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Objectives: To investigate the chemical and mechanical properties of polyphenylene sulfone (PPSU) depending on its composition and manufacturing., Methods: Unfilled-PPSU1 and with antimicrobial silver coated zeolites filled-PPSU2 specimens were made of granulate-GR, filament-FI, or printed-3D. Scanning microscopy and X-ray spectroscopy were performed. Martens hardness-HM, elastic indentation modulus-E IT and flexural strength-FS were determined initially and after aging. Shear bond strength-SBS to veneering and luting composite after conditioning with 7 adhesive systems were examined after aging. Silver leaching was tested after 1-, 3-, 7-, 14-, 21-, 28- and 42 days. Analyses of variance, Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U, unpaired t-tests and Weibull modulus were computed (p < 0.05)., Results: Zeolites were homogeneously distributed. PPSU1-GR and PPSU1-FI showed the highest HM/E IT , followed by PPSU2-GR, PPSU1-3D and PPSU2-3D. PPSU2-FI presented the lowest HM/E IT , displaying micro pits. Aging showed reduced HM/E IT in PPSU1 and no impact on PPSU2, while FS increased (PPSU1) or decreased (PPSU2). PPSU2-3D presented lower FS than PPSU1-3D. High SBS to the luting (7.0-16.2 MPa) and veneering composite (11.8-22.2 MPa), except for adhesive system PR, were observed. PPSU2-3D showed the highest silver release (9.6%), with all compositions dispensing silver over 42 days., Conclusions: For the examined period of 6 weeks, antimicrobial silver ions were released from filled PPSU. The high SBS between PPSU and veneering/luting composite confirmed the feasibility of esthetically veneering and luting filled PPSU. To achieve mechanical properties like unfilled PPSU, the processing parameters of filled PPSU require refinement., Clinical Significance: This investigation provides proof of principle that PPSU can be successfully doped with silver-coated zeolites. The combination of 3D-printing with an antimicrobial thermoplastic constitutes a great opportunity in the field of prosthetic dentistry. Potential applications include clasps for removable dental prostheses, provisional or permanent fixed dental prostheses and implant abutments., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The global searchlight for sustainable alternative fuels to reduce emissions produced from the combustion of fossil fuels illuminates biofuels owing to their matching properties with fossil fuels. This is the impetus for this study which systematically examines the impact of neem biodiesel (NB) blends with pure diesel on the physical and chemical properties of particulate matter (PM) from diesel engines. Pure diesel (B0) and four fuel blends, namely, B5, B10, B15 and B20 are examined. The impact of NB blends on the physical and chemical properties of PM is studied using a single-cylinder, 4-stroke diesel engine. The PM captured directly from the diesel engine at two standard engine speeds is analyzed by physical microscopy techniques and chemical analyses. Comparing the results of gaseous emissions for B0 with those of B20, it is found that B20 decreases CO by 9.6% and 19.3% at low and high engine speeds, respectively, but increases NO X . Regarding PM emission, in comparison to B0, B20 decreases particle sizes from 59.4 ± 8.5 nm to 42.8 ± 4.2 nm and 63.3 ± 8.1 nm to 43.7 ± 5.2 nm; opacities from 15.9% to 9.3% and 21.1%-11.4%; carbon contents from 66.53% to 44.53% and 72.53%-61.99%; and total carbon concentrations (total organic carbon and total inorganic carbon) from 3.6120 mg/L to 1.8435 mg/L and 2.5970 mg/L to 1.6002 mg/L at low and high engine speeds, respectively. Furthermore, B20 increases the unused oxygen content from 14.07% to 21.47% and 16.82%-18.42%; oxygen reactivity from 1.80 ± 0.08 to 2.75 ± 0.18 and 1.10 ± 0.20 to 1.35 ± 0.06; and volatile substances by 68.4% and 57.1% at low and high engine speeds, respectively. This study demonstrates that NB could be a potential alternative fuel for diesel engines regarding PM emissions, where B20 blend has the highest impact on PM properties, but it needs additional NOx mitigation strategies., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Prof. Pak Kin Wong reports financial support was provided by University of Macau. Prof. Pak Kin Wong reports a relationship with University of Macau that includes: employment and funding grants. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Ethnopharmacologic Relevance: The leaves of Nelumbo nucifera Gaertn. Are recorded in the earliest written documentation of traditional Chinese medicinal as "Ben Cao Gang Mu", a medicinal herb for blood clotting, dysentery and dizziness. Nuciferine, one of N. nucifera Gaertn. leaf extracts, has been shown to possess several pharmacological properties, including but not limited to ameliorating hyperlipidemia, stimulating insulin secretion, inducing vasodilation, reducing blood pressure, and demonstrating anti-arrhythmic properties., Aim of the Study: In light of the latest research findings on nuciferine, this article provides a comprehensive overview of its chemical properties, pharmacological activities, and the underlying regulatory mechanisms. It aims to serve as a dependable reference for further investigations into the pharmacological effects and mechanisms of nuciferine., Materials and Methods: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the literature on extraction, separation, structural analysis and pharmacological activity of nuciferine published before November 2023. The key words are "extraction", "isolation", "purification" and "pharmacological action" and "nuciferine"., Results: Nuciferine has been widely used in the treatment of ameliorating hyperlipidemia and lose weight, Nuciferine is a monomeric aporphine alkaloid extracted from the leaves of the plant Nymphaea caerulea and Nelumbo nucifera Gaertn. Nuciferine has pharmacological activities such as relaxing smooth muscles, improving hyperlipidemia, stimulating insulin secretion, vasodilation, inducing hypotension, antiarrhythmic effects, and antimicrobial and anti-HIV activities. These pharmacological properties lay a foundation for the treatment of tumors, inflammation, hyperglycemia, lipid-lowering and weight-loss, oxidative stress and other diseases with nuciferine., Conclusion: Nuciferine has been clinically used to treat hyperlipidemia and aid in weight loss due to its effects on lipid levels, insulin secretion, vasodilation, blood pressure reduction, anti-tumor properties, and immune enhancement. However, other potential benefits of nuciferine have not yet been fully explored in clinical practice. Future research should delve deeper into its molecular structure, toxicity, side effects, and clinical pharmacology to uncover its full range of effects and pave the way for its safe and expanded clinical use., Competing Interests: Declaration of competing interest I am authorized on behalf of all the authors of this article to confirm that no author has any conflict of interest to disclose, all authors have approved the version submitted for publication, the work in this article is original and has not been published previously, and the article is not under consideration by any other journal. We thank you for your kind consideration of our article. Please do not hesitate to contact me directly if any further information is required. I look forward to hearing from you., (Copyright © 2024 Elsevier B.V. All rights reserved.)

COVID-19, a novel ailment, has received comparatively fewer drugs for its treatment. Side Effects (SE) of a COVID-19 drug could cause long-term health issues. Hence, SE prediction is essential in COVID-19 drug development. Efficient models are also needed to predict COVID-19 drug SE since most existing research has proposed many classifiers to predict SE for diseases other than COVID-19. This work proposes a novel classifier based on neighbors named K 1 K 2 Nearest Neighbors (K 1 K 2 NN) to predict the SE of the COVID-19 drug from 17 molecules' descriptors and the chemical 1D structure of the drugs. The model is implemented based on the proposition that chemically similar drugs may be assigned similar drug SE, and co-occurring SE may be assigned to chemically similar drugs. The K 1 K 2 NN model chooses the first K 1 neighbors to the test drug sample by calculating its similarity with the train drug samples. It then assigns the test sample with the SE label having the majority count on the SE labels of these K 1 neighbor drugs obtained through a voting mechanism. The model then calculates the SE-SE similarity using the Jaccard similarity measure from the SE co-occurrence values. Finally, the model chooses the most similar K 2 SE neighbors for those SE determined by the K 1 neighbor drugs and assigns these SE to that test drug sample. The proposed K 1 K 2 NN model has showcased promising performance with the highest accuracy of 97.53% on chemical 1D drug structure and outperforms the state-of-the-art multi-label classifiers. In addition, we demonstrate the successful application of the proposed model on gene expression signature datasets, which aided in evaluating its performance and confirming its accuracy and robustness., Competing Interests: Declaration of Competing Interest We know that no conflicts of interest associated with this publication, and there has been no significant financial support for this work that could have influenced its outcome., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Geopolymers are amorphous aluminosilicate inorganic polymers synthesized by alkaline activation characterized by a lower carbon footprint, greater durability, and excellent mechanical properties compared to traditional concrete, making them promising building materials for sustainable construction. To develop sustainable lightweight geopolymer-based building materials useful as fire resistant thermal insulation materials, we added 5 and 10 wt% of discarded cork dust, a readily available industrial by-product, to metakaolin before and after the alkaline activation with sodium hydroxide 8 M and sodium silicate solutions. We followed the chemical, microstructural, antibacterial, and physical properties of the resulting composites for up to 90 days in order to monitor their long-term durability. The presence of cork does not interfere with the geopolymerization process and in fact reduces the density of the composites to values around 2.5 g/cm 3 , especially when added after alkaline activation. The composites resulted in chemically stable matrices (less than 10 ppm of cations release) and filler (no hazardous compounds released) with a bacterial viability of around 80%. This study provides valuable insights into the tailoring of discarded cork-based composites obtained by geopolymerization with a porosity between 32 and 48% and a mechanical resistance to compression from 15 to 5 MPa, respectively, suggesting their potential as durable interior panels with low environmental impact and desirable performance., (© 2024. The Author(s).)

This study describes the development and evaluation of six new models for predicting physical-chemical (PC) properties that are highly relevant for chemical hazard, exposure, and risk estimation: solubility (in water S W and octanol S O ), vapor pressure (VP), and the octanol-water (K OW ), octanol-air (K OA ), and air-water (K AW ) partition ratios. The models are implemented in the Iterative Fragment Selection Quantitative Structure-Activity Relationship (IFSQSAR) python package, Version 1.1.0. These models are implemented as Poly-Parameter Linear Free Energy Relationship (PPLFER) equations which combine experimentally calibrated system parameters and solute descriptors predicted with QSPRs. Two other ancillary models have been developed and implemented, a QSPR for Molar Volume (MV) and a classifier for the physical state of chemicals at room temperature. The IFSQSAR methods for characterizing applicability domain (AD) and calculating uncertainty estimates expressed as 95% prediction intervals (PI) for predicted properties are described and tested on 9,000 measured partition ratios and 4,000 VP and S W values. The measured data are external to IFSQSAR training and validation datasets and are used to assess the predictivity of the models for "novel chemicals" in an unbiased manner. The 95% PI intervals calculated from validation datasets for partition ratios needed to be scaled by a factor of 1.25 to capture 95% of the external data. Predictions for VP and S W are more uncertain, primarily due to the challenges in differentiating their physical state (i.e., liquids or solids) at room temperature. The prediction accuracy of the models for log K OW , log K AW and log K OA of novel, data-poor chemicals is estimated to be in the range of 0.7 to 1.4 root mean squared error of prediction (RMSEP), with RMSEP in the range 1.7-1.8 for log VP and log S W . Scientific contributionNew partitioning models integrate empirical PPLFER equations and QSARs, allowing for seamless integration of experimental data and model predictions. This work tests the real predictivity of the models for novel chemicals which are not in the model training or external validation datasets., (© 2024. The Author(s).)

Natural fibres have attracted more attention compared with synthetic fibre because they exhibit several benefits over synthetic fibre, such as being cost-effective, readily available, and lightweight apart from offering better mechanical properties. Corn husk fibres being a natural crop fibre have attracted more attention due to their renewability and biodegradability. Corn husk is an outer protective layer of maize which is generally discarded as waste. However, this agro-waste can be utilized exclusively for various applications with a sustainable approach by extracting fibres out of them. This paper aims to revolutionize the usage of corn husk fibres in conventional as well as technical textile industries by enlisting various application areas. A comprehensive understanding of corn husk fibre extraction techniques and their effect on various fibre properties are also discussed. These properties are compared with properties of other natural fibres, to enable the possibility of converting corn husk fibres into different textile forms such as yarn, woven and nonwoven fabric, and composites. This will fulfill the increasing demand for natural fibre along with biodegradability and reduced petroleum dependency while contributing to the purpose-driven use of agro waste., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Purpose: The large-scale planting of potatoes leads to soil degradation, thus limiting the potato yield. An effective method of improving soil quality involves the combined application of biochar and organic fertilizer. However, the proportion of biochar and organic fertilizer at which potato yield can be improved, as well as the improvement mechanism, remain unclear., Methods: A combined application experiment involving biochar (B) and organic fertilizer (O) with four concentration gradients was conducted using the equal carbon ratio method. On this basis, rhizosphere soil fertility, bacterial community composition, and bacterial diversity in potato crops, as well as the potato yield difference under different combined application ratios, were investigated. Then, the direct and indirect effects of these factors on potato yield were analyzed., Results: The results suggest that soil fertility was improved by the combined application of biochar and organic fertilizer, with the best effect being achieved at a ratio of B:O=1:2. The dominant bacterial communities in the potato rhizosphere included Proteobacteria , Actinobacteria , Gemmatimonadetes , Chloroflexi , and Bacteroidetes . When compared to the control, the relative abundance and diversity index of soil bacteria were significantly improved by the treatment at B:O=1:2, which exerted a stronger effect on improving the relative abundance of beneficial bacteria. Soil available phosphorus (AP), soil pH (SpH), and soil organic carbon (SOC) explained 47.52% of the variation in bacterial composition. Among them, the main factor was the content of soil available nutrients, while SpH generated the weakest effect. The bacterial diversity index showed a significant positive correlation with soil AP, SOC, available potassium (AK), total nitrogen (TN), and C/N ratio, and a significant negative correlation with SpH. Bacterial diversity directly affected the potato yield, while soil fertility indirectly affected potato yield by influencing the soil bacterial diversity., Conclusion: The combined application of biochar and organic fertilizer elevates potato yield mainly by improving the diversity of bacterial communities in potato rhizosphere soil, especially the combined application of biochar and organic fertilizer at a 1:2 ratio (biochar 0.66 t ha -1 +organic fertilizer 4.46 t ha -1 ), which made the largest contribution to increasing potato yield., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Hou, Xing, Zhang, Wang, Liu, Duan and Zhao.)

Pectin was extracted from Actinidia arguta Sieb. et Zucc ( A.arguta ) using the ultrasound-assisted acid method and the single acid method. The physicochemical properties, structure, and antioxidant properties of two different pectins were investigated. The results showed that the extraction yield of the ultrasound-assisted acid method is higher than that of the single acid method. The molecular structure of A. arguta pectin extracted by the ultrasound-assisted acid method belongs to a mixed structure of RG-I and HG-type domains. Through structural feature analysis, the ultrasound-assisted extraction pectin (UAP) has a more branched structure than the single acid-extracted pectin (SAP). The SAP has a higher degree of esterification than the UAP. The physical property results show that the viscosity, solubility, and water-holding capacity of the UAP are better than those of the SAP. The antioxidant test results show that the hydroxyl radical scavenging and reducing powers of the UAP are superior to those of the SAP. This study shows the composition, physicochemical properties, and antioxidant activity of A. arguta pectin extracted by the ultrasonic-assisted extraction method to provide a theoretical basis for its application as an antioxidant and other food additives in the food industry., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Liu, Sui, Wang, Li, Chen and Shi.)

This study was initiated to determine the quality of fresh and used oil for street vendor fried food products in Harar City, Ethiopia. Using a purposive sample technique, 12 respondents were selected for the study. The study obtained a total of 12 oil samples, categorized as fresh, in-use, and discarded, from two distinct groups of respondents. Specifically, six samples were collected from vendors utilizing an electric fryer constructed from stainless steel, while the remaining six samples were acquired from vendors employing a pan heated by wood or charcoal.The moisture content of fresh, in-use, and discarded oil samples, among other physical characteristics of the samples obtained from two types of vendors, was examined and found to vary between 0.14 and 0.44%, 0.19 and 0.52%, and 0.25 and 0.75%, respectively. Comparably, the refractive indices of oil samples that were fresh, in use, and discarded were 1.4595-1.4686, 1.4670-1.4885, and 1.4810-1.4960, in that order. Furthermore, the ranges of viscosities for fresh oil, oil samples in use, and oil samples that were discarded were 57.15-76.94, 100-196.50, and 210.22-288.50 mPa, respectively. Chemical properties, including % free fatty acid for similar samples, range from 0.22 to 1.30, 1.12 2.54, and 1.38-3.66%, respectively. Peroxide values of fresh, in-use, and discarded oil samples, have a maximum value of 11.19 meq/kg, 42.90, and 57.60 meq/kg, respectively. The iodine value showed the highest value for the fresh oil sample, while the minimum was obtained under discarded oil sample. The result indicated that they used low-quality oil. The values obtained after frying for samples collected from vendors who used a pan fryer heated with charcoal or wood fire deviated significantly from the requirements, indicating that the palm oil used by those street vendors was unsafe to consume because it could endanger the consumers' health., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

This study evaluated the influence of starch-protein interactions on the chemical properties and digestibility of a 3D-printed gel based on salmon by-product protein. Changes in the starch-protein interactions of the stable cornstarch (CS, 15%) and salmon protein isolate (SPI, 4%-12%) printable gels during the in vitro gastrointestinal digestion process were studied by principal component analysis. Protein-rich printed gels increased resistant starch content by 18.05%. Changes in chemical properties and the starch-protein concentration of the gels during the digestion process were highly correlated. The CS-SPI gels in the gastric and intestinal phases exhibited lower α-helix/β-sheet ratio and fluorescence intensity values, whereas surface hydrophobicity increased. This resulted in more ordered structures with a high level of molecular interaction that inhibited enzymatic hydrolysis. This study provides crucial information about the transformations of starch-protein interactions during the digestibility of 3D-printed food matrices as an alternative source of nutrients with a high nutritional quality., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The aging process can affect the physical and chemical properties as well as adsorption capacity of biochar. This study focuses on the heavy metal cadmium (Cd) as the research object, and artificially ages biochar prepared from rice straw and corn straw through accelerated freeze-thaw cycles, alternating dry wet cycles, and ultraviolet light treatment, in order to evaluate the effects of different aging conditions on the physical and chemical properties of the two different types of biochar and on their adsorption capacities for Cd. After aging, the pH of rice and corn biochar decreased to varying degrees, respectively. The surface structure was ruptured, the average pore diameter was decreased, and the specific surface area was increased by 27.3%, 21.9%, and 9.8% (rice) and 95.4%, 27.7%, and 13.4% (corn). Ultraviolet light aging has the most significant impact on the elemental content of biochar, and the C content was decreased by 12.4% (rice) and 9.3% (corn). The O content was increased by 11.2% (rice) and 44.1% (corn), and the numbers of O/C, H/C, (O + N)/C, and oxygen-containing functional groups were increased. These results demonstrate that the aging process reduces the degree of aromatization of biochar, while enhancing its polarity and Cd adsorption capacity. Rice straw biochar (RSB) has a greater ability to adsorb Cd than corn straw biochar (CSB). In addition, ultraviolet light aging is particularly effective in increasing heavy metal adsorption., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Foeniculum vulgare Mill. is a medicinal and food homologous plant, and it has various biological activities. Yet, no research has explored its anti-motion sickness effects. Chemical properties of fennel extracts (FvE) and flavonoids (Fvf) were analyzed based on UPLC-QTRAP-MS to elucidate its potential anti-motion sickness components in the present study. The mice models of motion sickness were stimulated by biaxial rotational acceleration. Behavioral experiments such as motion sickness index and open field test and the measurement of neurotransmitters were used to evaluate the efficacy of compounds on motion sickness. Results showed that FvE contains terpenes, alkaloids, flavonoids, etc. Eight flavonoids including quercetin-3β-D-glucoside, rutin, hyperoside, quercetin, miquelianin, trifolin, isorhamnetin and kaempferol were identified in the purified Fvf. FvE and Fvf significantly reduced the motion sickness index of mice by 53.2% and 48.9%, respectively. Fvf also significantly alleviated the anxious behavior of mice after rotational stimulation. Among the eight flavonoids, isorhamnetin had the highest oral bioavailability and moderate drug-likeness index and thus speculated to be the bioactive compound in fennel for its anti-motion sickness effect. It reduced the release of 5-HT and Ach to alleviate the motion sickness response and improve the work completing ability of mice and nervous system dysfunction after rotational stimulation. This study provided in-depth understanding of the anti-motion sickness bioactive chemical properties of fennel and its flavonoids, which will contribute to the new development and utilization of fennel., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The Asian water plantain, Alisma orientale (Sam.) Juzep, is a traditional Chinese medicinal plant. The dried tubers of the Alisma orientale , commonly referred to as Alismatis rhizome (AR), have long been used in traditional Chinese medicine to treat a variety of diseases. Soil properties and the soil microbial composition are known to affect the quality and bioactivity of plants. Here, we sought to identify variations in soil fungal communities and soil properties to determine which would be optimal for cultivation of A. orietale . Soil properties, heavy metal content, and pesticide residues were determined from soils derived from four different agricultural regions around Shaowu City, Fujian, China, that had previously been cultivated with various crops, namely, Shui Dao Tu (SDT, rice), Guo Shu Tu (GST, pecan), Cha Shu Tu (CST, tea trees), and Sang Shen Tu (SST, mulberry). As fungi can either positively or negatively impact plant growth, the fungal communities in the different soils were characterized using long-read PacBio sequencing. Finally, we examined the quality of A. orientale grown in the different soils. Our results show that fungal community diversity of the GST soil was the highest with saprotrophs the main functional modes in these and SDT soils. Our data show that GST and SDT soils were most suitable for A. orientale growth, with the quality of the AR tubers harvested from GST soil being the highest. These data provide a systematic approach at soil properties of agricultural lands in need of replacement and/or rotating crops. Based on our findings, GST was identified as the optimal soil for planting A. orientale , providing a new resource for local farmers.

For the first time, the current work has carried out a chemical treatment of a novel ligno-cellulose fiber that is extracted from the bark of an unexplored plant of Careya arborea. Careya arborea (CA), a flowering tree known for its green berries, thrives in the Indian subcontinent and Afghanistan. This research was focused on extracting fibers from the bark of the Cary tree for the first time to corroborate the influence of chemical treatment on its different characteristics. These CA fibers have a high proportion of cellulose, consisting of 71.17 wt percent, together with 27.86 wt percent of hemicellulose, and a reduced density of 1140 kg/m 3 , making them a suitable candidate for creating lightweight applications in a variety of industries. Chemical treatment has done on the cay fiber with the concentrations of NaOH 5 (wt%), 10 (wt%), and 15 (wt%) solution mixture to improve their characteristics. Estimated the difference between Chemically processed and non-processed Cary fibers and corroborated in results. We performed a number of experiments, including FTIR, XRD, SEM, EDAX, AFM, and TGA, to fully comprehend the changing properties. Chemical testing showed that cellulose changed from its non-crystalline state to cellulose, proving that the treatment was successful in changing the fibre structure. Additionally, the thermo-gravimetric examination showed higher thermal stability 248 °C-325 °C and a rise in the crystallinity index, indicating the treated fibers' improved potential for high-temperature applications. The treated Cary fibers exhibited excellent surface properties, promising improved adhesion, mechanical performance, offering lightweight and sustainable solutions for diverse applications., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Gluteus medius, Longissimus thoracis, and Semitendinosus muscles from the cow and yak (Bos grunniens) reared in the Kyrgyz Republic were dried by convective (hot air) drying and freeze drying. The dried muscles were grinded into fine powders and along with raw muscles were evaluated for water activity (a W ), chemical composition (moisture, fat, protein), colour characteristics (L, a, and b values), fluorescence of intrinsic fluorophores (tryptophan, vitamin A, and riboflavin). Processing of measured data tables using common components and specific weights analysis (CCSWA) showed close relations among the chemical, colour, and fluorescence data. CCSWA discriminated muscles depending on chemical composition, animal type, and drying technique applied based on the chemical properties, colour characteristics, and fluorescence spectra. The freeze drying was approved as a preferable dehydration technique comparing with convective drying as the one causing less discoloration to meat. Partial Least Squares Regression (PLSR) models developed using fluorescence spectra allowed accurate quantitative predicting of water activity (a W ), moisture, fat, and protein contents, and colour characteristics (L, a, and b values)., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

The Sub-Saharan region of southern Africa is characterized by high temperatures, low rainfall, and poor land-use management practices such as continuous cropping without replenishment of soil nutrients. The combination of these factors has resulted in nutrient depletion and land degradation. The current study aimed at investigating the effect of arbuscular mycorrhizal fungi (AMF) and Rhizobium bacteria inoculation on soil chemical properties in field-grown forage legumes, namely, Mucuna pruriens (mucuna) , Lablab purpureus (lablab) and Vigna unguiculata (cowpea), in the semi-arid region of the Eastern Cape Province (South Africa). Forage legumes were inoculated with the AMF species Paraglomus occulum and the Rhizobia bacteria species Bradyrhizobium strain and grown for 120 days. Soil samples were collected in the following sequence: prior to planting, before flowering and after harvesting the forage legumes in each of the two seasons (2017/2018 and 2018/2019) and soil chemical properties were determined using standard procedures. The results showed that the addition of dual inoculation over time greatly improved soil chemical properties when compared to the control treatment. This was advocated by the significant ( P  ≤ 0.05) increase in soil pH, soil organic carbon, soil organic matter, total nitrogen, phosphorus, calcium, potassium, magnesium, sodium, sulfur and iron in soils. The concentration of cation exchange capacity was significantly ( P  ≤ 0.05) higher in cowpea treated with Rhizobium as compared to other treatment combinations. The control treatment of mucuna forage greatly improved the concentrations of manganese, boron, copper, molybdenum, and zinc over other treatment combinations only before the flowering stage. However, the concentrations of micronutrients were significantly higher on the treatment combination of lablab and single inoculation of AMF after harvesting. Generally, dual inoculation with AMF and Rhizobia enhanced soil properties when compared to a single inoculation or untreated control., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

The liver is the most important organ for biological transformation in the body and is crucial for maintaining the body's vital activities. Liver injury is a serious pathological condition that is commonly found in many liver diseases. It has a high incidence rate, is difficult to cure, and is prone to recurrence. Liver injury can cause serious harm to the body, ranging from mild to severe fatty liver disease. If the condition continues to worsen, it can lead to liver fibrosis and cirrhosis, ultimately resulting in liver failure or liver cancer, which can seriously endanger human life and health. Therefore, establishing an rodent model that mimics the pathogenesis and severity of clinical liver injury is of great significance for better understanding the pathogenesis of liver injury patients and developing more effective clinical treatment methods. The author of this article summarizes common chemical liver injury models, immune liver injury models, alcoholic liver injury models, drug-induced liver injury models, and systematically elaborates on the modeling methods, mechanisms of action, pathways of action, and advantages or disadvantages of each type of model. The aim of this study is to establish reliable rodent models for researchers to use in exploring anti-liver injury and hepatoprotective drugs. By creating more accurate theoretical frameworks, we hope to provide new insights into the treatment of clinical liver injury diseases., Competing Interests: Declaration of competing interest All authors declare that there have no any commercial or associative interest that represents competing interests in connection with the work submitted., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)

Long-term application of organic and mineral fertilizers can lead to changes in the elemental composition of agroecosystem components. Both the levels of nutrients and potentially toxic elements can change, as can the potential for these elements to be available to plants through changes in soil properties. Soil and plant samples of two species (pea Pisum sativum L. and oat Avena sativa L.) were collected from plots of a long-term field experiment on the application of mineral and organic fertilizers and their combinations to gray forest soils in the Vladimir region, Russia. Soil samples from the 0-20 and 20-40 cm layers were subjected to acid digestion to determine total element content. Mobile forms of elements were extracted from topsoil samples using acetate-ammonium buffer (pH 4.8). Sample preparation of pea and oat plant organs (stems, leaves, pods/ears) included sample digestion in a microwave sample digestion system ETHOS EASY (Milestone, Italy). The elemental composition of the samples was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) using Agilent 5800 ICP-OES (Agilent Technologies, USA). The dataset includes concentration data for 34 elements, including rare earth elements, in these samples collected in 2021. The dataset also contains general agrochemical characteristics of soils of the experimental groups: pH of water and salt suspension, organic carbon content, mobile forms of phosphorus. The data can be valuable to researchers developing fertilizer application systems and modeling changes in the elemental composition of agroecosystems., (© 2024 The Author(s).)

Over the past eight years, bee products such as wax, honey, propolis, and pollen have generated intense curiosity about their potential food uses; to explore these possibilities, this review examines the nutritional benefits and notable characteristics of each product related to the food industry. While all offer distinct advantages, there are challenges to overcome, including the risk of honey contamination. Indeed, honey has excellent potential as a healthier alternative to sugar, while propolis's remarkable antibacterial and antioxidant properties can be enhanced through microencapsulation. Pollen is a versatile food with multiple applications in various products. In addition, the addition of beeswax to oleogels and its use as a coating demonstrate significant improvements in the quality and preservation of environmentally sustainable foods over time. This study demonstrates that bee products and apitherapy are essential for sustainable future food and innovative medical treatments., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Machine Learning (ML) is increasingly applied to fill data gaps in assessments to quantify impacts associated with chemical emissions and chemicals in products. However, the systematic application of ML-based approaches to fill chemical data gaps is still limited, and their potential for addressing a wide range of chemicals is unknown. We prioritized chemical-related parameters for chemical toxicity characterization to inform ML model development based on two criteria: (1) each parameter's relevance to robustly characterize chemical toxicity described by the uncertainty in characterization results attributable to each parameter and (2) the potential for ML-based approaches to predict parameter values for a wide range of chemicals described by the availability of chemicals with measured parameter data. We prioritized 13 out of 38 parameters for developing ML-based approaches, while flagging another nine with critical data gaps. For all prioritized parameters, we performed a chemical space analysis to assess further the potential for ML-based approaches to predict data for diverse chemicals considering the structural diversity of available measured data, showing that ML-based approaches can potentially predict 8-46% of marketed chemicals based on 1-10% with available measured data. Our results can systematically inform future ML model development efforts to address data gaps in chemical toxicity characterization.

The new actual scientific direction is in the development of different nanocomposites and the study of their medical-biological, physicochemical, and physicomechanical properties. One way to expand the functionality of nanocomposites and nanomaterials is to introduce carbon nanostructures into the polymer matrix. This study presents the properties of unsaturated polyester resins (Estromal, LERG S.A.) based on PET recyclate with multi-walled carbon nanotubes (MWCNTs): their mechanical and thermomechanical characteristics, resistance to ultraviolet radiation (UV-vis), and chemical resistance properties. The properties of the obtained materials were characterized using physical-chemical research methods. The changes in the properties of the composites for MWCNT content of 0.1, 0.3, and 0.5 wt % were determined. The results showed positive influences on the thermomechanical and mechanical properties of nanocomposites without significant deterioration of their gloss. Too much CNT added to the resin leads to heterogeneity of the composite structure.

Bamboo forests, which have come to occupy large areas in recent years, naturally undergo the process of blooming. However, bamboo culms and rhizomes degenerate after the plants bloom, resulting in widespread loss of raw materials. Systematic research on the properties and physiology of bamboo culms after flowering is lacking, and whether flowering bamboo culms could be used as raw materials in industry is unclear. In this paper, we compared and measured the fiber morphology, chemical components, and sugar metabolism indexes of non-flowering and flowering Bambusa tuldoides culms at different ages. The results showed that the fibers in the middle internodes of both non-flowering and flowering B. tuldoides culms had the longest length. The fibers completed their elongation within 1 year, but the fiber walls were continually deposited with age. The levels of the chemical components in the nonflowering culms also continually increased with age. The nonstructural carbohydrate (NSC) content and sugar metabolism indexes showed the highest levels in the 2-year culms and then declined in the 3-year culms. Compared to young culms that had not yet flowered, the 3-month-old and 1-year-old flowering culms had a significant decrease in the fiber length and tangential diameter, and their holocellulose and lignin levels also decreased, while the levels of ash, SiO 2 , 1% NaOH extractives, and benzene-ethanol extractives increased. A correlation analysis showed that sugar catabolism was accelerated in the flowering cluster, which could lead to "starvation death" in bamboo and which had a significant negative impact on the anatomical and chemical properties of the bamboo culms. Generally, the flowering bamboo culms had shorter fibers, higher levels of extractives and ash, and lower holocellulose content, which indicated that bamboo flowering has an adverse effect on the application of such components in the production of pulp, in papermaking, and in other processing and utilization activities. This study revealed the physiological changes in flowering B. tuldoides culms and provided a theoretical basis to inform the utilization of culms in this species., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Liu, Wu, Zhou, Zhang, Wang, Liu, Yang and Wang.)

To complement previous results, an analysis of the chemical and morphological properties of babassu fibers ( Attalea speciosa Mart. ex Spreng .) was conducted in order to evaluate their potential as reinforcements in the production of composites with epoxy matrix. The diameter distribution was analyzed in a sample of one hundred fibers, allowing the verification of its variation. The determination of the chemical properties involved experimental analyses of the constituent index and X-ray diffraction. The diffractogram was used to calculate the crystallinity index and the microfibril angle, which are crucial parameters that indicate the consistency of the mechanical properties of babassu fibers and the feasibility of their use in composites. The results revealed that babassu fiber has a chemical composition, with contents of 28.53% lignin, 32.34% hemicellulose, and 37.97% cellulose. In addition, it showed a high crystallinity index of 81.06% and a microfibril angle of 7.67°. These characteristics, together with previous results, indicate that babassu fibers have favorable chemical and morphological properties to be used as reinforcements in composites, highlighting its potential as an important material for applications in technology areas.

Poly(amide-imide) (PAI), serving as a synthetic polymer, has been widely used in industry for excellent mechanical properties, chemical resistance and high thermal stability. However, lack of suitable cell niche and biological activity limited the further application of PAI in biomedical engineering. Herein, silicon modified L-phenylalanine derived poly(amide-imide) (PAIS) was synthesized by introducing silica to L-phenylalanine derived PAI to improve physicochemical and biological performances. The influence of silicon amount on physicochemical, immune, and angiogenic performances of PAIS were systemically studied. The results show that PAIS exerts excellent hydrophilic, mechanical, biological activity. PAIS shows no effects on the number of macrophages, but can regulate macrophage polarization and angiogenesis in a dose-dependent manner. This study advanced our understanding of silicon modification in PAI can modulate cell responses via initiating silicon concentration regulation. The acquired knowledge will provide a new strategy to design and optimize biomedical PAI in the future., (© 2023 Wiley Periodicals LLC.)

Garlic, a common culinary spice, is cultivated and used around the globe. Consumption of garlic and its supplements reduces the risk of diabetes and cardiovascular disease and boosts the immune system with antibacterial, antifungal, anti-aging, and anti-cancer properties. Diallyl sulfide, diallyl disulfide, triallyl trisulfide, phenolics, flavonoids, and others are the most commercially recognized active ingredients in garlic and its products. In recent years, global demand for medicinal or functional garlic has surged, introducing several products such as garlic oil, aged garlic, black garlic, and inulin into the market. Garlic processing has been demonstrated to directly impact the availability of bioactive ingredients and the functionality of products. Depending on the anticipated functional qualities, it is also recommended that one or a combination of processing techniques be deemed desirable over the others. This work describes the steps involved in processing fresh garlic into products and their physicochemical alterations during processing. Their nutritional, phytochemical, and functional properties are also reviewed. Considering the high demand for functional food, this review has been compiled to provide guidance for food producers on the industrial utilization and suitability of garlic for new product development., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Sunanta, Kontogiorgos, Pankasemsuk, Jantanasakulwong, Rachtanapun, Seesuriyachan and Sommano.)

In this work, poly (vinyl alcohol) (PVA) was employed to produce a Mesoporous Composition of Matter-48 Modified (MCM-48-M or MCM-48-PVA). After surface modification, MCM-48-M was used to produce nanocomposite (NC) films with polycaprolactone (PCL) as a matrix at room temperature. PCL and MCM-48 nanoparticles (NPs) were chosen due to their great biocompatibility and low toxicity. However, MCM-48-M is more compatible with PCL than MCM-48. NC films were sterilized by gamma radiation with a dose of 25 kGy and characterized by experimental techniques to investigate their chemical, mechanical (tensile) and thermal properties. Scanning electron microscopy (SEM) and transmission electronic microscopy (TEM) results indicated that MCM-48-M exhibited a random distribution in the PCL matrix. The PCL chemical structure was preserved in NC films as described by Fourier transform infrared (FT-IR) spectroscopy as well as the tensile and thermal properties of NC films. FT-IR and thermogravimetric analysis (TGA) results showed surface modification. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) showed that crystalline symmetries were preserved and the crystallinity of NC films had small variations in all samples before and after irradiation, respectively. But, our results did not indicate major changes showing that this method is successful for the sterilization of PCL/MCM-48-PVA NC films., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)

Biochar is important for soil improvement, fertilizer innovation, and greenhouse gas reduction. In this paper, Mg-modified biochar was prepared from rice and corn straw and mixed with soil at a 1% ( w / w ) addition in an indoor soil simulation experiment to study the effect of Mg-modified biochar on the chemical properties of acidic soil. The results showed that the addition of Mg-modified biochar reduced soil acidity and improved soil fertility. Compared with the control group, the Mg-modified biochar treatment significantly increased the concentrations of available potassium, available phosphorus, total phosphorus, organic carbon and exchangeable calcium and magnesium in the soil, and effectively increased the concentration of total nitrogen. Rice straw Mg-modified biochar treatment was more effective in increasing the soil-available potassium, available phosphorus, total phosphorus and exchangeable magnesium concentration, while corn straw Mg-modified biochar was more effective in increasing the soil organic carbon and exchangeable calcium concentration. In addition, the high pyrolysis temperature of Mg-modified biochar was more effective in promoting the soil-available potassium, available phosphorus and total nitrogen concentration, while the low pyrolysis temperature of Mg-modified biochar was more effective in promoting soil alkaline nitrogen, exchangeable calcium and magnesium.

Increased attention has been given to whole grain and plant-based foods due to health concerns. Sweet fermented oats (SFOs) are such traditional fermented food from China. However, reports on their microbiota and relations with the nutrients and flavor were scarcely few, hindering their wider application. The comprehensive microbial composition, metabolic compounds and their correlations of representative SFOs from northwestern China were firstly investigated. Firmicutes predominated the microbial communities, followed by Proteobacteria. Weissella, Bacillus and Lactobacillus were dominant bacterial genera, biomarkers and core bacteria as well. GC-MS (Gas Chromatography-Mass Spectrometer) identified the metabolic compounds, among which the categories fatty acids and carboxylic acids most abundant. Eighteen chemicals showed significant differences among the five SFOs, including ethyl octanoate, neryl acetate, L-sorbose, diglycerol, cellotetraose etc. Fatty acids, carboxylic acids, amino acids, peptides, oligosaccharides, and monosaccharides were the key substances responsible for the unique flavor and rich nutrients in SFOs. The core bacteria were closely related to chemical acids, esters, flavone and alcohol. Pediococcus showed a negative correlation with 2,3-butanediol. SFOs were made in the laboratory with the core bacterial strains, obtaining a high abundance of nutrient chemicals and sensory evaluation value. The research provided a foundation for the improvement, further application and industrialization of SFOs., (© 2023. The Author(s), under exclusive licence to Springer Nature B.V.)

Background: Tricalcium silicate is the main component of commercial bioceramic cements that are widely used in endodontic treatment. Calcium carbonate, which is manufactured from limestone, is one of the substrates of tricalcium silicate. To avoid the environmental impact of mining, calcium carbonate can be obtained from biological sources, such as shelled mollusks, one of which is cockle shell. The aim of this study was to evaluate and compare the chemical, physical, and biological properties of a newly developed bioceramic cement derived from cockle shell (BioCement) with those of a commercial tricalcium silicate cement (Biodentine)., Methods: BioCement was prepared from cockle shells and rice husk ash and its chemical composition was determined by X-ray diffraction and X-ray fluorescence spectroscopy. The physical properties were evaluated following the International Organization for Standardization (ISO) 9917-1;2007 and 6876;2012. The pH was tested after 3 h to 8 weeks. The biological properties were assessed using extraction medium from BioCement and Biodentine on human dental pulp cells (hDPCs) in vitro. The 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5[(phenylamino)carbonyl]-2 H-tetrazolium hydroxide assay was used to evaluate cell cytotoxicity following ISO 10993-5;2009. Cell migration was examined using a wound healing assay. Alizarin red staining was performed to detect osteogenic differentiation. The data were tested for a normal distribution. Once confirmed, the physical properties and pH data were analyzed using the independent t-test, and the biological property data were analyzed using one way ANOVA and Tukey's multiple comparisons test at a 5% significance level., Results: The main components of BioCement and Biodentine were calcium and silicon. BioCement's and Biodentine's setting time and compressive strength were not different. The radiopacity of BioCement and Biodentine was 5.00 and 3.92 mmAl, respectively (p < 0.05). BioCement's solubility was significantly higher than Biodentine. Both materials exhibited alkalinity (pH ranged from 9 to 12) and demonstrated > 90% cell viability with cell proliferation. The highest mineralization was found in the BioCement group at 7 days (p < 0.05)., Conclusions: BioCement exhibited acceptable chemical and physical properties and was biocompatible to human dental pulp cells. BioCement promotes pulp cell migration and osteogenic differentiation., (© 2023. The Author(s).)

The freeze-thaw (F/T) method is commonly employed during the processing and handling of drug substances to enhance their chemical and physical stability and obtain pharmaceutical applications such as hydrogels, emulsions, and nanosystems (e.g., supramolecular complexes of cyclodextrins and liposomes). Using F/T in manufacturing hydrogels successfully prevents the need for toxic cross-linking agents; moreover, their use promotes a concentrated product and better stability in emulsions. However, the use of F/T in these applications is limited by their characteristics (e.g., porosity, flexibility, swelling capacity, drug loading, and drug release capacity), which depend on the optimization of process conditions and the kind and ratio of polymers, temperature, time, and the number of cycles that involve high physical stress that could change properties associated to quality attributes. Therefore, is necessary the optimization of F/T conditions and variables. The current research regarding F/T is focused on enhancing the formulations, the process, and the use of this method in pharmaceutical, clinical, and biological areas. The present review aims to discuss different studies related to the impact and effects of the F/T process on the physical, mechanical, and chemical properties (porosity, swelling capacity) of diverse pharmaceutical applications with an emphasis on their formulation properties, the method and variables used, as well as challenges and opportunities in developing. Finally, we review the experimental approach for choosing the standard variables studied in the F/T method applying the systematic methodology of quality by design., (© 2023. The Author(s).)

We evaluated the microbial composition of water kefir grains and beverage over the course of one year to determine whether the number and type of microorganisms changed over the time. Bacteria and yeast colonies with different morphologies were isolated from water kefir and their antimicrobial activity was evaluated against Paenibacillus larvae and Ascosphaera apis. A chemical characterization of kefir was also carried out. Our results confirmed that bacteria and yeasts were more numerous in kefir grains compared with those in the beverage. The counts of microorganisms declined, although an important microbial community was still present in kefir after the long storage period. Eleven strains which inhibited bee pathogens were isolated from kefir. Genotypic results demonstrated that these isolates included Lentilactobacillus hilgardii, Lentilactobacillus buchneri and Saccharomyces cerevisiae. Thus, water kefir may be an innovative source of potential probiotic strains for bee nutrition in order to control honeybee diseases., (Copyright © 2022 Asociación Argentina de Microbiología. Publicado por Elsevier España, S.L.U. All rights reserved.)

Drying is one of the oldest methods of obtaining a product with a long shelf-life. Recently, this process has been modified and accelerated by the application of pulsed electric field (PEF); however, PEF pretreatment has an effect on different properties-physical as well as chemical. Thus, the aim of this study was to investigate the effect of pulsed electric field pretreatment and air temperature on the course of hot air drying and selected chemical properties of the apple tissue of Gloster variety apples. The dried apple tissue samples were obtained using a combination of PEF pretreatment with electric field intensity levels of 1, 3.5, and 6 kJ/kg and subsequent hot air drying at 60, 70, and 80 °C. It was found that a higher pulsed electric field intensity facilitated the removal of water from the apple tissue while reducing the drying time. The study results showed that PEF pretreatment influenced the degradation of bioactive compounds such as polyphenols, flavonoids, and ascorbic acid. The degradation of vitamin C was higher with an increase in PEF pretreatment intensity level. PEF pretreatment did not influence the total sugar and sorbitol contents of the dried apple tissue as well as the FTIR spectra. According to the optimization process and statistical profiles of approximated values, the optimal parameters to achieve high-quality dried apple tissue in a short drying time are PEF pretreatment application with an intensity of 3.5 kJ/kg and hot air drying at a temperature of 70 °C.

Burning wood is estimated to produce about 6-10% of ash. Despite the possibility of recycling wood ash (WA), approximately 70% of the wood ash generated is landfilled, causing costs as well as environmental pollution. This study aims to recycle WA in an alternative way by inserting it as filler in geopolymeric materials. Here, metakaolin, NaOH, sodium silicate, and WA are used to realize geopolymers. Geopolymers without and with 10, 20 and 30% of WA are synthesized and characterized after 7, 14, 28 and 56 days. The article's study methods are related to geopolymers' chemical, biological and mechanical properties. The geopolymers synthesized are compact and solid. The pH and conductivity tests and the integrity and weight loss tests have demonstrated the stability of materials. The FT-IR study and boiling water test have confirmed the successful geopolymerization in all samples. The antibacterial analysis, the moss growing test and the compressive strength test have given a first idea about the durability of the materials synthesized. Furthermore, the compressive strength test result has allowed the comparison from the literature of the specimens obtained with the Portland cement (PC). The results obtained bode well for the future of this material.

The chemical analysis of vineyards is an essential tool for the early detection of risks, such as excessive fertilization and heavy metal and pesticide contamination in farm management. Soil and plant samples were collected in summer and winter from six different vineyards with varying agricultural practices in the Cape Winelands of the Western Cape Province, South Africa. The samples were pretreated in a microwave using CEM MARS 6™ Microwave Digestion and Extraction System (CEM Corporation, Matthews, NC, USA). Chemical element data were obtained using an inductively coupled plasma optical emission spectrometer (ICP-OES) (ICP Expert II, Agilent Technologies 720 ICP-OES). The data will be valuable for selecting and improving farming practices and gaining insights into the influence of seasonal variation and agricultural practices on the elemental accumulation in farmlands., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Author(s).)

Idesia polycarpa pulp oil (IPPO) has the potential to become the new high-quality vegetable oil. The chemical parameters, fatty acid composition, bioactive ingredients, and antioxidant capacity of five Chinese regions of IPPO were studied comparatively, with significant differences among the regions. The oils were all abundant in unsaturated fatty acids, including linoleic acid (63.07 ± 0.03%-70.69 ± 0.02%), oleic acid (5.20 ± 0.01%-7.49 ± 0.03%), palmitoleic acid (4.31 ± 0.01%-8.19 ± 0.01%) and linolenic acid (0.84 ± 0.03%-1.34 ± 0.01%). IPPO is also rich in active substances such as tocopherols (595.05 ± 11.81-1490.20 ± 20.84 mg/kg), which are made up of α, β, γ and δ isomers, β-sitosterol (1539.83 ± 52.41-2498.17 ± 26.05 mg/kg) and polyphenols (106.77 ± 0.86-266.50 ± 2.04 mg GAE/kg oil). The free radical scavenging capacity of IPPO varies significantly depending on the region. This study may provide important guidance for the selection of Idesia polycarpa and offer insights into the industrial application of IPPO in China.

Chemical and liquid chromatography-mass spectrometry (LC/MS)-based lipidomics analyses were performed to explore the alterations in lipid profiles in the hairtail muscle during air-drying. The peroxide value (POV) and carbonyl group value (CGV) in the air-dried hairtail (ADH) significantly increased with air-drying time. Lipidomics results revealed 1,326 lipids, which were grouped into 33 lipid categories, including 422 triglycerides (TGs), 170 phosphatidylcholines (PCs), 110 phosphatidylethanolamines (PEs), among others. In addition, ADH contained 131 and 201 differentially abundant lipids (DALs) at high and low levels, respectively. Among them, DALs, TGs, PCs, LPCs, and LPEs could be used to distinguish between ADH and FH samples. The apparent alterations in ADH and FH samples were attributed to lipid decomposition, side-chain modifications during oxidation, or oxygen- and salt-promoted lipid oxidation. Thus, this study provides a more comprehensive understanding of hairtail lipid profiles before and after air-drying which can be used as a guide for hairtail products., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2023 The Authors. Published by Elsevier Ltd.)

Continuous cropping of the same crop leads to soil degradation and a decline in crop production, and these impacts could be mitigated through rotation cropping. Although crop rotation enhances soil fertility, microbial community diversity, and potato yield, its effects on the soil ecosystem multifunctionality (EMF) remain unclear. In the present research, we comparatively examined the effects of potato continuous cropping (PP) and rotation cropping [potato-oat rotation (PO) and potato-forage maize rotation (PFM)] on the soil EMF as well as the roles of keystone taxa, microbes abundance, and chemical properties in EMF improvement. It was demonstrated that soil EMF is increased in rotation cropping (PO and PFM) than PP. Soil pH was higher in rotation cropping (PO and PFM) than in PP, while total phosphorus (TP) and available phosphorus (AP) were significantly decreased than that in PP. Rotation cropping (PO and PFM) markedly changed the bacterial and fungal community compositions, and improved the potential plant-beneficial fungi, e.g., Schizothecium and Chaetomium , while reducing the abundances of the potentially phytopathogenic fungi, e.g., Alternaria , Fusarium , Verticillium dahiae , Gibberella , Plectosphaerella , Colletotrichum , Phoma , and Lectera in comparison with PP. Also, co-occurrence patterns for bacteria and fungi were impacted by crop rotation, and keystone taxa, e.g., Nitrospira .1, Lysinibacillus , Microlunatus .1, Sphingomonas .3, Bryobacter .1, Micromonospora , and Schizothecium , were enriched in PO and PFM than PP. The structural equation model (SEM) further demonstrated that cropping systems increased soil ecosystem multifunctionality through regulating SOM and keystone taxa ( Schizothecium 1), and keystone taxa were mediated by soil pH. This study suggested that rotation cropping might contribute to the improvement of soil ecosystem multifunctionality as well as the development of disease-suppressive soils in comparison with potato continuous cropping., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Li, Zhang, Zhang, Zhou, Pan, Yang, Zhu, Liu and Zhang.)

The root rot disease causes a great economic loss, and the disease severity usually increases as ginseng ages. However, it is still unclear whether the disease severity is related to changes in microorganisms during the entire growing stage of American ginseng. The present study examined the microbial community in the rhizosphere and the chemical properties of the soil in 1-4-year-old ginseng plants grown in different seasons at two different sites. Additionally, the study investigated ginseng plants' root rot disease index (DI). The results showed that the DI of ginseng increased 2.2 times in one sampling site and 4.7 times in another during the 4 years. With respect to the microbial community, the bacterial diversity increased with the seasons in the first, third, and fourth years but remained steady in the second year. The seasonal changing of relative abundances of bacteria and fungi showed the same trend in the first, third, and fourth years but not in the second year. Linear models revealed that the relative abundances of Blastococcus, Symbiobacterium, Goffeauzyma, Entoloma, Staphylotrichum, Gymnomyces, Hirsutella, Penicillium and Suillus spp. were negatively correlated with DI, while the relative abundance of Pandoraea, Rhizomicrobium, Hebeloma, Elaphomyces, Pseudeurotium, Fusarium, Geomyces, Polyscytalum, Remersonia, Rhizopus, Acremonium, Paraphaeosphaeria, Mortierella, and Metarhizium spp. were positively correlated with DI ( P < 0.05). The Mantel test showed that soil chemical properties, including available nitrogen, phosphorus, potassium, calcium, magnesium, organic matter, and pH, were significantly correlated to microbial composition. The contents of available potassium and nitrogen were positively correlated with DI, while pH and organic matter were negatively correlated with DI. In summary, we can deduce that the second year is the key period for the shift of the American ginseng rhizosphere microbial community. Disease aggravation after the third year is related to the deterioration of the rhizosphere microecosystem., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Bi, Zhang, Jiao, Li, Peng, Tian, Wang and Gao.)

(1) Background: Starch is the main component of mango ( Mangifera indica ) kernel, making it an alternative to obtain an ingredient from a non-conventional source with potential application in food and other industrial applications; however, reports on the use of new extraction techniques for this material are scarce. The main objective of this research was to evaluate the effect of ultrasound-assisted extraction (UAE) on the yield, chemical, techno-functional, rheological, and pasting properties of starch isolated from a non-conventional source such as a mango kernel. (2) Methods: Different power sonication conditions (120, 300, and 480 W) and sonication time (10, 20, and 30 min) were evaluated along with a control treatment (extracted by the wet milling method). (3) Results: Ultrasound-assisted extraction increases starch yield, with the highest values (54%) at 480 W and 20 min. A significant increase in the amylose content, water-holding capacity, oil-holding capacity, solubility, and swelling power of ultrasonically extracted starches was observed. Similarly, mango kernel starch (MKS) exhibited interesting antioxidant properties. The sol-gel transition temperature and pasting parameters, such as the breakdown viscosity (BD) and the setback viscosity (SB), decreased with ultrasound application; (4) Conclusion: indicating that ultrasound caused changes in physical, chemical, techno-functional, rheological, and pasting properties, depending on the power and time of sonication, so it can be used as an alternative starch extraction and modification technique, for example, for potential application in thermally processed food products such as baked goods, canned foods, and frozen foods.

High entropy alloys (HEAs) of the type CrCuFeNiTi-Alx were processed through mechanical alloying. The aluminum concentration was varied in the alloy, to determine its effect on the HEAs' microstructure, phase formation, and chemical behavior. X-ray diffraction studies performed on the pressureless sintered samples revealed the presence of structures composed of face centered cubic (FCC) and body centered cubic (BCC) solid-solution phases. Since the valences of the elements that form the alloy are different, a nearly stoichiometric compound was obtained, increasing the final entropy of the alloy. The aluminum was partly responsible for this situation, which also favored transforming part of the FCC phase into BCC phase on the sintered bodies. X-ray diffraction also indicated the formation of different compounds with the alloy's metals. Bulk samples exhibited microstructures with different phases. The presence of these phases and the results of the chemical analyses revealed the formation of alloying elements that, in turn, formed a solid solution and, consequently, had a high entropy. From the corrosion tests, it could be concluded that the samples with a lower aluminum content were the most resistant to corrosion.

Soils of Mediterranean forests can be severely degraded due to wildfire. However, post-fire management techniques, such as soil mulching with vegetal residues, can limit degradation and increase functionality of burned soils. The effects of post-fire mulching on soil functionality have been little studied in Mediterranean forests, and it is still unclear whether the application of straw or wood residues is beneficial. This study explores the changes in important soil chemical and biochemical properties in a pine forest of Central Eastern Spain after a wildfire and post-fire mulching with straw or wood chips. Only basal soil respiration (BSR), dehydrogenase activity (DHA), pH and water field capacity (WFC) significantly changed after the fire and mulching. In contrast, the other enzymatic activities - urease (UA), alkaline phosphatase (Alk-PA) and β-glucosidase (BGA), - total organic carbon (TOC) and electrical conductivity (EC) were not influenced by these soil disturbances. Time from fire and soil conditions (due to burning and management) were significant variability factors for BSR, pH, BGA, UA, TOC, EC. Mulching increased BSR compared to burned areas, especially in soils with straw (+30 %), thanks to addition of fresh organic residues, quickly incorporated in the soil. Soil pH showed a low variability among the four soil conditions, and TOC was higher in mulched soils (on average + 20 % compared to the burned soils), and this was correlated to the increased BSR. The role of mulching was essential with reference to WFC, as the post-fire management limited its reduction after the fire (on average from -30 % to -20 %). Finally, the Principal Component Analysis coupled to the Analytical Hierarchical Cluster Analysis confirmed the significant influence of the post-fire management on some enzymatic activities, although a sharp discrimination among the four soil conditions was only evident between unburned and burned sites, regardless of the management. Overall, it has been shown that mulching promotes conservation of fragile Mediterranean soils, indicating its effectiveness at preserving soil functionality in areas affected by forest fires., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier B.V.)

Objectives: To investigate the water sorption (w sp ), water solubility (w sl ), degree of conversion (DC), elastic indentation modulus (E IT ), edge chipping resistance (ECR) and flexural strength (FS) of 3D-printed, milled and conventionally polymerized denture base resin materials., Methods: Specimens (N = 540) were 3D-printed (NextDent Denture 3D+ (DEN), Fotodent Denture (FOT), Freeprint Denture (FRE), V-Print dentbase (VPR)), cut (Ivotion Base (IVO)) and molded (PalaXpress (PAL)) in three geometries. W sp, w sl, DC, E IT , ECR and FS were tested initially (24 h, 37 °C, H20) and after additional aging (5000 thermal cycles, 5/55 °C). Data were analyzed with Kolmogorov-Smirnov, univariate ANOVA, Kruskal-Wallis, Mann-Whitney U test and Spearman's correlation (p < 0.05) RESULTS: Most 3D-printed denture base resins showed higher w sp (25.31-37.94 μg/mm 3 ) and w sl (0.08-8.27 μg/mm 3 ), but also higher E IT (3.11-4.09 GPa) and FS (60.81-99.57N/mm 2 ) values than the control groups. DEN and VPR showed high DC (89.36-93.53%), E IT (3.77-4.09 GPa) and FS (79.65-99.57N/mm 2 ), while FOT showed low w sp (25.31-27.35 μg/mm 3 ) and w sl (1.01-3.87 μg/mm 3 ) values. In all materials, the examined parameters were affected by aging., Significance: Although 3D-printed denture base resins showed promising results with regard to the observed DC and FS, only FOT and FRE surpassed the threshold values defined by the ISO norms., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Malignant tumors are the second leading cause of death worldwide. This is a public health concern that negatively impacts human health and poses a threat to the safety of life. Although there are several treatment approaches for malignant tumors, surgical resection remains the primary and direct treatment for malignant solid tumors. Anesthesia is an integral part of the operation process. Different anesthesia techniques and drugs have different effects on the operation and the postoperative prognosis. Propofol is an intravenous anesthetic that is commonly used in surgery. A substantial number of studies have shown that propofol participates in the pathophysiological process related to malignant tumors and affects the occurrence and development of malignant tumors, including anti-tumor effect, pro-tumor effect, and regulation of drug resistance. Propofol can also reshape the tumor microenvironment, including anti-angiogenesis, regulation of immunity, reduction of inflammation and remodeling of the extracellular matrix. Furthermore, most clinical studies have also indicated that propofol may contribute to a better postoperative outcome in some malignant tumor surgeries. Therefore, the author reviewed the chemical properties, pharmacokinetics, clinical application and limitations, mechanism of influencing the biological characteristics of malignant tumors and reshaping the tumor microenvironment, studies of propofol in animal tumor models and its relationship with postoperative prognosis of propofol in combination with the relevant literature in recent years, to lay a foundation for further study on the correlation between propofol and malignant tumor and provide theoretical guidance for the selection of anesthetics in malignant tumor surgery., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Zhou, Shao, Li, Zhang, Ding, Zhuang and Sun.)

Background: Quality control of Traditional Chinese Medicines (TCMs) has improved greatly, but there is still a lack of a convincing quality evaluation system for TCMs. Developing quality control markers of TCMs based on pharmacodynamics instead of content has been an attractive approach. However, on account of neglecting phytochemistry attributes of TCMs, part of effective markers might be short of specificity and inconvenient for detecting in production manufacture, which is adverse to control the quality of TCMs systematically., Purpose: To build a novel and multidimensional quality assessment approach for TCMs based on pharmacodynamics and chemical properties., Methods: Schisandra chinensis (Turcz.) Baill (S. chinensis) was used as an example and a rat depression model was built by using a chronic unpredictable mild stress procedure. For identifying the antidepressive components of S. chinensis, we elucidated its antidepressant mechanism in first-step by using quantitative RT-PCR and immunoblotting techniques. And accordingly, correlation analysis between ingredients in vivo with target proteins and anti-inflammation experiments in vitro were carried out. On the other hand, HPLC fingerprint combinations with diverse chemometrics methods were applied to analyze 14 preparations of S. chinensis to obtain its characteristic chemical information. Finally, we ascertained the quality control markers of S. chinensis by integrating the efficacious and characteristic constituents., Results: Our research indicated that S. chinensis treated depression by relieving disordered monoaminergic system and ameliorating neuroinflammation. Five effective substances (schisandrol A, schisandrin A, gomisin N, schisandrin B, and schisandrin C) were screened out according to their potential anti-depression efficacy. Besides, 21 common ingredients and 4 representative constituents of S. chinensis were identified by chemical analysis, whereas only 2 characteristic quantitative markers (schisandrol A, schisandrol B) were ultimately ascertained based on previous studies., Conclusion: 6 components, schisandrol A, schisandrin A, gomisin N, schisandrin B, schisandrin C, and schisandrol B, possessed efficacy, measurability, and specificity, were selected as the comprehensive markers for quality control of S. chinensis. We proposed a multidimensional strategy for identifying comprehensive quality markers for TCMs in this study., Competing Interests: Declaration of Competing Interest We declare that there are no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022. Published by Elsevier GmbH.)

Over the past several decades, the value of drinking water treatment residuals (WTRs), a byproduct of the coagulation process during water purification, has been recognized in various environmental applications, including sustainable remediation of phosphorus (P)-enriched soils. Aluminum-based WTRs (Al-WTRs) are suitable adsorbent materials for P, which can be obtained and processed inexpensively. However, given their heterogeneous nature, it is essential to identify an easily analyzable chemical property that can predict the capability of Al-WTRs to bind P before soil amendment. To address this issue, thirteen Al-WTRs were collected from various geographical locations around the United States. The non-hazardous nature of the Al-WTRs was ascertained first. Then, their P adsorption capacities were determined, and the chemical properties likely to influence their adsorption capacities were examined. Statistical models were built to identify a single property to best predict the P adsorption capacity of the Al-WTRs. Results show that all investigated Al-WTRs are safe for environmental applications, and oxalate-extractable aluminum is a significant indicator of the P adsorption capacity of Al-WTRs ( p -value = 0.0002, R 2 = 0.7). This study is the first to report a simple chemical test that can be easily applied to predict the efficacy of Al-WTRs in binding P before their broadscale land application.

(1) Background : Hemp seeds are a source of plant-based protein, making them an appropriate supplement to a plant-based diet. The current work was focused on the preparation of the protein isolate from the hemp seeds with eco-friendly and cheap technology. Moreover, it evaluated the physicochemical and functional properties of hemp protein isolate for its potential application in food manufacturing. (2) Methods: The protein content of hemp seeds has been isolated through two main steps: (1) extraction of the protein content of an alkaline pH (10-12); (2) precipitation of the extracted protein on an acidic pH as an isoelectric point (pH = 4.5). (3) Results: The edastin protein is the most predominant protein in the protein profile with a molecular weight of 58.1 KDa beside albumin with a molecular weight of 31.5 KDa. The FTIR spectrum detected the absorption peaks of the amide I at 1750 and 1600 cm -1 , which pointed to C=O stretching while N-H stretching at 1650-1580 cm -1 . The peak at 3250 is found to be related to N-H stretching of the aliphatic primary amine (3400-3300 cm -1 ) and the N-H stretching for the secondary (II) amine appeared at 3350-3310 cm -1 . The Hemp protein isolate (HPI) showed a high content of arginine (15.52 g/100 g), phenylalanine + tyrosine (9.63 g/100 g), methionine + cysteine (5.49 g/100 g), leucine + isoleucine (5.21 g/100 g), and valine (4.53 g/100 g). It contains a moderate level of threonine (3.29 g/100 g) and lysine (2.50 g/100 g) with tryptophan as the limiting amino acid (0.22 g/100 g). The HPI showed an appropriate water-and-oil holding capacity (4.5 ± 2.95 and 2.33 ± 1.88 mL/g, respectively). The foaming capacity of the HPI was increased with increasing the pH values to reach the maximum value at pH 11 (67.23 ± 3.20%). The highest emulsion ability index of the HPI was noted at pH 9 (91.3 ± 2.57 m 2 /g) with low stability (19.15 ± 2.03). (4) Conclusions: A strong positive correlation (r = 0.623) was shown between protein concentration and solubility. The current easy-to-use, cheap, and eco-friendly technology provides the industrial sector with a cheap protein isolate for manufacturing protein-rich diet and beverages. The HPI showed a good nutritional quality and functional properties that might be helpful in utilizing it in different food products such as beverages and bakery products.

Background: Sequential chemical application for irrigating a root canal during chemomechanical debridement can affect the dentin microstructure. Understanding the effects of various irrigants on chemical properties of dentin can elucidate their effects on physical properties and thereby explain the higher incidence of structural failure in endodontically treated teeth. This in vitro research aimed to compare and evaluate the effects of three different irrigating solutions on the chemical structure of root canal dentin in extracted human teeth. Methods: Forty-eight extracted single-rooted mandibular premolar teeth were sectioned at the cemento−enamel junction by a diamond disc and were then randomly assigned to four groups of twelve samples each. The groups were irrigated using 5.25% NaOCl, ozonated olive oil, silver citrate, or distilled water. Dentin sections measuring 1.5 mm were obtained from the root portion and each section and were analyzed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and electron-dispersive spectroscopy (EDS). FTIR and EDS values are reported as means ± standard deviations. Data were analyzed using an ANOVA and a post hoc Bonferroni test (p < 0.05). Results: A comparison of the FTIR and EDS values among the groups using ANOVA revealed statistically significant differences in the organic and inorganic peak values among the groups. An intergroup comparison between NaOCl with silver citrate and ozonated olive oil revealed significant reductions in the carbonate and phosphate peak values in the NaOCl group (p < 0.05). The EDS values tabulated for the carbon, oxygen, phosphorous, and calcium peak levels showed significant differences between the groups using an ANOVA. An SEM analysis was conducted under 1500× magnification, which revealed smear layer removal in the silver citrate group. Conclusions: The silver citrate solution and the ozonated olive oil caused less changes in the organic and mineral contents of dentin than sodium hypochlorite.

The effect of humidity and heat environmental conditions on the durability of conventional bamboo materials is a pressing issue in the reserving phase of biomass materials. In this study, the relationship between the main physicochemical, pyrolytic, and mechanical properties of bamboo before and after ageing has been investigated. Exposure of engineered bamboo raw materials with moisture content up to 10% to alternating humidity and heat cycles (20 °C 98% RH-30 °C 64% RH-40 °C 30% RH) of ageing (HHT) causes degradation of the chemical polymer matrix. Byk Gardner 6840 color difference meter, X-ray diffraction, Fourier transform infrared spectroscopy (FTIR), compression intensity, thermogravimetric-infrared spectroscopy (TG-IR), and density changes are used to assess the quality of the material before and after ageing. No significant changes in the moisture content within the range of 6.12 ± 0.327 after two weeks of the engineered bamboo during wet thermal cyclic ageing were determined. However, there were significant differences in mass loss (7.75-9.93 g), cellulose crystallinity, chemical changes, compression strength, and pyrolytic properties. Differences in specimen colors were observed during 10 weeks of the accelerated humidity heat cycling ageing, and TCD variations ranged from 3.75 to 20.08 and from 0.25 and 3.24, respectively. Reduced cellulose crystallinity (36.459-22.638%), axial compressive strength (63.07-88.09 MPa), and modulus of rupture (2409-4286 MPa) were found during aging, whereas deformation and ductility properties were improved. Both natural and humidity heat ageing improve thermal stability and peak pyrolysis rates (0.739-0.931; 0.731-0.797). Humidity heat cyclic ageing will assist in the design and risk assessment of warehousing environments for industrial applications.

The thermal, chemical, and physical properties of compost bedding materials play an important role in every phase of compost production. Based on this, we aimed to assess the thermal, chemical and physical properties of bedding materials for compost-bedded pack (CBP) barns. The database for this study was registered from 42 CBP barns, distributed throughout the state of Kentucky (USA). The thermal conductivity showed a linear relationship with moisture content and bulk density, while thermal resistivity decreased with increasing particle size. The bedding moisture average was 46.8% (±11.5). The average finer index (p < 0.05) was the highest weight percentage (30.1%) in the samples studied. Water-holding capacity (WHC) increased with increasingly fine particle size. The higher bulk density value was 3.6 times that of the lowest bulk density value. The chemical characterization of the bedding material provided the following results: 42.7% (±3.8%) C, 1.6% (±0.4%) N, and 28.2 (±8.0) C:N ratio. However, thermal properties are strongly dependent on particle size. Producers can use the bedding material as fertilizer in their crops, due to the chemical characteristics of the materials. Beds with good physical and chemical properties improve their moisture content.