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Objective: To evaluate the association between digestive tract cancer and anatomical severity of coronary artery disease. Methods: This study enrolled 142 patients with digestive tract cancer who underwent coronary angiography in the Department of Cardiology of the First Medical Center of Chinese PLA General Hospital from 2009 to 2020 as the cancer group. The patients in cancer group were matched with 426 non-cancer patients who underwent coronary angiography at our hospital during the same period in a 1∶3 ratio based on gender and age. All enrolled patients had no previous history of percutaneous coronary intervention or coronary artery bypass grafting surgery. The severity of coronary artery disease was documented and assessed using the SYNTAX score based on angiogram. High SYNTAX score (SXhigh) was defined as SYNTAX score≥22 (upper quartile), while low SYNTAX score (SXlow) was SYNTAX score<22. High NLR (NLRhigh) was NLR≥2.287 (median), while low NLR (NLRlow) was NLR<2.287. The association between digestive tract cancer and severity of coronary artery disease was analyzed using logistic regression analysis. Results: This study included a total of 568 patients, with a mean age of (66.6±8.7) years. Among them, 430 patients (75.7%) were male. The cancer group consisted of 142 patients with digestive tract cancers, with a mean age of (66.5±8.4) years. The non-cancer group consisted of 426 patients, with a mean age of (66.7±8.8) years. The proportion of SXhigh in patients with digestive tract cancers (33.1%, 47 patients) was higher than that in non-cancer patients (23.9%, 102 patients) ( P =0.032). Compared to non-cancer patients, SXhigh in patients with digestive tract cancers was higher ( OR : 1.614, 95% CI : 1.051-2.481, P =0.029). Subgroup analysis stratified by NLR levels revealed that in the NLRhigh group, patients with digestive tract cancers exhibited a higher severity of coronary artery disease compared to non-cancer patients, with an OR of 1.948 (95% CI : 1.005-3.779, P =0.048). In the NLRlow group, there was no significant relationship between digestive tract cancers and the severity of coronary artery disease, with an OR of 1.277 (95% CI : 0.586-2.781, P =0.538). Conclusions: Digestive tract cancer is associated with the severity of coronary artery disease, and patients with digestive tract cancers have a higher risk of severe coronary artery disease than non-cancer patients. Additionally, there is an association between digestive tract cancers and the severity of coronary artery disease under conditions of high levels of inflammation.

Objective: To investigate the clinical characteristics and related factors of corticosteroid induced adrenal crisis (AC) in children with primary nephrotic syndrome (NS). Methods: Case control study. The case group included 7 children aged 1 to 18 years with NS combined with AC hospitalized in Peking University First Hospital from January 2016 to May 2021 (AC group). According to the ratio of case group: control group 1: 4, 28 children aged 1 to 18 years who were diagnosed with NS without AC during the same period were matched as controls (non-AC group). Clinical data were collected. The clinical characteristics of AC were described. The clinical parameters were compared between the 2 groups by t test, Mann-Whitney U test or Fisher's test. Receiver operating characteristic (ROC) curve was used to analyze the cutoff values of clinical parameters for prediction of AC. Results: The AC group included 4 boys and 3 girls aged 6.9 (4.6, 10.8) years. The non-AC group included 20 boys and 8 girls aged 5.2 (3.3, 8.4) years. All AC events occurred during the relapse of NS with infection. Seven children had gastrointestinal symptoms such as nausea, vomiting and abdominal pain. Six children had poor mental state or impaired consciousness. No significant differences in NS course, corticosteroid treatment course, corticosteroid type, steroid dosage, steroid medication interval, the proportion of gastroenteritis and fever existed between the two groups (all P >0.05). Compared with the non-AC group, the duration from the onset of the relapse of NS until hospitalization in the AC group was significantly shorter (0.2 (0.1, 0.6) vs. 1.0 (0.4, 5.0) month, U =25.50 , P =0.005). The 24 h urinary total protein (UTP) level was significantly higher in the AC group (193 (135, 429) vs. 81 (17, 200) mg/kg, U =27.00 ,P =0.036) than the non-AC group. The serum albumin level in the AC group was significantly lower((13.1±2.1) vs. (24.5±8.7) g/L, t= -6.22, P <0.001) than the non-AC group. There were significantly higher total white blood cell counts ((26±9)×10 9 vs. (11±5)×10 9 /L, t= 4.26, P =0.004), percentage of neutrophils (0.71±0.08 vs. 0.60±0.19, t= 2.56, P =0.017) and the proportion of children with C reactive protein level≥8 mg/L (3/7 vs. 0, P =0.005) in the AC group than in the non-AC group. ROC curve analysis showed that the cutoff value of 24 h UTP was 122 mg/(kg·d) with a sensitivity of 100.0% and specificity of 70.4%. The cutoff value of serum albumin was 17.0 g/L with a sensitivity of 100.0% and specificity of 82.1%. Conclusions: Gastrointestinal symptoms and poor mental state were prominent manifestations of AC in children with NS. High 24 h UTP level, low serum albumin level, high peripheral white blood cell counts, high neutrophils percentage, and high C-reactive protein level during the early stage of NS relapse may be related to the occurrence of AC in children with NS.

Objective: Critically ill patients with solid tumors complicated with paraneoplastic pemphigus are usually treated in intensive care units (ICU) for perioperative management after surgical treatment. In this study, the clinical characteristics and predictors of long-term prognosis of these critically ill patients were analyzed., Methods: the clinical and laboratory data of 63 patients with solid tumors complicated with paraneoplastic pemphigus admitted to ICU from 2005 to 2020 were retrospectively analyzed, and the survival status of the patients were followed up., Results: Among the 63 patients, 79.4% had Castleman disease as the primary tumor, and 20.6% with other pathological types; 69.8% had severe-extensive skin lesions, and 30.2% had other skin lesions; the patients with bronchiolitis obliterans accounted for 44.4%, and 55.6% were not merged. Postoperative fungal infection occurred in 23.8% of the patients, and 76.2% without fungal infection. The median follow-up time was 95 months, and 25 patients died during the study period. The 1-year, 3-year and 5-year survival rates were 74.6% (95% CI 63.8%-85.4%), 67.4% (95% CI 55.6%-79.2%) and 55.1% (95% CI 47.9%-62.3%), respectively. The log-rank univariate analysis showed that the patients had age>40 years ( P =0.042), preoperative weight loss>5 kg ( P =0.002), preoperative albumin < 30 g/L ( P < 0.001), paraneoplastic pemphigus complicated with bronchiolitis obliterans ( P =0.002), and perioperative fungal infection ( P < 0.001) had increased mortality. Cox univariate analysis showed that preoperative weight loss >5 kg ( P =0.005), preoperative albumin < 30 g/L ( P < 0.001), paraneoplastic pemphigus complicated with bronchiolitis obliterans ( P =0.009), preoperative bacterial pulmonary infection ( P =0.007), prolonged surgical time ( P =0.048), postoperative oxygenation index ( P =0.012) and low albumin ( P =0.010) and hemoglobin concentration ( P =0.035) in ICU, acute physiology and chronic health evaluation (APACHE Ⅱ) score ( P =0.001); sequential organ failure assessment (SOFA) score ( P =0.010), and postoperative fungal infection ( P < 0.001) were risk factors for long-term survival. Cox regression model for multivariate analysis showed that preoperative weight loss > 5 kg ( HR 4.44; 95% CI 1.47-13.38; P =0.008), and preoperative albumin < 30 g/L ( HR 4.38; 95% CI 1.72-11.12; P =0.002), bronchiolitis obliterans ( HR 2.69; 95% CI 1.12-6.50; P =0.027), and postoperative fungal infection ( HR 4.85; 95% CI 2.01-11.72; P < 0.001) were independent risk factors for postoperative mortality., Conclusion: The 5-year survival rate of critically ill patients undergoing surgery for paraneoplastic pemphigus combined with solid tumors is approximately 55.1%, with preoperative weight loss > 5 kg, albumin < 30 g/L, bronchiolitis obliterans and postoperative fungal infection were associated with an increased risk of near- and long-term postoperative mortality.

Objective: To investigate the clinical outcomes of different treatment options on singleton short cervix and its influence factors. Methods: Totally 435 cases of singleton pregnancies who were diagnosed with short cervix (≤25 mm) between 12 to 33 +6 gestational weeks in Peking University First Hospital from January 2018 to December 2018 were enrolled, including 21 cases with cervical length <10 mm, 414 cases with cervical length between 10 to 25 mm. The onset time was <24 gestational weeks in 106 cases, while 104 cases were at 24-29 +6 gestational weeks and 225 cases of ≥30 gestational weeks. Gestational outcomes including delivery before 37 weeks, delivery before 34 weeks, neonatal birth weight (NBW) and adverse neonatal outcome (ANO) were compared among three treatment groups: rest group, progesterone group and cerclage group. Influence factors were also investigated. Results: (1) The incidence of short cervix in pregnancy was 7.07% (435/6 155), while 106 cases were at <24 gestational weeks (1.72%, 106/6 155), 104 cases (1.69%, 104/6 155) at 24-29 +6 gestational weeks and 225 cases (3.66%, 225/6 155) at ≥30 gestational weeks. (2) In the group of cervical length <10 mm, rate of delivery before 37 and 34 weeks were 62% (13/21) and 57% (12/21) respectively. One case of progesterone treatment underwent miscarriage. Compared with rest group ( n =8), delivery weeks [28.5 (25.0-40.0) vs 37.0 (28.0-40.0), P =0.020] and NBW [1 245 g (630-3 830 g) vs 2 648 g (1 560-3 830 g), P =0.028] were higher in cerclage group ( n =9), while ANO was not statistically different ( P >0.05). (3) In the group of cervical length ≥10 mm before 24 gestational weeks, the delivery weeks, incidence of delivery before 34 weeks, adjusted incidence of delivery before 37 weeks, NBW and ANO were not statistically different ( P >0.05) among rest group ( n =36), progesterone group ( n =26) and cerclage group ( n =34). In vitro fertilization ( OR =11.97, 95% CI : 1.88-76.44, P =0.009), infection ( OR =46.03, 95% CI : 5.12-413.58, P =0.001), sludge on sonography ( OR =9.87, 95% CI : 1.69-57.60, P =0.011) and history of short cervix ( OR =7.24, 95% CI : 1.04-50.24, P =0.045) were independent risk factors of preterm birth. (4) In the group of cervical length ≥10 mm and gestational weeks between 24-29 +6 , the delivery weeks, incidence of delivery before 37 weeks, incidence of delivery before 34 weeks, NBW and ANO were not statistically different ( P >0.05) among rest group ( n =52), progesterone group ( n =34) and cerclage group ( n =9). Infection was an independent risk factor of preterm birth ( OR =56.40, 95% CI : 4.67-680.61, P =0.002). (5) Outcomes of 223 cases were relatively good in the group of cervical length ≥10 mm beyond 30 gestational weeks. The incidence of delivery before 34 weeks was 6.3% (14/223). The delivery weeks, incidence of delivery before 37 and 34 weeks, NBW and ANO were not statistically different ( P >0.05) among 3 groups. Infection ( OR =10.91, 95% CI : 2.21-53.96, P =0.003) and history of preterm birth ( OR =8.63, 95% CI : 1.25-59.65, P =0.029) were independent risk factors of preterm birth. Conclusions: Short cervix is a common complication of pregnancy. Cervical cerclage is related with better outcome for patients with cervical length <10 mm. Neither progesterone nor cervical cerclage improves pregnancy outcome for >10 mm cervical length patients comparing with rest. Infection, sludge, in vitro fertilization, history of short cervix and history of preterm birth are independent risk factors of preterm birth in short cervix pregnancies.

Objective: To investigate the effects of intraoperative hemodynamic instability on postoperative complications of laparoscopic surgery for pheochromocytoma. Methods: It was a retrospective cohort study. According to inclusion/exclusion criteria, adult patients underwent laparoscopic surgery for pheochromocytoma from January 2005 to December 2017 in Peking University First Hospital were enrolled in this study. Eligible patients were divided into two groups by evidence of postoperative complications to find out the effects of intraoperative hemodynamic instability and its' effects on other prognostic indices. The normally distributed continuous variables were compared between two groups by Student's t test, Mann-Whitney U test were used for the comparison for non-normally distributed continuous variables and χ(2) test for categorical variables. Results: A total of 198 patients were finally enrolled in this study, including 87 males and 111 females with an average age of (47±15) years. Postoperative complications occurred in 17 patients with an incidence of 8.6%, and intraoperative hemodynamic instability occurred in 45 patients (22.7%). It was found that history of stroke[odds ratio ( OR )=13.387, 95% confidence interval ( CI ): 2.284-78.460, P =0.004], intraoperative hemodynamic instability ( OR =3.351, 95% CI: 1.119-10.039, P =0.031) and intraoperative positive fluid balance (for each additional 100 ml) ( OR =1.087, 95% CI: 1.031-1.146, P =0.002)were the independent risk factors of postoperative complications of laparoscopic surgery for pheochromocytoma. Furthermore, more postoperative complications, higher rate of admitting to ICU and longer hospital stay was found in patients with hemodynamic instability. Conclusion: Intraoperative hemodynamic instability is an independent risk factor for postoperative complications of laparoscopic surgery in patients with pheochromocytoma, and it associates with more postoperative complications and higher rate of admitting to ICU.

Background: The choice of general anaesthetics may affect postoperative cognitive outcomes. This study was designed to compare the potential impact of propofol-based vs sevoflurane-based general anaesthesia on the development of delayed neurocognitive recovery in older adults early after major cancer surgery., Methods: Older adults (aged ≥65 and <90 yr) who were scheduled to undergo major cancer surgery (≥2 h) were randomised to receive either propofol- or sevoflurane-based general anaesthesia. Cognitive function was assessed before and 1 week after surgery with a battery of neuropsychological tests. Age- and education-matched non-surgical controls were recruited, and their cognitive functions were tested at comparable time intervals in order to adjust for learning effects from repeated tests. Delayed neurocognitive recovery was diagnosed according to the International Study of Postoperative Cognitive Dysfunction 1 definition., Results: From April 1, 2015 to October 15, 2016, 392 patients were enrolled and randomised. Of these patients, 387 completed the intervention and 30-day follow-up, and 379 completed 1-week neuropsychological tests. Fifty-nine control subjects were enrolled and completed repeated neuropsychological tests. The incidence of delayed neurocognitive recovery at 1 week was significantly lower in the propofol group [14.8% (28/189)] than in the sevoflurane group [23.2% (44/190); odds ratio=0.577; 95% confidence interval, 0.342-0.975; P=0.038]. Safety outcomes did not differ between the two groups., Conclusions: When compared with sevoflurane-based general anaesthesia, propofol-based general anaesthesia might decrease the incidence of delayed neurocognitive recovery in older adults after major cancer surgery., Clinical Trials Registration: NCT02662257; Chinese Clinical Trial Registry (identifier: ChiCTR-IPR-15006209)., (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Background: Vitamin D is important for maintaining physiological functions including cognition and its deficiency is associated with the occurrence of cognitive impairment. This study was to explore the association between preoperative vitamin D status and the occurrence of postoperative cognitive dysfunction (POCD) in elderly patients undergoing major surgery., Methods: This was a predefined exploratory sub-analysis of one-centre data from a randomized controlled trial. In all, 123 elderly (≥ 65 years) patients who were scheduled to undergo major cancer surgery were recruited. Serum 25-hydroxyvitamin D concentration was measured before surgery. In total, 59 nonsurgical control subjects with comparable age and education level were also enrolled. A battery of neuropsychological tests was administered the day before and the 7th day after surgery in patients or at the same time interval in control subjects. POCD was diagnosed according to the ISPOCD1 definition., Results: 71.5% (88/123) of elderly patients had vitamin D deficiency (serum 25-hydroxyvitamin D concentration < 12 ng/ml) before surgery; 24.4% (30/123) of them developed cognitive dysfunction at 1 week after surgery. After adjusting for confounding factors, high preoperative serum 25-hydroxyvitamine D concentration was related to a decreased risk of POCD (odds ratio [OR]: 0.829, 95% confidence interval [CI]: 0.708-0.971; P = 0.020), whereas preoperative vitamin D deficiency was associated with an increased risk of POCD (OR: 8.427, 95% CI: 1.595-44.511; P = 0.012)., Conclusions: Vitamin D deficiency is prevalent in elderly patients undergoing major cancer surgery and increases the risk of early POCD development. Whether prophylactic vitamin D supplementation can reduce POCD in the elderly deserves further study., (© 2018 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.)

Objective: To prospectively investigate the changes in nutritional status of patients with malignant tumors during hospitalization by using nutritional risk screening (NRS2002), and to analyze the correlation between the nutritional status and clinical outcomes . Methods: This was a prospective and parallel research done by multi-center collaboration from 34 hospitals in China from June to September 2014.Hospitalized patients with malignant tumors inthese departments (Department of Gastroenterology, respiratory medicine, oncology, general surgery, thoracic surgery and geriatrics)were investigated. Only the patients with age≥ 18 years and hospitalization time between 7-30 days were included. During hospitalization, the physical indexes of human bodywere measured, and the NRS 2002 scores, and monitored the nutritional support at the time points of admission and 24 hours before discharge were recorded.And whether there was a nutritional risk in hospitalized patients and its association with clinical outcomes were investigated. Results: A total of 2 402 patients with malignancies were enrolled in this study. Seventy fourpatients who did not complete NRS2002 were eliminated, and 2 328 patients were included. The number of the main diseases was the top five, including 587 cases of colorectal cancer, 567 cases of lung cancer, 564 cases of gastric cancer, 146 cases of esophageal cancer, and 119 cases of liver tumor. At the time of discharge, compared with admission, the BMI, body weight, grip and calf circumferences of patients with malignant tumor were significantly decreased ( P <0.05). The total protein, albumin, prealbumin and hemoglobin were significantly lower than those at admission ( P <0.05). In 2 328 patients who were completed nutritional risk screening, the rate of malnutrition at admission was 11.1% (BMI =18.5, 258/2 328) and the rate of malnutrition at discharge was 10.9% (BMI =18.5, 254/2 328), there were no significant differences (χ(2)=0.019 7, P =0.888). There were 1 204 patients with nutritional risk at admission (51.7%, NRS2002 score≥3)and 1 352 patients with nutritional risk at discharge (58.1%, NRS2002 score≥3), with significant differences (χ(2)=49.9, P <0.001). The incidence of nutritional risk in patients with colorectal, stomach, and lung tumors at discharge was significantly higher than that at admission ( P <0.05). The infective complications and other complications of patients with nutritional risk were significantly greater than those without nutritional risk at admission and at discharge.ICU hospitalization stay of patients with nutritional risk was increased significantly than those without nutritional risk at admission( P =0.042). Hospitalization expenses of patients with nutritional risk was increased significantly than those of patients without nutritional risk at discharge( P <0.01). Conclusion: The patients with malignant tumor have a higher incidence rate of malnutrition at both admission and discharge and malnutritionhas correlation with adverse clinical outcomes.The aboveindicators did not improve significantly at discharge.Doctors should pay more attention to the nutritional status (screening and evaluation)of patients before discharge and use appropriate and adequate nutrition support in order to prevent the weight loss and improve the life quality of patients.

Objective: To analyze docetaxel (T) and carboplatin (C) combined with trastuzumab (H) -TCH regimen as neoadjuvant systemic therapy in early breast cancer patients with human epidermal growth factor receptor 2 (HER-2) positive. Methods: From January 2008 to December 2014, the data of patients diagnosed as early breast cancer in Breast Disease Center of Peking University First Hospital were retrospective reviewed. The data of patients with HER-2 positive conducted TCH neoadjuvant therapy and surgery, and with the complete clinicopathological information were analyzed. Results: A total of 77 cases were enrolled in this study. We defined G2+ G3+ G4+ G5 as responsive group according to Miller-Payne grading system, the responsive rate was 84.4% (65/77). The rate of complete pathological remission (pCR) was 39.0% (30/77). The 5-year disease free survival (DFS) was 87.3%, and 5-year overall survival (OS) was 93.6%. There was a significant difference between DFS and OS in the responsive group and non-responsive group (DFS: χ 2 =6.762, P =0.009; OS: χ 2 =5.062, P =0.024). Conclusion: TCH is an effective neoadjuvant therapy for patients with HER-2 positive breast cancer, and the toxic and side effects were under control.

Details of various composites of the projections originated from a fundamental group-velocity-locked vector dissipative soliton (GVLVDS) are both experimentally and numerically explored. By combining the projections from the orthogonal polarization components of the GVLVDS, a high-order vector soliton structure with a double-humped pulse profile along one polarization and a single-humped pulse profile along the orthogonal polarization can be observed. Moreover, by de-chirping the composite double-humped pulse, the time separation between the two humps is reduced from 15.36 ps to 1.28 ps, indicating that the frequency chirp of the GVLVDS contributes significantly to the shaping of the double-humped pulse profile.

We experimentally demonstrate multiple generations of high-order orbital angular momentum (OAM) modes through third-harmonic generation in a 2D nonlinear photonic crystal. Such third-harmonic generation process is achieved by cascading second-harmonic generation and sum-frequency generation using the non-collinear quasi-phase-matching technique. This technique allows multiple OAM modes with different colors to be simultaneously generated. Moreover, the OAM conservation law guarantees that the topological charge is tripled in the cascaded third-harmonic generation process. Our method is effective for obtaining multiple high-order OAM modes for optical imaging, manipulation, and communications.

Objective: To evaluate the feasibility of transforaminal endoscopic nerve root decompression for degenerative lumbar spinal stenosis (DLSS)., Methods: From July 2011 to April 2016, 96 cases of single segment DLSS were involved. All the patients had unilateral lower extremity neurological symptoms, signs, neurogenic intermittent claudication of less than 500 m. Imaging examinations (CT or MRI) or diagnostic nerve root block confirmed single segment degeneration. The mean age was (71.6±5.4) years, male: 55 cases, female: 41 cases. Their intraoperative blood loss, operation time, complications, ambulation time and discharge time were recorded. Leg pain VAS, ODI were used to evaluate the pain and lumbar function of the patients. The clinical efficacy was evaluated by Nakai evaluation., Results: All the patients were performed endoscopic decompression of the lateral recess and nerve root by removing the ventral part of the superior facet joint, the ligamentum flavum and the intervertebral disc. The decompression range was from the inferior edge of the upper pedicle to the superior edge of the lower pedicle. The nerve root was detected to have no compression and the pulse of nerve root returned to normal. The patient got ambulant on the operation day and discharged if he had no discomfort symptom. In the study, 68 cases got follow up. The mean follow-up time was 12.1 months (6-63 months). The VAS at different follow-up time points was improved relative to the baseline, and the difference was statistically significant (F=491.60, P<0.001). The ODI at different follow-up time points was improved relative to the baseline, and the difference was statistically significant (F=189.91, P<0.001). The excellent and good rates of Nakai evaluation were 79.4% (excellent in 42 cases, good in 12 cases, fair in 10 cases and poor in 4 cases). The mean intraoperative blood loss was (49.29±11.86) mL. The mean operation time was (92.46±21.34) min. The mean ambulation time was 1.8 h. The mean discharge time was 2.3 days. Postoperative epidural hematoma was found in 1 case. Foot drop was found in 1 case. Second stage open surgery was performed in 6 cases., Conclusion: We can apply transforaminal endoscopic decompression for the patients of lumbar spinal stenosis who have unilateral nerve root irritation. Patients with transforaminal endoscopic decompression can get less surgical trauma, quick recovery and obtain good short-term outcome.

Objective: To evaluate changes in nutritional status of hospitalized patients with different diseases by subjective global assessment (SGA) and nutritional risk screening (NRS-2002). Methods: A prospective and parallel research done by multi-center collaboration from 34 hospitals in China from June to September 2014. Hospitalized patients with the following diseases were investigated: malignant tumor (2 487 cases), benign disease of the digestive system (1 358 cases), benign disease of the nervous system (1 043 cases), benign bone disease (451 cases), benign disease of the respiratory system(395 cases), cardiovascular disease (227 cases), benign thyroid and breast disease (179 cases), and endocrine disease (149 cases). Patients above the age of 18 and hospitalization time between 7-30 days were included. Physical indexes were measured, the NRS-2002 and SGA scores were recorded, the nutritional support were recorded during hospitalization and 24 hours after discharge from hospital. Measurement data between groups were analyzed using t test or Wilcoxon rank sum test, enumeration data and ranked data between groups were analyzed using chi-square test or Fisher exact test. Results: There were 6 638 cases of hospitalized patients, 3 861 cases were males and 2 777 were females, the male/female ratio was 1.4∶1.0; the median age was 60 years; the median height was 1.66 m; the median weight was 62 kg; the median body mass index (BMI)was 22.89 kg/m(2). At discharge, compared with that of admission, the body weight, BMI, grip strength, upper arm and calf circumferences of patients with malignant tumor were significantly decreased ( t =20.15-259.67, all P <0.01); the body weight and calf circumference were significantly decreased ( t =35.27, 60.40, P <0.01)of patients with digestive benign disease; the body weight of patients with benign bone diseases was decreased ( t =2.12, P =0.033); the body weight, grip strength and upper arm circumference were decreased in patients with benign thyroid and breast disease ( t =2.79-10.18, all P <0.01); nutritional risk incidence rate (from NRS-2002) of patients with malignant tumor was significantly higher(χ(2)=21.275, P =0.000); moderate malnutrition (from SGA) incidence rate was significantly higher(χ(2)=62.318, P =0.000; χ(2)=11.312, P <0.01) in patients with malignant tumor and with orthopedics diseases. Compared with that of admission, records of the patients with other diseases had no statistically difference at discharge, no more than 50% of the patients under risk of nutritional deficiency(except those with digestive benign diseases )received nutritional support, while the proportion of non-parenteral nutrition application was higher. Conclusion: The patients with malignant tumor have higher incidence rate of malnutrition on admission and at discharge. Doctors should pay more attention to the nutritional status(screening and evaluation) of patients before discharge and use appropriate and adequate nutrition support in order to prevent the weight loss and improve the life quality of patients.

Our experiment shows that the thermal emission of phonon can be controlled by magnetic resonance (MR) mode in a metasurface (MTS). Through changing the structural parameter of metasurface, the MR wavelength can be tuned to the phonon resonance wavelength. This introduces a strong coupling between phonon and MR, which results in an anticrossing phonon-plasmons mode. In the process, we can manipulate the polarization and angular radiation of thermal emission of phonon. Such metasurface provides a new kind of thermal emission structures for various thermal management applications., Competing Interests: The authors declare no competing financial interests.

Diffraction-free beams have attracted increasing research interests because of their unique performances and broad applications in various fields. Although many methods have been developed to produce such beams, it is still challenging to realize a tunable non-diffracting beam. Here, we report the generation of a tunable diffraction-free array through second-harmonic generation in a nonlinear photonic crystal, i.e., a 2D periodically-poled LiTaO 3 crystal. In such a crystal, the second-harmonic wave is engineered by properly designing the domain structure based on the Huygens-Fresnel principle. The characteristics of the generated diffraction-free array including its period, propagation length, and wavelength can be tuned by simply changing the input wavelength. Our observation not only enriches the diffraction-free optics, but also has potential applications for photolithography and imaging.

Recent advances in controlling the optical phase at the sub-wavelength scale by meta-structures offer unprecedented possibilities in the beam engineering, holograms, and even invisible cloaks. In despite of developments of plasmonic beam engineering for definite beams, here, we proposed a new holographic strategy by in-plane diffraction process to access indefinite plasmonic beams, where a counterintuitive oscillating beam was achieved at a free metal surface that is against the common recognition of light traveling. Beyond the conventional hologram, our approach emphasizes on the phase correlation on the target, and casts an in-depth insight into the beam formation as a kind of long depth-of-field object. Moreover, in contrast to previous plasmonic holography with space light as references, our approach is totally fulfilled in a planar dimension that offers a thoroughly compact manipulation of the plasmonic near-field and suggests new possibilities in nanophotonic designs.

Photonic quantum information processing system has been widely used in communication, metrology and lithography. The recent emphasis on the miniaturized photonic platform is thus motivated by the urgent need for realizing large-scale information processing and computing. Although the integrated quantum logic gates and quantum algorithms based on path encoding have been successfully demonstrated, the technology for handling another commonly used polarization-encoded qubits has yet to be fully developed. Here, we show the implementation of a polarization-dependent beam-splitter in the hybrid waveguide system. With precisely design, the polarization-encoded controlled-NOT gate can be implemented using only single such polarization-dependent beam-splitter with the significant size reduction of the overall device footprint to 14 × 14 μm(2). The experimental demonstration of the highly integrated controlled-NOT gate sets the stage to develop large-scale quantum information processing system. Our hybrid design also establishes the new capabilities in controlling the polarization modes in integrated photonic circuits.

We propose to generate a single-mode-squeezing two-mode squeezed vacuum state via a single χ (2) nonlinear photonic crystal. The state is favorable for existing Gaussian entanglement distillation schemes, since local squeezing operations can enhance the final entanglement and the success probability. The crystal is designed for enabling three concurrent quasi-phase-matching parametric-down conversions, and hence relieves the auxiliary on-line bi-side local squeezing operations. The compact source opens up a way for continuous-variable quantum technologies and could find more potential applications in future large-scale quantum networks.

We experimentally demonstrate the orbital angular momentum (OAM) conversion by the coupled nonlinear optical processes in a quasi-periodically poled LiTaO3 crystal. In such a crystal, third-harmonic generation (THG) is realized by the coupled second-harmonic generation (SHG) and sum-frequency generation (SFG) processes, i.e., SHG is dependent on SFG and vice versa. The OAMs of the interacting waves are proved to be conserved in such coupled nonlinear optical processes. As we increase the input OAM in the experiment, the conversion efficiency decreases because of the reduced fundamental power density. Our results provide better understanding for the OAM conversions, which can be used to efficiently produce an optical OAM state at a short wavelength.

We introduce a cross plasmonic antenna (CPA) for the system of multiple quantum emitters (QEs) with different emission wavelengths, where the excitation light scattering and emission fluorescence of different QEs are spatially separated in four different directions. By considering the CPA as oscillating dipoles, this phenomenon is attributed to the phase differences between them. The enhancement for QEs are very strong in correponding directions. In addition, the fluorescence is strongly polarized. By adding a silver plate as substrate, the directivity can be further tuned in the whole upper half space. Our result shows that the CPA is promising for realization of an efficient, directional and strongly polarized nano-scale light source, which will have potential application in Nano-Optics.

We report a compact scheme for the generation and manipulation of photon pairs entangled in the orbital angular momentum (OAM) from the fork-poling quadratic nonlinear crystal. The χ (2) -modulation in this crystal is designed for fulfilling a tilted quasi-phase-matching geometry to ensure the efficient generation of entangled photons as well as for transferring of topological charge of the crystal to the photon pairs. Numerical results show that the OAM of photon pair is anti-correlated and the degree of OAM entanglement can be enhanced by modulating the topological charge of crystal, which indicates a feasible extension to high-dimensional OAM entanglement. These studies suggest that the fork-poling nonlinear photonic crystal a unique platform for compact generation and manipulation of high-dimensional and high-order OAM entanglement, which may have potential applications in quantum communication, quantum cryptography and quantum remote sensing.

A consequent tendency toward high-performance quantum information processing is to develop the fully integrated photonic chip. Here, we report the on-chip generation and manipulation of entangled photons based on reconfigurable lithium-niobate waveguide circuits. By introducing a periodically poled structure into the waveguide circuits, two individual photon-pair sources with a controllable electro-optic phase shift are produced within a Hong-Ou-Mandel interferometer, resulting in a deterministically separated identical photon pair. The state is characterized by 92.9±0.9% visibility Hong-Ou-Mandel interference. The photon flux reaches ∼1.4×10(7)  pairs nm-1 mW-1. The whole chip is designed to contain nine similar units to produce identical photon pairs spanning the telecom C and L band by the flexible engineering of nonlinearity. Our work presents a scenario for on-chip engineering of different photon sources and paves the way to fully integrated quantum technologies.

We report a simple, novel subdiffraction method, i.e. diffraction interference induced superfocusing in second-harmonic (SH) Talbot effect, to achieve focusing size of less than λSH/4 (or λpump/8) without involving evanescent waves or subwavelength apertures. By tailoring point spread functions with Fresnel diffraction interference, we observe periodic SH subdiffracted spots over a hundred of micrometers away from the sample. Our demonstration is the first experimental realization of the Toraldo di Francia's proposal pioneered 62 years ago for superresolution imaging.

A mode division multiplexer (MDM) based on in-plane diffractions is experimentally demonstrated in a polymer-loaded plasmonic planar waveguide. Three guided modes (TM₁, TE₁, and TM₂) were well demultiplexed by a focusing design with a focal length of about 40 μm, which are clearly distinguished by the polarization control. The experimental results well reproduced the theoretical design and calculation. Moreover, the demultiplexed focal spots directly reflect the different modes, by which a mode diagram of the dielectric-loaded planar waveguide was vividly mapped out by varying the polymer layer thickness. In this regard, the proposed device may not only serve as a MDM for the integrated optics but can also provide a new strategy in analyzing the guided modes.

We experimentally investigated concurrent parametric downconversion processes in a two-dimensional hexagonally poled lithium tantalate crystal. The substantial enhancement of parametric gain was observed when concurrent processes shared a common parametric beam. Both degenerate and nondegenerate concurrent parametric downconversion processes were studied. Analyses of the spatial forms and output angles showed a strong dependence on the working temperature, during which a well-defined beamlike parametric output was observed. Our results will stimulate the design for coherent high-gain generation of multiple parametric beams and also shed light on the compact engineering of path-entanglement with specific spatial forms based on concurrent spontaneous parametric downconversion processes.

In this work we present a refractive index sensor based on the leaky radiation of a microfiber. The 5.3um diameter microfiber is fabricated by drawing a commercial optical fiber. When the microfiber is immersed into a liquid with larger refractive index than the effective index of fiber mode, the light will leak out through the leaky radiation process. The variation of refractive index of liquid can be monitored by measuring radiation angle of light. The refractive index sensitivity can be over 400 degree/RIU in theory. In the experiment, the variation value 0.001 of refractive index of liquid around this microfiber can be detected through this technique. This work provides a simple and sensitive method for refractive index sensing application.

We report a diode-pumped intracavity second-harmonic generation mode-locked solid-state Tm:YAP laser operating at 1988 nm using a periodically poled congruent LiNbO3 as the nonlinear crystal. The threshold of continuous wave mode locking is 11.6 W. The maximum output power is 1.67 W, while the shortest pulse obtained is 4.7 ps at a repetition rate of 97.09 MHz.

An integrated realization of photonic entangled states becomes an inevitable tendency toward integrated quantum optics. Here we report the compact engineering of steerable photonic path-entangled states from a monolithic quadratic nonlinear photonic crystal. The crystal acts as a coherent beam splitter to distribute photons into designed spatial modes, producing the heralded single-photon and appealing beamlike two-photon path entanglement. We characterize the path entanglement by implementing quantum spatial beating experiments. Such a multifunctional entangled source can be further extended to the high-dimensional fashion and multiphoton level, which paves a desirable way to engineering miniaturized quantum light sources.

We demonstrate the improved second-harmonic Talbot self-imaging through the quasi-phase-matching technique in a 2D periodically-poled LiTaO(3) crystal. The domain structure not only composes a nonlinear optical grating which is necessary to realize nonlinear Talbot self-imaging, but also provides reciprocal vectors to satisfy the phase-matching condition for second-harmonic generation. Our experimental results show that quasi-phase-matching can improve the intensity of the second-harmonic Talbot self-imaging by a factor of 21.

Since cavity-phase matching has been experimentally realized, the efficiency is limited to 20%. In this Letter, we successfully achieved a conversion efficiency as high as 41% with a slope efficiency of 48.5% using cavity-phase matching, by reflecting the pump beam at the end surface of the KTiOPO(4) crystal. The high performance of the device makes it a promising candidate to substitute for quasi-phase-matching material.

A well-developed phase modulation method is utilized to design a nanogroove grating for a desired diffraction process, which gives rise to the conversion of a surface plasmon wave to an Airy-like radiation beam. Experiments and simulations revealed the unique characteristics of the generated Airy-like beam, such as nonspreading, self-bending, and self-healing. Our result confirms the validation of the diffraction strategy for beam engineering in conversions and possibly indicates wider applications in broader areas.

We propose a compact scheme for the heralded generation of single-photon multipartite entanglement by using a single two-dimensional nonlinear photonic crystal. Studies have shown that by appropriate structure design, the single-photon entanglement shared among three spatially distinct optical modes can be generated through three concurrent spontaneous parametric down-conversion processes by using the other photon in an identical spatial mode as a trigger. Furthermore, we analyze the entanglement of such heralded single-photon tripartite W-type state theoretically. This method can be expanded for the heralded single-photon N-partite entanglement generation. This compact and stable quantum light source may act as a key ingredient in quantum information science.

We worked out a new group of collimated plasmon beams by the means of in-plane diffraction with symmetric phase modulation. As the phase type changes from 1.8 to 1.0, the beam undergoes an interesting evolution from focusing to a straight line. Upon this, an intuitive diagram was proposed to elucidate the beam nature and answer the question of whether they are nondiffracting or linear focusing. Based on this diagram, we further achieved a highly designable scheme to modulate the beam intensity (e.g., "lossless" plasmon). Our finding holds remarkable generality and flexibility in beam engineering and would inspire more intriguing photonic designs.

An electrical pumped microscopic active display with integration of plasmonic polarizer and light-emitting-diode is proposed. Thanks to the strong polarized emission through the rectangular nanoholes, well designed pixels with respect to different polarizations are engineered, which give rise to flexible and controllable active display. As results, polarization multiplexed letter encoding, single and double gray-scale images and animation movies are successfully realized. Our results demonstrate a new strategy in electro-optical integration and indicate potential applications in designing new type of microscopic electro-optical devices.

We extend the phase modulation method by in-plane diffractions from plane wave incidence to point source of surface plasmon polariton (SPP). A well-defined SPP focus is successfully realized from a point source under the diffraction by a carefully designed nanohole array, which is easy to layout in the future integrated optical circuits. With this method, the SPP Airy beam and finite plane wave are demonstrated as well, proving a general applicability of this modulation method. The proposed method and realized functions are expected of benefits for the future integration optics.

We propose a scheme for generating polarization-entangled photon pairs using a χ((2)) nonlinear photonic crystal, which is designed for enabling two concurrent quasi-phase-matched spontaneous parametric downconversion processes. Beamlike photon pairs produced from each process are collinear but noncollinear with the pump. Moreover, the source we design works in a postselection-free way and applies to both degenerate and nondegenerate cases. Combining possible waveguide technologies, our scheme may provide an integrated polarization entanglement source.

We demonstrate that a transformation device can be emulated using a gradient-index waveguide. The effective index of the waveguide is spatially varied by tailoring a gradient thickness dielectric waveguide. Based on this technology, we demonstrate a transformation device guiding visible light around a sharp corner, with low scattering loss and reflection loss. The experimental results are in good agreement with the numerical results.

We experimentally demonstrated an electrically excited surface plasmon source, which was fulfilled in a silver coated light emitting diode (LED) with well-designed gratings. With a DC current supply, surface plasmon polariton (SPP) waves were generated directly from the illuminations of the LED via the grating coupler. By adjusting the grating to a tilted one, a unidirectional SPP beam was successfully attained with a high extinction ratio (ER~10) and an improved launching efficiency. Detailed analyses show that this electrically generated unidirectional SPP has a considerable long propagation distance (~14 μm), allowing for further manipulations in plasmonic integrations and sensors.

We studied the quantum properties of magnetic plasmon waves in a three-dimensional coupled metamaterial. A Hong-Ou-Mandel dip of two-photon interference with a visibility of 86 ± 6.0% was explicitly observed, when the sample was inserted into one of the two arms of the interferometer. This meant that the quantum interference property survived in such a magnetic plasmon wave-mediated transmission process, thus testifying the magnetic plasmon waves owned a quantum nature. A full quantum model was utilized to describe our experimental results. The results showed that the metamaterials could not only steer the classical light but also the non-classical light and they might have potential application in the future quantum information.

We demonstrate the fractional second-harmonic (SH) Talbot effect in a hexagonally poled LiTaO3 crystal. We carefully record the SH Talbot images at 1/2, 1/3, and 1/4 Talbot lengths, which are well matched with the simulated images by using the modified Rayleigh-Sommerfeld diffraction formula. A simplified model with a hexagonal array is adopted in the simulations. Also, we use a modified reciprocal vector theory to analytically explain the evolution of the SH array at fractional Talbot lengths. Our results show that the images are sensitive to the duty circle and the background of the array.

A coupled magnetic resonator waveguide, composed of a contacting gold nanosphere chain on a gold slab, is proposed and investigated. A broadband coherent magnetic plasmon mode can be excited in this one dimensional nanostructure. By employing the Lagrangian formalism and the Fourier transform method, the dispersion properties of the wave vector and group velocity of the magnetic plasmon mode are investigated. Small group velocity can be obtained from this system which can be applied as subwavelength slow wave waveguides., (© 2011 Optical Society of America)

We report an experimental realization of a plasmonic Airy beam, which is generated thoroughly on a silver surface. With a carefully designed nanoarray structure, such Airy beams come into being from an in-plane propagating surface plasmon polariton wave, exhibiting nonspreading, self-bending, and self-healing properties. Besides, a new phase-tuning method based on nonperfectly matched diffraction processes is proposed to generate and modulate the beam almost at will. This unique plasmonic Airy beam as well as the generation method would significantly promote the evolutions in in-plane surface plasmon polariton manipulations and indicate potential applications in lab-on-chip photonic integrations.

We theoretically studied a nonlinear optical process in a hybrid plasmonic waveguide composed of a nonlinear dielectric waveguide and a metal film with a separation of a thin air gap. Owing to the hybridization effect of guided mode and surface plasmon polariton mode, this particular waveguide is able to confine the optical-field in a deep subwavelength scale together with low propagation loss. Based on this, efficient second-harmonic generations (SHG) were revealed at the fundamental wavelength of λ=1.55 μm with good field confinement. The SHG efficiency, as well as the coupling coefficient and mode area, were analyzed and discussed in detail with respect to the structural parameters.

We report an efficiency-enhanced mid-infrared generation via optical parametric down conversion. A tandem periodically-poled MgO-doped stoichiometric lithium tantalate crystal is used to realize on-chip generation and amplification of mid-infrared radiation inside an optical parametric oscillator cavity. We achieved 21.2% conversion efficiency (24% slope efficiency), which is among the highest efficiencies for the pump-to-mid-infrared conversion, with 1064 nm Nd class laser pump. The maximum average output power at 3.87 μm reached 635 mW with a 3.0 W pump.

One promising technique for working toward practical photonic quantum technologies is to implement multiple operations on a monolithic chip, thereby improving stability, scalability and miniaturization. The on-chip spatial control of entangled photons will certainly benefit numerous applications, including quantum imaging, quantum lithography, quantum metrology and quantum computation. However, external optical elements are usually required to spatially control the entangled photons. Here we present the first experimental demonstration of on-chip spatial control of entangled photons, based on a domain-engineered nonlinear photonic crystal. We manipulate the entangled photons using the inherent properties of the crystal during the parametric downconversion, demonstrating two-photon focusing and beam-splitting from a periodically poled lithium tantalate crystal with a parabolic phase profile. These experimental results indicate that versatile and precise spatial control of entangled photons is achievable. Because they may be operated independent of any bulk optical elements, domain-engineered nonlinear photonic crystals may prove to be a valuable ingredient in on-chip integrated quantum optics.

Cavity phase matching has been recently demonstrated as a phase-matching method for efficient nonlinear frequency conversion in a microcavity. Here we extend it to the Type I configuration using a sub-coherent-length optical parametric oscillator consisting of an MgO-doped lithium niobate crystal sheet. It generates a tunable single-longitudinal-mode twin beam, which covers the cesium D2 line of 852.1 nm and the extended band of optical communication. This microcavity is capable of peak output power of 58 kW with a maximum conversion efficiency of 18.5%. Broad applications in the areas of light-atom interaction, spectroscopy, optical telecommunication, and quantum optics can be expected., (© 2011 Optical Society of America)

A new scheme is presented to directly produce fundamental, second-, and third-harmonic three-color continuous-variable (CV) entangled beams by cascaded quasi-phase-matched third-harmonic generation (THG) in an optical cavity. THG can be achieved with high efficiency through a coupled sum-frequency process between the second-harmonic and the fundamental fields. It is demonstrated that the three beams (fundamental, second-, and third-harmonic fields) are entangled with each other according to the CV entanglement criterion. In this scheme, only one crystal and one pump field can generate three-color CV entangled beams separated by an octave in frequency through quasi-phase-matched cascaded nonlinear process, which may be very useful for the applications in quantum communication and computation networks.

Background: The pathophysiology of post-operative cognitive dysfunction remains unclear and there is no widely accepted animal model that can simulate its occurrence. The purpose of this study was to explore the effects of surgical stress on long-term post-operative memory function in mice of different ages., Methods: Healthy C57Bl/6J male mice, of either 4- or 16-month-old, were each randomly divided into three subgroups. (1) CONTROL GROUP: neither anesthesia nor surgery was performed; (2) Anesthesia group: general anesthesia was administrated, surgery was not performed; (3) Surgery group: two-thirds partial hepatectomy was completed in about 15 min under general anesthesia. Morris water maze test was performed after 30 days., Results: In mice of both month-ages, the escape latencies as well as the swimming distances decreased significantly across training days (P<0.001). In 4-month-old mice, there were no significant differences among three subgroups. In 16-month-old mice, the escape latency was significantly less in the surgery group than in the control group (P=0.001), and the swimming distance was significantly shorter in the surgery group than in the control and the anesthesia groups (P=0.001 and 0.047, respectively). In the spatial probe test, time spent in the target quadrant was significantly longer in the surgery group than in the combined control and anesthesia group (P=0.037)., Conclusions: Partial hepatectomy did not produce significant long-term effects on memory function in 4-month-old mice. However, it significantly improved long-term memory function in 16-month-old mice., (© 2011 The Authors. Acta Anaesthesiologica Scandinavica © 2011 The Acta Anaesthesiologica Scandinavica Foundation.)

In this Letter, we demonstrate a nonlinear-mirror (NLM) mode-locked diode-pumped solid-state Nd:YVO4 laser operating at 1342 nm, in which the NLM comprises a periodically poled LiNbO3 crystal and a dichroic mirror. The self-starting threshold for cw mode locking is 1.5 W, which is significantly lower than that of saturable absorber mode locking. An average power of 1.52 W at 1342 nm is obtained under diode pump power of 10 W at 808 nm, with the slope efficiency being up to 16.8%. The pulse width and the repetition rate of the mode-locked laser output are about 9.5 ps and 101 MHz, respectively.

We found that very strong negative optical pressure can be induced in plasmonic cavities by LC resonance. This interesting effect could be described qualitatively by a Lagrangian model which shows that the negative optical pressure is driven by the internal inductance and the kinetic energy of the conduction electrons. If the metal is replaced by perfect conductors, the optical pressure becomes much smaller and positive., (© 2011 American Physical Society)