of proceedings: ISBN 978-3-030-95470-3; 978-3-030-95469-7

Double-roll compaction is a process to create extensible paper and paperboard suitable for replacing plastic in 3D forming applications. Understanding the macro- and micro-mechanisms governing the compaction process allows increasing the stretch potential while maintaining sufficient strength and bending stiffness. In this work, we approach the compaction process of paperboard with micro-mechanical methods featuring the unprecedented level of details otherwise inaccessible with currently available experimental tools. The loading scheme is based on experiments and continuum level simulations. The different levels of compaction and their continuous impact on the fibers’ geometry, void closures, and irreversible deformation of the fibers are thoroughly characterized. We find that the structural changes are concentrated in the fibers oriented within 30 degrees of the direction of compaction. The deformation accumulates primarily in the wall of the fibers in the form of irreversible strains. The spring-back effect beyond the compaction is negligible. For the first time, the role of normal and frictional fiber-to-fiber interactions in the compaction process is investigated and quantified. The frictional interaction between the fibers has a surprisingly low impact on the outcome of the compaction process, and the normal interaction between the fibers has a dominant response. The consequence of this finding is potentially limited impact of the surface modifications targeting the friction., QC 20220331

Purpose of Review: Osteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure. Recent Findings: This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. Summary: The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.

Cellulose fibers are a major industrial input, but due to their irregular shape and anisotropic material response, accurate material characterization is difficult. Single fiber tensile testing is the most popular way to estimate the material properties of individual fibers. However, such tests can only be performed along the axis of the fiber and are associated with problems of enforcing restraints. Alternative indirect approaches, such as micro-mechanical modeling, can help but yield results that are not fully decoupled from the model assumptions. Here, we compare these methods with nanoindentation as a method to extract elastic material constants of the individual fibers. We show that both the longitudinal and the transverse elastic modulus can be determined, additionally enabling the measurement of fiber properties in-situ inside a sheet of paper such that the entire industrial process history is captured. The obtained longitudinal modulus is comparable to traditional methods for larger indents but with a strongly increased scatter as the size of the indentation is decreased further., QC 20220214Not duplicate with DiVa 1585095

This paper examines the personal and professional experiences of the five arts leaders who co-wrote the foundation document for Australia’s first national curriculum in the Arts. Their personal and professional backgrounds, which were explored during in depth interviews, drove the complex collaborative process that informed the first iteration of the Australian Curriculum: The Arts. Though each couched their responses in the context of their background and arts discipline, they shared an awareness of the important role of the Arts in providing the analytical tools for children and young people to identify and subsequently challenge social injustice. The findings, which are presented as a group narrative using a Narrative Inquiry approach, reveal how the five arts leaders’ individual lived experience, disciplinary experience and expertise, and commitment to collaborative leadership informed their approach. It was one driven by their shared belief that all Australian students, regardless of their background, are entitled to a quality arts education.

Tissue paper softness relies on two major factors, the bulk softness, which can be indicated by the elasticity of the sheet, and surface softness. Measurement of surface softness is complicated and often requires a multi-step process. A key parameter defining surface softness is the topography of the surface, particularly the crepe structure and its periodicity. Herein, we present a novel approach to measure and quantify the tissue paper surface crepe structure and periodicity based on the detection of waviness along the sample using laser scanning confocal microscopy (LSM) and X-ray tomography (XRT). In addition, field emission scanning electron microscope (FESEM) was used to characterize the tissue paper surface. We demonstrate that surface topography is directly correlated to the erosion of the doctor blade, which is used to remove the dry tissue paper from the Yankee cylinder. Because of its accuracy and simplicity, the laser confocal microscopy method has the potential to be used directly on the production line to monitor the production process of the tissue paper. XRT revealed more structural details of the tissue paper structure in 3D, and it allowed for the reconstruction of the surface and the internal structure of the tissue paper.

Background A central construct in Schema Therapy (ST) is that of a schema mode, describing the current emotional-cognitive-behavioral state. Initially, 10 modes were described. Over time, with the world-wide increasing and broader application of ST to various disorders, additional schema modes were identified, mainly based on clinical impressions. Thus, the need for a new, theoretically based, cross-cultural taxonomy of modes emerged. Methods An international workgroup started from scratch to identify an extensive taxonomy of modes, based on (a) extending the theory underlying ST with new insights on needs, and (b) recent research on ST theory supporting that modes represent combinations of activated schemas and coping. Results We propose to add two emotional needs to the original five core needs that theoretically underpin the development of early maladaptive schemas (EMSs), i.e., the need for Self-Coherence, and the need for Fairness, leading to three new EMSs, i.e. Lack of a Coherent Identity, Lack of a Meaningful World, and Unfairness. When rethinking the purpose behind the different ways of coping with EMS-activation, we came up with new labels for two of those: Resignation instead of Surrender, and Inversion instead of Overcompensation. By systematically combining EMSs and ways of coping we derived a set of schema modes that can be empirically tested. Conclusions With this project, we hope to contribute to the further development of ST and its application across the world.

There is now a wide agreement that reforms of the architecture of the Eurozone (EZ) are needed, reforms aimed at fostering further integration of economic policy and governance. Behind the plea for “more Europe”, divergences loom large across member states. The cleavage is normally represented in geographic mode, the Northern EZ countries (NEZ) on one side, the Southern EZ countries (SEZ) on the other. It is quite clear that divergences have more to do with economy and polity than with geography. Suspicion runs high and mutual trust runs low between SEZ and NEZ. In these circumstances, it is extremely difficult to reform the EZ, while the conditions are set for populist, sovereigntist, anti-European movements to thrive. However the COVID pandemic may turn out to be a catalyst of reforms. We first attempt at understanding the legacy of the EZ crisis of the 2010s and its mismanagement by appealing to the present “consensus view”. This effort will help the reader focusing on why NEZ and SEZ disagree and to find out whether and how they can agree. Second, we try to build on this common narrative in order to identify the possible consensus changes in the EZ rules and institutions.

Background A central construct in Schema Therapy (ST) is that of a schema mode, describing the current emotional-cognitive-behavioral state. Initially, 10 modes were described. Over time, with the world-wide increasing and broader application of ST to various disorders, additional schema modes were identified, mainly based on clinical impressions. Thus, the need for a new, theoretically based, cross-cultural taxonomy of modes emerged. Methods An international workgroup started from scratch to identify an extensive taxonomy of modes, based on (a) extending the theory underlying ST with new insights on needs, and (b) recent research on ST theory supporting that modes represent combinations of activated schemas and coping. Results We propose to add two emotional needs to the original five core needs that theoretically underpin the development of early maladaptive schemas (EMSs), i.e., the need for Self-Coherence, and the need for Fairness, leading to three new EMSs, i.e. Lack of a Coherent Identity, Lack of a Meaningful World, and Unfairness. When rethinking the purpose behind the different ways of coping with EMS-activation, we came up with new labels for two of those: Resignation instead of Surrender, and Inversion instead of Overcompensation. By systematically combining EMSs and ways of coping we derived a set of schema modes that can be empirically tested. Conclusions With this project, we hope to contribute to the further development of ST and its application across the world.

Background: Information about airborne pollen concentrations is required by a range of end users, particularly from the health sector who use both observations and forecasts to diagnose and treat allergic patients. Manual methods are the standard for such measurements but, despite the range of pollen taxa that can be identified, these techniques suffer from a range of drawbacks. This includes being available at low temporal resolution (usually daily averages) and with a delay (usually 3–9 days from the measurement). Recent technological developments have made possible automatic pollen measurements, which are available at high temporal resolution and in real time, although currently only scattered in a few locations across Europe. Materials & Methods: To promote the development of an extensive network across Europe and to ensure that this network will respond to end user needs, a stakeholder workshop was organised under the auspices of the EUMETNET AutoPollen Programme. Participants discussed requirements for the groups they represented, ranging from the need for information at various spatial scales, at high temporal resolution, and for targeted services to be developed. Results: The provision of real-time information is likely to lead to a notable decrease in the direct and indirect health costs associated with allergy in Europe, currently estimated between €50–150 billion/year.1 Discussion & Conclusion: A European measurement network to meet end user requirements would thus more than pay for itself in terms of potential annual savings and provide significant impetus to research across a range of disciplines from climate science and public health to agriculture and environmental management., Peer Reviewed, Postprint (published version)

Chimeric antigen receptor (CAR) T-cell therapy is one of the most promising emerging treatments for B-cell malignancies. Recently, two CAR T-cell products (axicabtagene ciloleucel and tisagenlecleucel) have been approved for patients with aggressive B-cell lymphoma and acute lymphoblastic leukemia; many other CAR-T constructs are in research for both hematological and non-hematological diseases. Most of the patients receiving CAR-T therapy will develop fever at some point after infusion, mainly due to cytokine release syndrome (CRS). The onset of CRS is often indistinguishable from an infection, which makes management of these patients challenging. In addition to the lymphodepleting chemotherapy and CAR T cells, the treatment of complications with corticosteroids and/or tocilizumab increases the risk of infection in these patients. Data regarding incidence, risk factors and prevention of infections in patients receiving CAR-T cell therapy are scarce. To assist in patient care, a multidisciplinary team from hospitals designated by the Spanish Ministry of Health to perform CAR-T therapy prepared these recommendations. We reviewed the literature on the incidence, risk factors, and management of infections in adult and pediatric patients receiving CAR-T cell treatment. Recommendations cover different areas: monitoring and treatment of hypogammaglobulinemia, prevention, prophylaxis, and management of bacterial, viral, and fungal infections as well as vaccination prior and after CAR-T cell therapy.

The International Conference on Agile Software Development (XP) was established almost sixteen years ago. Based on data from Scopus database, a total of 789 papers have been published in between years of 2002 and 2018. We employed bibliometrics analysis and topic modeling with R/RStudio to analyze these published papers from various dimensions, including the most active authors, collaboration of authorship, most cited papers, used keywords and trends of probable topics from the titles and abstracts of those papers. The results show that the first five years of XP conference cover nearly 40% of the papers published until now and almost 62% of the XP papers have been cited at least once. Mining of XP conference paper titles and abstracts result in these hot research topics: “Coordination”, “Technical Debt”, “Teamwork”, “Startups” and “Agile Practices”, thus strongly focusing on practical issues and problems faced by the practitioners in the industry. The results highlight the most influential researchers and institutions, and the collaboration between the authors in the conference papers. The approach applied in this study can be extended to other software engineering venues and can be applied to large-scale studies.