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This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.

Between the more established media ‘epochs’ of mechanical drafting, on the one hand, and computerization on the other, there exists a short but decisive period during which architectural production was technologized in new and understudied ways. An array of graphic ‘supplies’ found their way onto the architects working surface, from the draftsman’s table to the principal’s desk. These supplies, neither instruments nor tools, were the temporal, replaceable and refillable items that joined the many other machines that came to typify the office landscape. Despite a growing literature on the architect’s toolkit, the graphic supplies chain of the postwar office remain overlooked because of their ephemerality and often gizmo scale. As such their omission risks maintaining the historical binaries between conceptual designers and technicians and autonomous and bureaucratic architectures, intrinsic to the introduction of computation. In order to refute these false oppositions and fill the historiographical gap they have produced I argue that the architect’s desk in this period must be recognized as a technologized theater of production. This dissertation bridges the divide and examines how the toolkit became a theoretical problem of authorship, shaped by the longer distinctions between models of authorship and anonymity. Rather than focus on one to the exclusion of the other, this dissertation looks in between, and simultaneously examines one of the most formidably entrenched models of authorship of the period, the one constructed by Peter Eisenman, but also the great network of anonymous supplies, actions, and agents with which he is never associated. The dissertation reveals multiple points of contact between architectural drawing practices and a previously unrecognized network of material research laboratories, tool manufacturers and distributors, trade journals and advertising. Not only were these supplies intrinsic to the development and organization of the bureaucratic

Providing effective healthcare to underrepresented populations is a major challenge worldwide due to environmental, economic, and social disparities. Both developing countries and low income rural/urban areas in the US tend to have reduced healthcare access which limits the frequency and quality of medical screenings as well as treatment options. This has led to an increased effort in the development of point-of-care devices which emphasize, immediate and onsite results. One device that has the potential to fulfill these requirements is the lateral-flow immunoassay (LFA). While the LFA has been successful in the form of the over-the-counter pregnancy test, it still does have some disadvantages that limit its ability to fully replace sophisticated laboratory-based assays. Throughout this thesis, I will be discussing the development of cutting-edge technologies to address the two major disadvantages of the LFA which are its poor quantitative characteristics and low sensitivity.Cerebrospinal fluid (CSF) leaks are a common complication of numerous procedures in Otolaryngology. These leaks are relatively difficult to diagnose and the current laboratory-based tests to do so have a turn-around time that is unacceptable for rapid clinical decision making. We addressed this problem by developing the first rapid diagnostic test kit for the detection of CSF leaks. In Chapter 2, we describe the development of a barcode-style LFA for the semi-quantitative detection of beta-trace protein, which is present in CSF at high concentrations. This work was expanded upon in Chapter 3, where we created a complete, standalone rapid diagnostic test kit composed of our barcode-style LFA, a collection swab, dilution buffers, disposable pipettes, and instructions. Clinical studies demonstrated excellent predictive capabilities of this kit in distinguishing patient samples containing CSF from those that did not. In some cases, a more quantitative readout than what the barcode-style LFA can achi

This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series of questions of specific interest to surgeons taking care of patients with pancreatic neuroendocrine tumors, and for each, the available literature was reviewed. What follows are these reviews for each question followed by recommendations of the panel.

How, and how effectively, different electric vehicle (EV) related policies will work is an immediate and important question for California as the state updates its EV policies. Adding urgency, Assembly Bill (AB) 615, which was signed by the Governor, requires the California Air Resources Board (CARB) to produce a report by December 2018 on related topics, in consultation with the University of California Institute of Transportation Studies (UC ITS). Senate Bill (SB) 498, also signed, also requires CARB reporting with somewhat different but overlapping topics. The need is to define the state of the research on policies to support EV deployment in a manner that is directly usable by California in updating policies. The specific need for CARB is material estimates of these factors (called out in AB 615): "impact of income caps, increased rebates for low-income consumers, and increased outreach on the electric vehicle market, as well as a quantification of emissions reductions attributable to the Clean Vehicle Rebate Project."This white paper is one in a series summarizing recent research findings for the state of California. The topic of the series is evaluating the important components of electric vehicle adoption and its effects. The goals of these white papers are to: 1. Synthesize the best published and on-going research available on each topic; 2. Highlight important research gaps and propose areas for future research; 3. Provide the reader with a framework for understanding the various dimensions of each topic; 4. Make a clear link between research findings and policy implications, if possible; and 5. Be accessible to an informed and interested, but non-technical audience.

Paper microfluidic devices (including lateral flow assays) offer an excellent combination of utility and low cost. Many paper microfluidic devices are fabricated using the Xerox ColorQube line of commercial wax-based color printers; the wax ink serves as a hydrophobic barrier to fluid flow. These printers are capable of depositing four different colors of ink, cyan (C), magenta (M), yellow (Y), and black (K), plus 11 combinations of these colors (CM, CY, CK, MY, MK, YK, CMY, CMK, CYK, MYK, and CMYK), although most researchers use only black ink to print paper microfluidic devices. Recently, as part of a project to develop a computer-aided design framework for use with paper microfluidics devices, we unexpectedly observed that different colors of wax ink behave differently in paper microfluidics. We found that among the single colors of ink, black ink actually had the most barrier failures, and magenta ink had the fewest barrier failures. In addition, some combinations of colors performed even better than magenta: the combinations CY, MK, YK, CMY, CYK and MYK had no barrier failures in our study. We also found that the printer delivers significantly different amounts of ink to the paper for the different color combinations, and in general, the color combinations that formed the strongest barriers to fluid flow were the ones that had the most ink delivered to the paper. This suggests that by simply weighing paper samples printed with all 15 combinations of colors, one can easily find the color combinations most likely to form a strong barrier for a given printer. Finally, to show that deliberate choices of ink colors can actually be used to create new functions in paper microfluidics, we designed and tested a new color-based "antifuse" structure that protects paper microfluidic devices from a typical operator error (addition of too much fluid to the device). Our results provide a set of color choice guidelines that designers can use to control the behavior of their pa

The use of misidentified and contaminated cell lines continues to be a problem in biomedical research. Research Resource Identifiers (RRIDs) should reduce the prevalence of misidentified and contaminated cell lines in the literature by alerting researchers to cell lines that are on the list of problematic cell lines, which is maintained by the International Cell Line Authentication Committee (ICLAC) and the Cellosaurus database. To test this assertion, we text-mined the methods sections of about two million papers in PubMed Central, identifying 305,161 unique cell-line names in 150,459 articles. We estimate that 8.6% of these cell lines were on the list of problematic cell lines, whereas only 3.3% of the cell lines in the 634 papers that included RRIDs were on the problematic list. This suggests that the use of RRIDs is associated with a lower reported use of problematic cell lines.

The purpose of this white paper is to provide Caltrans with a methodology that uses LCA and LCCA analyses to create a “supply curve” that ranks the different strategies/actions that can be taken to reduce GHG emissions and lessen any other environmental impacts that affect ecosystems and human health. For Caltrans to implement the proposed methodology, the process must be validated and assessed using currently available actions. This white paper presents the methodology and demonstrates its initial use in quantifying and ranking several potential strategies.

This paper explores one reason for the educational gaps experienced by Black men. Using variation in state marijuana possession and distribution laws, this paper examines whether the Anti-Drug Act of 1986, which increased the disproportionate incarceration of Black males, also led to differences in college enrollment rates. The results suggest that Black males had a 2.2% point decrease in the relative probability of college enrollment after the passage of the Anti-Drug Abuse Act of 1986. There is some evidence that laws around crack cocaine, and not marijuana, led to this decrease in the probability of enrollment.

How, and how effectively, different electric vehicle (EV) related policies will work is an immediate and important question for California as the state updates its EV policies. Adding urgency, Assembly Bill (AB) 615, which was signed by the Governor, requires the California Air Resources Board (CARB) to produce a report by December 2018 on related topics, in consultation with the University of California Institute of Transportation Studies (UC ITS). Senate Bill (SB) 498, also signed, also requires CARB reporting with somewhat different but overlapping topics. The need is to define the state of the research on policies to support EV deployment in a manner that is directly usable by California in updating policies. The specific need for CARB is material estimates of these factors (called out in AB 615): "impact of income caps, increased rebates for low-income consumers, and increased outreach on the electric vehicle market, as well as a quantification of emissions reductions attributable to the Clean Vehicle Rebate Project."This white paper is one in a series summarizing recent research findings for the state of California. The topic of the series is evaluating the important components of electric vehicle adoption and its effects. The goals of these white papers are to: 1. Synthesize the best published and on-going research available on each topic; 2. Highlight important research gaps and propose areas for future research; 3. Provide the reader with a framework for understanding the various dimensions of each topic; 4. Make a clear link between research findings and policy implications, if possible; and 5. Be accessible to an informed and interested, but non-technical audience.

Paper microfluidic devices (including lateral flow assays) offer an excellent combination of utility and low cost. Many paper microfluidic devices are fabricated using the Xerox ColorQube line of commercial wax-based color printers; the wax ink serves as a hydrophobic barrier to fluid flow. These printers are capable of depositing four different colors of ink, cyan (C), magenta (M), yellow (Y), and black (K), plus 11 combinations of these colors (CM, CY, CK, MY, MK, YK, CMY, CMK, CYK, MYK, and CMYK), although most researchers use only black ink to print paper microfluidic devices. Recently, as part of a project to develop a computer-aided design framework for use with paper microfluidics devices, we unexpectedly observed that different colors of wax ink behave differently in paper microfluidics. We found that among the single colors of ink, black ink actually had the most barrier failures, and magenta ink had the fewest barrier failures. In addition, some combinations of colors performed even better than magenta: the combinations CY, MK, YK, CMY, CYK and MYK had no barrier failures in our study. We also found that the printer delivers significantly different amounts of ink to the paper for the different color combinations, and in general, the color combinations that formed the strongest barriers to fluid flow were the ones that had the most ink delivered to the paper. This suggests that by simply weighing paper samples printed with all 15 combinations of colors, one can easily find the color combinations most likely to form a strong barrier for a given printer. Finally, to show that deliberate choices of ink colors can actually be used to create new functions in paper microfluidics, we designed and tested a new color-based "antifuse" structure that protects paper microfluidic devices from a typical operator error (addition of too much fluid to the device). Our results provide a set of color choice guidelines that designers can use to control the behavior of their pa

The purpose of this white paper is to provide Caltrans with a methodology that uses LCA and LCCA analyses to create a “supply curve” that ranks the different strategies/actions that can be taken to reduce GHG emissions and lessen any other environmental impacts that affect ecosystems and human health. For Caltrans to implement the proposed methodology, the process must be validated and assessed using currently available actions. This white paper presents the methodology and demonstrates its initial use in quantifying and ranking several potential strategies.

This paper explores one reason for the educational gaps experienced by Black men. Using variation in state marijuana possession and distribution laws, this paper examines whether the Anti-Drug Act of 1986, which increased the disproportionate incarceration of Black males, also led to differences in college enrollment rates. The results suggest that Black males had a 2.2% point decrease in the relative probability of college enrollment after the passage of the Anti-Drug Abuse Act of 1986. There is some evidence that laws around crack cocaine, and not marijuana, led to this decrease in the probability of enrollment.

The use of misidentified and contaminated cell lines continues to be a problem in biomedical research. Research Resource Identifiers (RRIDs) should reduce the prevalence of misidentified and contaminated cell lines in the literature by alerting researchers to cell lines that are on the list of problematic cell lines, which is maintained by the International Cell Line Authentication Committee (ICLAC) and the Cellosaurus database. To test this assertion, we text-mined the methods sections of about two million papers in PubMed Central, identifying 305,161 unique cell-line names in 150,459 articles. We estimate that 8.6% of these cell lines were on the list of problematic cell lines, whereas only 3.3% of the cell lines in the 634 papers that included RRIDs were on the problematic list. This suggests that the use of RRIDs is associated with a lower reported use of problematic cell lines.

PURPOSE:To assess time requirements for patient encounters and estimate after-hours demands of paper-based clinical workflows in ophthalmology. DESIGN:Time-and-motion study with a structured survey. METHODS:This study was conducted in a single academic ophthalmology department. A convenience sample consisted of 7 attending ophthalmologists from 6 subspecialties observed during 414 patient encounters for the time-motion analysis and 12 attending ophthalmologists for the survey. Outcome measurements consisted of total time spent by attending ophthalmologists per patient and time spent on documentation, examination, and talking with patients. The survey assessed time requirements of documentation-related activities performed outside of scheduled clinic hours. RESULTS:Among the 7 attending ophthalmologists observed (6 men and 1 woman), mean ± SD age 43.9 ± 7.1 years, during encounters with 414 patients (57.8 ± 24.6 years of age), total time spent per patient was 8.1 ± 4.8 minutes, with 2.8 ± 1.4 minutes (38%) for documentation, 1.2 ± 0.9 minutes (17%) for examination, and 3.3 ± 3.1 minutes (37%) for talking with patients. New patient evaluations required significantly more time than routine follow-up visits and postoperative visits. Higher clinical volumes were associated with less time per patient. Survey results indicated that paper-based documentation was associated with minimal after-hours work on weeknights and weekends. CONCLUSIONS:Paper-based documentation takes up a substantial portion of the total time spent for patient care in outpatient ophthalmology clinics but is associated with minimal after-hours work. Understanding paper-based clinical workflows may help inform targeted strategies for improving electronic health record use in ophthalmology.

We argue that it is essential that the Astro2020 survey of the present state of American astronomy and the recommendations for the next decade address the issue of ensuring preservation of, and making more discoverable and accessible, the field’s rich legacy materials. These include both archived observations of scientific value and items of historical importance. Much of this heritage likely will be lost if action is not taken in the next decade. It is proposed that the decadal plan include recommendations on (1) compiling a list of historic sites and development of models for their preservation, (2) carrying out a comprehensive inventory of astronomy’s archival material, and (3) digitizing, with web-based publication, those photographs and papers judged to have the most value for scientific and historical investigations. The estimated cost for an example project on plate preservation is a one-time investment of less than $10 million over ten years plus the typical on-going costs to maintain and manage a medium sized database.

In response to the need for the Astro2020 Decadal Survey to explicitly engage early career astronomers, the National Academies of Sciences, Engineering, and Medicine hosted the Early Career Astronomer and Astrophysicist Focus Session (ECFS) on October 8-9, 2018 under the auspices of Committee of Astronomy and Astrophysics. The meeting was attended by fifty six pre-tenure faculty, research scientists, postdoctoral scholars, and senior graduate students, as well as eight former decadal survey committee members, who acted as facilitators. The event was designed to educate early career astronomers about the decadal survey process, to solicit their feedback on the role that early career astronomers should play in Astro2020, and to provide a forum for the discussion of a wide range of topics regarding the astrophysics career path. This white paper presents highlights and themes that emerged during two days of discussion. In Section 1, we discuss concerns that emerged regarding the coming decade and the astrophysics career path, as well as specific recommendations from participants regarding how to address them. We have organized these concerns and suggestions into five broad themes. These include (sequentially): (1) adequately training astronomers in the statistical and computational techniques necessary in an era of "big data", (2) responses to the growth of collaborations and telescopes, (3) concerns about the adequacy of graduate and postdoctoral training, (4) the need for improvements in equity and inclusion in astronomy, and (5) smoothing and facilitating transitions between early career stages. Section 2 is focused on ideas regarding the decadal survey itself, including: incorporating early career voices, ensuring diverse input from a variety of stakeholders, and successfully and broadly disseminating the results of the survey.

The past two decades have seen a tremendous investment in observational facilities that promise to reveal new and unprecedented discoveries about the universe. In comparison, the investment in theoretical work is completely dwarfed, even though theory plays a crucial role in the interpretation of these observations, predicting new types of phenomena, and informing observing strategies. In this white paper, we argue that in order to reach the promised critical breakthroughs in astrophysics over the next decade and well beyond, the national agencies must take a serious approach to investment in theoretical astrophysics research. We discuss the role of theory in shaping our understanding of the universe, and then we provide a multi-level strategy, from the grassroots to the national, to address the current underinvestment in theory relative to observational work.

We have compelling evidence for stellar-mass black holes (BHs) of ~5-80 M_sun that form through the death of massive stars. We also have compelling evidence for so-called supermassive BHs (10^5-10^10 M_sun) that are predominantly found in the centers of galaxies. We have very good reason to believe there must be BHs with masses in the gap between these ranges: the first ~10^9 M_sun BHs are observed only hundreds of millions of years after the Big Bang, and all theoretically viable paths to making supermassive BHs require a stage of "intermediate" mass. However, no BHs have yet been reliably detected in the 100-10}^5 M_sun mass range. Uncovering these intermediate-mass BHs of 10^3-10^5 M_sun is within reach in the coming decade. In this white paper we highlight the crucial role that 30-m class telescopes will play in dynamically detecting intermediate-mass black holes, should they exist.

Declining labor force participation rates among less-educated individuals in the U.S. have been attributed to various causes, including skill-biased technical change, demand shocks induced by international competition, looser eligibility requirements for disability insurance, the opioid epidemic and the nature of child care and family leave policies. In this paper, we examine how the labor supply of parents of dependent children respond to minimum wage changes. We implement an event study framework and document a sharp rise in employment and earnings of parents after state minimum wage increases. We further show that these effects are concentrated among jobs that pay the minimum wage or slightly higher – high wage employment remains unaffected. Panel models find corresponding drops in welfare receipts, moreover, for single mothers, effects are larger for mothers of preschool age children. The results are consistent with a simple labor supply model in which means-tested transfers and fixed costs of work in the form of paid childcare create barriers to labor market entry for parents of dependent children. Minimum wage increases then enable higher rates of parental labor force participation, resulting in significant reductions in child poverty. We find no evidence of employment crowd-out among non-parents, suggesting potential overall welfare gains from higher minimum wages.

The term sarcopenia was introduced in 1988. The original definition was a "muscle loss" of the appendicular muscle mass in the older people as measured by dual energy x-ray absorptiometry (DXA). In 2010, the definition was altered to be low muscle mass together with low muscle function and this was agreed upon as reported in a number of consensus papers. The Society of Sarcopenia, Cachexia and Wasting Disorders supports the recommendations of more recent consensus conferences, i.e. that rapid screening, such as with the SARC-F questionnaire, should be utilized with a formal diagnosis being made by measuring grip strength or chair stand together with DXA estimation of appendicular muscle mass (indexed for height2). Assessments of the utility of ultrasound and creatine dilution techniques are ongoing. Use of ultrasound may not be easily reproducible. Primary sarcopenia is aging associated (mediated) loss of muscle mass. Secondary sarcopenia (or disease-related sarcopenia) has predominantly focused on loss of muscle mass without the emphasis on muscle function. Diseases that can cause muscle wasting (i.e. secondary sarcopenia) include malignant cancer, COPD, heart failure, and renal failure and others. Management of sarcopenia should consist of resistance exercise in combination with a protein intake of 1 to 1.5 g/kg/day. There is insufficient evidence that vitamin D and anabolic steroids are beneficial. These recommendations apply to both primary (age-related) sarcopenia and secondary (disease related) sarcopenia. Secondary sarcopenia also needs appropriate treatment of the underlying disease. It is important that primary care health professionals become aware of and make the diagnosis of age-related and disease-related sarcopenia. It is important to address the risk factors for sarcopenia, particularly low physical activity and sedentary behavior in the general population, using a life-long approach. There is a need for more clinical research into the appropriate mea

Declining labor force participation rates among less-educated individuals in the U.S. have been attributed to various causes, including skill-biased technical change, demand shocks induced by international competition, looser eligibility requirements for disability insurance, the opioid epidemic and the nature of child care and family leave policies. In this paper, we examine how the labor supply of parents of dependent children respond to minimum wage changes. We implement an event study framework and document a sharp rise in employment and earnings of parents after state minimum wage increases. We further show that these effects are concentrated among jobs that pay the minimum wage or slightly higher – high wage employment remains unaffected. Panel models find corresponding drops in welfare receipts, moreover, for single mothers, effects are larger for mothers of preschool age children. The results are consistent with a simple labor supply model in which means-tested transfers and fixed costs of work in the form of paid childcare create barriers to labor market entry for parents of dependent children. Minimum wage increases then enable higher rates of parental labor force participation, resulting in significant reductions in child poverty. We find no evidence of employment crowd-out among non-parents, suggesting potential overall welfare gains from higher minimum wages.

The past two decades have seen a tremendous investment in observational facilities that promise to reveal new and unprecedented discoveries about the universe. In comparison, the investment in theoretical work is completely dwarfed, even though theory plays a crucial role in the interpretation of these observations, predicting new types of phenomena, and informing observing strategies. In this white paper, we argue that in order to reach the promised critical breakthroughs in astrophysics over the next decade and well beyond, the national agencies must take a serious approach to investment in theoretical astrophysics research. We discuss the role of theory in shaping our understanding of the universe, and then we provide a multi-level strategy, from the grassroots to the national, to address the current underinvestment in theory relative to observational work.

In response to the need for the Astro2020 Decadal Survey to explicitly engage early career astronomers, the National Academies of Sciences, Engineering, and Medicine hosted the Early Career Astronomer and Astrophysicist Focus Session (ECFS) on October 8-9, 2018 under the auspices of Committee of Astronomy and Astrophysics. The meeting was attended by fifty six pre-tenure faculty, research scientists, postdoctoral scholars, and senior graduate students, as well as eight former decadal survey committee members, who acted as facilitators. The event was designed to educate early career astronomers about the decadal survey process, to solicit their feedback on the role that early career astronomers should play in Astro2020, and to provide a forum for the discussion of a wide range of topics regarding the astrophysics career path. This white paper presents highlights and themes that emerged during two days of discussion. In Section 1, we discuss concerns that emerged regarding the coming decade and the astrophysics career path, as well as specific recommendations from participants regarding how to address them. We have organized these concerns and suggestions into five broad themes. These include (sequentially): (1) adequately training astronomers in the statistical and computational techniques necessary in an era of "big data", (2) responses to the growth of collaborations and telescopes, (3) concerns about the adequacy of graduate and postdoctoral training, (4) the need for improvements in equity and inclusion in astronomy, and (5) smoothing and facilitating transitions between early career stages. Section 2 is focused on ideas regarding the decadal survey itself, including: incorporating early career voices, ensuring diverse input from a variety of stakeholders, and successfully and broadly disseminating the results of the survey.

We have compelling evidence for stellar-mass black holes (BHs) of ~5-80 M_sun that form through the death of massive stars. We also have compelling evidence for so-called supermassive BHs (10^5-10^10 M_sun) that are predominantly found in the centers of galaxies. We have very good reason to believe there must be BHs with masses in the gap between these ranges: the first ~10^9 M_sun BHs are observed only hundreds of millions of years after the Big Bang, and all theoretically viable paths to making supermassive BHs require a stage of "intermediate" mass. However, no BHs have yet been reliably detected in the 100-10}^5 M_sun mass range. Uncovering these intermediate-mass BHs of 10^3-10^5 M_sun is within reach in the coming decade. In this white paper we highlight the crucial role that 30-m class telescopes will play in dynamically detecting intermediate-mass black holes, should they exist.

We argue that it is essential that the Astro2020 survey of the present state of American astronomy and the recommendations for the next decade address the issue of ensuring preservation of, and making more discoverable and accessible, the field’s rich legacy materials. These include both archived observations of scientific value and items of historical importance. Much of this heritage likely will be lost if action is not taken in the next decade. It is proposed that the decadal plan include recommendations on (1) compiling a list of historic sites and development of models for their preservation, (2) carrying out a comprehensive inventory of astronomy’s archival material, and (3) digitizing, with web-based publication, those photographs and papers judged to have the most value for scientific and historical investigations. The estimated cost for an example project on plate preservation is a one-time investment of less than $10 million over ten years plus the typical on-going costs to maintain and manage a medium sized database.

The term sarcopenia was introduced in 1988. The original definition was a "muscle loss" of the appendicular muscle mass in the older people as measured by dual energy x-ray absorptiometry (DXA). In 2010, the definition was altered to be low muscle mass together with low muscle function and this was agreed upon as reported in a number of consensus papers. The Society of Sarcopenia, Cachexia and Wasting Disorders supports the recommendations of more recent consensus conferences, i.e. that rapid screening, such as with the SARC-F questionnaire, should be utilized with a formal diagnosis being made by measuring grip strength or chair stand together with DXA estimation of appendicular muscle mass (indexed for height2). Assessments of the utility of ultrasound and creatine dilution techniques are ongoing. Use of ultrasound may not be easily reproducible. Primary sarcopenia is aging associated (mediated) loss of muscle mass. Secondary sarcopenia (or disease-related sarcopenia) has predominantly focused on loss of muscle mass without the emphasis on muscle function. Diseases that can cause muscle wasting (i.e. secondary sarcopenia) include malignant cancer, COPD, heart failure, and renal failure and others. Management of sarcopenia should consist of resistance exercise in combination with a protein intake of 1 to 1.5 g/kg/day. There is insufficient evidence that vitamin D and anabolic steroids are beneficial. These recommendations apply to both primary (age-related) sarcopenia and secondary (disease related) sarcopenia. Secondary sarcopenia also needs appropriate treatment of the underlying disease. It is important that primary care health professionals become aware of and make the diagnosis of age-related and disease-related sarcopenia. It is important to address the risk factors for sarcopenia, particularly low physical activity and sedentary behavior in the general population, using a life-long approach. There is a need for more clinical research into the appropriate mea

Breakthrough invasive fungal infections (IFIs) have emerged as a significant problem in patients receiving systemic antifungals; however, consensus criteria for defining breakthrough IFI are missing. This position paper establishes broadly applicable definitions of breakthrough IFI for clinical research. Representatives of the Mycoses Study Group Education and Research Consortium (MSG-ERC) and the European Confederation of Medical Mycology (ECMM) reviewed the relevant English literature for definitions applied and published through 2018. A draft proposal for definitions was developed and circulated to all members of the two organisations for comment and suggestions. The authors addressed comments received and circulated the updated document for approval. Breakthrough IFI was defined as any IFI occurring during exposure to an antifungal drug, including fungi outside the spectrum of activity of an antifungal. The time of breakthrough IFI was defined as the first attributable clinical sign or symptom, mycological finding or radiological feature. The period defining breakthrough IFI depends on pharmacokinetic properties and extends at least until one dosing interval after drug discontinuation. Persistent IFI describes IFI that is unchanged/stable since treatment initiation with ongoing need for antifungal therapy. It is distinct from refractory IFI, defined as progression of disease and therefore similar to non-response to treatment. Relapsed IFI occurs after treatment and is caused by the same pathogen at the same site, although dissemination can occur. These proposed definitions are intended to support the design of future clinical trials and epidemiological research in clinical mycology, with the ultimate goal of increasing the comparability of clinical trial results.

PURPOSE:Overactive bladder syndrome is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence in the absence of urinary tract infection or another obvious pathological condition. Electronic questionnaires have been used in a few specialties with the hope of improving treatment outcomes and patient satisfaction. However, they have not been widely used in the urological field. When treating overactive bladder, the main outcome is to improve patient quality of life. The primary objective of this study was to evaluate whether electronic questionnaires would be equally accepted as or preferred to paper questionnaires. The secondary objective was to look at the preference in relation to patient age, education and iPad® tablet familiarity. MATERIALS AND METHODS:We prospectively evaluated the iList® electronic questionnaire application using a friendly iPad tablet in patients with overactive bladder who presented to the urology clinic at our institution. Each of the 80 patients who were recruited randomly completed the validated OABSS (Overactive Bladder Symptom Score) and the PPBC (Patient Perception of Bladder Condition) questionnaires in paper and electronic format on the tablet. Variables potentially associated with the outcomes of interest included demographic data, questionnaire method preference, patient response rate and iPad familiarity. We used the 2-sided Z-test to determine whether the proportion of patients who considered the tablet to be the same, better or much better than paper was significantly greater than 50%. The 2-sided chi-square test was applied to assess whether the intervention effect significantly differed among the demographic subgroups. RESULTS:A total of 80 patients 21 to 87 years old were enrolled in the study from November 2015 to August 2016. Of the patients 53% were female and 49% were 65 years or younger. The incidence of those who considered the tablet to be the same or

Several studies have reported on wide-spread contamination of U.S. paper currency with cocaine and to a lesser extent other illicit drugs. Canines are trained and employed to search for and alert to drugs. Canine alert to currency has been used as evidence that currency has been directly involved in illicit drug trafficking to justify currency seizure and forfeiture. This assertion, particularly when the only evidence is based upon canine alert, has been challenged in the courts considering that most currency in circulation is contaminated with cocaine. Comprehensive review of the scientific literature establishes that (i) 67-100% of circulated U.S. currency is contaminated with cocaine ranging from a few nanograms to over one milligram/bill (ii) various biological and environmental parameters impact canine alert to drugs. It is concluded that canine alert to U.S. currency is not sufficiently reliable to determine that currency was directly used in an illicit drug transaction.

Several studies have reported on wide-spread contamination of U.S. paper currency with cocaine and to a lesser extent other illicit drugs. Canines are trained and employed to search for and alert to drugs. Canine alert to currency has been used as evidence that currency has been directly involved in illicit drug trafficking to justify currency seizure and forfeiture. This assertion, particularly when the only evidence is based upon canine alert, has been challenged in the courts considering that most currency in circulation is contaminated with cocaine. Comprehensive review of the scientific literature establishes that (i) 67-100% of circulated U.S. currency is contaminated with cocaine ranging from a few nanograms to over one milligram/bill (ii) various biological and environmental parameters impact canine alert to drugs. It is concluded that canine alert to U.S. currency is not sufficiently reliable to determine that currency was directly used in an illicit drug transaction.

PURPOSE:Overactive bladder syndrome is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence in the absence of urinary tract infection or another obvious pathological condition. Electronic questionnaires have been used in a few specialties with the hope of improving treatment outcomes and patient satisfaction. However, they have not been widely used in the urological field. When treating overactive bladder, the main outcome is to improve patient quality of life. The primary objective of this study was to evaluate whether electronic questionnaires would be equally accepted as or preferred to paper questionnaires. The secondary objective was to look at the preference in relation to patient age, education and iPad® tablet familiarity. MATERIALS AND METHODS:We prospectively evaluated the iList® electronic questionnaire application using a friendly iPad tablet in patients with overactive bladder who presented to the urology clinic at our institution. Each of the 80 patients who were recruited randomly completed the validated OABSS (Overactive Bladder Symptom Score) and the PPBC (Patient Perception of Bladder Condition) questionnaires in paper and electronic format on the tablet. Variables potentially associated with the outcomes of interest included demographic data, questionnaire method preference, patient response rate and iPad familiarity. We used the 2-sided Z-test to determine whether the proportion of patients who considered the tablet to be the same, better or much better than paper was significantly greater than 50%. The 2-sided chi-square test was applied to assess whether the intervention effect significantly differed among the demographic subgroups. RESULTS:A total of 80 patients 21 to 87 years old were enrolled in the study from November 2015 to August 2016. Of the patients 53% were female and 49% were 65 years or younger. The incidence of those who considered the tablet to be the same or

Motivated by the need to predict how the Arctic atmosphere will change in a warming world, this article summarizes recent advances made by the research consortium NETCARE (Network on Climate and Aerosols: Addressing Key Uncertainties in Remote Canadian Environments) that contribute to our fundamental understanding of Arctic aerosol particles as they relate to climate forcing. The overall goal of NETCARE research has been to use an interdisciplinary approach encompassing extensive field observations and a range of chemical transport, earth system, and biogeochemical models. Several major findings and advances have emerged from NETCARE since its formation in 2013. (1) Unexpectedly high summertime dimethyl sulfide (DMS) levels were identified in ocean water (up to 75 nM) and the overlying atmosphere (up to 1 ppbv) in the Canadian Arctic Archipelago (CAA). Furthermore, melt ponds, which are widely prevalent, were identified as an important DMS source (with DMS concentrations of up to 6 nM and a potential contribution to atmospheric DMS of 20 % in the study area). (2) Evidence of widespread particle nucleation and growth in the marine boundary layer was found in the CAA in the summertime, with these events observed on 41 % of days in a 2016 cruise. As well, at Alert, Nunavut, particles that are newly formed and grown under conditions of minimal anthropogenic influence during the months of July and August are estimated to contribute 20 % to 80 % of the 30-50 nm particle number density. DMS-oxidation-driven nucleation is facilitated by the presence of atmospheric ammonia arising from seabird-colony emissions, and potentially also from coastal regions, tundra, and biomass burning. Via accumulation of secondary organic aerosol (SOA), a significant fraction of the new particles grow to sizes that are active in cloud droplet formation. Although the gaseous precursors to Arctic marine SOA remain poorly defined, the measured levels of common continental SOA precursors (isoprene

The Great Andromeda Galaxy (M31) is the nexus of the near-far galaxy evolution connection and a principal data point for near-field cosmology. Due to its proximity (780 kpc), M31 can be resolved into individual stars like the Milky Way (MW). Unlike the MW, we have the advantage of a global view of M31, enabling M31 to be observed with techniques that also apply to more distant galaxies. Moreover, recent evidence suggests that M31 may have survived a major merger within the last several Gyr, shaping the morphology of its stellar halo and triggering a starburst, while leaving the stellar disk largely intact. The MW and M31 thus provide complementary opportunities for in-depth studies of the disks, halos, and satellites of L* galaxies. Our understanding of the M31 system will be transformed in the 2020s if they include wide field facilities for both photometry (HST-like sensitivity and resolution) and spectroscopy (10-m class telescope, >1 sq. deg. field, highly multiplexed, R~ 3000 to 6000). We focus here on the power of these facilities to constrain the past, present, and future merger history of M31, via chemo-dynamical analyses and star formation histories of phase-mixed stars accreted at early times, as well as stars in surviving tidal debris features, M31's extended disk, and intact satellite galaxies that will eventually be tidally incorporated into the halo. This will yield an unprecedented view of the hierarchical formation of the M31 system and the subhalos that built it into the L* galaxy we observe today.

Nearly a century after the discovery that we live in an expanding Universe, and two decades after the discovery of accelerating cosmic expansion, there remains no direct detection of this acceleration via redshift drift - a change in the cosmological expansion velocity versus time. Because cosmological redshift drift directly determines the Hubble parameter H(z), it is arguably the cleanest possible measurement of the expansion history, and has the potential to constrain dark energy models (e.g. Kim et al. 2015). The challenge is that the signal is small - the best observational constraint presently has an uncertainty several orders of magnitude larger than the expected signal (Darling 2012). Nonetheless, direct detection of redshift drift is becoming feasible, with upcoming facilities such as the ESO-ELT and SKA projecting possible detection within two to three decades. This timescale is uncomfortably long given the potential of this cosmological test. With dedicated experiments it should be possible to rapidly accelerate progress and detect redshift drift with only a five-year observational baseline. Such a facility would also be ideal for precision radial velocity measurements of exoplanets, which could be obtained as a byproduct of the ongoing calibration measurements for the experiment.

We propose an experiment, the Cosmic Accelerometer, designed to yield velocity precision of $\leq 1$ cm/s with measurement stability over years to decades. The first-phase Cosmic Accelerometer, which is at the scale of the Astro2020 Small programs, will be ideal for precision radial velocity measurements of terrestrial exoplanets in the Habitable Zone of Sun-like stars. At the same time, this experiment will serve as the technical pathfinder and facility core for a second-phase larger facility at the Medium scale, which can provide a significant detection of cosmological redshift drift on a 6-year timescale. This larger facility will naturally provide further detection/study of Earth twin planet systems as part of its external calibration process. This experiment is fundamentally enabled by a novel low-cost telescope technology called PolyOculus, which harnesses recent advances in commercial off the shelf equipment (telescopes, CCD cameras, and control computers) combined with a novel optical architecture to produce telescope collecting areas equivalent to standard telescopes with large mirror diameters. Combining a PolyOculus array with an actively-stabilized high-precision radial velocity spectrograph provides a unique facility with novel calibration features to achieve the performance requirements for the Cosmic Accelerometer.

MegaMapper is a proposed ground-based experiment to measure Inflation parameters and Dark Energy from galaxy redshifts at 2

This dissertation offers a new narrative on the history of public debt in late Qing and Republican-era China (1850 – 1914), highlighting its links with late Qing and Republican political economy. A history of economic ideas and institutions, the dissertation draws from official and diplomatic communications, contemporary newspapers and journals, academic studies and private letters to explore the process of its embedment into Chinese fiscal system and its evolution in China as a set of discourses and practice, including its reception by officials, merchants and general public, and its adjustment to established discourses of political economy in late Qing and Republican China.Adopting an expansive conception of public debt to include related public credit mechanisms and discourses, the dissertation traces the impact of pre-1850 official debates on late 19th Century Chinese officials’ ambivalence towards modern public debt. It argues that a domestic intellectual and policy reorientation in favour of growth was needed and mostly achieved before Qing’s military defeat in 1895, paving the way for large-scale borrowing that in turn reconfigured state-society relations in late Qing. The dissertation also investigates how mid-Victorian liberal discourses on public debt were co-opted by Chinese reformists, which in their modified form of political and fiscal accountability, proved to be effective in dominating late Qing and Republican discourses on public debt.This dissertation is one of the first English-language studies discussing the evolution of economic ideas surrounding Chinese public debt. Recounting China’s historical experiences with public debt, and discourses on political economy that resulted from these experiences would promote a more layered understanding of public debt’s role for peripheral economies in the late 19th and 20th Century.

xThis dissertation examines the role of law in the formation of China’s earliest empires (221 BCE-220 CE). Using thousands of manuscripts written on bamboo and wood which have been excavated in China in the several decades, I argue that legal practice was central to the formation of imperial identity. Building on theoretical insights from the anthropology of paperwork, as well as from recent studies of manuscript culture, I argue that legal manuscripts can be read not only as representations or records of social conditions, but as material objects whose production and circulation itself constituted new forms of sociality. Eschewing a conventional law and society approach, my dissertation follows a diverse array of actors —women, servants, magistrates, foreigners and family members— as they use practices of writing and law to lodge claims of status, identity, kinship, and property. In linking newly excavated manuscripts with discussions of law and materiality, this dissertation aims to challenge multiple orthodoxies derived from notions of European legal and bureaucratic modernity. Accounts of early law have long cited certain types of legal text, such as penal statutes, as evidence for the idea that early law was informed by the rationality of state and directed at social control. By locating legal practice not in state sanction but in the circulation of legal manuscripts, I am able to reframe this persistent debate to take account both of newly discovered manuscripts and also to interpret receive sources in new ways. My dissertation thus complements and provides crucial context for revisionist trends in the historiography of imperial China that query the central presumption of despotism and legal orientalism. By linking law to material practices, I am further able to sidestep teleological narratives of rationalization and state control, and to provide a plausible explanation of why imperial legal culture could persist both beyond the geographic reach of the imperia

Midlife mortality has risen steadily in the U.S. since the 1990s for non-Hispanic whites without a bachelor’s degree, and since 2013 for Hispanics and African-Americans who lack a bachelor’s degree. These increases largely reflect increased mortality from alcohol poisoning, drug overdose and suicide. We investigate whether these “deaths of despair” trends have been mitigated by two key policies aimed at raising incomes for low wage workers: the minimum wage and the earned income tax credit (EITC). To do so, we leverage state variation in policies over time to estimate difference-in-differences models of drug overdose deaths and suicides, using data on cause-specific mortality rates from 1999-2015. Our causal models find no significant effects of the minimum wage and EITC on drug-related mortality. However, higher minimum wages and EITCs significantly reduce non-drug suicides. A 10 percent increase in the minimum wage reduces non-drug suicides among adults with high school or less by 3.6 percent; a 10 percent increase in the EITC reduces suicides among this group by 5.5 percent. Our estimated models do not find significant effects for a college-educated placebo sample. Event-study models confirm parallel pre-trends, further supporting the validity of our causal research design. Our estimates suggest that increasing both the minimum wage and the EITC by 10 percent would likely prevent a combined total of around 1230 suicides each year.

We measure the effects of six citywide minimum wages that ranged up to $13 in Chicago, the District of Columbia, Oakland, San Francisco, San Jose and Seattle, employing event study and synthetic control methods. Using aggregate data on average earnings and employment in the food services industry, we find significantly positive earnings increases and no significant employment losses. While such evidence suggests the policies raised the earnings of low-wage workers, as intended, a competing explanation is that the industry responds to wage increases by increasing their demand for more productive higher-wage workers, offsetting low-wage layoffs (i.e., labor-labor substitution). To tackle this key question, we present a theoretical framework that connects the responses estimated at the industry-level to the own- and cross-wage labor demand elasticities that summarize the total effect of the policies on workers. Using a calibration exercise, we find that the combination of average earnings gains and constant employment cannot be produced by labor-labor substitution unless there are also effects on hours. To test whether the minimum wage increases demand for higher-wage workers or reduces low-wage workers’ hours, we examine the effects of California’s recent state and local minimum wage policies on the food services industry. There we find no evidence of labor-labor substitution or hours responses. Thus, the most likely explanation for the responses we find in the cities is that the industry’s demand for low-wage workers is inelastic, and the policies raised their earnings.

A proposal to raise the federal minimum wage to $15 by 2024 would increase the relative minimum wage – the ratio to the national median wage– to about .68. In Alabama and Mississippi, our two lowest-wage states, the relative minimum wage would rise to .77 and .85, respectively. Yet research on state-level minimum wage policies does not extend beyond $10; the highest studied state-level relative minimum wage is .59. To close this gap we study minimum wage effects in counties and PUMAs where relative minimum wage ratios already reach as high as .82. Using ACS data since 2005 and 51 events, we sort counties and PUMAs according to their relative minimum wages and bites. We report average results for all the events in our sample, and separately for those with lower and higher impacts. We find positive wage effects but do not detect adverse effects on employment, weekly hours or annual weeks worked. We do not find negative employment effects among women, blacks and/or Hispanics. We do find substantial declines in household and child poverty.

How can librarians engage with the concept of collections in new ways? One answer to this question may be expanding the definition of collection management to include active creation and remixing of our collections. Taking on the role of data creator changes the narrative of what libraries do, enables librarians to model metadata creation standards and licensing best practices, and transforms existing analog collections into research-ready data collections. As a GIS and map librarian interested in these issues, I developed a project to scan physical maps from library collections and transform them into a GIS database covering 20th century Mongolia. The project resulted in a useful set of data for researchers, best practices that can be used in other similar projects, and an expanded concept of what it means to curate a geospatial collection.