1. A Quantitative Comparison of 31 P Magnetic Resonance Spectroscopy RF Coil Sensitivity and SNR between 7T and 10.5T Human MRI Scanners Using a Loop-Dipole 31 P- 1 H Probe.
- Author
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Li X, Zhu XH, and Chen W
- Subjects
- Humans, Radio Waves, Phosphorus Isotopes, Phantoms, Imaging, Signal-To-Noise Ratio, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging instrumentation, Magnetic Resonance Spectroscopy methods, Phosphorus chemistry
- Abstract
In vivo phosphorus-31 (
31 P) magnetic resonance spectroscopy (MRS) imaging (MRSI) is an important non-invasive imaging tool for studying cerebral energy metabolism, intracellular nicotinamide adenine dinucleotide (NAD) and redox ratio, and mitochondrial function. However, it is challenging to achieve high signal-to-noise ratio (SNR)31 P MRS/MRSI results owing to low phosphorus metabolites concentration and low phosphorous gyromagnetic ratio (γ). Many works have demonstrated that ultrahigh field (UHF) could significantly improve the31 P-MRS SNR. However, there is a lack of studies of the31 P MRSI SNR in the 10.5 Tesla (T) human scanner. In this study, we designed and constructed a novel31 P-1 H dual-frequency loop-dipole probe that can operate at both 7T and 10.5T for a quantitative comparison of31 P MRSI SNR between the two magnetic fields, taking into account the RF coil B1 fields (RF coil receive and transmit fields) and relaxation times. We found that the SNR of the31 P MRS signal is 1.5 times higher at 10.5T as compared to 7T, and the power dependence of SNR on magnetic field strength (B0 ) is 1.9.- Published
- 2024
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