1. Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation.
- Author
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Gallardo AB, Díaz-Marrero AR, de la Rosa JM, D'Croz L, Perdomo G, Cózar-Castellano I, Darias J, and Cueto M
- Subjects
- Animals, Bridged-Ring Compounds chemistry, Bridged-Ring Compounds isolation & purification, Cell Line, Cell Proliferation drug effects, Furans chemistry, Furans isolation & purification, Magnetic Resonance Spectroscopy, Models, Molecular, Molecular Structure, Oxidation-Reduction, Rats, Anthozoa chemistry, Bridged-Ring Compounds pharmacology, Furans pharmacology, Insulin-Secreting Cells drug effects
- Abstract
Two new chloro-furanocembranolides ( 1 , 2 ) and two new 1,4-diketo cembranolides ( 3 , 4 ) were isolated from the crude extract of Leptogorgia sp. together with a new seco -furanocembranolide ( 5 ) and the known Z -deoxypukalide ( 6 ), rubifolide ( 7 ), scabrolide D ( 8 ) and epoxylophodione ( 9 ). Their structures were determined based on spectroscopic evidence. Four compounds: 1 , 2 , 7 and 8 were found to activate the proliferation of pancreatic insulin-producing (beta) cells., Competing Interests: The authors declare no conflict of interest.
- Published
- 2018
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