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Background: The concept of digital twins, widely adopted in industry, is entering health care. However, there is a lack of consensus on what constitutes the digital twin of a patient., Objective: The objective of this scoping review was to analyze definitions and characteristics of patient digital twins being developed for clinical use, as reported in the scientific literature., Methods: We searched PubMed, Scopus, Embase, IEEE, and Google Scholar for studies claiming digital twin development or evaluation until August 2023. Data on definitions, characteristics, and development phase were extracted. Unsupervised classification of claimed digital twins was performed., Results: We identified 86 papers representing 80 unique claimed digital twins, with 98% (78/80) in preclinical phases. Among the 55 papers defining "digital twin," 76% (42/55) described a digital replica, 42% (23/55) mentioned real-time updates, 24% (13/55) emphasized patient specificity, and 15% (8/55) included 2-way communication. Among claimed digital twins, 60% (48/80) represented specific organs (primarily heart: 15/48, 31%; bones or joints: 10/48, 21%; lung: 6/48, 12%; and arteries: 5/48, 10%); 14% (11/80) embodied biological systems such as the immune system; and 26% (21/80) corresponded to other products (prediction models, etc). The patient data used to develop and run the claimed digital twins encompassed medical imaging examinations (35/80, 44% of publications), clinical notes (15/80, 19% of publications), laboratory test results (13/80, 16% of publications), wearable device data (12/80, 15% of publications), and other modalities (32/80, 40% of publications). Regarding data flow between patients and their virtual counterparts, 16% (13/80) claimed that digital twins involved no flow from patient to digital twin, 73% (58/80) used 1-way flow from patient to digital twin, and 11% (9/80) enabled 2-way data flow between patient and digital twin. Based on these characteristics, unsupervised classification revealed 3 clusters: simulation patient digital twins in 54% (43/80) of publications, monitoring patient digital twins in 28% (22/80) of publications, and research-oriented models unlinked to specific patients in 19% (15/80) of publications. Simulation patient digital twins used computational modeling for personalized predictions and therapy evaluations, mostly for one-time assessments, and monitoring digital twins harnessed aggregated patient data for continuous risk or outcome forecasting and care optimization., Conclusions: We propose defining a patient digital twin as "a viewable digital replica of a patient, organ, or biological system that contains multidimensional, patient-specific information and informs decisions" and to distinguish simulation and monitoring digital twins. These proposed definitions and subtypes offer a framework to guide research into realizing the potential of these personalized, integrative technologies to advance clinical care., (©David Drummond, Apolline Gonsard. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 13.11.2024.)

Cyber-physical systems (CPSs) are evolving from individual systems to collectives of systems that collaborate to achieve highly complex goals, realizing a cyber-physical system of systems (CPSoSs) approach. They are heterogeneous systems comprising various autonomous CPSs, each with unique performance capabilities, priorities, and pursued goals. In practice, there are significant challenges in the applicability and usability of CPSoSs that need to be addressed. The decentralization of CPSoSs assigns tasks to individual CPSs within the system of systems. All CPSs should harmonically pursue system-based achievements and collaborate to make system-of-system-based decisions and implement the CPSoS functionality. The automotive domain is transitioning to the system of systems approach, aiming to provide a series of emergent functionalities like traffic management, collaborative car fleet management, or large-scale automotive adaptation to the physical environment, thus providing significant environmental benefits and achieving significant societal impact. Similarly, large infrastructure domains are evolving into global, highly integrated cyber-physical systems of systems, covering all parts of the value chain. This survey provides a comprehensive review of current best practices in connected cyber-physical systems and investigates a dual-layer architecture entailing perception and behavioral components. The presented perception layer entails object detection, cooperative scene analysis, cooperative localization and path planning, and human-centric perception. The behavioral layer focuses on human-in-the-loop (HITL)-centric decision making and control, where the output of the perception layer assists the human operator in making decisions while monitoring the operator's state. Finally, an extended overview of digital twin (DT) paradigms is provided so as to simulate, realize, and optimize large-scale CPSoS ecosystems., Competing Interests: Author PR-G was employed by K3Y Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Piperigkos, Gkillas, Arvanitis, Nousias, Lalos, Fournaris, Radoglou-Grammatikis, Sarigiannidis and Moustakas.)

A mini-review of the literature, supporting the view on the psychophysical origins of some user acceptance effects of cyber-physical systems (CPSs), is presented and discussed in this paper. Psychophysics implies the existence of a lawful functional dependence between some aspect/dimension of the stimulation from the environment, entering the senses of the human, and the psychological effect that is being produced by this stimulation, as reflected in the subjective responses. Several psychophysical models are discussed in this mini-review, aiming to support the view that the observed effects of reactance to a robot or the uncanny valley phenomenon are essentially the same subjective effects of different intensity. Justification is provided that human responses to technologically and socially ambiguous stimuli obey some regularity, which can be considered a lawful dependence in a psychophysical sense. The main conclusion is based on the evidence that psychophysics can provide useful and helpful, as well as parsimonious, design recommendations for scenarios with CPSs for social applications., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Dimitrova, Chehlarova, Madzharov, Krastev and Chavdarov.)

Smart grids arose as the largest cyber-physical systems with the integration of sophisticated control, computing, and state-of-the-art communications. Like all cyber-physical systems, the smart grids are vulnerable to malicious cyber assaults due to their enormous dependency on communication networks. Various machine learning-based schemes are being investigated in the industry and academia to develop robust defense mechanisms to counter cyber assaults. However, the curse of high dimensionality, which increases with the escalating evolution of an electric power system, infringes upon the efficiency of machine learning models employed to detect such assaults. To this end, this paper proposes a deep denoising autoencoder (DAE)-based framework for dimensionality reduction that learns salient feature representation for high-dimensional, multi-variant smart grid measurement data collected from the smart grids. The latent space apprehended by DAE is then fed to binary support vector machine (SVM) to determine the assaulted data. Various standard IEEE test cases are employed in simulations. The results show that the proposed scheme learns more robust features that reveal the nonlinear properties exhibited in the smart grid measurements, further leading to improved detection accuracy of the classifier as compared to existing approaches., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Power electronic converters are widely implemented in many types of power applications such as microgrids. Power converters can make a physical connection between the power resources and the power application. To control a power converter, required data such as the voltage and the current of that should be measured to be used in a control application. Therefore, a communication-based structure including sensors and communication links can be used to measure the desired data and transmit that to the controllers. So, a power converter-based system can be considered as a type of cyber-physical system, and it can be vulnerable to cyber-attacks. Then, it can strongly be recommended to use a strategy for a power converter-based system to monitor the system and identify the existence of cyber-attack in the system. In this study, artificial intelligence (AI) is deployed to calculate the value of the false data (i.e., constant false data, and time-varying false data) and detect false data injection cyber-attacks on power converters. Besides, to have a precise technical evaluation of the proposed methodology, that is evaluated under other issues, i.e., noise, and communication link delay. In the case of noise, the proposed strategy is examined under noises with different signal-to-noise ratios . Further, for the case of the communication delay, the system is examined under both symmetrical (i.e., same communication delay on all inputs) and unsymmetrical communication delays (i.e., different communication delay/delays on the inputs). In this work, artificial neural networks are implemented as the AI-based application, and two types of the networks, i.e., feedforward (as a basic type) and long short-term memory (LSTM)-based network as a more complex network are tested. Finally, three important AI-based techniques (regression, classification, and clustering) are examined. Based on the obtained results, this work can properly identify and calculate the false data in the system., (© 2024. The Author(s).)

Today, Smart Assistants (SAs) are supported by significantly improved Natural Language Processing (NLP) and Natural Language Understanding (NLU) engines as well as AI-enabled decision support, enabling efficient information communication, easy appliance/device control, and seamless access to entertainment services, among others. In fact, an increasing number of modern households are being equipped with SAs, which promise to enhance user experience in the context of smart environments through verbal interaction. Currently, the market in SAs is dominated by products manufactured by technology giants that provide well designed off-the-shelf solutions. However, their simple setup and ease of use come with trade-offs, as these SAs abide by proprietary and/or closed-source architectures and offer limited functionality. Their enforced vendor lock-in does not provide (power) users with the ability to build custom conversational applications through their SAs. On the other hand, employing an open-source approach for building and deploying an SA (which comes with a significant overhead) necessitates expertise in multiple domains and fluency in the multimodal technologies used to build the envisioned applications. In this context, this paper proposes a methodology for developing and deploying conversational applications on the edge on top of an open-source software and hardware infrastructure via a multilayer architecture that simplifies low-level complexity and reduces learning overhead. The proposed approach facilitates the rapid development of applications by third-party developers, thereby enabling the establishment of a marketplace of customized applications aimed at the smart assisted living domain, among others. The supporting framework supports application developers, device owners, and ecosystem administrators in building, testing, uploading, and deploying applications, remotely controlling devices, and monitoring device performance. A demonstration of this methodology is presented and discussed focusing on health and assisted living applications for the elderly.

Recently, research has been conducted on mixed reality (MR), which provides immersive visualization and interaction experiences, and on mapping human motions directly onto a robot in a mixed reality (MR) space to achieve a high level of immersion. However, even though the robot is mapped onto the MR space, their surrounding environment is often not mapped sufficiently; this makes it difficult to comfortably perform tasks that require precise manipulation of the objects that are difficult to see from the human perspective. Therefore, we propose a system that allows users to operate a robot in real space by mapping the task environment around the robot on the MR space and performing operations within the MR space.

Cyber-physical systems (CPS) are vital in automating complex tasks across various sectors, yet they face significant vulnerabilities due to the rising threats of cybersecurity attacks. The recent surge in cyber-attacks on critical infrastructure (CI) and industrial control systems (ICSs), with a 150% increase in 2022 affecting over 150 industrial operations, underscores the urgent need for advanced cybersecurity strategies and education. To meet this requirement, we develop a specialised cyber-physical testbed (CPT) tailored for transportation CI, featuring a simplified yet effective automated level-crossing system. This hybrid CPT serves as a cost-effective, high-fidelity, and safe platform to facilitate cybersecurity education and research. High-fidelity networking and low-cost development are achieved by emulating the essential ICS components using single-board computers (SBC) and open-source solutions. The physical implementation of an automated level-crossing visualised the tangible consequences on real-world systems while emphasising their potential impact. The meticulous selection of sensors enhances the CPT, allowing for the demonstration of analogue transduction attacks on this physical implementation. Incorporating wireless access points into the CPT facilitates multi-user engagement and an infrared remote control streamlines the reinitialization effort and time after an attack. The SBCs overwhelm as traffic surges to 12 Mbps, demonstrating the consequences of denial-of-service attacks. Overall, the design offers a cost-effective, open-source, and modular solution that is simple to maintain, provides ample challenges for users, and supports future expansion.

The finite-horizon optimal secure tracking control (FHOSTC) problem for cyber-physical systems under actuator denial-of-service (DoS) attacks is addressed in this paper. A model-free method based on the Q-function is designed to achieve FHOSTC without the system model information. First, an augmented time-varying Riccati equation (TVRE) is derived by integrating the system with the reference system into a unified augmented system. Then, a lower bound on malicious DoS attacks probability that guarantees the solutions of the TVRE is provided. Third, a Q-function that changes over time (time-varying Q-function, TVQF) is devised. A TVQF-based method is then proposed to solve the TVRE without the need for the knowledge of the augmented system dynamics. The developed method works backward-in-time and uses the least-squares method. To validate the performance and features of the developed method, simulation studies are conducted in the end., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 ISA. Published by Elsevier Ltd. All rights reserved.)

The evolution of engineering applications is highly relevant in the context of protecting industrial systems. As industries are increasingly interconnected, the need for robust cybersecurity measures becomes paramount. Engineering informatics not only provides tools for knowledge representation and extraction but also affords a comprehensive spectrum of developing sophisticated cybersecurity solutions. However, safeguarding industrial systems poses a unique challenge due to the inherent heterogeneity of data within these environments. Together with this problem, it's crucial to acknowledge that datasets that simulate real cyberattacks within these diverse environments exhibit a high imbalance, often skewed towards certain types of traffics. This study proposes a system for addressing class imbalance in cybersecurity. To do this, three oversampling (SMOTE, Borderline1-SMOTE, and ADASYN) and five undersampling (random undersampling, cluster centroids, NearMiss, repeated edited nearest neighbor, and Tomek Links) methods are tested. Particularly, these balancing algorithms are used to generate one- vs -rest binary models and to develop a two-stage classification system. By doing so, this study aims to enhance the efficacy of cybersecurity measures ensuring a more comprehensive understanding and defense against the diverse range of threats encountered in industrial environments. Experimental results demonstrates the effectiveness of proposed system for cyberattack detection and classification among nine widely known cyberattacks., Competing Interests: The authors declare that they have no competing interests., (© 2024 Mogollón Gutiérrez et al.)

The fifth Industrial revolution (I5.0) prioritizes resilience and sustainability, integrating cognitive cyber-physical systems and advanced technologies to enhance machining processes. Numerous research studies have been conducted to optimize machining operations by identifying and reducing sources of uncertainty and estimating the optimal cutting parameters. Virtual modeling and Tool Condition Monitoring (TCM) methodologies have been developed to assess the cutting states during machining processes. With a precise estimation of cutting states, the safety margin necessary to deal with uncertainties can be reduced, resulting in improved process productivity. This paper reviews the recent advances in high-performance machining systems, with a focus on cyber-physical models developed for the cutting operation of difficult-to-cut materials using cemented carbide tools. An overview of the literature and background on the advances in offline and online process optimization approaches are presented. Process optimization objectives such as tool life utilization, dynamic stability, enhanced productivity, improved machined part quality, reduced energy consumption, and carbon emissions are independently investigated for these offline and online optimization methods. Addressing the critical objectives and constraints prevalent in industrial applications, this paper explores the challenges and opportunities inherent to developing a robust cyber-physical optimization system.

Describing the properties of complex systems that evolve over time is a crucial requirement for monitoring and understanding them. Signal Temporal Logic (STL) is a framework that proved to be effective for this aim because it is expressive and allows state properties as human-readable formulae. Crafting STL formulae that fit a particular system is, however, a difficult task. For this reason, a few approaches have been proposed recently for the automatic learning of STL formulae starting from observations of the system. In this paper, we propose BUSTLE (Bi-level Universal STL Evolver), an approach based on evolutionary computation for learning STL formulae from data. BUSTLE advances the state-of-the-art because it (i) applies to a broader class of problems, in terms of what is known about the state of the system during its observation, and (ii) generates both the structure and the values of the parameters of the formulae employing a bi-level search mechanism (global for the structure, local for the parameters). We consider two cases where (a) observations of the system in both anomalous and regular state are available, or (b) only observations of regular state are available. We experimentally evaluate BUSTLE on problem instances corresponding to the two cases and compare it against previous approaches. We show that the evolved STL formulae are effective and human-readable: the versatility of BUSTLE does not come at the cost of lower effectiveness., (© 2024 Massachusetts Institute of Technology.)

Recently, the European Commission announced Industry 5.0 as a strategic initiative toward a value-driven industrial transformation. This new paradigm coexists with previous Industry 4.0 revolution that has guided the efforts towards technology driven industrial digitalisation in the past ten years. As part of this Industry 4.0 strategies, numerous KPI-driven evaluation methods were proposed to cover the multiple pillars of smart industry assessment. However, they do not incorporate human workers and actors in a systematic way as drivers for digitalisation processes, as the new Industry 5.0 paradigm argues. This paper addresses this gap by proposing an evaluation methodology that incorporates multiple human actors in the digitalisation process. The final objective of this methodology is to evaluate the direct and indirect benefits of the technology-driven transformation process to achieve the goals of human workers and other human stakeholders. To this end, our methodology provides the basis for proposing assessment tools and instruments for technological and infrastructure integration, process optimisation, new functionalities and human factors benefits, and four core indicators that have been applied to a real case comparing the digitalisation processes of three different companies., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Background: Sports have been a fundamental component of any culture and legacy for centuries. Athletes are widely regarded as a source of national pride, and their physical well-being is deemed to be of paramount significance. The attainment of optimal performance and injury prevention in athletes is contingent upon physical fitness. Technology integration has implemented Cyber-Physical Systems (CPS) to augment the athletic training milieu., Objective: The present study introduces an approach for assessing athlete physical fitness in training environments: the Internet of Things (IoT) and CPS-based Physical Fitness Evaluation Method (IoT-CPS-PFEM)., Methods: The IoT-CPS-PFEM employs a range of IoT-connected sensors and devices to observe and assess the physical fitness of athletes. The proposed methodology gathers information on diverse fitness parameters, including heart rate, body temperature, and oxygen saturation. It employs machine learning algorithms to scrutinize and furnish feedback on the athlete's physical fitness status., Results: The simulation findings illustrate the efficacy of the proposed IoT-CPS-PFEM in identifying the physical fitness levels of athletes, with an average precision of 93%. The method under consideration aims to tackle the existing obstacles of conventional physical fitness assessment techniques, including imprecisions, time lags, and manual data-gathering requirements. The approach of IoT-CPS-PFEM provides the benefits of real-time monitoring, precision, and automation, thereby enhancing an athlete's physical fitness and overall performance to a considerable extent., Conclusion: The research findings suggest that the implementation of IoT-CPS-PFEM can significantly impact the physical fitness of athletes and enhance the performance of the Indian sports industry in global competitions.

Digital well-being records are multimodal and high-dimensional (HD). Better theradiagnostics stem from new computationally thorough and edgy technologies, i.e., hyperspectral (HSI) imaging, super-resolution, and nanoimaging, but advance mess data portrayal and retrieval. A patient's state involves multiple signals, medical imaging (MI) modalities, clinical variables, dialogs between clinicians and patients, metadata, genome sequencing, and signals from wearables. Patients' high volume, personalized data amassed over time have advanced artificial intelligence (AI) models for higher-precision inferences, prognosis, and tracking. AI promises are undeniable, but with slow spreading and adoption, given partly unstable AI model performance after real-world use. The HD data is a rate-limiting factor for AI algorithms generalizing real-world scenarios. This paper studies many health data challenges to robust AI models' growth, aka the dimensionality curse (DC). This paper overviews DC in the MIs' context, tackles the negative out-of-sample influence and stresses important worries for algorithm designers. It is tricky to choose an AI platform and analyze hardships. Automating complex tasks requires more examination. Not all MI problems need automation via DL. AI developers spend most time refining algorithms, and quality data are crucial. Noisy and incomplete data limits AI, requiring time to handle control, integration, and analyses. AI demands data mixing skills absent in regular systems, requiring hardware/software speed and flexible storage. A partner or service can fulfill anomaly detection, predictive analysis, and ensemble modeling.

This paper investigates the attack estimation and state reconstruction problem for linear cyber-physical systems with state delay and simultaneous sensor and actuator attacks. Reduced-order observer is designed for the augmented system to simultaneously estimate the actuator attack, sensor attack and the state of system. By adopting the double integral term into the Lyapunov-Krasovskii functional and decomposing the cross term, the delay-dependent results are obtained. The method proposed in this paper can accurately estimate the state, actuator and sensor attacks simultaneously without additional design. Compared with the previous method, the time delay information is fully utilized and the conservation is greatly reduced. Finally, the correctness of the results is verified by simulation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 ISA. Published by Elsevier Ltd. All rights reserved.)

This article scrutinizes the stabilization and fault reconstruction issues for interval type-2 fuzzy-based cyber-physical systems with actuator faults, deception attacks and external disturbances. The primary objective of this research is to formulate the learning observer system with the interval type-2 fuzzy technique that reconstructs the actuator faults as well as the immeasurable states of the addressed fuzzy based model. Further, the information of reconstructed actuator faults is incorporated in the developed controller with the imperfect premise variables for ensuring the stabilization of the system under consideration. At the same time, the H ∞ technique is employed to reduce the impact of external disturbances in the considered model. In addition to that, the deception attacks are represented as a stochastic variable that satisfies the Bernoulli distributions. On the ground of this, a set of sufficient criteria is deduced in the context of linear matrix inequalities to affirm the stability of the addressed systems. Furthermore, the requisite gain matrices are computed by resolving the obtained linear matrix inequality based stability criteria. At last, two simulation examples, including the mass-spring-damper system are exhibited to demonstrate the usefulness of analytical findings of the developed strategy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 ISA. Published by Elsevier Ltd. All rights reserved.)

The increasing reliance on cyber-physical systems (CPSs) in critical domains such as healthcare, smart grids, and intelligent transportation systems necessitates robust security measures to protect against cyber threats. Among these threats, blackhole and greyhole attacks pose significant risks to the availability and integrity of CPSs. The current detection and mitigation approaches often struggle to accurately differentiate between legitimate and malicious behavior, leading to ineffective protection. This paper introduces Gini-index and blockchain-based Blackhole/Greyhole RPL (GBG-RPL), a novel technique designed for efficient detection and mitigation of blackhole and greyhole attacks in smart health monitoring CPSs. GBG-RPL leverages the analytical prowess of the Gini index and the security advantages of blockchain technology to protect these systems against sophisticated threats. This research not only focuses on identifying anomalous activities but also proposes a resilient framework that ensures the integrity and reliability of the monitored data. GBG-RPL achieves notable improvements as compared to another state-of-the-art technique referred to as BCPS-RPL, including a 7.18% reduction in packet loss ratio, an 11.97% enhancement in residual energy utilization, and a 19.27% decrease in energy consumption. Its security features are also very effective, boasting a 10.65% improvement in attack-detection rate and an 18.88% faster average attack-detection time. GBG-RPL optimizes network management by exhibiting a 21.65% reduction in message overhead and a 28.34% decrease in end-to-end delay, thus showing its potential for enhanced reliability, efficiency, and security.

Cyber-physical systems (CPSs) are monitored and controlled by a computing and communicating core. This cyber layer enables better management of the controlled subsystem, but it also introduces threats to the security and protection of CPSs, as demonstrated by recent cyberattacks. The resulting governance and policy emphasis on cybersecurity is reflected in the academia by a vast body of literature. In this article, we systematize existing knowledge on CPS analysis. Specifically, we focus on the quantitative assessment of CPSs before and after the occurrence of a disruption. Through the systematic analysis of the models and methods adopted in the literature, we develop a CPS resilience assessment framework consisting of three steps, namely, (1) CPS description, (2) disruption scenario identification, and (3) resilience strategy selection. For each step of the framework, we suggest established methods for CPS analysis and suggest four criteria for method selection. The framework proposes a standardized workflow to assess the resilience of CPSs before and after the occurrence of a disruption. The application of the proposed framework is exemplified with reference to a power substation and associated communication network.The case study shows that the proposed framework supports resilience decision making by quantifying the effects of the implementation of resilience strategies., (© 2023 The Authors. Risk Analysis published by Wiley Periodicals LLC on behalf of Society for Risk Analysis.)

The article presents a Cyber-Physical System (CPS) for intelligent management of a poultry farm for broiler meat production, with a fully autonomous microclimate control. Innovative concepts have been introduced for automated management and changing parameters according to pre-set conditions and schedules, with the possibility that the parameters of the algorithm can be further adjusted by the operator. The proposed CPS provides for high productivity with minimal production waste, at optimized costs and with minimization of human errors. The CPS is built on the basis of cost-oriented components. A Raspberry Pi 4 8 GB is used as the server, and the free open-source software OpenHAB 3.0 is used to optimize the cost of building the system as much as possible.

The paper investigates the secure control problems for cyber-physical systems (CPSs) when the transmission channels suffer from Denial-of-Service (DoS) attacks based on switching observer and unknown input reconstruction (UIR). Firstly, an augmented system whose system state consists of the original system state and the measurement noises is set up, and the preconditions for the original system and augmented system are discussed in detail. Secondly, a full-order observer is constructed to generate the estimations of the augmented system state. Besides, based on the state estimation, an algebraic UIR method is developed and the UIR decouples the control input signal successfully. Thirdly, under the situation that some transmission channels suffer from DoS attacks, an observer-based secure controller is designed based on state estimation feedback and UIR feedback in view of a switching system. The stability of the switching system is analyzed as well. Finally, to verify the effectiveness of the proposed protocols, two simulation examples and the comparison with existing methods are given., Competing Interests: Declaration of competing interest We promise that no conflict of interest exists in the submission of this manuscript., (Copyright © 2023 ISA. Published by Elsevier Ltd. All rights reserved.)

The Industrial Internet of Things (IIoT) paradigm is a key research area derived from the Internet of Things (IoT). The emergence of IIoT has enabled a revolution in manufacturing and production, through the employment of various embedded sensing devices connected by an IoT network, along with a collection of enabling technologies, such as artificial intelligence (AI) and edge/fog computing. One of the unrivaled characteristics of IIoT is the inter-connectivity provided to industries; however, this characteristic might open the door for cyber-criminals to launch various attacks. In fact, one of the major challenges hindering the prevalent adoption of the IIoT paradigm is IoT security. Inevitably, there has been an inevitable increase in research proposals over the last decade to overcome these security concerns. To obtain an overview of this research area, conducting a literature survey of the published research is necessary, eliciting the various security requirements and their considerations. This paper provides a literature survey of IIoT security, focused on the period from 2017 to 2023. We identify IIoT security threats and classify them into three categories, based on the IIoT layer they exploit to launch these attacks. Additionally, we characterize the security requirements that these attacks violate. Finally, we highlight how emerging technologies, such as AI and edge/fog computing, can be adopted to address security concerns and enhance IIoT security.

There is a growing body of knowledge on network intrusion detection, and several open data sets with network traffic and cyber-security threats have been released in the past decades. However, many data sets have aged, were not collected in a contemporary industrial communication system, or do not easily support research focusing on distributed anomaly detection. This paper presents the Westermo network traffic data set, 1.8 million network packets recorded in over 90 minutes in a network built up of twelve hardware devices. In addition to the raw data in PCAP format, the data set also contains pre-processed data in the form of network flows in CSV files. This data set can support the research community for topics such as intrusion detection, anomaly detection, misconfiguration detection, distributed or federated artificial intelligence, and attack classification. In particular, we aim to use the data set to continue work on resource-constrained distributed artificial intelligence in edge devices. The data set contains six types of events: harmless SSH, bad SSH, misconfigured IP address, duplicated IP address, port scan, and man in the middle attack., (© 2023 The Authors.)

In the era of interconnected and intelligent cyber-physical systems, preserving privacy has become a paramount concern. This paper aims a groundbreaking proof-of-concept (PoC) design that leverages consortium blockchain technology to address privacy challenges in cyber-physical systems (CPSs). The proposed design introduces a novel approach to safeguarding sensitive information and ensuring data integrity while maintaining a high level of trust among stakeholders. By harnessing the power of consortium blockchain, the design establishes a decentralized and tamper-resistant framework for privacy preservation. However, ensuring the security and privacy of sensitive information within CPSs poses significant challenges. This paper proposes a cutting-edge privacy approach that leverages consortium blockchain technology to secure secrets in CPSs. Consortium blockchain, with its permissioned nature, provides a trusted framework for governing the network and validating transactions. By employing consortium blockchain, secrets in CPSs can be securely stored, shared, and accessed by authorized entities only, mitigating the risks of unauthorized access and data breaches. The proposed approach offers enhanced security, privacy preservation, increased trust and accountability, as well as interoperability and scalability. This paper aims to address the limitations of traditional security mechanisms in CPSs and harness the potential of consortium blockchain to revolutionize the management of secrets, contributing to the advancement of CPS security and privacy. The effectiveness of the design is demonstrated through extensive simulations and performance evaluations. The results indicate that the proposed approach offers significant advancements in privacy protection, paving the way for secure and trustworthy cyber-physical systems in various domains.

Digital Twins serve as virtual counterparts, replicating the characteristics and functionalities of tangible objects, processes, or systems within the digital space, leveraging their capability to simulate and forecast real-world behavior. They have found valuable applications in smart farming, facilitating a comprehensive virtual replica of a farm that encompasses vital aspects such as crop cultivation, soil composition, and prevailing weather conditions. By amalgamating data from diverse sources, including soil, plants condition, environmental sensor networks, meteorological predictions, and high-resolution UAV and Satellite imagery, farmers gain access to dynamic and up-to-date visualization of their agricultural domains empowering them to make well-informed and timely choices concerning critical aspects like efficient irrigation plans, optimal fertilization methods, and effective pest management strategies, enhancing overall farm productivity and sustainability. This research paper aims to present a comprehensive overview of the contemporary state of research on digital twins in smart farming, including crop modelling, precision agriculture, and associated technologies, while exploring their potential applications and their impact on agricultural practices, addressing the challenges and limitations such as data privacy concerns, the need for high-quality data for accurate simulations and predictions, and the complexity of integrating multiple data sources. Lastly, the paper explores the prospects of digital twins in agriculture, highlighting potential avenues for future research and advancement in this domain., Competing Interests: The authors declare no conflict of interest.

The integration of image segmentation technology into packaging style design significantly amplifies both the aesthetic allure and practical utility of product packaging design. However, the conventional image segmentation algorithm necessitates a substantial amount of time for image analysis, rendering it susceptible to the loss of vital image features and yielding unsatisfactory segmentation results. Therefore, this study introduces a novel segmentation network, G-Lite-DeepLabV3+, which is seamlessly incorporated into cyber-physical systems (CPS) to enhance the accuracy and efficiency of product packaging image segmentation. In this research, the feature extraction network of DeepLabV3 is replaced with Mobilenetv2, integrating group convolution and attention mechanisms to proficiently process intricate semantic features and improve the network's responsiveness to valuable characteristics. These adaptations are then deployed within CPS, allowing the G-Lite-DeepLabV3+ network to be seamlessly integrated into the image processing module within CPS. This integration facilitates remote and real-time segmentation of product packaging images in a virtual environment.Experimental findings demonstrate that the G-Lite-DeepLabV3+ network excels at segmenting diverse graphical elements within product packaging images. Compared to the original DeepLabV3+ network, the intersection over union (IoU) metric shows a remarkable increase of 3.1%, while the mean pixel accuracy (mPA) exhibits an impressive improvement of 6.2%. Additionally, the frames per second (FPS) metric experiences a significant boost of 22.1%. When deployed within CPS, the network successfully accomplishes product packaging image segmentation tasks with enhanced efficiency, while maintaining high levels of segmentation accuracy., Competing Interests: The author declares that there are no competing interests., (©2023 Wang.)

"Security by design" is the term for shifting cybersecurity considerations from a system's end users to its engineers. To reduce the end users' workload for addressing security during the systems operation phase, security decisions need to be made during engineering, and in a way that is traceable for third parties. However, engineers of cyber-physical systems (CPSs) or, more specifically, industrial control systems (ICSs) typically neither have the security expertise nor time for security engineering. The security-by-design decisions method presented in this work aims to enable them to identify, make, and substantiate security decisions autonomously. Core features of the method are a set of function-based diagrams as well as libraries of typical functions and their security parameters. The method, implemented as a software demonstrator, is validated in a case study with the specialist for safety-related automation solutions HIMA, and the results show that the method enables engineers to identify and make security decisions they may not have made (consciously) otherwise, and quickly and with little security expertise. The method is also well suited to make security-decision-making knowledge available to less experienced engineers. This means that with the security-by-design decisions method, more people can contribute to a CPS's security by design in less time.

This paper studies the issue of developing the optimal deception attacks on the multiple channels in cyber-physical systems, where the attackers are limited by energy constraints. To fully utilize the eavesdropped data, by linearly combining the innovations from the different channels, a fusion attack model is proposed under the stealthiness condition. According to the statistical characteristics of the correlated stochastic variables and the orthogonality principle, the state estimation error is quantified and analyzed by deriving the iteration of the error covariance matrices of the remote estimators under the proposed attack framework. Moreover, by analyzing the correlations of the decision variables in the objective function, it is shown that the attack parameters and energy allocation strategy can be derived by two steps without loss of optimality, such that the optimal attack scheme is acquired by solving a multivariate semi-definite programming (SDP) problem and a linear 0-1 programming problem respectively. Finally, simulation examples are provided to illustrate the effectiveness of the proposed method., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 ISA. Published by Elsevier Ltd. All rights reserved.)

In the field of artificial intelligence (AI) one of the main challenges today is to make the knowledge acquired when performing a certain task in a given scenario applicable to similar yet different tasks to be performed with a certain degree of precision in other environments. This idea of knowledge portability is of great use in Cyber-Physical Systems (CPS) that face important challenges in terms of reliability and autonomy. This article presents a CPS where unmanned vehicles (drones) are equipped with a reinforcement learning system so they may automatically learn to perform various navigation tasks in environments with physical obstacles. The implemented system is capable of isolating the agents' knowledge and transferring it to other agents that do not have prior knowledge of their environment so they may successfully navigate environments with obstacles. A complete study has been performed to ascertain the degree to which the knowledge obtained by an agent in a scenario may be successfully transferred to other agents in order to perform tasks in other scenarios without prior knowledge of the same, obtaining positive results in terms of the success rate and learning time required to complete the task set in each case. In particular, those two indicators showed better results (higher success rate and lower learning time) with our proposal compared to the baseline in 47 out of the 60 tests conducted (78.3%)., Competing Interests: Juan A. Lara is an Academic Editor for PeerJ., (©2023 Barreiro et al.)

A Cyber-Physical System (CPS) is a network of cyber and physical elements that interact with each other. In recent years, there has been a drastic increase in the utilization of CPSs, which makes their security a challenging problem to address. Intrusion Detection Systems (IDSs) have been used for the detection of intrusions in networks. Recent advancements in the fields of Deep Learning (DL) and Artificial Intelligence (AI) have allowed the development of robust IDS models for the CPS environment. On the other hand, metaheuristic algorithms are used as feature selection models to mitigate the curse of dimensionality. In this background, the current study presents a Sine-Cosine-Adopted African Vultures Optimization with Ensemble Autoencoder-based Intrusion Detection (SCAVO-EAEID) technique to provide cybersecurity in CPS environments. The proposed SCAVO-EAEID algorithm focuses mainly on the identification of intrusions in the CPS platform via Feature Selection (FS) and DL modeling. At the primary level, the SCAVO-EAEID technique employs Z-score normalization as a preprocessing step. In addition, the SCAVO-based Feature Selection (SCAVO-FS) method is derived to elect the optimal feature subsets. An ensemble Deep-Learning-based Long Short-Term Memory-Auto Encoder (LSTM-AE) model is employed for the IDS. Finally, the Root Means Square Propagation (RMSProp) optimizer is used for hyperparameter tuning of the LSTM-AE technique. To demonstrate the remarkable performance of the proposed SCAVO-EAEID technique, the authors used benchmark datasets. The experimental outcomes confirmed the significant performance of the proposed SCAVO-EAEID technique over other approaches with a maximum accuracy of 99.20%.

In this paper, event-triggered output feedback control of a class of high-order nonlinear strict-feedback systems with parametric uncertainties is investigated, in which both of the controller and the parameter estimator are triggered based on a set of event-triggered conditions. Firstly a new one-step control design framework is proposed for the strict-feedback nonlinear systems, therefore both expressions of the controller and the parameter estimate laws are much more simple than those of the recursive design approaches such as backstepping control. Secondly observers are designed to estimate the unknown states, and a set of event-triggering mechanism is proposed for the sensors such that the states are transmitted through the communication network only at the triggering points. The estimated parameter is obtained without real-time integration due to the event-triggered estimator. It is proved that our proposed control law guarantees the closed-loop system is globally bounded and the system output converges to zero asymptotically. It is also proved that the Zeno behavior is excluded. Simulation results demonstrate the effectiveness of the proposed control scheme., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 ISA. Published by Elsevier Ltd. All rights reserved.)

Anomaly detection is essential for realizing modern and secure cyber-physical production systems. By detecting anomalies, there is the possibility to recognize, react early, and in the best case, fix the anomaly to prevent the rise or the carryover of a failure throughout the entire manufacture. While current centralized methods demonstrate good detection abilities, they do not consider the limitations of industrial setups. To address all these constraints, in this study, we introduce an unsupervised, decentralized, and real-time process anomaly detection concept for cyber-physical production systems. We employ several 1D convolutional autoencoders in a sliding window approach to achieve adequate prediction performance and fulfill real-time requirements. To increase the flexibility and meet communication interface and processing constraints in typical cyber-physical production systems, we decentralize the execution of the anomaly detection into each separate cyber-physical system. The installation is fully automated, and no expert knowledge is needed to tackle data-driven limitations. The concept is evaluated in a real industrial cyber-physical production system. The test result confirms that the presented concept can be successfully applied to detect anomalies in all separate processes of each cyber-physical system. Therefore, the concept is promising for decentralized anomaly detection in cyber-physical production systems.

The issue of secure estimation for cyber-physical systems subject to unknown inputs and stealthy deception attacks is addressed in this paper. First, the unknown inputs are treated as augmented state and on the basis of that, the original plant is transformed into a singular system, which is decoupled with the unknown inputs. Then, for the purpose of reducing communication burden and avoiding congestion in the network, the event-triggered mechanism is introduced. Two approaches are presented to accomplish state estimation. The former one is known as the monotone system method. In the latter method, an input-to-state stable robust observer is constructed and by using the set-membership method, approximated estimation error is obtained. Finally, the effectiveness of the proposed method is verified by two illustrative examples., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 ISA. Published by Elsevier Ltd. All rights reserved.)

Stealthy attacks in sensor and actuator loops are the research priorities in the security of cyber-physical systems. Existing attacks define the stealthiness conditions against the Chi-square or Kullback-Leibler divergence detectors and parameterize the attack model based on additive signals. Such conditions ignore the potential anomalies of the vulnerable outputs in the control layer, and the attack sequences need to be generated online, increasing the hardware and software costs. This paper investigates a type of multiplicative attack with essential stealthiness where the employed model is a novel form. The advantage is that the parameters can be designed in a constant form without having to be generated online. An essential stealthiness condition is proposed for the first time and complements the existing ones. Two sufficient conditions for the existence of constant attack matrices are given in the form of theorems, where two methods for decoupling the unknown variables are particularly considered. A quadruple-tank process, an experimental platform for attack and defense, is developed to verify the theoretical results. The experiments indicate that the proposed attack strategy can fulfill both the attack performance and stealthiness conditions.

Phosphorus (P) is a finite resource, and its environmental fate and transport is complex. With fertilizer prices expected to remain high for years and disruption to supply chains, there is a pressing need to recover and reuse P (primarily as fertilizer). Whether recovery is to occur from urban systems (e.g., human urine), agricultural soil (e.g., legacy P), or from contaminated surface waters, quantification of P in various forms is vital. Monitoring systems with embedded near real time decision support, so called cyber physical systems, are likely to play a major role in the management of P throughout agro-ecosystems. Data on P flow(s) connects the environmental, economic, and social pillars of the triple bottom line (TBL) sustainabilty framework. Emerging monitoring systems must account for complex interactions in the sample, and interface with a dynamic decision support system that considers adaptive dynamics to societal needs. It is known from decades of study that P is ubiquitous, yet without quantitative tools for studying the dynamic nature of P in the environment, the details may remain elusive. If new monitoring systems (including CPS and mobile sensors) are informed by sustainability frameworks, data-informed decision making may foster resource recovery and environmental stewardship from technology users to policymakers., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 Published by Elsevier Ltd.)

Streets perform a number of important functions and have a wide range of activities performed in them. There is a small but growing focus on streets as a more generalisable, atomised, and therefore more manageable unit of development and analysis than cities. Despite the public realm being one of the largest physical spaces on streets, the impact and potential of digitalisation projects on this realm is rarely considered. In this article, the smartness of a street is derived from the cyber-physical social infrastructure in the public realm, including data obtained from sensors, the interconnection between different services, technologies and social actors, intelligence derived from analysis of the data, and optimisation of operations within a street. This article conceptualises smart streets as basic units of urban space that leverage cyber-physical social infrastructure to provide and enable enhanced services to and between stakeholders, and through stakeholders' use of the street, generate data to optimise its services, capabilities, and value to stakeholders. A proposed conceptual framework is used to identify and explore how streets can be augmented and create value through cyber-physical social infrastructure and digital enhancements. We conclude with a discussion of future avenues of research.

The package design can transmit the value of a product to consumers visually and can therefore influence the consumers' decisions. The traditional package design is an open-loop process in which a design can only be evaluated after the products are sent to the market. Thus, the designers cannot refine the design without any helpful advice. In this paper, a robust robot image classification is proposed to help the designers to evaluate their package design and improve their design in a closed-loop process, which is essentially the establishment of a cyber-physical system for the package design. The robust robot image classification adopts the total variation regularization, which ensures that the proposed robot image classification can give the right answers even if it is trained by noisy labels. The robustness against noisy labels is emphasized here since the historical data set of package design evaluations may have some false labels that can be equivalently regarded as disturbed labels from the true labels by noises. To validate the effectiveness of the proposed robot image classification method, experimental data-based validations have been implemented. The results show that the proposed method exhibits much better accuracy in classification compared to the traditional training method when noisy labels are used for the training process., Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Liu.)

Smart factories are complex; with the increased complexity of employed cyber-physical systems, the complexity evolves further. Cyber-physical systems produce high amounts of data that are hard to capture and challenging to analyze. Real-time recording of all data is not possible due to limited network capabilities. Limited network capabilities are the reason for a chain of faults introduced via active surveillance during fault diagnosis. These introduced faults may slow down production or lead to an outage of the production line. Here, we present a novel approach to automatically select production-relevant shop floor parameters to decrease the number of surveyed variables and, at the same time, maintain quality in fault diagnosis without overloading the network. We were able to achieve higher throughput, mitigate communication losses and prevent the disruption of factory instructions. Our approach uses an autoencoder ensemble via minority voting to differentiate between normal-always on-variables and production variables that may yield a higher entropy. Our approach has been tested in a production-equal smart factory and was cross-validated by a domain expert.

Deep Reinforcement Learning (DRL) is increasingly applied in cyber-physical systems for automation tasks. It is important to record the developing trends in DRL's applications to help researchers overcome common problems using common solutions. This survey investigates trends seen within two applied settings: motor control tasks, and resource allocation tasks. The common problems include intractability of the action space, or state space, as well as hurdles associated with the prohibitive cost of training systems from scratch in the real-world. Real-world training data is sparse and difficult to derive and training in real-world can damage real-world learning systems. Researchers have provided a set of common as well as unique solutions. Tackling the problem of intractability, researchers have succeeded in guiding network training with handcrafted reward functions, auxiliary learning, and by simplifying the state or action spaces before performing transfer learning to more complex systems. Many state-of-the-art algorithms reformulate problems to use multi-agent or hierarchical learning to reduce the intractability of the state or action spaces for a single agent. Common solutions to the prohibitive cost of training include using benchmarks and simulations. This requires a shared feature space common to both simulation and the real world; without that you introduce what is known as the reality gap problem. This is the first survey, to our knowledge, that studies DRL as it is applied in the real world at this scope. It is our hope that the common solutions surveyed become common practice., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

A digital twin is a virtual model of a process, product, or service, which is one of the key technologies in the fourth industry. The pairing of the virtual and physical world allows analysis of data and monitoring of systems to head off problems before they occur. This paper presents a digital twin architecture and a system based on an interoperable data model. It explains how to build a digital twin for the integrated control monitoring using edge devices, data analytics, and realistic 3D visualization. The system allows continuous collaboration between field engineers for data gathering, designers for modeling 3D models, and layout engineers for layout changing by generating 3D digital twin models automatically. The system helps stakeholders focus on their respective roles to build digital twins. Examples applied to the Korean automotive parts makers are also introduced in this paper. The system can be easily used by small and medium-sized enterprises (SMEs) as well as large companies. Beyond simply watching the production site with CCTV, the production site can be intuitively managed based on the digital twin.

The System of Cyber-Physical Systems (SoCPS) comprises several independent Cyber-Physical Systems (CPSs) that interact with each other to achieve a common mission that the individual systems cannot achieve on their own. SoCPS are rapidly gaining attention in various domains, e.g., manufacturing, automotive, avionics, healthcare, transportation, and more. SoCPS are extremely large, complex, and safety-critical. As these systems are safety-critical in nature, it is necessary to provide an adequate safety analysis mechanism for these collaborative SoCPS so that the whole network of these CPSs work safely. This safety mechanism must include composite safety analysis for a network of collaborative CPS as a whole. However, existing safety analysis techniques are not built for analyzing safety for dynamically forming networks of CPS. This paper introduces a composite safety analysis approach called SafeSoCPS to analyze hazards for a network of SoCPS. In SafeSoCPS, we analyze potential hazards for the whole network of CPS and trace the faults among participating systems through a fault propagation graph. We developed a tool called SoCPSTracer to support the SafeSoCPS approach. Human Rescue Robot System-a collaborative system-is taken as a case study to validate our proposed approach. The result shows that the SafeSoCPS approach enables us to identify 18 percent more general faults and 63 percent more interaction-related faults in a network of a SoCPS.

The proliferation of low-cost Internet of Things (IoT) devices has led to a race between wireless security and channel attacks. Traditional cryptography requires high computational power and is not suitable for low-power IoT scenarios. Whilst recently developed physical layer security (PLS) can exploit common wireless channel state information (CSI), its sensitivity to channel estimation makes them vulnerable to attacks. In this work, we exploit an alternative common physics shared between IoT transceivers: the monitored channel-irrelevant physical networked dynamics (e.g., water/oil/gas/electrical signal-flows). Leveraging this, we propose, for the first time, graph layer security (GLS), by exploiting the dependency in physical dynamics among network nodes for information encryption and decryption. A graph Fourier transform (GFT) operator is used to characterise such dependency into a graph-bandlimited subspace, which allows the generation of channel-irrelevant cipher keys by maximising the secrecy rate. We evaluate our GLS against designed active and passive attackers, using IEEE 39-Bus system. Results demonstrate that GLS is not reliant on wireless CSI, and can combat attackers that have partial networked dynamic knowledge (realistic access to full dynamic and critical nodes remains challenging). We believe this novel GLS has widespread applicability in secure health monitoring and for digital twins in adversarial radio environments.

Lies and disinformation have always existed throughout human history. However, disinformation has become a "pandemic within a pandemic" with convergence of COVID-19 and digital transformation of health care, climate emergency, and pervasive human-computer interaction in all facets of life. We are living through an era of post-truth. New approaches to fight disinformation are urgently needed and of paramount importance for systems science and planetary health. In this study, we discuss the ways in which extractive and entrenched epistemologies such as technocracy and neoliberalism co-produce disinformation. We draw from the works of David Collingridge in technology entrenchment and the literature on digital health, international affairs, climate emergency, degrowth, and decolonializing methodologies. We expand the vocabulary on and interventions against disinformation, and propose the following: (1) rapid epistemic disobedience as a critical governance tool to resist the cultural hegemony of neoliberalism and its master narrative infinite growth that is damaging the planetary ecosystems, while creating echo chambers overflowing with disinformation, and (2) a two-tiered taxonomy of reflexivity , a state of self-cognizance by knowledge actors, for example, scientists, engineers, and physicians (type 1 reflexivity), as well as by chroniclers of former actors, for example, civil society organizations, journalists, social sciences, and humanities scholars (type 2 reflexivity). This article takes seriously the role of master narratives in quotidian life in production of disinformation and ecological breakdown. The infinite growth narrative does not ask critical questions such as "growth in what, at what costs to society and environment?," and is a dangerous game of brinkmanship that has been testing the planetary ecological boundaries and putting at risk the veracity of knowledge. There is a need for scholars and systems scientists who break ranks with entrenched narratives that pose existential threats to planetary sustainability and are harmful to knowledge veracity. Scholars who resist the obvious recklessness and juggernaut of the pursuit of neoliberal infinite growth would be rooting for living responsibly and in solidarity on a planet with finite resources. The interventions proposed in this study, rapid epistemic disobedience and the expanded reflexivity taxonomy, can advance progressive policies for a good life for all within planetary boundaries, and decolonize knowledge from disinformation in ways that are necessarily upstream, radical, rapid, and emancipatory.

Human Machine Interfaces (HMI) principles are for the development of interfaces for assistance or support systems in physiotherapy or rehabilitation processes. One of the main problems is the degree of customization when applying some rehabilitation therapy or when adapting an assistance system to the individual characteristics of the users. To solve this inconvenience, it is proposed to implement a database of surface Electromyography (sEMG) of a channel in healthy individuals for pattern recognition through Neural Networks of contraction in the muscular region of the biceps brachii. Each movement is labeled using the One-Hot Encoding technique, which activates a state machine to control the position of an anthropomorphic manipulator robot and validate the response time of the designed HMI. Preliminary results show that the learning curve decreases when customizing the interface. The developed system uses muscle contraction to direct the position of the end effector of a virtual robot. The classification of Electromyography (EMG) signals is obtained to generate trajectories in real time by designing a test platform in LabVIEW.

The main impetus for the global efforts toward the current digital transformation in almost all areas of our daily lives is due to the great successes of artificial intelligence (AI), and in particular, the workhorse of AI, statistical machine learning (ML). The intelligent analysis, modeling, and management of agricultural and forest ecosystems, and of the use and protection of soils, already play important roles in securing our planet for future generations and will become irreplaceable in the future. Technical solutions must encompass the entire agricultural and forestry value chain. The process of digital transformation is supported by cyber-physical systems enabled by advances in ML, the availability of big data and increasing computing power. For certain tasks, algorithms today achieve performances that exceed human levels. The challenge is to use multimodal information fusion, i.e., to integrate data from different sources (sensor data, images, *omics), and explain to an expert why a certain result was achieved. However, ML models often react to even small changes, and disturbances can have dramatic effects on their results. Therefore, the use of AI in areas that matter to human life (agriculture, forestry, climate, health, etc.) has led to an increased need for trustworthy AI with two main components: explainability and robustness. One step toward making AI more robust is to leverage expert knowledge. For example, a farmer/forester in the loop can often bring in experience and conceptual understanding to the AI pipeline-no AI can do this. Consequently, human-centered AI (HCAI) is a combination of "artificial intelligence" and "natural intelligence" to empower, amplify, and augment human performance, rather than replace people. To achieve practical success of HCAI in agriculture and forestry, this article identifies three important frontier research areas: (1) intelligent information fusion; (2) robotics and embodied intelligence; and (3) augmentation, explanation, and verification for trusted decision support. This goal will also require an agile, human-centered design approach for three generations (G). G1: Enabling easily realizable applications through immediate deployment of existing technology. G2: Medium-term modification of existing technology. G3: Advanced adaptation and evolution beyond state-of-the-art.

Because of the complex production processes and technology-intensive operations that take place in the aerospace and defense industry, introducing Industry 4.0 into the manufacturing processes of aircraft composite materials is inevitable. Digital Twin and Cyber-Physical Systems in Industry 4.0 are key techniques to develop digital manufacturing. Since it is very difficult to create high-fidelity virtual models, the development of digital manufacturing for aircraft manufacturers is challenging. In this study, we provide a view from a data simulation perspective and adopt machine learning approaches to simplify the high-fidelity virtual models in Digital Twin. The novel concept is called Data Twin, and the deployable service to support the simulation is known as the Data Twin Service (DTS). Relying on the DTS, we also propose a microservice software architecture, Cyber-Physical Factory (CPF), to simulate the shop floor environment. Additionally, there are two war rooms in the CPF that can be used to establish a collaborative platform: one is the Physical War Room, used to integrate real data, and the other is the Cyber War Room for handling simulation data and the results of the CPF.

The increase of productivity and decrease of production loss is an important goal for modern industry to stay economically competitive. For that, efficient fault management and quick amendment of faults in production lines are needed. The prioritization of faults accelerates the fault amendment process but depends on preceding fault detection and classification. Data-driven methods can support fault management. The increasing usage of sensors to monitor machine health status in production lines leads to large amounts of data and high complexity. Machine Learning methods exploit this data to support fault management. This paper reviews literature that presents methods for several steps of fault management and provides an overview of requirements for fault handling and methods for fault detection, fault classification, and fault prioritization, as well as their prerequisites. The paper shows that fault prioritization lacks research about available learning methods and underlines that expert opinions are needed.

Artificial Intelligence (AI) in Cyber-Physical Systems allows machine learning inference on acquired data with ever greater accuracy, thanks to models trained with massive amounts of information generated by Internet of Things devices. Edge Intelligence is increasingly adopted to execute inference on data at the border of local networks, exploiting models trained in the Cloud. However, the training tasks on Edge nodes are not supported yet with flexible dynamic migration between Edge and Cloud. This paper proposes a Cloud-Edge AI microservice architecture, based on Osmotic Computing principles. Notable features include: (i) containerized architecture enabling training and inference on the Edge, Cloud, or both, exploiting computational resources opportunistically to reach the best prediction accuracy; and (ii) microservice encapsulation of each architectural module, allowing a direct mapping with Commercial-Off-The-Shelf (COTS) components. Grounding on the proposed architecture: (i) a prototype has been realized with commodity hardware leveraging open-source software technologies; and (ii) it has been then used in a small-scale intelligent manufacturing case study, carrying out experiments. The obtained results validate the feasibility and key benefits of the approach.