19 results on '"magnusiomyces capitatus"'
Search Results
2. A case of Magnusiomyces capitatus isolated during monitoring in an antimicrobial diagnostic stewardship context.
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Foglia F, Greco G, Zannella C, Chianese A, Ambrosino A, Conzo A, Conzo G, De Filippis A, Finamore E, Docimo L, and Galdiero M
- Abstract
Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast in the Mediterranean region typically isolated from immunocompromised patients, usually affected by blood malignancies. We reported a rare case of M. capitatus infection, isolated from a drainage fluid in a patient affected by lung cancer recovered in the University Hospital of Campania "Luigi Vanvitelli", Naples, Italy. The isolate was identified by phenotypic methods, i.e., Gram and Lactophenol cotton blue (LCB) staining, and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis. We identified M. capitatus on the third day from Sabouraud Dextrose Agar supplemented with chloramphenicol and gentamicin. Antifungal susceptibility test revealed that 5-fluorocytosine was the most active drug against M. capitatus , followed by itraconazole and voriconazole, micafungin, amphotericin B and fluconazole, posaconazole, anidulafungin, and caspofungin. Our data showed the importance of an early cultural and fast microbiology diagnosis based on the characteristic morphologic features observed in Gram-stained smears of blood culture positive bottles, and the validation via MALDI-TOF MS. This dual approach has significant impact in the clinical management of infectious diseases and antibiotic stewardship, by integrating sample processing, fluid handling, and detection for rapid bacterial diagnosis., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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3. Saprochaete/Magnusiomyces: identification, virulence factors, and antifungal susceptibility of a challenging rare yeast.
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Kaşaltı B and Gülmez D
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- Yeasts, Candida, Esterases, Microbial Sensitivity Tests, Antifungal Agents pharmacology, Antifungal Agents therapeutic use, Virulence Factors genetics
- Abstract
Saprochaete/Magnusiomyces is among rare yeasts which might emerge as causes of breakthrough infections and nosocomial outbreaks. Identification to the species level might be a challenge in clinical laboratories. Data on virulence factors are scarce and antifungal susceptibility testing methodology is not definite. The aim of this study was to confirm species identification of clinical Saprochaete/Magnusiomyces isolates, find out their virulence factors, and obtain antifungal minimum inhibitory concentrations with two reference methods. Of the 57 isolates included, 54 were Saprochaete capitata and four were Saprochaete clavata as identified by ID32C, MALDI-TOF MS, and sequencing. When tested using phenotypic methods, all isolates were negative for coagulase, hemolysis, acid proteinase, and phospholipase, 56.1% were positive for esterase, and 19.3% had intermediate surface hydrophobicity. All isolates formed biofilms, with 40.4% of the isolates producing more biomass than biofilm-positive reference strain Candida albicans MYA-274. Antifungal susceptibility testing needed an adjusted spectrophotometric inoculum than recommended in reference methods for Candida/Cryptococcus. In conclusion, Saprochaete/Magnusiomyces species could be identified using methods available in the clinical laboratories. Despite the disadvantages of the phenotypic methods, esterase positivity was observed for the first time. A high biomass production was observed in biofilms. The need for standardization of antifungal susceptibility testing was brought to attention., (© 2024. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
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- 2024
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4. The first case of isolation of Magnusiomyces capitatus from the oral cavity of an addicted patient.
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Ghojoghi A, Khodavaisy S, Zarei Mahmoudabadi A, Hatami M, and Fatahinia M
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- Male, Humans, Adult, Nystatin, Mouth, Fluconazole, Microbial Sensitivity Tests, Antifungal Agents pharmacology, Antifungal Agents therapeutic use, Saccharomycetales genetics
- Abstract
Magnusiomyces capitatus (M. capitatus) is an emerging opportunistic yeast, rarely found as a causal agent of invasive fungal infection. In this study, we report a 31-year-old man infected with M. capitatus in the oral cavity, with a history of heroin and amphetamine abuse. M. capitatus was isolated through culture and microscopic analysis and identified by PCR amplification of the ITS DNA region. Based on the in vitro antifungal susceptibility test, the lowest MICs for M. capitatus were recorded for nystatin, itraconazole, and amphotericin, while higher MICs were observed for caspofungin and fluconazole. Treatment with nystatin successfully eliminated M. capitatus and relieved the clinical symptoms. This study presents the first case of M. capitatus in a patient with substance use disorder, manifesting as a plaque-like ulcer in the oral cavity., Competing Interests: No Conflict of Interest is declared, (Copyright (c) 2024 Aynaz Ghojoghi, Sadegh Khodavaisy, Ali Zarei Mahmoudabadi, Maryam Hatami, Mahnaz Fatahinia.)
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- 2024
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5. Fungemia Due to Saprochaete capitata in a Non-Neutropenic Critically Ill Patient.
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Mawad TN, Alfaifi RA, Almazyed OM, Alhumaidi RA, and Alsubaie AM
- Abstract
Saprochaete capitata is an uncommon yeast species; its impact on non-neutropenic patients appears to be on the rise. We describe a case of S. capitata fungemia in a critically ill end-stage kidney disease (ESKD) patient on peritoneal dialysis. The patient presented with mesenteric ischemia and underwent several laparotomies during hospitalization. His hospital stay was complicated as fungemia developed and spread to multiple sites, which resulted in severe complications and ultimately led to fatal outcomes. S. capitata 's diagnostic delay is a concern, but matrix-assisted laser desorption/Ionization time-of-flight (MALDI-TOF) mass spectrometry may help provide accurate identification. Our case highlights the need for prompt diagnosis and tailored antifungal therapy, especially when managing this challenging infection in immunocompromised patients., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Mawad et al.)
- Published
- 2023
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6. Magnusiomyces Capitatus Lung Nodule in a Patient with Nasopharyngeal and Hepatocellular Carcinoma.
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Lo SH, Wang HH, Chang YT, Lin CH, Lu PL, and Lin SY
- Abstract
Magnusiomyces capitatus is a dimorphic yeast commonly isolated from the environment and was uncommonly reported as a disease in Asia. It may cause invasive infection in patients with hematological malignancies, especially those with neutropenia, and resulting in high mortality. Herein, we reported a man with nasopharyngeal carcinoma and hepatocellular carcinoma suffered from intermittent fever after pulmonary nodules resection. The histopathology showed yeast-like fungal elements. For further identification, we extracted the tissue DNA from formalin-fixed paraffin-embedded tissue and M. capitatus was confirmed using polymerase chain reaction amplification and sequencing of the ITS region of ribosomal DNA. After a 4-week amphotericin B and flucytosine treatment, his condition recovered well and then was followed by a 3-month oral fluconazole treatment. There was no evidence of recurrence within one year. Our case highlights that nucleic acids obtained from formalin-fixed tissue could be a feasible identification method, especially in those whose culture results are unavailable., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)
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- 2023
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7. Saprochaete Capitata Peritonitis in a Non-neutropenic Patient Without Underlying Malignancies: A Case Report.
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Rahali FZ, Bounani F, Babokh F, and El Hakkouni A
- Abstract
Saprochaete capitata ( S. capitata ) is an opportunistic arthroconidial yeast-like fungus causing invasive infections in immunocompromised patients, mainly those with hematological malignancies and severe neutropenia. However, infections due to S. capitata are extremely rare in immunocompetent and non-neutropenic patients. Saprochaete spp. are microscopically characterized by arthroconidia with hyaline-septated hyphae. S. capitata is known to be intrinsically resistant to echinocandins and highly resistant to fluconazole. It is suggested to use amphotericin B or voriconazole (in monotherapy or in combination) as the gold standard treatment for S. capitata systemic infections. We report a rare case of S. capitata peritonitis with fatal outcome in a non-neutropenic patient without underlying malignancies. This case report highlights the value of direct microscopic examination and stained smears in a prompt preliminary diagnosis of S. capitata invasive fungal infections. We also aim to emphasize the importance of early initiation of appropriate antifungal treatment in patients with S. capitata systemic infections, thus improving their therapeutic outcome., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Rahali et al.)
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- 2023
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8. Invasive Fungal Infection Caused by Magnusiomyces capitatus in an Immunocompromised Pediatric Patient with Acute Lymphoblastic Leukemia in Mexico City: A Case Report.
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Ortiz-Álvarez J, Reséndiz-Sánchez J, Juárez-Montiel M, Hernández-García JA, Vázquez-Guerrero E, Hernández-Rodríguez C, and Villa-Tanaca L
- Abstract
Magnusiomyces capitatus (also denominated “Geotrichum capitatum” and “the teleomorph stage of Saprochaete capitata”) mainly affects immunocompromised patients with hematological malignancies in rare cases of invasive fungal infections (IFIs). Few cases have been reported for pediatric patients with acute lymphoblastic leukemia (ALL), in part because conventional diagnostic methods do not consistently detect M. capitatus in infections. The current contribution describes a systemic infection in a 15-year-old female diagnosed with ALL. She arrived at the Children’s Hospital of Mexico City with a fever and neutropenia and developed symptoms of septic shock 4 days later. M. capitatus ENCB-HI-834, the causal agent, was isolated from the patient’s blood, urine, bile, and peritoneal fluid samples. It was identified with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and a phylogenetic reconstruction using internal transcribed spacer (ITS) and 28S ribosomal sequences. The phylogenetic sequence of M. capitatus ENCB-HI-834 clustered with other M. capitatus-type strains with a 100% identity. In vitro antifungal testing, conducted with the Sensititre YeastOne susceptibility system, found the following minimum inhibitory concentration (MIC) values (μg/mL): posaconazole 0.25, amphotericin B 1.0, fluconazole > 8.0, itraconazole 0.25, ketoconazole 0.5, 5-flucytosine ≤ 0.06, voriconazole 0.25, and caspofungin > 16.0. No clinical breakpoints have been defined for M. capitatus. This is the first clinical case reported in Mexico of an IFI caused by M. capitatus in a pediatric patient with ALL. It emphasizes the importance of close monitoring for a timely and accurate diagnosis of neutropenia-related IFIs to determine the proper treatment with antibiotics, antifungals, and chemotherapy for instance including children with ALL.
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- 2022
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9. Factors Associated with Breakthrough Fungemia Caused by Candida , Trichosporon , or Fusarium Species in Patients with Hematological Disorders.
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Kimura M, Asano-Mori Y, Sakoh T, Abe M, Ueno K, Hoshino Y, Nakamura S, Umeyama T, Yamagoe S, Miyazaki Y, Baba M, Okada C, Ogura S, Mitsuki T, Yamaguchi K, Yuasa M, Kaji D, Kageyama K, Nishida A, Taya Y, Ishiwata K, Takagi S, Yamamoto H, Yamamoto G, Uchida N, Wake A, Taniguchi S, and Araoka H
- Subjects
- Adult, Antifungal Agents therapeutic use, Candida, Humans, Middle Aged, Candidemia drug therapy, Cryptococcus neoformans, Fungemia drug therapy, Fungemia microbiology, Fusarium, Hematologic Diseases complications, Hematologic Diseases drug therapy, Trichosporon
- Abstract
Limited data are available on breakthrough fungemia, defined as fungemia that develops on administration of antifungal agents, in patients with hematological disorders. We reviewed the medical and microbiological records of adult patients with hematological diseases who had breakthrough fungemia between January 2008 and July 2019 at Toranomon Hospital and Toranomon Hospital Kajigaya in Japan. A total of 121 cases of breakthrough fungemia were identified. Of the 121 involved patients, 83, 11, 5, and 22 were receiving micafungin, voriconazole, itraconazole, and liposomal amphotericin B, respectively, when the breakthrough occurred. Of the 121 causative breakthrough fungal strains, 96 were Candida species, and the rest were 13 cases of Trichosporon species, 7 of Fusarium species, 2 of Rhodotorula mucilaginosa, and 1 each of Cryptococcus neoformans, Exophiala dermatitidis, and Magnusiomyces capitatus. The crude 14-day mortality rate of breakthrough fungemia was 36%. Significant independent factors associated with the crude 14-day mortality rate were age of ≥60 years ( P = 0.011), chronic renal failure ( P = 0.0087), septic shock ( P < 0.0001), steroid administration ( P = 0.0085), and liposomal amphotericin B breakthrough fungemia ( P = 0.0011). An absolute neutrophil count of >500/μL was significantly more common in candidemia in the multivariate analysis ( P = 0.0065), neutropenia and nonallogeneic hematopoietic stem cell transplants were significantly more common in Trichosporon fungemia ( P = 0.036 and P = 0.033, respectively), and voriconazole breakthrough fungemia and neutropenia were significantly more common in Fusarium fungemia ( P = 0.016 and P = 0.016, respectively). The epidemiological and clinical characteristics of breakthrough fungemia of patients with hematological disorders were demonstrated. Some useful factors to predict candidemia, Trichosporon fungemia, and Fusarium fungemia were identified.
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- 2022
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10. Bloodstream Infections Caused by Magnusiomyces capitatus and Magnusiomyces clavatus : Epidemiological, Clinical, and Microbiological Features of Two Emerging Yeast Species.
- Author
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Noster J, Koeppel MB, Desnos-Olivier M, Aigner M, Bader O, Dichtl K, Göttig S, Haas A, Kurzai O, Pranada AB, Stelzer Y, Walther G, and Hamprecht A
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- Antifungal Agents pharmacology, Antifungal Agents therapeutic use, Humans, Male, Microbial Sensitivity Tests, Phylogeny, Saccharomycetales genetics, Sepsis drug therapy
- Abstract
Magnusiomyces clavatus and Magnusiomyces capitatus are emerging yeasts with intrinsic resistance to many commonly used antifungal agents. Identification is difficult, and determination of susceptibility patterns with commercial and reference methods is equally challenging. For this reason, few data on invasive infections by Magnusiomyces spp. are available. Our objectives were to determine the epidemiology and susceptibility of Magnusiomyces isolates from bloodstream infections (BSI) isolated in Germany and Austria from 2001 to 2020. In seven institutions, a total of 34 Magnusiomyces BSI were identified. Identification was done by internal transcribed spacer (ITS) sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Antifungal susceptibility was determined by EUCAST broth microdilution and gradient tests. Of the 34 isolates, M. clavatus was more common ( n = 24) than M. capitatus ( n = 10). BSI by Magnusiomyces spp. were more common in men (62%) and mostly occurred in patients with hemato-oncological malignancies (79%). The highest in vitro antifungal activity against M. clavatus / M. capitatus was observed for voriconazole (MIC
50 , 0.03/0.125 mg/L), followed by posaconazole (MIC50 , 0.125/0.25 mg/L). M. clavatus isolates showed overall lower MICs than M. capitatus . With the exception of amphotericin B, low essential agreement between gradient test and microdilution was recorded for all antifungals (0 to 70%). Both species showed distinct morphologic traits on ChromAgar Orientation medium and Columbia blood agar, which can be used for differentiation if no MALDI-TOF MS or molecular identification is available. In conclusion, most BSI were caused by M. clavatus. The lowest MICs were recorded for voriconazole. Gradient tests demonstrated unacceptably low agreement and should preferably not be used for susceptibility testing of Magnusiomyces spp.- Published
- 2022
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11. Invasive infections due to Magnusiomyces capitatus : case report and review of its prevalence in China.
- Author
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Zhu M, Yan L, de Hoog S, Liao W, Zhang H, Zhao R, and Deng S
- Abstract
Magnusiomyces capitatus is an emerging opportunistic yeast, thus far mainly reported from the Western world where fungemia is the most frequent presentation in immunocompromised patients with high mortality. We described a rare case of Magnusiomyces capitatus infection from our hospital in China and reviewed six further cases published to date in Chinese literature. It is noted that half more of the cases (4/7) presented with fungemia in younger, immunosuppressed patients, whereas the remaining cases were with pneumonia in elderly, immunocompetent patients. All seven Chinese cases had favourable outcome with antifungal therapy. Based on the limited in vitro and clinical data, a combination of amphotericin B either with 5-fluorocytosine or voriconazole for fungemia in immunocompromised patients, and although fluconazole is not recommended as first-line therapy in the guideline, in our study, fluconazole alone or with 5-fluorocytosine for local pulmonary infection in immunocompetent patients is effective with good outcome., Competing Interests: All authors do not have any conflicts of interest to disclose., (© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.)
- Published
- 2021
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12. Invasive Saprochaete Infections: An Emerging Threat to Immunocompromised Patients.
- Author
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El Zein S, Hindy JR, and Kanj SS
- Abstract
Saprochaete clavata and Saprochaete capitata are emerging fungal pathogens that are responsible for life threatening infections in immunocompromised patients, particularly in the setting of profound neutropenia. They have been associated with multiple hospital outbreaks mainly in Europe. In this article, we present a comprehensive review of the epidemiology, clinical presentation, diagnosis, antifungal susceptibility and treatment of these organisms. The diagnosis of invasive Saprochaete disease is challenging and relies primarily on the isolation of the fungi from blood or tissue samples. Both species are frequently misidentified as they are identical macroscopically and microscopically. Internal transcribed spacer sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry are useful tools for the differentiation of these fungi to a species level. Saprochaete spp. are intrinsically resistant to echinocandins and highly resistant to fluconazole. Current literature suggests the use of an amphotericin B formulation with or without flucytosine for the initial treatment of these infections. Treatment with extended spectrum azoles might be promising based on in vitro minimum inhibitory concentration values and results from case reports and case series. Source control and recovery of the immune system are crucial for successful therapy.
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- 2020
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13. Fungal Endogenous Endophthalmitis Secondary to Magnusiomyces capitatus .
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Rota N, Danese C, Menchini F, Pignatto S, Peghin M, Bassetti M, and Lanzetta P
- Abstract
We report the case of a 68-year-old immunocompetent patient with a dilatation of the ascending aorta, intraluminal vegetations, and pseudoaneurysmatic bulging who presented with unilateral fungal endogenous endophthalmitis 8 days after coronary angiogram. The isolated pathogen resulted to be Magnusiomyces capitatus , a filamentous, yeast-like fungus that can be commonly found in normal human microflora, with an immunosuppression-related pathogenicity. A literature research revealed a single case of ophthalmic infection - a keratitis - caused by this pathogen. Furthermore, we add a review of mycotic endophthalmitis related to aortic infection., Competing Interests: Nestore Rota: none; Carla Danese: none; Francesca Menchini: Novartis Pharma AG, consultant; Maddalena Peghin: Pfizer, financial support; MSD, financial support; Dia Sorin, financial support; Matteo Bassetti: Angelini, financial support, recipient; AstraZeneca, financial support, recipient; Bayer, financial support, recipient; Cidara, financial support, recipient; Cubist, financial support, recipient; Pfizer, financial support, recipient; Menarini, financial support, recipient; MSD, financial support, recipient; Nabriva, financial support, recipient; Paratek, financial support, recipient; Roche, financial support, recipient; Shionogi, financial support, recipient; Tetraphase, financial support, recipient; The Medicine Company financial support, recipient; Astellas Pharma Inc., financial support, recipient; Paolo Lanzetta: Bayer, consultant; Centervue, consultant; Novartis Pharma AG, consultant., (Copyright © 2019 by S. Karger AG, Basel.)
- Published
- 2019
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14. Magnusiomyces capitatus fungemia: The value of direct microscopy in early diagnosis.
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Alobaid K, Abdullah AA, Ahmad S, Joseph L, and Khan Z
- Abstract
Two cases of fungemia caused by Magnusiomyces capitatus, an arthroconidial yeast-like fungus, in non-hematologic immunocompromised patients are described. Both patients died before definite diagnosis of M. capitatus was made. The report highlights that pending confirmation of the isolate by phenotypic and/or molecular methods, the characteristic morphologic features observed in Gram-stained smears of blood culture positive bottles can lead to early preliminary diagnosis, thus significantly reducing time required for initiating appropriate antifungal therapy.
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- 2019
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15. A Case of Magnusiomyces capitatus Peritonitis Without Underlying Malignancies.
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D'Assumpcao C, Lee B, and Heidari A
- Abstract
Magnusiomyces capitatus is a rare cause of fungal infection in immunocompromised patients, mainly seen in hematological malignancies. M capitatus infections are extremely rare in immunocompetent patients, as it is part of normal human microbial flora. We are presenting an extremely rare case of M capitatus peritonitis in an otherwise immunocompetent patient who suffered from gastrointestinal leakage due to pancreatitis. Fungal identification was performed at reference laboratory by phenotypic characteristics and DNA sequencing of target internal transcribed spacer region of the rRNA gene and the D1-D2 domain of the large-subunit rRNA gene and susceptibility testing by Clinical and Laboratory Standards Institute guidelines (document M27-S4) broth dilution method. He was successfully treated with a combination of surgical repair and voriconazole single therapy., Competing Interests: Declaration of Conflicting Interests: The authors(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2018
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16. Management and treatment of Magnusiomyces capitatus (Geotrichum capitatum) pleural infection in a non-neutropenic patient with posaconazole. A new therapeutic opportunity?
- Author
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Brunetti G, Visconti V, Ghezzi MC, Mantovani S, Ferretti G, and Raponi G
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- Aged, Female, Humans, Antifungal Agents therapeutic use, Geotrichosis drug therapy, Geotrichosis microbiology, Geotrichum, Triazoles therapeutic use
- Abstract
Magnusiomyces capitatus may cause uncommon yet severe infections, especially in patients with haematologic disorders. Diagnosis may be difficult and time-consuming and newer approaches are required including the MALDI-TOF technique implemented with the detection of fungal antigens in the body fluids. The recommended treatment includes amphotericin B alone or in combination with flucytosine. We describe a case of a non-neutropenic patient with M. capitatus pleural infection, as identified by MALDI-TOF, positivity for galactomannan antigen in the BAL fluid, and successfully treated with oral posaconazole in single therapy.
- Published
- 2016
17. Isolation of KPC 3-producing Enterobacter aerogenes in a patient colonized by MDR Klebsiella pneumoniae.
- Author
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Venditti C, Villa L, Capone A, Fortini D, D'Arezzo S, Nisii C, Bordi E, Puro V, Antonini M, Carattoli A, Cataldo MA, Petrosillo N, and Di Caro A
- Subjects
- Gene Transfer, Horizontal, Humans, Male, Plasmids, Bacterial Proteins genetics, Enterobacter aerogenes genetics, Klebsiella pneumoniae genetics, beta-Lactamases genetics
- Abstract
We describe the interspecies transmission of the plasmid-mediated blaKPC-3 gene, which confers carbapenem resistance, between clinically relevant gram-negative bacteria in a single patient. A KPC-3 producing Enterobacter aerogenes was isolated from a hospitalized patient previously colonized and then infected by a Klebsiella pneumoniae ST101 carrying the blaKPC-3 gene. The strains showed identical plasmids. Since intense horizontal exchanges among bacteria can occur in the gut, clinicians should be aware that patients colonized by carbapenem-resistant K. pneumoniae could become carriers of other carbapenem-resistant Enterobacteriaceae.
- Published
- 2016
18. [Disseminated fungal infection due to Magnusiomyces capitatus in a liver graft patient].
- Author
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Yapo-Kouadio CG, Hasseine L, Goubaux B, and Gari-Toussaint M
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- Fatal Outcome, Fungemia complications, Graft Rejection microbiology, Humans, Immunocompromised Host, Male, Middle Aged, Sepsis complications, Sepsis microbiology, Fungemia diagnosis, Fungemia microbiology, Liver Transplantation adverse effects, Saccharomycetales isolation & purification
- Abstract
Disseminated fungal infections due to Magnusiomyces capitatus are rare, occurring exclusively in immunocompromised patients. We report the first case in a liver transplant patient with chronic rejection and portal thrombosis who had a M. capitatus fungemia with a refractory septic shock. Despite an antibacterial and antifungal treatment with caspofungin empirical treatment, the patient died from multiple organ failure. Subsequently, mycological examinations of blood cultures, bronchoalveolar lavage fluid and urine were positive to M. capitatus identified by mass spectrometry and confirmed by sequencing respectively. The stain was resistant to caspofungin and fluconazole. The best treatment appears to be the combination of amphotericin B and voriconazole or amphotericin B and 5 fluorocytosine., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)
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- 2016
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19. Emergence of Magnusiomyces capitatus infections in Western Nepal.
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Subramanya Supram H, Gokhale S, Chakrabarti A, Rudramurthy SM, Gupta S, and Honnavar P
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- Adolescent, Aged, Aged, 80 and over, Amplified Fragment Length Polymorphism Analysis, Antifungal Agents pharmacology, Cluster Analysis, DNA, Fungal chemistry, DNA, Fungal genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, DNA, Ribosomal Spacer chemistry, DNA, Ribosomal Spacer genetics, Female, Humans, Immunocompromised Host, Male, Microbial Sensitivity Tests, Middle Aged, Molecular Sequence Data, Molecular Typing, Mycological Typing Techniques, Nepal epidemiology, Phylogeny, RNA, Ribosomal genetics, Saccharomycetales genetics, Saccharomycetales physiology, Sequence Analysis, DNA, Tertiary Care Centers, Mycoses epidemiology, Mycoses microbiology, Saccharomycetales classification, Saccharomycetales isolation & purification
- Abstract
Magnusiomyces capitatus is an emerging opportunistic yeast in the Mediterranean region. We report from Nepal one case of M. capitatus infection and six other cases of colonization/probable infection due to M. capitatus at a tertiary care center. Majority of the patients were immunocompromised, at extreme age, associated with comorbidities, and had history of close contact with livestock and poultry. The isolates were identified by phenotypic and genotypic (ITS and D1/D2 region of 26S rDNA sequence) methods. Molecular typing of the isolates was carried out by amplified fragment length polymorphism. Minimum inhibitory concentration (MIC) of the isolates for amphotericin B, caspofungin, fluconazole, itraconazole, voriconazole, posaconazole, anidulafungin, and micafungin were 2, 0.1-4, 2, 0.12-0.5, 0.12-0.5, 0.25, 1-4, and 1-4 μg/ml, respectively. Presence of M. capitatus infection was not known in Nepal, and the study should alert the clinicians and infectious disease specialists., (© The Author 2015. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2016
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